Title:
USE OF MIR-29 FOR CELL PROTECTION
Document Type and Number:
WIPO Patent Application WO/2012/012676
Kind Code:
A3
Abstract:
The present invention relates to the regulation of apoptosis and expression of the BH3-only family of genes by miR-29. The invention further relates to the use of miR-29 to protect cells from apoptosis and to treat disorders associated with apoptosis.
Inventors:
DESHMUKH MOHANISH (US)
KOLE ADAM (US)
SWAHARI VIJAY (US)
HAMMOND SCOTT (US)
KOLE ADAM (US)
SWAHARI VIJAY (US)
HAMMOND SCOTT (US)
Application Number:
PCT/US2011/044922
Publication Date:
June 14, 2012
Filing Date:
July 22, 2011
Export Citation:
Assignee:
UNIV NORTH CAROLINA (US)
DESHMUKH MOHANISH (US)
KOLE ADAM (US)
SWAHARI VIJAY (US)
HAMMOND SCOTT (US)
DESHMUKH MOHANISH (US)
KOLE ADAM (US)
SWAHARI VIJAY (US)
HAMMOND SCOTT (US)
International Classes:
C12N15/113; A61K31/7105; A61K48/00; A61P25/28
Domestic Patent References:
| WO2008097277A2 | 2008-08-14 |
Foreign References:
| EP2371370A1 | 2011-10-05 |
Other References:
SIAMAK JABBARZADEH TABRIZI ET AL.: "T Cell Leukemia/Lymphoma 1 and Galectin-1 Regulate Survival/Cell Death Pathways in Human Naive and IgM+ Memory B Cells through Altering Balances in Bcl-2 Family Proteins", THE JOURNAL OF IMMUNOLOGY, vol. 182, 2009, pages 1490 - 1499
ADAM J. KOLE ET AL.: "miR-29b is activated during neuronal maturation and targets BH3-only genes to restrict apoptosis", GENES & DEVELOPMENT, vol. 25, 15 January 2011 (2011-01-15), pages 125 - 130
GUODONG SHI ET AL.: "Upregulated miR-29b promotes neuronal cell death by inhibiting Bcl2L2 after ischemic brain injury", EXP BRAIN RES, vol. 216, 18 November 2011 (2011-11-18), pages 225 - 230, XP035002276, DOI: doi:10.1007/s00221-011-2925-3
ADAM J. KOLE ET AL.: "miR-29b is activated during neuronal maturation and targets BH3-only genes to restrict apoptosis", GENES & DEVELOPMENT, vol. 25, 15 January 2011 (2011-01-15), pages 125 - 130
GUODONG SHI ET AL.: "Upregulated miR-29b promotes neuronal cell death by inhibiting Bcl2L2 after ischemic brain injury", EXP BRAIN RES, vol. 216, 18 November 2011 (2011-11-18), pages 225 - 230, XP035002276, DOI: doi:10.1007/s00221-011-2925-3
Attorney, Agent or Firm:
MYERS BIGEL SIBLEY & SAJOVEC, P.A. (Raleigh, North Carolina, US)
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