Title:
Use of mutated macrolide binding protein for the prevention of GVHD
Document Type and Number:
WIPO Patent Application WO1998008956
Kind Code:
A3
Abstract:
This invention is directed to a modified cyclosporin A and to a modified, genetically engineered version of its receptor, cyclophilin. This invention is further directed to a method for treating host versus graft disease following blood marrow transplantation by transfecting stem cells so that after introduction into a patient the stem cells will express the modified cyclophilin, and, as necessary, administer the modified cyclosporin A to the patient.
Inventors:
SCHREIBER STUART L (US)
BELSHAW PETER J (US)
CRABTREE GERALD (US)
BELSHAW PETER J (US)
CRABTREE GERALD (US)
Application Number:
PCT/US1997/015153
Publication Date:
June 18, 1998
Filing Date:
August 27, 1997
Export Citation:
Assignee:
HARVARD COLLEGE (US)
LELAND S STANFORD JUNIOR UNIVE (US)
SCHREIBER STUART L (US)
BELSHAW PETER J (US)
CRABTREE GERALD (US)
LELAND S STANFORD JUNIOR UNIVE (US)
SCHREIBER STUART L (US)
BELSHAW PETER J (US)
CRABTREE GERALD (US)
International Classes:
C12N15/09; A01K67/027; A61K31/35; A61K38/00; A61K48/00; A61P7/00; A61P37/00; C07K7/64; C07K14/47; C07K14/715; C12N5/10; C12N9/16; C12N9/90; C12N15/54; (IPC1-7): C12N15/54; A01K67/027; A61K48/00; C07K7/64; C07K14/715; C12N5/10; C12N9/12; C12N9/16; C12N9/90; C12N15/12
Domestic Patent References:
| WO1996006097A1 | 1996-02-29 | |||
| WO1996012806A1 | 1996-05-02 |
Other References:
FUTER O. ET AL.: "FK506 binding protein mutational analysis", J. BIOL. CHEM., vol. 270, no. 32, 11 August 1995 (1995-08-11), pages 18935 - 18940, XP002061406
DECENZO M.T.: "FK506-binding protein mutational analysis: defining the active site residue contributions to catalysis and the stability of ligand complexes", PROTEIN ENGINEERING, vol. 9, no. 2, 1996, pages 173 - 180, XP002061407
LUENGO J I ET AL: "STRUCTURE-ACTIVITY STUDIES OF RAPAMYCIN ANALOGS: EVIDENCE THAT THE C-7 METHOXY GROUP IS PART OF THE EFFECTOR DOMAIN AND POSITIONED AT THE FKBP12-FRAP INTERFACE", CHEMISTRY AND BIOLOGY, vol. 2, no. 7, 1995, pages 471 - 481, XP002045681
DECENZO M.T.: "FK506-binding protein mutational analysis: defining the active site residue contributions to catalysis and the stability of ligand complexes", PROTEIN ENGINEERING, vol. 9, no. 2, 1996, pages 173 - 180, XP002061407
LUENGO J I ET AL: "STRUCTURE-ACTIVITY STUDIES OF RAPAMYCIN ANALOGS: EVIDENCE THAT THE C-7 METHOXY GROUP IS PART OF THE EFFECTOR DOMAIN AND POSITIONED AT THE FKBP12-FRAP INTERFACE", CHEMISTRY AND BIOLOGY, vol. 2, no. 7, 1995, pages 471 - 481, XP002045681
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