Title:
USE OF MUTATIONS OF MEC-1 AND ITS RELATED GENES IN THE IDENTIFICATION OF COMPOUNDS FOR TREATMENT OF DISEASE
Document Type and Number:
WIPO Patent Application WO2003042411
Kind Code:
A3
Abstract:
The present invention relates to composition and methods of identifying one or more secondary drug targets and their use in the identification of drugs or drug candidates, particularly for the treatment of cancer or cell replication disorders. The yeast-based synthetic lethal screens are used to functionally identify and validate new gene targets to kill cells with defects in cell cycle pathways. These newly identified gene targets can be used to develop new therapeutics to treat cancer, benign cell growth, and yeast infections.
Application Number:
PCT/US2001/029631
Publication Date:
September 25, 2003
Filing Date:
October 03, 2000
Export Citation:
Assignee:
HUTCHINSON FRED CANCER RES (US)
International Classes:
A61K31/7052; A61K38/00; A61K45/00; A61K48/00; A61P1/04; A61P9/10; A61P13/08; A61P13/12; A61P17/02; A61P17/06; A61P17/12; A61P19/08; A61P25/14; A61P25/16; A61P25/28; A61P31/00; A61P35/00; A61P35/02; C12N1/15; C12N1/19; C12N5/10; C12N9/12; C12N15/09; C12Q1/02; C12Q1/68; C12Q1/6897; G01N33/15; G01N33/50; C12Q1/6883; C12Q1/6886; (IPC1-7): C12Q1/68; C12N5/10
Domestic Patent References:
| WO1999024603A1 | 1999-05-20 |
Other References:
HARTWELL L H ET AL: "INTEGRATING GENETIC APPROACHES INTO THE DISCOVERY OF ANTICANCER DRUGS", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, US, vol. 278, 7 November 1997 (1997-11-07), pages 1064 - 1068, XP002916842, ISSN: 0036-8075
POUILLART PHILIPPE R: "Role of butyric acid and its derivatives in the treatment of colorectal cancer and hemoglobinopathies.", LIFE SCIENCES, vol. 63, no. 20, 9 October 1998 (1998-10-09), pages 1739 - 1760, XP002246232, ISSN: 0024-3205
POUILLART PHILIPPE R: "Role of butyric acid and its derivatives in the treatment of colorectal cancer and hemoglobinopathies.", LIFE SCIENCES, vol. 63, no. 20, 9 October 1998 (1998-10-09), pages 1739 - 1760, XP002246232, ISSN: 0024-3205
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