Title:
USE OF A NEUROPEPTIDE IN TREATING BONE-INJURY DISEASE
Document Type and Number:
WIPO Patent Application WO/2023/134090
Kind Code:
A1
Abstract:
The present invention discloses a method for enhancing angiogenesis and osteogenesis using a neuropeptide so as to treat bone-injury disease. The present invention also provides a recombinant protein comprising a neuropeptide and a protein as self-assembling coatings and the use of recombinant protein for treating bone-injury disease.
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Inventors:
ZHONG CHAO (CN)
WANG YANYI (CN)
WANG YANYI (CN)
Application Number:
PCT/CN2022/091362
Publication Date:
July 20, 2023
Filing Date:
May 07, 2022
Export Citation:
Assignee:
SHENZHEN INSTITUTE OF ADVANCED TECH (CN)
International Classes:
A61K38/03; A61K38/16; A61P7/00; A61P9/00; A61P19/00
Foreign References:
| CA2223049A1 | 1996-12-19 | |||
| CN112972766A | 2021-06-18 |
Other References:
GAO Y， ET AL.: "Effect of neuropeptides on periodontium and oral bone repair", CHINESE JOURNAL OF TISSUE ENGINEERING RESEARCH, vol. 18, no. 11, 12 March 2014 (2014-03-12), XP009547731
XIE W， ET AL.: "The role of neuropeptide Y in the repair mechanism of bone microdamage.", CHIN J OSTEOPOROS, vol. 24, no. 3, 31 March 2018 (2018-03-31), XP009547732
SUN T， ET AL: "On the Therapeutic Effect of NPFF on Mouse Models with Rheumatoid Arthritis", RHEUMATISM AND ARTHRITIS, vol. 5, no. 7, 31 July 2016 (2016-07-31), XP009547733
GHERSI G， ET AL: "Critical role of dipeptidyl peptidase IV in neuropeptide Y-mediated endothelial cell migration in response to wounding", PEPTIDES, vol. 22, no. 3, 31 March 2001 (2001-03-31), XP002269330, DOI: 10.1016/S0196-9781(01)00340-0
XIE W， ET AL.: "The role of neuropeptide Y in the repair mechanism of bone microdamage.", CHIN J OSTEOPOROS, vol. 24, no. 3, 31 March 2018 (2018-03-31), XP009547732
SUN T， ET AL: "On the Therapeutic Effect of NPFF on Mouse Models with Rheumatoid Arthritis", RHEUMATISM AND ARTHRITIS, vol. 5, no. 7, 31 July 2016 (2016-07-31), XP009547733
GHERSI G， ET AL: "Critical role of dipeptidyl peptidase IV in neuropeptide Y-mediated endothelial cell migration in response to wounding", PEPTIDES, vol. 22, no. 3, 31 March 2001 (2001-03-31), XP002269330, DOI: 10.1016/S0196-9781(01)00340-0
Attorney, Agent or Firm:
LIFANG & PARTNERS (CN)
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