Title:
USE OF NICLOSAMIDE ETHANOLAMINE SALT IN PREPARING MEDICINE FOR TYPE 2 DIABETES
Document Type and Number:
WIPO Patent Application WO/2018/053954
Kind Code:
A1
Abstract:
Provided is a use of niclosamide ethanolamine salt in preparing medicine for preventing and treating type 2 diabetes. The niclosamide ethanolamine salt can reduce urinary albumin excretion rate of a type 2 diabetic db/db mice, improve pathological injury of glomeruli and renal tubular, and also has a protective effect on the liver.
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Inventors:
SUN HUILI (CN)
DU HENG (CN)
HAN PENGXUN (CN)
SHAO MUMIN (CN)
GUO LAN (CN)
DU HENG (CN)
HAN PENGXUN (CN)
SHAO MUMIN (CN)
GUO LAN (CN)
Application Number:
PCT/CN2016/110319
Publication Date:
March 29, 2018
Filing Date:
December 16, 2016
Export Citation:
Assignee:
SHENZHEN TRADITIONAL CHINESE MEDICINE HOSPITAL (CN)
International Classes:
A61K31/167; A61P3/10
Foreign References:
| CN106727472A | 2017-05-31 | |||
| CN103415287A | 2013-11-27 | |||
| CN1658850A | 2005-08-24 | |||
| CN105362280A | 2016-03-02 | |||
| CN101522207A | 2009-09-02 |
Other References:
TAO ET AL.: "Niclosamide ethanolamine-induced mild mitochondrial uncoupling improves diabetic symptoms in mice", NATURE MEDICINE, vol. 20, no. 11, 30 November 2014 (2014-11-30), pages 1263 - 1269, XP055249795
TURNER ET AL.: "Repurposing Drugs to Target the Diabetes Epidemic", TRENDS IN PHRAMACOLOGICAL SCIENCES, vol. 37, no. 5, 31 May 2016 (2016-05-31), pages 379 - 389, XP029519048
TURNER ET AL.: "Repurposing Drugs to Target the Diabetes Epidemic", TRENDS IN PHRAMACOLOGICAL SCIENCES, vol. 37, no. 5, 31 May 2016 (2016-05-31), pages 379 - 389, XP029519048
Attorney, Agent or Firm:
SHENZHEN STANDARD PATENT & TRADEMARK AGENT LTD. (CN)
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