Title:
USE OF NIR-II PHOTOTHERMAL MATERIAL IN PREPARATION OF DRUG FOR REVERSING MULTIDRUG RESISTANCE OF CANCER CELLS
Document Type and Number:
WIPO Patent Application WO/2023/169546
Kind Code:
A1
Abstract:
The use of an NIR-II photothermal material in preparation of a drug for reversing multidrug resistance of cancer cells. The NIR-II photothermal material is a small organic molecule fluorophore and has near-infrared-II fluorescence emission and a photothermal effect, the near-infrared-II fluorescence emission range being 900-1700 nm. Reversing multidrug resistance of cancer cells is realized on the basis of the photothermal effect of the NIR-II photothermal material, universality being good; and compared with a photodynamic effect, the photothermal effect has a wider effective treatment range. In addition, the NIR-II photothermal material has near-infrared-II fluorescence emission and an excellent photothermal effect, is suitable for photothermy, and can inhibit a protein expression pathway of cells such that expression of a drug-resistance related protein in drug-resistant cells is blocked and drug resistance cannot be generated, thus effectively accumulating a chemotherapeutic drug in cells so as to generate cytotoxicity, and realizing the reversal of drug resistance of drug-resistant cancer cells.
Inventors:
TANG BENZHONG (CN)
DU KAIHONG (CN)
QIN ANJUN (CN)
HU RONG (CN)
DU KAIHONG (CN)
QIN ANJUN (CN)
HU RONG (CN)
Application Number:
PCT/CN2023/080704
Publication Date:
September 14, 2023
Filing Date:
March 10, 2023
Export Citation:
Assignee:
UNIV SOUTH CHINA TECH (CN)
International Classes:
A61K41/00; A61K9/14; A61K47/24; A61K47/59; A61K47/69; A61P35/00; C07D513/04; C09K11/06
Foreign References:
| CN114668840A | 2022-06-28 | |||
| US20200338211A1 | 2020-10-29 | |||
| CN108853512A | 2018-11-23 |
Other References:
BOHRA HASSAN, TAN SI YU, SHAO JINJUN, YANG CANGJIE, EFREM AMSALU, ZHAO YANLI, WANG MINGFENG: "Narrow bandgap thienothiadiazole-based conjugated porous polymers: from facile direct arylation polymerization to tunable porosities and optoelectronic properties", POLYMER CHEMISTRY, ROYAL SOCIETY OF CHEMISTRY, CAMBRIDGE, vol. 7, no. 41, 1 January 2016 (2016-01-01), Cambridge , pages 6413 - 6421, XP093090085, ISSN: 1759-9954, DOI: 10.1039/C6PY01453D
LI YANG, GAO JIANFENG, WANG SHUPING, LI SHIJUN, HOU XIAOWEN, PAN YANNA, GAO JIALU, QIAO XUE, TIAN ZHIQUAN, CHEN DELIANG, DENG HAI,: "Organic NIR-II dyes with ultralong circulation persistence for image-guided delivery and therapy", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, vol. 342, 1 February 2022 (2022-02-01), AMSTERDAM, NL , pages 157 - 169, XP093090088, ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2022.01.005
LI YANG, GAO JIANFENG, WANG SHUPING, LI SHIJUN, HOU XIAOWEN, PAN YANNA, GAO JIALU, QIAO XUE, TIAN ZHIQUAN, CHEN DELIANG, DENG HAI,: "Organic NIR-II dyes with ultralong circulation persistence for image-guided delivery and therapy", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, vol. 342, 1 February 2022 (2022-02-01), AMSTERDAM, NL , pages 157 - 169, XP093090088, ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2022.01.005
Attorney, Agent or Firm:
HANGZHOU TIANQIN INTELLECTUAL PROPERTY AGENCY CO., LTD (CN)
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