Title:
USE OF NOCARDIA RUBRA CELL WALL SKELETON IN REGENERATIVE MEDICINE
Document Type and Number:
WIPO Patent Application WO/2021/147900
Kind Code:
A1
Abstract:
The present disclosure relates to a use of Nocardia rubra cell wall skeleton in regenerative medicine, and in particular, to a use of Nocardia rubra (especially the cell wall skeleton thereof) in the following aspects: promoting proliferation, growth, differentiation and migration of stem cells, and improving the survival rate of the stem cells, wherein the stem cells are selected from: adult stem cells, iPSC, and mesenchymal stem cells.
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Inventors:
GAI BO (CN)
DOU CHUNYAN (CN)
JIN PEISHENG (CN)
ZHANG YI (CN)
ZHANG GUOYING (CN)
DOU CHUNYAN (CN)
JIN PEISHENG (CN)
ZHANG YI (CN)
ZHANG GUOYING (CN)
Application Number:
PCT/CN2021/072874
Publication Date:
July 29, 2021
Filing Date:
January 20, 2021
Export Citation:
Assignee:
LIAONING GREATEST BIO PHARMACEUTICAL CO LTD (CN)
International Classes:
C12N5/0775; A61K35/74; C12N1/20; C12N5/074; C12N5/077; C12N5/10; C12R1/01
Foreign References:
| CN1443542A | 2003-09-24 | |||
| CN1094288A | 1994-11-02 | |||
| CN108795859A | 2018-11-13 | |||
| CN112040962A | 2020-12-04 | |||
| CN111683670A | 2020-09-18 | |||
| CN111359010A | 2020-07-03 | |||
| CN202010068070A | 2020-01-21 | |||
| CN101073583A | 2007-11-21 | |||
| CN1935262A | 2007-03-28 | |||
| CN101209267A | 2008-07-02 | |||
| CN108938674A | 2018-12-07 | |||
| CN108295095A | 2018-07-20 | |||
| CN1879661A | 2006-12-20 | |||
| CN101250490A | 2008-08-27 | |||
| CN101323865A | 2008-12-17 |
Other References:
LOMBARDO ELEUTERIO, DELAROSA OLGA, MANCHEÑO-CORVO PABLO, MENTA RAMÓN, RAMÍREZ CRISTINA, BÜSCHER DIRK: "Toll-like Receptor–Mediated Signaling in Human Adipose-Derived Stem Cells: Implications for Immunogenicity and Immunosuppressive Potential", TISSUE ENGINEERING PART A, MARY ANN LIEBERT, US, vol. 15, no. 7, 1 July 2009 (2009-07-01), US, pages 1579 - 1589, XP055830897, ISSN: 1937-3341, DOI: 10.1089/ten.tea.2008.0340
SU YANAN, BAI HAI,WANG CUN-BANG,MA XIAO-HUI,OU JIAN-FENG,ZHAO QIANG,HE XIAO-XIA: "Effects of Peptidoglycan on Proliferation and Cell Cycle of Human Bone Marrow-derived Mesenchymal Stem Cells", JOURNAL OF EXPERIMENTALHEMATOLOGY, vol. 18, no. 4, 1 January 2010 (2010-01-01), CN , pages 986 - 990, XP055830899, ISSN: 1009-2137
HWA CHO HYUN, BAE YONG CHAN, JUNG JIN SUP: "Role of Toll-Like Receptors on Human Adipose-Derived Stromal Cells", STEM CELLS, vol. 24, no. 12, 1 December 2006 (2006-12-01), pages 2744 - 2752, XP055830900, ISSN: 1066-5099, DOI: 10.1634/stemcells.2006-0189
OLGA DELAROSA, ELEUTERIO LOMBARDO: "Modulation of Adult Mesenchymal Stem Cells Activity by Toll-Like Receptors: Implications on Therapeutic Potential", MEDIATORS OF INFLAMMATION., RAPID COMMUNICATION OF OXFORD LTD., OXFORD., GB, vol. 2010, 1 January 2010 (2010-01-01), GB, pages 1 - 9, XP055343265, ISSN: 0962-9351, DOI: 10.1155/2010/865601
MOHSEN KHOSRAVI MAHARLOOEI; MANSOOREH BAGHERI; ZHABIZ SOLHJOU; BEHNAM MOEIN JAHROMI; MAJID AKRAMI; LILI ROHANI; AHMAD MONABATI; AL: "Adipose tissue derived mesenchymal stem cell (AD-MSC) promotes skin wound healing in diabetic rats", DIABETES RESEARCH AND CLINICAL PRACTICE, AMSTERDAM, NL, vol. 93, no. 2, 25 April 2011 (2011-04-25), NL, pages 228 - 234, XP028260761, ISSN: 0168-8227, DOI: 10.1016/j.diabres.2011.04.018
OHARA KANAME, YURI HIRANO, HISAO ISHIDA, TAKASHI FUJITSU, TAKAHURU ONO, JO MORI, AKIRA TENSHO: "A Possible Mechanism of Fever Induced by Nocardia Rubra Cell Wall Skeleton (N-CWS) in Experimental Animals", CHEMICAL & PHARMACEUTICAL BULLETIN, vol. 37, no. 10, 1 January 1989 (1989-01-01), pages 2790 - 2794, XP055830902
FIEDLER TOMAS, ACHIM SALAMON, STEFANIE ADAM, NICOLE HERZMANN, JAN TAUBENHEIM, KIRSTEN PETERS: "Impact of Bacteria and Bacterial Components on Osteogenic and Adipogenic Differentiation of Adipose-Derived Mesenchymal Stem Cells", EXPERIMENTAL CELL RESEARCH, vol. 319, 27 August 2013 (2013-08-27), pages 2883 - 2892, XP055830904, DOI: 10.1016/j.yexcr.2013.08.020
HONGLIANG ZHANG ET AL.: "Clinical effect of adipose stem cells by local injection for chronic wound of diabetes mellitus", INT. J. PATHOL. CLIN. MED., vol. 39, no. 9, 2019, pages 1940 - 1945
WEI ZHENG ET AL.: "Analysis of the effect of autologous adipose-derived stem cells combined with sterile biological wound film on the healing of chronic wounds", DIET HEALTH, vol. 6, no. 15, 2019, pages 49 - 50
NUSCHKE A: "Activity of mesenchymal stem cells in therapies for chronic skin wound healing", ORGANOGEN, vol. 10, 2014, pages 29 - 37
DAS R ET AL.: "The role of hypoxia in bone marrow derived mesenchymal stem cells: Considerations for regenerative medicine approaches. Tissue Eng", PART B REV, vol. 16, 2010, pages 159 - 168
S. IZUMI ET AL.: "Antitumor effect of Nocardia rubra cell wall skeleton on syngeneicaly transplanted P388 tumors", CANCER RES., vol. 51, no. 15, 1991, pages 4038 - 4044
J. ZHAO ET AL., EFFECT OF NOCARDIA RUBRA CELL WALL SKELETON (NR-CWS) ON ONCOGENICITY OF TC-1 CELLS AND ANTI-HUMAN PAPILLOMAVIRUS EFFECT OF NR-CWS IN LOWER GENITAL TRACT OF WOMEN, vol. 21, no. 4, 2007, pages 340 - 342
HUA ZOU ET AL.: "Analysis of diagnosis and treatment and prognosis factor for 438 cases of malignant pleural effusion with lung cancer", CHONGQING MED., vol. 44, no. 27, 2015, pages 3794 - 3797,3802
SHUNLI YU ET AL.: "The value of intravesical instillation of Nocardia rubra cell wall skeleton in preventing recurrent after transurethral resection for the treatment of non-muscle invasive bladder cancer", CHINESE J. UROL., vol. 40, no. 7, 2019, pages 521 - 525
YONGXIAN HUO: "Efficacy observation of topical application of Nocardia rubra cell wall skeleton preparation in the treatment of cervical human papillomavirus subclinical infection", MOD. DIAGN. TREAT., vol. 30, no. 16, 2019, pages 2865 - 2866
LI QI ET AL.: "Clinical effects of intrathoracic injection of Nocardia cell wall skeleton in the treatment of malignant pleural effusion", CHINESE J. PRACTICAL MED., vol. 46, no. 20, 2019, pages 104 - 106
RATHUR HM ET AL., THE DIABETIC FOOT. CLIN. DERMATOL., vol. 25, no. 1, 2007, pages 109 - 120
GUO WY ET AL.: "Acceleration of diabetic wood healing by low-dose radiation is associated with peripheral mobilization of bone marrow stem cells", RADIAT. RES., vol. 174, no. 4, 2010, pages 467 - 479
FIORINA P ET AL.: "The mobilization and effect of endogenous bone marrow progenitor cells diabetic wound healing", CELL TRANSPLANT., vol. 19, no. 11, 2010, pages 1369 - 1381
PING XIE ET AL.: "Detection and Typing of HPV in Cervical Intraepithelial Neoplasia", MOD. DIAGN. TREAT., vol. 27, no. 13, 2016, pages 2381 - 2382
KAISANG LIN ET AL.: "Adipose-derived stem cells seeded in Pluronic F-127 hydrogel promotes diabetic wound healing", J. SURGICAL RES., vol. 217, 2017, pages 63 - 74
GONG JH ET AL.: "Influence of AGEs environment on proliferation, apoptosis, and endothelial cell differentiation of human adipose stem cells", INT. J. LOW EXTREM WOUNDS., vol. 16, no. 2, 2017, pages 94 - 103
KATO Y ET AL.: "Creation and transplantation of an adipose-derived stem cell (ASC) sheet in a diabetic wound-healing model", JOVE-J VIS EXP., vol. 12, no. 6, 2017, pages 1 - 10
REHMAN J ET AL.: "Secretion of angiogenic and anti-apoptotic factors by human adipose stromal cells", CIRCULATION, vol. 109, 2004, pages 1292 - 8
EBRAHIMIAN TG ET AL.: "Cell therapy based on adipose tissue-derived stromal cells promotes physiological and pathological wound healing. Arterioscler", THROMB. VASE. BIOL., vol. 29, no. 4, 2009, pages 503 - 510
KIM WS ET AL.: "Wound healing effect of adipose-derived stem cells: a critical role of secretory factors on human dermal fibroblasts", J. DERMATOL. SCI, vol. 48, 2007, pages 15 - 24, XP022209301, DOI: 10.1016/j.jdermsci.2007.05.018
UNNIKRISHNAN S ET AL.: "Constitution of fibrin-based niche for in vitro differentiation of adipose-derived mesenchymal stem cells to keratinocytes", BIORES OPEN ACCESS., vol. 3, no. 6, 2014, pages 339 - 347
LI Q ET AL.: "miR-5591-5p regulates the effect of ADSCs in repairing diabetic wound via targeting AGEs/AGER/JNK signaling axis", CELL DEATH DIS, vol. 9, 2018, pages 566
LI Q ET AL.: "Stromal cell-derived factor-1 promotes human adipose tissue-derived stem cell survival and chronic wound healing", EXP THER MED., vol. 12, 2016, pages 45 - 50
See also references of EP 4056682A4
SU YANAN, BAI HAI,WANG CUN-BANG,MA XIAO-HUI,OU JIAN-FENG,ZHAO QIANG,HE XIAO-XIA: "Effects of Peptidoglycan on Proliferation and Cell Cycle of Human Bone Marrow-derived Mesenchymal Stem Cells", JOURNAL OF EXPERIMENTALHEMATOLOGY, vol. 18, no. 4, 1 January 2010 (2010-01-01), CN , pages 986 - 990, XP055830899, ISSN: 1009-2137
HWA CHO HYUN, BAE YONG CHAN, JUNG JIN SUP: "Role of Toll-Like Receptors on Human Adipose-Derived Stromal Cells", STEM CELLS, vol. 24, no. 12, 1 December 2006 (2006-12-01), pages 2744 - 2752, XP055830900, ISSN: 1066-5099, DOI: 10.1634/stemcells.2006-0189
OLGA DELAROSA, ELEUTERIO LOMBARDO: "Modulation of Adult Mesenchymal Stem Cells Activity by Toll-Like Receptors: Implications on Therapeutic Potential", MEDIATORS OF INFLAMMATION., RAPID COMMUNICATION OF OXFORD LTD., OXFORD., GB, vol. 2010, 1 January 2010 (2010-01-01), GB, pages 1 - 9, XP055343265, ISSN: 0962-9351, DOI: 10.1155/2010/865601
MOHSEN KHOSRAVI MAHARLOOEI; MANSOOREH BAGHERI; ZHABIZ SOLHJOU; BEHNAM MOEIN JAHROMI; MAJID AKRAMI; LILI ROHANI; AHMAD MONABATI; AL: "Adipose tissue derived mesenchymal stem cell (AD-MSC) promotes skin wound healing in diabetic rats", DIABETES RESEARCH AND CLINICAL PRACTICE, AMSTERDAM, NL, vol. 93, no. 2, 25 April 2011 (2011-04-25), NL, pages 228 - 234, XP028260761, ISSN: 0168-8227, DOI: 10.1016/j.diabres.2011.04.018
OHARA KANAME, YURI HIRANO, HISAO ISHIDA, TAKASHI FUJITSU, TAKAHURU ONO, JO MORI, AKIRA TENSHO: "A Possible Mechanism of Fever Induced by Nocardia Rubra Cell Wall Skeleton (N-CWS) in Experimental Animals", CHEMICAL & PHARMACEUTICAL BULLETIN, vol. 37, no. 10, 1 January 1989 (1989-01-01), pages 2790 - 2794, XP055830902
FIEDLER TOMAS, ACHIM SALAMON, STEFANIE ADAM, NICOLE HERZMANN, JAN TAUBENHEIM, KIRSTEN PETERS: "Impact of Bacteria and Bacterial Components on Osteogenic and Adipogenic Differentiation of Adipose-Derived Mesenchymal Stem Cells", EXPERIMENTAL CELL RESEARCH, vol. 319, 27 August 2013 (2013-08-27), pages 2883 - 2892, XP055830904, DOI: 10.1016/j.yexcr.2013.08.020
HONGLIANG ZHANG ET AL.: "Clinical effect of adipose stem cells by local injection for chronic wound of diabetes mellitus", INT. J. PATHOL. CLIN. MED., vol. 39, no. 9, 2019, pages 1940 - 1945
WEI ZHENG ET AL.: "Analysis of the effect of autologous adipose-derived stem cells combined with sterile biological wound film on the healing of chronic wounds", DIET HEALTH, vol. 6, no. 15, 2019, pages 49 - 50
NUSCHKE A: "Activity of mesenchymal stem cells in therapies for chronic skin wound healing", ORGANOGEN, vol. 10, 2014, pages 29 - 37
DAS R ET AL.: "The role of hypoxia in bone marrow derived mesenchymal stem cells: Considerations for regenerative medicine approaches. Tissue Eng", PART B REV, vol. 16, 2010, pages 159 - 168
S. IZUMI ET AL.: "Antitumor effect of Nocardia rubra cell wall skeleton on syngeneicaly transplanted P388 tumors", CANCER RES., vol. 51, no. 15, 1991, pages 4038 - 4044
J. ZHAO ET AL., EFFECT OF NOCARDIA RUBRA CELL WALL SKELETON (NR-CWS) ON ONCOGENICITY OF TC-1 CELLS AND ANTI-HUMAN PAPILLOMAVIRUS EFFECT OF NR-CWS IN LOWER GENITAL TRACT OF WOMEN, vol. 21, no. 4, 2007, pages 340 - 342
HUA ZOU ET AL.: "Analysis of diagnosis and treatment and prognosis factor for 438 cases of malignant pleural effusion with lung cancer", CHONGQING MED., vol. 44, no. 27, 2015, pages 3794 - 3797,3802
SHUNLI YU ET AL.: "The value of intravesical instillation of Nocardia rubra cell wall skeleton in preventing recurrent after transurethral resection for the treatment of non-muscle invasive bladder cancer", CHINESE J. UROL., vol. 40, no. 7, 2019, pages 521 - 525
YONGXIAN HUO: "Efficacy observation of topical application of Nocardia rubra cell wall skeleton preparation in the treatment of cervical human papillomavirus subclinical infection", MOD. DIAGN. TREAT., vol. 30, no. 16, 2019, pages 2865 - 2866
LI QI ET AL.: "Clinical effects of intrathoracic injection of Nocardia cell wall skeleton in the treatment of malignant pleural effusion", CHINESE J. PRACTICAL MED., vol. 46, no. 20, 2019, pages 104 - 106
RATHUR HM ET AL., THE DIABETIC FOOT. CLIN. DERMATOL., vol. 25, no. 1, 2007, pages 109 - 120
GUO WY ET AL.: "Acceleration of diabetic wood healing by low-dose radiation is associated with peripheral mobilization of bone marrow stem cells", RADIAT. RES., vol. 174, no. 4, 2010, pages 467 - 479
FIORINA P ET AL.: "The mobilization and effect of endogenous bone marrow progenitor cells diabetic wound healing", CELL TRANSPLANT., vol. 19, no. 11, 2010, pages 1369 - 1381
PING XIE ET AL.: "Detection and Typing of HPV in Cervical Intraepithelial Neoplasia", MOD. DIAGN. TREAT., vol. 27, no. 13, 2016, pages 2381 - 2382
KAISANG LIN ET AL.: "Adipose-derived stem cells seeded in Pluronic F-127 hydrogel promotes diabetic wound healing", J. SURGICAL RES., vol. 217, 2017, pages 63 - 74
GONG JH ET AL.: "Influence of AGEs environment on proliferation, apoptosis, and endothelial cell differentiation of human adipose stem cells", INT. J. LOW EXTREM WOUNDS., vol. 16, no. 2, 2017, pages 94 - 103
KATO Y ET AL.: "Creation and transplantation of an adipose-derived stem cell (ASC) sheet in a diabetic wound-healing model", JOVE-J VIS EXP., vol. 12, no. 6, 2017, pages 1 - 10
REHMAN J ET AL.: "Secretion of angiogenic and anti-apoptotic factors by human adipose stromal cells", CIRCULATION, vol. 109, 2004, pages 1292 - 8
EBRAHIMIAN TG ET AL.: "Cell therapy based on adipose tissue-derived stromal cells promotes physiological and pathological wound healing. Arterioscler", THROMB. VASE. BIOL., vol. 29, no. 4, 2009, pages 503 - 510
KIM WS ET AL.: "Wound healing effect of adipose-derived stem cells: a critical role of secretory factors on human dermal fibroblasts", J. DERMATOL. SCI, vol. 48, 2007, pages 15 - 24, XP022209301, DOI: 10.1016/j.jdermsci.2007.05.018
UNNIKRISHNAN S ET AL.: "Constitution of fibrin-based niche for in vitro differentiation of adipose-derived mesenchymal stem cells to keratinocytes", BIORES OPEN ACCESS., vol. 3, no. 6, 2014, pages 339 - 347
LI Q ET AL.: "miR-5591-5p regulates the effect of ADSCs in repairing diabetic wound via targeting AGEs/AGER/JNK signaling axis", CELL DEATH DIS, vol. 9, 2018, pages 566
LI Q ET AL.: "Stromal cell-derived factor-1 promotes human adipose tissue-derived stem cell survival and chronic wound healing", EXP THER MED., vol. 12, 2016, pages 45 - 50
See also references of EP 4056682A4
Attorney, Agent or Firm:
GE CHENG & CO., LTD (CN)
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