Title:
USE OF NOVEL LOCUS OF CALLIPYGE GENE IN SHEEP BREEDING
Document Type and Number:
WIPO Patent Application WO/2024/065376
Kind Code:
A1
Abstract:
Disclosed in the present invention is the use of a differentially methylated region of callipyge gene in meat trait breeding. Disclosed in the present invention is a differentially methylated region from an imprinted region Dlk1-Mirg of sheep callipyge gene, the nucleotide sequence of the differentially methylated region being shown as SEQ ID NO: 1. The differentially methylated region and an associated gene Gtl2 thereof can be used for early-stage breeding of meat traits of sheep. Further disclosed in the present invention is that a differentially methylated region shown as SEQ ID NO: 2 of a Dlk1-Mirg region of mice and an associated gene Meg3 thereof can be used for regulating and controlling the body weight of mice and constructing a weight loss mouse model.
Inventors:
DENG XUEMEI (CN)
WANG JIANKUI (CN)
WANG JIANKUI (CN)
Application Number:
PCT/CN2022/122505
Publication Date:
April 04, 2024
Filing Date:
September 29, 2022
Export Citation:
Assignee:
UNIV CHINA AGRICULTURAL (CN)
International Classes:
C12Q1/6888; C12N15/11
Foreign References:
| CN107151693A | 2017-09-12 | |||
| CN106755422A | 2017-05-31 |
Other References:
GAO XIAOTONG: "Advances on the mechanism of long noncoding RNA-MEG3 affecting muscle development", HEILONGJIANG ANIMAL SCIENCE AND VETERINARY MEDICINE, vol. 159, no. 03, 10 February 2021 (2021-02-10), pages 50 - 53, XP093152541, DOI: ：10.13881/j．cnki．hljxmsy．2020.07.0376
KARIN SCHUSTER-GOSSLER ET AL.: "The mouse Gtl2 gene is differentially expressed during embryonic development, encodes multiple alternatively spliced transcripts, and may act as an RNA", DEV DYN, vol. 212, no. 2, 7 December 1998 (1998-12-07), XP071967360, ISSN: 1058-8388, DOI: 10.1002/(SICI)1097-0177(199806)212:2<214::AID-AJA6>3.0.CO;2-K
F. Y. CHEN; H. NIU; J. Q. WANG; C. Z. LEI; X. Y. LAN; C. L. ZHANG; M. J. LI; L. S. HUA; J. WANG; H. CHEN: "Polymorphism ofandgene and their association with phenotypic traits in Chinese cattle", MOLECULAR BIOLOGY REPORTS ; AN INTERNATIONAL JOURNAL ON MOLECULAR AND CELLULAR BIOLOGY, KLUWER ACADEMIC PUBLISHERS, DO, vol. 38, no. 1, 30 March 2010 (2010-03-30), Do , pages 243 - 248, XP019866483, ISSN: 1573-4978, DOI: 10.1007/s11033-010-0101-7
TAKESHI SAITO: "Deletion of conserved sequences in IG-DMR at Dlk1-Gtl2 locus suggests their involvement in expression of paternally expressed genes in mice", JOURNAL OF REPRODUCTION AND DEVELOPMENT, FUCHU, JP, vol. 63, no. 1, 1 December 2016 (2016-12-01), JP , pages 101 - 109, XP093152535, ISSN: 0916-8818, DOI: 10.1262/jrd.2016-135
KARIN SCHUSTER-GOSSLER ET AL.: "The mouse Gtl2 gene is differentially expressed during embryonic development, encodes multiple alternatively spliced transcripts, and may act as an RNA", DEV DYN, vol. 212, no. 2, 7 December 1998 (1998-12-07), XP071967360, ISSN: 1058-8388, DOI: 10.1002/(SICI)1097-0177(199806)212:2<214::AID-AJA6>3.0.CO;2-K
F. Y. CHEN; H. NIU; J. Q. WANG; C. Z. LEI; X. Y. LAN; C. L. ZHANG; M. J. LI; L. S. HUA; J. WANG; H. CHEN: "Polymorphism ofandgene and their association with phenotypic traits in Chinese cattle", MOLECULAR BIOLOGY REPORTS ; AN INTERNATIONAL JOURNAL ON MOLECULAR AND CELLULAR BIOLOGY, KLUWER ACADEMIC PUBLISHERS, DO, vol. 38, no. 1, 30 March 2010 (2010-03-30), Do , pages 243 - 248, XP019866483, ISSN: 1573-4978, DOI: 10.1007/s11033-010-0101-7
TAKESHI SAITO: "Deletion of conserved sequences in IG-DMR at Dlk1-Gtl2 locus suggests their involvement in expression of paternally expressed genes in mice", JOURNAL OF REPRODUCTION AND DEVELOPMENT, FUCHU, JP, vol. 63, no. 1, 1 December 2016 (2016-12-01), JP , pages 101 - 109, XP093152535, ISSN: 0916-8818, DOI: 10.1262/jrd.2016-135
Attorney, Agent or Firm:
JEEKAI&PARTNERS (CN)
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