Title:
USE OF NSAIDS FOR PREVENTION AND TREATMENT OF CELLULAR ABNORMALITIES OF THE LUNG OR BRONCHIAL PATHWAY
Document Type and Number:
WIPO Patent Application WO2002085342
Kind Code:
A3
Abstract:
The invention is directed to uses of non-steroidal anti-inflammatory drugs (NSAIDs) for the treatment and prevention of cellular abnormalities of the lung or bronchial pathway.
Inventors:
PRIOR CHRISTOPHER P
EISEN DRORE (US)
HERLANDS LOUIS (US)
EISEN DRORE (US)
HERLANDS LOUIS (US)
Application Number:
PCT/US2002/012321
Publication Date:
January 15, 2004
Filing Date:
April 18, 2002
Export Citation:
Assignee:
ORALTECH PHARMACEUTICALS INC (US)
EISEN DRORE (US)
HERLANDS LOUIS (US)
EISEN DRORE (US)
HERLANDS LOUIS (US)
International Classes:
A61K31/00; A61K31/407; A61K45/06; A61P35/00; (IPC1-7): A61K31/00; A61P35/00; A61K31/407; A61K45/06
Domestic Patent References:
| WO1998009603A2 | 1998-03-12 | |||
| WO1999049859A1 | 1999-10-07 | |||
| WO1998040066A1 | 1998-09-17 |
Foreign References:
| US6008260A | 1999-12-28 |
Other References:
JALBERT AND CASTONGUAY: "Effects of NSAIDs on NNK-induced pulmonary and gastric tumorigenesis in A/J mice", CANCER LETTERS, vol. 66, 1992, pages 21 - 28, XP008018558
CALDWELL J ET AL: "THE METABOLIC CHIRAL INVERSION AND DISPOSITIONAL ENANTOSELECTIVITY OF THE 2-ARYLPROPIONIC ACIDS AND THEIR BIOLOGICAL CONSEQUENCES", BIOCHEMICAL PHARMACOLOGY, PERGAMON, OXFORD, GB, vol. 37, no. 1, 1988, pages 105 - 114, XP000874167, ISSN: 0006-2952
WARNER ET AL: "Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis", PROC. NATL. ACAD. SCI. USA, vol. 96, June 1999 (1999-06-01), pages 7563 - 7568, XP002246259
CALDWELL J ET AL: "THE METABOLIC CHIRAL INVERSION AND DISPOSITIONAL ENANTOSELECTIVITY OF THE 2-ARYLPROPIONIC ACIDS AND THEIR BIOLOGICAL CONSEQUENCES", BIOCHEMICAL PHARMACOLOGY, PERGAMON, OXFORD, GB, vol. 37, no. 1, 1988, pages 105 - 114, XP000874167, ISSN: 0006-2952
WARNER ET AL: "Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis", PROC. NATL. ACAD. SCI. USA, vol. 96, June 1999 (1999-06-01), pages 7563 - 7568, XP002246259
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