Title:
USE OF NUCLEAR MATERIAL TO THERAPEUTICALLY REPROGRAM DIFFERENTIATED CELLS
Document Type and Number:
WIPO Patent Application WO2006084229
Kind Code:
A3
Abstract:
Methods are provided for therapeutically reprogramming differentiated cells with nuclear extracts from pluripotent stem cells to generate a pluripotent epigenetic state in the differentiated cells. Additionally, therapeutically programmed cells for therapeutic use in patients are provided. Therapeutically programmed cells are stem cells which have been matured such that they represent either a more differentiated state or a less differentiated state after contact with stimulatory factors.
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Inventors:
SAYRE CHAUNCEY B (US)
SILVA FRANCISCO J (US)
SILVA FRANCISCO J (US)
Application Number:
PCT/US2006/004077
Publication Date:
October 05, 2006
Filing Date:
February 02, 2006
Export Citation:
Assignee:
PRIMEGEN BIOTECH LLC (US)
SAYRE CHAUNCEY B (US)
SILVA FRANCISCO J (US)
SAYRE CHAUNCEY B (US)
SILVA FRANCISCO J (US)
International Classes:
C12N5/00; C12N5/074
Domestic Patent References:
| WO2002014469A2 | 2002-02-21 |
Foreign References:
| US20020136709A1 | 2002-09-26 | |||
| EP1437404A1 | 2004-07-14 |
Other References:
DONOVAN P J ET AL: "Turning germ cells into stem cells", CURRENT OPINION IN GENETICS & DEVELOPMENT, CURRENT BIOLOGY LTD, XX, vol. 13, no. 5, October 2003 (2003-10-01), pages 463 - 471, XP002355791, ISSN: 0959-437X
HANSIS C ET AL: "Nuclear Reprogramming of Human Somatic Cells by Xenopus Egg Extract Requires BRG1", CURRENT BIOLOGY, CURRENT SCIENCE,, GB, vol. 14, no. 16, 24 August 2004 (2004-08-24), pages 1475 - 1480, XP004548528, ISSN: 0960-9822
COLLAS PHILIPPE ET AL: "Teaching cells new tricks.", TRENDS IN BIOTECHNOLOGY, vol. 21, no. 8, August 2003 (2003-08-01), pages 354 - 361, XP002388461, ISSN: 0167-7799
HANSIS C ET AL: "Nuclear Reprogramming of Human Somatic Cells by Xenopus Egg Extract Requires BRG1", CURRENT BIOLOGY, CURRENT SCIENCE,, GB, vol. 14, no. 16, 24 August 2004 (2004-08-24), pages 1475 - 1480, XP004548528, ISSN: 0960-9822
COLLAS PHILIPPE ET AL: "Teaching cells new tricks.", TRENDS IN BIOTECHNOLOGY, vol. 21, no. 8, August 2003 (2003-08-01), pages 354 - 361, XP002388461, ISSN: 0167-7799
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