Title:
USE OF NUCLEIC ACID LIBRARIES TO CREATE TOXICOLOGICAL PROFILES
Document Type and Number:
WIPO Patent Application WO2002068698
Kind Code:
A3
Abstract:
This invention features methods of generating toxicity profiles of compounds by screening expression libraries with the compounds. The profiles contain lists of proteins (or other biomolecules) to which the compounds bind and optionally information on the strength of binding.
Inventors:
DAHIYAT BASSIL (US)
LI MIN (US)
LI MIN (US)
Application Number:
PCT/US2002/008023
Publication Date:
January 29, 2004
Filing Date:
February 22, 2002
Export Citation:
Assignee:
XENCOR INC (US)
DAHIYAT BASSIL (US)
LI MIN (US)
DAHIYAT BASSIL (US)
LI MIN (US)
International Classes:
C12N15/10; (IPC1-7): C12Q1/68; G01N33/68; C12Q1/00
Domestic Patent References:
| WO2001014539A2 | 2001-03-01 | |||
| WO2002022826A2 | 2002-03-21 |
Other References:
BURCHIEL SCOTT W ET AL: "Analysis of genetic and epigenetic mechanisms of toxicity: Potential roles of toxicogenomics and proteomics in toxicology", TOXICOLOGICAL SCIENCES, vol. 59, no. 2, February 2001 (2001-02-01), pages 193 - 195, XP009020179, ISSN: 1096-6080
NUWAYSIR E F ET AL: "MICROARRAYS AND TOXICOLOGY: THE ADVENT OF TOXICOGENOMICS", MOLECULAR CARCINOGENESIS, ALAN LISS, NEW YORK, NY,, US, vol. 24, no. 3, March 1999 (1999-03-01), pages 153 - 159, XP001008421, ISSN: 0899-1987
RUEPP STEFAN U ET AL: "Genomics and proteomics analysis of acetaminophen toxicity in mouse liver", TOXICOLOGICAL SCIENCES, vol. 65, no. 1, January 2002 (2002-01-01), pages 135 - 150, XP009020274, ISSN: 1096-6080
NUWAYSIR E F ET AL: "MICROARRAYS AND TOXICOLOGY: THE ADVENT OF TOXICOGENOMICS", MOLECULAR CARCINOGENESIS, ALAN LISS, NEW YORK, NY,, US, vol. 24, no. 3, March 1999 (1999-03-01), pages 153 - 159, XP001008421, ISSN: 0899-1987
RUEPP STEFAN U ET AL: "Genomics and proteomics analysis of acetaminophen toxicity in mouse liver", TOXICOLOGICAL SCIENCES, vol. 65, no. 1, January 2002 (2002-01-01), pages 135 - 150, XP009020274, ISSN: 1096-6080
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