Title:
USE OF OPIOID FOR TREATMENT OF AUTISM SPECTRUM DISORDERS
Document Type and Number:
WIPO Patent Application WO/2023/120551
Kind Code:
A1
Abstract:
Provided are a novel pharmaceutical composition and method for treating and/or preventing autism spectrum disorders, fragile X syndrome, and/or autism spectrum disorder-like symptoms. Specifically provided is a pharmaceutical composition for treating and/or preventing autism spectrum disorders, fragile X syndrome, and/or autism spectrum disorder-like symptoms, the composition containing: buprenorphine or a pharmaceutically acceptable salt thereof; and/or morphine or a pharmaceutically acceptable salt thereof.
Inventors:
AGO YUKIO (JP)
YAMAKAWA HIDEKUNI (JP)
NAKAMURA ATSUSHI (JP)
YAMAKAWA HIDEKUNI (JP)
NAKAMURA ATSUSHI (JP)
Application Number:
PCT/JP2022/047004
Publication Date:
June 29, 2023
Filing Date:
December 21, 2022
Export Citation:
Assignee:
UNIV OSAKA (JP)
SHIONOGI & CO (JP)
SHIONOGI & CO (JP)
International Classes:
A61K31/485; A61P25/18
Foreign References:
| JP2019089755A | 2019-06-13 | |||
| JP2014532703A | 2014-12-08 | |||
| JP2013544780A | 2013-12-19 |
Other References:
THORNTON, AOIFE M.; HUMPHREY, RACHEL M.; KERR, DANIEL M.; FINN, DAVID P.; ROCHE, MICHELLE: "Effects of pharmacological modulation of the endogenous opioid and cannabinoid systems on affective responding in a rat model of autism", BRAIN AND NEUROSCIENCE ADVANCES, SAGE PUBLISHING, vol. 3, 1 January 2019 (2019-01-01), pages 146, XP009547339, ISSN: 2398-2128
YAMAGUCHI, TAKU; YOSHIOKA, MITSUHIRO: "Evaluation for anxiety-related behaviors in rodents", NIHON NAIBUNPI GAKKAI ZASSHI - FOLIA ENDOCRINOLOGICA JAPONICA, NIHON NAIBUNPI GAKKAI, JP, vol. 130, no. 2, 1 January 2007 (2007-01-01), JP , pages 105 - 111, XP009547338, ISSN: 0029-0661, DOI: 10.1254/fpj.130.105
SKOGLUND CHARLOTTE, LEKNES SIRI, HEILIG MARKUS: "The partial ยต-opioid agonist buprenorphine in autism spectrum disorder: a case report", JOURNAL OF MEDICAL CASE REPORTS, vol. 16, no. 1, 1 December 2022 (2022-12-01), XP093074740, DOI: 10.1186/s13256-022-03384-w
YAMAGUCHI, TAKU; YOSHIOKA, MITSUHIRO: "Evaluation for anxiety-related behaviors in rodents", NIHON NAIBUNPI GAKKAI ZASSHI - FOLIA ENDOCRINOLOGICA JAPONICA, NIHON NAIBUNPI GAKKAI, JP, vol. 130, no. 2, 1 January 2007 (2007-01-01), JP , pages 105 - 111, XP009547338, ISSN: 0029-0661, DOI: 10.1254/fpj.130.105
SKOGLUND CHARLOTTE, LEKNES SIRI, HEILIG MARKUS: "The partial ยต-opioid agonist buprenorphine in autism spectrum disorder: a case report", JOURNAL OF MEDICAL CASE REPORTS, vol. 16, no. 1, 1 December 2022 (2022-12-01), XP093074740, DOI: 10.1186/s13256-022-03384-w
Attorney, Agent or Firm:
SUGITA Ken-ichi et al. (JP)
Download PDF: