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Title:
USE OF PERSISTENT FREE RADICALS IN MAGNETIC RESONANCE IMAGING
Document Type and Number:
WIPO Patent Application WO1993002710
Kind Code:
A3
Inventors:
ANDERSSON SVEN (SE)
RISE FRODE (SE)
WISTRAND LARS-GOERAN (SE)
WIKSTROEM HAAKAN (SE)
Application Number:
EP9201792W
Publication Date:
March 18, 1993
Filing Date:
August 06, 1992
Export Citation:
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Assignee:
NYCOMED INNOVATION AB
International Classes:
A61K49/20; C07C45/67; C07C45/70; C07C46/00; C07C49/753; C07C50/28; C07C69/92; C07C235/48; C07C255/36; C07C255/41; C07C309/66; C07C317/22; C07C323/20; C07D209/48; C07D215/24; C07D339/06; C07D471/04; C07D493/04; C07D497/04; C07D519/00; (IPC1-7): A61K49/00
Domestic Patent References:
WO1991012024A11991-08-22
Other References:
Magnetic Resonance in Medicine, vol. 14, 1990, Academic Press, Inc., D. GRUCKER: "Communications, in vivo detection of injected free radicals by overhauser effect imaging", pages 140-147, see page 145: "Discussion"
Journal of Magnetic Resonance, vol. 76, 1988, Academic Press, Inc., D.J. LURIE et al.: "Communications, proton-electron double magnetic resonance imaging of free radical solutions", pages 366-370, see paragraph 1; page 369, last paragraph
STN File Server & File CA & Chemical Abstracts, vol. 96, no. 10, (Columbus, Ohio, US), T. NAGAMURA et al.: "ESR studies on free radicals generated in poly(p-(2-hydroxyethoxy)benzoic acid) fibers at low temperatures", see abstract no. 70290a, & POLYMER, 1981, 22(9), 1267-71, see whole abstract
STN File Server & File CA & Chemical Abstracts, vol. 94, no. 22, (Columbus, Ohio, US), R.W. FESSENDEN et al.: "Electron spin-lattice relaxation times of transient free radicals", see abstract no. 183019w, & J. CHEM. PHYS., 1981, 74(7), 3694-704, see whole abstract
STN File Server & File CA & Chemical Abstracts, vol. 83, no. 10, (Columbus, Ohio, US), S. CLOUGH et al.: "Double-resonance detection of tunneling sidebands of electron-spin resonance spectrum", see abstract no. 88194p, & J. PHYS. C, 1975, 8(11), 1745-9, see whole abstract
The Journal of Biological Chemistry, vol. 264, no. 19, 5 July 1989, The American Society for Biochemistry and Molecular Biology, Inc., (US), B. KALYANARAMAN et al.: "Characterization of semiquinone free radicals formed from stilbene catechol estrogens", pages 11014-11019, see abstract; page 11014
J. Org. Chem., vol. 51, no. 24, 1986, American Chemical Society, D.H. WADSWORTH et al.: "Indolizines. 2. Preparation of 1- and 3-indolizinols and their esters", pages 4639-4644, see page 4639, column 2, last 6 lines (cited in the application)
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