Title:
USE OF PHTHALAZINE DERIVATIVES
Document Type and Number:
WIPO Patent Application WO2000067734
Kind Code:
A3
Abstract:
The invention relates to the use of phthalazine derivatives as inhibitors of the enzyme poly(ADP-ribose)polymerase or PARP (EC 2.4.2.30), and to their use as inhibitors of PARP-homologous enzymes. These phthalazine derivatives also exhibit, in particular, a selective inhibition of the PARP-homologous enzymes. The inventive phthalazine derivatives are used for producing medicaments used in the treatment of neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, stroke, cerebral trauma, epilepsy, damages to the kidney, cardiovascular diseases, tumors, rheumatic diseases, diabetes mellitus, etc.
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Inventors:
LUBISCH WILFRIED (DE)
SADOWSKI JENS (DE)
KOCK MICHAEL (DE)
HOEGER THOMAS (DE)
SADOWSKI JENS (DE)
KOCK MICHAEL (DE)
HOEGER THOMAS (DE)
Application Number:
PCT/EP2000/003967
Publication Date:
June 20, 2002
Filing Date:
May 03, 2000
Export Citation:
Assignee:
BASF AG (DE)
LUBISCH WILFRIED (DE)
SADOWSKI JENS (DE)
KOCK MICHAEL (DE)
HOEGER THOMAS (DE)
LUBISCH WILFRIED (DE)
SADOWSKI JENS (DE)
KOCK MICHAEL (DE)
HOEGER THOMAS (DE)
International Classes:
A61K31/502; A61P1/10; A61P9/00; A61P9/10; C07D237/32; A61P13/12; A61P17/02; A61P19/02; A61P25/00; A61P25/08; A61P25/10; A61P25/12; A61P25/14; A61P25/16; A61P25/28; A61P29/00; A61P31/04; A61P35/00; A61P35/04; A61P37/00; A61P41/00; A61P43/00; C07D401/12; C07D403/12; (IPC1-7): A61P9/00; A61P25/00; A61K31/495; A61K31/502
Domestic Patent References:
| WO1998045292A1 | 1998-10-15 | |||
| WO1999011649A2 | 1999-03-11 | |||
| WO2000005218A1 | 2000-02-03 | |||
| WO2000005219A1 | 2000-02-03 |
Foreign References:
| EP0722936A1 | 1996-07-24 | |||
| US4939140A | 1990-07-03 | |||
| GB2112389A | 1983-07-20 |
Other References:
BERNARD, A. M. ET AL: "A new and efficient synthesis of phthalazin-1(2H)-ones", SYNTHESIS (1998), (3), 317-320, XP001010445
MIYAZAKI, H. ET AL: "The use of stable isotopes in drug metabolism and pharmacokinetics", ADV. PHARMACOL. THER., PROC. INT. CONGR., 8TH (1982), MEETING DATE 1981, VOLUME 6, 227-33. EDITOR(S): YOSHIDA, HIROSHI: HAGIHARA, YASHIREO;EBASHI, SETSURO. PUBLISHER: PERGAMON, OXFORD, UK., XP001014487
MIYAZAKI, H. ET AL: "The use of stable isotopes in drug metabolism and pharmacokinetics", ADV. PHARMACOL. THER., PROC. INT. CONGR., 8TH (1982), MEETING DATE 1981, VOLUME 6, 227-33. EDITOR(S): YOSHIDA, HIROSHI: HAGIHARA, YASHIREO;EBASHI, SETSURO. PUBLISHER: PERGAMON, OXFORD, UK., XP001014487
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