Title:
USE OF POLYMERIZED HEMOGLOBIN IN PREPARATION OF DRUG FOR TREATING ISCHEMIC STROKE
Document Type and Number:
WIPO Patent Application WO/2023/087421
Kind Code:
A1
Abstract:
Provided is the use of polymerized hemoglobin in the preparation of a drug for treating an ischemic stroke. The drug is a hemoglobin oxygen carrier and is also a colloid solution, and the particle size of the polymerized hemoglobin is only one-thousandth of that of a red blood cell. Small-dose perfusion does not bring about tissue damage and cell death caused by reperfusion to the brain, but can relieve the "blood supply shortage" caused by arterial blockages. At the same time, hemoglobin performs oxygen loading and unloading from the lung to the tissue and organs, which specifically blocks the pathophysiological process caused by ischemia and hypoxia in the brain, saves nerve cells in the ischemic penumbra, reduces the mortality of the nerve cells, and achieves a neuroprotective effect. A neuroprotective agent can also be added to the drug to prepare a compound drug, which has a more obvious protective effect on nerve cells in the ischemic penumbra and can prolong the 6 h stroke "therapeutic window" of rt-PA intravenous thrombolysis.
Inventors:
YOU KEWEI (CN)
LI JIANBO (CN)
ZHANG YANPENG (CN)
SHI SONG (CN)
WANG WENGANG (CN)
LI JIANBO (CN)
ZHANG YANPENG (CN)
SHI SONG (CN)
WANG WENGANG (CN)
Application Number:
PCT/CN2021/135671
Publication Date:
May 25, 2023
Filing Date:
December 06, 2021
Export Citation:
Assignee:
REDPHARM BEIJING BIOPHARMACEUTICAL INST CO LTD (CN)
REDPHARM BEIJING BIOTECHNOLOGY CO LTD (CN)
YOU KEWEI (CN)
REDPHARM BEIJING BIOTECHNOLOGY CO LTD (CN)
YOU KEWEI (CN)
International Classes:
A61K38/42; A61K9/10; A61K45/06; A61K47/02; A61K47/12; A61K47/18; A61P9/10; A61P25/00
Foreign References:
| US20040072729A1 | 2004-04-15 | |||
| CN110563836A | 2019-12-13 | |||
| US20190328892A1 | 2019-10-31 |
Other References:
"Master's Thesis", 30 June 2015, NORTHWEST UNIVERSITY, CN, article XIE, ZHILAN: "The Protective Effect of Polymerized Porcine Hemoglobin (pPolyHb) on Transient Focal Cerebral Ischemia-Reperfusion Injury", pages: 1 - 54, XP009545580
SAXENA, R. ET AL.: "Effect of diaspirin cross-linked hemoglobin on endothelin-1 and blood pressure in acute ischemic stroke in man.", JOURNAL OF HYPERTENSION, vol. 16, no. 10, 31 December 1998 (1998-12-31), pages 1459 - 1465, XP009545704
LYU, YANFENG ET AL.: "Subsequent Treatment with Intravenous Thrombolysis", TREATMENT STRATEGY FOR ACUTE STROKE REVASCULARIZATION, 30 June 2016 (2016-06-30), XP009545705
SAXENA, R. ET AL.: "Effect of diaspirin cross-linked hemoglobin on endothelin-1 and blood pressure in acute ischemic stroke in man.", JOURNAL OF HYPERTENSION, vol. 16, no. 10, 31 December 1998 (1998-12-31), pages 1459 - 1465, XP009545704
LYU, YANFENG ET AL.: "Subsequent Treatment with Intravenous Thrombolysis", TREATMENT STRATEGY FOR ACUTE STROKE REVASCULARIZATION, 30 June 2016 (2016-06-30), XP009545705
Attorney, Agent or Firm:
BEIJING CIPRUN INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)
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