Title:
USE OF PYRIDO`2,3-D PYRIMIDIN DERIVATIVES FOR THE TREATMENT OF HUMAN CYTOMEGALOVIRUS INFECTIONS
Document Type and Number:
WIPO Patent Application WO2002078709
Kind Code:
A3
Abstract:
The present invention provides a method for treating HCMV in a human requiring said treatment, which comprises administering to said human an effective amount of a compound of formula I: formula (I); where: Y is CH=CH, O, or S; R<3> is hydrogen, chloro, or fluoro; R<4> is hydroxy, a carboxy protecting group, or NHC*H(COOH)CH2CH2COOH where the configuration about the carbon atom designated * is S; and R<6> is hydrogen or an amino protecting group; and R<7> is hydroxy or amino; or a salt or solvate thereof.
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Inventors:
BALOGH DOUGLAS WAYNE (US)
COLACINO JOSEPH MATTHEW (US)
COLACINO JOSEPH MATTHEW (US)
Application Number:
PCT/US2002/001232
Publication Date:
May 22, 2003
Filing Date:
February 04, 2002
Export Citation:
Assignee:
LILLY CO ELI (US)
BALOGH DOUGLAS WAYNE (US)
COLACINO JOSEPH MATTHEW (US)
BALOGH DOUGLAS WAYNE (US)
COLACINO JOSEPH MATTHEW (US)
International Classes:
A61K31/519; A61P31/22; (IPC1-7): A61K31/519; A61P31/22
Domestic Patent References:
| WO1996003406A1 | 1996-02-08 |
Foreign References:
| US4684653A | 1987-08-04 | |||
| US4882334A | 1989-11-21 | |||
| US5625061A | 1997-04-29 |
Other References:
LEMBO D ET AL: "MURINE CYTOMEGALOVIRUS INDUCES EXPRESSION AND ENZYME ACTIVITY OF CELLULAR DIHYDROFOLATE REDUCTASE IN QUIESCENT CELLS", JOURNAL OF GENERAL VIROLOGY, READING, BERKS, GB, vol. 11, no. 79, November 1998 (1998-11-01), pages 2803 - 2807, XP001086683, ISSN: 0022-1317
GOSSETT LYNN S ET AL: "The synthesis and biological activity of a series of 2,4-diaminopyrido(2,3-D)pyrimidine based antifolates as antineoplastic and antiarthritic agents.", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 9, no. 1, 4 January 1999 (1999-01-04), pages 75 - 78, XP002216051, ISSN: 0960-894X
HABECK L L ET AL: "SUBSTRATE SPECIFICITY OF MAMMALIAN FOLYPOLYGLUTAMATE SYNTHETASE FOR 5,10-DIDEAZATETRAHYDROFOLATE ANALOGS", MOLECULAR PHARMACOLOGY, BALTIMORE, MD, US, vol. 2, no. 48, August 1995 (1995-08-01), pages 326 - 333, XP008006323, ISSN: 0026-895X
PIPER JAMES R ET AL: "Analogues of methotrexate in rheumatoid arthritis. 2. Effects of 5-deazaaminopterin, 5,10-dideazaaminopterin, and analogues on type II collagen-induced arthritis in mice.", JOURNAL OF MEDICINAL CHEMISTRY, vol. 40, no. 3, 1997, pages 377 - 384, XP002216052, ISSN: 0022-2623
SHANLEY J D ET AL: "THE FOLATE ANTAGONIST, METHOTREXATE, IS A POTENT INHIBITOR OF MURINE AND HUMAN CYTOMEGALOVIRUS IN VITRO", ANTIVIRAL RESEARCH, ELSEVIER SCIENCE BV., AMSTERDAM, NL, vol. 2, no. 11, March 1989 (1989-03-01), pages 99 - 106, XP008006327, ISSN: 0166-3542
GOSSETT LYNN S ET AL: "The synthesis and biological activity of a series of 2,4-diaminopyrido(2,3-D)pyrimidine based antifolates as antineoplastic and antiarthritic agents.", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 9, no. 1, 4 January 1999 (1999-01-04), pages 75 - 78, XP002216051, ISSN: 0960-894X
HABECK L L ET AL: "SUBSTRATE SPECIFICITY OF MAMMALIAN FOLYPOLYGLUTAMATE SYNTHETASE FOR 5,10-DIDEAZATETRAHYDROFOLATE ANALOGS", MOLECULAR PHARMACOLOGY, BALTIMORE, MD, US, vol. 2, no. 48, August 1995 (1995-08-01), pages 326 - 333, XP008006323, ISSN: 0026-895X
PIPER JAMES R ET AL: "Analogues of methotrexate in rheumatoid arthritis. 2. Effects of 5-deazaaminopterin, 5,10-dideazaaminopterin, and analogues on type II collagen-induced arthritis in mice.", JOURNAL OF MEDICINAL CHEMISTRY, vol. 40, no. 3, 1997, pages 377 - 384, XP002216052, ISSN: 0022-2623
SHANLEY J D ET AL: "THE FOLATE ANTAGONIST, METHOTREXATE, IS A POTENT INHIBITOR OF MURINE AND HUMAN CYTOMEGALOVIRUS IN VITRO", ANTIVIRAL RESEARCH, ELSEVIER SCIENCE BV., AMSTERDAM, NL, vol. 2, no. 11, March 1989 (1989-03-01), pages 99 - 106, XP008006327, ISSN: 0166-3542
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