Title:
USE OF RUBESCENSINE A AND DERIVATIVES THEREOF IN PHARMACY
Document Type and Number:
WIPO Patent Application WO/2008/022505
Kind Code:
A1
Abstract:
Use of rubescensine A and derivatives thereof in pharmacy. Rubescensine A can induce the apoptosis of leukemic cells in vitro, and can prolong the survival period of mouse model of t(8;21) leukemia in vivo or delay the growth of tumor in body. Sequential, joint application of rubescensine A and chemotherapeutics, such as cytarabine or agents for inducing differentiation may be more effective in prolonging the survival period of mouse of t(8;21) leukemia.
Inventors:
CHEN, Zhu (197 Rui Jin Er Road, Shanghai 5, 200025, CN)
陈竺 (中国上海市瑞金二路197号, Shanghai 5, 200025, CN)
CHEN, Saijuan (197 Rui Jin Er Road, Shanghai 5, 200025, CN)
陈赛娟 (中国上海市瑞金二路197号, Shanghai 5, 200025, CN)
陈竺 (中国上海市瑞金二路197号, Shanghai 5, 200025, CN)
CHEN, Saijuan (197 Rui Jin Er Road, Shanghai 5, 200025, CN)
陈赛娟 (中国上海市瑞金二路197号, Shanghai 5, 200025, CN)
Application Number:
CN2007/000380
Publication Date:
February 28, 2008
Filing Date:
February 05, 2007
Export Citation:
Assignee:
RUI JIN HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE (197 Rui Jin Er Road, Shanghai 5, 200025, CN)
上海交通大学医学院附属瑞金医院 (中国上海市瑞金二路197号, Shanghai 5, 200025, CN)
CHEN, Zhu (197 Rui Jin Er Road, Shanghai 5, 200025, CN)
陈竺 (中国上海市瑞金二路197号, Shanghai 5, 200025, CN)
CHEN, Saijuan (197 Rui Jin Er Road, Shanghai 5, 200025, CN)
上海交通大学医学院附属瑞金医院 (中国上海市瑞金二路197号, Shanghai 5, 200025, CN)
CHEN, Zhu (197 Rui Jin Er Road, Shanghai 5, 200025, CN)
陈竺 (中国上海市瑞金二路197号, Shanghai 5, 200025, CN)
CHEN, Saijuan (197 Rui Jin Er Road, Shanghai 5, 200025, CN)
International Classes:
A61K31/52; A61K31/202; A61K31/70; A61K38/19; A61P35/00; A61P35/02
Attorney, Agent or Firm:
ESSEN PATENT AGENCY (SHANGHAI) (36 Wuning Road, Shanghai 3, Shanghai 3, 200063, CN)
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