Title:
THE USE OF THE SALICYLATE AS AN ANTIDOTE FOR PARAQUAT INTOXICATIONS IN MAMMALS
Document Type and Number:
WIPO Patent Application WO2007132418
Kind Code:
B1
Abstract:
The present invention concerns to the use of salicylate in the treatment of mammal intoxications caused by the herbicide paraquat (PQ). It was achieved, for the first time, 100% of survival 30 days after the administration to Wistar rats, by intraperitoneal route, of a PQ dose that, in the absence of treatment, is itself 100% lethal at the end of 6 days. The administration of salicylate, two hours after PQ, reversed the PQ toxicity and extended the life of the animals to the levels of the control group.
Inventors:
DIAS CARVALHO FELIX (PT)
DINIS OLIVEIRA RICARDO JORGE (PT)
PINHO DE ALMEIDA SOUTEIRO BAST (PT)
GOMES REMIAO FERNANDO MANUEL (PT)
RAMOS DUARTE JOSE ALBERTO (PT)
SANCHEZ NAVARRO AMPARO (ES)
DINIS OLIVEIRA RICARDO JORGE (PT)
PINHO DE ALMEIDA SOUTEIRO BAST (PT)
GOMES REMIAO FERNANDO MANUEL (PT)
RAMOS DUARTE JOSE ALBERTO (PT)
SANCHEZ NAVARRO AMPARO (ES)
Application Number:
PCT/IB2007/051799
Publication Date:
June 05, 2008
Filing Date:
May 11, 2007
Export Citation:
Assignee:
UNIV DO PORTO (PT)
DIAS CARVALHO FELIX (PT)
DINIS OLIVEIRA RICARDO JORGE (PT)
PINHO DE ALMEIDA SOUTEIRO BAST (PT)
GOMES REMIAO FERNANDO MANUEL (PT)
RAMOS DUARTE JOSE ALBERTO (PT)
SANCHEZ NAVARRO AMPARO (ES)
DIAS CARVALHO FELIX (PT)
DINIS OLIVEIRA RICARDO JORGE (PT)
PINHO DE ALMEIDA SOUTEIRO BAST (PT)
GOMES REMIAO FERNANDO MANUEL (PT)
RAMOS DUARTE JOSE ALBERTO (PT)
SANCHEZ NAVARRO AMPARO (ES)
International Classes:
A61K31/616; A61P39/02
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