Title:
USE OF SE-DR AFFINITY PEPTIDE IN PREPARING DRUG FOR TREATING RHEUMATIC DISEASE
Document Type and Number:
WIPO Patent Application WO/2023/006125
Kind Code:
A1
Abstract:
Provided is a use of an SE-DR (shared epitope-containing HLA DR molecule) affinity peptide in preparing a drug for treating rheumatic disease in rheumatic disease patients who are tuberculosis positive and/or have hepatitis B, solving the problem of limited drug selection for these types of rheumatic disease patients. Also provided are a pharmaceutical composition including the SE-DR affinity peptide and a non-antigen-specific anti-rheumatic disease drug, and a use thereof in preparing a drug for treating various types of rheumatic disease. The pharmaceutical composition can rapidly inhibit the progress of rheumatic disease, and can implement sustained release after drug reduction and withdrawal, thereby achieving the goal of thoroughly controlling rheumatic disease.
Inventors:
LIU CHAO (CN)
HUANG LIJING (CN)
LI CHENHUI (CN)
JIANG ZHAOHONG (CN)
WANG FEI (CN)
WANG HONGQUAN (CN)
HUANG LIJING (CN)
LI CHENHUI (CN)
JIANG ZHAOHONG (CN)
WANG FEI (CN)
WANG HONGQUAN (CN)
Application Number:
PCT/CN2022/117495
Publication Date:
February 02, 2023
Filing Date:
September 07, 2022
Export Citation:
Assignee:
HEBEI FITNESS BIOTECHNOLOGY CO LTD (CN)
International Classes:
A61K38/08; A61K38/10; A61K38/16; A61P1/16; A61P29/00; A61P31/20; C07K7/06; C07K7/08; C07K14/00
Foreign References:
| CN1386754A | 2002-12-25 | |||
| CN1868537A | 2006-11-29 | |||
| CN1872873A | 2006-12-06 | |||
| CN111868073A | 2020-10-30 | |||
| CN103163302A | 2013-06-19 | |||
| CN1935133A | 2007-03-28 |
Other References:
YAO Z.-Q., LI R., LI Z.-G.: "A triple altered collagen II peptide with consecutive substitutions of TCR contacting residues inhibits collagen-induced arthritis", ANNALS OF THE RHEUMATIC DISEASES, BRITISH MEDICAL ASSOCIATION, GB, vol. 66, no. 3, 1 March 2007 (2007-03-01), GB , pages 423 - 424, XP093028643, ISSN: 0003-4967, DOI: 10.1136/ard.2006.057927
LI ZHANGUO, HAN LEI , JIA RULIN, LI JING: "Impact of rheumatoid arthritis -associated HLA -DRĪ² 1subtypes on protein kinase A signaling", CHINESE MEDICAL JOURNAL, vol. 116, no. 5, 31 December 2003 (2003-12-31), pages 712 - 716, XP093028654
CHICZ, R. M. ET AL.: "Specificity and Promiscuity among Naturally Processed Peptides Bound to HLA-DR Alleles", JOURNAL OF EXPERIMENTAL MEDICINE, vol. 178, 31 July 1993 (1993-07-31), pages 27 - 47, XP002069888, DOI: 10.1084/jem.178.1.27
LI ZHANGUO, HAN LEI , JIA RULIN, LI JING: "Impact of rheumatoid arthritis -associated HLA -DRĪ² 1subtypes on protein kinase A signaling", CHINESE MEDICAL JOURNAL, vol. 116, no. 5, 31 December 2003 (2003-12-31), pages 712 - 716, XP093028654
CHICZ, R. M. ET AL.: "Specificity and Promiscuity among Naturally Processed Peptides Bound to HLA-DR Alleles", JOURNAL OF EXPERIMENTAL MEDICINE, vol. 178, 31 July 1993 (1993-07-31), pages 27 - 47, XP002069888, DOI: 10.1084/jem.178.1.27
Attorney, Agent or Firm:
BEIJING CEMO LEADER INTELLECTUAL PROPERTY AGENCY (CN)
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