Title:
USE OF SELENIUM FOR TREATING PATIENTS SUFFERING FROM SYSTEMIC INFLAMMATORY RESPONSE SYNDROME (SIRS), AND COMPOSITION FOR IMPLEMENTING SAID TREATMENT
Document Type and Number:
WIPO Patent Application WO2000012101
Kind Code:
A3
Abstract:
The invention concerns the use of at least a molecule containing selenium, in an amount corresponding to a daily dose of about 2 to 40 mg, even 80 mg of atomic selenium equivalent, on its own or combined with other synergetic molecules for controlling oxidative stress and excessive inflammatory reaction: zinc, vitamin E, vitamin C, iron binder, glutathione precursor, copper and/or copper input binder, for preparing a medicine for treating severe systemic inflammatory response syndrome, in particular any acute infectious condition endangering the patient's life whether of bacterial, parasitic, fungal or viral origin, and any condition corresponding to a severe onset of inflammatory pathology bringing about an exacerbation of cytokine secretion. The invention is applicable in human and veterinary medicine.
Inventors:
FORCEVILLE XAVIER (FR)
VITOUX DOMINIQUE (FR)
VITOUX DOMINIQUE (FR)
Application Number:
PCT/FR1999/002066
Publication Date:
June 15, 2000
Filing Date:
August 30, 1999
Export Citation:
Assignee:
FORCEVILLE XAVIER (FR)
VITOUX DOMINIQUE (FR)
VITOUX DOMINIQUE (FR)
International Classes:
A61K31/198; A61K31/355; A61K31/375; A61K33/04; A61K33/26; A61K33/30; A61K33/34; A61P29/00; A61P31/04; A61P31/10; A61P31/12; A61P33/10; (IPC1-7): A61K33/04
Domestic Patent References:
| WO1996030007A1 | 1996-10-03 |
Other References:
ZIMMERMANN T ET AL: "Selensubstitution bei Sepsispatienten. Eine prospektiv randomisierte Studie.", MED KLIN, SEP 15 1997, 92 SUPPL 3 P3-4, GERMANY, XP002105157
GARTNER R. ET AL: "SELENSUBSTITUTION BEI SEPSISPATIENTEN", MEDIZINISCHE KLINIK(MED. KLIN.), 92/SUPPL. 3 (12-14), Germany, XP002105158
BORNER J ET AL: "Selensubstitution bei schweren entzundlichen chirurgischen Krankheitsbildern sowie Verbrennungen und Verbruhungen im Kindesalter.", MED KLIN, SEP 15 1997, 92 SUPPL 3 P17-9, GERMANY, XP002105159
GARTNER R. ET AL: "SELENSUBSTITUTION BEI SEPSISPATIENTEN", MEDIZINISCHE KLINIK(MED. KLIN.), 92/SUPPL. 3 (12-14), Germany, XP002105158
BORNER J ET AL: "Selensubstitution bei schweren entzundlichen chirurgischen Krankheitsbildern sowie Verbrennungen und Verbruhungen im Kindesalter.", MED KLIN, SEP 15 1997, 92 SUPPL 3 P17-9, GERMANY, XP002105159
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