Title:
USE OF SESQUITERPENES FOR INHIBITING OXIDATIVE ENZYMES
Document Type and Number:
WIPO Patent Application WO1996035415
Kind Code:
A3
Abstract:
PCT No. PCT/GB96/01118 Sec. 371 Date Apr. 10, 1998 Sec. 102(e) Date Apr. 10, 1998 PCT Filed May 9, 1996 PCT Pub. No. WO96/35415 PCT Pub. Date Nov. 14, 1996The invention relates to the use of a sesquiterpene for inhibiting an oxidative enzyme, preferably a cytochrome P450 enzyme. The invention also relates to compositions comprising a sesquiterpene and a drug which exhibits instability in the presence of an oxidative enzyme.
Inventors:
SIME JOHN THOMAS (GB)
CHEETHAM PETER SAMUEL JAMES (GB)
GRADLEY MICHELLE LORRAINE (GB)
BANISTER NIGEL ERIC (GB)
CHEETHAM PETER SAMUEL JAMES (GB)
GRADLEY MICHELLE LORRAINE (GB)
BANISTER NIGEL ERIC (GB)
Application Number:
PCT/GB1996/001118
Publication Date:
February 06, 1997
Filing Date:
May 09, 1996
Export Citation:
Assignee:
ZYLEPSIS LTD (GB)
SIME JOHN THOMAS (GB)
CHEETHAM PETER SAMUEL JAMES (GB)
GRADLEY MICHELLE LORRAINE (GB)
BANISTER NIGEL ERIC (GB)
SIME JOHN THOMAS (GB)
CHEETHAM PETER SAMUEL JAMES (GB)
GRADLEY MICHELLE LORRAINE (GB)
BANISTER NIGEL ERIC (GB)
International Classes:
A61K31/015; A61K31/045; A61K31/122; A61K31/335; A61K31/44; G01N33/15; A61K38/00; A61K38/13; A61K38/43; A61K45/00; C07J1/00; (IPC1-7): A61K31/045; A61K31/12; A61K31/44; A61K31/335; A61K31/13
Other References:
DATABASE WPI Section Ch Week 8630, Derwent World Patents Index; Class B03, AN 86-194736, XP002020435
DATABASE WPI Section Ch Week 8344, Derwent World Patents Index; Class B05, AN 83-805379, XP002020436
DATABASE WPI Section Ch Week 9303, Derwent World Patents Index; Class B05, AN 93-021395, XP002020437
BELISARIO M.A. ET AL: "Effect of avarol, avarone and nine of their natural and synthetic derivatives on microsomal drug-metabolizing enzymes", TOXICOL. LETT., 1991, 57/2 (183-193), NETHERLANDS, XP000612517
CHAPMAN DE ET AL: "In vivo and in vitro effects of helenalin on mouse hepatic microsomal cytochrome P450.", BIOCHEM PHARMACOL, JAN 15 1991, 41 (2) P229-35, ENGLAND, XP000612516
CHAPMAN D.E. ET AL: "In vitro inhibition of mouse hepatic mixed-function oxidase enzymes by helenalin and alantolactone", BIOCHEM. PHARMACOL., 1989, 38/22 (3913-3923), UNITED KINGDOM, XP000612509
KIM I C ET AL: "SUBCHRONIC TREATMENT WITH GOSSYPOL AND LIVER MICROSOMAL DRUG METABOLIZING ENZYME SYSTEM OF MALE HAMSTERS", ADV CONTRACEPT DELIVERY SYST, 3 (2-3). 1987. 183-194., XP000612494
SAMUELSSON G: "SESQUITERPENOIDS AND DITERPENOIDS WITH PHARMACOLOGICAL AND BIOLOGICAL ACTIVITIES", ACTA PHARM FENN, 101 (2). 1992. 33-44., XP000612512
DROR, Y. ET AL: "Stabilization of microbial cytochrome P-450 activity by creation of stationary-phase conditions in a continuously operated immobilized cell reactor", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, vol. 61, no. 3, March 1995 (1995-03-01), pages 855 - 859, XP000612511
YAMAHARA J ET AL: "ANTI-ULCER EFFECTS IN RATS OF BITTER CARDAMON CONSTITUENTS", CHEM PHARM BULL (TOKYO), 38 (11). 1990. 3053-3054., XP002020449
WILLERSHAUSEN, H. ET AL: "Enzymatische transformation von Valencen zu Nootkaton", CHEMIKER-ZEITUNG, vol. 115, no. 12, December 1991 (1991-12-01), pages 358 - 60, XP000611746
DUCHARME, M.P. ET AL: "Trough concentrations of cyclosporine in blood following administration with grapefruit juice", BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, vol. 36, 1993, pages 457 - 459, XP000612518
BAILEY, D.G. ET AL: "Grapefruit juice and drugs. How significant is this reaction?", CLINICAL PHARMACOKINETICS, vol. 26, no. 2, 1994, pages 91 - 98, XP000612514
DATABASE WPI Section Ch Week 8344, Derwent World Patents Index; Class B05, AN 83-805379, XP002020436
DATABASE WPI Section Ch Week 9303, Derwent World Patents Index; Class B05, AN 93-021395, XP002020437
BELISARIO M.A. ET AL: "Effect of avarol, avarone and nine of their natural and synthetic derivatives on microsomal drug-metabolizing enzymes", TOXICOL. LETT., 1991, 57/2 (183-193), NETHERLANDS, XP000612517
CHAPMAN DE ET AL: "In vivo and in vitro effects of helenalin on mouse hepatic microsomal cytochrome P450.", BIOCHEM PHARMACOL, JAN 15 1991, 41 (2) P229-35, ENGLAND, XP000612516
CHAPMAN D.E. ET AL: "In vitro inhibition of mouse hepatic mixed-function oxidase enzymes by helenalin and alantolactone", BIOCHEM. PHARMACOL., 1989, 38/22 (3913-3923), UNITED KINGDOM, XP000612509
KIM I C ET AL: "SUBCHRONIC TREATMENT WITH GOSSYPOL AND LIVER MICROSOMAL DRUG METABOLIZING ENZYME SYSTEM OF MALE HAMSTERS", ADV CONTRACEPT DELIVERY SYST, 3 (2-3). 1987. 183-194., XP000612494
SAMUELSSON G: "SESQUITERPENOIDS AND DITERPENOIDS WITH PHARMACOLOGICAL AND BIOLOGICAL ACTIVITIES", ACTA PHARM FENN, 101 (2). 1992. 33-44., XP000612512
DROR, Y. ET AL: "Stabilization of microbial cytochrome P-450 activity by creation of stationary-phase conditions in a continuously operated immobilized cell reactor", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, vol. 61, no. 3, March 1995 (1995-03-01), pages 855 - 859, XP000612511
YAMAHARA J ET AL: "ANTI-ULCER EFFECTS IN RATS OF BITTER CARDAMON CONSTITUENTS", CHEM PHARM BULL (TOKYO), 38 (11). 1990. 3053-3054., XP002020449
WILLERSHAUSEN, H. ET AL: "Enzymatische transformation von Valencen zu Nootkaton", CHEMIKER-ZEITUNG, vol. 115, no. 12, December 1991 (1991-12-01), pages 358 - 60, XP000611746
DUCHARME, M.P. ET AL: "Trough concentrations of cyclosporine in blood following administration with grapefruit juice", BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, vol. 36, 1993, pages 457 - 459, XP000612518
BAILEY, D.G. ET AL: "Grapefruit juice and drugs. How significant is this reaction?", CLINICAL PHARMACOKINETICS, vol. 26, no. 2, 1994, pages 91 - 98, XP000612514
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