Title:
THE USE OF SIRNA SILENCING IN THE PREVENTION OF METASTASIS
Document Type and Number:
WIPO Patent Application WO2005040187
Kind Code:
A3
Abstract:
The present invention relates to synthesised RNAs, more specifically short interfering RNAs (siRNAs) that are able to modulate the expression of Tissue Factor (TF) and the use thereof in the prevention of metastasis and treatment of cancer.
Inventors:
PRYDZ HANS (NO)
HOLEN TORGEIR (NO)
AMARZGUIOUI MOHAMMED (NO)
HOLEN TORGEIR (NO)
AMARZGUIOUI MOHAMMED (NO)
Application Number:
PCT/NO2004/000238
Publication Date:
September 01, 2005
Filing Date:
August 05, 2004
Export Citation:
Assignee:
PRYDZ HANS (NO)
HOLEN TORGEIR (NO)
AMARZGUIOUI MOHAMMED (NO)
HOLEN TORGEIR (NO)
AMARZGUIOUI MOHAMMED (NO)
International Classes:
A61K48/00; C07H21/00; C12N15/113; A61K38/00; (IPC1-7): C12N15/11; A61K31/713; A61P35/04; C07H21/00
Domestic Patent References:
| WO2003066650A2 | 2003-08-14 |
Foreign References:
| US20050096289A1 | 2005-05-05 |
Other References:
MUELLER BARBARA M ET AL: "Expression of tissue factor by melanoma cells promotes efficient hematogenous metastasis", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 89, no. 24, 1992, pages 11832 - 11836, XP002332134, ISSN: 0027-8424
HOLEN T ET AL: "Positional effects of short interfering RNAs targeting the human coagulation trigger Tissue Factor", NUCLEIC ACIDS RESEARCH, vol. 30, no. 8, 15 April 2002 (2002-04-15), pages 1757 - 1766, XP002232890, ISSN: 0305-1048
AMARZGUIOUI M ET AL: "Tolerance for mutations and chemical modifications in a siRNA", NUCLEIC ACIDS RESEARCH, vol. 31, no. 2, 15 January 2003 (2003-01-15), pages 589 - 595, XP002270887, ISSN: 0305-1048
RUF W ET AL: "Tissue factor in cancer angiogenesis and metastasis.", CURRENT OPINION IN HEMATOLOGY, vol. 3, no. 5, September 1996 (1996-09-01), pages 379 - 384, XP008048554, ISSN: 1065-6251
HOLEN T ET AL: "Similar behaviour of single-strand and double-strand siRNAs suggests they act through a common RNAi pathway", NUCLEIC ACIDS RESEARCH, vol. 31, no. 9, 1 May 2003 (2003-05-01), pages 2401 - 2407, XP002281439, ISSN: 0305-1048
CAMERER E ET AL: "CELL BIOLOGY OF TISSUE FACTOR, THE PRINCIPAL INITIATOR OF BLOOD COAGULATION", THROMBOSIS RESEARCH, vol. 81, no. 1, January 1996 (1996-01-01), pages 1 - 41, XP002042582, ISSN: 0049-3848
See also references of EP 1660658A2
HOLEN T ET AL: "Positional effects of short interfering RNAs targeting the human coagulation trigger Tissue Factor", NUCLEIC ACIDS RESEARCH, vol. 30, no. 8, 15 April 2002 (2002-04-15), pages 1757 - 1766, XP002232890, ISSN: 0305-1048
AMARZGUIOUI M ET AL: "Tolerance for mutations and chemical modifications in a siRNA", NUCLEIC ACIDS RESEARCH, vol. 31, no. 2, 15 January 2003 (2003-01-15), pages 589 - 595, XP002270887, ISSN: 0305-1048
RUF W ET AL: "Tissue factor in cancer angiogenesis and metastasis.", CURRENT OPINION IN HEMATOLOGY, vol. 3, no. 5, September 1996 (1996-09-01), pages 379 - 384, XP008048554, ISSN: 1065-6251
HOLEN T ET AL: "Similar behaviour of single-strand and double-strand siRNAs suggests they act through a common RNAi pathway", NUCLEIC ACIDS RESEARCH, vol. 31, no. 9, 1 May 2003 (2003-05-01), pages 2401 - 2407, XP002281439, ISSN: 0305-1048
CAMERER E ET AL: "CELL BIOLOGY OF TISSUE FACTOR, THE PRINCIPAL INITIATOR OF BLOOD COAGULATION", THROMBOSIS RESEARCH, vol. 81, no. 1, January 1996 (1996-01-01), pages 1 - 41, XP002042582, ISSN: 0049-3848
See also references of EP 1660658A2
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