Title:
USE OF SMALL MOLECULE INHIBITORS TARGETING EYA TYROSINE PHOSPHATASE
Document Type and Number:
WIPO Patent Application WO/2014/113407
Kind Code:
A3
Abstract:
Inhibitors of EYA tyrosine phosphatase having the structure of Formula I are provided herein. The compounds are useful fo the treatment of certain proliferative diseases and cancer.
Inventors:
HEGDE RASHMI (US)
Application Number:
PCT/US2014/011539
Publication Date:
September 12, 2014
Filing Date:
January 14, 2014
Export Citation:
Assignee:
CHILDRENS HOSP MEDICAL CENTER (US)
International Classes:
C07D307/80; A61K31/34; A61P35/00
Domestic Patent References:
| WO2003073987A2 | 2003-09-12 | |||
| WO2012048058A2 | 2012-04-12 |
Foreign References:
| FR1260578A | 1961-04-04 | |||
| US6166069A | 2000-12-26 |
Other References:
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WROBEL JAY ET AL: "PTP1B inhibition and antihyperglycemic activity in the ob/ob mouse model of novel 11-arylbenzo(b)naphtho(2,3-d)furans and 11-arylbenzo(b)naphtho(2,3-d)thiophenes", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 42, no. 17, 26 August 1999 (1999-08-26), pages 3199 - 3202, XP002181876, ISSN: 0022-2623, DOI: 10.1021/JM990260V
CLAEYS N ET AL: "Recherches dans la série des benzo (b) thioph GBP enes. 1. - (Dialkylaminoalkyloxy-4 halogéno-3,5 benzoyl)- 2 ou 3 benzo (b) thioph GBP enes = RESEARCH IN THE SERIES OF BENZO-B-THIOPHENES PART 1 2 OR 3-4 DI ALKYLAMINOALKYLOXY-3 5-HALOGENOBENZOYL BENZO-B-THIOPHENES", CHIMIE THERAPEUTIQUE, EDITIONS DIMEO, ARCUEIL, FR, vol. 7, no. 5, 1 January 1972 (1972-01-01), pages 377 - 384, XP009177103, ISSN: 0009-4374
CHARLES W. LOCUSON ET AL: "Charge and Substituent Effects on Affinity and Metabolism of Benzbromarone-Based CYP2C19 Inhibitors", JOURNAL OF MEDICINAL CHEMISTRY, vol. 47, no. 27, 1 December 2004 (2004-12-01), pages 6768 - 6776, XP055109288, ISSN: 0022-2623, DOI: 10.1021/jm049605m
M. F. WEMPE ET AL: "Human Uric Acid Transporter 1 (hURAT1): An Inhibitor Structure-Activity Relationship (SAR) Study", NUCLEOSIDES, NUCLEOTIDES & NUCLEIC ACIDS, vol. 30, no. 12, 1 December 2011 (2011-12-01), pages 1312 - 1323, XP055109292, ISSN: 1525-7770, DOI: 10.1080/15257770.2011.594031
BO CARLSSON ET AL: "Synthesis and preliminary characterization of a novel antiarrhythmic compound (KB130015) with an improved toxicity profile compared with amiodarone", JOURNAL OF MEDICINAL CHEMISTRY, 31 January 2002 (2002-01-31), United States, pages 623 - 630, XP055109284, Retrieved from the Internet [retrieved on 20140320], DOI: 10.1021/jm001126+
WROBEL JAY ET AL: "PTP1B inhibition and antihyperglycemic activity in the ob/ob mouse model of novel 11-arylbenzo(b)naphtho(2,3-d)furans and 11-arylbenzo(b)naphtho(2,3-d)thiophenes", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 42, no. 17, 26 August 1999 (1999-08-26), pages 3199 - 3202, XP002181876, ISSN: 0022-2623, DOI: 10.1021/JM990260V
CLAEYS N ET AL: "Recherches dans la série des benzo (b) thioph GBP enes. 1. - (Dialkylaminoalkyloxy-4 halogéno-3,5 benzoyl)- 2 ou 3 benzo (b) thioph GBP enes = RESEARCH IN THE SERIES OF BENZO-B-THIOPHENES PART 1 2 OR 3-4 DI ALKYLAMINOALKYLOXY-3 5-HALOGENOBENZOYL BENZO-B-THIOPHENES", CHIMIE THERAPEUTIQUE, EDITIONS DIMEO, ARCUEIL, FR, vol. 7, no. 5, 1 January 1972 (1972-01-01), pages 377 - 384, XP009177103, ISSN: 0009-4374
CHARLES W. LOCUSON ET AL: "Charge and Substituent Effects on Affinity and Metabolism of Benzbromarone-Based CYP2C19 Inhibitors", JOURNAL OF MEDICINAL CHEMISTRY, vol. 47, no. 27, 1 December 2004 (2004-12-01), pages 6768 - 6776, XP055109288, ISSN: 0022-2623, DOI: 10.1021/jm049605m
M. F. WEMPE ET AL: "Human Uric Acid Transporter 1 (hURAT1): An Inhibitor Structure-Activity Relationship (SAR) Study", NUCLEOSIDES, NUCLEOTIDES & NUCLEIC ACIDS, vol. 30, no. 12, 1 December 2011 (2011-12-01), pages 1312 - 1323, XP055109292, ISSN: 1525-7770, DOI: 10.1080/15257770.2011.594031
BO CARLSSON ET AL: "Synthesis and preliminary characterization of a novel antiarrhythmic compound (KB130015) with an improved toxicity profile compared with amiodarone", JOURNAL OF MEDICINAL CHEMISTRY, 31 January 2002 (2002-01-31), United States, pages 623 - 630, XP055109284, Retrieved from the Internet
Attorney, Agent or Firm:
MILLER, Kimberly, J. (2040 Main Street14th Floo, Irvine CA, US)
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