Title:
USE FOR SPECIFIC ANTIBODY FOR ACTIVE OR LATENT TGF-β1
Document Type and Number:
WIPO Patent Application WO/2019/045086
Kind Code:
A1
Abstract:
The present invention provides an examination method for diagnosing cancer or fibrosis or diagnosing cancer malignancy or fibrosis progress, said examination method being characterized in that a sample from a person who has or may have cancer or fibrosis is made to come into contact with a first monoclonal antibody, which binds to active TGF-β1 but does not bind to latent TGF-β1 and includes (a1) a complementarity determining region (CDR) including the amino acid sequence represented by sequence number 1, (b1) a CDR including the amino acid sequence represented by sequence number 2, (c1) a CDR including the amino acid sequence represented by sequence number 3, (d1) a CDR including the amino acid sequence represented by sequence number 4, (e1) a CDR including the amino acid sequence represented by sequence number 5, and (f1) a CDR including the amino acid sequence represented by sequence number 6, and/or a second monoclonal antibody, which binds to latent TGF-β1 and LAP but does not bind to active TGF-β1 and includes (a2) a CDR including the amino acid sequence represented by sequence number 7, (b2) a CDR including the amino acid sequence represented by sequence number 8, (c2) a CDR including the amino acid sequence represented by sequence number 9, (d2) a CDR including the amino acid sequence represented by sequence number 10, (e2) a CDR including the amino acid sequence represented by sequence number 11, and (f2) a CDR including the amino acid sequence represented by sequence number 12, and the active TGF-β1 and/or latent TGF-β1 or LAP in the sample is specifically detected.
Inventors:
MIZUTANI TAKAYUKI (JP)
Application Number:
PCT/JP2018/032514
Publication Date:
March 07, 2019
Filing Date:
August 28, 2018
Export Citation:
Assignee:
HAYASHI KASEI CO LTD (JP)
International Classes:
G01N33/574; G01N33/53; G01N33/543; G01N33/577; C07K16/22; C12P21/08
Domestic Patent References:
| WO2016014565A2 | 2016-01-28 | |||
| WO2011102483A1 | 2011-08-25 |
Foreign References:
| JP2008505610A | 2008-02-28 | |||
| US20150132319A1 | 2015-05-14 | |||
| JP2008538564A | 2008-10-30 | |||
| JP2001526622A | 2001-12-18 | |||
| JP2014518064A | 2014-07-28 |
Attorney, Agent or Firm:
TAKASHIMA, Hajime et al. (JP)
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