Title:
USE OF SPORE OF CLOSTRIDIUM GHONII IN COMBINATION WITH PEMBROLIZUMAB
Document Type and Number:
WIPO Patent Application WO/2023/056962
Kind Code:
A1
Abstract:
The present invention relates to the use of Clostridium ghonii in combination with pembrolizumab in cancer therapy.
It is found for the first time in the present invention that Clostridium ghonii in combination with pembrolizumab can improve the efficacy thereof against colon cancer, while also reducing the dose of pembrolizumab, which is highly efficient and low toxicity.
Oncolysis with Clostridium ghonii can affect the immunogenicity of TME in various ways, so that TME is changed into an immune activation state from an immunosuppression state while the immunosuppressive TME is regulated, breaking through the immunological tolerance.
Approximately 20% of mouse tumor tissues are thoroughly removed by means of combining spores of Clostridium ghonii with pembrolizumab under optimal combination conditions, expanding the scope of benefits of the treatment of tumor patients with PD-1 antibodies, and also even providing efficacy for patients for which treatment with PD-1 antibodies has failed.
Inventors:
WANG YONG (CN)
ZHU HONG (CN)
ZHANG WENHUA (CN)
XING YANQIU (CN)
WANG DAN (CN)
LIU YUANYUAN (CN)
WANG SHAOPENG (CN)
ZHENG JIAHUI (CN)
ZHANG RONG (CN)
LI XIAONAN (CN)
XU XINGLU (CN)
JIANG SHENGBIAO (CN)
XING LICHAO (CN)
GAO YUXIA (CN)
SHAO SHILI (CN)
HAN TING (CN)
ZHU HONG (CN)
ZHANG WENHUA (CN)
XING YANQIU (CN)
WANG DAN (CN)
LIU YUANYUAN (CN)
WANG SHAOPENG (CN)
ZHENG JIAHUI (CN)
ZHANG RONG (CN)
LI XIAONAN (CN)
XU XINGLU (CN)
JIANG SHENGBIAO (CN)
XING LICHAO (CN)
GAO YUXIA (CN)
SHAO SHILI (CN)
HAN TING (CN)
Application Number:
PCT/CN2022/124020
Publication Date:
April 13, 2023
Filing Date:
October 09, 2022
Export Citation:
Assignee:
SHANDONG XINCHUANG BIOTECHNOLOGY CO LTD (CN)
International Classes:
A61K39/395; A61P35/00; C12R1/145
Foreign References:
| CN113995835A | 2022-02-01 | |||
| CN108102945A | 2018-06-01 | |||
| CN106265760A | 2017-01-04 | |||
| CN111629739A | 2020-09-04 | |||
| US20210000885A1 | 2021-01-07 | |||
| CN202111177854A | 2021-10-09 |
Attorney, Agent or Firm:
BEIJING GAOWO LAW FIRM (CN)
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