Title:
USE OF STATIN-BASED DRUG FOR TREATMENT OF EML4-ALK-POSITIVE NON-SMALL CELL LUNG CANCER RESISTANT TO ALK INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2017/123063
Kind Code:
A1
Abstract:
Provided according to the present invention is a pharmaceutical composition exhibiting therapeutic efficacy against EML4-ALK-positive non-small cell lung cancer that has acquired resistance to an ALK inhibitor. Also, provided is information for drug selection on the basis of which the administration of statin-based drugs to a patient group with EML4-ALK-positive non-small cell lung cancer can be determined.
Inventors:
CHO KYOUNG-JE (KR)
CHO BYOUNG CHUL (KR)
YOON MI-RAN (KR)
PYO KYOUNG-HO (KR)
KANG HAN NA (KR)
CHOI HUN-MI (KR)
CHO BYOUNG CHUL (KR)
YOON MI-RAN (KR)
PYO KYOUNG-HO (KR)
KANG HAN NA (KR)
CHOI HUN-MI (KR)
Application Number:
PCT/KR2017/000502
Publication Date:
July 20, 2017
Filing Date:
January 13, 2017
Export Citation:
Assignee:
UNIV-INDUSTRY FOUND YONSEI UNIV (KR)
JEUK CO LTD (KR)
JEUK CO LTD (KR)
International Classes:
A61K31/4418; A61K31/366; A61K31/40; A61K31/404; A61K31/505; G01N33/543; G01N33/574
Domestic Patent References:
| WO2011115725A2 | 2011-09-22 |
Other References:
CHEN, J. ET AL.: "Atorvastatin Overcomes Gefitinib Resistance in KRAS Mutant Human Non-small Cell Lung Carcinoma Cells", CELL DEATH AND DISEASE, vol. 4, no. e814, 2013, pages 1 - 13, XP055132861
SASAKI, T. ET AL.: "The Biology and Treatment of EMLA-ALK Non-small Cell Lung Cancer", EUROPEAN JOURNAL OF CANCER, vol. 46, 2010, pages 1773 - 1780, XP055399370
WARTTA, K. ET AL.: "Statin-induced Mevalonate Pathway Inhibition Attenuates the Growth of Mesenchymal-like Cancer Cells that Lack Functional E-cadherin Mediated Cell Cohesion", SCIENTIFIC REPORTS, vol. 4, no. 7593, 2014, pages 1 - 8, XP055399372
TAN, M. ET AL.: "Statins and the Risk of Lung Cancer: A Meta-analysis", PLOS ONE, vol. 8, no. 2, 2013, pages 1 - 9, XP055399375
SASAKI, T. ET AL.: "The Biology and Treatment of EMLA-ALK Non-small Cell Lung Cancer", EUROPEAN JOURNAL OF CANCER, vol. 46, 2010, pages 1773 - 1780, XP055399370
WARTTA, K. ET AL.: "Statin-induced Mevalonate Pathway Inhibition Attenuates the Growth of Mesenchymal-like Cancer Cells that Lack Functional E-cadherin Mediated Cell Cohesion", SCIENTIFIC REPORTS, vol. 4, no. 7593, 2014, pages 1 - 8, XP055399372
TAN, M. ET AL.: "Statins and the Risk of Lung Cancer: A Meta-analysis", PLOS ONE, vol. 8, no. 2, 2013, pages 1 - 9, XP055399375
Attorney, Agent or Firm:
DANA PATENT LAW FIRM (KR)
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