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Title:
USE OF SUBSTITUTED PYRROLIDINONES OR THEIR SALTS FOR INCREASING STRESS TOLERANCE OF PLANTS
Document Type and Number:
WIPO Patent Application WO/2022/268520
Kind Code:
A1
Abstract:
The invention relates to the use of substituted pyrrolidinones of general formula (I), or their salts, wherein the groups in general formula (I) are defined as indicated in the description, for increasing the stress tolerance of plants with respect to abiotic stress and/or for increasing the plant yield.

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JP2937589[Title of Invention] Cyclic imino derivatives, pharmaceutical compositions containing these compounds, and methods for preparing them.
Inventors:
FRACKENPOHL JENS (DE)
ARVE LARS (DE)
HELMKE HENDRIK (DE)
KUHN BIRGIT (DE)
SCHMIDT JANA (DE)
DITTGEN JAN (DE)
SCHMUTZLER DIRK (DE)
Application Number:
PCT/EP2022/065728
Publication Date:
December 29, 2022
Filing Date:
June 09, 2022
Export Citation:
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Assignee:
BAYER AG (DE)
International Classes:
C07D207/273; A01N43/36; A01N43/40; A01N43/42; A01N43/46; A01N43/54; A01N43/82; A01N47/18; A01P21/00; C07D401/12; C07D403/12
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Attorney, Agent or Firm:
BIP PATENTS (DE)
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Claims:
Patentansprüche 1. Verwendung substituierter Pyrrolidinone der allgemeinen Formel (I) oder deren Salze zur Steigerung der Stresstoleranz in Pflanzen gegenüber abiotischem Stress, sowie zur Steigerung des Pflanzenwachstums und/oder zur Erhöhung des Pflanzenertrags worin R1 für Wasserstoff, NR30R31, OR32, S(O)mR33, (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)- Alkinyl, (C1-C10)-Haloalkyl, (C2-C8)-Haloalkenyl, (C2-C8)-Haloalkinyl, (C3-C10)- Cycloalkyl, (C3-C10)-Halocycloalkyl, (C4-C10)-Cycloalkenyl, (C4-C10)-Halocycloalkenyl, Aryl, Aryl-(C1-C8)-Alkyl, Heteroaryl, Heteroaryl-(C1-C8)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C8)-Alkyl, R32O-(C1-C8)-Alkyl, R30R31N-(C1-C8)-Alkyl, R32O(O)C- (C1-C8)-Alkyl, R30R31N(O)C-(C1-C8)-Alkyl, (C3-C10)-Cycloalkyl-(C1-C8)-Alkyl, R33S(O)m-(C1-C8)-alkyl, R32(O=)C-(C1-C8)-Alkyl, C(=O)R32, C(=O)OR32 steht, m für 0, 1, 2 steht, R3 und R4 unabhängig voneinander für Wasserstoff, (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C1-C10)- Haloalkyl, (C3-C10)-Cycloalkyl, (C3-C10)-Cycloalkyl-(C1-C8)-Alkyl, Aryl-(C1-C8)-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C1-C8)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C8)-Alkyl, R32O-(C1-C8)-Alkyl, R30R31N-(C1-C8)-Alkyl stehen, R5, R6 unabhängig voneinander für Wasserstoff, (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C1-C10)- Haloalkyl, (C3-C10)-Cycloalkyl, Aryl-(C1-C8)-Alkyl, Aryl, Heteroaryl, Heteroaryl- (C1-C8)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C8)-Alkyl, R32O-(C1-C8)-Alkyl, R30R31N- (C1-C8)-Alkyl, NR30R31, OR32, (C3-C10)-Cycloalkyl-(C1-C8)-Alkyl stehen, R3 und R5 mit den Kohlenstoffatomen, an die sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 5 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, R2 für Wasserstoff und eine der nachfolgenden Gruppen G-1 bis G-2 steht, wobei ein Pfeil für eine Bindung zum Pyrrolidinonring in der allgemeinen Formel (I) steht, R7 für Wasserstoff und eine der nachfolgenden Gruppen G-1 bis G-15 steht, wobei ein Pfeil für eine Bindung zum Pyrrolidinonring in der allgemeinen Formel (I) steht, mit der Maßgabe, dass R2 und R7 nicht gleichzeitig H sind und dass R7 für H steht, wenn R2 für eine der nachfolgenden Gruppen G-1 bis G-2 steht, und dass R2 für H steht, wenn R7 für eine der nachfolgenden Gruppen G-1 bis G-15 steht, ( R8, R9, R10, R15, R18, R19, R20 unabhängig voneinander für Wasserstoff, (C1-C8)-Alkyl, (C2-C8)- Alkenyl, (C2-C8)-Alkinyl, Aryl-(C1-C8)-Alkyl, Heteroaryl-(C1-C8)-Alkyl, Heterocyclyl- (C1-C8)-Alkyl, R32O-(C1-C8)-Alkyl, (C3-C10)-Cycloalkyl-(C1-C8)-Alkyl, S(O)mR33, R32(O=)C-(C1-C8)-Alkyl, C(O=)R32, (C1-C8)-Alkyloxycarbonyl, Aryl-(C1-C8)- Alkyloxycarbonyl stehen, R8 und R9 mit den Stickstoffatomen, an die sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 5 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, R11, R12, R13, R14 unabhängig voneinander für Wasserstoff, (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkinyl, (C1-C10)-Haloalkyl, (C3-C10)-Cycloalkyl, Aryl-(C1-C8)-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C1-C8)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C8)-Alkyl, R32O- (C1-C8)-Alkyl, R30R31N-(C1-C8)-Alkyl, (C3-C10)-Cycloalkyl-(C1-C8)-Alkyl, C(=O)R32, C(=O)OR32, C(=O)NR30R31, R32O(O)C-(C1-C8)-Alkyl, R30R31N(O)C-(C1-C8)-Alkyl, OR32 stehen, R16, R17, R21, R22 unabhängig voneinander für Wasserstoff, (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkinyl, (C1-C10)-Haloalkyl, (C3-C10)-Cycloalkyl, Aryl-(C1-C8)-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C1-C8)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C8)-Alkyl, R32O- (C1-C8)-Alkyl, R30R31N-(C1-C8)-Alkyl, (C3-C10)-Cycloalkyl-(C1-C8)-Alkyl, C(=O)R32, C(=O)OR32, C(=O)NR30R31 stehen, R23, R24 unabhängig voneinander für Wasserstoff, (C1-C8)-Alkyl, (C1-C10)-Haloalkyl, (C3-C10)- Cycloalkyl, Aryl-(C1-C8)-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C1-C8)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C8)-Alkyl, R32O-(C1-C8)-Alkyl, R30R31N-(C1-C8)-Alkyl, (C3-C10)-Cycloalkyl-(C1-C8)-Alkyl, C(O=)R32, (C1-C8)-Alkyloxycarbonyl, Aryl-(C1-C8)- Alkyloxycarbonyl stehen, R25, R28, R29 nabhängig voneinander für Wasserstoff, (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)- Alkinyl, Aryl-(C1-C8)-Alkyl, Heteroaryl-(C1-C8)-Alkyl, Heterocyclyl-(C1-C8)-Alkyl, R32O-(C1-C8)-Alkyl, (C3-C10)-Cycloalkyl-(C1-C8)-Alkyl, R32(O=)C-(C1-C8)-Alkyl stehen, R26, R27 unabhängig voneinander für Wasserstoff, (C1-C8)-Alkyl, (C1-C10)-Haloalkyl, (C3-C10)- Cycloalkyl, (C3-C10)-Cycloalkyl-(C1-C8)-Alkyl, Aryl-(C1-C8)-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C1-C8)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C8)-Alkyl stehen, R30 und R31 unabhängig voneinander für Wasserstoff, (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)- Alkinyl, (C1-C8)-Cyanoalkyl, (C1-C10)-Haloalkyl, (C2-C8)-Haloalkenyl, (C3-C8)- Haloalkinyl, (C3-C10)-Cycloalkyl, (C3-C10)-Halocycloalkyl, (C4-C10)-Cycloalkenyl, (C4-C10)-Halocycloalkenyl, (C1-C8)-Alkoxy-(C1-C8)-alkyl, (C1-C8)-Haloalkoxy-(C1-C8)- alkyl, (C1-C8)-Alkylthio-(C1-C8)-alkyl, (C1-C8)-Haloalkylthio-(C1-C8)-alkyl, (C1-C8)- Alkoxy-(C1-C8)-haloalkyl, Aryl, Aryl-(C1-C8)-alkyl, Heteroaryl, Heteroaryl-(C1-C8)- alkyl, (C3-C8)-Cycloalkyl-(C1-C8)-alkyl, (C4-C10)-Cycloalkenyl-(C1-C8)-alkyl, COR32, SO2R33, Heterocyclyl, (C1-C8)-Alkoxycarbonyl, Bis-[(C1-C8)-alkyl]aminocarbonyl- (C1-C8)-alkyl, (C1-C8)-Alkyl-aminocarbonyl-(C1-C8)-alkyl, Aryl-(C1-C8)-alkyl- aminocarbonyl-(C1-C8)-alkyl, Aryl-(C1-C8)-alkoxycarbonyl, Heteroaryl-(C1-C8)- alkoxycarbonyl, (C2-C8)-Alkenyloxycarbonyl, (C2-C8)-Alkinyloxycarbonyl, Heterocyclyl-(C1-C8)-alkyl, (C1-C8)-Alkoxycarbonyl-(C1-C8)-alkyl, (C2-C8)- Alkenyloxycarbonyl-(C1-C8)-alkyl, (C2-C8)-Alkinyloxycarbonyl-(C1-C8)-alkyl, Aryl-(C1-C8)-alkoxycarbonyl-(C1-C8)-alkyl, Heteroaryl-(C1-C8)-alkoxycarbonyl- (C1-C8)-alkyl, Heterocyclyl-(C1-C8)-alkoxycarbonyl-(C1-C8)-alkyl stehen, oder R30 und R31 mit dem Stickstoffatom, an das sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 3 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, R32 für Wasserstoff, (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkinyl, (C1-C8)-Cyanoalkyl, (C1-C10)-Haloalkyl, (C2-C8)-Haloalkenyl, (C3-C8)-Haloalkinyl, (C3-C10)-Cycloalkyl, (C3-C10)-Halocycloalkyl, (C4-C10)-Cycloalkenyl, (C4-C10)-Halocycloalkenyl, (C1-C8)- Alkoxy-(C1-C8)-alkyl, (C1-C8)-Haloalkoxy-(C1-C8)-alkyl, (C1-C8)-Alkoxy-(C1-C8)- haloalkyl, (C1-C8)-Alkoxy-(C1-C8)-alkoxy-(C1-C8)-alkyl, (C1-C8)-Alkoxy-(C1-C8)- alkoxy-(C1-C8)-alkoxy-(C1-C8)-alkyl, (C1-C8)-Alkoxy-(C1-C8)-alkoxy-(C1-C8)-alkoxy- (C1-C8)-alkoxy-(C1-C8)-alkyl, Aryl, Aryl-(C1-C8)-alkyl, Aryl-(C1-C8)-alkoxy-(C1-C8)- alkyl, Heteroaryl, Heteroaryl-(C1-C8)-alkyl, (C3-C8)-Cycloalkyl-(C1-C8)-alkyl, (C4-C10)- Cycloalkenyl-(C1-C8)-alkyl, Bis-[(C1-C8)-alkyl]aminocarbonyl-(C1-C8)-alkyl, (C1-C8)- Alkyl-aminocarbonyl-(C1-C8)-alkyl, Aryl-(C1-C8)-alkyl-aminocarbonyl-(C1-C8)-alkyl, Bis-[(C1-C8)-alkyl]amino-(C2-C6)-alkyl, (C1-C8)-Alkyl-amino-(C2-C6)-alkyl, Aryl-(C1- C8)-alkyl-amino-(C2-C6)-alkyl, R33(O)mS-(C1-C8)-alkyl, Hydroxycarbonyl-(C1-C8)-alkyl, Heterocyclyl, Heterocyclyl-(C1-C8)-alkyl, Tris-[(C1-C8)-Alkyl]silyl-(C1-C8)-alkyl, Bis- [(C1-C8)-Alkyl](aryl)silyl(C1-C8)-alkyl, [(C1-C8)-Alkyl]-bis-(aryl)silyl-(C1-C8)-alkyl, (C1-C8)-Alkylcarbonyloxy-(C1-C8)-alkyl, (C3-C8)-Cycloalkylcarbonyloxy-(C1-C8)-alkyl, Arylcarbonyloxy-(C1-C8)-alkyl, Heteroarylcarbonyloxy-(C1-C8)-alkyl, Heterocyclylcarbonyloxy-(C1-C8)-alkyl, Aryloxy-(C1-C8)-alkyl, Heteroaryloxy-(C1-C8)- alkyl, Heterocyclyloxy-(C1-C8)-alkyl, (C1-C8)-Alkoxycarbonyl, (C1-C8)- Alkoxycarbonyl-(C1-C8)-alkyl, (C2-C8)-Alkenyloxycarbonyl-(C1-C8)-alkyl, (C2-C8)-Alkinyloxycarbonyl-(C1-C8)-alkyl, Aryl-(C1-C8)-alkoxycarbonyl- (C1-C8)-alkyl, Heteroaryl-(C1-C8)-alkoxycarbonyl-(C1-C8)-alkyl, Heterocyclyl- (C1-C8)-alkoxycarbonyl-(C1-C8)-alkyl steht, R33 für Wasserstoff, (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkinyl, (C1-C8)-Cyanoalkyl, (C1-C10)-Haloalkyl, (C2-C8)-Haloalkenyl, (C3-C8)-Haloalkinyl, (C3-C10)-Cycloalkyl, (C3-C10)-Halocycloalkyl, (C4-C10)-Cycloalkenyl, (C4-C10)-Halocycloalkenyl, (C1-C8)- Alkoxy-(C1-C8)-alkyl, (C1-C8)-Alkoxy-(C1-C8)-haloalkyl, Aryl, Aryl-(C1-C8)-alkyl, Heteroaryl, Heteroaryl-(C1-C8)-alkyl, Heterocyclyl-(C1-C8)-alkyl, (C3-C8)-Cycloalkyl- (C1-C8)-alkyl, (C4-C10)-Cycloalkenyl-(C1-C8)-alkyl, Bis-[(C1-C8)-alkyl]amino, (C1-C8)- Alkyl-amino, Aryl-(C1-C8)-amino, Aryl-(C1-C6)-alkyl-amino, Aryl-[(C1-C8)- alkyl]amino; Heteroaryl-(C1-C8)-amino, Heteroaryl-(C1-C6)-alkyl-amino, Heteroaryl- [(C1-C8)-alkyl]amino; Hetercyclyl-(C1-C8)-amino, Heterocyclyl-(C1-C6)-alkyl-amino, Heterocyclyl-[(C1-C8)-alkyl]amino; (C3-C8)-Cycloalkyl-amino, (C3-C8)-Cycloalkyl-[(C1- C8)-alkyl]amino; N-Azetidinyl, N-Pyrrolidinyl, N-Piperidinyl. N-Morpholinyl steht. R34 für Wasserstoff, (C1-C8)-Alkyl, (C2-C8)-Alkenyl, Aryl-(C1-C8)-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C1-C8)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C8)-Alkyl, R32O-(C1-C8)- Alkyl, R30R31N-(C1-C8)-Alkyl, NR30R31, (C3-C10)-Cycloalkyl-(C1-C8)-Alkyl, S(O)mR33 steht, R35 für Wasserstoff, NR30R31, OR32, (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkinyl, Aryl, Aryl-(C1-C8)-Alkyl, Heteroaryl, Heteroaryl-(C1-C8)-Alkyl, Heterocyclyl, Heterocyclyl- (C1-C8)-Alkyl, R32O-(C1-C8)-Alkyl, (C3-C10)-Cycloalkyl, (C3-C10)-Cycloalkyl-(C1-C8)- Alkyl, S(O)mR33, R32(O=)C-(C1-C8)-Alkyl, R32O(O)C-(C1-C8)-Alkyl, R30R31N(O)C- (C1-C8)-Alkyl, R33S(O)m-(C1-C8)-alkyl, R32O-(C1-C8)-Alkyl, R30R31N-(C1-C8)-Alkyl steht, R36 für Wasserstoff, (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkinyl, Aryl, Aryl-(C1-C8)- Alkyl, Heteroaryl, Heteroaryl-(C1-C8)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C8)-Alkyl, (C3-C10)-Cycloalkyl, (C3-C10)-Cycloalkyl-(C1-C8)-Alkyl, R32(O=)C-(C1-C8)-Alkyl, R32O(O)C-(C1-C8)-Alkyl, R30R31N(O)C-(C1-C8)-Alkyl, R33S(O)m-(C1-C8)-alkyl, R32O- (C1-C8)-Alkyl, R30R31N-(C1-C8)-Alkyl steht, R37 für (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkinyl, (C1-C10)-Haloalkyl, (C2-C8)- Haloalkenyl, (C2-C8)-Haloalkinyl, (C3-C10)-Cycloalkyl, (C3-C10)-Halocycloalkyl, (C4-C10)-Cycloalkenyl, (C4-C10)-Halocycloalkenyl, Aryl, Aryl-(C1-C8)-Alkyl, Heteroaryl, Heteroaryl-(C1-C8)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C8)-Alkyl, Heteroaryloxy-(C1-C8)-Alkyl, Aryloxy-(C1-C8)-Alkyl, Heterocyclyloxy-(C1-C8)-Alkyl, R32O-(C1-C8)-Alkyl, R30R31N-(C1-C8)-Alkyl, R32O(O)C-(C1-C8)-Alkyl, R30R31N(O)C- (C1-C8)-Alkyl, (C3-C10)-Cycloalkyl-(C1-C8)-Alkyl, R33S(O)m-(C1-C8)-alkyl, R32(O=)C- (C1-C8)-Alkyl steht und R38 für (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkinyl, Aryl, Aryl-(C1-C8)-Alkyl, Heteroaryl, Heteroaryl-(C1-C8)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C8)-Alkyl, (C3-C10)-Cycloalkyl, (C3-C10)-Cycloalkyl-(C1-C8)-Alkyl, R32(O=)C-(C1-C8)-Alkyl, R32O(O)C-(C1-C8)-Alkyl, R30R31N(O)C-(C1-C8)-Alkyl, R33S(O)m-(C1-C8)-alkyl, R32O- (C1-C8)-Alkyl, R30R31N-(C1-C8)-Alkyl steht. 2. Verwendung gemäß Anspruch 1, wobei in Formel (I) R1 für Wasserstoff, NR30R31, OR32, S(O)mR33, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)- Alkinyl, (C1-C6)-Haloalkyl, (C2-C6)-Haloalkenyl, (C2-C6)-Haloalkinyl, (C3-C6)- Cycloalkyl, (C3-C6)-Halocycloalkyl, (C4-C6)-Cycloalkenyl, (C4-C6)-Halocycloalkenyl, Aryl, Aryl-(C1-C6)-Alkyl, Heteroaryl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-Alkyl, R32O-(C1-C6)-Alkyl, R30R31N-(C1-C6)-Alkyl, R32O(O)C- (C1-C6)-Alkyl, R30R31N(O)C-(C1-C6)-Alkyl, (C3-C10)-Cycloalkyl-(C1-C6)-Alkyl, R33S(O)m-(C1-C6)-alkyl, R32(O=)C-(C1-C6)-Alkyl, C(=O)R32, C(=O)OR32 steht, m für 0, 1, 2 steht, R3 und R4 unabhängig voneinander für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C1-C10)- Haloalkyl, (C3-C6)-Cycloalkyl, (C3-C6)-Cycloalkyl-(C1-C6)-Alkyl, Aryl-(C1-C6)-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-Alkyl, R32O-(C1-C6)-Alkyl, R30R31N-(C1-C6)-Alkyl stehen, R5, R6 unabhängig voneinander für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C1-C6)- Haloalkyl, (C3-C6)-Cycloalkyl, Aryl-(C1-C6)-Alkyl, Aryl, Heteroaryl, Heteroaryl- (C1-C6)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-Alkyl, R32O-(C1-C6)-Alkyl, R30R31N- (C1-C6)-Alkyl, NR30R31, OR32, (C3-C6)-Cycloalkyl-(C1-C6)-Alkyl stehen, R3 und R5 mit den Kohlenstoffatomen, an die sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 5 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, R2 für Wasserstoff und eine der nachfolgenden Gruppen G-1 bis G-2 steht, wobei ein Pfeil für eine Bindung zum Pyrrolidinonring in der allgemeinen Formel (I) steht, R7 für Wasserstoff und eine der nachfolgenden Gruppen G-1 bis G-15 steht, wobei ein Pfeil für eine Bindung zum Pyrrolidinonring in der allgemeinen Formel (I) steht, mit der Maßgabe, dass R2 und R7 nicht gleichzeitig H sind und dass R7 für H steht, wenn R2 für eine der nachfolgenden Gruppen G-1 bis G-2 steht, und dass R2 für H steht, wenn R7 für eine der nachfolgenden Gruppen G-1 bis G-15 steht, ( R8, R9, R10, R15, R18, R19, R20 unabhängig voneinander für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)- Alkenyl, (C2-C6)-Alkinyl, Aryl-(C1-C6)-Alkyl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl- (C1-C6)-Alkyl, R32O-(C1-C6)-Alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-Alkyl, S(O)mR33, R32(O=)C-(C1-C6)-Alkyl, C(O=)R32, (C1-C6)-Alkyloxycarbonyl, Aryl-(C1-C6)- Alkyloxycarbonyl stehen, R8 und R9 mit den Stickstoffatomen, an die sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 5 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, R11, R12, R13, R14 unabhängig voneinander für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, (C1-C6)-Haloalkyl, (C3-C6)-Cycloalkyl, Aryl-(C1-C6)-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-Alkyl, R32O- (C1-C6)-Alkyl, R30R31N-(C1-C6)-Alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-Alkyl, C(=O)R32, C(=O)OR32, C(=O)NR30R31, R32O(O)C-(C1-C6)-Alkyl, R30R31N(O)C-(C1-C6)-Alkyl, OR32 stehen, R16, R17, R21, R22 unabhängig voneinander für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, (C1-C6)-Haloalkyl, (C3-C6)-Cycloalkyl, Aryl-(C1-C6)-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-Alkyl, R32O- (C1-C6)-Alkyl, R30R31N-(C1-C6)-Alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-Alkyl, C(=O)R32, C(=O)OR32, C(=O)NR30R31 stehen, R23, R24 unabhängig voneinander für Wasserstoff, (C1-C6)-Alkyl, (C1-C6)-Haloalkyl, (C3-C6)- Cycloalkyl, Aryl-(C1-C6)-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-Alkyl, R32O-(C1-C6)-Alkyl, R30R31N-(C1-C6)-Alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-Alkyl, C(O=)R32, (C1-C6)-Alkyloxycarbonyl, Aryl-(C1-C6)- Alkyloxycarbonyl stehen, R25, R28, R29 unabhängig voneinander für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)- Alkinyl, Aryl-(C1-C6)-Alkyl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl-(C1-C6)-Alkyl, R32O-(C1-C6)-Alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-Alkyl, R32(O=)C-(C1-C6)-Alkyl stehen, R26, R27 unabhängig voneinander für Wasserstoff, (C1-C6)-Alkyl, (C1-C6)-Haloalkyl, (C3-C6)- Cycloalkyl, (C3-C6)-Cycloalkyl-(C1-C6)-Alkyl, Aryl-(C1-C6)-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-Alkyl stehen, R30 und R31 unabhängig voneinander für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)- Alkinyl, (C1-C6)-Cyanoalkyl, (C1-C6)-Haloalkyl, (C2-C6)-Haloalkenyl, (C3-C6)- Haloalkinyl, (C3-C6)-Cycloalkyl, (C3-C6)-Halocycloalkyl, (C4-C6)-Cycloalkenyl, (C4-C6)-Halocycloalkenyl, (C1-C6)-Alkoxy-(C1-C6)-alkyl, (C1-C6)-Haloalkoxy-(C1-C6)- alkyl, (C1-C6)-Alkylthio-(C1-C6)-alkyl, (C1-C6)-Haloalkylthio-(C1-C6)-alkyl, (C1-C6)- Alkoxy-(C1-C6)-haloalkyl, Aryl, Aryl-(C1-C6)-alkyl, Heteroaryl, Heteroaryl-(C1-C6)- alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-alkyl, (C4-C6)-Cycloalkenyl-(C1-C6)-alkyl, COR32, SO2R33, Heterocyclyl, (C1-C6)-Alkoxycarbonyl, Bis-[(C1-C6)-alkyl]aminocarbonyl- (C1-C6)-alkyl, (C1-C6)-Alkyl-aminocarbonyl-(C1-C6)-alkyl, Aryl-(C1-C6)-alkyl- aminocarbonyl-(C1-C6)-alkyl, Aryl-(C1-C6)-alkoxycarbonyl, Heteroaryl-(C1-C6)- alkoxycarbonyl, (C2-C6)-Alkenyloxycarbonyl, (C2-C6)-Alkinyloxycarbonyl, Heterocyclyl-(C1-C6)-alkyl, (C1-C6)-Alkoxycarbonyl-(C1-C6)-alkyl, (C2-C6)- Alkenyloxycarbonyl-(C1-C6)-alkyl, (C2-C6)-Alkinyloxycarbonyl-(C1-C6)-alkyl, Aryl-(C1-C6)-alkoxycarbonyl-(C1-C6)-alkyl, Heteroaryl-(C1-C6)-alkoxycarbonyl- (C1-C6)-alkyl, Heterocyclyl-(C1-C6)-alkoxycarbonyl-(C1-C6)-alkyl stehen, oder R30 und R31 mit dem Stickstoffatom, an das sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 3 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, R32 für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, (C1-C6)-Cyanoalkyl, (C1-C6)-Haloalkyl, (C2-C6)-Haloalkenyl, (C3-C6)-Haloalkinyl, (C3-C6)-Cycloalkyl, (C3-C6)-Halocycloalkyl, (C4-C6)-Cycloalkenyl, (C4-C6)-Halocycloalkenyl, (C1-C6)- Alkoxy-(C1-C6)-alkyl, (C1-C6)-Haloalkoxy-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)- haloalkyl, (C1-C6)-Alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)- alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkoxy- (C1-C6)-alkoxy-(C1-C6)-alkyl, Aryl, Aryl-(C1-C6)-alkyl, Aryl-(C1-C6)-alkoxy-(C1-C6)- alkyl, Heteroaryl, Heteroaryl-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-alkyl, (C4-C6)- Cycloalkenyl-(C1-C6)-alkyl, Bis-[(C1-C6)-alkyl]aminocarbonyl-(C1-C6)-alkyl, (C1-C6)- Alkyl-aminocarbonyl-(C1-C6)-alkyl, Aryl-(C1-C6)-alkyl-aminocarbonyl-(C1-C6)-alkyl, Bis-[(C1-C6)-alkyl]amino-(C2-C6)-alkyl, (C1-C6)-Alkyl-amino-(C2-C6)-alkyl, Aryl-(C1- C6)-alkyl-amino-(C2-C6)-alkyl, R33(O)mS-(C1-C6)-alkyl, Hydroxycarbonyl-(C1-C6)-alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-alkyl, Tris-[(C1-C6)-Alkyl]silyl-(C1-C6)-alkyl, Bis- [(C1-C6)-Alkyl](aryl)silyl(C1-C6)-alkyl, [(C1-C6)-Alkyl]-bis-(aryl)silyl-(C1-C6)-alkyl, (C1-C6)-Alkylcarbonyloxy-(C1-C6)-alkyl, (C3-C6)-Cycloalkylcarbonyloxy-(C1-C6)-alkyl, Arylcarbonyloxy-(C1-C6)-alkyl, Heteroarylcarbonyloxy-(C1-C6)-alkyl, Heterocyclylcarbonyloxy-(C1-C6)-alkyl, Aryloxy-(C1-C6)-alkyl, Heteroaryloxy-(C1-C6)- alkyl, Heterocyclyloxy-(C1-C6)-alkyl, (C1-C6)-Alkoxycarbonyl, (C1-C6)- Alkoxycarbonyl-(C1-C6)-alkyl, (C2-C6)-Alkenyloxycarbonyl-(C1-C6)-alkyl, (C2-C6)-Alkinyloxycarbonyl-(C1-C6)-alkyl, Aryl-(C1-C6)-alkoxycarbonyl- (C1-C6)-alkyl, Heteroaryl-(C1-C6)-alkoxycarbonyl-(C1-C6)-alkyl, Heterocyclyl- (C1-C6)-alkoxycarbonyl-(C1-C6)-alkyl steht, R33 für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, (C1-C6)-Cyanoalkyl, (C1-C6)-Haloalkyl, (C2-C6)-Haloalkenyl, (C3-C6)-Haloalkinyl, (C3-C10)-Cycloalkyl, (C3-C10)-Halocycloalkyl, (C4-C6)-Cycloalkenyl, (C4-C6)-Halocycloalkenyl, (C1-C6)- Alkoxy-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)-haloalkyl, Aryl, Aryl-(C1-C6)-alkyl, Heteroaryl, Heteroaryl-(C1-C6)-alkyl, Heterocyclyl-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl- (C1-C6)-alkyl, (C4-C10)-Cycloalkenyl-(C1-C6)-alkyl, Bis-[(C1-C6)-alkyl]amino, (C1-C6)- Alkyl-amino, Aryl-(C1-C6)-amino, Aryl-(C1-C6)-alkyl-amino, Aryl-[(C1-C6)- alkyl]amino; Heteroaryl-(C1-C6)-amino, Heteroaryl-(C1-C6)-alkyl-amino, Heteroaryl- [(C1-C6)-alkyl]amino; Hetercyclyl-(C1-C6)-amino, Heterocyclyl-(C1-C6)-alkyl-amino, Heterocyclyl-[(C1-C6)-alkyl]amino; (C3-C6)-Cycloalkyl-amino, (C3-C6)-Cycloalkyl-[(C1- C6)-alkyl]amino; N-Azetidinyl, N-Pyrrolidinyl, N-Piperidinyl. N-Morpholinyl steht, R34 für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, Aryl-(C1-C6)-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-Alkyl, R32O-(C1-C6)- Alkyl, R30R31N-(C1-C6)-Alkyl, NR30R31, (C3-C6)-Cycloalkyl-(C1-C6)-Alkyl, S(O)mR33 steht, R35 für Wasserstoff, NR30R31, OR32, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, Aryl, Aryl-(C1-C6)-Alkyl, Heteroaryl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl, Heterocyclyl- (C1-C6)-Alkyl, R32O-(C1-C6)-Alkyl, (C3-C6)-Cycloalkyl, (C3-C6)-Cycloalkyl-(C1-C6)- Alkyl, S(O)mR33, R32(O=)C-(C1-C6)-Alkyl, R32O(O)C-(C1-C6)-Alkyl, R30R31N(O)C- (C1-C6)-Alkyl, R33S(O)m-(C1-C6)-alkyl, R32O-(C1-C6)-Alkyl, R30R31N-(C1-C6)-Alkyl steht, R36 für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, Aryl, Aryl-(C1-C6)- Alkyl, Heteroaryl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-Alkyl, (C3-C10)-Cycloalkyl, (C3-C6)-Cycloalkyl-(C1-C6)-Alkyl, R32(O=)C-(C1-C6)-Alkyl, R32O(O)C-(C1-C6)-Alkyl, R30R31N(O)C-(C1-C6)-Alkyl, R33S(O)m-(C1-C6)-alkyl, R32O- (C1-C6)-Alkyl, R30R31N-(C1-C6)-Alkyl steht, R37 für (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, (C1-C6)-Haloalkyl, (C2-C6)- Haloalkenyl, (C2-C6)-Haloalkinyl, (C3-C6)-Cycloalkyl, (C3-C6)-Halocycloalkyl, (C4-C6)- Cycloalkenyl, (C4-C6)-Halocycloalkenyl, Aryl, Aryl-(C1-C6)-Alkyl, Heteroaryl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-Alkyl, Heteroaryloxy- (C1-C6)-Alkyl, Aryloxy-(C1-C6)-Alkyl, Heterocyclyloxy-(C1-C6)-Alkyl, R32O-(C1-C6)- Alkyl, R30R31N-(C1-C6)-Alkyl, R32O(O)C-(C1-C6)-Alkyl, R30R31N(O)C-(C1-C6)-Alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-Alkyl, R33S(O)m-(C1-C6)-alkyl, R32(O=)C-(C1-C6)-Alkyl steht und R38 für (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkinyl, Aryl, Aryl-(C1-C8)-Alkyl, Heteroaryl, Heteroaryl-(C1-C8)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C8)-Alkyl, (C3-C10)-Cycloalkyl, (C3-C10)-Cycloalkyl-(C1-C8)-Alkyl, R32(O=)C-(C1-C8)-Alkyl, R32O(O)C-(C1-C8)-Alkyl, R30R31N(O)C-(C1-C8)-Alkyl, R33S(O)m-(C1-C8)-alkyl, R32O- (C1-C8)-Alkyl, R30R31N-(C1-C8)-Alkyl steht. 3. Verwendung gemäß Anspruch 1, wobei in Formel (I) R1 für Wasserstoff, NR30R31, OR32, S(O)mR33, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)- Alkinyl, (C1-C6)-Haloalkyl, (C2-C6)-Haloalkenyl, (C2-C6)-Haloalkinyl, (C3-C6)- Cycloalkyl, (C3-C6)-Halocycloalkyl, (C4-C6)-Cycloalkenyl, (C4-C6)-Halocycloalkenyl, Aryl, Aryl-(C1-C6)-Alkyl, Heteroaryl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-Alkyl, R32O-(C1-C6)-Alkyl, R30R31N-(C1-C6)-Alkyl, R32O(O)C- (C1-C6)-Alkyl, R30R31N(O)C-(C1-C6)-Alkyl, (C3-C10)-Cycloalkyl-(C1-C6)-Alkyl, R33S(O)m-(C1-C6)-alkyl, R32(O=)C-(C1-C6)-Alkyl, C(=O)R32, C(=O)OR32 steht, m für 0, 1, 2 steht, R3 und R4 unabhängig voneinander für Wasserstoff, Methyl, Ethyl, Prop-1-yl, 1-Methyleth-1-yl, Vinyl, 1-Methyleth-1-en-1.yl, prop-2-en-1-yl, Difluormethyl, Trifluormethyl, Cyclopropyl, Cyclobutyl, Cyclopropylmethyl, Cyclobutylmethyl, Cyclopentylmethyl, Cyclohexylmethyl, Phenyl, Benzyl, Methoxymethyl, Ethoxymethyl, Methoxyethyl, Ethoxyethyl stehen, R5, R6 unabhängig voneinander für Wasserstoff, Methyl, Ethyl, Prop-1-yl, 1-Methyleth-1-yl, Vinyl, prop-2-en-1-yl, Difluormethyl, Trifluormethyl, Cyclopropyl, Cyclobutyl, Cyclopropylmethyl, Cyclobutylmethyl, Cyclopentylmethyl, Cyclohexylmethyl, Phenyl, 4-Fluorphenyl, 3-Fluorphenyl, 2-Fluorphenyl, 4-Chlorphenyl, 3-Chlorphenyl, 2- Chlorphenyl, Benzyl, 4-Fluorbenzyl, 3-Fluorbenzyl, 2-Fluorbenzyl, Pyridin-2-ylmethyl, Pyridin-3-ylmethyl, Pyridin-4-ylmethyl, Methoxymethyl, Ethoxymethyl, Methoxyethyl, Ethoxyethyl, Heterocyclyl, Hydroxy, Methoxy, Ethoxy, Methylcarbonyloxy, Ethylcarbonyloxy, 1-Methyleth-1-ylcarbonyloxy, 1,1-Dimethyleth-1-ylcarbonyloxy stehen, R3 und R5 mit den Kohlenstoffatomen, an die sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 5 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, R2 für Wasserstoff und eine der nachfolgenden Gruppen G-1 bis G-2 steht, wobei ein Pfeil für eine Bindung zum Pyrrolidinonring in der allgemeinen Formel (I) steht, R7 für Wasserstoff und eine der nachfolgenden Gruppen G-1 bis G-15 steht, wobei ein Pfeil für eine Bindung zum Pyrrolidinonring in der allgemeinen Formel (I) steht, mit der Maßgabe, dass R2 und R7 nicht gleichzeitig H sind und dass R7 für H steht, wenn R2 für eine der nachfolgenden Gruppen G-1 bis G-2 steht, und dass R2 für H steht, wenn R7 für eine der nachfolgenden Gruppen G-1 bis G-15 steht,

R8, R9, R10, R15, R18, R19, R20 unabhängig voneinander für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)- Alkenyl, (C2-C6)-Alkinyl, Aryl-(C1-C6)-Alkyl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl- (C1-C6)-Alkyl, R32O-(C1-C6)-Alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-Alkyl, S(O)mR33, R32(O=)C-(C1-C6)-Alkyl, C(O=)R32, (C1-C6)-Alkyloxycarbonyl, Aryl-(C1-C6)- Alkyloxycarbonyl stehen, R8 und R9 mit den Stickstoffatomen, an die sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 5 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, R11, R12, R13, R14 unabhängig voneinander für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, (C1-C6)-Haloalkyl, (C3-C6)-Cycloalkyl, Aryl-(C1-C6)-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-Alkyl, R32O- (C1-C6)-Alkyl, R30R31N-(C1-C6)-Alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-Alkyl, C(=O)R32, C(=O)OR32, C(=O)NR30R31, R32O(O)C-(C1-C6)-Alkyl, R30R31N(O)C-(C1-C6)-Alkyl, OR32 stehen, R16, R17, R21, R22 unabhängig voneinander für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, (C1-C6)-Haloalkyl, (C3-C6)-Cycloalkyl, Aryl-(C1-C6)-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-Alkyl, R32O- (C1-C6)-Alkyl, R30R31N-(C1-C6)-Alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-Alkyl, C(=O)R32, C(=O)OR32, C(=O)NR30R31 stehen, R23, R24 unabhängig voneinander für Wasserstoff, (C1-C6)-Alkyl, (C1-C6)-Haloalkyl, (C3-C6)- Cycloalkyl, Aryl-(C1-C6)-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-Alkyl, R32O-(C1-C6)-Alkyl, R30R31N-(C1-C6)-Alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-Alkyl, C(O=)R32, (C1-C6)-Alkyloxycarbonyl, Aryl-(C1-C6)- Alkyloxycarbonyl stehen, R25, R28, R29 unabhängig voneinander für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)- Alkinyl, Aryl-(C1-C6)-Alkyl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl-(C1-C6)-Alkyl, R32O-(C1-C6)-Alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-Alkyl, R32(O=)C-(C1-C6)-Alkyl stehen, R26, R27 unabhängig voneinander für Wasserstoff, (C1-C6)-Alkyl, (C1-C6)-Haloalkyl, (C3-C6)- Cycloalkyl, (C3-C6)-Cycloalkyl-(C1-C6)-Alkyl, Aryl-(C1-C6)-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-Alkyl stehen, R30 und R31 unabhängig voneinander für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)- Alkinyl, (C1-C6)-Cyanoalkyl, (C1-C6)-Haloalkyl, (C2-C6)-Haloalkenyl, (C3-C6)- Haloalkinyl, (C3-C6)-Cycloalkyl, (C3-C6)-Halocycloalkyl, (C4-C6)-Cycloalkenyl, (C4-C6)-Halocycloalkenyl, (C1-C6)-Alkoxy-(C1-C6)-alkyl, (C1-C6)-Haloalkoxy-(C1-C6)- alkyl, (C1-C6)-Alkylthio-(C1-C6)-alkyl, (C1-C6)-Haloalkylthio-(C1-C6)-alkyl, (C1-C6)- Alkoxy-(C1-C6)-haloalkyl, Aryl, Aryl-(C1-C6)-alkyl, Heteroaryl, Heteroaryl-(C1-C6)- alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-alkyl, (C4-C6)-Cycloalkenyl-(C1-C6)-alkyl, COR32, SO2R33, Heterocyclyl, (C1-C6)-Alkoxycarbonyl, Bis-[(C1-C6)-alkyl]aminocarbonyl- (C1-C6)-alkyl, (C1-C6)-Alkyl-aminocarbonyl-(C1-C6)-alkyl, Aryl-(C1-C6)-alkyl- aminocarbonyl-(C1-C6)-alkyl, Aryl-(C1-C6)-alkoxycarbonyl, Heteroaryl-(C1-C6)- alkoxycarbonyl, (C2-C6)-Alkenyloxycarbonyl, (C2-C6)-Alkinyloxycarbonyl, Heterocyclyl-(C1-C6)-alkyl, (C1-C6)-Alkoxycarbonyl-(C1-C6)-alkyl, (C2-C6)- Alkenyloxycarbonyl-(C1-C6)-alkyl, (C2-C6)-Alkinyloxycarbonyl-(C1-C6)-alkyl, Aryl-(C1-C6)-alkoxycarbonyl-(C1-C6)-alkyl, Heteroaryl-(C1-C6)-alkoxycarbonyl- (C1-C6)-alkyl, Heterocyclyl-(C1-C6)-alkoxycarbonyl-(C1-C6)-alkyl stehen, oder R30 und R31 mit dem Stickstoffatom, an das sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 3 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, R32 für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, (C1-C6)-Cyanoalkyl, (C1-C6)-Haloalkyl, (C2-C6)-Haloalkenyl, (C3-C6)-Haloalkinyl, (C3-C6)-Cycloalkyl, (C3-C6)-Halocycloalkyl, (C4-C6)-Cycloalkenyl, (C4-C6)-Halocycloalkenyl, (C1-C6)- Alkoxy-(C1-C6)-alkyl, (C1-C6)-Haloalkoxy-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)- haloalkyl, (C1-C6)-Alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)- alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkoxy- (C1-C6)-alkoxy-(C1-C6)-alkyl, Aryl, Aryl-(C1-C6)-alkyl, Aryl-(C1-C6)-alkoxy-(C1-C6)- alkyl, Heteroaryl, Heteroaryl-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-alkyl, (C4-C6)- Cycloalkenyl-(C1-C6)-alkyl, Bis-[(C1-C6)-alkyl]aminocarbonyl-(C1-C6)-alkyl, (C1-C6)- Alkyl-aminocarbonyl-(C1-C6)-alkyl, Aryl-(C1-C6)-alkyl-aminocarbonyl-(C1-C6)-alkyl, Bis-[(C1-C6)-alkyl]amino-(C2-C6)-alkyl, (C1-C6)-Alkyl-amino-(C2-C6)-alkyl, Aryl-(C1- C6)-alkyl-amino-(C2-C6)-alkyl, R33(O)mS-(C1-C6)-alkyl, Hydroxycarbonyl-(C1-C6)-alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-alkyl, Tris-[(C1-C6)-Alkyl]silyl-(C1-C6)-alkyl, Bis- [(C1-C6)-Alkyl](aryl)silyl(C1-C6)-alkyl, [(C1-C6)-Alkyl]-bis-(aryl)silyl-(C1-C6)-alkyl, (C1-C6)-Alkylcarbonyloxy-(C1-C6)-alkyl, (C3-C6)-Cycloalkylcarbonyloxy-(C1-C6)-alkyl, Arylcarbonyloxy-(C1-C6)-alkyl, Heteroarylcarbonyloxy-(C1-C6)-alkyl, Heterocyclylcarbonyloxy-(C1-C6)-alkyl, Aryloxy-(C1-C6)-alkyl, Heteroaryloxy-(C1-C6)- alkyl, Heterocyclyloxy-(C1-C6)-alkyl, (C1-C6)-Alkoxycarbonyl, (C1-C6)- Alkoxycarbonyl-(C1-C6)-alkyl, (C2-C6)-Alkenyloxycarbonyl-(C1-C6)-alkyl, (C2-C6)-Alkinyloxycarbonyl-(C1-C6)-alkyl, Aryl-(C1-C6)-alkoxycarbonyl- (C1-C6)-alkyl, Heteroaryl-(C1-C6)-alkoxycarbonyl-(C1-C6)-alkyl, Heterocyclyl- (C1-C6)-alkoxycarbonyl-(C1-C6)-alkyl steht, R33 für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, (C1-C6)-Cyanoalkyl, (C1-C6)-Haloalkyl, (C2-C6)-Haloalkenyl, (C3-C6)-Haloalkinyl, (C3-C10)-Cycloalkyl, (C3-C10)-Halocycloalkyl, (C4-C6)-Cycloalkenyl, (C4-C6)-Halocycloalkenyl, (C1-C6)- Alkoxy-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)-haloalkyl, Aryl, Aryl-(C1-C6)-alkyl, Heteroaryl, Heteroaryl-(C1-C6)-alkyl, Heterocyclyl-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl- (C1-C6)-alkyl, (C4-C10)-Cycloalkenyl-(C1-C6)-alkyl, Bis-[(C1-C6)-alkyl]amino, (C1-C6)- Alkyl-amino, Aryl-(C1-C6)-amino, Aryl-(C1-C6)-alkyl-amino, Aryl-[(C1-C6)- alkyl]amino; Heteroaryl-(C1-C6)-amino, Heteroaryl-(C1-C6)-alkyl-amino, Heteroaryl- [(C1-C6)-alkyl]amino; Hetercyclyl-(C1-C6)-amino, Heterocyclyl-(C1-C6)-alkyl-amino, Heterocyclyl-[(C1-C6)-alkyl]amino; (C3-C6)-Cycloalkyl-amino, (C3-C6)-Cycloalkyl-[(C1- C6)-alkyl]amino; N-Azetidinyl, N-Pyrrolidinyl, N-Piperidinyl. N-Morpholinyl steht, R34 für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, Aryl-(C1-C6)-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-Alkyl, R32O-(C1-C6)- Alkyl, R30R31N-(C1-C6)-Alkyl, NR30R31, (C3-C6)-Cycloalkyl-(C1-C6)-Alkyl, S(O)mR33 steht, R35 für Wasserstoff, NR30R31, OR32, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, Aryl, Aryl-(C1-C6)-Alkyl, Heteroaryl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl, Heterocyclyl- (C1-C6)-Alkyl, R32O-(C1-C6)-Alkyl, (C3-C6)-Cycloalkyl, (C3-C6)-Cycloalkyl-(C1-C6)- Alkyl, S(O)mR33, R32(O=)C-(C1-C6)-Alkyl, R32O(O)C-(C1-C6)-Alkyl, R30R31N(O)C- (C1-C6)-Alkyl, R33S(O)m-(C1-C6)-alkyl, R32O-(C1-C6)-Alkyl, R30R31N-(C1-C6)-Alkyl steht, R36 für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, Aryl, Aryl-(C1-C6)- Alkyl, Heteroaryl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-Alkyl, (C3-C10)-Cycloalkyl, (C3-C6)-Cycloalkyl-(C1-C6)-Alkyl, R32(O=)C-(C1-C6)-Alkyl, R32O(O)C-(C1-C6)-Alkyl, R30R31N(O)C-(C1-C6)-Alkyl, R33S(O)m-(C1-C6)-alkyl, R32O- (C1-C6)-Alkyl, R30R31N-(C1-C6)-Alkyl steht, R37 für (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, (C1-C6)-Haloalkyl, (C2-C6)- Haloalkenyl, (C2-C6)-Haloalkinyl, (C3-C6)-Cycloalkyl, (C3-C6)-Halocycloalkyl, (C4-C6)- Cycloalkenyl, (C4-C6)-Halocycloalkenyl, Aryl, Aryl-(C1-C6)-Alkyl, Heteroaryl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-Alkyl, Heteroaryloxy- (C1-C6)-Alkyl, Aryloxy-(C1-C6)-Alkyl, Heterocyclyloxy-(C1-C6)-Alkyl, R32O-(C1-C6)- Alkyl, R30R31N-(C1-C6)-Alkyl, R32O(O)C-(C1-C6)-Alkyl, R30R31N(O)C-(C1-C6)-Alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-Alkyl, R33S(O)m-(C1-C6)-alkyl, R32(O=)C-(C1-C6)-Alkyl steht und R38 für (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkinyl, Aryl, Aryl-(C1-C8)-Alkyl, Heteroaryl, Heteroaryl-(C1-C8)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C8)-Alkyl, (C3-C10)-Cycloalkyl, (C3-C10)-Cycloalkyl-(C1-C8)-Alkyl, R32(O=)C-(C1-C8)-Alkyl, R32O(O)C-(C1-C8)-Alkyl, R30R31N(O)C-(C1-C8)-Alkyl, R33S(O)m-(C1-C8)-alkyl, R32O- (C1-C8)-Alkyl, R30R31N-(C1-C8)-Alkyl steht.

4. Behandlung von Pflanzen, umfassend die Applikation einer zur Steigerung der Widerstandsfähigkeit von Pflanzen gegenüber abiotischen Stressfaktoren wirksamen, nicht- toxischen Menge einer oder mehrerer der Verbindungen der Formel (I), oder jeweils deren Salze gemäß einem der Ansprüche 1 bis 3. 5. Behandlung gemäß Anspruch 4, wobei die abiotischen Stressbedingungen einer oder mehrerer Bedingungen ausgewählt aus der Gruppe bestehend aus Dürre, Kältestress, Hitzestress, Trockenstress, osmotischem Stress, Staunässe, erhöhtem Bodensalzgehalt, erhöhtem Ausgesetztsein an Mineralien, Ozonbedingungen, Starklichtbedingungen, beschränkter Verfügbarkeit von Stickstoffnährstoffen und beschränkter Verfügbarkeit von Phosphornährstoffen entsprechen. 6. Verwendung einer oder mehrerer Verbindungen der Formel (I), oder jeweils deren Salze gemäß einem der Ansprüche 1 bis 3 in der Sprühapplikation auf Pflanzen und Pflanzenteilen in Kombinationen mit einem oder mehrer Wirkstoffen ausgewählt aud der Gruppe der Insektizide, Lockstoffe, Akarizide, Fungizide, Nematizide, Herbizide, wachstumsregulatorische Stoffe, Safener, die Pflanzenreife beeinflussende Stoffe und Bakterizide. 7. Verwendung einer oder mehrerer Verbindungen der Formel (I), oder jeweils deren Salze gemäß einem der Ansprüche 1 bis 3 in der Sprühapplikation auf Pflanzen und Pflanzenteilen in Kombinationen mit Düngemitteln. 8. Verwendung einer oder mehrerer Verbindungen der Formel (I), oder jeweils deren Salze gemäß einem der Ansprüche 1 bis 3 zur Applikation auf gentechnisch veränderten Sorten, deren Saatgut, oder auf Anbauflächen auf denen diese Sorten wachsen. 9. Verwendung von Sprühlösungen, die eine oder mehrere der Verbindungen der Formel (I), oder jeweils deren Salze gemäß einem der Ansprüche 1 bis 3 enthalten, zur Steigerung der Widerstandsfähigkeit von Pflanzen gegenüber abiotischen Stressfaktoren. 10. Verfahren zur Erhöhung der Stresstoleranz bei Pflanzen ausgewählt aus der Gruppe der Nutzpflanzen, Zierpflanzen, Rasenarten, oder Bäumen, dadurch gekennzeichnet, dass die Applikation einer ausreichenden, nicht-toxischen Menge einer oder mehrere Verbindungen der Formel (I), oder jeweils deren Salze gemäß einem der Ansprüche 1 bis 3 auf die Fläche, wo die entsprechende Wirkung gewünscht wird, umfassend die Anwendung auf die Pflanzen, deren Saatgut oder auf die Fläche auf der die Pflanzen wachsen, erfolgt.

11. Substituierte N-Pyrrolidinone der allgemeinen Formel (I) oder deren Salze, worin R1 für (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkinyl, (C1-C10)-Haloalkyl, (C3-C10)- Cycloalkyl, (C3-C10)-Halocycloalkyl, (C4-C10)-Cycloalkenyl, Aryl, Aryl-(C1-C8)-Alkyl, Heteroaryl, Heteroaryl-(C1-C8)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C8)-Alkyl, R32O- (C1-C8)-Alkyl, (C3-C10)-Cycloalkyl-(C1-C8)-Alkyl steht, R2 für Wasserstoff steht, R7 für eine der nachfolgenden Gruppen G-4 bis G-6 steht, wobei ein Pfeil für eine Bindung zum Pyrrolidinonring in der allgemeinen Formel (I) steht, R3, R4 unabhängig voneinander für Wasserstoff, (C1-C8)-Alkyl, (C1-C10)-Haloalkyl, (C3-C10)- Cycloalkyl, (C3-C10)-Cycloalkyl-(C1-C8)-Alkyl, OR32 stehen, R5, R6 unabhängig voneinander für Wasserstoff, (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C1-C10)- Haloalkyl, (C3-C10)-Cycloalkyl, Aryl-(C1-C8)-Alkyl, Aryl, Heteroaryl, Heteroaryl- (C1-C8)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C8)-Alkyl, R32O-(C1-C8)-Alkyl, R30R31N- (C1-C8)-Alkyl, NR30R31, OR32, (C3-C10)-Cycloalkyl-(C1-C8)-Alkyl stehen, R8, R9, R10 unabhängig voneinander für Wasserstoff, (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)- Alkinyl, Aryl-(C1-C8)-Alkyl, Heteroaryl-(C1-C8)-Alkyl, C(O=)R32, (C1-C8)- Alkyloxycarbonyl, Aryl-(C1-C8)-Alkyloxycarbonyl stehen, R11, R12 unabhängig voneinander für Wasserstoff, (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)- Alkinyl, (C1-C10)-Haloalkyl, (C3-C10)-Cycloalkyl, Aryl-(C1-C8)-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C1-C8)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C8)-Alkyl, R32O-(C1-C8)- Alkyl, R30R31N-(C1-C8)-Alkyl, (C3-C10)-Cycloalkyl-(C1-C8)-Alkyl, C(=O)R32, C(=O)OR32, C(=O)NR30R31, R32O(O)C-(C1-C8)-Alkyl, R30R31N(O)C-(C1-C8)-Alkyl, OR32 stehen, R30 und R31 unabhängig voneinander für Wasserstoff, (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)- Alkinyl, (C1-C8)-Cyanoalkyl, (C1-C10)-Haloalkyl, (C2-C8)-Haloalkenyl, (C3-C8)- Haloalkinyl, (C3-C10)-Cycloalkyl, (C3-C10)-Halocycloalkyl, (C4-C10)-Cycloalkenyl, (C4-C10)-Halocycloalkenyl, (C1-C8)-Alkoxy-(C1-C8)-alkyl, (C1-C8)-Haloalkoxy-(C1-C8)- alkyl, (C1-C8)-Alkylthio-(C1-C8)-alkyl, (C1-C8)-Haloalkylthio-(C1-C8)-alkyl, (C1-C8)- Alkoxy-(C1-C8)-haloalkyl, Aryl, Aryl-(C1-C8)-alkyl, Heteroaryl, Heteroaryl-(C1-C8)- alkyl, (C3-C8)-Cycloalkyl-(C1-C8)-alkyl, (C4-C10)-Cycloalkenyl-(C1-C8)-alkyl, COR32, SO2R33, Heterocyclyl, (C1-C8)-Alkoxycarbonyl, Bis-[(C1-C8)-alkyl]aminocarbonyl- (C1-C8)-alkyl, (C1-C8)-Alkyl-aminocarbonyl-(C1-C8)-alkyl, Aryl-(C1-C8)-alkyl- aminocarbonyl-(C1-C8)-alkyl, Aryl-(C1-C8)-alkoxycarbonyl, Heteroaryl-(C1-C8)- alkoxycarbonyl, (C2-C8)-Alkenyloxycarbonyl, (C2-C8)-Alkinyloxycarbonyl, (C1-C8)- Alkoxycarbonyl-(C1-C8)-alkyl, (C2-C8)-Alkenyloxycarbonyl-(C1-C8)-alkyl, (C2-C8)-Alkinyloxycarbonyl-(C1-C8)-alkyl, Aryl-(C1-C8)-alkoxycarbonyl- (C1-C8)-alkyl, Heteroaryl-(C1-C8)-alkoxycarbonyl-(C1-C8)-alkyl, Heterocyclyl- (C1-C8)-alkoxycarbonyl-(C1-C8)-alkyl, Heterocyclyl-(C1-C8)-alkyl stehen, oder R30 und R31 mit dem Stickstoffatom, an das sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 3 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, R32 für Wasserstoff, (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkinyl, (C1-C8)-Cyanoalkyl, (C1-C10)-Haloalkyl, (C2-C8)-Haloalkenyl, (C3-C8)-Haloalkinyl, (C3-C10)-Cycloalkyl, (C3-C10)-Halocycloalkyl, (C4-C10)-Cycloalkenyl, (C4-C10)-Halocycloalkenyl, (C1-C8)- Alkoxy-(C1-C8)-alkyl, (C1-C8)-Haloalkoxy-(C1-C8)-alkyl, (C1-C8)-Alkoxy-(C1-C8)- haloalkyl, (C1-C8)-Alkoxy-(C1-C8)-alkoxy-(C1-C8)-alkyl, (C1-C8)-Alkoxy-(C1-C8)- alkoxy-(C1-C8)-alkoxy-(C1-C8)-alkyl, (C1-C8)-Alkoxy-(C1-C8)-alkoxy-(C1-C8)-alkoxy- (C1-C8)-alkoxy-(C1-C8)-alkyl, Aryl, Aryl-(C1-C8)-alkyl, Aryl-(C1-C8)-alkoxy-(C1-C8)- alkyl, Heteroaryl, Heteroaryl-(C1-C8)-alkyl, (C3-C8)-Cycloalkyl-(C1-C8)-alkyl, (C4-C10)- Cycloalkenyl-(C1-C8)-alkyl, Bis-[(C1-C8)-alkyl]aminocarbonyl-(C1-C8)-alkyl, (C1-C8)- Alkyl-aminocarbonyl-(C1-C8)-alkyl, Aryl-(C1-C8)-alkyl-aminocarbonyl-(C1-C8)-alkyl, Bis-[(C1-C8)-alkyl]amino-(C2-C6)-alkyl, (C1-C8)-Alkyl-amino-(C2-C6)-alkyl, Aryl-(C1- C8)-alkyl-amino-(C2-C6)-alkyl, R33(O)mS-(C1-C8)-alkyl, Hydroxycarbonyl-(C1-C8)-alkyl, Heterocyclyl, Heterocyclyl-(C1-C8)-alkyl, Tris-[(C1-C8)-Alkyl]silyl-(C1-C8)-alkyl, Bis- [(C1-C8)-Alkyl](aryl)silyl(C1-C8)-alkyl, [(C1-C8)-Alkyl]-bis-(aryl)silyl-(C1-C8)-alkyl, (C1-C8)-Alkylcarbonyloxy-(C1-C8)-alkyl, (C3-C8)-Cycloalkylcarbonyloxy-(C1-C8)-alkyl, Arylcarbonyloxy-(C1-C8)-alkyl, Heteroarylcarbonyloxy-(C1-C8)-alkyl, Heterocyclylcarbonyloxy-(C1-C8)-alkyl, Aryloxy-(C1-C8)-alkyl, Heteroaryloxy-(C1-C8)- alkyl, Heterocyclyloxy-(C1-C8)-alkyl, (C1-C8)-Alkoxycarbonyl, (C1-C8)- Alkoxycarbonyl-(C1-C8)-alkyl, (C2-C8)-Alkenyloxycarbonyl-(C1-C8)-alkyl, (C2-C8)-Alkinyloxycarbonyl-(C1-C8)-alkyl, Aryl-(C1-C8)-alkoxycarbonyl- (C1-C8)-alkyl, Heteroaryl-(C1-C8)-alkoxycarbonyl-(C1-C8)-alkyl, Heterocyclyl- (C1-C8)-alkoxycarbonyl-(C1-C8)-alkyl steht, R33 für Wasserstoff, (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkinyl, (C1-C8)-Cyanoalkyl, (C1-C10)-Haloalkyl, (C2-C8)-Haloalkenyl, (C3-C8)-Haloalkinyl, (C3-C10)-Cycloalkyl, (C3-C10)-Halocycloalkyl, (C4-C10)-Cycloalkenyl, (C4-C10)-Halocycloalkenyl, (C1-C8)- Alkoxy-(C1-C8)-alkyl, (C1-C8)-Alkoxy-(C1-C8)-haloalkyl, Aryl, Aryl-(C1-C8)-alkyl, Heteroaryl, Heteroaryl-(C1-C8)-alkyl, Heterocyclyl-(C1-C8)-alkyl, (C3-C8)-Cycloalkyl- (C1-C8)-alkyl, (C4-C10)-Cycloalkenyl-(C1-C8)-alkyl, Bis-[(C1-C8)-alkyl]amino, (C1-C8)- Alkyl-amino, Aryl-(C1-C8)-amino, Aryl-(C1-C6)-alkyl-amino, Aryl-[(C1-C8)- alkyl]amino; Heteroaryl-(C1-C8)-amino, Heteroaryl-(C1-C6)-alkyl-amino, Heteroaryl- [(C1-C8)-alkyl]amino; Hetercyclyl-(C1-C8)-amino, Heterocyclyl-(C1-C6)-alkyl-amino, Heterocyclyl-[(C1-C8)-alkyl]amino; (C3-C8)-Cycloalkyl-amino, (C3-C8)-Cycloalkyl-[(C1- C8)-alkyl]amino; N-Azetidinyl, N-Pyrrolidinyl, N-Piperidinyl. N-Morpholinyl steht, R37 für Phenyl, 2-Fluorphenyl, 4-Fluorphenyl, 4-Brom-3-methylphenyl, 2-Chlorphenyl, 4- Chlorphenyl, 4-Acetylphenyl, 5-Chlor-2-methylphenyl, 2-Chlor-5-methylphenyl, 6- Chlorpyridin-3-yl, 2,5-Dimethylphenyl, 2,5-Difluorphenyl, 2,5-Dichlorphenyl, 6- Methylpyridin-2-yl, Pyridin-2-yl, 2,3-Dichlorphenyl, 2,6-Difluorphenyl, 2- Methylphenyl, 2,6-Dichlorphenyl, 2-Chlorpyridin-4-yl, Pyridazin-4-yl, 2- (Trifluormethyl)phenyl, 2-Cyanophenyl, 2-Bromphenyl, 2-Iodphenyl, 5-Fluor-2- methylphenyl, 5-Brom-2-methylphenyl, Pyridin-3-yl, 2-Chlorpyridin-3-yl, 2- Fluorpyridin-4-yl, 2-Fluorpyridin-3-yl steht und m für 0, 1, 2 steht. 12. Substituierte N-Pyrrolidinone der allgemeinen Formel (I) gemäß Anspruch 11 oder deren Salze, worin R1 für (C1-C7)-Alkyl, (C2-C7)-Alkenyl, (C2-C7)-Alkinyl, (C1-C10)-Haloalkyl, (C3-C10)- Cycloalkyl, (C3-C7)-Halocycloalkyl, (C4-C7)-Cycloalkenyl, Aryl, Aryl-(C1-C7)-Alkyl, Heteroaryl, Heteroaryl-(C1-C7)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C7)-Alkyl, R32O- (C1-C7)-Alkyl, (C3-C10)-Cycloalkyl-(C1-C7)-Alkyl steht, R2 für Wasserstoff steht, R7 für eine der nachfolgenden Gruppen G-4 bis G-6 steht, wobei ein Pfeil für eine Bindung zum Pyrrolidinonring in der allgemeinen Formel (I) steht, R3, R4 unabhängig voneinander für Wasserstoff, (C1-C7)-Alkyl, (C1-C7)-Haloalkyl, (C3-C7)- Cycloalkyl, (C3-C7)-Cycloalkyl-(C1-C7)-Alkyl, OR32 stehen, R5, R6 unabhängig voneinander für Wasserstoff, (C1-C7)-Alkyl, (C2-C7)-Alkenyl, (C1-C7)- Haloalkyl, (C3-C7)-Cycloalkyl, Aryl-(C1-C7)-Alkyl, Aryl, Heteroaryl, Heteroaryl- (C1-C7)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C7)-Alkyl, R32O-(C1-C7)-Alkyl, R30R31N- (C1-C7)-Alkyl, NR30R31, OR32, (C3-C7)-Cycloalkyl-(C1-C7)-Alkyl stehen, R8, R9, R10 unabhängig voneinander für Wasserstoff, (C1-C7)-Alkyl, (C2-C7)-Alkenyl, (C2-C7)- Alkinyl, Aryl-(C1-C7)-Alkyl, Heteroaryl-(C1-C7)-Alkyl, C(O=)R32, (C1-C7)- Alkyloxycarbonyl, Aryl-(C1-C7)-Alkyloxycarbonyl stehen, R11, R12 unabhängig voneinander für Wasserstoff, (C1-C7)-Alkyl, (C2-C7)-Alkenyl, (C2-C7)- Alkinyl, (C1-C7)-Haloalkyl, (C3-C7)-Cycloalkyl, Aryl-(C1-C7)-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C1-C7)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C7)-Alkyl, R32O-(C1-C7)- Alkyl, R30R31N-(C1-C7)-Alkyl, (C3-C7)-Cycloalkyl-(C1-C7)-Alkyl, C(=O)R32, C(=O)OR32, C(=O)NR30R31, R32O(O)C-(C1-C7)-Alkyl, R30R31N(O)C-(C1-C7)-Alkyl, OR32 stehen, R30 und R31 unabhängig voneinander für Wasserstoff, (C1-C7)-Alkyl, (C2-C7)-Alkenyl, (C2-C7)- Alkinyl, (C1-C7)-Cyanoalkyl, (C1-C7)-Haloalkyl, (C2-C7)-Haloalkenyl, (C3-C7)- Haloalkinyl, (C3-C7)-Cycloalkyl, (C3-C7)-Halocycloalkyl, (C4-C7)-Cycloalkenyl, (C4-C7)-Halocycloalkenyl, (C1-C7)-Alkoxy-(C1-C7)-alkyl, (C1-C7)-Haloalkoxy-(C1-C7)- alkyl, (C1-C7)-Alkylthio-(C1-C7)-alkyl, (C1-C7)-Haloalkylthio-(C1-C7)-alkyl, (C1-C7)- Alkoxy-(C1-C7)-haloalkyl, Aryl, Aryl-(C1-C7)-alkyl, Heteroaryl, Heteroaryl-(C1-C7)- alkyl, (C3-C7)-Cycloalkyl-(C1-C7)-alkyl, (C4-C7)-Cycloalkenyl-(C1-C7)-alkyl, COR32, SO2R33, Heterocyclyl, (C1-C7)-Alkoxycarbonyl, Bis-[(C1-C7)-alkyl]aminocarbonyl- (C1-C7)-alkyl, (C1-C7)-Alkyl-aminocarbonyl-(C1-C7)-alkyl, Aryl-(C1-C7)-alkyl- aminocarbonyl-(C1-C7)-alkyl, Aryl-(C1-C7)-alkoxycarbonyl, Heteroaryl-(C1-C7)- alkoxycarbonyl, (C2-C7)-Alkenyloxycarbonyl, (C2-C7)-Alkinyloxycarbonyl, (C1-C7)- Alkoxycarbonyl-(C1-C7)-alkyl, (C2-C7)-Alkenyloxycarbonyl-(C1-C7)-alkyl, (C2-C7)-Alkinyloxycarbonyl-(C1-C7)-alkyl, Aryl-(C1-C7)-alkoxycarbonyl- (C1-C7)-alkyl, Heteroaryl-(C1-C7)-alkoxycarbonyl-(C1-C7)-alkyl, Heterocyclyl- (C1-C7)-alkoxycarbonyl-(C1-C7)-alkyl, Heterocyclyl-(C1-C7)-alkyl stehen, oder R30 und R31 mit dem Stickstoffatom, an das sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 3 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, R32 für Wasserstoff, (C1-C7)-Alkyl, (C2-C7)-Alkenyl, (C2-C7)-Alkinyl, (C1-C7)-Cyanoalkyl, (C1-C7)-Haloalkyl, (C2-C7)-Haloalkenyl, (C3-C7)-Haloalkinyl, (C3-C7)-Cycloalkyl, (C3-C10)-Halocycloalkyl, (C4-C7)-Cycloalkenyl, (C4-C7)-Halocycloalkenyl, (C1-C7)- Alkoxy-(C1-C7)-alkyl, (C1-C7)-Haloalkoxy-(C1-C7)-alkyl, (C1-C7)-Alkoxy-(C1-C7)- haloalkyl, (C1-C7)-Alkoxy-(C1-C7)-alkoxy-(C1-C7)-alkyl, (C1-C7)-Alkoxy-(C1-C7)- alkoxy-(C1-C7)-alkoxy-(C1-C7)-alkyl, (C1-C7)-Alkoxy-(C1-C7)-alkoxy-(C1-C7)-alkoxy- (C1-C7)-alkoxy-(C1-C7)-alkyl, Aryl, Aryl-(C1-C7)-alkyl, Aryl-(C1-C7)-alkoxy-(C1-C7)- alkyl, Heteroaryl, Heteroaryl-(C1-C7)-alkyl, (C3-C7)-Cycloalkyl-(C1-C7)-alkyl, (C4-C7)- Cycloalkenyl-(C1-C7)-alkyl, Bis-[(C1-C7)-alkyl]aminocarbonyl-(C1-C7)-alkyl, (C1-C7)- Alkyl-aminocarbonyl-(C1-C7)-alkyl, Aryl-(C1-C7)-alkyl-aminocarbonyl-(C1-C7)-alkyl, Bis-[(C1-C7)-alkyl]amino-(C2-C6)-alkyl, (C1-C7)-Alkyl-amino-(C2-C6)-alkyl, Aryl-(C1- C7)-alkyl-amino-(C2-C6)-alkyl, R33(O)mS-(C1-C7)-alkyl, Hydroxycarbonyl-(C1-C7)-alkyl, Heterocyclyl, Heterocyclyl-(C1-C7)-alkyl, Tris-[(C1-C7)-Alkyl]silyl-(C1-C7)-alkyl, Bis- [(C1-C7)-Alkyl](aryl)silyl(C1-C7)-alkyl, [(C1-C7)-Alkyl]-bis-(aryl)silyl-(C1-C7)-alkyl, (C1-C7)-Alkylcarbonyloxy-(C1-C7)-alkyl, (C3-C7)-Cycloalkylcarbonyloxy-(C1-C7)-alkyl, Arylcarbonyloxy-(C1-C7)-alkyl, Heteroarylcarbonyloxy-(C1-C7)-alkyl, Heterocyclylcarbonyloxy-(C1-C7)-alkyl, Aryloxy-(C1-C7)-alkyl, Heteroaryloxy-(C1-C7)- alkyl, Heterocyclyloxy-(C1-C7)-alkyl, (C1-C7)-Alkoxycarbonyl, (C1-C7)- Alkoxycarbonyl-(C1-C7)-alkyl, (C2-C7)-Alkenyloxycarbonyl-(C1-C7)-alkyl, (C2-C7)-Alkinyloxycarbonyl-(C1-C7)-alkyl, Aryl-(C1-C7)-alkoxycarbonyl- (C1-C7)-alkyl, Heteroaryl-(C1-C7)-alkoxycarbonyl-(C1-C7)-alkyl, Heterocyclyl- (C1-C7)-alkoxycarbonyl-(C1-C7)-alkyl steht, R33 für Wasserstoff, (C1-C7)-Alkyl, (C2-C7)-Alkenyl, (C2-C7)-Alkinyl, (C1-C7)-Cyanoalkyl, (C1-C7)-Haloalkyl, (C2-C7)-Haloalkenyl, (C3-C7)-Haloalkinyl, (C3-C7)-Cycloalkyl, (C3-C7)-Halocycloalkyl, (C4-C7)-Cycloalkenyl, (C4-C7)-Halocycloalkenyl, (C1-C7)- Alkoxy-(C1-C7)-alkyl, (C1-C7)-Alkoxy-(C1-C7)-haloalkyl, Aryl, Aryl-(C1-C7)-alkyl, Heteroaryl, Heteroaryl-(C1-C7)-alkyl, Heterocyclyl-(C1-C7)-alkyl, (C3-C7)-Cycloalkyl- (C1-C7)-alkyl, (C4-C10)-Cycloalkenyl-(C1-C7)-alkyl, Bis-[(C1-C7)-alkyl]amino, (C1-C7)- Alkyl-amino, Aryl-(C1-C7)-amino, Aryl-(C1-C6)-alkyl-amino, Aryl-[(C1-C7)- alkyl]amino; Heteroaryl-(C1-C7)-amino, Heteroaryl-(C1-C6)-alkyl-amino, Heteroaryl- [(C1-C7)-alkyl]amino; Hetercyclyl-(C1-C7)-amino, Heterocyclyl-(C1-C6)-alkyl-amino, Heterocyclyl-[(C1-C7)-alkyl]amino; (C3-C7)-Cycloalkyl-amino, (C3-C7)-Cycloalkyl-[(C1- C7)-alkyl]amino; N-Azetidinyl, N-Pyrrolidinyl, N-Piperidinyl. N-Morpholinyl steht, R37 für Phenyl, 2-Fluorphenyl, 4-Fluorphenyl, 4-Brom-3-methylphenyl, 2-Chlorphenyl, 4- Chlorphenyl, 4-Acetylphenyl, 5-Chlor-2-methylphenyl, 2-Chlor-5-methylphenyl, 6- Chlorpyridin-3-yl, 2,5-Dimethylphenyl, 2,5-Difluorphenyl, 2,5-Dichlorphenyl, 6- Methylpyridin-2-yl, Pyridin-2-yl, 2,3-Dichlorphenyl, 2,6-Difluorphenyl, 2- Methylphenyl, 2,6-Dichlorphenyl, 2-Chlorpyridin-4-yl, Pyridazin-4-yl, 2- (Trifluormethyl)phenyl, 2-Cyanophenyl steht und m für 0, 1, 2 steht.

13. Substituierte N-Pyrrolidinone der allgemeinen Formel (I) gemäß Anspruch 11 oder deren Salze, worin R1 für (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, (C1-C10)-Haloalkyl, (C3-C10)- Cycloalkyl, (C3-C6)-Halocycloalkyl, (C4-C6)-Cycloalkenyl, Aryl, Aryl-(C1-C6)-Alkyl, Heteroaryl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-Alkyl, R32O- (C1-C6)-Alkyl, (C3-C10)-Cycloalkyl-(C1-C6)-Alkyl steht, R2 für Wasserstoff steht, R7 für eine der nachfolgenden Gruppen G-4 bis G-6 steht, wobei ein Pfeil für eine Bindung zum Pyrrolidinonring in der allgemeinen Formel (I) steht, R3, R4 unabhängig voneinander für Wasserstoff, (C1-C6)-Alkyl, (C1-C6)-Haloalkyl, (C3-C6)- Cycloalkyl, (C3-C6)-Cycloalkyl-(C1-C6)-Alkyl, OR32 stehen, R5, R6 unabhängig voneinander für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C1-C6)- Haloalkyl, (C3-C6)-Cycloalkyl, Aryl-(C1-C6)-Alkyl, Aryl, Heteroaryl, Heteroaryl- (C1-C6)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-Alkyl, R32O-(C1-C6)-Alkyl, R30R31N- (C1-C6)-Alkyl, NR30R31, OR32, (C3-C6)-Cycloalkyl-(C1-C6)-Alkyl stehen, R8, R9, R10 unabhängig voneinander für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)- Alkinyl, Aryl-(C1-C6)-Alkyl, Heteroaryl-(C1-C6)-Alkyl, C(O=)R32, (C1-C6)- Alkyloxycarbonyl, Aryl-(C1-C6)-Alkyloxycarbonyl stehen, R11, R12 unabhängig voneinander für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)- Alkinyl, (C1-C6)-Haloalkyl, (C3-C6)-Cycloalkyl, Aryl-(C1-C6)-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C1-C6)-Alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-Alkyl, R32O-(C1-C6)- Alkyl, R30R31N-(C1-C6)-Alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-Alkyl, C(=O)R32, C(=O)OR32, C(=O)NR30R31, R32O(O)C-(C1-C6)-Alkyl, R30R31N(O)C-(C1-C6)-Alkyl, OR32 stehen, R30 und R31 gleich oder verschieden sind und unabhängig voneinander für Wasserstoff, (C1-C6)- Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, (C1-C6)-Cyanoalkyl, (C1-C6)-Haloalkyl, (C2-C6)-Haloalkenyl, (C3-C6)-Haloalkinyl, (C3-C6)-Cycloalkyl, (C3-C6)-Halocycloalkyl, (C4-C6)-Cycloalkenyl, (C4-C6)-Halocycloalkenyl, (C1-C6)-Alkoxy-(C1-C6)-alkyl, (C1-C6)-Haloalkoxy-(C1-C6)-alkyl, (C1-C6)-Alkylthio-(C1-C6)-alkyl, (C1-C6)- Haloalkylthio-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)-haloalkyl, Aryl, Aryl-(C1-C6)- alkyl, Heteroaryl, Heteroaryl-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-alkyl, (C4-C6)- Cycloalkenyl-(C1-C6)-alkyl, COR32, SO2R33, Heterocyclyl, (C1-C6)-Alkoxycarbonyl, Bis-[(C1-C6)-alkyl]aminocarbonyl-(C1-C6)-alkyl, (C1-C6)-Alkyl-aminocarbonyl-(C1-C6)- alkyl, Aryl-(C1-C6)-alkyl-aminocarbonyl-(C1-C6)-alkyl, Aryl-(C1-C6)-alkoxycarbonyl, Heteroaryl-(C1-C6)-alkoxycarbonyl, (C2-C6)-Alkenyloxycarbonyl, (C2-C6)- Alkinyloxycarbonyl, (C1-C6)-Alkoxycarbonyl-(C1-C6)-alkyl, (C2-C6)- Alkenyloxycarbonyl-(C1-C6)-alkyl, (C2-C6)-Alkinyloxycarbonyl-(C1-C6)-alkyl, Aryl-(C1-C6)-alkoxycarbonyl-(C1-C6)-alkyl, Heteroaryl-(C1-C6)-alkoxycarbonyl- (C1-C6)-alkyl, Heterocyclyl-(C1-C6)-alkoxycarbonyl-(C1-C6)-alkyl, Heterocyclyl- (C1-C6)-alkyl stehen, oder R30 und R31 mit dem Stickstoffatom, an das sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 3 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, R32 für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, (C1-C6)-Cyanoalkyl, (C1-C6)-Haloalkyl, (C2-C6)-Haloalkenyl, (C3-C6)-Haloalkinyl, (C3-C6)-Cycloalkyl, (C3-C10)-Halocycloalkyl, (C4-C6)-Cycloalkenyl, (C4-C6)-Halocycloalkenyl, (C1-C6)- Alkoxy-(C1-C6)-alkyl, (C1-C6)-Haloalkoxy-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)- haloalkyl, (C1-C6)-Alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)- alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkoxy- (C1-C6)-alkoxy-(C1-C6)-alkyl, Aryl, Aryl-(C1-C6)-alkyl, Aryl-(C1-C6)-alkoxy-(C1-C6)- alkyl, Heteroaryl, Heteroaryl-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-alkyl, (C4-C6)- Cycloalkenyl-(C1-C6)-alkyl, Bis-[(C1-C6)-alkyl]aminocarbonyl-(C1-C6)-alkyl, (C1-C6)- Alkyl-aminocarbonyl-(C1-C6)-alkyl, Aryl-(C1-C6)-alkyl-aminocarbonyl-(C1-C6)-alkyl, Bis-[(C1-C6)-alkyl]amino-(C2-C6)-alkyl, (C1-C6)-Alkyl-amino-(C2-C6)-alkyl, Aryl-(C1- C6)-alkyl-amino-(C2-C6)-alkyl, R33(O)mS-(C1-C6)-alkyl, Hydroxycarbonyl-(C1-C6)-alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-alkyl, Tris-[(C1-C6)-Alkyl]silyl-(C1-C6)-alkyl, Bis- [(C1-C6)-Alkyl](aryl)silyl(C1-C6)-alkyl, [(C1-C6)-Alkyl]-bis-(aryl)silyl-(C1-C6)-alkyl, (C1-C6)-Alkylcarbonyloxy-(C1-C6)-alkyl, (C3-C6)-Cycloalkylcarbonyloxy-(C1-C6)-alkyl, Arylcarbonyloxy-(C1-C6)-alkyl, Heteroarylcarbonyloxy-(C1-C6)-alkyl, Heterocyclylcarbonyloxy-(C1-C6)-alkyl, Aryloxy-(C1-C6)-alkyl, Heteroaryloxy-(C1-C6)- alkyl, Heterocyclyloxy-(C1-C6)-alkyl, (C1-C6)-Alkoxycarbonyl, (C1-C6)- Alkoxycarbonyl-(C1-C6)-alkyl, (C2-C6)-Alkenyloxycarbonyl-(C1-C6)-alkyl, (C2-C6)- Alkinyloxycarbonyl-(C1-C6)-alkyl, Aryl-(C1-C6)-alkoxycarbonyl-(C1-C6)-alkyl, Heteroaryl-(C1-C6)-alkoxycarbonyl-(C1-C6)-alkyl, Heterocyclyl-(C1-C6)- alkoxycarbonyl-(C1-C6)-alkyl steht, R33 für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, (C1-C6)-Cyanoalkyl, (C1-C6)-Haloalkyl, (C2-C6)-Haloalkenyl, (C3-C6)-Haloalkinyl, (C3-C6)-Cycloalkyl, (C3-C6)-Halocycloalkyl, (C4-C6)-Cycloalkenyl, (C4-C6)-Halocycloalkenyl, (C1-C6)- Alkoxy-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)-haloalkyl, Aryl, Aryl-(C1-C6)-alkyl, Heteroaryl, Heteroaryl-(C1-C6)-alkyl, Heterocyclyl-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl- (C1-C6)-alkyl, (C4-C10)-Cycloalkenyl-(C1-C6)-alkyl, Bis-[(C1-C6)-alkyl]amino, (C1-C6)- Alkyl-amino, Aryl-(C1-C6)-amino, Aryl-(C1-C6)-alkyl-amino, Aryl-[(C1-C6)- alkyl]amino; Heteroaryl-(C1-C6)-amino, Heteroaryl-(C1-C6)-alkyl-amino, Heteroaryl- [(C1-C6)-alkyl]amino; Hetercyclyl-(C1-C6)-amino, Heterocyclyl-(C1-C6)-alkyl-amino, Heterocyclyl-[(C1-C6)-alkyl]amino; (C3-C6)-Cycloalkyl-amino, (C3-C6)-Cycloalkyl-[(C1- C6)-alkyl]amino; N-Azetidinyl, N-Pyrrolidinyl, N-Piperidinyl. N-Morpholinyl steht, R37 für Phenyl, 2-Fluorphenyl, 4-Fluorphenyl, 4-Brom-3-methylphenyl, 2-Chlorphenyl, 4- Chlorphenyl, 4-Acetylphenyl, 5-Chlor-2-methylphenyl, 2-Chlor-5-methylphenyl, 6- Chlorpyridin-3-yl, 2,5-Dimethylphenyl, 2,5-Difluorphenyl, 2,5-Dichlorphenyl, 6- Methylpyridin-2-yl, Pyridin-2-yl, 2,3-Dichlorphenyl, 2,6-Difluorphenyl, 2- Methylphenyl, 2,6-Dichlorphenyl, 2-Chlorpyridin-4-yl, Pyridazin-4-yl, 2- (Trifluormethyl)phenyl, 2-Cyanophenyl steht und m für 0, 1, 2 steht. 14. Sprühlösung zur Behandlung von Pflanzen, enthaltend eine zur Steigerung der Widerstandsfähigkeit von Pflanzen gegenüber abiotischen Stressfaktoren wirksame Menge einer oder mehrerer der substituierten N-Pyrrolidinone gemäß einem der Ansprüche 11 bis 13.
Description:
Bayer AG Verwendung von substituierten Pyrrolidinonen oder deren Salzen zur Steigerung der Stresstoleranz in Pflanzen. Beschreibung Die Erfindung betrifft die Verwendung von substituierten Pyrrolidinonen oder deren Salzen zur Steigerung der Stresstoleranz in Pflanzen gegenüber abiotischem Stress, sowie zur Steigerung des Pflanzenwachstums und/oder zur Erhöhung des Pflanzenertrags. Es ist bekannt, dass bestimmte substituierte Pyrrolidin-2-on-4-carboxamide und Pyrrolidin-2-on-4- essigsäureamide als pharmazeutische Wirkstoffe verwendet werden können, z. B. als Beta- Secretaseinhibitoren (vgl. z. B. WO2009/038412) oder als P2X7-Modulatoren für die Behandlung entzündlicher und neurodegenerativer Erkrankungen (vgl. z.B. WO2009/077559; WO2019/185868; Journal of Medicinal Chemistry (2020), 63(5), 2074-2094). Es ist weiter bekannt, dass bestimmte Pyrrolidinon-substituierte Beta-Oxocarboxamide als PLA2G16-Inhibitoren zur Behandlung von viralen Infektionen eingesetzt werden können (vgl. WO2019/068841). Die Wirkung von bestimmten Pyrrolidinon-substituierten Harnstoffen als Kinaseinhibitoren wird in WO2012/019015 beschrieben. Die Synthese von Pyrrolidin-2-on-5-essigsäureamiden wird in Chemistry – a European Journal, 2017, 23, 7428 und Tetrahedron: Asymmetry, 2004, 15, 3461 beschrieben. Ausgewählte Pyrrolidinon-substituierte Harnstoffe werden als Leitstrukturen zur Identifizierung von TRPV1-Modulatoren (vgl. Future Med. Chem.2015, 7, 243) oder ERK-Inhibitoren (vgl. WO2016/100050) beschrieben. Die Verwendung von bestimmten Pyrrolidin-2-on-4-carboxamiden als Leitstrukturen zur Identifizierung von Antituberkulosewirkstoffen oder von G Protein-gekoppelten Rezeptorkinaseinhibitoren ist ebenfalls beschrieben (Bioorg. Med. Chem.2010, 18, 6914; Bioorg. Med. Chem. Lett.2018, 28, 1507). Die Verwendung von Pyrrolidin-2-on-5-essigsäureamiden, Pyrrolidin-2-on-4-carboxamiden, Pyrrolidin-2- on-4-essigsäureamiden und Pyrrolidin-2-on-4-Harnstoffen gegen abiotischen Stress wird dagegen nicht beschrieben. Die Verwendung ausgewählter Arylsulfonamide als Wuchsregulatoren vor allem zur Beschränkung der Wuchslänge von Reis- und Weizenpflanzen mit dem Ziel der Minimierung des wetterbedingten Umknickens wird in DE 2544859 beschrieben, während die fungizide Wirkung bestimmter N- Cyanoalkylsulfonamide in EP176327A1 beschrieben wird. Es ist außerdem bekannt, dass substituierte N-Sulfonyl-aminoacetonitrile zur Kontrolle von Parasiten in Warmblütern eingesetzt werden können (vg. WO2004/000798). Die Verwendung von 1-(4-Methylphenyl)-N-(2-oxo-1-propyl-1,2,3,4- tetrahydrochinolin-6-yl)methansulfonamid gegen Trockenstress in Arabidopsis thaliana und Soja wird in Proc. Natl. Acad. Sci.2013, 110(29), 12132-12137 beschrieben. Die Verwendung von 1-(4- Methylphenyl)-N-(2-oxo-1-propyl-1,2,3,4-tetrahydrochinolin-6 -yl)methansulfonamid zur Steigerung der Stresstoleranz von Pflanzen wird ebenfalls in CN 104170823 beschrieben. Weitere 1-Aryl-N-(2-oxo-1- alkyl-1,2,3,4-tetrahydrochinolin-6-yl)methansulfonamide mit unverzweigter oder verzweigter, aber nicht weiter substituierter Alkylgruppe in der N-Tetrahydrochinolinyleinheit werden in WO2013/148339 beschrieben. In WO2013/148339 wird ebenfalls die agonistische Wirkung der betreffenden Substanzen an Abscisinsäurerezeptoren beschrieben. In WO2013/148339 werden weiterhin (2-Oxo-1,2,3,4- tetrahydrochinolin-6-yl)methansulfonamide mit unsubstituierten N-Cycloalkylresten beansprucht, während in WO2015/155154 die Wirkung von speziell substituierten (2-Oxo-1,2,3,4-tetrahydrochinolin- 6-yl)methansulfonamiden gegen abiotischen Stress sowie die agonistische Wirkung der betreffenden Substanzen an Abscisinsäure-rezeptoren beschrieben wird. In WO2015/049351 wird die Wirkung von Dihydrooxindolylsulfonamiden gegen abiotischen Stress in Pflanzen beschrieben. Die Verwendung von 3-Aminopyrrolidinonsulfonamiden gegen abiotischen Stress oder zur Steigerung des Pflanzenwachstums wird dagegen nicht beschrieben. Es ist bekannt, dass Pflanzen auf natürliche Stressbedingungen, wie beispielsweise Kälte-, Hitze-, Trockenstress (Stress verursacht durch Trockenheit und/oder Wassermangel), Verwundung, Pathogenbefall (Viren, Bakterien, Pilze, Insekten) etc. aber auch auf Herbizide mit spezifischen oder unspezifischen Abwehrmechanismen reagieren können [Pflanzenbiochemie, S.393-462 , Spektrum Akademischer Verlag, Heidelberg, Berlin, Oxford, Hans W. Heldt, 1996.; Biochemistry and Molecular Biology of Plants, S.1102-1203, American Society of Plant Physiologists, Rockville, Maryland, eds. Buchanan, Gruissem, Jones, 2000]. In Pflanzen sind zahlreiche Proteine und die sie codierenden Gene bekannt, die an Abwehrreaktionen gegen abiotischen Stress (z.B. Kälte, Hitze, Trockenheit, Salz, Überflutung) beteiligt sind. Diese gehören teilweise zu Signaltransduktionsketten (z.B. Transkriptionsfaktoren, Kinasen, Phosphatasen) oder bewirken eine physiologische Antwort der Pflanzenzelle (z.B. Ionentransport, Entgiftung reaktiver Sauerstoff-Spezies). Zu den Signalkettengenen der abiotischen Stressreaktion gehören u.a. Transkriptionsfaktoren der Klassen DREB und CBF (Jaglo-Ottosen et al., 1998, Science 280: 104-106). An der Reaktion auf Salzstress sind Phosphatasen vom Typ ATPK und MP2C beteiligt. Ferner wird bei Salzstress häufig die Biosynthese von Osmolyten wie Prolin oder Sucrose aktiviert. Beteiligt sind hier z.B. die Sucrose-Synthase und Prolin-Transporter (Hasegawa et al., 2000, Annu Rev Plant Physiol Plant Mol Biol 51: 463-499). Die Stressabwehr der Pflanzen gegen Kälte und Trockenheit benutzt z.T. die gleichen molekularen Mechanismen. Bekannt ist die Akkumulation von sogenannten Late Embryogenesis Abundant Proteins (LEA-Proteine), zu denen als wichtige Klasse die Dehydrine gehören (Ingram and Bartels, 1996, Annu Rev Plant Physiol Plant Mol Biol 47: 277-403, Close, 1997, Physiol Plant 100: 291-296). Es handelt sich dabei um Chaperone, die Vesikel, Proteine und Membranstrukturen in gestressten Pflanzen stabilisieren (Bray, 1993, Plant Physiol 103: 1035-1040). Außerdem erfolgt häufig eine Induktion von Aldehyd-Deydrogenasen, welche die bei oxidativem Stress entstehenden reaktiven Sauerstoff-Spezies (ROS) entgiften (Kirch et al., 2005, Plant Mol Biol 57: 315-332). Heat Shock Faktoren (HSF) und Heat Shock Proteine (HSP) werden bei Hitzestress aktiviert und spielen hier als Chaperone eine ähnliche Rolle wie die Dehydrine bei Kälte- und Trockenstress (Yu et al., 2005, Mol Cells 19: 328-333). Eine Reihe von pflanzenendogenen Signalstoffen, die in die Stresstoleranz bzw. die Pathogenabwehr involviert sind, sind bereits bekannt. Zu nennen sind hier beispielsweise Salicylsäure, Benzoesäure, Jasmonsäure oder Ethylen [Biochemistry and Molecular Biology of Plants, S.850-929, American Society of Plant Physiologists, Rockville, Maryland, eds. Buchanan, Gruissem, Jones, 2000]. Einige dieser Substanzen oder deren stabile synthetische Derivate und abgeleitete Strukturen sind auch bei externer Applikation auf Pflanzen oder Saatgutbeizung wirksam und aktivieren Abwehrreaktionen, die eine erhöhte Stress- bzw. Pathogentoleranz der Pflanze zur Folge haben [Sembdner, and Parthier, 1993, Ann. Rev. Plant Physiol. Plant Mol. Biol.44: 569-589]. Der Einfluss von pflanzlichen Metaboliten wie z.B. Aminosäuren wie Prolin oder Tryptophan, auf die Toleranz von Kulturpflanzen gegenüber abiotischem Stress ist ebenfalls beschrieben [Godoy et al.2021, Plants 10 (2): 186]. Pyrrolidin-2-on-5- essigsäureamiden, Pyrrolidin-2-on-4-carboxamiden, Pyrrolidin-2-on-4-essigsäureamiden und Pyrrolidin- 2-on-4-Harnstoffen werden in dieser Übersicht allerdings nicht beschrieben. Es ist weiter bekannt, dass chemische Substanzen die Toleranz von Pflanzen gegen abiotischen Stress erhöhen können. Derartige Substanzen werden dabei entweder durch Saatgut-Beizung, durch Blattspritzung oder durch Bodenbehandung appliziert. So wird eine Erhöhung der abiotischen Stresstoleranz von Kulturpflanzen durch Behandlung mit Elicitoren der Systemic Acquired Resistance (SAR) oder Abscisinsäure-Derivaten beschrieben (Schading and Wei, WO2000/28055; Abrams and Gusta, US5201931; Abrams et al, WO97/23441, Churchill et al., 1998, Plant Growth Regul 25: 35-45). Desweiteren wurden Effekte von Wachstumsregulatoren auf die Stresstoleranz von Kulturpflanzen beschrieben (Morrison and Andrews, 1992, J Plant Growth Regul 11: 113-117, RD-259027). In diesem Zusammenhang ist ebenfalls bekannt, dass ein wachstumsregulierendes Naphthylsulfonamid (4-Brom- N-(pyridin-2-ylmethyl)naphthalin-1-sulfonamid) die Keimung von Pflanzensamen in der gleichen Weise wie Abscisinsäure beeinflusst (Park et al. Science 2009, 324, 1068-1071). Weiterhin zeigt eine Naphthylsulfamidocarbonsäure (N-[(4-Brom-1-naphthyl)sulfonyl]-5-methoxynorvalin) eine Wirkungsweise in biochemischen Rezeptortests, die mit 4-Brom-N-(pyridin-2-ylmethyl)naphthalin-1- sulfonamid vergleichbar ist (Melcher et al. Nature Structural & Molecular Biology 2010, 17, 1102- 1108). Außerdem ist bekannt, dass ein weiteres Naphthylsulfonamid, N-(6-aminohexyl)-5- chlornaphthalin-1-sulfonamid, den Calcium-Spiegel in Pflanzen beeinflusst, die einem Kälteschock ausgesetzt wurden (Cholewa et al. Can. J. Botany 1997, 75, 375-382). Auch bei Anwendung von Fungiziden, insbesondere aus der Gruppe der Strobilurine oder der Succinat Dehydrogenase Inhibitoren werden ähnliche Effekte beobachtet, die häufig auch mit einer Ertragssteigerung einhergehen (Draber et al., DE 3534948, Bartlett et al., 2002, Pest Manag Sci 60: 309). Es ist ebenfalls bekannt, dass das Herbizid Glyphosat in niedriger Dosierung das Wachstum einiger Pflanzenarten stimuliert (Cedergreen, Env. Pollution 2008, 156, 1099). Bei osmotischem Stress ist eine Schutzwirkung durch Applikation von Osmolyten wie z.B. Glycinbetain oder deren biochemischen Vorstufen, z.B. Cholin-Derivate beobachtet worden (Chen et al., 2000, Plant Cell Environ 23: 609-618, Bergmann et al., DE 4103253). Auch die Wirkung von Antioxidantien wie z.B Naphthole und Xanthine zur Erhöhung der abiotischen Stresstoleranz in Pflanzen wurde bereits beschrieben (Bergmann et al., DD 277832, Bergmann et al., DD 277835). Die molekularen Ursachen der Anti-Stress-Wirkung dieser Substanzen sind jedoch weitgehend unbekannt. Es ist weiter bekannt, dass die Toleranz von Pflanzen gegenüber abiotischem Stress durch eine Modifikation der Aktivität von endogenen Poly-ADP-ribose Polymerasen (PARP) oder Poly-(ADP- ribose) glycohydrolasen (PARG) erhöht werden kann (de Block et al., The Plant Journal, 2004, 41, 95; Levine et al., FEBS Lett.1998, 440, 1; WO00/04173; WO2004/090140). Somit ist bekannt, dass Pflanzen über mehrere endogene Reaktionsmechanismen verfügen, die eine wirksame Abwehr gegenüber verschiedensten Schadorganismen und/oder natürlichem abiotischem Stress bewirken können. Da sich die ökologischen und ökonomischen Anforderungen an moderne Pflanzenbehandlungsmittel laufend erhöhen, beispielsweise was deren Toxizität, Selektivität, Aufwandmenge, Rückstandsbildung und günstige Herstellbarkeit angeht, besteht die ständige Aufgabe, neue Pflanzenbehandlungsmittel zu entwickeln, die zumindest in Teilbereichen Vorteile gegenüber den bekannten aufweisen. Daher bestand die Aufgabe der vorliegenden Erfindung darin, Verbindungen bereitzustellen, die die Toleranz gegenüber abiotischem Stress in Pflanzen weiter erhöhen, eine Stärkung des Pflanzenwachstums bewirken und/oder zur Erhöhung des Pflanzenertrags beitragen. In diesem Zusammenhang wird unter Toleranz gegenüber abiotischem Stress beispielsweise die Toleranz gegenüber Kälte-, Hitze-, Trockenstress (Stress verursacht durch Trockenheit und/oder Wassermangel), Salzen und Überflutung verstanden. Überraschenderweise wurde nun gefunden, dass substituierte Pyrrolidinone zur Steigerung der Stresstoleranz in Pflanzen gegenüber abiotischem Stress, sowie zur Steigerung des Pflanzenwachstums und/oder zur Erhöhung des Pflanzenertrags verwendet werden können. Gegenstand der vorliegenden Erfindung ist demnach die Verwendung substituierter Pyrrolidinone der allgemeinen Formel (I) oder deren Salze zur Steigerung der Stresstoleranz in Pflanzen gegenüber abiotischem Stress, sowie zur Steigerung des Pflanzenwachstums und/oder zur Erhöhung des Pflanzenertrags, worin R 1 für Wasserstoff, NR 30 R 31 , OR 32 , S(O) m R 33 , (C 1 -C 8 )-Alkyl, (C 2 -C 8 )-Alkenyl, (C 2 -C 8 )-Alkinyl, (C 1 -C 10 )-Haloalkyl, (C 2 -C 8 )-Haloalkenyl, (C 2 -C 8 )-Haloalkinyl, (C 3 -C 10 )-Cycloalkyl, (C 3 -C 10 )- Halocycloalkyl, (C 4 -C 10 )-Cycloalkenyl, (C 4 -C 10 )-Halocycloalkenyl, Aryl, Aryl-(C 1 -C 8 )-Alkyl, Heteroaryl, Heteroaryl-(C 1 -C 8 )-Alkyl, Heterocyclyl, Heterocyclyl-(C 1 -C 8 )-Alkyl, R 32 O-(C 1 -C 8 )- Alkyl, R 30 R 31 N-(C 1 -C 8 )-Alkyl, R 32 O(O)C-(C 1 -C 8 )-Alkyl, R 30 R 31 N(O)C-(C 1 -C 8 )-Alkyl, (C 3 -C 10 )- Cycloalkyl-(C 1 -C 8 )-Alkyl, R 33 S(O)m-(C 1 -C 8 )-alkyl, R 32 (O=)C-(C 1 -C 8 )-Alkyl, C(=O)R 32 , C(=O)OR 32 steht, m für 0, 1, 2 steht, R 3 und R 4 unabhängig voneinander für Wasserstoff, (C 1 -C 8 )-Alkyl, (C 2 -C 8 )-Alkenyl, (C 1 -C 10 )-Haloalkyl, (C 3 -C 10 )-Cycloalkyl, (C 3 -C 10 )-Cycloalkyl-(C 1 -C 8 )-Alkyl, Aryl-(C 1 -C 8 )-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C 1 -C 8 )-Alkyl, Heterocyclyl, Heterocyclyl-(C 1 -C 8 )-Alkyl, R 32 O-(C 1 -C 8 )-Alkyl, R 30 R 31 N-(C 1 -C 8 )-Alkyl stehen, R 5 , R 6 unabhängig voneinander für Wasserstoff, (C 1 -C 8 )-Alkyl, (C 2 -C 8 )-Alkenyl, (C 1 -C 10 )-Haloalkyl, (C 3 -C 10 )-Cycloalkyl, Aryl-(C 1 -C 8 )-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C 1 -C 8 )-Alkyl, Heterocyclyl, Heterocyclyl-(C 1 -C 8 )-Alkyl, R 32 O-(C 1 -C 8 )-Alkyl, R 30 R 31 N-(C 1 -C 8 )-Alkyl, NR 30 R 31 , OR 32 , (C 3 -C 10 )-Cycloalkyl-(C 1 -C 8 )-Alkyl stehen, R 3 und R 5 mit den Kohlenstoffatomen, an die sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 5 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, R 2 für Wasserstoff und eine der nachfolgenden Gruppen G-1 bis G-2 steht, wobei ein Pfeil für eine Bindung zum Pyrrolidinonring in der allgemeinen Formel (I) steht, R 7 für Wasserstoff und eine der nachfolgenden Gruppen G-1 bis G-15 steht, wobei ein Pfeil für eine Bindung zum Pyrrolidinonring in der allgemeinen Formel (I) steht, mit der Maßgabe, dass R 2 und R 7 nicht gleichzeitig H sind und dass R 7 für H steht, wenn R 2 für eine der nachfolgenden Gruppen G-1 bis G-2 steht, und dass R 2 für H steht, wenn R 7 für eine der nachfolgenden Gruppen G-1 bis G-15 steht, R 8 , R 9 , R 10 , R 15 , R 18 , R 19 , R 20 unabhängig voneinander für Wasserstoff, (C 1 -C 8 )-Alkyl, (C 2 -C 8 )-Alkenyl, (C 2 --C 8 )-Alkinyl, Aryl-(C 1 -C 8 )-Alkyl, Heteroaryl-(C 1 -C 8 )-Alkyl, Heterocyclyl-(C 1 -C 8 )-Alkyl, R 32 O-(C 1 -C 8 )-Alkyl, (C 3 -C 10 )-Cycloalkyl-(C 1 -C 8 )-Alkyl, S(O)mR 33 , R 32 (O=)C-(C 1 -C 8 )-Alkyl, C(O=)R 32 , (C 1 -C 8 )-Alkyloxycarbonyl, Aryl-(C 1 -C 8 )-Alkyloxycarbonyl stehen, R 8 und R 9 mit den Stickstoffatomen, an die sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 5 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, R 11 , R 12 , R 13 , R 14 unabhängig voneinander für Wasserstoff, (C 1 -C 8 )-Alkyl, (C 2 -C 8 )-Alkenyl, (C 2 -C 8 )- Alkinyl, (C 1 -C 10 )-Haloalkyl, (C 3 -C 10 )-Cycloalkyl, Aryl-(C 1 -C 8 )-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C 1 -C 8 )-Alkyl, Heterocyclyl, Heterocyclyl-(C 1 -C 8 )-Alkyl, R 32 O-(C 1 -C 8 )-Alkyl, R 30 R 31 N-(C 1 -C 8 )-Alkyl, (C 3 -C 10 )-Cycloalkyl-(C 1 -C 8 )-Alkyl, C(=O)R 32 , C(=O)OR 32 , C(=O)NR 30 R 31 , R 32 O(O)C-(C 1 -C 8 )-Alkyl, R 30 R 31 N(O)C-(C 1 -C 8 )-Alkyl, OR 32 stehen, R 16 , R 17 , R 21 , R 22 unabhängig voneinander für Wasserstoff, (C 1 -C 8 )-Alkyl, (C 2 -C 8 )-Alkenyl, (C 2 -C 8 )- Alkinyl, (C 1 -C 10 )-Haloalkyl, (C 3 -C 10 )-Cycloalkyl, Aryl-(C 1 -C 8 )-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C 1 -C 8 )-Alkyl, Heterocyclyl, Heterocyclyl-(C 1 -C 8 )-Alkyl, R 32 O-(C 1 -C 8 )-Alkyl, R 30 R 31 N-(C 1 -C 8 )-Alkyl, (C 3 -C 10 )-Cycloalkyl-(C 1 -C 8 )-Alkyl, C(=O)R 32 , C(=O)OR 32 , C(=O)NR 30 R 31 stehen, R 23 , R 24 unabhängig voneinander für Wasserstoff, (C 1 -C 8 )-Alkyl, (C 1 -C 10 )-Haloalkyl, (C 3 -C 10 )- Cycloalkyl, Aryl-(C 1 -C 8 )-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C 1 -C 8 )-Alkyl, Heterocyclyl, Heterocyclyl-(C 1 -C 8 )-Alkyl, R 32 O-(C 1 -C 8 )-Alkyl, R 30 R 31 N-(C 1 -C 8 )-Alkyl, (C 3 -C 10 )-Cycloalkyl- (C 1 -C 8 )-Alkyl, C(O=)R 32 , (C 1 -C 8 )-Alkyloxycarbonyl, Aryl-(C 1 -C 8 )-Alkyloxycarbonyl stehen, R 25 , R 28 , R 29 unabhängig voneinander für Wasserstoff, (C 1 -C 8 )-Alkyl, (C 2 -C 8 )-Alkenyl, (C 2 -C 8 )-Alkinyl, Aryl-(C 1 -C 8 )-Alkyl, Heteroaryl-(C 1 -C 8 )-Alkyl, Heterocyclyl-(C 1 -C 8 )-Alkyl, R 32 O-(C 1 -C 8 )-Alkyl, (C 3 -C 10 )-Cycloalkyl-(C 1 -C 8 )-Alkyl, R 32 (O=)C-(C 1 -C 8 )-Alkyl stehen, R 26 , R 27 unabhängig voneinander für Wasserstoff, (C 1 -C 8 )-Alkyl, (C 1 -C 10 )-Haloalkyl, (C 3 -C 10 )- Cycloalkyl, (C 3 -C 10 )-Cycloalkyl-(C 1 -C 8 )-Alkyl, Aryl-(C 1 -C 8 )-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C 1 -C 8 )-Alkyl, Heterocyclyl, Heterocyclyl-(C 1 -C 8 )-Alkyl stehen, R 30 und R 31 unabhängig voneinander für Wasserstoff, (C 1 -C 8 )-Alkyl, (C 2 -C 8 )-Alkenyl, (C 2 -C 8 )-Alkinyl, (C 1 -C 8 )-Cyanoalkyl, (C 1 -C 10 )-Haloalkyl, (C 2 -C 8 )-Haloalkenyl, (C 3 -C 8 )-Haloalkinyl, (C 3 -C 10 )- Cycloalkyl, (C 3 -C 10 )-Halocycloalkyl, (C 4 -C 10 )-Cycloalkenyl, (C 4 -C 10 )-Halocycloalkenyl, (C 1 -C 8 )-Alkoxy-(C 1 -C 8 )-alkyl, (C 1 -C 8 )-Haloalkoxy-(C 1 -C 8 )-alkyl, (C 1 -C 8 )-Alkylthio-(C 1 -C 8 )- alkyl, (C 1 -C 8 )-Haloalkylthio-(C 1 -C 8 )-alkyl, (C 1 -C 8 )-Alkoxy-(C 1 -C 8 )-haloalkyl, Aryl, Aryl- (C 1 -C 8 )-alkyl, Heteroaryl, Heteroaryl-(C 1 -C 8 )-alkyl, (C 3 -C 8 )-Cycloalkyl-(C 1 -C 8 )-alkyl, (C 4 -C 10 )- Cycloalkenyl-(C 1 -C 8 )-alkyl, COR 32 , SO 2 R 33 , Heterocyclyl, (C 1 -C 8 )-Alkoxycarbonyl, Bis-[(C 1 - C 8 )-alkyl]aminocarbonyl-(C 1 -C 8 )-alkyl, (C 1 -C 8 )-Alkyl-aminocarbonyl-(C 1 -C 8 )-alkyl, Aryl-(C 1 - C 8 )-alkyl-aminocarbonyl-(C 1 -C 8 )-alkyl, Aryl-(C 1 -C 8 )-alkoxycarbonyl, Heteroaryl-(C 1 -C 8 )- alkoxycarbonyl, (C 2 -C 8 )-Alkenyloxycarbonyl, (C 2 -C 8 )-Alkinyloxycarbonyl, Heterocyclyl- (C 1 -C 8 )-alkyl, (C 1 -C 8 )-Alkoxycarbonyl-(C 1 -C 8 )-alkyl, (C 2 -C 8 )-Alkenyloxycarbonyl- (C 1 -C 8 )-alkyl, (C 2 -C 8 )-Alkinyloxycarbonyl-(C 1 -C 8 )-alkyl, Aryl-(C 1 -C 8 )-alkoxycarbonyl- (C 1 -C 8 )-alkyl, Heteroaryl-(C 1 -C 8 )-alkoxycarbonyl-(C 1 -C 8 )-alkyl, Heterocyclyl-(C 1 -C 8 )- a lkoxycarbonyl-(C1-C8)-alkyl stehen, oder R 30 und R 31 mit dem Stickstoffatom, an das sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 3 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, R 32 für Wasserstoff, (C 1 -C 8 )-Alkyl, (C 2 -C 8 )-Alkenyl, (C 2 -C 8 )-Alkinyl, (C 1 -C 8 )-Cyanoalkyl, (C 1 -C 10 )- Haloalkyl, (C 2 -C 8 )-Haloalkenyl, (C 3 -C 8 )-Haloalkinyl, (C 3 -C 10 )-Cycloalkyl, (C 3 -C 10 )- Halocycloalkyl, (C 4 -C 10 )-Cycloalkenyl, (C 4 -C 10 )-Halocycloalkenyl, (C 1 -C 8 )-Alkoxy-(C 1 -C 8 )- alkyl, (C 1 -C 8 )-Haloalkoxy-(C 1 -C 8 )-alkyl, (C 1 -C 8 )-Alkoxy-(C 1 -C 8 )-haloalkyl, (C 1 -C 8 )-Alkoxy- (C 1 -C 8 )-alkoxy-(C 1 -C 8 )-alkyl, (C 1 -C 8 )-Alkoxy-(C 1 -C 8 )-alkoxy-(C 1 -C 8 )-alkoxy-(C 1 -C 8 )-alkyl, (C 1 -C 8 )-Alkoxy-(C 1 -C 8 )-alkoxy-(C 1 -C 8 )-alkoxy-(C 1 -C 8 )-alkoxy-(C 1 -C 8 )-alkyl, Aryl, Aryl- (C 1 -C 8 )-alkyl, Aryl-(C 1 -C 8 )-alkoxy-(C 1 -C 8 )-alkyl, Heteroaryl, Heteroaryl-(C 1 -C 8 )-alkyl, (C 3 -C 8 )- Cycloalkyl-(C 1 -C 8 )-alkyl, (C 4 -C 10 )-Cycloalkenyl-(C 1 -C 8 )-alkyl, Bis-[(C 1 -C 8 )- alkyl]aminocarbonyl-(C 1 -C 8 )-alkyl, (C 1 -C 8 )-Alkyl-aminocarbonyl-(C 1 -C 8 )-alkyl, Aryl-(C 1 -C 8 )- alkyl-aminocarbonyl-(C 1 -C 8 )-alkyl, Bis-[(C 1 -C 8 )-alkyl]amino-(C 2 -C 6 )-alkyl, (C 1 -C 8 )-Alkyl- amino-(C 2 -C 6 )-alkyl, Aryl-(C 1 -C 8 )-alkyl-amino-(C 2 -C 6 )-alkyl, R 33 (O)mS-(C 1 -C 8 )-alkyl, Hydroxycarbonyl-(C 1 -C 8 )-alkyl, Heterocyclyl, Heterocyclyl-(C 1 -C 8 )-alkyl, Tris-[(C 1 -C 8 )- Alkyl]silyl-(C 1 -C 8 )-alkyl, Bis-[(C 1 -C 8 )-Alkyl](aryl)silyl(C 1 -C 8 )-alkyl, [(C 1 -C 8 )-Alkyl]-bis- (aryl)silyl-(C 1 -C 8 )-alkyl, (C 1 -C 8 )-Alkylcarbonyloxy-(C 1 -C 8 )-alkyl, (C 3 -C 8 )- Cycloalkylcarbonyloxy-(C 1 -C 8 )-alkyl, Arylcarbonyloxy-(C 1 -C 8 )-alkyl, Heteroarylcarbonyloxy- (C 1 -C 8 )-alkyl, Heterocyclylcarbonyloxy-(C 1 -C 8 )-alkyl, Aryloxy-(C 1 -C 8 )-alkyl, Heteroaryloxy- (C 1 -C 8 )-alkyl, Heterocyclyloxy-(C 1 -C 8 )-alkyl, (C 1 -C 8 )-Alkoxycarbonyl, (C 1 -C 8 )- Alkoxycarbonyl-(C 1 -C 8 )-alkyl, (C 2 -C 8 )-Alkenyloxycarbonyl-(C 1 -C 8 )-alkyl, (C 2 -C 8 )- Alkinyloxycarbonyl-(C 1 -C 8 )-alkyl, Aryl-(C 1 -C 8 )-alkoxycarbonyl-(C 1 -C 8 )-alkyl, Heteroaryl-(C 1 -C 8 )-alkoxycarbonyl-(C 1 -C 8 )-alkyl, Heterocyclyl-(C 1 -C 8 )- alkoxycarbonyl-(C 1 -C 8 )-alkyl steht, R 33 für Wasserstoff, (C 1 -C 8 )-Alkyl, (C 2 -C 8 )-Alkenyl, (C 2 -C 8 )-Alkinyl, (C 1 -C 8 )-Cyanoalkyl, (C 1 -C 10 )- Haloalkyl, (C 2 -C 8 )-Haloalkenyl, (C 3 -C 8 )-Haloalkinyl, (C 3 -C 10 )-Cycloalkyl, (C 3 -C 10 )- Halocycloalkyl, (C 4 -C 10 )-Cycloalkenyl, (C 4 -C 10 )-Halocycloalkenyl, (C 1 -C 8 )-Alkoxy-(C 1 -C 8 )- alkyl, (C 1 -C 8 )-Alkoxy-(C 1 -C 8 )-haloalkyl, Aryl, Aryl-(C 1 -C 8 )-alkyl, Heteroaryl, Heteroaryl- (C 1 -C 8 )-alkyl, Heterocyclyl-(C 1 -C 8 )-alkyl, (C 3 -C 8 )-Cycloalkyl-(C 1 -C 8 )-alkyl, (C 4 -C 10 )- Cycloalkenyl-(C 1 -C 8 )-alkyl, Bis-[(C 1 -C 8 )-alkyl]amino, (C 1 -C 8 )-Alkyl-amino, Aryl-(C 1 -C 8 )- amino, Aryl-(C 1 -C 6 )-alkyl-amino, Aryl-[(C 1 -C 8 )-alkyl]amino; Heteroaryl-(C 1 -C 8 )-amino, Heteroaryl-(C 1 -C 6 )-alkyl-amino, Heteroaryl-[(C 1 -C 8 )-alkyl]amino; Hetercyclyl-(C 1 -C 8 )-amino, Heterocyclyl-(C 1 -C 6 )-alkyl-amino, Heterocyclyl-[(C 1 -C 8 )-alkyl]amino; (C 3 -C 8 )-Cycloalkyl- amino, (C 3 -C 8 )-Cycloalkyl-[(C 1 -C 8 )-alkyl]amino; N-Azetidinyl, N-Pyrrolidinyl, N-Piperidinyl. N-Morpholinyl steht, R 34 für Wasserstoff, (C 1 -C 8 )-Alkyl, (C 2 -C 8 )-Alkenyl, Aryl-(C 1 -C 8 )-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C 1 -C 8 )-Alkyl, Heterocyclyl, Heterocyclyl-(C 1 -C 8 )-Alkyl, R 32 O-(C 1 -C 8 )-Alkyl, R 30 R 31 N-(C 1 -C 8 )-Alkyl, NR 30 R 31 , (C 3 -C 10 )-Cycloalkyl-(C 1 -C 8 )-Alkyl, S(O)mR 33 steht, R 35 für Wasserstoff, NR 30 R 31 , OR 32 , (C 1 -C 8 )-Alkyl, (C 2 -C 8 )-Alkenyl, (C 2 -C 8 )-Alkinyl, Aryl, Aryl- (C 1 -C 8 )-Alkyl, Heteroaryl, Heteroaryl-(C 1 -C 8 )-Alkyl, Heterocyclyl, Heterocyclyl-(C 1 -C 8 )-Alkyl, R 32 O-(C 1 -C 8 )-Alkyl, (C 3 -C 10 )-Cycloalkyl, (C 3 -C 10 )-Cycloalkyl-(C 1 -C 8 )-Alkyl, S(O)mR 33 , R 32 (O=)C-(C 1 -C 8 )-Alkyl, R 32 O(O)C-(C 1 -C 8 )-Alkyl, R 30 R 31 N(O)C-(C 1 -C 8 )-Alkyl, R 33 S(O)m- (C 1 -C 8 )-alkyl, R 32 O-(C 1 -C 8 )-Alkyl, R 30 R 31 N-(C 1 -C 8 )-Alkyl steht, R 36 für Wasserstoff, (C 1 -C 8 )-Alkyl, (C 2 -C 8 )-Alkenyl, (C 2 -C 8 )-Alkinyl, Aryl, Aryl-(C 1 -C 8 )-Alkyl, Heteroaryl, Heteroaryl-(C 1 -C 8 )-Alkyl, Heterocyclyl, Heterocyclyl-(C 1 -C 8 )-Alkyl, (C 3 -C 10 )- Cycloalkyl, (C 3 -C 10 )-Cycloalkyl-(C 1 -C 8 )-Alkyl, R 32 (O=)C-(C 1 -C 8 )-Alkyl, R 32 O(O)C-(C 1 -C 8 )- Alkyl, R 30 R 31 N(O)C-(C 1 -C 8 )-Alkyl, R 33 S(O)m-(C 1 -C 8 )-alkyl, R 32 O-(C 1 -C 8 )-Alkyl, R 30 R 31 N- (C 1 -C 8 )-Alkyl steht, R 37 für (C 1 -C 8 )-Alkyl, (C 2 -C 8 )-Alkenyl, (C 2 -C 8 )-Alkinyl, (C 1 -C 10 )-Haloalkyl, (C 2 -C 8 )-Haloalkenyl, (C 2 -C 8 )-Haloalkinyl, (C 3 -C 10 )-Cycloalkyl, (C 3 -C 10 )-Halocycloalkyl, (C 4 -C 10 )-Cycloalkenyl, (C 4 -C 10 )-Halocycloalkenyl, Aryl, Aryl-(C 1 -C 8 )-Alkyl, Heteroaryl, Heteroaryl-(C 1 -C 8 )-Alkyl, Heterocyclyl, Heterocyclyl-(C 1 -C 8 )-Alkyl, Heteroaryloxy-(C 1 -C 8 )-Alkyl, Aryloxy-(C 1 -C 8 )- Alkyl, Heterocyclyloxy-(C 1 -C 8 )-Alkyl, R 32 O-(C 1 -C 8 )-Alkyl, R 30 R 31 N-(C 1 -C 8 )-Alkyl, R 32 O(O)C- (C 1 -C 8 )-Alkyl, R 30 R 31 N(O)C-(C 1 -C 8 )-Alkyl, (C 3 -C 10 )-Cycloalkyl-(C 1 -C 8 )-Alkyl, R 33 S(O) m - (C 1 -C 8 )-alkyl, R 32 (O=)C-(C 1 -C 8 )-Alkyl steht und R 38 für (C 1 -C 8 )-Alkyl, (C 2 -C 8 )-Alkenyl, (C 2 -C 8 )-Alkinyl, Aryl, Aryl-(C 1 -C 8 )-Alkyl, Heteroaryl, Heteroaryl-(C 1 -C 8 )-Alkyl, Heterocyclyl, Heterocyclyl-(C 1 -C 8 )-Alkyl, (C 3 -C 10 )-Cycloalkyl, (C 3 -C 10 )-Cycloalkyl-(C 1 -C 8 )-Alkyl, R 32 (O=)C-(C 1 -C 8 )-Alkyl, R 32 O(O)C-(C 1 -C 8 )-Alkyl, R 30 R 31 N(O)C-(C 1 -C 8 )-Alkyl, R 33 S(O) m -(C 1 -C 8 )-alkyl, R 32 O-(C 1 -C 8 )-Alkyl, R 30 R 31 N-(C 1 -C 8 )- Alkyl steht. Die Verbindungen der allgemeinen Formel (I) können durch Anlagerung einer geeigneten anorganischen oder organischen Säure, wie beispielsweise Mineralsäuren, wie beispielsweise HCl, HBr, H 2 SO 4 , H 3 PO 4 oder HNO 3 , oder organische Säuren, z. B. Carbonsäuren, wie Ameisensäure, Essigsäure, Propionsäure, Oxalsäure, Milchsäure oder Salicylsäure oder Sulfonsäuren, wie zum Beispiel p- Toluolsulfonsäure, an eine basische Gruppe, wie z.B. Amino, Alkylamino, Dialkylamino, Piperidino, Morpholino oder Pyridino, Salze bilden. Diese Salze enthalten dann die konjugierte Base der Säure als Anion. Geeignete Substituenten, die in deprotonierter Form, wie z.B. Sulfonsäuren, bestimmte Sulfonsäureamide oder Carbonsäuren, vorliegen, können innere Salze mit ihrerseits protonierbaren Gruppen, wie Aminogruppen bilden. Salzbildung kann auch durch Einwirkung einer Base auf Verbindungen der allgemeinen Formel (I) erfolgen. Geeignete Basen sind beispielsweise organische Amine, wie Trialkylamine, Morpholin, Piperidin und Pyridin sowie Ammonium-, Alkali- oder Erdalkalimetallhydroxide, -carbonate und -hydrogencarbonate, insbesondere Natrium- und Kaliumhydroxid, Natrium- und Kaliumcarbonat und Natrium- und Kaliumhydrogencarbonat. Diese Salze sind Verbindungen, in denen der acide Wasserstoff durch ein für die Landwirtschaft geeignetes Kation ersetzt wird, beispielsweise Metallsalze, insbesondere Alkalimetall-salze oder Erdalkalimetallsalze, insbesondere Natrium- und Kaliumsalze, oder auch Ammoniumsalze, Salze mit organischen Aminen oder quartäre Ammoniumsalze, zum Beispiel mit Kationen der Formel [NR a R b R c R d ] + , worin R a bis R d jeweils unabhängig voneinander einen organischen Rest, insbesondere Alkyl, Aryl, Aralkyl oder Alkylaryl darstellen. Infrage kommen auch Alkylsulfonium- und Alkylsulfoxoniumsalze, wie (C 1 -C 4 )-Trialkylsulfonium- und (C 1 -C 4 )-Trialkylsulfoxoniumsalze. Im Folgenden werden die erfindungsgemäß verwendeten Verbindungen der Formel (I) und ihre Salze "Verbindungen der allgemeinen Formel (I)" bezeichnet. Bevorzugter Erfindungsgegenstand ist die Verwendung von Verbindungen der allgemeinen Formel (I), worin R 1 für Wasserstoff, NR 30 R 31 , OR 32 , S(O)mR 33 , (C 1 -C 7 )-Alkyl, (C 2 -C 7 )-Alkenyl, (C 2 -C 7 )-Alkinyl, (C 1 -C 7 )-Haloalkyl, (C 2 -C 7 )-Haloalkenyl, (C 2 -C 7 )-Haloalkinyl, (C 3 -C 7 )-Cycloalkyl, (C 3 -C 7 )- Halocycloalkyl, (C 4 -C 7 )-Cycloalkenyl, (C 4 -C 7 )-Halocycloalkenyl, Aryl, Aryl-(C 1 -C 7 )-Alkyl, Heteroaryl, Heteroaryl-(C 1 -C 7 )-Alkyl, Heterocyclyl, Heterocyclyl-(C 1 -C 7 )-Alkyl, R 32 O-(C 1 -C 7 )- Alkyl, R 30 R 31 N-(C 1 -C 7 )-Alkyl, R 32 O(O)C-(C 1 -C 7 )-Alkyl, R 30 R 31 N(O)C-(C 1 -C 7 )-Alkyl, (C 3 -C 10 )- Cycloalkyl-(C 1 -C 7 )-Alkyl, R 33 S(O) m -(C 1 -C 7 )-alkyl, R 32 (O=)C-(C 1 -C 7 )-Alkyl, C(=O)R 32 , C(=O)OR 32 steht, m für 0, 1, 2 steht, R 3 und R 4 unabhängig voneinander für Wasserstoff, (C 1 -C 7 )-Alkyl, (C 2 -C 7 )-Alkenyl, (C 1 -C 10 )-Haloalkyl, (C 3 -C 7 )-Cycloalkyl, (C 3 -C 7 )-Cycloalkyl-(C 1 -C 7 )-Alkyl, Aryl-(C 1 -C 7 )-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C 1 -C 7 )-Alkyl, Heterocyclyl, Heterocyclyl-(C 1 -C 7 )-Alkyl, R 32 O-(C 1 -C 7 )-Alkyl, R 30 R 31 N-(C 1 -C 7 )-Alkyl stehen, R 5 , R 6 unabhängig voneinander für Wasserstoff, (C 1 -C 7 )-Alkyl, (C 2 -C 7 )-Alkenyl, (C 1 -C 7 )-Haloalkyl, (C 3 -C 7 )-Cycloalkyl, Aryl-(C 1 -C 7 )-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C 1 -C 7 )-Alkyl, Heterocyclyl, Heterocyclyl-(C 1 -C 7 )-Alkyl, R 32 O-(C 1 -C 7 )-Alkyl, R 30 R 31 N-(C 1 -C 7 )-Alkyl, NR 30 R 31 , OR 32 , (C 3 -C 7 )-Cycloalkyl-(C 1 -C 7 )-Alkyl stehen, R 3 und R 5 mit den Kohlenstoffatomen, an die sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 5 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, R 2 für Wasserstoff und eine der nachfolgenden Gruppen G-1 bis G-2 steht, wobei ein Pfeil für eine Bindung zum Pyrrolidinonring in der allgemeinen Formel (I) steht, R 7 für Wasserstoff und eine der nachfolgenden Gruppen G-1 bis G-15 steht, wobei ein Pfeil für eine Bindung zum Pyrrolidinonring in der allgemeinen Formel (I) steht, mit der Maßgabe, dass R 2 und R 7 nicht gleichzeitig H sind und dass R 7 für H steht, wenn R 2 für eine der nachfolgenden Gruppen G-1 bis G-2 steht, und dass R 2 für H steht, wenn R 7 für eine der nachfolgenden Gruppen G-1 bis G-15 steht,

' R 8 , R 9 , R 10 , R 15 , R 18 , R 19 , R 20 unabhängig voneinander für Wasserstoff, (C 1 -C 7 )-Alkyl, (C 2 -C 7 )-Alkenyl, (C 2 -C 7 )-Alkinyl, Aryl-(C 1 -C 7 )-Alkyl, Heteroaryl-(C 1 -C 7 )-Alkyl, Heterocyclyl-(C 1 -C 7 )-Alkyl, R 32 O-(C 1 -C 7 )-Alkyl, (C 3 -C 7 )-Cycloalkyl-(C 1 -C 7 )-Alkyl, S(O) m R 33 , R 32 (O=)C-(C 1 -C 7 )-Alkyl, C(O=)R 32 , (C 1 -C 7 )-Alkyloxycarbonyl, Aryl-(C 1 -C 7 )-Alkyloxycarbonyl stehen, R 8 und R 9 mit den Stickstoffatomen, an die sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 5 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, R 11 , R 12 , R 13 , R 14 unabhängig voneinander für Wasserstoff, (C 1 -C 7 )-Alkyl, (C2-C 7 )-Alkenyl, (C2-C 7 )- Alkinyl, (C 1 -C 7 )-Haloalkyl, (C 3 -C 7 )-Cycloalkyl, Aryl-(C 1 -C 7 )-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C 1 -C 7 )-Alkyl, Heterocyclyl, Heterocyclyl-(C 1 -C 7 )-Alkyl, R 32 O-(C 1 -C 7 )-Alkyl, R 30 R 31 N-(C 1 -C 7 )-Alkyl, (C3-C 7 )-Cycloalkyl-(C 1 -C 7 )-Alkyl, C(=O)R 32 , C(=O)OR 32 , C(=O)NR 30 R 31 , R 32 O(O)C-(C 1 -C 7 )-Alkyl, R 30 R 31 N(O)C-(C 1 -C 7 )-Alkyl, OR 32 stehen, R 16 , R 17 , R 21 , R 22 unabhängig voneinander für Wasserstoff, (C 1 -C 7 )-Alkyl, (C2-C 7 )-Alkenyl, (C2-C 7 )- Alkinyl, (C 1 -C 7 )-Haloalkyl, (C3-C 7 )-Cycloalkyl, Aryl-(C 1 -C 7 )-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C 1 -C 7 )-Alkyl, Heterocyclyl, Heterocyclyl-(C 1 -C 7 )-Alkyl, R 32 O-(C 1 -C 7 )-Alkyl, R 30 R 31 N-(C 1 -C 7 )-Alkyl, (C 3 -C 7 )-Cycloalkyl-(C 1 -C 7 )-Alkyl, C(=O)R 32 , C(=O)OR 32 , C(=O)NR 30 R 31 stehen, R 23 , R 24 unabhängig voneinander für Wasserstoff, (C 1 -C 8 )-Alkyl, (C 1 -C 7 )-Haloalkyl, (C 3 -C 7 )-Cycloalkyl, Aryl-(C 1 -C 7 )-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C 1 -C 7 )-Alkyl, Heterocyclyl, Heterocyclyl- (C 1 -C 7 )-Alkyl, R 32 O-(C 1 -C 7 )-Alkyl, R 30 R 31 N-(C 1 -C 7 )-Alkyl, (C 3 -C 7 )-Cycloalkyl-(C 1 -C 7 )-Alkyl, C(O=)R 32 , (C 1 -C 7 )-Alkyloxycarbonyl, Aryl-(C 1 -C 7 )-Alkyloxycarbonyl stehen, R 25 , R 28 , R 29 , unabhängig voneinander für Wasserstoff, (C 1 -C 7 )-Alkyl, (C 2 -C 7 )-Alkenyl, (C 2 -C 7 )-Alkinyl, Aryl-(C 1 -C 7 )-Alkyl, Heteroaryl-(C 1 -C 7 )-Alkyl, Heterocyclyl-(C 1 -C 7 )-Alkyl, R 32 O-(C 1 -C 7 )-Alkyl, (C 3 -C 7 )-Cycloalkyl-(C 1 -C 7 )-Alkyl, R 32 (O=)C-(C 1 -C 7 )-Alkyl stehen, R 26 , R 27 unabhängig voneinander für Wasserstoff, (C 1 -C 7 )-Alkyl, (C 1 -C 7 )-Haloalkyl, (C 3 -C 7 )-Cycloalkyl, (C 3 -C 7 )-Cycloalkyl-(C 1 -C 7 )-Alkyl, Aryl-(C 1 -C 7 )-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C 1 -C 7 )- Alkyl, Heterocyclyl, Heterocyclyl-(C 1 -C 7 )-Alkyl stehen, R 30 und R 31 unabhängig voneinander für Wasserstoff, (C 1 -C 7 )-Alkyl, (C 2 -C 7 )-Alkenyl, (C 2 -C 7 )-Alkinyl, (C 1 -C 7 )-Cyanoalkyl, (C 1 -C 7 )-Haloalkyl, (C 2 -C 7 )-Haloalkenyl, (C 3 -C 7 )-Haloalkinyl, (C 3 -C 7 )- Cycloalkyl, (C 3 -C 7 )-Halocycloalkyl, (C 4 -C 7 )-Cycloalkenyl, (C 4 -C 7 )-Halocycloalkenyl, (C 1 -C 7 )- Alkoxy-(C 1 -C 7 )-alkyl, (C 1 -C 7 )-Haloalkoxy-(C 1 -C 7 )-alkyl, (C 1 -C 7 )-Alkylthio-(C 1 -C 7 )-alkyl, (C 1 -C 7 )-Haloalkylthio-(C 1 -C 7 )-alkyl, (C 1 -C 7 )-Alkoxy-(C 1 -C 7 )-haloalkyl, Aryl, Aryl-(C 1 -C 7 )- alkyl, Heteroaryl, Heteroaryl-(C 1 -C 7 )-alkyl, (C 3 -C 7 )-Cycloalkyl-(C 1 -C 7 )-alkyl, (C 4 -C 7 )- Cycloalkenyl-(C 1 -C 7 )-alkyl, COR 32 , SO2R 33 , Heterocyclyl, (C 1 -C 7 )-Alkoxycarbonyl, Bis-[(C 1 - C7)-alkyl]aminocarbonyl-(C 1 -C 7 )-alkyl, (C 1 -C 7 )-Alkyl-aminocarbonyl-(C 1 -C 7 )-alkyl, Aryl-(C 1 - C7)-alkyl-aminocarbonyl-(C 1 -C 7 )-alkyl, Aryl-(C 1 -C 7 )-alkoxycarbonyl, Heteroaryl-(C 1 -C 7 )- alkoxycarbonyl, (C 2 -C 7 )-Alkenyloxycarbonyl, (C 2 -C 7 )-Alkinyloxycarbonyl, Heterocyclyl- (C 1 -C 7 )-alkyl, (C 1 -C 7 )-Alkoxycarbonyl-(C 1 -C 7 )-alkyl, (C 2 -C 7 )-Alkenyloxycarbonyl- (C 1 -C 7 )-alkyl, (C 2 -C 7 )-Alkinyloxycarbonyl-(C 1 -C 7 )-alkyl, Aryl-(C 1 -C 7 )-alkoxycarbonyl- (C 1 -C 7 )-alkyl, Heteroaryl-(C 1 -C 7 )-alkoxycarbonyl-(C 1 -C 7 )-alkyl, Heterocyclyl-(C 1 -C 7 )- alkoxycarbonyl-(C 1 -C 7 )-alkyl stehen, oder R 30 und R 31 mit dem Stickstoffatom, an das sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 3 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, R 32 für Wasserstoff, (C 1 -C 7 )-Alkyl, (C 2 -C 7 )-Alkenyl, (C 2 -C 7 )-Alkinyl, (C 1 -C 7 )-Cyanoalkyl, (C 1 -C 7 )- Haloalkyl, (C 2 -C 7 )-Haloalkenyl, (C 3 -C 7 )-Haloalkinyl, (C 3 -C 7 )-Cycloalkyl, (C 3 -C 7 )- Halocycloalkyl, (C 4 -C 7 )-Cycloalkenyl, (C 4 -C 7 )-Halocycloalkenyl, (C 1 -C 7 )-Alkoxy-(C 1 -C 7 )-alkyl, (C 1 -C 7 )-Haloalkoxy-(C 1 -C 7 )-alkyl, (C 1 -C 7 )-Alkoxy-(C 1 -C 7 )-haloalkyl, (C 1 -C 7 )-Alkoxy-(C 1 -C 7 )- alkoxy-(C 1 -C 7 )-alkyl, (C 1 -C 7 )-Alkoxy-(C 1 -C 7 )-alkoxy-(C 1 -C 7 )-alkoxy-(C 1 -C 7 )-alkyl, (C 1 -C 7 )- Alkoxy-(C 1 -C 7 )-alkoxy-(C 1 -C 7 )-alkoxy-(C 1 -C 7 )-alkoxy-(C 1 -C 7 )-alkyl, Aryl, Aryl-(C 1 -C 7 )-alkyl, Aryl-(C 1 -C 7 )-alkoxy-(C 1 -C 7 )-alkyl, Heteroaryl, Heteroaryl-(C 1 -C 7 )-alkyl, (C 3 -C 7 )-Cycloalkyl- (C 1 -C 7 )-alkyl, (C 4 -C 7 )-Cycloalkenyl-(C 1 -C 7 )-alkyl, Bis-[(C 1 -C 7 )-alkyl]aminocarbonyl-(C 1 -C 7 )- alkyl, (C 1 -C 7 )-Alkyl-aminocarbonyl-(C 1 -C 7 )-alkyl, Aryl-(C 1 -C 7 )-alkyl-aminocarbonyl-(C 1 -C 7 )- alkyl, Bis-[(C 1 -C 7 )-alkyl]amino-(C 2 -C 6 )-alkyl, (C 1 -C 7 )-Alkyl-amino-(C 2 -C 6 )-alkyl, Aryl-(C 1 -C 7 )- alkyl-amino-(C 2 -C 6 )-alkyl, R 33 (O)mS-(C 1 -C 7 )-alkyl, Hydroxycarbonyl-(C 1 -C 7 )-alkyl, Heterocyclyl, Heterocyclyl-(C 1 -C 7 )-alkyl, Tris-[(C 1 -C 7 )-Alkyl]silyl-(C 1 -C 7 )-alkyl, Bis-[(C 1 -C 7 )- Alkyl](aryl)silyl(C 1 -C 7 )-alkyl, [(C 1 -C 7 )-Alkyl]-bis-(aryl)silyl-(C 1 -C 7 )-alkyl, (C 1 -C 7 )- Alkylcarbonyloxy-(C 1 -C 7 )-alkyl, (C 3 -C 7 )-Cycloalkylcarbonyloxy-(C 1 -C 7 )-alkyl, Arylcarbonyloxy-(C 1 -C 7 )-alkyl, Heteroarylcarbonyloxy-(C 1 -C 7 )-alkyl, Heterocyclylcarbonyloxy-(C 1 -C 7 )-alkyl, Aryloxy-(C 1 -C 7 )-alkyl, Heteroaryloxy-(C 1 -C 7 )-alkyl, Heterocyclyloxy-(C 1 -C 7 )-alkyl, (C 1 -C 7 )-Alkoxycarbonyl, (C 1 -C 7 )-Alkoxycarbonyl-(C 1 -C 7 )- alkyl, (C 2 -C 7 )-Alkenyloxycarbonyl-(C 1 -C 7 )-alkyl, (C 2 -C 7 )-Alkinyloxycarbonyl-(C 1 -C 7 )- alkyl, Aryl-(C 1 -C 7 )-alkoxycarbonyl-(C 1 -C 7 )-alkyl, Heteroaryl-(C 1 -C 7 )-alkoxycarbonyl- (C 1 -C 7 )-alkyl, Heterocyclyl-(C 1 -C 7 )-alkoxycarbonyl-(C 1 -C 7 )-alkyl steht, R 33 für Wasserstoff, (C 1 -C 7 )-Alkyl, (C 2 -C 7 )-Alkenyl, (C 2 -C 7 )-Alkinyl, (C 1 -C 7 )-Cyanoalkyl, (C 1 -C 10 )- Haloalkyl, (C 2 -C 7 )-Haloalkenyl, (C 3 -C 7 )-Haloalkinyl, (C 3 -C 10 )-Cycloalkyl, (C 3 -C 10 )- Halocycloalkyl, (C 4 -C 7 )-Cycloalkenyl, (C 4 -C 7 )-Halocycloalkenyl, (C 1 -C 7 )-Alkoxy-(C 1 -C 7 )-alkyl, (C 1 -C 7 )-Alkoxy-(C 1 -C 7 )-haloalkyl, Aryl, Aryl-(C 1 -C 7 )-alkyl, Heteroaryl, Heteroaryl-(C 1 -C 7 )- alkyl, Heterocyclyl-(C 1 -C 7 )-alkyl, (C 3 -C 7 )-Cycloalkyl-(C 1 -C 7 )-alkyl, (C 4 -C 10 )-Cycloalkenyl- (C 1 -C 7 )-alkyl, Bis-[(C 1 -C 7 )-alkyl]amino, (C 1 -C 7 )-Alkyl-amino, Aryl-(C 1 -C 7 )-amino, Aryl-(C 1 - C 6 )-alkyl-amino, Aryl-[(C 1 -C 7 )-alkyl]amino; Heteroaryl-(C 1 -C 7 )-amino, Heteroaryl-(C 1 -C 6 )- alkyl-amino, Heteroaryl-[(C 1 -C 7 )-alkyl]amino; Hetercyclyl-(C 1 -C 7 )-amino, Heterocyclyl-(C 1 - C 6 )-alkyl-amino, Heterocyclyl-[(C 1 -C 7 )-alkyl]amino; (C 3 -C 7 )-Cycloalkyl-amino, (C 3 -C 7 )- Cycloalkyl-[(C 1 -C 7 )-alkyl]amino; N-Azetidinyl, N-Pyrrolidinyl, N-Piperidinyl. N-Morpholinyl steht, R 34 für Wasserstoff, (C 1 -C 7 )-Alkyl, (C 2 -C 7 )-Alkenyl, Aryl-(C 1 -C 7 )-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C 1 -C 7 )-Alkyl, Heterocyclyl, Heterocyclyl-(C 1 -C 7 )-Alkyl, R 32 O-(C 1 -C 7 )-Alkyl, R 30 R 31 N-(C 1 -C 7 )-Alkyl, NR 30 R 31 , (C 3 -C 7 )-Cycloalkyl-(C 1 -C 7 )-Alkyl, S(O) m R 33 steht, R 35 für Wasserstoff, NR 30 R 31 , OR 32 , (C 1 -C 7 )-Alkyl, (C 2 -C 7 )-Alkenyl, (C 2 -C 7 )-Alkinyl, Aryl, Aryl- (C 1 -C 7 )-Alkyl, Heteroaryl, Heteroaryl-(C 1 -C 7 )-Alkyl, Heterocyclyl, Heterocyclyl-(C 1 -C 7 )-Alkyl, R 32 O-(C 1 -C 7 )-Alkyl, (C 3 -C 7 )-Cycloalkyl, (C 3 -C 7 )-Cycloalkyl-(C 1 -C 7 )-Alkyl, S(O) m R 33 , R 32 (O=)C-(C 1 -C 7 )-Alkyl, R 32 O(O)C-(C 1 -C 7 )-Alkyl, R 30 R 31 N(O)C-(C 1 -C 7 )-Alkyl, R 33 S(O) m - (C 1 -C 7 )-alkyl, R 32 O-(C 1 -C 7 )-Alkyl, R 30 R 31 N-(C 1 -C 7 )-Alkyl steht, R 36 für Wasserstoff, (C 1 -C 7 )-Alkyl, (C 2 -C 7 )-Alkenyl, (C 2 -C 7 )-Alkinyl, Aryl, Aryl-(C 1 -C 7 )-Alkyl, Heteroaryl, Heteroaryl-(C 1 -C 7 )-Alkyl, Heterocyclyl, Heterocyclyl-(C 1 -C 7 )-Alkyl, (C 3 -C 10 )- Cycloalkyl, (C 3 -C 7 )-Cycloalkyl-(C 1 -C 7 )-Alkyl, R 32 (O=)C-(C 1 -C 7 )-Alkyl, R 32 O(O)C-(C 1 -C 7 )- Alkyl, R 30 R 31 N(O)C-(C 1 -C 7 )-Alkyl, R 33 S(O)m-(C 1 -C 7 )-alkyl, R 32 O-(C 1 -C 7 )-Alkyl, R 30 R 31 N- (C 1 -C 7 )-Alkyl steht, R 37 für (C 1 -C 7 )-Alkyl, (C 2 -C 7 )-Alkenyl, (C 2 -C 7 )-Alkinyl, (C 1 -C 7 )-Haloalkyl, (C 2 -C 7 )-Haloalkenyl, (C 2 -C 7 )-Haloalkinyl, (C 3 -C 7 )-Cycloalkyl, (C 3 -C 7 )-Halocycloalkyl, (C 4 -C 7 )-Cycloalkenyl, (C 4 -C 7 )-Halocycloalkenyl, Aryl, Aryl-(C 1 -C 7 )-Alkyl, Heteroaryl, Heteroaryl-(C 1 -C 7 )-Alkyl, Heterocyclyl, Heterocyclyl-(C 1 -C 7 )-Alkyl, Heteroaryloxy-(C 1 -C 7 )-Alkyl, Aryloxy-(C 1 -C 7 )- Alkyl, Heterocyclyloxy-(C 1 -C 7 )-Alkyl, R 32 O-(C 1 -C 7 )-Alkyl, R 30 R 31 N-(C 1 -C 7 )-Alkyl, R 32 O(O)C- (C 1 -C 7 )-Alkyl, R 30 R 31 N(O)C-(C 1 -C 7 )-Alkyl, (C 3 -C 7 )-Cycloalkyl-(C 1 -C 7 )-Alkyl, R 33 S(O)m- (C 1 -C 7 )-alkyl, R 32 (O=)C-(C 1 -C 7 )-Alkyl steht und R 38 für (C 1 -C 8 )-Alkyl, (C 2 -C 8 )-Alkenyl, (C 2 -C 8 )-Alkinyl, Aryl, Aryl-(C 1 -C 8 )-Alkyl, Heteroaryl, Heteroaryl-(C 1 -C 8 )-Alkyl, Heterocyclyl, Heterocyclyl-(C 1 -C 8 )-Alkyl, (C 3 -C 10 )-Cycloalkyl, (C 3 -C 10 )-Cycloalkyl-(C 1 -C 8 )-Alkyl, R 32 (O=)C-(C 1 -C 8 )-Alkyl, R 32 O(O)C-(C 1 -C 8 )-Alkyl, R 30 R 31 N(O)C-(C 1 -C 8 )-Alkyl, R 33 S(O)m-(C 1 -C 8 )-alkyl, R 32 O-(C 1 -C 8 )-Alkyl, R 30 R 31 N-(C 1 -C 8 )- Alkyl steht. Besonders bevorzugter Erfindungsgegenstand ist die Verwendung von Verbindungen der allgemeinen Formel (I), worin R 1 für Wasserstoff, NR 30 R 31 , OR 32 , S(O) m R 33 , (C 1 -C 6 )-Alkyl, (C 2 -C 6 )-Alkenyl, (C 2 -C 6 )-Alkinyl, (C 1 -C 6 )-Haloalkyl, (C 2 -C 6 )-Haloalkenyl, (C 2 -C 6 )-Haloalkinyl, (C 3 -C 6 )-Cycloalkyl, (C 3 -C 6 )- Halocycloalkyl, (C 4 -C 6 )-Cycloalkenyl, (C 4 -C 6 )-Halocycloalkenyl, Aryl, Aryl-(C 1 -C 6 )-Alkyl, Heteroaryl, Heteroaryl-(C 1 -C 6 )-Alkyl, Heterocyclyl, Heterocyclyl-(C 1 -C 6 )-Alkyl, R 32 O-(C 1 -C 6 )- Alkyl, R 30 R 31 N-(C 1 -C 6 )-Alkyl, R 32 O(O)C-(C 1 -C 6 )-Alkyl, R 30 R 31 N(O)C-(C 1 -C 6 )-Alkyl, (C 3 -C 10 )- Cycloalkyl-(C 1 -C 6 )-Alkyl, R 33 S(O) m -(C 1 -C 6 )-alkyl, R 32 (O=)C-(C 1 -C 6 )-Alkyl, C(=O)R 32 , C(=O)OR 32 steht, m für 0, 1, 2 steht, R 3 und R 4 unabhängig voneinander für Wasserstoff, (C 1 -C 6 )-Alkyl, (C 2 -C 6 )-Alkenyl, (C 1 -C 10 )-Haloalkyl, (C 3 -C 6 )-Cycloalkyl, (C 3 -C 6 )-Cycloalkyl-(C 1 -C 6 )-Alkyl, Aryl-(C 1 -C 6 )-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C 1 -C 6 )-Alkyl, Heterocyclyl, Heterocyclyl-(C 1 -C 6 )-Alkyl, R 32 O-(C 1 -C 6 )-Alkyl, R 30 R 31 N-(C 1 -C 6 )-Alkyl stehen, R 5 , R 6 unabhängig voneinander für Wasserstoff, (C 1 -C 6 )-Alkyl, (C 2 -C 6 )-Alkenyl, (C 1 -C 6 )-Haloalkyl, (C 3 -C 6 )-Cycloalkyl, Aryl-(C 1 -C 6 )-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C 1 -C 6 )-Alkyl, Heterocyclyl, Heterocyclyl-(C 1 -C 6 )-Alkyl, R 32 O-(C 1 -C 6 )-Alkyl, R 30 R 31 N-(C 1 -C 6 )-Alkyl, NR 30 R 31 , OR 32 , (C 3 -C 6 )-Cycloalkyl-(C 1 -C 6 )-Alkyl stehen, R 3 und R 5 mit den Kohlenstoffatomen, an die sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 5 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, R 2 für Wasserstoff und eine der nachfolgenden Gruppen G-1 bis G-2 steht, wobei ein Pfeil für eine Bindung zum Pyrrolidinonring in der allgemeinen Formel (I) steht, R 7 für Wasserstoff und eine der nachfolgenden Gruppen G-1 bis G-15 steht, wobei ein Pfeil für eine Bindung zum Pyrrolidinonring in der allgemeinen Formel (I) steht, mit der Maßgabe, dass R 2 und R 7 nicht gleichzeitig H sind und dass R 7 für H steht, wenn R 2 für eine der nachfolgenden Gruppen G-1 bis G-2 steht, und dass R 2 für H steht, wenn R 7 für eine der nachfolgenden Gruppen G-1 bis G-15 steht,

' R 8 , R 9 , R 10 , R 15 , R 18 , R 19 , R 20 unabhängig voneinander für Wasserstoff, (C 1 -C 6 )-Alkyl, (C 2 -C 6 )-Alkenyl, (C 2 -C 6 )-Alkinyl, Aryl-(C 1 -C 6 )-Alkyl, Heteroaryl-(C 1 -C 6 )-Alkyl, Heterocyclyl-(C 1 -C 6 )-Alkyl, R 32 O-(C 1 -C 6 )-Alkyl, (C 3 -C 6 )-Cycloalkyl-(C 1 -C 6 )-Alkyl, S(O) m R 33 , R 32 (O=)C-(C 1 -C 6 )-Alkyl, C(O=)R 32 , (C 1 -C 6 )-Alkyloxycarbonyl, Aryl-(C 1 -C 6 )-Alkyloxycarbonyl stehen, R 8 und R 9 mit den Stickstoffatomen, an die sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 5 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, R 11 , R 12 , R 13 , R 14 unabhängig voneinander für Wasserstoff, (C 1 -C 6 )-Alkyl, (C 2 -C 6 )-Alkenyl, (C 2 -C 6 )- Alkinyl, (C 1 -C 6 )-Haloalkyl, (C 3 -C 6 )-Cycloalkyl, Aryl-(C 1 -C 6 )-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C 1 -C 6 )-Alkyl, Heterocyclyl, Heterocyclyl-(C 1 -C 6 )-Alkyl, R 32 O-(C 1 -C 6 )-Alkyl, R 30 R 31 N-(C 1 -C 6 )-Alkyl, (C 3 -C 6 )-Cycloalkyl-(C 1 -C 6 )-Alkyl, C(=O)R 32 , C(=O)OR 32 , C(=O)NR 30 R 31 , R 32 O(O)C-(C 1 -C 6 )-Alkyl, R 30 R 31 N(O)C-(C 1 -C 6 )-Alkyl, OR 32 stehen, R 16 , R 17 , R 21 , R 22 unabhängig voneinander für Wasserstoff, (C 1 -C 6 )-Alkyl, (C 2 -C 6 )-Alkenyl, (C 2 -C 6 )- Alkinyl, (C 1 -C 6 )-Haloalkyl, (C 3 -C 6 )-Cycloalkyl, Aryl-(C 1 -C 6 )-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C 1 -C 6 )-Alkyl, Heterocyclyl, Heterocyclyl-(C 1 -C 6 )-Alkyl, R 32 O-(C 1 -C 6 )-Alkyl, R 30 R 31 N-(C 1 -C 6 )-Alkyl, (C 3 -C 6 )-Cycloalkyl-(C 1 -C 6 )-Alkyl, C(=O)R 32 , C(=O)OR 32 , C(=O)NR 30 R 31 stehen, R 23 , R 24 unabhängig voneinander für Wasserstoff, (C 1 -C 6 )-Alkyl, (C 1 -C 6 )-Haloalkyl, (C 3 -C 6 )-Cycloalkyl, Aryl-(C 1 -C 6 )-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C 1 -C 6 )-Alkyl, Heterocyclyl, Heterocyclyl- (C 1 -C 6 )-Alkyl, R 32 O-(C 1 -C 6 )-Alkyl, R 30 R 31 N-(C 1 -C 6 )-Alkyl, (C 3 -C 6 )-Cycloalkyl-(C 1 -C 6 )-Alkyl, C(O=)R 32 , (C 1 -C 6 )-Alkyloxycarbonyl, Aryl-(C 1 -C 6 )-Alkyloxycarbonyl stehen, R 25 , R 28 , R 29 unabhängig voneinander für Wasserstoff, (C 1 -C 6 )-Alkyl, (C 2 -C 6 )-Alkenyl, (C 2 -C 6 )-Alkinyl, Aryl-(C 1 -C 6 )-Alkyl, Heteroaryl-(C 1 -C 6 )-Alkyl, Heterocyclyl-(C 1 -C 6 )-Alkyl, R 32 O-(C 1 -C 6 )-Alkyl, (C 3 -C 6 )-Cycloalkyl-(C 1 -C 6 )-Alkyl, R 32 (O=)C-(C 1 -C 6 )-Alkyl stehen, R 26 , R 27 unabhängig voneinander für Wasserstoff, (C 1 -C 6 )-Alkyl, (C 1 -C 6 )-Haloalkyl, (C 3 -C 6 )-Cycloalkyl, (C 3 -C 6 )-Cycloalkyl-(C 1 -C 6 )-Alkyl, Aryl-(C 1 -C 6 )-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C 1 -C 6 )- Alkyl, Heterocyclyl, Heterocyclyl-(C 1 -C 6 )-Alkyl stehen, R 30 und R 31 unabhängig voneinander für Wasserstoff, (C 1 -C 6 )-Alkyl, (C 2 -C 6 )-Alkenyl, (C 2 -C 6 )-Alkinyl, (C 1 -C 6 )-Cyanoalkyl, (C 1 -C 6 )-Haloalkyl, (C 2 -C 6 )-Haloalkenyl, (C 3 -C 6 )-Haloalkinyl, (C 3 -C 6 )- Cycloalkyl, (C 3 -C 6 )-Halocycloalkyl, (C 4 -C 6 )-Cycloalkenyl, (C 4 -C 6 )-Halocycloalkenyl, (C 1 -C 6 )- Alkoxy-(C 1 -C 6 )-alkyl, (C 1 -C 6 )-Haloalkoxy-(C 1 -C 6 )-alkyl, (C 1 -C 6 )-Alkylthio-(C 1 -C 6 )-alkyl, (C 1 -C 6 )-Haloalkylthio-(C 1 -C 6 )-alkyl, (C 1 -C 6 )-Alkoxy-(C 1 -C 6 )-haloalkyl, Aryl, Aryl-(C 1 -C 6 )- alkyl, Heteroaryl, Heteroaryl-(C 1 -C 6 )-alkyl, (C 3 -C 6 )-Cycloalkyl-(C 1 -C 6 )-alkyl, (C 4 -C 6 )- Cycloalkenyl-(C 1 -C 6 )-alkyl, COR 32 , SO2R 33 , Heterocyclyl, (C 1 -C 6 )-Alkoxycarbonyl, Bis-[(C 1 - C 6 )-alkyl]aminocarbonyl-(C 1 -C 6 )-alkyl, (C 1 -C 6 )-Alkyl-aminocarbonyl-(C 1 -C 6 )-alkyl, Aryl-(C 1 - C 6 )-alkyl-aminocarbonyl-(C 1 -C 6 )-alkyl, Aryl-(C 1 -C 6 )-alkoxycarbonyl, Heteroaryl-(C 1 -C 6 )- alkoxycarbonyl, (C 2 -C 6 )-Alkenyloxycarbonyl, (C 2 -C 6 )-Alkinyloxycarbonyl, Heterocyclyl- (C 1 -C 6 )-alkyl, (C 1 -C 6 )-Alkoxycarbonyl-(C 1 -C 6 )-alkyl, (C 2 -C 6 )-Alkenyloxycarbonyl- (C 1 -C 6 )-alkyl, (C 2 -C 6 )-Alkinyloxycarbonyl-(C 1 -C 6 )-alkyl, Aryl-(C 1 -C 6 )-alkoxycarbonyl- (C 1 -C 6 )-alkyl, Heteroaryl-(C 1 -C 6 )-alkoxycarbonyl-(C 1 -C 6 )-alkyl, Heterocyclyl-(C 1 -C 6 )- alkoxycarbonyl-(C 1 -C 6 )-alkyl stehen, oder R 30 und R 31 mit dem Stickstoffatom, an das sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 3 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, R 32 für Wasserstoff, (C 1 -C 6 )-Alkyl, (C 2 -C 6 )-Alkenyl, (C 2 -C 6 )-Alkinyl, (C 1 -C 6 )-Cyanoalkyl, (C 1 -C 6 )- Haloalkyl, (C 2 -C 6 )-Haloalkenyl, (C 3 -C 6 )-Haloalkinyl, (C 3 -C 6 )-Cycloalkyl, (C 3 -C 6 )- Halocycloalkyl, (C 4 -C 6 )-Cycloalkenyl, (C 4 -C 6 )-Halocycloalkenyl, (C 1 -C 6 )-Alkoxy-(C 1 -C 6 )-alkyl, (C 1 -C 6 )-Haloalkoxy-(C 1 -C 6 )-alkyl, (C 1 -C 6 )-Alkoxy-(C 1 -C 6 )-haloalkyl, (C 1 -C 6 )-Alkoxy-(C 1 -C 6 )- alkoxy-(C 1 -C 6 )-alkyl, (C 1 -C 6 )-Alkoxy-(C 1 -C 6 )-alkoxy-(C 1 -C 6 )-alkoxy-(C 1 -C 6 )-alkyl, (C 1 -C 6 )- Alkoxy-(C 1 -C 6 )-alkoxy-(C 1 -C 6 )-alkoxy-(C 1 -C 6 )-alkoxy-(C 1 -C 6 )-alkyl, Aryl, Aryl-(C 1 -C 6 )-alkyl, Aryl-(C 1 -C 6 )-alkoxy-(C 1 -C 6 )-alkyl, Heteroaryl, Heteroaryl-(C 1 -C 6 )-alkyl, (C 3 -C 6 )-Cycloalkyl- (C 1 -C 6 )-alkyl, (C 4 -C 6 )-Cycloalkenyl-(C 1 -C 6 )-alkyl, Bis-[(C 1 -C 6 )-alkyl]aminocarbonyl-(C 1 -C 6 )- alkyl, (C 1 -C 6 )-Alkyl-aminocarbonyl-(C 1 -C 6 )-alkyl, Aryl-(C 1 -C 6 )-alkyl-aminocarbonyl-(C 1 -C 6 )- alkyl, Bis-[(C 1 -C 6 )-alkyl]amino-(C 2 -C 6 )-alkyl, (C 1 -C 6 )-Alkyl-amino-(C 2 -C 6 )-alkyl, Aryl-(C 1 -C 6 )- alkyl-amino-(C 2 -C 6 )-alkyl, R 33 (O)mS-(C 1 -C 6 )-alkyl, Hydroxycarbonyl-(C 1 -C 6 )-alkyl, Heterocyclyl, Heterocyclyl-(C 1 -C 6 )-alkyl, Tris-[(C 1 -C 6 )-Alkyl]silyl-(C 1 -C 6 )-alkyl, Bis-[(C 1 -C 6 )- Alkyl](aryl)silyl(C 1 -C 6 )-alkyl, [(C 1 -C 6 )-Alkyl]-bis-(aryl)silyl-(C 1 -C 6 )-alkyl, (C 1 -C 6 )- Alkylcarbonyloxy-(C 1 -C 6 )-alkyl, (C 3 -C 6 )-Cycloalkylcarbonyloxy-(C 1 -C 6 )-alkyl, Arylcarbonyloxy-(C 1 -C 6 )-alkyl, Heteroarylcarbonyloxy-(C 1 -C 6 )-alkyl, Heterocyclylcarbonyloxy-(C 1 -C 6 )-alkyl, Aryloxy-(C 1 -C 6 )-alkyl, Heteroaryloxy-(C 1 -C 6 )-alkyl, Heterocyclyloxy-(C 1 -C 6 )-alkyl, (C 1 -C 6 )-Alkoxycarbonyl, (C 1 -C 6 )-Alkoxycarbonyl-(C 1 -C 6 )- alkyl, (C 2 -C 6 )-Alkenyloxycarbonyl-(C 1 -C 6 )-alkyl, (C 2 -C 6 )-Alkinyloxycarbonyl-(C 1 -C 6 )- alkyl, Aryl-(C 1 -C 6 )-alkoxycarbonyl-(C 1 -C 6 )-alkyl, Heteroaryl-(C 1 -C 6 )-alkoxycarbonyl- (C 1 -C 6 )-alkyl, Heterocyclyl-(C 1 -C 6 )-alkoxycarbonyl-(C 1 -C 6 )-alkyl steht, R 33 für Wasserstoff, (C 1 -C 6 )-Alkyl, (C 2 -C 6 )-Alkenyl, (C 2 -C 6 )-Alkinyl, (C 1 -C 6 )-Cyanoalkyl, (C 1 -C 6 )- Haloalkyl, (C 2 -C 6 )-Haloalkenyl, (C 3 -C 6 )-Haloalkinyl, (C 3 -C 10 )-Cycloalkyl, (C 3 -C 10 )- Halocycloalkyl, (C 4 -C 6 )-Cycloalkenyl, (C 4 -C 6 )-Halocycloalkenyl, (C 1 -C 6 )-Alkoxy-(C 1 -C 6 )-alkyl, (C 1 -C 6 )-Alkoxy-(C 1 -C 6 )-haloalkyl, Aryl, Aryl-(C 1 -C 6 )-alkyl, Heteroaryl, Heteroaryl-(C 1 -C 6 )- alkyl, Heterocyclyl-(C 1 -C 6 )-alkyl, (C 3 -C 6 )-Cycloalkyl-(C 1 -C 6 )-alkyl, (C 4 -C 10 )-Cycloalkenyl- (C 1 -C 6 )-alkyl, Bis-[(C 1 -C 6 )-alkyl]amino, (C 1 -C 6 )-Alkyl-amino, Aryl-(C 1 -C 6 )-amino, Aryl-(C 1 - C 6 )-alkyl-amino, Aryl-[(C 1 -C 6 )-alkyl]amino; Heteroaryl-(C 1 -C 6 )-amino, Heteroaryl-(C 1 -C 6 )- alkyl-amino, Heteroaryl-[(C 1 -C 6 )-alkyl]amino; Hetercyclyl-(C 1 -C 6 )-amino, Heterocyclyl-(C 1 - C 6 )-alkyl-amino, Heterocyclyl-[(C 1 -C 6 )-alkyl]amino; (C 3 -C 6 )-Cycloalkyl-amino, (C 3 -C 6 )- Cycloalkyl-[(C 1 -C 6 )-alkyl]amino; N-Azetidinyl, N-Pyrrolidinyl, N-Piperidinyl. N-Morpholinyl steht, R 34 für Wasserstoff, (C 1 -C 6 )-Alkyl, (C 2 -C 6 )-Alkenyl, Aryl-(C 1 -C 6 )-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C 1 -C 6 )-Alkyl, Heterocyclyl, Heterocyclyl-(C 1 -C 6 )-Alkyl, R 32 O-(C 1 -C 6 )-Alkyl, R 30 R 31 N-(C 1 -C 6 )-Alkyl, NR 30 R 31 , (C 3 -C 6 )-Cycloalkyl-(C 1 -C 6 )-Alkyl, S(O) m R 33 steht, R 35 für Wasserstoff, NR 30 R 31 , OR 32 , (C 1 -C 6 )-Alkyl, (C 2 -C 6 )-Alkenyl, (C 2 -C 6 )-Alkinyl, Aryl, Aryl- (C 1 -C 6 )-Alkyl, Heteroaryl, Heteroaryl-(C 1 -C 6 )-Alkyl, Heterocyclyl, Heterocyclyl-(C 1 -C 6 )-Alkyl, R 32 O-(C 1 -C 6 )-Alkyl, (C 3 -C 6 )-Cycloalkyl, (C 3 -C 6 )-Cycloalkyl-(C 1 -C 6 )-Alkyl, S(O) m R 33 , R 32 (O=)C-(C 1 -C 6 )-Alkyl, R 32 O(O)C-(C 1 -C 6 )-Alkyl, R 30 R 31 N(O)C-(C 1 -C 6 )-Alkyl, R 33 S(O) m - (C 1 -C 6 )-alkyl, R 32 O-(C 1 -C 6 )-Alkyl, R 30 R 31 N-(C 1 -C 6 )-Alkyl steht, R 36 für Wasserstoff, (C 1 -C 6 )-Alkyl, (C 2 -C 6 )-Alkenyl, (C 2 -C 6 )-Alkinyl, Aryl, Aryl-(C 1 -C 6 )-Alkyl, Heteroaryl, Heteroaryl-(C 1 -C 6 )-Alkyl, Heterocyclyl, Heterocyclyl-(C 1 -C 6 )-Alkyl, (C 3 -C 10 )- Cycloalkyl, (C 3 -C 6 )-Cycloalkyl-(C 1 -C 6 )-Alkyl, R 32 (O=)C-(C 1 -C 6 )-Alkyl, R 32 O(O)C-(C 1 -C 6 )- Alkyl, R 30 R 31 N(O)C-(C 1 -C 6 )-Alkyl, R 33 S(O)m-(C 1 -C 6 )-alkyl, R 32 O-(C 1 -C 6 )-Alkyl, R 30 R 31 N- (C 1 -C 6 )-Alkyl steht, R 37 für (C 1 -C 6 )-Alkyl, (C 2 -C 6 )-Alkenyl, (C 2 -C 6 )-Alkinyl, (C 1 -C 6 )-Haloalkyl, (C 2 -C 6 )-Haloalkenyl, (C 2 -C 6 )-Haloalkinyl, (C 3 -C 6 )-Cycloalkyl, (C 3 -C 6 )-Halocycloalkyl, (C 4 -C 6 )-Cycloalkenyl, (C 4 -C 6 )-Halocycloalkenyl, Aryl, Aryl-(C 1 -C 6 )-Alkyl, Heteroaryl, Heteroaryl-(C 1 -C 6 )-Alkyl, Heterocyclyl, Heterocyclyl-(C 1 -C 6 )-Alkyl, Heteroaryloxy-(C 1 -C 6 )-Alkyl, Aryloxy-(C 1 -C 6 )- Alkyl, Heterocyclyloxy-(C 1 -C 6 )-Alkyl, R 32 O-(C 1 -C 6 )-Alkyl, R 30 R 31 N-(C 1 -C 6 )-Alkyl, R 32 O(O)C- (C 1 -C 6 )-Alkyl, R 30 R 31 N(O)C-(C 1 -C 6 )-Alkyl, (C 3 -C 6 )-Cycloalkyl-(C 1 -C 6 )-Alkyl, R 33 S(O)m- (C 1 -C 6 )-alkyl, R 32 (O=)C-(C 1 -C 6 )-Alkyl steht und R 38 für (C 1 -C 8 )-Alkyl, (C 2 -C 8 )-Alkenyl, (C 2 -C 8 )-Alkinyl, Aryl, Aryl-(C 1 -C 8 )-Alkyl, Heteroaryl, Heteroaryl-(C 1 -C 8 )-Alkyl, Heterocyclyl, Heterocyclyl-(C 1 -C 8 )-Alkyl, (C 3 -C 10 )-Cycloalkyl, (C 3 -C 10 )-Cycloalkyl-(C 1 -C 8 )-Alkyl, R 32 (O=)C-(C 1 -C 8 )-Alkyl, R 32 O(O)C-(C 1 -C 8 )-Alkyl, R 30 R 31 N(O)C-(C 1 -C 8 )-Alkyl, R 33 S(O)m-(C 1 -C 8 )-alkyl, R 32 O-(C 1 -C 8 )-Alkyl, R 30 R 31 N-(C 1 -C 8 )- Alkyl steht. Ganz besonders bevorzugter Erfindungsgegenstand ist die Verwendung von Verbindungen der allgemeinen Formel (I), worin R 1 für Wasserstoff, NR 30 R 31 , OR 32 , S(O) m R 33 , (C 1 -C 6 )-Alkyl, (C 2 -C 6 )-Alkenyl, (C 2 -C 6 )-Alkinyl, (C 1 -C 6 )-Haloalkyl, (C 2 -C 6 )-Haloalkenyl, (C 2 -C 6 )-Haloalkinyl, (C 3 -C 6 )-Cycloalkyl, (C 3 -C 6 )- Halocycloalkyl, (C 4 -C 6 )-Cycloalkenyl, (C 4 -C 6 )-Halocycloalkenyl, Aryl, Aryl-(C 1 -C 6 )-Alkyl, Heteroaryl, Heteroaryl-(C 1 -C 6 )-Alkyl, Heterocyclyl, Heterocyclyl-(C 1 -C 6 )-Alkyl, R 32 O-(C 1 -C 6 )- Alkyl, R 30 R 31 N-(C 1 -C 6 )-Alkyl, R 32 O(O)C-(C 1 -C 6 )-Alkyl, R 30 R 31 N(O)C-(C 1 -C 6 )-Alkyl, (C 3 -C 10 )- Cycloalkyl-(C 1 -C 6 )-Alkyl, R 33 S(O) m -(C 1 -C 6 )-alkyl, R 32 (O=)C-(C 1 -C 6 )-Alkyl, C(=O)R 32 , C(=O)OR 32 steht, m für 0, 1, 2 steht, R 3 und R 4 unabhängig voneinander für Wasserstoff, Methyl, Ethyl, Prop-1-yl, 1-Methyleth-1-yl, Vinyl, 1-Methyleth-1-en-1.yl, prop-2-en-1-yl, Difluormethyl, Trifluormethyl, Cyclopropyl, Cyclobutyl, Cyclopropylmethyl, Cyclobutylmethyl, Cyclopentylmethyl, Cyclohexylmethyl, Phenyl, Benzyl, Methoxymethyl, Ethoxymethyl, Methoxyethyl, Ethoxyethyl stehen, R 5 , R 6 unabhängig voneinander für Wasserstoff, Methyl, Ethyl, Prop-1-yl, 1-Methyleth-1-yl, Vinyl, prop-2-en-1-yl, Difluormethyl, Trifluormethyl, Cyclopropyl, Cyclobutyl, Cyclopropylmethyl, Cyclobutylmethyl, Cyclopentylmethyl, Cyclohexylmethyl, Phenyl, 4-Fluorphenyl, 3- Fluorphenyl, 2-Fluorphenyl, 4-Chlorphenyl, 3-Chlorphenyl, 2-Chlorphenyl, Benzyl, 4- Fluorbenzyl, 3-Fluorbenzyl, 2-Fluorbenzyl, Pyridin-2-ylmethyl, Pyridin-3-ylmethyl, Pyridin-4- ylmethyl, Methoxymethyl, Ethoxymethyl, Methoxyethyl, Ethoxyethyl, Heterocyclyl, Hydroxy, Methoxy, Ethoxy, Methylcarbonyloxy, Ethylcarbonyloxy, 1-Methyleth-1-ylcarbonyloxy, 1,1- Dimethyleth-1-ylcarbonyloxy stehen, R 3 und R 5 mit den Kohlenstoffatomen, an die sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 5 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, R 2 für Wasserstoff und eine der nachfolgenden Gruppen G-1 bis G-2 steht, wobei ein Pfeil für eine Bindung zum Pyrrolidinonring in der allgemeinen Formel (I) steht, R 7 für Wasserstoff und eine der nachfolgenden Gruppen G-1 bis G-15 steht, wobei ein Pfeil für eine Bindung zum Pyrrolidinonring in der allgemeinen Formel (I) steht, mit der Maßgabe, dass R 2 und R 7 nicht gleichzeitig H sind und dass R 7 für H steht, wenn R 2 für eine der nachfolgenden Gruppen G-1 bis G-2 steht, und dass R 2 für H steht, wenn R 7 für eine der nachfolgenden Gruppen G-1 bis G-15 steht, ' R 8 , R 9 , R 10 , R 15 , R 18 , R 19 , R 20 unabhängig voneinander für Wasserstoff, (C 1 -C 6 )-Alkyl, (C 2 -C 6 )-Alkenyl, (C 2 -C 6 )-Alkinyl, Aryl-(C 1 -C 6 )-Alkyl, Heteroaryl-(C 1 -C 6 )-Alkyl, Heterocyclyl-(C 1 -C 6 )-Alkyl, R 32 O-(C 1 -C 6 )-Alkyl, (C 3 -C 6 )-Cycloalkyl-(C 1 -C 6 )-Alkyl, S(O) m R 33 , R 32 (O=)C-(C 1 -C 6 )-Alkyl, C(O=)R 32 , (C 1 -C 6 )-Alkyloxycarbonyl, Aryl-(C 1 -C 6 )-Alkyloxycarbonyl stehen, R 8 und R 9 mit den Stickstoffatomen, an die sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 5 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, R 11 , R 12 , R 13 , R 14 unabhängig voneinander für Wasserstoff, (C 1 -C 6 )-Alkyl, (C 2 -C 6 )-Alkenyl, (C 2 -C 6 )- Alkinyl, (C 1 -C 6 )-Haloalkyl, (C 3 -C 6 )-Cycloalkyl, Aryl-(C 1 -C 6 )-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C 1 -C 6 )-Alkyl, Heterocyclyl, Heterocyclyl-(C 1 -C 6 )-Alkyl, R 32 O-(C 1 -C 6 )-Alkyl, R 30 R 31 N-(C 1 -C 6 )-Alkyl, (C 3 -C 6 )-Cycloalkyl-(C 1 -C 6 )-Alkyl, C(=O)R 32 , C(=O)OR 32 , C(=O)NR 30 R 31 , R 32 O(O)C-(C 1 -C 6 )-Alkyl, R 30 R 31 N(O)C-(C 1 -C 6 )-Alkyl, OR 32 stehen, R 16 , R 17 , R 21 , R 22 unabhängig voneinander für Wasserstoff, (C 1 -C 6 )-Alkyl, (C 2 -C 6 )-Alkenyl, (C 2 -C 6 )- Alkinyl, (C 1 -C 6 )-Haloalkyl, (C 3 -C 6 )-Cycloalkyl, Aryl-(C 1 -C 6 )-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C 1 -C 6 )-Alkyl, Heterocyclyl, Heterocyclyl-(C 1 -C 6 )-Alkyl, R 32 O-(C 1 -C 6 )-Alkyl, R 30 R 31 N-(C 1 -C 6 )-Alkyl, (C 3 -C 6 )-Cycloalkyl-(C 1 -C 6 )-Alkyl, C(=O)R 32 , C(=O)OR 32 , C(=O)NR 30 R 31 stehen, R 23 , R 24 unabhängig voneinander für Wasserstoff, (C 1 -C 6 )-Alkyl, (C 1 -C 6 )-Haloalkyl, (C 3 -C 6 )-Cycloalkyl, Aryl-(C 1 -C 6 )-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C 1 -C 6 )-Alkyl, Heterocyclyl, Heterocyclyl- (C 1 -C 6 )-Alkyl, R 32 O-(C 1 -C 6 )-Alkyl, R 30 R 31 N-(C 1 -C 6 )-Alkyl, (C 3 -C 6 )-Cycloalkyl-(C 1 -C 6 )-Alkyl, C(O=)R 32 , (C 1 -C 6 )-Alkyloxycarbonyl, Aryl-(C 1 -C 6 )-Alkyloxycarbonyl stehen, R 25 , R 28 , R 29 unabhängig voneinander für Wasserstoff, (C 1 -C 6 )-Alkyl, (C 2 -C 6 )-Alkenyl, (C 2 -C 6 )-Alkinyl, Aryl-(C 1 -C 6 )-Alkyl, Heteroaryl-(C 1 -C 6 )-Alkyl, Heterocyclyl-(C 1 -C 6 )-Alkyl, R 32 O-(C 1 -C 6 )-Alkyl, (C 3 -C 6 )-Cycloalkyl-(C 1 -C 6 )-Alkyl, R 32 (O=)C-(C 1 -C 6 )-Alkyl stehen, R 26 , R 27 unabhängig voneinander für Wasserstoff, (C 1 -C 6 )-Alkyl, (C 1 -C 6 )-Haloalkyl, (C 3 -C 6 )-Cycloalkyl, (C 3 -C 6 )-Cycloalkyl-(C 1 -C 6 )-Alkyl, Aryl-(C 1 -C 6 )-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C 1 -C 6 )- Alkyl, Heterocyclyl, Heterocyclyl-(C 1 -C 6 )-Alkyl stehen, R 30 und R 31 unabhängig voneinander für Wasserstoff, (C 1 -C 6 )-Alkyl, (C 2 -C 6 )-Alkenyl, (C 2 -C 6 )-Alkinyl, (C 1 -C 6 )-Cyanoalkyl, (C 1 -C 6 )-Haloalkyl, (C 2 -C 6 )-Haloalkenyl, (C 3 -C 6 )-Haloalkinyl, (C 3 -C 6 )- Cycloalkyl, (C 3 -C 6 )-Halocycloalkyl, (C 4 -C 6 )-Cycloalkenyl, (C 4 -C 6 )-Halocycloalkenyl, (C 1 -C 6 )- Alkoxy-(C 1 -C 6 )-alkyl, (C 1 -C 6 )-Haloalkoxy-(C 1 -C 6 )-alkyl, (C 1 -C 6 )-Alkylthio-(C 1 -C 6 )-alkyl, (C 1 -C 6 )-Haloalkylthio-(C 1 -C 6 )-alkyl, (C 1 -C 6 )-Alkoxy-(C 1 -C 6 )-haloalkyl, Aryl, Aryl-(C 1 -C 6 )- alkyl, Heteroaryl, Heteroaryl-(C 1 -C 6 )-alkyl, (C 3 -C 6 )-Cycloalkyl-(C 1 -C 6 )-alkyl, (C 4 -C 6 )- Cycloalkenyl-(C 1 -C 6 )-alkyl, COR 32 , SO2R 33 , Heterocyclyl, (C 1 -C 6 )-Alkoxycarbonyl, Bis-[(C 1 - C 6 )-alkyl]aminocarbonyl-(C 1 -C 6 )-alkyl, (C 1 -C 6 )-Alkyl-aminocarbonyl-(C 1 -C 6 )-alkyl, Aryl-(C 1 - C 6 )-alkyl-aminocarbonyl-(C 1 -C 6 )-alkyl, Aryl-(C 1 -C 6 )-alkoxycarbonyl, Heteroaryl-(C 1 -C 6 )- alkoxycarbonyl, (C 2 -C 6 )-Alkenyloxycarbonyl, (C 2 -C 6 )-Alkinyloxycarbonyl, Heterocyclyl- (C 1 -C 6 )-alkyl, (C 1 -C 6 )-Alkoxycarbonyl-(C 1 -C 6 )-alkyl, (C 2 -C 6 )-Alkenyloxycarbonyl- (C 1 -C 6 )-alkyl, (C 2 -C 6 )-Alkinyloxycarbonyl-(C 1 -C 6 )-alkyl, Aryl-(C 1 -C 6 )-alkoxycarbonyl- (C 1 -C 6 )-alkyl, Heteroaryl-(C 1 -C 6 )-alkoxycarbonyl-(C 1 -C 6 )-alkyl, Heterocyclyl-(C 1 -C 6 )- alkoxycarbonyl-(C 1 -C 6 )-alkyl stehen, oder R 30 und R 31 mit dem Stickstoffatom, an das sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 3 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, R 32 für Wasserstoff, (C 1 -C 6 )-Alkyl, (C 2 -C 6 )-Alkenyl, (C 2 -C 6 )-Alkinyl, (C 1 -C 6 )-Cyanoalkyl, (C 1 -C 6 )- Haloalkyl, (C 2 -C 6 )-Haloalkenyl, (C 3 -C 6 )-Haloalkinyl, (C 3 -C 6 )-Cycloalkyl, (C 3 -C 6 )- Halocycloalkyl, (C 4 -C 6 )-Cycloalkenyl, (C 4 -C 6 )-Halocycloalkenyl, (C 1 -C 6 )-Alkoxy-(C 1 -C 6 )-alkyl, (C 1 -C 6 )-Haloalkoxy-(C 1 -C 6 )-alkyl, (C 1 -C 6 )-Alkoxy-(C 1 -C 6 )-haloalkyl, (C 1 -C 6 )-Alkoxy-(C 1 -C 6 )- alkoxy-(C 1 -C 6 )-alkyl, (C 1 -C 6 )-Alkoxy-(C 1 -C 6 )-alkoxy-(C 1 -C 6 )-alkoxy-(C 1 -C 6 )-alkyl, (C 1 -C 6 )- Alkoxy-(C 1 -C 6 )-alkoxy-(C 1 -C 6 )-alkoxy-(C 1 -C 6 )-alkoxy-(C 1 -C 6 )-alkyl, Aryl, Aryl-(C 1 -C 6 )-alkyl, Aryl-(C 1 -C 6 )-alkoxy-(C 1 -C 6 )-alkyl, Heteroaryl, Heteroaryl-(C 1 -C 6 )-alkyl, (C 3 -C 6 )-Cycloalkyl- (C 1 -C 6 )-alkyl, (C 4 -C 6 )-Cycloalkenyl-(C 1 -C 6 )-alkyl, Bis-[(C 1 -C 6 )-alkyl]aminocarbonyl-(C 1 -C 6 )- alkyl, (C 1 -C 6 )-Alkyl-aminocarbonyl-(C 1 -C 6 )-alkyl, Aryl-(C 1 -C 6 )-alkyl-aminocarbonyl-(C 1 -C 6 )- alkyl, Bis-[(C 1 -C 6 )-alkyl]amino-(C 2 -C 6 )-alkyl, (C 1 -C 6 )-Alkyl-amino-(C 2 -C 6 )-alkyl, Aryl-(C 1 -C 6 )- alkyl-amino-(C 2 -C 6 )-alkyl, R 33 (O)mS-(C 1 -C 6 )-alkyl, Hydroxycarbonyl-(C 1 -C 6 )-alkyl, Heterocyclyl, Heterocyclyl-(C 1 -C 6 )-alkyl, Tris-[(C 1 -C 6 )-Alkyl]silyl-(C 1 -C 6 )-alkyl, Bis-[(C 1 -C 6 )- Alkyl](aryl)silyl(C 1 -C 6 )-alkyl, [(C 1 -C 6 )-Alkyl]-bis-(aryl)silyl-(C 1 -C 6 )-alkyl, (C 1 -C 6 )- Alkylcarbonyloxy-(C 1 -C 6 )-alkyl, (C 3 -C 6 )-Cycloalkylcarbonyloxy-(C 1 -C 6 )-alkyl, Arylcarbonyloxy-(C 1 -C 6 )-alkyl, Heteroarylcarbonyloxy-(C 1 -C 6 )-alkyl, Heterocyclylcarbonyloxy-(C 1 -C 6 )-alkyl, Aryloxy-(C 1 -C 6 )-alkyl, Heteroaryloxy-(C 1 -C 6 )-alkyl, Heterocyclyloxy-(C 1 -C 6 )-alkyl, (C 1 -C 6 )-Alkoxycarbonyl, (C 1 -C 6 )-Alkoxycarbonyl-(C 1 -C 6 )- alkyl, (C 2 -C 6 )-Alkenyloxycarbonyl-(C 1 -C 6 )-alkyl, (C 2 -C 6 )-Alkinyloxycarbonyl-(C 1 -C 6 )- alkyl, Aryl-(C 1 -C 6 )-alkoxycarbonyl-(C 1 -C 6 )-alkyl, Heteroaryl-(C 1 -C 6 )-alkoxycarbonyl- (C 1 -C 6 )-alkyl, Heterocyclyl-(C 1 -C 6 )-alkoxycarbonyl-(C 1 -C 6 )-alkyl steht, R 33 für Wasserstoff, (C 1 -C 6 )-Alkyl, (C 2 -C 6 )-Alkenyl, (C 2 -C 6 )-Alkinyl, (C 1 -C 6 )-Cyanoalkyl, (C 1 -C 6 )- Haloalkyl, (C 2 -C 6 )-Haloalkenyl, (C 3 -C 6 )-Haloalkinyl, (C 3 -C 10 )-Cycloalkyl, (C 3 -C 10 )- Halocycloalkyl, (C 4 -C 6 )-Cycloalkenyl, (C 4 -C 6 )-Halocycloalkenyl, (C 1 -C 6 )-Alkoxy-(C 1 -C 6 )-alkyl, (C 1 -C 6 )-Alkoxy-(C 1 -C 6 )-haloalkyl, Aryl, Aryl-(C 1 -C 6 )-alkyl, Heteroaryl, Heteroaryl-(C 1 -C 6 )- alkyl, Heterocyclyl-(C 1 -C 6 )-alkyl, (C 3 -C 6 )-Cycloalkyl-(C 1 -C 6 )-alkyl, (C 4 -C 10 )-Cycloalkenyl- (C 1 -C 6 )-alkyl, Bis-[(C 1 -C 6 )-alkyl]amino, (C 1 -C 6 )-Alkyl-amino, Aryl-(C 1 -C 6 )-amino, Aryl-(C 1 - C 6 )-alkyl-amino, Aryl-[(C 1 -C 6 )-alkyl]amino; Heteroaryl-(C 1 -C 6 )-amino, Heteroaryl-(C 1 -C 6 )- alkyl-amino, Heteroaryl-[(C 1 -C 6 )-alkyl]amino; Hetercyclyl-(C 1 -C 6 )-amino, Heterocyclyl-(C 1 - C 6 )-alkyl-amino, Heterocyclyl-[(C 1 -C 6 )-alkyl]amino; (C 3 -C 6 )-Cycloalkyl-amino, (C 3 -C 6 )- Cycloalkyl-[(C 1 -C 6 )-alkyl]amino; N-Azetidinyl, N-Pyrrolidinyl, N-Piperidinyl. N-Morpholinyl steht, R 34 für Wasserstoff, (C 1 -C 6 )-Alkyl, (C 2 -C 6 )-Alkenyl, Aryl-(C 1 -C 6 )-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C 1 -C 6 )-Alkyl, Heterocyclyl, Heterocyclyl-(C 1 -C 6 )-Alkyl, R 32 O-(C 1 -C 6 )-Alkyl, R 30 R 31 N-(C 1 -C 6 )-Alkyl, NR 30 R 31 , (C 3 -C 6 )-Cycloalkyl-(C 1 -C 6 )-Alkyl, S(O) m R 33 steht, R 35 für Wasserstoff, NR 30 R 31 , OR 32 , (C 1 -C 6 )-Alkyl, (C 2 -C 6 )-Alkenyl, (C 2 -C 6 )-Alkinyl, Aryl, Aryl- (C 1 -C 6 )-Alkyl, Heteroaryl, Heteroaryl-(C 1 -C 6 )-Alkyl, Heterocyclyl, Heterocyclyl-(C 1 -C 6 )-Alkyl, R 32 O-(C 1 -C 6 )-Alkyl, (C 3 -C 6 )-Cycloalkyl, (C 3 -C 6 )-Cycloalkyl-(C 1 -C 6 )-Alkyl, S(O) m R 33 , R 32 (O=)C-(C 1 -C 6 )-Alkyl, R 32 O(O)C-(C 1 -C 6 )-Alkyl, R 30 R 31 N(O)C-(C 1 -C 6 )-Alkyl, R 33 S(O) m - (C 1 -C 6 )-alkyl, R 32 O-(C 1 -C 6 )-Alkyl, R 30 R 31 N-(C 1 -C 6 )-Alkyl steht, R 36 für Wasserstoff, (C 1 -C 6 )-Alkyl, (C 2 -C 6 )-Alkenyl, (C 2 -C 6 )-Alkinyl, Aryl, Aryl-(C 1 -C 6 )-Alkyl, Heteroaryl, Heteroaryl-(C 1 -C 6 )-Alkyl, Heterocyclyl, Heterocyclyl-(C 1 -C 6 )-Alkyl, (C 3 -C 10 )- Cycloalkyl, (C 3 -C 6 )-Cycloalkyl-(C 1 -C 6 )-Alkyl, R 32 (O=)C-(C 1 -C 6 )-Alkyl, R 32 O(O)C-(C 1 -C 6 )- Alkyl, R 30 R 31 N(O)C-(C 1 -C 6 )-Alkyl, R 33 S(O)m-(C 1 -C 6 )-alkyl, R 32 O-(C 1 -C 6 )-Alkyl, R 30 R 31 N- (C 1 -C 6 )-Alkyl steht, R 37 für (C 1 -C 6 )-Alkyl, (C 2 -C 6 )-Alkenyl, (C 2 -C 6 )-Alkinyl, (C 1 -C 6 )-Haloalkyl, (C 2 -C 6 )-Haloalkenyl, (C 2 -C 6 )-Haloalkinyl, (C 3 -C 6 )-Cycloalkyl, (C 3 -C 6 )-Halocycloalkyl, (C 4 -C 6 )-Cycloalkenyl, (C 4 -C 6 )-Halocycloalkenyl, Aryl, Aryl-(C 1 -C 6 )-Alkyl, Heteroaryl, Heteroaryl-(C 1 -C 6 )-Alkyl, Heterocyclyl, Heterocyclyl-(C 1 -C 6 )-Alkyl, Heteroaryloxy-(C 1 -C 6 )-Alkyl, Aryloxy-(C 1 -C 6 )- Alkyl, Heterocyclyloxy-(C 1 -C 6 )-Alkyl, R 32 O-(C 1 -C 6 )-Alkyl, R 30 R 31 N-(C 1 -C 6 )-Alkyl, R 32 O(O)C- (C 1 -C 6 )-Alkyl, R 30 R 31 N(O)C-(C 1 -C 6 )-Alkyl, (C 3 -C 6 )-Cycloalkyl-(C 1 -C 6 )-Alkyl, R 33 S(O)m- (C 1 -C 6 )-alkyl, R 32 (O=)C-(C 1 -C 6 )-Alkyl steht und R 38 für (C 1 -C 8 )-Alkyl, (C 2 -C 8 )-Alkenyl, (C 2 -C 8 )-Alkinyl, Aryl, Aryl-(C 1 -C 8 )-Alkyl, Heteroaryl, Heteroaryl-(C 1 -C 8 )-Alkyl, Heterocyclyl, Heterocyclyl-(C 1 -C 8 )-Alkyl, (C 3 -C 10 )-Cycloalkyl, (C 3 -C 10 )-Cycloalkyl-(C 1 -C 8 )-Alkyl, R 32 (O=)C-(C 1 -C 8 )-Alkyl, R 32 O(O)C-(C 1 -C 8 )-Alkyl, R 30 R 31 N(O)C-(C 1 -C 8 )-Alkyl, R 33 S(O)m-(C 1 -C 8 )-alkyl, R 32 O-(C 1 -C 8 )-Alkyl, R 30 R 31 N-(C 1 -C 8 )- Alkyl steht. Im Speziellen bevorzugter Erfindungsgegenstand ist die Verwendung der folgenden von der allgemeinen Formel (I) beschriebenen Verbindungen: 2-[1-[(3-Chlor-2-fluorphenyl)methyl]-5-oxopyrrolidin-2-yl]es sigsäure, 2-[1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(1-methyl-1H-1 ,2,4-triazol-5-yl)acetamid, 2-[1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]essigsäure, 2-[1-[(2,3-difluorphenyl)methyl]-5- oxopyrrolidin-2-yl]-N-(1-methyl-1H-tetrazol-5-yl)acetamid, (2S,3S)-2-[[2-[(2S)-1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-3-m ethylpentancarbonsäure, Methyl 5-[[2-[1- [(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amin o]-4-oxopentanoat, 2-(4- fluorphenoxy)ethyl 2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat , Methyl 2-[1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, 2-methylsulfonylethyl 2-[1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, 2-methylsulfanylethyl 2-[1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, (2S,3S)-2-[[2-[(2R)-1-[(2,3-difluorphenyl)methyl]-5- oxopyrrolidin-2-yl]acetyl]amino]-3-methylpentancarbonsäure, 2-[1-[(2,3-difluorphenyl)methyl]-5- oxopyrrolidin-2-yl]-N-methylsulfonylacetamid, 1-[2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2- yl]acetyl]pyrrolidine-2-carbonsäure, 2-[(2R)-1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2- yl]essigsäure, 2-methoxyethyl 2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat , (2R,3R)-2- [[2-[(2R)-1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl ]acetyl]amino]-3- methylpentancarbonsäure, Cyclopentyl 2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat , 2,2-Dimethylpropyl 2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat , Ethyl 2-[1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, cyclopropylmethyl 2-[1-[(2,3-difluorphenyl)methyl]- 5-oxopyrrolidin-2-yl]acetat, allyl 2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat , 2-[1-[(3- Chlorphenyl)methyl]-5-oxopyrrolidin-2-yl]essigsäure, 2-Phenylsulfanylethyl 2-[1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, Prop-2-yn-1-yl 2-[1-[(2,3-difluorphenyl)methyl]-5- oxopyrrolidin-2-yl]acetat, Cyclobutyl 2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat , Isopropyl 2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat , But-3-en-1-yl 2-[1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, 2-Phenoxyethyl 2-[1-[(2,3-difluorphenyl)methyl]-5- oxopyrrolidin-2-yl]acetat, Pentan-2-yl 2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat , 2- (4-Chlorphenyl)sulfinylethyl 2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat , Butan-2-yl 2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat , 2-(4-Methoxyphenoxy)ethyl 2-[1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, 2-[1-[(3,4-Difluorphenyl)methyl]-5-oxopyrrolidin-2- yl]essigsäure, 2-(Benzylsulfonyl)ethyl 2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat , 2- (4-chlorphenoxy)ethyl 2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat , 2-(4- methylphenoxy)ethyl 2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat , 2-[1-[(2,3-difluor-4- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]essigsäure, 3-methylbutan-2-yl 2-[1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, methyl (2S)-2-[[2-[(2R)-1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-3-( 1H-imidazol-4-yl)propionat, 2-[(4- chlorphenyl)thio]ethyl 2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat , 2-[(2S)-1-[(3,4- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]essigsäure, 2-phenylsulfanylethyl 2-[1-[(3,4- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, 2-(4-chlorphenyl)sulfinylethyl 2-[1-[(4- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, 2-[(2R)-1-[(3,4-difluorphenyl)methyl]-5- oxopyrrolidin-2-yl]essigsäure, 2-[1-[(3-fluorphenyl)methyl]-5-oxopyrrolidin-2-yl]essigsäur e, (2R)-2- [[2-[(2R)-1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl ]acetyl]amino]-3-phenylpropionsäure, 2- [(4-methoxyphenyl)thio]ethyl 2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat , 2-[(4- methylphenyl)thio]ethyl 2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat , methyl 2-[1-[(3- chlor-2-fluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, (2R,3R)-2-[[2-[(2S)-1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-3-m ethylpentancarbonsäure, 2-(4- fluorphenoxy)ethyl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, (2R)-2-[[2-[1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-3-p henylpropionsäure, 4-[2-[2-[1-[(4- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]oxyethoxy]b enzoesäure, (2R)-2-[[2-[1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-4-m ethylpentancarbonsäure, 2-[1-[(3,4- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-methyl-N-methy lsulfonylacetamid, 2-[1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(4-methyl-1,2, 5-oxadiazol-3-yl)acetamid, 2-(4- chlorphenoxy)ethyl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, 2-(4- methylphenyl)sulfinylethyl 2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat , 2-[1-[(2,4- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]essigsäure, 2-phenylsulfanylethyl 2-[1-[(3- fluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, methyl 2-[1-[(3-fluorphenyl)methyl]-5-oxopyrrolidin- 2-yl]acetat, 2-[1-[(3,5-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]essigs äure, methyl 1-[[2-[1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]cycl opropanecarboxylat, 2-(2,4- dichlorphenoxy)ethyl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, 2-[1-[(4- fluorphenyl)methyl]-5-oxopyrrolidin-2-yl]essigsäure, ethyl 2-(1-benzyl-5-oxopyrrolidin-2-yl)acetat, 2- [1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(2-hy droxyethyl)acetamid, methyl 2-[1-[(3,4- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, (2S)-2-[[2-[(2R)-1-[(4-ethylphenyl)methyl]-5- oxopyrrolidin-2-yl]acetyl]amino]-4-methylpentancarbonsäure, methyl (2S)-2-[[2-[(2S)-1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-3-( 1H-imidazol-4-yl)propionate, 2-[1-[(2- fluorphenyl)methyl]-5-oxopyrrolidin-2-yl]essigsäure, 2-(1-benzyl-5-oxopyrrolidin-2-yl)essigsäure, 2-[1- [(3-fluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, (2S)-2-[[2-[1-[(2,3-difluorphenyl)methyl]-5- oxopyrrolidin-2-yl]acetyl]amino]-3-phenylpropionsäure, 2-[1-[(2,3-difluorphenyl)methyl]-5- oxopyrrolidin-2-yl]-N-(trifluormethylsulfonyl)acetamid, 2-[1-[(3-fluorphenyl)methyl]-5-oxopyrrolidin- 2-yl]-N-methyl-N-methylsulfonylacetamid, methyl 2-[[2-[1-[(2,3-difluorphenyl)methyl]-5- oxopyrrolidin-2-yl]acetyl]-methylamino]acetat, 2-(4-methoxyphenyl)sulfonylethyl 2-[1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2- yl]essigsäure, methyl 5-[[2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acety l]amino]-4- oxopentanoat, methyl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, N-benzyl-2-[1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, (2S)-4-methyl-2-[[2-[1-[(3- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]penta ncarbonsäure, N-[2-(3- methylphenyl)ethyl]-2-[1-[(4-methylphenyl)methyl]-5-oxopyrro lidin-2-yl]acetamid, 2-[1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(2-methylpropy l)acetamid, 2-[1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, 2-[1-[(2,3-difluorphenyl)methyl]-5- oxopyrrolidin-2-yl]-N',N'-dimethylacetohydrazid, N-(2-hydroxyethyl)-2-[1-[(4-methylphenyl)methyl]-5- oxopyrrolidin-2-yl]acetamid, 2-(4-formylphenoxy)ethyl 2-[1-[(4-methylphenyl)methyl]-5- oxopyrrolidin-2-yl]acetat, N-allyl-2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-y l]acetamid, N- [(1-ethyl-3-methyl-1H-pyrazol-4-yl)methyl]-2-[1-[(4-methylph enyl)methyl]-5-oxopyrrolidin-2- yl]acetamid, 2-(4-methoxyphenyl)sulfinylethyl 2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2- yl]acetat, (2R,3R)-2-[[2-[(2S)-1-[(2-ethylphenyl)methyl]-5-oxopyrrolidi n-2-yl]acetyl]amino]-3- methylpentancarbonsäure, N-methyl-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl] -N- methylsulfonylacetamid, 2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(2- phenylethyl)acetamid, 2-(2,4-dimethylphenoxy)ethyl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2- yl]acetat, N-[(6-chlorpyridin-3-yl)methyl]-2-[1-[(2,3-difluorphenyl)met hyl]-5-oxopyrrolidin-2-yl]-N- methylacetamid, (2R)-2-[[2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl] acetyl]amino]-4- methylsulfanylbuttersäure, methyl 3-[[2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2- yl]acetyl]amino]butyrat, 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(2- methylpropyl)acetamid, methyl 3-[[2-[1-[(3-fluorphenyl)methyl]-5-oxopyrrolidin-2- yl]acetyl]amino]propionat, 2-[1-[(3-chlorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N- (trifluormethylsulfonyl)acetamid, methyl 3-[[2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2- yl]acetyl]amino]butyrate, [(1S,2R,5R)-2-isopropyl-5-methylcyclohexyl] 2-[(2R)-1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, 2-[(2S)-1-[(2,3-difluorphenyl)methyl]-5- oxopyrrolidin-2-yl]essigsäure, 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-prop-2 -yn-1- ylacetamid, 2-(4-bromophenoxy)ethyl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, 2-[1- [(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(1,2,3,4 -tetrahydronaphthalen-1-yl)acetamid, [(1S,2R,5S)-2-isopropyl-5-methylcyclohexyl] 2-[(2R)-1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2- yl]acetat, 2-[5-oxo-3-phenyl-1-(pyridin-2-ylmethyl)pyrrolidin-2-yl]essi gsäure, 2-[1-[(4- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-propylacetamid, (2S)-2-[[2-[1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-3-( 1H-indol-3-yl)propionsäure, (2R)-2-[[2- [1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]a mino]-3-(1H-indol-3-yl)propionsäure, 2-[1- [(3-chlor-2-fluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-meth ylsulfonylacetamid, 2-[5-oxo-1-[(3,4,5- trifluorphenyl)methyl]pyrrolidin-2-yl]essigsäure, 2-(4-ethylphenoxy)ethyl 2-[1-[(4- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, 2-phenoxyethyl 2-[1-[(4-methylphenyl)methyl]-5- oxopyrrolidin-2-yl]acetat, 1-[(2,3-difluorphenyl)methyl]-5-(2-oxo-2-pyrrolidin-1-ylethy l)pyrrolidin-2- on, 2-(4-methylphenoxy)ethyl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, 2-[1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-ethylsulfonyla cetamid, (2S)-2-[[2-[(2S)-1-[(4- ethylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-4-met hylpentancarbonsäure, 2-[1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N,N-diethylaceta mid, 2-[1-[(3-chlorphenyl)methyl]-5- oxopyrrolidin-2-yl]-N-(difluormethylsulfonyl)acetamid, Ethyl-(2R)-1-[2-[(2S)-1-[(4- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]piperidine- 2-carboxylat, 2-[3- (trifluormethyl)phenoxy]ethyl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, 2-(4-tert- butylphenoxy)ethyl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, N- (difluormethylsulfonyl)-2-[1-[(2,3-difluorphenyl)methyl]-5-o xopyrrolidin-2-yl]acetamid, 2- methoxyethyl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, 2-[(4-chlorphenyl)thio]ethyl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, 2-[(2R)-1-[(2,3-difluorphenyl)methyl]-5- oxopyrrolidin-2-yl]-N-(1-methyl-1H-1,2,4-triazol-5-yl)acetam id, 2-[1-[(4-chlorphenyl)methyl]-5- oxopyrrolidin-2-yl]essigsäure, 2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N- isopropylsulfonylacetamid, 2-[1-[(2,3-dichlorphenyl)methyl]-5-oxopyrrolidin-2-yl]essigs äure, (2R,3R)- 2-[[2-[(2R)-1-[(2-ethylphenyl)methyl]-5-oxopyrrolidin-2-yl]a cetyl]amino]-3-methylpentancarbonsäure, 2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(py ridin-2-ylmethyl)acetamid, 2-[1-[(3,4- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, 2-[1-[(2,3-difluorphenyl)methyl]-5- oxopyrrolidin-2-yl]-N-(chinolin-5-ylmethyl)acetamid, 2,2-dimethylpropyl 2-[1-[(4- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, 2-(2-chlorphenoxy)ethyl 2-[1-[(4- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, 2-methylsulfanylethyl 2-[1-[(4- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, 2-[1-[[3-fluor-5-(trifluormethyl)phenyl]methyl]-5- oxopyrrolidin-2-yl]essigsäure, ethyl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, 2-(2- chlorphenyl)sulfonylethyl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, methyl 2-[[2-[1- [(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amin o]benzoate, 2-(2,4- dichlorphenyl)sulfonylethyl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, N-[2-(3,4- dichlorphenyl)ethyl]-2-[1-[(2,3-difluorphenyl)methyl]-5-oxop yrrolidin-2-yl]acetamid, prop-2-yn-1-yl 2- [1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, 2-[1-[(2,3-difluorphenyl)methyl]-5- oxopyrrolidin-2-yl]-N-(2,2,2-trifluorethylsulfonyl)acetamid, N-benzyl-2-[1-[(4-methylphenyl)methyl]- 5-oxopyrrolidin-2-yl]acetamid, 2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N- (dimethylsulfamoyl)acetamid, methyl 3-[[2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2- yl]acetyl]amino]propionate, 2-phenylsulfanylethyl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2- yl]acetat, N-[2-(1,3-benzodioxol-5-yl)ethyl]-2-[1-[(4-methylphenyl)meth yl]-5-oxopyrrolidin-2- yl]acetamid, 2-[1-[1-(4-fluorphenyl)cyclopropyl]-5-oxopyrrolidin-2-yl]ess igsäure, 2-[1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-[(1-ethyl-1H-p yrazol-3-yl)methyl]acetamid, but-3-en-1- yl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, methyl (2S)-3-(1H-imidazol-4-yl)-2-[[2- [(2S)-1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-,yl]acety l]amino]propionate, 2-[1-[(3- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]essigsäure, N-(difluormethylsulfonyl)-2-[1-[(3- fluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, methyl 4-[2-[2-[1-[(4-methylphenyl)methyl]-5- oxopyrrolidin-2-yl]acetyl]oxyethoxy]benzoat, N-cyclopropylsulfonyl-2-[1-[(2,3-difluorphenyl)methyl]- 5-oxopyrrolidin-2-yl]acetamid, 2-[1-[(2,3-difluor-4-methylphenyl)methyl]-5-oxopyrrolidin-2- yl]-N- methylsulfonylacetamid, 2-[1-[(2,3-dichlorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N- (trifluormethylsulfonyl)acetamid, 2-[1-[(3,4-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N- (dimethylsulfamoyl)acetamid, 2-[1-[[3,5-bis(trifluormethyl)phenyl]methyl]-5-oxopyrrolidin -2- yl]essigsäure, 2-[1-[(3-chlorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-methyls ulfonylacetamid, N- cyclopropyl-2-[1-[(3-fluorphenyl)methyl]-5-oxopyrrolidin-2-y l]acetamid, 2-[1-[(4-ethylphenyl)methyl]- 5-oxopyrrolidin-2-yl]-N-methylsulfonylacetamid, (2S)-2-[[2-[(2S)-1-[(2-ethylphenyl)methyl]-5- oxopyrrolidin-2-yl]acetyl]amino]-4-methylpentancarbonsäure, cyclopropylmethyl 2-[1-[(4- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, 2-[1-[(4-chlorphenyl)methyl]-5-oxopyrrolidin-2-yl]- N-methylsulfonylacetamid, tert-butyl 2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat , 2- [1-[[3-(difluormethoxy)phenyl]methyl]-5-oxopyrrolidin-2-yl]e ssigsäure, 2-[1-[(3-fluorphenyl)methyl]- 5-oxopyrrolidin-2-yl]-N-methylsulfonylacetamid, 2-[4-(acetylamino)phenoxy]ethyl 2-[1-[(4- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, N-[2-(4-tert-butylphenyl)ethyl]-2-[1-[(4- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, 2-[1-[(2,3-difluorphenyl)methyl]-5- oxopyrrolidin-2-yl]-N-(2,2,2-trifluorethyl)acetamid, 2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin- 2-yl]-N-(2-methoxyethyl)acetamid, 2-[1-[2-(4-fluorphenyl)propan-2-yl]-5-oxopyrrolidin-2- yl]essigsäure, 2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-pro p-2-yn-1-ylacetamid, 2-[1- [(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-[(2-ethy lphenyl)methyl]acetamid, 2-[1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-[(1-ethyl-3-me thyl-1H-pyrazol-4-yl)methyl]acetamid, N-[(6-chlorpyridin-3-yl)methyl]-2-[1-[(4-methylphenyl)methyl ]-5-oxopyrrolidin-2-yl]acetamid, 2-[1- [(2,3-dichlorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(difluor methylsulfonyl)acetamid, isopropyl 2-[1- [(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, cyclobutyl 2-[1-[(4-methylphenyl)methyl]-5- oxopyrrolidin-2-yl]acetat, 2-[1-[[4-(difluormethoxy)phenyl]methyl]-5-oxopyrrolidin-2-yl ]essigsäure, 2- [1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(3-me thylbutyl)acetamid, N-[2-(2- bromophenyl)ethyl]-2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyr rolidin-2-yl]acetamid, 2-[1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-ethylacetamid, (2R)-4-methyl-2-[[2-[1-[(4- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]penta ncarbonsäure, 2-[5-oxo-1-[[3- (trifluormethyl)phenyl]methyl]-pyrrolidin-2-yl]essigsäure, 2-[1-[(2,3-difluorphenyl)methyl]-5- oxopyrrolidin-2-yl]-N-[2-(3,5-dimethoxyphenyl)ethyl]acetamid , 2-[1-[(2,3-difluorphenyl)methyl]-5- oxopyrrolidin-2-yl]-N-methyl-N-phenylacetamid, N-isopropyl-2-[1-[(4-methylphenyl)methyl]-5- oxopyrrolidin-2-yl]acetamid, Natrium;[2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2- yl]acetyl]- methylsulfonylazanid, N-[(6-chlorpyridin-3-yl)methyl]-2-[1-[(2,3-difluorphenyl)met hyl]-5- oxopyrrolidin-2-yl]acetamid, methyl 3-[[2-[1-[(3,4-difluorphenyl)methyl]-5-oxopyrrolidin-2- yl]acetyl]amino]propionate, N-[2-(2,4-difluorphenyl)ethyl]-2-[1-[(2,3-difluorphenyl)meth yl]-5- oxopyrrolidin-2-yl]acetamid, cyclopentyl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, 2- [5-oxo-1-[(1R)-1-phenylethyl]pyrrolidin-2-yl]essigsäure, 2-[1-[(2,3-difluorphenyl)methyl]-5- oxopyrrolidin-2-yl]-N-methylacetamid, allyl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2- yl]acetat, 2-[1-[(2,4-dichlorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(tr ifluormethylsulfonyl)acetamid, 2-[1-[(2,3-dichlorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-met hylsulfonylacetamid, methyl 2-[methyl- [2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]a mino]acetat, 2-[1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-[(1R,2S)-2,6-d imethylindan-1-yl]acetamid, 2-[1-[(4- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-methylsulfonyla cetamid, 2-[5-oxo-1-[[3- (trifluormethoxy)phenyl]methyl]pyrrolidin-2-yl]essigsäure, N-(difluormethylsulfonyl)-2-[1-[(3,4- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, N-[2-(1,3-benzodioxol-5-yl)ethyl]-2-[1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, butan-2-yl 2-[1-[(4-methylphenyl)methyl]-5- oxopyrrolidin-2-yl]acetat, N-butan-2-yl-2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidi n-2- yl]acetamid, 2-[1-[(2-chlorphenyl)methyl]-5-oxopyrrolidin-2-yl]essigsäur e, 2-[1-[(3,4- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-methylsulfonyl acetamid, (2S)-3-(1H-indol-3-yl)-2-[[2- [1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amin o]propionsäure, (2R)-2-[[2-[1-[(3- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-3-ph enylpropionsäure, 2-[1-[(4- chlorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(trifluormethyls ulfonyl)acetamid, 2-[1-[(2,4- dichlorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(furan-2-ylmet hyl)acetamid, (2S)-2-[[2-[(2R)-1-[(2- ethylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-4-met hylpentancarbonsäure, 2-[5-oxo-1-[[3- (pentafluor-λ6-sulfanyl)phenyl]methyl]pyrrolidin-2-yl]essig säure, 2-[1-[(3-methylphenyl)methyl]-5- oxopyrrolidin-2-yl]-N-(1-methyl-1H-1,2,4-triazol-5-yl)acetam id, 1-[(4-tert-butylphenyl)methyl]-5-[2- oxo-2-(2-thiophen-2-ylazepan-1-yl)ethyl]pyrrolidin-2-on, 2-[1-[(4-tert-butylphenyl)methyl]-5- oxopyrrolidin-2-yl]essigsäure, 2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-[2- (1H-indol- 3-yl)ethyl]acetamid, 2-[1-[(2,4-dichlorphenyl)methyl]-5-oxopyrrolidin-2-yl]essigs äure, pentan-2-yl 2- [1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, 1-[(4-methylphenyl)methyl]-5-(2-oxo-2- pyrrolidin-1-ylethyl)pyrrolidin-2-on, 2-[5-oxo-1-[[6-(trifluormethyl)pyridin-3-yl]methyl]pyrrolidi n-2- yl]essigsäure, 2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-pro pylacetamid, N- (difluormethylsulfonyl)-2-[1-[(4-methylphenyl)methyl]-5-oxop yrrolidin-2-yl]acetamid, 2-[1-[(2,2- difluor-1,3-benzodioxol-5-yl)methyl]-5-oxopyrrolidin-2-yl]es sigsäure, 2-[1-[(3-chlorphenyl)methyl]-5- oxopyrrolidin-2-yl]-N-(dimethylsulfamoyl)acetamid, N-[(2-fluorphenyl)methyl]-2-[5-oxo-1-[(4- phenylphenyl)methyl]pyrrolidin-2-yl]acetamid, N-butan-2-yl-2-[1-[(4-methylphenyl)methyl]-5- oxopyrrolidin-2-yl]acetamid, 2-[1-[(4-methoxyphenyl)methyl]-5-oxopyrrolidin-2-yl]essigsä ure, N-[2-(2- fluorphenyl)ethyl]-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrol idin-2-yl]acetamid, N-[2-(2,6- difluorphenyl)ethyl]-2-[1-[(2,3-difluorphenyl)methyl]-5-oxop yrrolidin-2-yl]acetamid, 2-[1-[(2,4- dichlorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-[(2-fluorpheny l)methyl]acetamid, 2-[1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-[2-(3-methylph enyl)ethyl]acetamid, (2R)-4-methyl-2- [[2-[(2R)-1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]ac etyl]amino]pentancarbonsäure, N- (dimethylsulfamoyl)-2-[1-[(3-fluorphenyl)methyl]-5-oxopyrrol idin-2-yl]acetamid, N-benzhydryl-2-[1- [(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, N-methyl-2-[1-[(4-methylphenyl)methyl]-5- oxopyrrolidin-2-yl]-N-phenylacetamid, 1-[(2,4-dichlorphenyl)methyl]-5-[2-(4-methylpiperazin-1-yl)- 2- oxoethyl]pyrrolidin-2-on, [(1S,2R,5S)-2-isopropyl-5-methylcyclohexyl] 2-[(2S)-1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, 2-[5-oxo-1-(pyridin-2-ylmethyl)pyrrolidin-2- yl]essigsäure, 2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-[2- [3-(trifluormethoxy)phenyl]- ethyl]acetamid, 2-[5-oxo-1-[[4-(pentafluor-λ6-sulfanyl)phenyl]methyl]pyrrol idin-2-yl]essigsäure, 4-[[2- (carboxymethyl)-5-oxopyrrolidin-1-yl]methyl]benzoesäure, N-[2-(3,4-dichlorphenyl)ethyl]-2-[1-[(4- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, N-cyclopropyl-2-[1-[(3,4-difluorphenyl)methyl]- 5-oxopyrrolidin-2-yl]acetamid, 2-[1-[[3-fluor-2-(trifluormethyl)phenyl]methyl]-5-oxopyrroli din-2- yl]essigsäure, 2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-ind an-1-ylacetamid, 2-[1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(chinolin-6-yl methyl)acetamid, 2-[1-[(4-tert- butylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(furan-2-ylmethy l)acetamid, (2R)-4-methyl-2-[[2-[(2S)-1- [(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]p entancarbonsäure, 2-[5-oxo-1-(pyridin-4- ylmethyl)pyrrolidin-2-yl]essigsäure, 2-[1-[(4-isopropylphenyl)methyl]-5-oxopyrrolidin-2-yl]essigs äure, 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(2,2,2 -trifluorethyl)acetamid, tert-butyl (2S)-2- [[2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acet yl]amino]-3-(4-hydroxyphenyl)propionat, N-[2-(4-tert-butylphenyl)ethyl]-2-[1-[(2,3-difluorphenyl)met hyl]-5-oxopyrrolidin-2-yl]acetamid, 2-[5- oxo-1-(pyridin-3-ylmethyl)pyrrolidin-2-yl]essigsäure, 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin- 2-yl]acetamid, methyl (2S)-2-[[2-[1-[(4-isopropylphenyl)methyl]-5-oxopyrrolidin-2- yl]acetyl]amino]-4- methylpentanoat, [(Z)-[3-(dimethylamino)propylamino]-(ethylimino)methyl] 2-[1-[(2,4- dichlorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, N-[(2-ethylphenyl)methyl]-2-[1-[(4- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, 2-[(2R)-1-[(2,3-difluorphenyl)methyl]-5- oxopyrrolidin-2-yl]-N-methylsulfonylacetamid, 2-[1-[(4-chlorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N- (dimethylsulfamoyl)acetamid, N-cyclopropyl-2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolid in-2- yl]acetamid, (2S)-2-[[2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl] acetyl]amino]-3- phenylpropionsäure, 2-[[2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acety l]amino]-3- phenylpropionsäure, 3-methylbutan-2-yl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, methyl 3-[[2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acety l]amino]propionat, 2-[1-[(2,4- dichlorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(difluormethyl sulfonyl)acetamid, (2R)-2-[[2-[(2S)-1- [(2-ethylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-3 -phenylpropionsäure, 2-[[2-[1-[(4- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-4-me thylsulfanylbuttersäure, (2R)-2-[[2- [(2R)-1-[(2-ethylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl] amino]-3-phenylpropionsäure, 2-[1-[(2,4- dichlorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-ethylacetamid, 2-[1-[1-(4-fluorphenyl)ethyl]-5- oxopyrrolidin-2-yl]essigsäure, 2-[1-[(2,6-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]essigs äure, 2-[1- [1-(3-fluorphenyl)ethyl]-5-oxopyrrolidin-2-yl]essigsäure, 1-[2-[1-[(4-methylphenyl)methyl]-5- oxopyrrolidin-2-yl]acetyl]pyrrolidine-2-carboxylic acid, 2-[1-[(4-cyanophenyl)methyl]-5-oxopyrrolidin- 2-yl]essigsäure, 2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-iso propylacetamid, ethyl 1- [2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acety l]piperidin-2-carboxylat, 2-[1-[(2- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]essigsäure, (2S)-2-[[(2S)-2-[[2-[1-[(4- isopropylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-4 -methylpentanoyl]amino]-4- methylpentancarbonsäure, 2-[5-oxo-1-[[4-(trifluormethylthio)phenyl]methyl]pyrrolidin- 2-yl]essigsäure, 2-[1-[(4-chlorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(difluo rmethylsulfonyl)acetamid, 2-[1-[(4- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(trifluormethyl sulfonyl)acetamid, 2-[(2S)-1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(1-methyl-1H-1 ,2,4-triazol-5-yl)acetamid, (2R)-2-[[2- [(2R)-1-[(2-ethylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl] amino]-4-methylpentancarbonsäure, (2S)- 2-[[2-[(2S)-1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl] acetyl]amino]-3-phenylpropionsäure, 2- [1-[(2-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-methylsu lfonylacetamid, 2-[1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-[2-(2-fluorphe nyl)ethyl]acetamid, 1-[(2,4- dichlorphenyl)methyl]-5-[2-oxo-2-(2-propylpyrrolidin-1-yl)et hyl]pyrrolidin-2-on, methyl 2-[[2-[(2S)-1- [(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]-met hylamino]acetat, 2-[1-[(2,4- dichlorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(dimethylsulfa moyl)acetamid, 2-[1-[(4- methylphenyl)methyl]-5-oxo-3-phenylpyrrolidin-2-yl]-N-methyl sulfonylacetamid, N-[2-(2,6- difluorphenyl)ethyl]-2-[1-[(4-methylphenyl)methyl]-5-oxopyrr olidin-2-yl]acetamid, N-cyclopropyl-2- [1-[(2-ethylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, 2-[(2S)-1-[(2,3-difluorphenyl)methyl]-5- oxopyrrolidin-2-yl]-N-methylsulfonylacetamid, ethyl 1-[2-[(2R)-1-[(2,3-difluorphenyl)methyl]-5- oxopyrrolidin-2-yl]acetyl]piperidine-2-carboxylat, methyl 2-[[2-[1-[(4-methylphenyl)methyl]-5- oxopyrrolidin-2-yl]acetyl]amino]benzoat, 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N- phenylacetamid, N-[(6-chlorpyridin-3-yl)methyl]-N-methyl-2-[1-[(4-methylphen yl)methyl]-5- oxopyrrolidin-2-yl]acetamid, N-benzhydryl-2-[(2S)-1-[(2,3-difluorphenyl)methyl]-5-oxopyrr olidin-2- yl]acetamid, N-cyclopropyl-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin- 2-yl]acetamid, 2-[1-[1-(3,4- difluorphenyl)ethyl]-5-oxopyrrolidin-2-yl]essigsäure, 2-[1-[(2,3-dichlorphenyl)methyl]-5-oxopyrrolidin- 2-yl]-N-(dimethylsulfamoyl)acetamid, (2S)-1-[2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2- yl]acetyl]pyrrolidin-2-carbonsäure, 2-[1-[(3,4-dichlorphenyl)methyl]-5-oxopyrrolidin-2-yl]essigs äure, N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-2-[1-[(4-methylphenyl)m ethyl]-5-oxopyrrolidin-2-yl]acetamid, N-[(2-fluorphenyl)methyl]-2-[1-[(4-methylphenyl)methyl]-5-ox opyrrolidin-2-yl]acetamid, 2-(1-benzyl- 5-oxopyrrolidin-2-yl)-N-(2-phenylethyl)acetamid, 2-[1-[(2,4-dichlorphenyl)methyl]-5-oxopyrrolidin-2- yl]-N,N-dimethylacetamid, N-(dimethylsulfamoyl)-2-[1-[(4-methylphenyl)methyl]-5-oxopyr rolidin-2- yl]acetamid, methyl (2R)-2-[[2-[1-[(2-methylphenyl)methyl]-5-oxopyrrolidin-2-yl] acetyl]amino]-3- phenylpropionat, methyl (2R)-2-[[2-[1-[(4-isopropylphenyl)methyl]-5-oxopyrrolidin-2- yl]acetyl]amino]-3-phenylpropionat, N',N'-dimethyl-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin -2- yl]acetohydrazid, N-benzhydryl-2-[1-[(4-ethylphenyl)methyl]-5-oxopyrrolidin-2- yl]acetamid, ethyl 1- [2-[1-[(4-ethylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]pi peridine-2-carboxylat, 4-methyl-2-[[2-[1- [(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]p entancarbonsäure, 2-[(2R)-1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-methyl-N-pheny lacetamid, N-cyclopropyl-2-[(2S)-1- [(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, N-ethyl-2-[1-[(4-methylphenyl)methyl]-5- oxopyrrolidin-2-yl]acetamid, N-methyl-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl] acetamid, N-(isochinolin-5-ylmethyl)-2-[1-[(4-methylphenyl)methyl]-5-o xopyrrolidin-2-yl]acetamid, N- (cyclohexylmethyl)-2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyr rolidin-2-yl]acetamid, (2S)-2-[[(2R)-2- [[2-[1-[(2-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl] amino]-3-phenylpropanoyl]amino]-3- phenylpropionsäure, N-[2-(4-fluorphenyl)ethyl]-2-[1-[(4-methylphenyl)methyl]-5-o xopyrrolidin-2- yl]acetamid, N-benzhydryl-2-[1-[(3-methylphenyl)methyl]-5-oxopyrrolidin-2 -yl]acetamid, 2-[(2S)-1- [(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-methyl-N -phenylacetamid, 2-[1-[(2- fluorphenyl)methyl]-5-oxo-3-phenylpyrrolidin-2-yl]-N-methyls ulfonylacetamid, 1-[(2- chlorphenyl)methyl]-5-[2-[2-(3,4-dichlorphenyl)azepan-1-yl]- 2-oxoethyl]pyrrolidin-2-on, methyl 2-[[2- [(2R)-1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]ace tyl]-methylamino]acetat, 2-[1-[(4- ethylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-methyl-N-phenyla cetamid, N-(2-methoxyethyl)-2-[1-[(4- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, ethyl 1-[2-[(2S)-1-[(2,3-difluorphenyl)methyl]-5- oxopyrrolidin-2-yl]acetyl]piperidine-2-carboxylat, (2S)-4-methyl-2-[[2-[1-[(2-methylphenyl)methyl]-5- oxopyrrolidin-2-yl]acetyl]amino]pentancarbonsäure, N-allyl-2-[1-[(4-methylphenyl)methyl]-5- oxopyrrolidin-2-yl]acetamid, 2-[1-[(2,4-dichlorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(2- methoxyethyl)acetamid, 2-[1-[(4-tert-butylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-[( 4- fluorphenyl)methyl]acetamid, N-cyclohexyl-2-[5-oxo-1-[[3-(trifluormethyl)phenyl]methyl]-p yrrolidin- 2-yl]acetamid, N-[2-(2-bromphenyl)ethyl]-2-[1-[(4-methylphenyl)methyl]-5-ox opyrrolidin-2- yl]acetamid, 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-[2-[3- (trifluormethoxy)phenyl]ethyl]acetamid, N-benzhydryl-2-[1-[(2-ethylphenyl)methyl]-5-oxopyrrolidin-2- yl]acetamid, 2-[1-[(2-ethylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(1-meth yl-1H-1,2,4-triazol-5- yl)acetamid, (2R)-3-(1H-indol-3-yl)-2-[[2-[1-[(4-methylphenyl)methyl]-5-o xopyrrolidin-2- yl]acetyl]amino]propionsäure, (2S)-2-[[2-[(2R)-1-[(2-ethylphenyl)methyl]-5-oxopyrrolidin-2 - yl]acetyl]amino]-3-phenylpropionsäure, N-benzhydryl-2-[(2R)-1-[(2,3-difluorphenyl)methyl]-5- oxopyrrolidin-2-yl]acetamid, N-[2-(1H-indol-3-yl)ethyl]-2-[1-[(4-methylphenyl)methyl]-5- oxopyrrolidin-2-yl]acetamid, 2-[5-oxo-1-[[4-(trifluormethyl)phenyl]methyl]pyrrolidin-2-yl ]essigsäure, methyl 2-[[2-[1-[(4-ethylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl ]-methylamino]acetat, N-[3- (diethylamino)propyl]-2-[1-[(2,3-difluorphenyl)methyl]-5-oxo pyrrolidin-2-yl]acetamid, 2-[1-[(2- ethylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-methylsulfonylac etamid, (2S)-2-[[2-[(2S)-1-[(2- ethylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-3-phe nylpropionsäure, 2-[1-[(4- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(chinolin-6-ylm ethyl)acetamid, N-[(2,4- difluorphenyl)methyl]-2-[1-[(2,3-difluorphenyl)methyl]-5-oxo pyrrolidin-2-yl]acetamid, 2-[1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-[2-(5-hydroxy- 1H-indol-3-yl)ethyl]acetamid, methyl 4- [[2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl] amino]butyrat, tert-butyl (2S)-3-(4- hydroxyphenyl)-2-[[2-[1-[(4-methylphenyl)methyl]-5-oxopyrrol idin-2-yl]acetyl]amino]propionat, N- [(2-fluorphenyl)methyl]-2-[5-oxo-1-[[3-(trifluormethyl)pheny l]methyl]pyrrolidin-2-yl]acetamid, [(1S,2R,5R)-2-isopropyl-5-methylcyclohexyl] 2-[(2S)-1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2- yl]acetat, ethyl 1-[2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl ]piperidine-2-carboxylat, 2-[[2-[1-[(4-ethylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl ]-methylamino]essigsäure, N-methyl-2-[1- [(2-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-phenylaceta mid, 2-[1-[(2,3-difluorphenyl)methyl]-5- oxopyrrolidin-2-yl]-N-phenylacetamid, methyl 2-[methyl-[2-[1-[(3-methylphenyl)methyl]-5- oxopyrrolidin-2-yl]acetyl]amino]acetat, (2R)-2-[[2-[(2S)-1-[(2-ethylphenyl)methyl]-5-oxopyrrolidin-2 - yl]acetyl]amino]-4-methylpentancarbonsäure, N-cyclopropyl-2-[(2R)-1-[(2,3-difluorphenyl)methyl]-5- oxopyrrolidin-2-yl]acetamid, N-cyclopropyl-2-[1-[(3-methylphenyl)methyl]-5-oxopyrrolidin- 2- yl]acetamid, (2R,3R)-2-[[2-[1-[(4-isopropylphenyl)methyl]-5-oxopyrrolidin -2-yl]acetyl]amino]-3- methylpentancarbonsäure, 2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-[2- [3- (trifluormethyl)phenyl]-ethyl]acetamid, N-[2-(diethylamino)ethyl]-2-[1-[(2,3-difluorphenyl)methyl]-5 - oxopyrrolidin-2-yl]acetamid, N-[(2,4-difluorphenyl)methyl]-2-[1-[(4-methylphenyl)methyl]- 5- oxopyrrolidin-2-yl]acetamid, N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-2-[1-[(4-methylphenyl)m ethyl]-5- oxopyrrolidin-2-yl]acetamid, N-benzhydryl-2-[1-[(2-methylphenyl)methyl]-5-oxopyrrolidin-2 - yl]acetamid, (2R,3R)-2-[[2-[1-[(4-ethylphenyl)methyl]-5-oxopyrrolidin-2-y l]acetyl]amino]-3- methylpentancarbonsäure, N-[(1-ethyl-1H-pyrazol-3-yl)methyl]-2-[1-[(4-methylphenyl)me thyl]-5- oxopyrrolidin-2-yl]acetamid, N-[2-(diethylamino)ethyl]-2-[1-[(4-methylphenyl)methyl]-5- oxopyrrolidin-2-yl]acetamid, (2S,3S)-3-methyl-2-[[2-[(2S)-1-[(3-methylphenyl)methyl]-5- oxopyrrolidin-2-yl]acetyl]-amino]pentancarbonsäure, N-cyclopropyl-2-[1-[(2-methylphenyl)methyl]-5- oxopyrrolidin-2-yl]acetamid, N-[2-(3,5-dimethoxyphenyl)ethyl]-2-[1-[(4-methylphenyl)methy l]-5- oxopyrrolidin-2-yl]acetamid, 2-[5-oxo-3-phenyl-1-(pyridin-3-ylmethyl)pyrrolidin-2-yl]essi gsäure, ethyl 1-[2-[1-[(2-ethylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl] piperidine-2-carboxylat, methyl 2-[[2-[1- [(6-chlorpyridin-3-yl)methyl]-5-oxopyrrolidin-2-yl]acetyl]-m ethylamino]acetat, 2-[1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(isochinolin-5 -ylmethyl)acetamid, 2-[1-[(6-chlorpyridin- 3-yl)methyl]-5-oxopyrrolidin-2-yl]-N-methyl-N-phenylacetamid , N-cyclopropyl-2-[1-[(4- ethylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, N-benzhydryl-2-[1-[(4-isopropylphenyl)methyl]-5- oxopyrrolidin-2-yl]acetamid, ethyl 1-[2-[1-[(2-methylphenyl)methyl]-5-oxopyrrolidin-2- yl]acetyl]piperidine-2-carboxylat, 2-[5-oxo-1-[[5-(trifluormethyl)pyridin-2-yl]methyl]pyrrolidi n-2- yl]essigsäure, 2-[[2-[(2S)-1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2- yl]acetyl]- methylamino]essigsäure, ethyl 2-(1-benzyl-5-oxopyrrolidin-2-yl)propionat, N-(cyclohexylmethyl)-2-[1- [(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, ethyl 1-[2-[1-[(6-chlorpyridin-3-yl)methyl]-5- oxopyrrolidin-2-yl]acetyl]piperidine-2-carboxylat, N-benzhydryl-2-[1-[(2,3-difluorphenyl)methyl]-5- oxopyrrolidin-2-yl]acetamid, N-(3-methylbutyl)-2-[1-[(4-methylphenyl)methyl]-5-oxopyrroli din-2- yl]acetamid, N-cyclopropyl-2-[1-[(4-isopropylphenyl)methyl]-5-oxopyrrolid in-2-yl]acetamid, 2-[1-[(4- isopropylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-methylsulfon ylacetamid, 2-[1-[(5-methoxypyridin-2- yl)methyl]-5-oxopyrrolidin-2-yl]essigsäure, 2-[5-oxo-1-[[2-(trifluormethyl)phenyl]methyl]pyrrolidin-2- yl]essigsäure, 2-[1-[[3-fluor-4-(trifluormethyl)phenyl]methyl]-5-oxopyrroli din-2-yl]essigsäure, 2-[1-[[5- fluor-2-(trifluormethyl)phenyl]methyl]-5-oxopyrrolidin-2-yl] essigsäure, 2-[5-oxo-1-[[4-(2,2,2- trifluorethoxy)phenyl]methyl]pyrrolidin-2-yl]essigsäure, N-methylsulfonyl-2-[5-oxo-3-phenyl-1- (pyridin-2-ylmethyl)pyrrolidin-2-yl]acetamid, N-[3-(diethylamino)propyl]-2-[1-[(4- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, 2-[1-[(3,4-difluorphenyl)methyl]-5-oxo-3- phenylpyrrolidin-2-yl]-N-methylsulfonylacetamid, 2-[5-oxo-1-(pyridin-2-ylmethyl)pyrrolidin-2- yl]propionsäure, 2-[1-[[3-chlor-5-(trifluormethyl)pyridin-2-yl]methyl]-5-oxop yrrolidin-2-yl]essigsäure, 2-(1-benzyl-5-oxopyrrolidin-2-yl)propionsäure, 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]- N-(chinolin-5-ylmethyl)acetamid, 2-[1-[(6-chlorpyridin-3-yl)methyl]-5-oxopyrrolidin-2-yl]-N- cyclopropylacetamid, N-methylsulfonyl-2-[5-oxo-3-phenyl-1-(pyridin-3-ylmethyl)pyr rolidin-2- yl]acetamid, methyl (2R)-2-[[2-[1-[(4-ethylphenyl)methyl]-5-oxopyrrolidin-2-yl]a cetyl]amino]-3- phenylpropionat, 2-[1-[(3-fluorphenyl)methyl]-5-oxo-3-phenylpyrrolidin-2-yl]- N- methylsulfonylacetamid, 2-[[2-[1-[(2-ethylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl ]- methylamino]essigsäure, N-methyl-2-[1-[(3-methylphenyl)methyl]-5-oxopyrrolidin-2-yl] -N- phenylacetamid, 2-[1-[(3-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-methyl sulfonylacetamid, methyl 2-[[2-[1-[(4-isopropylphenyl)methyl]-5-oxopyrrolidin-2-yl]ac etyl]-methylamino]acetat, 2-[1-[(2- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(1-methyl-1H-1, 2,4-triazol-5-yl)acetamid, 2-[1-[(4- ethylphenyl)methyl]-5-oxopyrrolidin-2-yl]essigsäure, 2-[1-[(2-ethylphenyl)methyl]-5-oxopyrrolidin-2- yl]essigsäure, 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]propions ure, 2-[1-[(4- fluorphenyl)methyl]-5-oxo-3-phenylpyrrolidin-2-yl]-N-methyls ulfonylacetamid, 2-[1-[(2,6- difluorphenyl)methyl]-5-oxo-3-phenylpyrrolidin-2-yl]-N-methy lsulfonylacetamid, 2-[1-[(3,4- difluorphenyl)methyl]-5-oxo-3-phenylpyrrolidin-2-yl]essigsä ure, methyl 2-[1-[(4- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]propionate, 2-[1-[(2,3-difluorphenyl)methyl]-5- oxopyrrolidin-2-yl]-N-[2-(4-fluorphenyl)ethyl]acetamid, 2-[1-[(2,3-difluorphenyl)methyl]-5-oxo-3- phenylpyrrolidin-2-yl]essigsäure, 2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-[2- (5- methoxy-1H-indol-3-yl)ethyl]acetamid, 2-[1-[(6-chlorpyridin-3-yl)methyl]-5-oxopyrrolidin-2-yl]-N- methylsulfonylacetamid, 2-[1-[(6-chlorpyridin-3-yl)methyl]-5-oxopyrrolidin-2-yl]-N-( 1-methyl-1H- 1,2,4-triazol-5-yl)acetamid, (2S,3S)-2-[[2-[1-[(6-chlorpyridin-3-yl)methyl]-5-oxopyrrolid in-2- yl]acetyl]amino]-3-methylpentancarbonsäure, 2-[1-[(6-chlorpyridin-3-yl)methyl]-5-oxopyrrolidin-2- yl]essigsäure, N-benzhydryl-2-[1-[(6-chlorpyridin-3-yl)methyl]-5-oxopyrroli din-2-yl]acetamid, 2-[1-[(4- isopropylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-methyl-N-phe nylacetamid, ethyl 1-[2-[1-[(4- isopropylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]piperidi ne-2-carboxylat, 2-[1-[(4- isopropylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(1-methyl-1H -1,2,4-triazol-5-yl)acetamid, methyl 2- [[2-[1-[(2-ethylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]- methylamino]acetat, methyl 2-[methyl-[2- [1-[(2-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amin o]acetat, 2-[[2-[1-[(4- isopropylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]-methyla mino]essigsäure, 2-[1-[(2- ethylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-methyl-N-phenyla cetamid, 2-[1-[(4-ethylphenyl)methyl]- 5-oxopyrrolidin-2-yl]-N-(1-methyl-1H-1,2,4-triazol-5-yl)acet amid, ethyl 1-[2-[1-[(3- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]piperidine- 2-carboxylat, 5-[2-[4-(4- chlorphenyl)piperazin-1-yl]-2-oxoethyl]-1-[(2,4-dichlorpheny l)methyl]pyrrolidin-2-on, N-cyclohexyl-2- [1-[(2,4-dichlorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid , 1-[(2,4-dichlorphenyl)methyl]-5-(2-oxo- 2-piperidin-1-ylethyl)pyrrolidin-2-on, 2-[1-[(4-tert-butylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(2 - pyrrolidin-1-ylethyl)acetamid, 2-[1-[(4-tert-butylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(2 -pyridin-2- ylethyl)acetamid, 1-[(4-tert-butylphenyl)methyl]-5-[2-[2-(4-methoxyphenyl)azep an-1-yl]-2- oxoethyl]pyrrolidin-2-on, 2-[1-[(2,4-dichlorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(2- ethylbutyl)acetamid, 5-[2-[2-(3,4-dichlorphenyl)azepan-1-yl]-2-oxoethyl]-1-[[3- (trifluormethyl)phenyl]methyl]pyrrolidin-2-on, 1-[(2,4-difluorphenyl)methyl]-5-[2-(2- isopropylpyrrolidin-1-yl)-2-oxoethyl]pyrrolidin-2-on, 5-[2-[2-(3,4-dichlorphenyl)azepan-1-yl]-2- oxoethyl]-1-[(4-phenylphenyl)methyl]-pyrrolidin-2-on, N,N-dibenzyl-2-[5-oxo-1-(pyridin-2- ylmethyl)pyrrolidin-2-yl]acetamid, Benzyl-N-[2-[[2-[5-oxo-1-[[3- (trifluormethyl)phenyl]methyl]pyrrolidin-2-yl]acetyl]amino]- ethyl]carbamat, 1-[(4-tert- butylphenyl)methyl]-5-[2-oxo-2-(4-pyridin-2-ylpiperazin-1-yl )ethyl]pyrrolidin-2-on, N-(2- bicyclo[2.2.1]heptanyl)-2-[5-oxo-1-(pyridin-2-ylmethyl)pyrro lidin-2-yl]acetamid, 2-[1-[(4-tert- butylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-[(1R)-1-cyclohex ylethyl]acetamid, 2-[1-[(2,4- dichlorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-ethyl-N-propyl acetamid, 1-[(2-chlorphenyl)methyl]-5- [2-[2-(2-methylpropyl)pyrrolidin-1-yl]-2-oxoethyl]pyrrolidin -2-on, 1-[(4-tert-butylphenyl)methyl]-5-[2- (2,6-dimethylmorpholin-4-yl)-2-oxoethyl]pyrrolidin-2-on, 1-benzyl-5-[2-[2-(3,4- dichlorphenyl)pyrrolidin-1-yl]-2-oxoethyl]pyrrolidin-2-on, 2-[5-oxo-1-[(4- phenylphenyl)methyl]pyrrolidin-2-yl]-N-pentylacetamid, N-(2-bicyclo[2.2.1]heptanyl)-2-[1-[(2,4- dichlorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, 5-[2-(1,2,3,4,4a,5,6,7,8,8a-decahydroisochinolin- 2-yl)-2-oxoethyl]-1-[(4-methylphenyl)methyl]pyrrolidin-2-on, 5-[2-(2-ethylpiperidin-1-yl)-2-oxoethyl]- 1-[(4-phenylphenyl)methyl]pyrrolidin-2-on, 5-[2-oxo-2-(2-propylpyrrolidin-1-yl)ethyl]-1-[(4- phenylphenyl)methyl]pyrrolidin-2-on, N-(cyclohexylmethyl)-2-[1-[(2,4-dichlorphenyl)methyl]-5- oxopyrrolidin-2-yl]acetamid, 2-[1-[(2,4-dichlorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(2, 3- dimethylcyclohexyl)acetamid, 1-benzyl-5-(2-isoindolin-2-yl-2-oxoethyl)pyrrolidin-2-on, N,N-dibenzyl- 2-[1-[(2,4-dichlorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetam id, 1-[(2,4-difluorphenyl)methyl]-5-[2-[2- (3-methoxyphenyl)azepan-1-yl]-2-oxoethyl]pyrrolidin-2-on, N-(2,3-dimethylcyclohexyl)-2-[5-oxo-1- [(4-phenylphenyl)methyl]-pyrrolidin-2-yl]acetamid, 5-[2-[2-(3,4-dichlorphenyl)pyrrolidin-1-yl]-2- oxoethyl]-1-[[3-(trifluormethyl)phenyl]methyl]pyrrolidin-2-o n, 2-[1-[(4-tert-butylphenyl)methyl]-5- oxopyrrolidin-2-yl]-N-(2-ethylhexyl)acetamid, N-(2-bicyclo[2.2.1]heptanyl)-2-[1-[(2,4- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, 5-[2-[2-(3,4-dichlorphenyl)azepan-1-yl]-2- oxoethyl]-1-[(2,4-difluorphenyl)methyl]pyrrolidin-2-on, N-[(1R)-1-cyclohexylethyl]-2-[5-oxo-1-[(1R)- 1-phenylethyl]pyrrolidin-2-yl]acetamid, N-benzyl-2-(1-benzyl-5-oxopyrrolidin-2-yl)-N-methylacetamid, 2-(1-benzyl-5-oxopyrrolidin-2-yl)-N-(pyridin-2-ylmethyl)acet amid, N,N-diethyl-1-[2-[5-oxo-1-[[3- (trifluormethyl)phenyl]methyl]pyrrolidin-2-yl]acetyl]piperid ine-3-carboxamid, 2-[1-[(2,4- dichlorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-[(2-methylphen yl)methyl]acetamid, 2-[1-[(4-tert- butylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(2-morpholin-4-y lethyl)acetamid, 2-[1-[(4-tert- butylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-[(2-fluorphenyl) methyl]acetamid, 1-[(2,4- difluorphenyl)methyl]-5-[2-(3,5-dimethylpiperidin-1-yl)-2-ox oethyl]pyrrolidin-2-on, 1-[(2,4- dichlorphenyl)methyl]-5-(2-morpholin-4-yl-2-oxoethyl)pyrroli din-2-on, 2-[1-[(2,4- dichlorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-pentan-3-ylace tamid, 2-[1-[(2,4-dichlorphenyl)methyl]- 5-oxopyrrolidin-2-yl]-N-(3,3-dimethylbutyl)acetamid, 1-[(4-tert-butylphenyl)methyl]-5-(2-oxo-2- thiomorpholin-4-ylethyl)pyrrolidin-2-on, N-ethyl-2-[5-oxo-1-[[3-(trifluormethyl)- phenyl]methyl]pyrrolidin-2-yl]acetamid, 1-benzyl-5-(2-oxo-2-thiomorpholin-4-ylethyl)pyrrolidin-2-on, 5-[2-[4-(4-chlorphenyl)piperazin-1-yl]-2-oxoethyl]-1-[(1R)-1 -phenylethyl]pyrrolidin-2-on, 2-[1-[(4-tert- butylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(5-methylhexan-2 -yl)acetamid, 2-[1-[(2- chlorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-cyclohexylacetam id, 2-[1-[(2-chlorphenyl)methyl]-5- oxopyrrolidin-2-yl]-N,N-dimethylacetamid, N-benzyl-2-[1-[(2,4-dichlorphenyl)methyl]-5- oxopyrrolidin-2-yl]acetamid, 2-[1-[(4-tert-butylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N- cyclopentylacetamid, N-[(4-fluorphenyl)methyl]-2-[5-oxo-1-[[3- (trifluormethyl)phenyl]methyl]pyrrolidin-2-yl]acetamid, 1-[(2,4-dichlorphenyl)methyl]-5-[2-oxo-2-[4- (pyridin-2-ylmethyl)piperazin-1-yl]ethyl]pyrrolidin-2-on, 2-[1-[(2,4-difluorphenyl)methyl]-5- oxopyrrolidin-2-yl]-N-(3,3,5-trimethylcyclohexyl)acetamid, 2-[1-[(2-chlorphenyl)methyl]-5- oxopyrrolidin-2-yl]-N-[3-(dimethylamino)propyl]acetamid, 2-[1-[(2,4-dichlorphenyl)methyl]-5- oxopyrrolidin-2-yl]-N-(2-phenylethyl)acetamid, N-benzyl-2-[1-[(2,4-dichlorphenyl)methyl]-5- oxopyrrolidin-2-yl]-N-methylacetamid, 1-[(4-tert-butylphenyl)methyl]-5-(2-oxo-2-pyrrolidin-1- ylethyl)pyrrolidin-2-on, 2-[1-[(4-tert-butylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(o xolan-2- ylmethyl)acetamid, 2-[1-[(4-tert-butylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-[( 2- chlorphenyl)methyl]acetamid, 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(2-pyr rolidin-1- ylethyl)acetamid, 2-[1-[(2,4-dichlorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-[3- (1H-imidazol-1- yl)propyl]acetamid, 2-[1-[(2,4-dichlorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-[2- (dimethylamino)ethyl]-N-methylacetamid, 1-[(4-tert-butylphenyl)methyl]-5-(2-oxo-2-piperidin-1- ylethyl)pyrrolidin-2-on, (2S)-2-[[2-[1-[(4-ethylphenyl)methyl]-5-oxopyrrolidin-2-yl]a cetyl]amino]-4- methylpentancarbonsäure, (2R,3R)-2-[[2-[1-[(2-ethylphenyl)methyl]-5-oxopyrrolidin-2- yl]acetyl]amino]-3-methylpentancarbonsäure, methyl (2S)-3-(1H-imidazol-4-yl)-2-[[2-[(2R)-1-[(4- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]propi onat, (2S)-2-[[2-[(2R)-1-[(4- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-3-ph enylpropionsäure, 2-[[2-[(2R)-1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]-methylami no]essigsäure, N-(2- bicyclo[2.2.1]heptanyl)-2-[5-oxo-1-(pyridin-2-ylmethyl)pyrro lidin-2-yl]acetamid, 2-[1-[(4-tert- butylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-[(1S)-1-cyclohex ylethyl]acetamid, 2-[1-[(4- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(2-phenylethyl) acetamid, 2-[1-[(4- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(2-pyridin-3-yl ethyl)acetamid, N-[2-(2- methoxyphenyl)ethyl]-2-[1-[(4-methylphenyl)methyl]-5-oxopyrr olidin-2-yl]acetamid, 2-[1-[(4- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(2-pyridin-2-yl ethyl)acetamid, 2-[1-[(4- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-[2-[3-(trifluor methyl)phenyl]ethyl]acetamid, 2-[1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-[2-[4-(trifluo rmethoxy)phenyl]ethyl]acetamid, N-[2-(3- bromphenyl)ethyl]-2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrr olidin-2-yl]acetamid, N-[2-(2,5- dichlorphenyl)ethyl]-2-[1-[(2,3-difluorphenyl)methyl]-5-oxop yrrolidin-2-yl]acetamid, 2-[1-[(2,3- difluor-phenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(2-thiophen-2 -ylethyl)acetamid, 2-[5-oxo-1-(pyridin-3- ylmethyl)pyrrolidin-2-yl]propionsäure, Methyl 2-[5-oxo-1-(pyridin-3-ylmethyl)pyrrolidin-2-yl]acetat, Methyl 2-[5-oxo-1-(pyridin-3-ylmethyl)pyrrolidin-2-yl]propionat, 2-[1-[(4-fluorphenyl)methyl]-5- oxopyrrolidin-2-yl]propionsäure, N-[2-(3,4-dimethoxyphenyl)ethyl]-2-[1-[(4-methylphenyl)methy l]-5- oxopyrrolidin-2-yl]acetamid, 2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-[2- (2- methoxyphenyl)ethyl]acetamid, 2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-[2- (3,4- imethoxyphenyl)ethyl]-acetamid, 2-[1-[(4-fluorphenyl)methyl]-5-oxo-3-phenylpyrrolidin-2- yl]essigsäure, 2-[1-[(2-fluorphenyl)methyl]-5-oxopyrrolidin-2-yl]propionsä ure, 2-(1-benzyl-5-oxo-3- phenylpyrrolidin-2-yl)-N-methylsulfonylacetamid, 2-[1-[(2,4-difluorphenyl)methyl]-5-oxo-3- phenylpyrrolidin-2-yl]-N-methylsulfonylacetamid, methyl 4-[[2-[1-[(2,3-difluorphenyl)-methyl]-5- oxopyrrolidin-2-yl]acetyl]amino]butyrat, N-[2-(4-chlorphenyl)ethyl]-2-[1-[(2,3-difluorphenyl)methyl]- 5-oxopyrrolidin-2-yl]acetamid, 2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(2- pyridin-3- ylethyl)acetamid, N-[2-(2,5-dichlorphenyl)ethyl]-2-[1-[(4-methylphenyl)methyl] -5-oxopyrrolidin-2- yl]acetamid, 2-[1-[(3-fluorphenyl)methyl]-5-oxo-3-phenylpyrrolidin-2-yl]e ssigsäure, methyl 2-[1-[(3,4- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]propionat, methyl 2-[1-[(3-fluorphenyl)methyl]-5- oxopyrrolidin-2-yl]propionat, 2-[1-[(2,4-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]propio nsäure, 2-[1- [(3,4-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]propionsäu re, 2-[1-[(3-fluorphenyl)methyl]-5- oxopyrrolidin-2-yl]propionsäure, 2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]propio nsäure, 2-[1-[(2,6-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]propio nsäure, 2-(1-benzyl-5-oxo-3- phenylpyrrolidin-2-yl)essigsäure, N-[2-[3-chlor-5-(trifluormethyl)pyridin-2-yl]ethyl]-2-[1-[(4 - methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, N-[2-[3-chlor-5-(trifluormethyl)pyridin-2- yl]ethyl]-2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2 -yl]acetamid, 2-[1-[1-(3,5- difluorphenyl)ethyl]-5-oxopyrrolidin-2-yl]essigsäure, 2-[1-[(2,3-difluorphenyl)methyl]-5-oxo-3- phenylpyrrolidin-2-yl]-N-methylsulfonylacetamid, methyl 2-[1-[(2,4-difluorphenyl)methyl]-5- oxopyrrolidin-2-yl]acetat, methyl 2-[1-[(2,6-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]propio nat, N- [2-(2,4-difluorphenyl)ethyl]-2-[1-[(4-methylphenyl)methyl]-5 -oxopyrrolidin-2-yl]acetamid, N-[2-(3- bromphenyl)ethyl]-2-[1-[(4-methylphenyl)methyl]-5-oxopyrroli din-2-yl]acetamid, 2-[1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-[2-(4-methoxyp henyl)ethyl]acetamid, methyl 2-[5-oxo- 1-(pyridin-2-ylmethyl)pyrrolidin-2-yl]propionat, 4-[[2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2- yl]acetyl]amino]butyric acid, methyl 2-[5-oxo-1-(pyridin-2-ylmethyl)pyrrolidin-2-yl]acetat, 2-[1-[(2- fluorphenyl)methyl]-5-oxo-3-phenylpyrrolidin-2-yl]essigsäur e, 2-[1-[(2,3-difluorphenyl)methyl]-5- oxopyrrolidin-2-yl]-N-[2-(3-methoxyphenyl)ethyl]acetamid, N-[2-(2,3-dichlorphenyl)ethyl]-2-[1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin- 2-yl]-N-[2-[4-(trifluormethoxy)-phenyl]ethyl]acetamid, methyl 2-[1-[(2-fluorphenyl)methyl]-5- oxopyrrolidin-2-yl]propionat, N-[2-[3,5-bis(trifluormethyl)phenyl]ethyl]-2-[1-[(4- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, N-[2-[3,5-bis(trifluormethyl)phenyl]ethyl]-2-[1- [(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, 2-[1-[(2,3-difluorphenyl)methyl]-5- oxopyrrolidin-2-yl]-N-[2-(4-methylphenyl)ethyl]acetamid, methyl 2-[1-[(4-fluorphenyl)methyl]-5- oxopyrrolidin-2-yl]propionat, methyl 2-[1-[(2,4-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]propio nat, methyl 2-[1-[(2,6-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat , 2-[1-[(2,4-difluorphenyl)methyl]- 5-oxo-3-phenylpyrrolidin-2-yl]essigsäure, 2-[1-[(4-methylphenyl)-methyl]-5-oxo-3-phenylpyrrolidin-2- yl]essigsäure, N-[2-(3-methoxyphenyl)ethyl]-2-[1-[(4-methylphenyl)methyl]-5 -oxopyrrolidin-2- yl]acetamid, N-[2-(3-chlorphenyl)ethyl]-2-[1-[(2,3-difluorphenyl)methyl]- 5-oxopyrrolidin-2- yl]acetamid, N-[2-(3-chlorphenyl)ethyl]-2-[1-[(4-methylphenyl)methyl]-5-o xopyrrolidin-2-yl]acetamid, N-[2-(4-methoxyphenyl)ethyl]-2-[1-[(4-methylphenyl)methyl]-5 -oxopyrrolidin-2-yl]acetamid, N-[2-(2- chlorphenyl)ethyl]-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrol idin-2-yl]acetamid, N-[2-(4- methylphenyl)ethyl]-2-[1-[(4-methylphenyl)methyl]-5-oxopyrro lidin-2-yl]acetamid, N-[2-(2- chlorphenyl)ethyl]-2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyr rolidin-2-yl]acetamid, 2-[1-[(2,3- difluorphenyl)-methyl]-5-oxopyrrolidin-2-yl]-N-(2-pyridin-2- ylethyl)acetamid, N-[2-(2,4- dichlorphenyl)-ethyl]-2-[1-[(2,3-difluorphenyl)methyl]-5-oxo pyrrolidin-2-yl]acetamid, N-[2-(4- chlorphenyl)ethyl]-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrol idin-2-yl]acetamid, 2-[1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-[2-(3-fluorphe nyl)ethyl]acetamid, N-[2-(2,4- dichlorphenyl)ethyl]-2-[1-[(4-methylphenyl)methyl]-5-oxopyrr olidin-2-yl]acetamid, N-[2-(3- fluorphenyl)ethyl]-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrol idin-2-yl]acetamid, 2-[1-[(4- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(2-thiophen-2-y lethyl)acetamid, (2R)-2-[[2-[1-[(4- ethylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-3-phe nylpropionsäure, 2-(1-benzyl-5- oxopyrrolidin-2-yl)-N-(oxolan-2-ylmethyl)acetamid, 2-(1-benzyl-5-oxopyrrolidin-2-yl)-N- cyclohexylacetamid, N-(2,2-difluorethyl)-2-[1-[(4-methylphenyl)methyl]-5-oxopyrr olidin-2- yl]acetamid, N-(2,2-difluorethyl)-2-[1-[(2,3-difluorphenyl)methyl]-5-oxop yrrolidin-2-yl]acetamid, [5- Oxo-1-(2,3,6-trifluorbenzyl)pyrrolidin-2-yl]essigsäure, [5-Oxo-1-(2,3,4-trifluorbenzyl)pyrrolidin-2- yl]essigsäure, [5-Oxo-1-(2,3,5-trifluorbenzyl)pyrrolidin-2-yl]essigsäure, [5-Oxo-1-(2,3- dimethylbenzyl)pyrrolidin-2-yl]essigsäure, N-[(4-chlorphenyl)methyl]-1-(2-methylpropyl)-5- oxopyrrolidine-3-carboxamid, 1-benzyl-5-oxo-N-[[3-(trifluormethyl)phenyl]methyl]pyrrolidi ne-3- carboxamid, N-[(2,3-dichlorphenyl)methyl]-5-oxo-1-phenylpyrrolidine-3-ca rboxamid, 1-[2-(4- chlorphenyl)ethyl]-N-[(3,5-dimethoxyphenyl)methyl]-5-oxopyrr olidine-3-carboxamid, N-[(3,5- dichlorphenyl)methyl]-5-oxo-1-prop-2-yn-1-ylpyrrolidine-3-ca rboxamid, 1-[(4-chlorphenyl)methyl]-5- oxo-N-(pyridin-3-ylmethyl)pyrrolidin-3-carboxamid, 1-benzyl-N-[(5-methylpyrazin-2-yl)methyl]-5- oxopyrrolidine-3-carboxamid, 1-(1,3-benzodioxol-5-ylmethyl)-N-[(2,3-dichlorphenyl)methyl] -5- oxopyrrolidine-3-carboxamid, 1-benzyl-N-methyl-5-oxo-N-(pyridin-4-ylmethyl)pyrrolidine-3- carboxamid, 1-[(4-chlorphenyl)methyl]-N-[(2-methoxyphenyl)methyl]-N-meth yl-5-oxopyrrolidine-3- carboxamid, 1-(4-methylphenyl)-5-oxo-N-(pyridin-2-ylmethyl)pyrrolidine-3 -carboxamid, N-[(4- methoxyphenyl)methyl]-1-(2-methylpropyl)-5-oxopyrrolidin-3-c arboxamid, 1-benzyl-N-[(2,3- dichlorphenyl)methyl]-5-oxopyrrolidin-3-carboxamid, N-benzyl-1-(2-methylpropyl)-5-oxopyrrolidine- 3-carboxamid, 1-benzyl-N-[(2,5-dichlorphenyl)methyl]-5-oxopyrrolidin-3-car boxamid, N-[(2- chlorphenyl)methyl]-1-(2-methylpropyl)-5-oxopyrrolidin-3-car boxamid, N-[(2,4-dichlorphenyl)methyl]- 1-(2-methylpropyl)-5-oxopyrrolidin-3-carboxamid, N-[(3-chlor-4-fluorphenyl)methyl]-1-ethyl-5- oxopyrrolidin-3-carboxamid, 1-(3,5-dimethylphenyl)-5-oxo-N-(pyridin-2-ylmethyl)pyrrolidi ne-3- carboxamid, 1-[2-(4-fluorphenyl)ethyl]-5-oxo-N-(pyridin-3-ylmethyl)pyrro lidine-3-carboxamid, N- [(2,5-dichlorphenyl)methyl]-5-oxo-1-phenylpyrrolidine-3-carb oxamid, N-[(3,4-dichlorphenyl)methyl]- 1-(2-methylpropyl)-5-oxopyrrolidine-3-carboxamid, 1-cyclopropyl-N-[(4-methylphenyl)methyl]-5- oxopyrrolidine-3-carboxamid, 1-butan-2-yl-N-[(4-methylphenyl)methyl]-5-oxopyrrolidine-3- carboxamid, 1-ethyl-N-[(4-methylphenyl)methyl]-5-oxopyrrolidine-3-carbox amid, 5-oxo-N-[indan-1- yl]-1-[3-(trifluormethyl)phenyl]pyrrolidine-3-carboxamid, N-[(2,3-difluorphenyl)methyl]-1-ethyl-5- oxopyrrolidine-3-carboxamid, 1-butan-2-yl-N-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidine- 3- carboxamid, 1-cyclopropyl-N-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidine -3-carboxamid, N-[(2,3- difluorphenyl)methyl]-1-isopropyl-5-oxopyrrolidine-3-carboxa mid, 1-[3,5-bis(trifluormethyl)phenyl]-5- oxo-N-[[2-(trifluormethoxy)pyridin-4-yl]methyl]pyrrolidine-3 -carboxamid, N-[(2-chlorpyridin-4- yl)methyl]-6-(3,5-dichlorphenyl)-2,4-dimethyl-7-oxo-6-azabic yclo[3.2.1]oct-3-ene-8-carboxamid, 1- [3,5-bis(trifluormethyl)phenyl]-N-[[2-(ethylamino)pyrimidin- 4-yl]methyl]-5-oxopyrrolidine-3- carboxamid, 1-(4-fluorphenyl)-5-oxo-N-[indan-1-yl]pyrrolidine-3-carboxam id, 1-(2,4-difluorphenyl)-N- [indan-1-yl]-5-oxopyrrolidine-3-carboxamid, N-[(6-chlorpyridin-3-yl)methyl]-1-(4-methoxyphenyl)-5- oxopyrrolidine-3-carboxamid, N-[(2-chlorphenyl)methyl]-1-(2-methoxyphenyl)-5-oxopyrrolidi ne-3- carboxamid, 1-[3-(difluormethoxy)phenyl]-5-oxo-N-[indan-1-yl]pyrrolidine -3-carboxamid, (3RS)-1- (2,4-difluorphenyl)-N-[(1R*)-indan-1-yl]-5-oxopyrrolidine-3- carboxamid, 1-[3-(difluormethyl)phenyl]- 5-oxo-N-[indan-1-yl]pyrrolidine-3-carboxamid, N-[[3-chlor-5-(trifluormethyl)pyridin-2-yl]methyl]-1- [3-(difluormethoxy)phenyl]-5-oxopyrrolidine-3-carboxamid, N-[[3-chlor-5-(trifluormethyl)pyridin-2- yl]methyl]-5-oxo-1-[3-(trifluormethyl)phenyl]pyrrolidine-3-c arboxamid, N,3-dimethyl-5-oxo-1-phenyl- N-[1,2,3,4-tetrahydronaphthalin-1-yl]pyrrolidine-3-carboxami d, 1-butan-2-yl-N-[(3-chlor-4- fluorphenyl)methyl]-5-oxopyrrolidine-3-carboxamid, 1-benzyl-N-[(2-chlorphenyl)methyl]-5- oxopyrrolidine-3-carboxamid, N-[(3-chlor-4-fluorphenyl)methyl]-1-(2-methylpropyl)-5-oxopy rrolidine- 3-carboxamid, N-[(3-chlor-4-fluorphenyl)methyl]-1-isopropyl-5-oxopyrrolidi ne-3-carboxamid, N-[(4- chlorphenyl)methyl]-5-oxo-1-phenylpyrrolidine-3-carboxamid, N-benzyl-5-oxo-1-phenylpyrrolidine-3- carboxamid, N-[(4-chlorphenyl)methyl]-1-(4-methoxyphenyl)-5-oxopyrrolidi ne-3-carboxamid, N- benzyl-1-(4-chlorphenyl)-5-oxopyrrolidine-3-carboxamid, N-[(4-fluorphenyl)methyl]-1-(4- methoxyphenyl)-5-oxopyrrolidine-3-carboxamid, N-benzyl-1-(4-methoxyphenyl)-5-oxopyrrolidine-3- carboxamid, 1-(4-methoxyphenyl)-N-[(4-methoxyphenyl)methyl]-5-oxopyrroli dine-3-carboxamid, N- [(5-chlor-2-methylphenyl)methyl]-1-(4-methoxyphenyl)-5-oxopy rrolidine-3-carboxamid, N-[(2,4- dichlorphenyl)methyl]-5-oxo-1-phenylpyrrolidine-3-carboxamid , N-[(2,4-dichlorphenyl)methyl]-1-(4- methoxyphenyl)-5-oxopyrrolidine-3-carboxamid, 1-(4-methoxyphenyl)-5-oxo-N-(pyridin-2- ylmethyl)pyrrolidine-3-carboxamid, 5-oxo-1-phenyl-N-(pyridin-2-ylmethyl)pyrrolidine-3-carboxami d, N-[(2,3-difluorphenyl)methyl]-1-(2-methoxyphenyl)-5-oxopyrro lidine-3-carboxamid, N-[(2,3- difluorphenyl)methyl]-1-(4-fluorphenyl)-5-oxopyrrolidine-3-c arboxamid, N-[(2-chlorphenyl)methyl]-1- (4-fluorphenyl)-5-oxopyrrolidine-3-carboxamid, 1-cyclopentyl-5-oxo-N-(pyridin-2- ylmethyl)pyrrolidine-3-carboxamid, 1-(4-fluorphenyl)-5-oxo-N-(pyridin-2-ylmethyl)pyrrolidine-3- carboxamid, 1-(4-chlorphenyl)-5-oxo-N-(pyridin-2-ylmethyl)pyrrolidine-3- carboxamid, 1-(4- chlorphenyl)-N-[(2,5-dichlorphenyl)methyl]-5-oxopyrrolidine- 3-carboxamid, 1-(4-chlorphenyl)-N-[(6- chlorpyridin-3-yl)methyl]-5-oxopyrrolidine-3-carboxamid, N-[(2,5-dichlorphenyl)methyl]-1-(2,4- difluorphenyl)-5-oxopyrrolidine-3-carboxamid, N-[[3-chlor-5-(trifluormethyl)pyridin-2-yl]methyl]-1-(2- methylpropyl)-5-oxopyrrolidine-3-carboxamid, N-[[3-chlor-5-(trifluormethyl)pyridin-2-yl]methyl]-1- cyclopentyl-5-oxopyrrolidine-3-carboxamid, 1-(2,4-difluorphenyl)-N-[(2,3-difluorphenyl)methyl]-5- oxopyrrolidine-3-carboxamid, 1-[3-(difluormethoxy)phenyl]-N-[(2,3-difluorphenyl)methyl]-5 - oxopyrrolidine-3-carboxamid, N-[(2,5-dichlorphenyl)-methyl]-5-oxo-1-[3- (trifluormethyl)phenyl]pyrrolidine-3-carboxamid, 1-[3-(difluormethyl)phenyl]-N-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidine-3-carboxamid, N-[(2-chlorphenyl)methyl]-1-[3- (difluormethoxy)phenyl]-5-oxopyrrolidine-3-carboxamid, N-[(2,6-dichlorphenyl)methyl]-1-[3- (difluormethoxy)phenyl]-5-oxopyrrolidine-3-carboxamid, N-[(2,6-dichlorphenyl)methyl]-1-[3- (difluormethyl)phenyl]-5-oxopyrrolidine-3-carboxamid, N-[(2-chlorphenyl)methyl]-1-(2,4- difluorphenyl)-5-oxopyrrolidine-3-carboxamid, N-[(2,6-dichlorphenyl)methyl]-1-(4-fluorphenyl)-5- oxopyrrolidine-3-carboxamid, N-[(2,5-dichlorphenyl)methyl]-1-[3-(difluormethoxy)phenyl]-5 - oxopyrrolidine-3-carboxamid, N-[(2,4-dichlorphenyl)methyl]-1-(2,4-difluorphenyl)-5-oxopyr rolidine-3- carboxamid, N-[(2,5-dichlorphenyl)methyl]-1-[3-(difluormethyl)phenyl]-5- oxopyrrolidine-3- carboxamid, N-[[3-chlor-5-(trifluormethyl)pyridin-2-yl]methyl]-1-(4-fluo rphenyl)-5-oxopyrrolidine-3- carboxamid, N-[(2,4-dichlorphenyl)methyl]-1-(4-fluorphenyl)-5-oxopyrroli dine-3-carboxamid, N-[(2,5- dichlorphenyl)methyl]-1-(4-fluorphenyl)-5-oxopyrrolidine-3-c arboxamid, N-[(2,6- dichlorphenyl)methyl]-1-(2-methoxyphenyl)-5-oxopyrrolidine-3 -carboxamid, N-[(2,6- dichlorphenyl)methyl]-1-(2,4-difluorphenyl)-5-oxopyrrolidine -3-carboxamid, N-[(2- chlorphenyl)methyl]-1-[3-(difluormethyl)phenyl]-5-oxopyrroli dine-3-carboxamid, 1-(4-chlorphenyl)-N- [[3-chlor-5-(trifluormethyl)pyridin-2-yl]methyl]-5-oxopyrrol idine-3-carboxamid, N-[[3-chlor-5- (trifluormethyl)pyridin-2-yl]methyl]-1-cyclobutyl-5-oxopyrro lidine-3-carboxamid, 5-oxo-N-(pyridin-2- ylmethyl)-1-[3-(trifluormethyl)phenyl]pyrrolidine-3-carboxam id, N-[(2,3-difluorphenyl)methyl]-5-oxo- 1-[3-(trifluormethyl)phenyl]pyrrolidine-3-carboxamid, N-[(2,5-dichlorphenyl)methyl]-1-(2- methoxyphenyl)-5-oxopyrrolidine-3-carboxamid, N-[[3-chlor-5-(trifluormethyl)pyridin-2-yl]methyl]-1- (2,4-difluorphenyl)-5-oxopyrrolidine-3-carboxamid, N-[[3-chlor-5-(trifluormethyl)pyridin-2-yl]methyl]- 1-[3-(difluormethyl)phenyl]-5-oxopyrrolidine-3-carboxamid, N-[(6-chlorpyridin-3-yl)methyl]-1-(4- methylphenyl)-5-oxopyrrolidine-3-carboxamid, N-[[3-chlor-5-(trifluormethyl)pyridin-2-yl]methyl]-5- oxo-1-phenylpyrrolidine-3-carboxamid, N-[[3-chlor-5-(trifluormethyl)pyridin-2-yl]methyl]-1-(2- methoxyphenyl)-5-oxopyrrolidine-3-carboxamid, N-[(6-chlorpyridin-3-yl)methyl]-1-cyclopentyl-5- oxopyrrolidine-3-carboxamid, N-[(2,4-dichlorphenyl)methyl]-1-[3-(difluormethoxy)phenyl]-5 - oxopyrrolidine-3-carboxamid, N-[(2-chlorphenyl)methyl]-1-cyclopentyl-5-oxopyrrolidine-3- carboxamid, 1-(2,4-difluorphenyl)-5-oxo-N-(pyridin-2-ylmethyl)pyrrolidin e-3-carboxamid, 1- cyclobutyl-5-oxo-N-(pyrimidin-2-ylmethyl)pyrrolidine-3-carbo xamid, 1-[3-(difluormethyl)phenyl]-5- oxo-N-(pyridin-2-ylmethyl)pyrrolidine-3-carboxamid, 1-[3-(difluormethoxy)phenyl]-5-oxo-N-(pyridin- 2-ylmethyl)pyrrolidine-3-carboxamid, 1-cyclopentyl-5-oxo-N-(pyrimidin-2-ylmethyl)pyrrolidine-3- carboxamid, 1-(2-methylpropyl)-5-oxo-N-(pyrimidin-2-ylmethyl)pyrrolidine -3-carboxamid, N-[(6- chlorpyridin-3-yl)methyl]-1-cyclobutyl-5-oxopyrrolidine-3-ca rboxamid, 1-(2-methylpropyl)-5-oxo-N- (pyridin-2-ylmethyl)pyrrolidine-3-carboxamid, N-[(6-chlorpyridin-3-yl)methyl]-1-(2-methylpropyl)-5- oxopyrrolidine-3-carboxamid, N-[(6-chlorpyridin-3-yl)methyl]-5-oxo-1-phenylpyrrolidine-3- carboxamid, 1-cyclobutyl-5-oxo-N-(pyridin-2-ylmethyl)pyrrolidine-3-carbo xamid, N-[(2- cyclobutyloxypyridin-4-yl)methyl]-1-(3,5-difluorphenyl)-3-me thyl-5-oxopyrrolidine-3-carboxamid, 1- (3,5-difluorphenyl)-3-methyl-5-oxo-N-[[2-(2,2,2-trifluoretho xy)pyridin-4-yl]methyl]pyrrolidine-3- carboxamid, 1-(3,5-difluorphenyl)-3-methyl-N-[(2-methylsulfanylpyrimidin -4-yl)methyl]-5- oxopyrrolidine-3-carboxamid, N-[(2-chlorpyrimidin-4-yl)methyl]-1-(3,5-dichlorphenyl)-3-me thyl-5- oxopyrrolidine-3-carboxamid, 1-(3,5-dichlorphenyl)-N-[[2-(ethylamino)pyrimidin-4-yl]methy l]-3- methyl-5-oxopyrrolidine-3-carboxamid, 1-(3,5-difluorphenyl)-3-methyl-5-oxo-N-[(2-propoxypyridin-4- yl)methyl]pyrrolidin-3-carboxamid, 1-(3,5-dichlorphenyl)-N-[[2-(difluormethoxy)-pyridin-4-yl]me thyl]- 3-methyl-5-oxopyrrolidine-3-carboxamid, 1-(3,5-dichlorphenyl)-N-[(2-ethoxypyrimidin-4-yl)methyl]-3- methyl-5-oxopyrrolidine-3-carboxamid, N-benzyl-6-(3,5-dichlorphenyl)-N,2,4-trimethyl-7-oxo-6- azabicyclo[3.2.1]oct-3-ene-8-carboxamid, 1-(3,5-difluorphenyl)-N-[(2-methoxypyridin-4-yl)methyl]-3- methyl-5-oxopyrrolidine-3-carboxamid, 1-(3,5-dichlorphenyl)-N-[(2-methoxypyridin-4-yl)methyl]-3- methyl-5-oxopyrrolidine-3-carboxamid, 1-(3,5-difluorphenyl)-N-[(2-ethoxypyrimidin-4-yl)methyl]-3- methyl-5-oxopyrrolidine-3-carboxamid, 1-(3,5-difluorphenyl)-N-[(2-ethoxypyridin-4-yl)methyl]-3- methyl-5-oxopyrrolidine-3-carboxamid, 1-(3,5-dichlorphenyl)-N-[(2-ethoxypyridin-4-yl)methyl]-3- methyl-5-oxopyrrolidine-3-carboxamid, 1-(3,5-dichlorphenyl)-3-methyl-N-[[2-(methylamino)pyrimidin- 4-yl]methyl]-5-oxopyrrolidine-3-carboxamid, 1-(3,5-difluorphenyl)-N-[[2-(ethylamino)pyrimidin-4- yl]methyl]-3-methyl-5-oxopyrrolidine-3-carboxamid, 1-(3,5-difluorphenyl)-N-[(2-isopropyloxypyridin- 4-yl)methyl]-3-methyl-5-oxopyrrolidine-3-carboxamid, 1-(3,5-difluorphenyl)-3-methyl-N-[[2- (methylamino)pyrimidin-4-yl]methyl]-5-oxopyrrolidine-3-carbo xamid, 1-(3,5-dichlorphenyl)-N-[(2- ethylsulfanylpyrimidin-4-yl)methyl]-3-methyl-5-oxopyrrolidin e-3-carboxamid, 1-(3,5-dichlorphenyl)- N-[[2-[ethyl(methyl)amino]pyridin-4-yl]methyl]-3-methyl-5-ox opyrrolidine-3-carboxamid, N-[(2- chlorpyrimidin-4-yl)methyl]-1-(3,5-difluorphenyl)-3-methyl-5 -oxopyrrolidine-3-carboxamid, N-[(2- chlorpyridin-4-yl)methyl]-1-(3,5-difluorphenyl)-3-methyl-5-o xopyrrolidine-3-carboxamid, N-[(2- chlorpyridin-4-yl)methyl]-1-(3,5-dichlorphenyl)-3-methyl-5-o xopyrrolidine-3-carboxamid, N-[(2-tert- butoxypyridin-4-yl)methyl]-1-(3,5-difluorphenyl)-3-methyl-5- oxopyrrolidine-3-carboxamid, 1-(3,5- difluorphenyl)-N-[[2-[ethyl(methyl)amino]pyridin-4-yl]methyl ]-3-methyl-5-oxopyrrolidine-3- carboxamid, 1-(3,5-difluorphenyl)-3-methyl-N-[(2-morpholin-4-ylpyridin-4 -yl)methyl]-5- oxopyrrolidine-3-carboxamid, N-[(2-tert-butoxypyridin-4-yl)methyl]-1-(3,5-dichlorphenyl)- 3-methyl-5- oxopyrrolidine-3-carboxamid, 1-(3,5-difluorphenyl)-N-[(2-isopropyloxypyrimidin-4-yl)methy l]-3- methyl-5-oxopyrrolidine-3-carboxamid, N-[[2-(difluormethoxy)pyridin-4-yl]methyl]-1-(3,5- difluorphenyl)-3-methyl-5-oxopyrrolidine-3-carboxamid, 1-(3-chlor-5-methylphenyl)-N-[(2- chlorpyridin-4-yl)methyl]-3-methyl-5-oxopyrrolidine-3-carbox amid, 1-(3,5-dichlorphenyl)-3-methyl-N- [(2-methylsulfanylpyrimidin-4-yl)methyl]-5-oxopyrrolidine-3- carboxamid, N-[(2-chlorpyridin-4- yl)methyl]-3-methyl-5-oxo-1-phenylpyrrolidine-3-carboxamid, 1-(3,5-dichlorphenyl)-3-methyl-5-oxo- N-[(2-propoxypyridin-4-yl)methyl]pyrrolidine-3-carboxamid, N-[(2-cyclobutyloxypyridin-4-yl)methyl]- 1-(3,5-dichlorphenyl)-3-methyl-5-oxopyrrolidine-3-carboxamid , 1-(3,5-difluorphenyl)-N-[(2- ethylsulfanylpyrimidin-4-yl)methyl]-3-methyl-5-oxopyrrolidin e-3-carboxamid, 1-(3,5-dichlorphenyl)- N-[(2-isopropyloxypyridin-4-yl)methyl]-3-methyl-5-oxopyrroli dine-3-carboxamid, 1-(3,5- dichlorphenyl)-N-[(2-isopropyloxypyrimidin-4-yl)methyl]-3-me thyl-5-oxopyrrolidine-3-carboxamid, 1- (3,5-difluorphenyl)-N-[[2-(4-fluorphenoxy)pyridin-4-yl]methy l]-3-methyl-5-oxopyrrolidine-3- carboxamid, 1-(3,5-dichlorphenyl)-N-[[2-(4-fluorphenoxy)pyridin-4-yl]met hyl]-3-methyl-5- oxopyrrolidine-3-carboxamid, N-benzyl-N,2,4-trimethyl-7-oxo-6-(3,4,5-trichlorphenyl)-6- azabicyclo[3.2.1]oct-3-ene-8-carboxamid, N-[[2-(ethylamino)pyrimidin-4-yl]methyl]-2,4-dimethyl-7- oxo-6-(3,4,5-trichlorphenyl)-6-azabicyclo[3.2.1]oct-3-ene-8- carboxamid, 6-(3,5-dichlorphenyl)-N-[[2- (ethylamino)pyrimidin-4-yl]methyl]-2,4-dimethyl-7-oxo-6-azab icyclo[3.2.1]oct-3-ene-8-carboxamid, N- [(2-chlorpyridin-4-yl)methyl]-2,4-dimethyl-7-oxo-6-(3,4,5-tr ichlorphenyl)-6-azabicyclo[3.2.1]oct-3- ene-8-carboxamid, 1-(3,5-dichlorphenyl)-3-methyl-5-oxo-N-[[2-(2,2,2-trifluoret hoxy)pyridin-4- yl]methyl]pyrrolidine-3-carboxamid, 1-(3,5-dichlorphenyl)-3-methyl-N-[(2-morpholin-4-ylpyridin-4 - yl)methyl]-5-oxopyrrolidine-3-carboxamid, 1-(4-chlorphenyl)-N-[(2-chlorphenyl)methyl]-5- oxopyrrolidine-3-carboxamid, 1-(4-chlorphenyl)-N-[(2,4-dichlorphenyl)methyl]-5-oxopyrroli dine-3- carboxamid, 1-(4-chlorphenyl)-N-[(4-chlorphenyl)methyl]-5-oxopyrrolidine -3-carboxamid, 1-(4- chlorphenyl)-N-[(4-methoxyphenyl)methyl]-5-oxopyrrolidine-3- carboxamid, N-[(5-chlor-2- methylphenyl)methyl]-1-(4-chlorphenyl)-5-oxopyrrolidine-3-ca rboxamid, N-[(4-fluorphenyl)methyl]-1- (4-methylphenyl)-5-oxopyrrolidine-3-carboxamid, N-[(4-chlorphenyl)methyl]-1-(4-methylphenyl)-5- oxopyrrolidine-3-carboxamid, N-[(4-methoxyphenyl)methyl]-1-(4-methylphenyl)-5-oxopyrrolid ine-3- carboxamid, N-[(5-chlor-2-methylphenyl)methyl]-1-(4-methylphenyl)-5-oxop yrrolidine-3-carboxamid, N-[(2,4-dichlorphenyl)methyl]-1-(4-methylphenyl)-5-oxopyrrol idine-3-carboxamid, N-[(2,3- difluorphenyl)methyl]-1-methyl-5-oxopyrrolidine-3-carboxamid , 1-methyl-N-[(4- methylphenyl)methyl]-5-oxopyrrolidine-3-carboxamid, 1-cyclopentyl-N-[(4-methylphenyl)methyl]-5- oxopyrrolidine-3-carboxamid, N-[(3-chlor-4-fluorphenyl)methyl]-1-cyclopentyl-5-oxopyrroli dine-3- carboxamid, N-[(3-chlor-4-fluorphenyl)methyl]-1-methyl-5-oxopyrrolidine- 3-carboxamid, 1- cyclopentyl-N-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidine-3 -carboxamid, N-[(5-chlor-2- methylphenyl)methyl]-1-(2-methylpropyl)-5-oxopyrrolidine-3-c arboxamid, 1-cyclobutyl-N-[(4- fluorphenyl)methyl]-5-oxopyrrolidine-3-carboxamid, N-benzyl-1-cyclobutyl-5-oxopyrrolidine-3- carboxamid, 1-cyclobutyl-N-[(4-methoxyphenyl)methyl]-5-oxopyrrolidine-3- carboxamid, N-[(4- chlorphenyl)methyl]-1-cyclobutyl-5-oxopyrrolidine-3-carboxam id, N-[(2-chlorphenyl)methyl]-1- cyclobutyl-5-oxopyrrolidine-3-carboxamid, N-[(4-fluorphenyl)methyl]-1-(2-methylpropyl)-5- oxopyrrolidine-3-carboxamid, 1-cyclobutyl-N-[(2,4-dichlorphenyl)methyl]-5-oxopyrrolidine- 3- carboxamid, N-[(5-chlor-2-methylphenyl)methyl]-1-cyclobutyl-5-oxopyrroli dine-3-carboxamid, N-[1- (3-cyanophenyl)-5-oxopyrrolidin-3-yl]-2-(2,5-dichlorphenyl)a cetamid, 2-(2,5-dichlorphenyl)-N-[1-(4- fluorphenyl)-5-oxopyrrolidin-3-yl]acetamid, 2-(2,5-dichlorphenyl)-N-[1-(3,5-difluorphenyl)-5- oxopyrrolidin-3-yl]acetamid, 2-(2,5-dimethylphenyl)-N-(5-oxo-1-chinolin-8-ylpyrrolidin-3- yl)acetamid, N-[1-(4-cyanophenyl)-5-oxopyrrolidin-3-yl]-2-(2,5-dichlorphe nyl)acetamid, 2-(2,5-dichlorphenyl)-N- [1-(4-methylphenyl)-5-oxopyrrolidin-3-yl]acetamid, 2-(2,5-dichlorphenyl)-N-[1-(4-methoxyphenyl)-5- oxopyrrolidin-3-yl]acetamid, 2-(2,5-dichlorphenyl)-N-[1-(4-methoxyphenyl)-5-oxopyrrolidin -3- yl]acetamid, 2-(2-chlorphenyl)-N-[1-(4-chlorphenyl)-5-oxopyrrolidin-3-yl] acetamid, N-[1-(4- chlorphenyl)-5-oxopyrrolidin-3-yl]-2-(2,5-dichlorphenyl)acet amid, 2-(2,5-dichlorphenyl)-N-[1-(3,5- difluorphenyl)-4-methyl-5-oxopyrrolidin-3-yl]acetamid, 2-(2-chlorphenyl)-N-[1-(3,5-difluorphenyl)-4- methyl-5-oxopyrrolidin-3-yl]acetamid, 2-(2,5-dichlorphenyl)-N-(5-oxo-1-phenylpyrrolidin-3- yl)acetamid, 2-(2,5-dichlorphenyl)-N-[1-(2-fluorphenyl)-5-oxopyrrolidin-3 -yl]acetamid, 2-(2,5- dichlorphenyl)-N-(5-oxo-1-chinolin-8-ylpyrrolidin-3-yl)aceta mid, N-[1-(3,5-difluorphenyl)-5- oxopyrrolidin-3-yl]-2-(2-methylphenyl)acetamid, N-[1-(2-fluorphenyl)-5-oxopyrrolidin-3-yl]-2-(2- methylphenyl)acetamid, N-[1-(4-cyanophenyl)-5-oxopyrrolidin-3-yl]-2-(2,5-dimethylph enyl)acetamid, N-[1-(4-cyanophenyl)-5-oxopyrrolidin-3-yl]-2-(2-methylphenyl )acetamid, N-(1-cyclopropyl-5- oxopyrrolidin-3-yl)-2-(2,5-dichlorphenyl)acetamid, 2-(2-chlorphenyl)-N-[1-(4-methylphenyl)-5- oxopyrrolidin-3-yl]acetamid, N-(1-cyclobutyl-5-oxopyrrolidin-3-yl)-2-(2,5-dichlorphenyl)a cetamid, 2- (2-methylphenyl)-N-(5-oxo-1-phenylpyrrolidin-3-yl)acetamid, 2-(2-chlorphenyl)-N-[1-(2- methylpropyl)-5-oxopyrrolidin-3-yl]acetamid, N-[1-(3,5-difluorphenyl)-5-oxopyrrolidin-3-yl]-2-(2,5- dimethylphenyl)acetamid, 2-(2,5-dimethylphenyl)-N-[1-(4-fluorphenyl)-5-oxopyrrolidin- 3-yl]acetamid, 2-(2,5-dimethylphenyl)-N-(5-oxo-1-phenylpyrrolidin-3-yl)acet amid, N-[1-(4-fluorphenyl)-5- oxopyrrolidin-3-yl]-2-(2-methylphenyl)acetamid, 2-(2,5-dimethylphenyl)-N-[1-(2-fluorphenyl)-5- oxopyrrolidin-3-yl]acetamid, 2-(2,5-dichlorphenyl)-N-(1-isopropyl-5-oxopyrrolidin-3-yl)ac etamid, N- [1-(3-cyanophenyl)-5-oxopyrrolidin-3-yl]-2-(2,5-dimethylphen yl)acetamid, 2-(2-chlorphenyl)-N-[1-(4- methoxyphenyl)-5-oxopyrrolidin-3-yl]acetamid, 2-(2,5-dimethylphenyl)-N-(1-isopropyl-5- oxopyrrolidin-3-yl)acetamid, N-(1-isopropyl-5-oxopyrrolidin-3-yl)-2-(2-methylphenyl)aceta mid, 2-(2,5- dichlorphenyl)-N-[1-(2-methylpropyl)-5-oxopyrrolidin-3-yl]ac etamid, 2-(2-chlorphenyl)-N-(1- cyclobutyl-5-oxopyrrolidin-3-yl)acetamid, 2-(2-chlorphenyl)-N-[2-(2-chlorphenyl)acetyl]-N-(1- cyclobutyl-5-oxopyrrolidin-3-yl)acetamid, 2-(4-chlorphenyl)-N-[2-(4-chlorphenyl)acetyl]-N-[1-(2- methylpropyl)-5-oxopyrrolidin-3-yl]acetamid, 1-(4-fluorphenyl)-3-[1-(4-methylphenyl)-5- oxopyrrolidin-3-yl]harnstoff, 1-(4-brom-3-methylphenyl)-3-(1-cyclopentyl-5-oxopyrrolidin-3 - yl)harnstoff, 1-(2-chlorphenyl)-3-[1-(2-chlorphenyl)-5-oxopyrrolidin-3-yl] harnstoff, 1-(4-chlorphenyl)- 3-[1-(4-methylphenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(2-chlorphenyl)-3-(5-oxo-1-phenylpyrrolidin- 3-yl)harnstoff, 1-(4-chlorphenyl)-3-[1-(4-chlorphenyl)-5-oxopyrrolidin-3-yl] harnstoff, 1-(4- chlorphenyl)-3-(5-oxo-1-phenylpyrrolidin-3-yl)harnstoff, 1-(4-acetylphenyl)-3-(5-oxo-1- phenylpyrrolidin-3-yl)harnstoff, 1-[1-(4-chlorphenyl)-5-oxopyrrolidin-3-yl]-3-(4-fluorphenyl) harnstoff, 1-(5-chlor-2-methylphenyl)-3-[1-(4-methoxyphenyl)-5-oxopyrro lidin-3-yl]harnstoff, 1-(5-chlor-2- methylphenyl)-3-[1-(4-chlorphenyl)-5-oxopyrrolidin-3-yl]harn stoff, 1-(4-fluorphenyl)-3-(5-oxo-1- phenylpyrrolidin-3-yl)harnstoff, 1-(5-chlor-2-methylphenyl)-3-[1-(3-chlorphenyl)-5-oxopyrroli din-3- yl]harnstoff, 1-(6-chlorpyridin-3-yl)-3-[1-(4-methylphenyl)-5-oxopyrrolidi n-3-yl]harnstoff, 1-(6- chlorpyridin-3-yl)-3-[1-(4-methoxyphenyl)-5-oxopyrrolidin-3- yl]harnstoff, 1-[1-(2-chlorphenyl)-5- oxopyrrolidin-3-yl]-3-(6-chlorpyridin-3-yl)harnstoff, 1-(4-chlorphenyl)-3-[1-(2-chlorphenyl)-5- oxopyrrolidin-3-yl]harnstoff, 1-(4-chlorphenyl)-3-[1-(3-chlorphenyl)-5-oxopyrrolidin-3-yl] harnstoff, 1- (2-chlorphenyl)-3-[1-(3-chlorphenyl)-5-oxopyrrolidin-3-yl]ha rnstoff, 1-(2-chlorphenyl)-3-[1-(4- chlorphenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(4-acetylphenyl)-3-[1-(4-chlorphenyl)-5-oxopyrrolidin- 3-yl]harnstoff, 1-(5-chlor-2-methylphenyl)-3-[1-(2-chlorphenyl)-5-oxopyrroli din-3-yl]harnstoff, 1-(2,5- dimethylphenyl)-3-(5-oxo-1-phenylpyrrolidin-3-yl)harnstoff, 1-[1-(3-chlorphenyl)-5-oxopyrrolidin-3- yl]-3-(4-fluorphenyl)harnstoff, 1-[1-(2-chlorphenyl)-5-oxopyrrolidin-3-yl]-3-(4-fluorphenyl) harnstoff, 1-(4-acetylphenyl)-3-[1-(4-methylphenyl)-5-oxopyrrolidin-3-y l]harnstoff, 1-[1-(4-chlorphenyl)-5- oxopyrrolidin-3-yl]-3-(6-methylpyridin-2-yl)harnstoff, 1-(6-chlorpyridin-3-yl)-3-(5-oxo-1- phenylpyrrolidin-3-yl)harnstoff, 1-(2-chlorphenyl)-3-[1-(4-methylphenyl)-5-oxopyrrolidin-3- yl]harnstoff, 1-(5-chlor-2-methylphenyl)-3-(4-methyl-5-oxo-1-phenylpyrroli din-3-yl)harnstoff, 1-[1-(4- chlorphenyl)-5-oxopyrrolidin-3-yl]-3-(6-chlorpyridin-3-yl)ha rnstoff, 1-[1-(3-chlorphenyl)-5- oxopyrrolidin-3-yl]-3-(6-chlorpyridin-3-yl)harnstoff, 1-(4-chlorphenyl)-3-(4-methyl-5-oxo-1- phenylpyrrolidin-3-yl)harnstoff, 1-(6-methylpyridin-2-yl)-3-(5-oxo-1-phenylpyrrolidin-3-yl)ha rnstoff, 1- (4-fluorphenyl)-3-[1-(4-methoxyphenyl)-5-oxopyrrolidin-3-yl] harnstoff, 1-(5-chlor-2-methylphenyl)-3- (5-oxo-1-phenylpyrrolidin-3-yl)harnstoff, 1-[1-(4-methylphenyl)-5-oxopyrrolidin-3-yl]-3-(6- methylpyridin-2-yl)harnstoff, 1-(4-chlorphenyl)-3-[1-(4-methoxyphenyl)-5-oxopyrrolidin-3- yl]harnstoff, 1-(5-chlor-2-methylphenyl)-3-[1-(4-methylphenyl)-5-oxopyrrol idin-3-yl]harnstoff, 1-(5- oxo-1-phenylpyrrolidin-3-yl)-3-pyridin-2-ylharnstoff, 1-(2-chlorphenyl)-3-[1-(4-methoxyphenyl)-5- oxopyrrolidin-3-yl]harnstoff, 1-[1-(4-chlorphenyl)-5-oxopyrrolidin-3-yl]-3-(2,5-difluorphe nyl)harnstoff, 1-(2,5-difluorphenyl)-3-[1-(4-methylphenyl)-5-oxopyrrolidin- 3-yl]harnstoff, 1-[1-(4-cyanophenyl)-5- oxopyrrolidin-3-yl]-3-(2-fluorphenyl)harnstoff, 4-[4-[3-(2-chlorphenyl)-2,4,5-trioxoimidazolidin-1-yl]- 2-oxopyrrolidin-1-yl]benzonitril, 1-(2-fluorphenyl)-3-[1-(4-fluorphenyl)-4-methyl-5-oxopyrroli din-3- yl]harnstoff, 1-[1-(3-chlorphenyl)-5-oxopyrrolidin-3-yl]-3-(2,5-dichlorphe nyl)harnstoff, 1-(2,5- dichlorphenyl)-3-[1-(4-methylphenyl)-5-oxopyrrolidin-3-yl]ha rnstoff, 1-(5-chlor-2-methylphenyl)-3-(5- oxo-1-phenylpyrrolidin-3-yl)imidazolidine-2,4,5-trion, 1-(5-chlor-2-methylphenyl)-3-(5-oxo-1-chinolin- 8-ylpyrrolidin-3-yl)harnstoff, 1-(5-chlor-2-methylphenyl)-3-[1-(3-cyanophenyl)-5-oxopyrroli din-3- yl]harnstoff, 1-(5-chlor-2-methylphenyl)-3-[1-(4-cyanophenyl)-5-oxopyrroli din-3-yl]harnstoff, 1-(2- fluorphenyl)-3-(5-oxo-1-chinolin-8-ylpyrrolidin-3-yl)harnsto ff, 1-(2-chlorphenyl)-3-(5-oxo-1-chinolin- 8-ylpyrrolidin-3-yl)harnstoff, 1-(2-chlorphenyl)-3-[1-(3,5-difluorphenyl)-5-oxopyrrolidin-3 -yl]harnstoff, 1-(2,5-difluorphenyl)-3-(5-oxo-1-chinolin-8-ylpyrrolidin-3-y l)harnstoff, 1-(2,5-difluorphenyl)-3-[1-(3,5- difluorphenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(2,5-difluorphenyl)-3-[1-(4-fluorphenyl)-4-methyl-5- oxopyrrolidin-3-yl]harnstoff, 1-(2-fluorphenyl)-3-[1-(2-fluorphenyl)-5-oxopyrrolidin-3- yl]imidazolidine-2,4,5-trion, 1-(2-chlorphenyl)-3-[1-(2-fluorphenyl)-5-oxopyrrolidin-3- yl]imidazolidine-2,4,5-trion, 1-(2-chlorphenyl)-3-(4-methyl-5-oxo-1-phenylpyrrolidin-3- yl)imidazolidine-2,4,5-trion, 1-[1-(4-chlorphenyl)-5-oxopyrrolidin-3-yl]-3-(2- fluorphenyl)imidazolidine-2,4,5-trion, 3-[4-[3-(2-chlorphenyl)-2,4,5-trioxoimidazolidin-1-yl]-2- oxopyrrolidin-1-yl]benzonitril, 1-[1-(3,5-difluorphenyl)-5-oxopyrrolidin-3-yl]-3-(2- fluorphenyl)imidazolidine-2,4,5-trion, 1-(5-chlor-2-methylphenyl)-3-[1-(3,5-difluorphenyl)-5- oxopyrrolidin-3-yl]harnstoff, 1-(5-chlor-2-methylphenyl)-3-[1-(4-fluorphenyl)-4-methyl-5- oxopyrrolidin-3-yl]harnstoff, 1-(2,3-dichlorphenyl)-3-[1-(4-methylphenyl)-5-oxopyrrolidin- 3- yl]harnstoff, 1-(2-fluorphenyl)-3-[1-(4-methylphenyl)-5-oxopyrrolidin-3-yl ]harnstoff, 1-(2,6- difluorphenyl)-3-[1-(4-methylphenyl)-5-oxopyrrolidin-3-yl]ha rnstoff, 1-[1-(3,5-difluorphenyl)-5- oxopyrrolidin-3-yl]-3-(2-methylphenyl)harnstoff, 1-(2-chlorphenyl)-3-[1-(2-fluorphenyl)-5- oxopyrrolidin-3-yl]harnstoff, 1-(2-chlorphenyl)-3-[1-(4-fluorphenyl)-4-methyl-5-oxopyrroli din-3- yl]harnstoff, 1-[1-(3,5-difluorphenyl)-5-oxopyrrolidin-3-yl]-3-(2-fluorphe nyl)harnstoff, 1-(2- chlorphenyl)-3-[1-(3-cyanophenyl)-5-oxopyrrolidin-3-yl]harns toff, 1-(2-fluorphenyl)-3-[1-(2- fluorphenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(2-fluorphenyl)-3-(4-methyl-5-oxo-1-phenylpyrrolidin-3- yl)harnstoff, 1-(2-chlorphenyl)-3-(1-cyclopentyl-5-oxopyrrolidin-3-yl)harn stoff, 1-[1-(3-cyanophenyl)- 5-oxopyrrolidin-3-yl]-3-(2-fluorphenyl)harnstoff, 1-(2-chlorphenyl)-3-[1-(4-cyanophenyl)-5- oxopyrrolidin-3-yl]harnstoff, 1-(2-chlorphenyl)-3-(4-methyl-5-oxo-1-phenylpyrrolidin-3-yl) harnstoff, 1- (2,5-difluorphenyl)-3-(4-methyl-5-oxo-1-phenylpyrrolidin-3-y l)harnstoff, 1-[1-(3-chlorphenyl)-5- oxopyrrolidin-3-yl]-3-(2,6-dichlorphenyl)harnstoff, 1-(5-chlor-2-methylphenyl)-3-[1-(2-methylpropyl)- 5-oxopyrrolidin-3-yl]harnstoff, 1-(1-cyclopentyl-5-oxopyrrolidin-3-yl)-3-(2,5-difluorphenyl) harnstoff, 1-(1-cyclobutyl-5-oxopyrrolidin-3-yl)-3-(2-fluorphenyl)harns toff, 1-(2,5-difluorphenyl)-3-(1-isopropyl- 5-oxopyrrolidin-3-yl)harnstoff, 1-(1-cyclobutyl-5-oxopyrrolidin-3-yl)-3-(2-methylphenyl)harn stoff, 1- (1-cyclopropyl-5-oxopyrrolidin-3-yl)-3-(2,5-difluorphenyl)ha rnstoff, 1-(1-cyclobutyl-5-oxopyrrolidin-3- yl)-3-(2,5-difluorphenyl)harnstoff, 1-(2-fluorphenyl)-3-[1-(2-methylpropyl)-5-oxopyrrolidin-3- yl]harnstoff, 1-(2-methylphenyl)-3-[1-(2-methylpropyl)-5-oxopyrrolidin-3-y l]harnstoff, 1-(2,5- difluorphenyl)-3-[1-(2-methylpropyl)-5-oxopyrrolidin-3-yl]ha rnstoff, 1-(2-chlorphenyl)-3-(1- cyclobutyl-5-oxopyrrolidin-3-yl)harnstoff, 1-(2-chlorphenyl)-3-(1-cyclopropyl-5-oxopyrrolidin-3- yl)harnstoff, 1-(2-chlorphenyl)-3-[1-(2-methylpropyl)-5-oxopyrrolidin-3-yl ]harnstoff, 1-(2- chlorphenyl)-3-(1-isopropyl-5-oxopyrrolidin-3-yl)harnstoff, 1-(1-cyclopropyl-5-oxopyrrolidin-3-yl)-3- (2-fluorphenyl)harnstoff, 1-(2-fluorphenyl)-3-(1-isopropyl-5-oxopyrrolidin-3-yl)harnst off, 1-(1- cyclopentyl-5-oxopyrrolidin-3-yl)-3-(2-fluorphenyl)harnstoff , 1-[1-(3-cyanophenyl)-5-oxopyrrolidin-3- yl]-3-(2,5-difluorphenyl)harnstoff, 1-(2,5-difluorphenyl)-3-[1-(2-fluorphenyl)-5-oxopyrrolidin-3 - yl]harnstoff, 1-[1-(2-fluorphenyl)-5-oxopyrrolidin-3-yl]-3-(2-methylphenyl )harnstoff, 1-[1-(4- chlorphenyl)-5-oxopyrrolidin-3-yl]-3-(2-methylphenyl)harnsto ff, 1-(5-chlor-2-methylphenyl)-3-[1-(4- fluorphenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(5-chlor-2-methylphenyl)-3-[1-(2-fluorphenyl)-5- oxopyrrolidin-3-yl]harnstoff, 1-[1-(4-cyanophenyl)-5-oxopyrrolidin-3-yl]-3-(2,5- difluorphenyl)harnstoff, 1-(2,6-difluorphenyl)-3-[1-(4-fluorphenyl)-5-oxopyrrolidin-3 -yl]harnstoff, 1-(5- chlor-2-methylphenyl)-3-(1-cyclopentyl-5-oxopyrrolidin-3-yl) harnstoff, 1-(4-chlorphenyl)-3-[1-(2- methylpropyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(4-chlorphenyl)-3-(1-cyclobutyl-5-oxopyrrolidin-3- yl)harnstoff, 1-(5-chlor-2-methylphenyl)-3-(1-cyclobutyl-5-oxopyrrolidin-3 -yl)harnstoff, 1-(5-chlor-2- methylphenyl)-3-(1-cyclopropyl-5-oxopyrrolidin-3-yl)harnstof f, 1-(5-chlor-2-methylphenyl)-3-(1- isopropyl-5-oxopyrrolidin-3-yl)harnstoff, 1-[1-(4-chlorphenyl)-5-oxopyrrolidin-3-yl]-3-(2- fluorphenyl)harnstoff, 1-[1-(4-chlorphenyl)-5-oxopyrrolidin-3-yl]-3-(2-fluorphenyl) harnstoff, 1-(2,5- dichlorphenyl)-3-[1-(4-fluorphenyl)-5-oxopyrrolidin-3-yl]har nstoff, 1-(2-chlorpyridin-4-yl)-3-[1-(4- fluorphenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-[1-(4-cyanophenyl)-5-oxopyrrolidin-3-yl]-3-pyridazin-4- ylharnstoff, 1-(4-fluorphenyl)-3-(5-oxo-1-chinolin-8-ylpyrrolidin-3-yl)ha rnstoff, 1-[1-(4-cyanophenyl)- 5-oxopyrrolidin-3-yl]-3-[2-(trifluormethyl)phenyl]harnstoff, 1-(5-oxo-1-chinolin-8-ylpyrrolidin-3-yl)-3- [2-(trifluormethyl)phenyl]harnstoff, 1-(2-cyanophenyl)-3-(5-oxo-1-chinolin-8-ylpyrrolidin-3- yl)harnstoff, 1-[1-(4-fluorphenyl)-5-oxopyrrolidin-3-yl]-3-[2-(trifluormet hyl)phenyl]harnstoff, 1-(2- chlorpyridin-4-yl)-3-(5-oxo-1-chinolin-8-ylpyrrolidin-3-yl)h arnstoff, 1-(5-oxo-1-phenylpyrrolidin-3-yl)- 3-[2-(trifluormethyl)phenyl]harnstoff, 1-(4-fluorphenyl)-3-[1-(4-fluorphenyl)-5-oxopyrrolidin-3- yl]harnstoff, 1-(5-oxo-1-chinolin-8-ylpyrrolidin-3-yl)-3-phenylharnstoff, 1-(2-chlorpyridin-4-yl)-3-[1- (4-cyanophenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-[1-(4-cyanophenyl)-5-oxopyrrolidin-3-yl]-3-(4- fluorphenyl)harnstoff, 1-(2-cyanophenyl)-3-[1-(4-cyanophenyl)-5-oxopyrrolidin-3-yl] harnstoff, 1-(2- cyanophenyl)-3-[1-(4-fluorphenyl)-5-oxopyrrolidin-3-yl]harns toff, 1-(2-chlorpyridin-4-yl)-3-(5-oxo-1- phenylpyrrolidin-3-yl)harnstoff, 1-(2-cyanophenyl)-3-(5-oxo-1-phenylpyrrolidin-3-yl)harnstoff , 1-(1- isopropyl-5-oxopyrrolidin-3-yl)-3-phenylharnstoff.1-(4-fluor phenyl)-3-(1-isopropyl-5-oxopyrrolidin-3- yl)harnstoff., 1-(2-cyanophenyl)-3-(1-isopropyl-5-oxopyrrolidin-3-yl)harnst off, 1-(1-isopropyl-5- oxopyrrolidin-3-yl)-3-[2-(trifluormethyl)phenyl]harnstoff, 1-[1-(4-fluorphenyl)-5-oxopyrrolidin-3-yl]-3- pyridazin-4-ylharnstoff, 1-(5-oxo-1-chinolin-8-ylpyrrolidin-3-yl)-3-pyridazin-4-ylhar nstoff, 1-(5-oxo-1- phenylpyrrolidin-3-yl)-3-pyridazin-4-ylharnstoff, 1-(1-isopropyl-5-oxopyrrolidin-3-yl)-3-pyridazin-4- ylharnstoff, 1-[1-(4-fluorphenyl)-5-oxopyrrolidin-3-yl]-3-phenylharnstoff , 1-(2,5-dichlorphenyl)-3-(5- oxo-1-phenylpyrrolidin-3-yl)thioharnstoff, 1-(2,5-dichlorphenyl)-3-[1-(4-fluorphenyl)-5-oxopyrrolidin- 3-yl]thioharnstoff, 1-(2,5-dichlorphenyl)-3-[1-(3,5-difluorphenyl)-5-oxopyrrolid in-3-yl]thioharnstoff, 1- (2,5-dichlorphenyl)-3-[1-(2-fluorphenyl)-5-oxopyrrolidin-3-y l]thioharnstoff, 1-(2,4-dichlorphenyl)-3-[1- (3,5-difluorphenyl)-5-oxopyrrolidin-3-yl]thioharnstoff, 1-(5-chlor-2-methylphenyl)-3-[1-(3- cyanophenyl)-5-oxopyrrolidin-3-yl]thioharnstoff, 1-(5-chlor-2-methylphenyl)-3-[1-(4-fluorphenyl)-5- oxopyrrolidin-3-yl]thioharnstoff, 1-(2,4-dichlorphenyl)-3-[1-(4-fluorphenyl)-5-oxopyrrolidin-3 - yl]thioharnstoff, 1-(5-chlor-2-methylphenyl)-3-[1-(3,5-difluorphenyl)-5-oxopyr rolidin-3- yl]thioharnstoff, 1-(5-chlor-2-methylphenyl)-3-[1-(2-fluorphenyl)-5-oxopyrroli din-3-yl]thioharnstoff, 1- [1-(4-chlorphenyl)-5-oxopyrrolidin-3-yl]-3-(2,5-dichlorpheny l)thioharnstoff, 1-(5-chlor-2- methylphenyl)-3-(5-oxo-1-phenylpyrrolidin-3-yl)thioharnstoff , 1-(2,4-dichlorphenyl)-3-(5-oxo-1- phenylpyrrolidin-3-yl)thioharnstoff, 1-(2,4-dichlorphenyl)-3-[1-(2-fluorphenyl)-5-oxopyrrolidin-3 - yl]thioharnstoff, 1-(2,5-dichlorphenyl)-3-(1-isopropyl-5-oxopyrrolidin-3-yl)th ioharnstoff, 1-(2,5- dichlorphenyl)-3-[1-(4-methylphenyl)-5-oxopyrrolidin-3-yl]th ioharnstoff, 1-(2,5-dichlorphenyl)-3-[1-(2- methylpropyl)-5-oxopyrrolidin-3-yl]thioharnstoff, 1-(2,5-dichlorphenyl)-3-[1-(2-methylpropyl)-5- oxopyrrolidin-3-yl]thioharnstoff, 1-(2,5-dichlorphenyl)-3-[1-(4-methoxyphenyl)-5-oxopyrrolidin -3- yl]thioharnstoff, 1-(1-cyclopentyl-5-oxopyrrolidin-3-yl)-3-(2,5-dichlorphenyl) thioharnstoff, 1-[1-(4- cyanophenyl)-5-oxopyrrolidin-3-yl]-3-(2,5-dichlorphenyl)thio harnstoff, 1-(5-chlor-2-methylphenyl)-3- (1-cyclopropyl-5-oxopyrrolidin-3-yl)thioharnstoff, 1-[1-(4-cyanophenyl)-5-oxopyrrolidin-3-yl]-3-(2,4- dichlorphenyl)thioharnstoff, 1-(2-chlorphenyl)-3-(1-cyclopentyl-5-oxopyrrolidin-3-yl)thio harnstoff, 1- (2,5-dichlorphenyl)-3-[1-(3,5-difluorphenyl)-4-methyl-5-oxop yrrolidin-3-yl]thioharnstoff, 1-(2- chlorphenyl)-3-[1-(4-methylphenyl)-5-oxopyrrolidin-3-yl]thio harnstoff, 1-(2-chlorphenyl)-3-[1-(4- chlorphenyl)-5-oxopyrrolidin-3-yl]thioharnstoff, 1-(2-chlorphenyl)-3-[1-(2-methylpropyl)-5- oxopyrrolidin-3-yl]thioharnstoff, 1-(5-chlor-2-methylphenyl)-3-(1-isopropyl-5-oxopyrrolidin-3- yl)thioharnstoff, 1-(2-chlorphenyl)-3-[1-(4-methoxyphenyl)-5-oxopyrrolidin-3-y l]thioharnstoff, 1-(1- cyclobutyl-5-oxopyrrolidin-3-yl)-3-(2,5-dichlorphenyl)thioha rnstoff, 1-(2-chlorphenyl)-3-(1-cyclobutyl- 5-oxopyrrolidin-3-yl)thioharnstoff, 1-(5-chlor-2-methylphenyl)-3-[1-(4-cyanophenyl)-5-oxopyrroli din- 3-yl]thioharnstoff, 1-(2,4-dichlorphenyl)-3-(1-isopropyl-5-oxopyrrolidin-3-yl)th ioharnstoff, 1-(5-chlor- 2-methylphenyl)-3-(5-oxo-1-chinolin-8-ylpyrrolidin-3-yl)thio harnstoff Im ganz Speziellen bevorzugter Erfindungsgegenstand ist die Verwendung der folgenden von der allgemeinen Formel (I) beschriebenen Verbindungen: 4-[2-[2-[1-[(4-Methylphenyl)methyl]-5-oxopyrrolidin-2-yl]ace tyl]oxyethoxy]benzoesäure, Methyl-(2S)- 2-[[2-[(2S)-1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2- yl]acetyl]amino]-3-(1H-imidazol-4- yl)propionat, 2-(4-Formylphenoxy)ethyl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, (2R)-2-[[2-[1-[(4-Methylphenyl)methyl]-5-oxopyrrolidin-2-yl] acetyl]amino]-4- methylsulfanylbuttersäure, 2-[(2S)-1-[(2,3-Difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]e ssigsäure, 2-(4- ethylphenoxy)ethyl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, 1-[(2,3- Difluorphenyl)methyl]-5-(2-oxo-2-pyrrolidin-1-ylethyl)pyrrol idin-2-on, 2-(4-methylphenoxy)ethyl 2-[1- [(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, 2-[1-[(2,3-Difluorphenyl)methyl]-5- oxopyrrolidin-2-yl]-N-(chinolin-5-ylmethyl)acetamid, N-Benzyl-2-[1-[(4-methylphenyl)methyl]-5- oxopyrrolidin-2-yl]acetamid, Methyl 3-[[2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2- yl]acetyl]amino]propionat, 2-[1-[(2,3-Difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-met hyl-N- phenylacetamid, Butan-2-yl-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-y l]acetat, (2S)-3-(1H- Indol-3-yl)-2-[[2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidi n-2-yl]acetyl]amino]propionsäure, 2-[1- [(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-[2-(1H-i ndol-3-yl)ethyl]acetamid, N-Butan-2-yl-2- [1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, (2R)-4-Methyl-2-[[2-[(2R)-1-[(4- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]penta ncarbonsäure, 2-[(2R)-1-[(2,3- Difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-methylsulfonyl acetamid, (2S)-2-[[2-[1-[(4- Methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-3-ph enylpropionsäure, (2R)-1-[2-[1-[(4- Methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]pyrrolidin- 2-carbonsäure, 2-[1-[(4- cyanophenyl)methyl]-5-oxopyrrolidin-2-yl]essigsäure, (2S)-2-[[2-[(2S)-1-[(4-Methylphenyl)methyl]-5- oxopyrrolidin-2-yl]acetyl]amino]-3-phenylpropionsäure, Methyl 2-[[2-[1-[(4-methylphenyl)methyl]-5- oxopyrrolidin-2-yl]acetyl]amino]benzoate, N-Cyclopropyl-2-[1-[(4-methylphenyl)methyl]-5- oxopyrrolidin-2-yl]acetamid, N-(Isochinolin-5-ylmethyl)-2-[1-[(4-methylphenyl)methyl]-5- oxopyrrolidin-2-yl]acetamid, N-[2-(2-Bromphenyl)ethyl]-2-[1-[(4-methylphenyl)methyl]-5- oxopyrrolidin-2-yl]acetamid, (2R)-3-(1H-indol-3-yl)-2-[[2-[1-[(4-methylphenyl)methyl]-5- oxopyrrolidin-2-yl]acetyl]amino]propionsäure, N-[2-(1H-indol-3-yl)ethyl]-2-[1-[(4- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, Methyl 2-[[2-[1-[(4-ethylphenyl)methyl]-5- oxopyrrolidin-2-yl]acetyl]-methylamino]acetat, 2-[1-[(4-Methylphenyl)methyl]-5-oxopyrrolidin-2-yl]- N-(quinolin-6-ylmethyl)acetamid, N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-2-[1-[(4- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, N-[(1-ethyl-1H-pyrazol-3-yl)methyl]-2-[1-[(4- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, N-[2-(Diethylamino)ethyl]-2-[1-[(4- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, (2S,3S)-3-Methyl-2-[[2-[(2S)-1-[(3- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]penta ncarbonsäure, 2-[[2-[(2S)-1-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]-methylami no]essigsäure, N-Methylsulfonyl-2-[5- oxo-3-phenyl-1-(pyridin-3-ylmethyl)pyrrolidin-2-yl]acetamid, 2-[1-[(4-Methylphenyl)methyl]-5- oxopyrrolidin-2-yl]propionsäure, methyl (2S)-3-(1H-imidazol-4-yl)-2-[[2-[(2R)-1-[(4- Methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]propi onat, 2-[1-[(2,3-Difluorphenyl)methyl]- 5-oxopyrrolidin-2-yl]-N-[2-(2-methoxyphenyl)ethyl]acetamid, 2-[1-[(4-fluorphenyl)methyl]-5-oxo-3- phenylpyrrolidin-2-yl]essigsäure, 2-[1-[(3-Fluorphenyl)methyl]-5-oxo-3-phenylpyrrolidin-2- yl]essigsäure, Methyl-2-[1-[(3,4-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl ]propionate, 2-(1-Benzyl-5- oxo-3-phenylpyrrolidin-2-yl)essigsäure, N-[2-[3-Chlor-5-(trifluormethyl)pyridin-2-yl]ethyl]-2-[1-[(4 - methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, N-[2-[3-Chlor-5-(Trifluormethyl)pyridin-2- yl]ethyl]-2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2 -yl]acetamid, 1-Cyclopentyl-5-oxo-N- (pyridin-2-ylmethyl)pyrrolidin-3-carboxamid, 1-(4-Chlorphenyl)-N-[(6-chlorpyridin-3-yl)methyl]-5- oxopyrrolidin-3-carboxamid, 1-Cyclobutyl-5-oxo-N-(pyrimidin-2-ylmethyl)pyrrolidin-3-carb oxamid, N- [(5-Chlor-2-methylphenyl)methyl]-1-(4-chlorphenyl)-5-oxopyrr olidin-3-carboxamid, N-[(2,4- Dichlorphenyl)methyl]-1-(4-methylphenyl)-5-oxopyrrolidin-3-c arboxamid, 1-Cyclopentyl-N-[(2,3- difluorphenyl)methyl]-5-oxopyrrolidin-3-carboxamid, N-[1-(4-Cyanophenyl)-5-oxopyrrolidin-3-yl]-2- (2,5-dichlorphenyl)acetamid, 2-(2,5-Dichlorphenyl)-N-[1-(4-methoxyphenyl)-5-oxopyrrolidin -3- yl]acetamid, N-(1-Cyclobutyl-5-oxopyrrolidin-3-yl)-2-(2,5-dichlorphenyl)a cetamid, 2-(2,5- Dichlorphenyl)-N-(1-isopropyl-5-oxopyrrolidin-3-yl)acetamid, 2-(2,5-Dimethylphenyl)-N-(1-isopropyl- 5-oxopyrrolidin-3-yl)acetamid, N-(1-Isopropyl-5-oxopyrrolidin-3-yl)-2-(2-methylphenyl)aceta mid, 2-(2- Chlorphenyl)-N-(1-cyclobutyl-5-oxopyrrolidin-3-yl)acetamid, 1-(5-Chlor-2-methylphenyl)-3-[1-(4- chlorphenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(5-Chlor-2-methylphenyl)-3-[1-(3-chlorphenyl)-5- oxopyrrolidin-3-yl]harnstoff, 1-(6-Chlorpyridin-3-yl)-3-[1-(4-methylphenyl)-5-oxopyrrolidi n-3- yl]harnstoff, 1-(5-Chlor-2-methylphenyl)-3-(4-methyl-5-oxo-1-phenylpyrroli din-3-yl)harnstoff, 1-(4- Chlorphenyl)-3-(4-methyl-5-oxo-1-phenylpyrrolidin-3-yl)harns toff, 1-(5-Chlor-2-methylphenyl)-3-(5- oxo-1-phenylpyrrolidin-3-yl)harnstoff, 1-(5-Chlor-2-methylphenyl)-3-[1-(4-methylphenyl)-5- oxopyrrolidin-3-yl]harnstoff, 1-(2-Chlorphenyl)-3-[1-(4-methoxyphenyl)-5-oxopyrrolidin-3- yl]harnstoff, 1-[1-(4-Cyanophenyl)-5-oxopyrrolidin-3-yl]-3-(2-fluorphenyl) harnstoff, 1-(5-Chlor-2- methylphenyl)-3-[1-(4-cyanophenyl)-5-oxopyrrolidin-3-yl]harn stoff, 1-(2-Chlorphenyl)-3-[1-(3- cyanophenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(2-Fluorphenyl)-3-(4-methyl-5-oxo-1-phenylpyrrolidin- 3-yl)harnstoff, 1-(2-Chlorphenyl)-3-(1-isopropyl-5-oxopyrrolidin-3-yl)harnst off, 1-(5-Chlor-2- methylphenyl)-3-[1-(4-fluorphenyl)-5-oxopyrrolidin-3-yl]harn stoff, 1-(5-Chlor-2-methylphenyl)-3-(1- cyclobutyl-5-oxopyrrolidin-3-yl)harnstoff, 1-(2,5-Dichlorphenyl)-3-[1-(2-fluorphenyl)-5-oxopyrrolidin- 3-yl]thioharnstoff, 1-[1-(4-Cyanophenyl)-5-oxopyrrolidin-3-yl]-3-(2,5-dichlorphe nyl)thioharnstoff, 1- (2-Chlorphenyl)-3-[1-(4-methoxyphenyl)-5-oxopyrrolidin-3-yl] thioharnstoff. Einige der zuvor genannten substituierten Pyrrolidinone der allgemeinen Formel (I) sind ebenfalls noch nicht im Stand der Technik bekannt. Somit gelten als weiterer Teil der Erfindung substituierte N- Pyrrolidinone der allgemeinen Formel (I) oder deren Salze, worin R 1 für (C 1 -C 8 )-Alkyl, (C 2 -C 8 )-Alkenyl, (C 2 -C 8 )-Alkinyl, (C 1 -C 10 )-Haloalkyl, (C 3 -C 10 )-Cycloalkyl, (C 3 -C 10 )-Halocycloalkyl, (C 4 -C 10 )-Cycloalkenyl, Aryl, Aryl-(C 1 -C 8 )-Alkyl, Heteroaryl, Heteroaryl-(C 1 -C 8 )-Alkyl, Heterocyclyl, Heterocyclyl-(C 1 -C 8 )-Alkyl, R 32 O-(C 1 -C 8 )-Alkyl, (C 3 -C 10 )-Cycloalkyl-(C 1 -C 8 )-Alkyl steht, für Wasserstoff steht, R 7 für eine der nachfolgenden Gruppen G-4 bis G-6 steht, wobei ein Pfeil für eine Bindung zum Pyrrolidinonring in der allgemeinen Formel (I) steht, R 3 , R 4 unabhängig voneinander für Wasserstoff, (C 1 -C 8 )-Alkyl, (C 1 -C 10 )-Haloalkyl, (C 3 -C 10 )- Cycloalkyl, (C 3 -C 10 )-Cycloalkyl-(C 1 -C 8 )-Alkyl, OR 32 stehen, R 5 , R 6 unabhängig voneinander für Wasserstoff, (C 1 -C 8 )-Alkyl, (C 2 -C 8 )-Alkenyl, (C 1 -C 10 )-Haloalkyl, (C 3 -C 10 )-Cycloalkyl, Aryl-(C 1 -C 8 )-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C 1 -C 8 )-Alkyl, Heterocyclyl, Heterocyclyl-(C 1 -C 8 )-Alkyl, R 32 O-(C 1 -C 8 )-Alkyl, R 30 R 31 N-(C 1 -C 8 )-Alkyl, NR 30 R 31 , OR 32 , (C 3 -C 10 )-Cycloalkyl-(C 1 -C 8 )-Alkyl stehen, R 8 , R 9 , R 10 unabhängig voneinander für Wasserstoff, (C 1 -C 8 )-Alkyl, (C 2 -C 8 )-Alkenyl, (C 2 -C 8 )-Alkinyl, Aryl-(C 1 -C 8 )-Alkyl, Heteroaryl-(C 1 -C 8 )-Alkyl, C(O=)R 32 , (C 1 -C 8 )-Alkyloxycarbonyl, Aryl- (C 1 -C 8 )-Alkyloxycarbonyl stehen, R 11 , R 12 unabhängig voneinander für Wasserstoff, (C 1 -C 8 )-Alkyl, (C 2 -C 8 )-Alkenyl, (C 2 -C 8 )-Alkinyl, (C 1 -C 10 )-Haloalkyl, (C 3 -C 10 )-Cycloalkyl, Aryl-(C 1 -C 8 )-Alkyl, Aryl, Heteroaryl, Heteroaryl- (C 1 -C 8 )-Alkyl, Heterocyclyl, Heterocyclyl-(C 1 -C 8 )-Alkyl, R 32 O-(C 1 -C 8 )-Alkyl, R 30 R 31 N-(C 1 -C 8 )- Alkyl, (C 3 -C 10 )-Cycloalkyl-(C 1 -C 8 )-Alkyl, C(=O)R 32 , C(=O)OR 32 , C(=O)NR 30 R 31 , R 32 O(O)C- (C 1 -C 8 )-Alkyl, R 30 R 31 N(O)C-(C 1 -C 8 )-Alkyl, OR 32 stehen, R 30 und R 31 unabhängig voneinander für Wasserstoff, (C 1 -C 8 )-Alkyl, (C 2 -C 8 )-Alkenyl, (C 2 -C 8 )-Alkinyl, (C 1 -C 8 )-Cyanoalkyl, (C 1 -C 10 )-Haloalkyl, (C 2 -C 8 )-Haloalkenyl, (C 3 -C 8 )-Haloalkinyl, (C 3 -C 10 )- Cycloalkyl, (C 3 -C 10 )-Halocycloalkyl, (C 4 -C 10 )-Cycloalkenyl, (C 4 -C 10 )-Halocycloalkenyl, (C 1 -C 8 )-Alkoxy-(C 1 -C 8 )-alkyl, (C 1 -C 8 )-Haloalkoxy-(C 1 -C 8 )-alkyl, (C 1 -C 8 )-Alkylthio-(C 1 -C 8 )- alkyl, (C 1 -C 8 )-Haloalkylthio-(C 1 -C 8 )-alkyl, (C 1 -C 8 )-Alkoxy-(C 1 -C 8 )-haloalkyl, Aryl, Aryl- (C 1 -C 8 )-alkyl, Heteroaryl, Heteroaryl-(C 1 -C 8 )-alkyl, (C 3 -C 8 )-Cycloalkyl-(C 1 -C 8 )-alkyl, (C 4 -C 10 )- Cycloalkenyl-(C 1 -C 8 )-alkyl, COR 32 , SO2R 33 , Heterocyclyl, (C 1 -C 8 )-Alkoxycarbonyl, Bis-[(C 1 - C 8 )-alkyl]aminocarbonyl-(C 1 -C 8 )-alkyl, (C 1 -C 8 )-Alkyl-aminocarbonyl-(C 1 -C 8 )-alkyl, Aryl-(C 1 - C 8 )-alkyl-aminocarbonyl-(C 1 -C 8 )-alkyl, Aryl-(C 1 -C 8 )-alkoxycarbonyl, Heteroaryl-(C 1 -C 8 )- alkoxycarbonyl, (C 2 -C 8 )-Alkenyloxycarbonyl, (C 2 -C 8 )-Alkinyloxycarbonyl, (C 1 -C 8 )- Alkoxycarbonyl-(C 1 -C 8 )-alkyl, (C 2 -C 8 )-Alkenyloxycarbonyl-(C 1 -C 8 )-alkyl, (C 2 -C 8 )- Alkinyloxycarbonyl-(C 1 -C 8 )-alkyl, Aryl-(C 1 -C 8 )-alkoxycarbonyl-(C 1 -C 8 )-alkyl, Heteroaryl-(C 1 -C 8 )-alkoxycarbonyl-(C 1 -C 8 )-alkyl, Heterocyclyl-(C 1 -C 8 )- alkoxycarbonyl-(C 1 -C 8 )-alkyl, Heterocyclyl-(C 1 -C 8 )-alkyl stehen, oder R 30 und R 31 mit dem Stickstoffatom, an das sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 3 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, R 32 für Wasserstoff, (C 1 -C 8 )-Alkyl, (C 2 -C 8 )-Alkenyl, (C 2 -C 8 )-Alkinyl, (C 1 -C 8 )-Cyanoalkyl, (C 1 -C 10 )- Haloalkyl, (C 2 -C 8 )-Haloalkenyl, (C 3 -C 8 )-Haloalkinyl, (C 3 -C 10 )-Cycloalkyl, (C 3 -C 10 )- Halocycloalkyl, (C 4 -C 10 )-Cycloalkenyl, (C 4 -C 10 )-Halocycloalkenyl, (C 1 -C 8 )-Alkoxy-(C 1 -C 8 )- alkyl, (C 1 -C 8 )-Haloalkoxy-(C 1 -C 8 )-alkyl, (C 1 -C 8 )-Alkoxy-(C 1 -C 8 )-haloalkyl, (C 1 -C 8 )-Alkoxy- (C 1 -C 8 )-alkoxy-(C 1 -C 8 )-alkyl, (C 1 -C 8 )-Alkoxy-(C 1 -C 8 )-alkoxy-(C 1 -C 8 )-alkoxy-(C 1 -C 8 )-alkyl, (C 1 -C 8 )-Alkoxy-(C 1 -C 8 )-alkoxy-(C 1 -C 8 )-alkoxy-(C 1 -C 8 )-alkoxy-(C 1 -C 8 )-alkyl, Aryl, Aryl- (C 1 -C 8 )-alkyl, Aryl-(C 1 -C 8 )-alkoxy-(C 1 -C 8 )-alkyl, Heteroaryl, Heteroaryl-(C 1 -C 8 )-alkyl, (C 3 -C 8 )- Cycloalkyl-(C 1 -C 8 )-alkyl, (C 4 -C 10 )-Cycloalkenyl-(C 1 -C 8 )-alkyl, Bis-[(C 1 -C 8 )- alkyl]aminocarbonyl-(C 1 -C 8 )-alkyl, (C 1 -C 8 )-Alkyl-aminocarbonyl-(C 1 -C 8 )-alkyl, Aryl-(C 1 -C 8 )- alkyl-aminocarbonyl-(C 1 -C 8 )-alkyl, Bis-[(C 1 -C 8 )-alkyl]amino-(C 2 -C 6 )-alkyl, (C 1 -C 8 )-Alkyl- amino-(C 2 -C 6 )-alkyl, Aryl-(C 1 -C 8 )-alkyl-amino-(C 2 -C 6 )-alkyl, R 33 (O) m S-(C 1 -C 8 )-alkyl, Hydroxycarbonyl-(C 1 -C 8 )-alkyl, Heterocyclyl, Heterocyclyl-(C 1 -C 8 )-alkyl, Tris-[(C 1 -C 8 )- Alkyl]silyl-(C 1 -C 8 )-alkyl, Bis-[(C 1 -C 8 )-Alkyl](aryl)silyl(C 1 -C 8 )-alkyl, [(C 1 -C 8 )-Alkyl]-bis- (aryl)silyl-(C 1 -C 8 )-alkyl, (C 1 -C 8 )-Alkylcarbonyloxy-(C 1 -C 8 )-alkyl, (C 3 -C 8 )- Cycloalkylcarbonyloxy-(C 1 -C 8 )-alkyl, Arylcarbonyloxy-(C 1 -C 8 )-alkyl, Heteroarylcarbonyloxy- (C 1 -C 8 )-alkyl, Heterocyclylcarbonyloxy-(C 1 -C 8 )-alkyl, Aryloxy-(C 1 -C 8 )-alkyl, Heteroaryloxy- (C 1 -C 8 )-alkyl, Heterocyclyloxy-(C 1 -C 8 )-alkyl, (C 1 -C 8 )-Alkoxycarbonyl, (C 1 -C 8 )- Alkoxycarbonyl-(C 1 -C 8 )-alkyl, (C 2 -C 8 )-Alkenyloxycarbonyl-(C 1 -C 8 )-alkyl, (C 2 -C 8 )- Alkinyloxycarbonyl-(C 1 -C 8 )-alkyl, Aryl-(C 1 -C 8 )-alkoxycarbonyl-(C 1 -C 8 )-alkyl, Heteroaryl-(C 1 -C 8 )-alkoxycarbonyl-(C 1 -C 8 )-alkyl, Heterocyclyl-(C 1 -C 8 )- alkoxycarbonyl-(C 1 -C 8 )-alkyl steht, R 33 für Wasserstoff, (C 1 -C 8 )-Alkyl, (C 2 -C 8 )-Alkenyl, (C 2 -C 8 )-Alkinyl, (C 1 -C 8 )-Cyanoalkyl, (C 1 -C 10 )- Haloalkyl, (C 2 -C 8 )-Haloalkenyl, (C 3 -C 8 )-Haloalkinyl, (C 3 -C 10 )-Cycloalkyl, (C 3 -C 10 )- Halocycloalkyl, (C 4 -C 10 )-Cycloalkenyl, (C 4 -C 10 )-Halocycloalkenyl, (C 1 -C 8 )-Alkoxy-(C 1 -C 8 )- alkyl, (C 1 -C 8 )-Alkoxy-(C 1 -C 8 )-haloalkyl, Aryl, Aryl-(C 1 -C 8 )-alkyl, Heteroaryl, Heteroaryl- (C 1 -C 8 )-alkyl, Heterocyclyl-(C 1 -C 8 )-alkyl, (C 3 -C 8 )-Cycloalkyl-(C 1 -C 8 )-alkyl, (C 4 -C 10 )- Cycloalkenyl-(C 1 -C 8 )-alkyl, Bis-[(C 1 -C 8 )-alkyl]amino, (C 1 -C 8 )-Alkyl-amino, Aryl-(C 1 -C 8 )- amino, Aryl-(C 1 -C 6 )-alkyl-amino, Aryl-[(C 1 -C 8 )-alkyl]amino; Heteroaryl-(C 1 -C 8 )-amino, Heteroaryl-(C 1 -C 6 )-alkyl-amino, Heteroaryl-[(C 1 -C 8 )-alkyl]amino; Hetercyclyl-(C 1 -C 8 )-amino, Heterocyclyl-(C 1 -C 6 )-alkyl-amino, Heterocyclyl-[(C 1 -C 8 )-alkyl]amino; (C 3 -C 8 )-Cycloalkyl- amino, (C 3 -C 8 )-Cycloalkyl-[(C 1 -C 8 )-alkyl]amino; N-Azetidinyl, N-Pyrrolidinyl, N-Piperidinyl. N-Morpholinyl steht, R 37 für Phenyl, 2-Fluorphenyl, 4-Fluorphenyl, 4-Brom-3-methylphenyl, 2-Chlorphenyl, 4- Chlorphenyl, 4-Acetylphenyl, 5-Chlor-2-methylphenyl, 2-Chlor-5-methylphenyl, 6- Chlorpyridin-3-yl, 2,5-Dimethylphenyl, 2,5-Difluorphenyl, 2,5-Dichlorphenyl, 6-Methylpyridin- 2-yl, Pyridin-2-yl, 2,3-Dichlorphenyl, 2,6-Difluorphenyl, 2-Methylphenyl, 2,6-Dichlorphenyl, 2- Chlorpyridin-4-yl, Pyridazin-4-yl, 2-(Trifluormethyl)phenyl, 2-Cyanophenyl, 2-Bromphenyl, 2- Iodphenyl, 5-Fluor-2-methylphenyl, 5-Brom-2-methylphenyl, Pyridin-3-yl, 2-Chlorpyridin-3-yl, 2-Fluorpyridin-4-yl, 2-Fluorpyridin-3-yl steht und für 0, 1, 2 steht. Bevorzugt sind Verbindungen der allgemeinen Formel (I), worin R 1 für (C 1 -C 7 )-Alkyl, (C 2 -C 7 )-Alkenyl, (C 2 -C 7 )-Alkinyl, (C 1 -C 10 )-Haloalkyl, (C 3 -C 10 )-Cycloalkyl, (C 3 -C 7 )-Halocycloalkyl, (C 4 -C 7 )-Cycloalkenyl, Aryl, Aryl-(C 1 -C 7 )-Alkyl, Heteroaryl, Heteroaryl-(C 1 -C 7 )-Alkyl, Heterocyclyl, Heterocyclyl-(C 1 -C 7 )-Alkyl, R 32 O-(C 1 -C 7 )-Alkyl, (C 3 -C 10 )-Cycloalkyl-(C 1 -C 7 )-Alkyl steht, R 2 für Wasserstoff steht, R 7 für eine der nachfolgenden Gruppen G-4 bis G-6 steht, wobei ein Pfeil für eine Bindung zum Pyrrolidinonring in der allgemeinen Formel (I) steht, R 3 , R 4 unabhängig voneinander für Wasserstoff, (C 1 -C 7 )-Alkyl, (C 1 -C 7 )-Haloalkyl, (C 3 -C 7 )-Cycloalkyl, (C 3 -C 7 )-Cycloalkyl-(C 1 -C 7 )-Alkyl, OR 32 stehen, R 5 , R 6 unabhängig voneinander für Wasserstoff, (C 1 -C 7 )-Alkyl, (C 2 -C 7 )-Alkenyl, (C 1 -C 7 )-Haloalkyl, (C 3 -C 7 )-Cycloalkyl, Aryl-(C 1 -C 7 )-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C 1 -C 7 )-Alkyl, Heterocyclyl, Heterocyclyl-(C 1 -C 7 )-Alkyl, R 32 O-(C 1 -C 7 )-Alkyl, R 30 R 31 N-(C 1 -C 7 )-Alkyl, NR 30 R 31 , OR 32 , (C 3 -C 7 )-Cycloalkyl-(C 1 -C 7 )-Alkyl stehen, R 8 , R 9 , R 10 unabhängig voneinander für Wasserstoff, (C 1 -C 7 )-Alkyl, (C 2 -C 7 )-Alkenyl, (C 2 -C 7 )-Alkinyl, Aryl-(C 1 -C 7 )-Alkyl, Heteroaryl-(C 1 -C 7 )-Alkyl, C(O=)R 32 , (C 1 -C 7 )-Alkyloxycarbonyl, Aryl- (C 1 -C 7 )-Alkyloxycarbonyl stehen, R 11 , R 12 unabhängig voneinander für Wasserstoff, (C 1 -C 7 )-Alkyl, (C 2 -C 7 )-Alkenyl, (C 2 -C 7 )-Alkinyl, (C 1 -C 7 )-Haloalkyl, (C 3 -C 7 )-Cycloalkyl, Aryl-(C 1 -C 7 )-Alkyl, Aryl, Heteroaryl, Heteroaryl- (C 1 -C 7 )-Alkyl, Heterocyclyl, Heterocyclyl-(C 1 -C 7 )-Alkyl, R 32 O-(C 1 -C 7 )-Alkyl, R 30 R 31 N-(C 1 -C 7 )- Alkyl, (C 3 -C 7 )-Cycloalkyl-(C 1 -C 7 )-Alkyl, C(=O)R 32 , C(=O)OR 32 , C(=O)NR 30 R 31 , R 32 O(O)C- (C 1 -C 7 )-Alkyl, R 30 R 31 N(O)C-(C 1 -C 7 )-Alkyl, OR 32 stehen, R 30 und R 31 unabhängig voneinander für Wasserstoff, (C 1 -C 7 )-Alkyl, (C 2 -C 7 )-Alkenyl, (C 2 -C 7 )-Alkinyl, (C 1 -C 7 )-Cyanoalkyl, (C 1 -C 7 )-Haloalkyl, (C 2 -C 7 )-Haloalkenyl, (C 3 -C 7 )-Haloalkinyl, (C 3 -C 7 )- Cycloalkyl, (C 3 -C 7 )-Halocycloalkyl, (C 4 -C 7 )-Cycloalkenyl, (C 4 -C 7 )-Halocycloalkenyl, (C 1 -C 7 )- Alkoxy-(C 1 -C 7 )-alkyl, (C 1 -C 7 )-Haloalkoxy-(C 1 -C 7 )-alkyl, (C 1 -C 7 )-Alkylthio-(C 1 -C 7 )-alkyl, (C 1 -C 7 )-Haloalkylthio-(C 1 -C 7 )-alkyl, (C 1 -C 7 )-Alkoxy-(C 1 -C 7 )-haloalkyl, Aryl, Aryl-(C 1 -C 7 )- alkyl, Heteroaryl, Heteroaryl-(C 1 -C 7 )-alkyl, (C 3 -C 7 )-Cycloalkyl-(C 1 -C 7 )-alkyl, (C 4 -C 7 )- Cycloalkenyl-(C 1 -C 7 )-alkyl, COR 32 , SO2R 33 , Heterocyclyl, (C 1 -C 7 )-Alkoxycarbonyl, Bis-[(C 1 - C7)-alkyl]aminocarbonyl-(C 1 -C 7 )-alkyl, (C 1 -C 7 )-Alkyl-aminocarbonyl-(C 1 -C 7 )-alkyl, Aryl-(C 1 - C7)-alkyl-aminocarbonyl-(C 1 -C 7 )-alkyl, Aryl-(C 1 -C 7 )-alkoxycarbonyl, Heteroaryl-(C 1 -C 7 )- alkoxycarbonyl, (C 2 -C 7 )-Alkenyloxycarbonyl, (C 2 -C 7 )-Alkinyloxycarbonyl, (C 1 -C 7 )- Alkoxycarbonyl-(C 1 -C 7 )-alkyl, (C 2 -C 7 )-Alkenyloxycarbonyl-(C 1 -C 7 )-alkyl, (C 2 -C 7 )- Alkinyloxycarbonyl-(C 1 -C 7 )-alkyl, Aryl-(C 1 -C 7 )-alkoxycarbonyl-(C 1 -C 7 )-alkyl, Heteroaryl-(C 1 -C 7 )-alkoxycarbonyl-(C 1 -C 7 )-alkyl, Heterocyclyl-(C 1 -C 7 )- alkoxycarbonyl-(C 1 -C 7 )-alkyl, Heterocyclyl-(C 1 -C 7 )-alkyl stehen, oder R 30 und R 31 mit dem Stickstoffatom, an das sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 3 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, R 32 für Wasserstoff, (C 1 -C 7 )-Alkyl, (C 2 -C 7 )-Alkenyl, (C 2 -C 7 )-Alkinyl, (C 1 -C 7 )-Cyanoalkyl, (C 1 -C 7 )- Haloalkyl, (C 2 -C 7 )-Haloalkenyl, (C 3 -C 7 )-Haloalkinyl, (C 3 -C 7 )-Cycloalkyl, (C 3 -C 10 )- Halocycloalkyl, (C 4 -C 7 )-Cycloalkenyl, (C 4 -C 7 )-Halocycloalkenyl, (C 1 -C 7 )-Alkoxy-(C 1 -C 7 )-alkyl, (C 1 -C 7 )-Haloalkoxy-(C 1 -C 7 )-alkyl, (C 1 -C 7 )-Alkoxy-(C 1 -C 7 )-haloalkyl, (C 1 -C 7 )-Alkoxy-(C 1 -C 7 )- alkoxy-(C 1 -C 7 )-alkyl, (C 1 -C 7 )-Alkoxy-(C 1 -C 7 )-alkoxy-(C 1 -C 7 )-alkoxy-(C 1 -C 7 )-alkyl, (C 1 -C 7 )- Alkoxy-(C 1 -C 7 )-alkoxy-(C 1 -C 7 )-alkoxy-(C 1 -C 7 )-alkoxy-(C 1 -C 7 )-alkyl, Aryl, Aryl-(C 1 -C 7 )-alkyl, Aryl-(C 1 -C 7 )-alkoxy-(C 1 -C 7 )-alkyl, Heteroaryl, Heteroaryl-(C 1 -C 7 )-alkyl, (C 3 -C 7 )-Cycloalkyl- (C 1 -C 7 )-alkyl, (C 4 -C 7 )-Cycloalkenyl-(C 1 -C 7 )-alkyl, Bis-[(C 1 -C 7 )-alkyl]aminocarbonyl-(C 1 -C 7 )- alkyl, (C 1 -C 7 )-Alkyl-aminocarbonyl-(C 1 -C 7 )-alkyl, Aryl-(C 1 -C 7 )-alkyl-aminocarbonyl-(C 1 -C 7 )- alkyl, Bis-[(C 1 -C 7 )-alkyl]amino-(C 2 -C 6 )-alkyl, (C 1 -C 7 )-Alkyl-amino-(C 2 -C 6 )-alkyl, Aryl-(C 1 -C 7 )- alkyl-amino-(C 2 -C 6 )-alkyl, R 33 (O) m S-(C 1 -C 7 )-alkyl, Hydroxycarbonyl-(C 1 -C 7 )-alkyl, Heterocyclyl, Heterocyclyl-(C 1 -C 7 )-alkyl, Tris-[(C 1 -C 7 )-Alkyl]silyl-(C 1 -C 7 )-alkyl, Bis-[(C 1 -C 7 )- Alkyl](aryl)silyl(C 1 -C 7 )-alkyl, [(C 1 -C 7 )-Alkyl]-bis-(aryl)silyl-(C 1 -C 7 )-alkyl, (C 1 -C 7 )- Alkylcarbonyloxy-(C 1 -C 7 )-alkyl, (C 3 -C 7 )-Cycloalkylcarbonyloxy-(C 1 -C 7 )-alkyl, Arylcarbonyloxy-(C 1 -C 7 )-alkyl, Heteroarylcarbonyloxy-(C 1 -C 7 )-alkyl, Heterocyclylcarbonyloxy-(C 1 -C 7 )-alkyl, Aryloxy-(C 1 -C 7 )-alkyl, Heteroaryloxy-(C 1 -C 7 )-alkyl, Heterocyclyloxy-(C 1 -C 7 )-alkyl, (C 1 -C 7 )-Alkoxycarbonyl, (C 1 -C 7 )-Alkoxycarbonyl-(C 1 -C 7 )- alkyl, (C 2 -C 7 )-Alkenyloxycarbonyl-(C 1 -C 7 )-alkyl, (C 2 -C 7 )-Alkinyloxycarbonyl-(C 1 -C 7 )- alkyl, Aryl-(C 1 -C 7 )-alkoxycarbonyl-(C 1 -C 7 )-alkyl, Heteroaryl-(C 1 -C 7 )-alkoxycarbonyl- (C 1 -C 7 )-alkyl, Heterocyclyl-(C 1 -C 7 )-alkoxycarbonyl-(C 1 -C 7 )-alkyl steht, R 33 für Wasserstoff, (C 1 -C 7 )-Alkyl, (C 2 -C 7 )-Alkenyl, (C 2 -C 7 )-Alkinyl, (C 1 -C 7 )-Cyanoalkyl, (C 1 -C 7 )- Haloalkyl, (C 2 -C 7 )-Haloalkenyl, (C 3 -C 7 )-Haloalkinyl, (C 3 -C 7 )-Cycloalkyl, (C 3 -C 7 )- Halocycloalkyl, (C 4 -C 7 )-Cycloalkenyl, (C 4 -C 7 )-Halocycloalkenyl, (C 1 -C 7 )-Alkoxy-(C 1 -C 7 )-alkyl, (C 1 -C 7 )-Alkoxy-(C 1 -C 7 )-haloalkyl, Aryl, Aryl-(C 1 -C 7 )-alkyl, Heteroaryl, Heteroaryl-(C 1 -C 7 )- alkyl, Heterocyclyl-(C 1 -C 7 )-alkyl, (C 3 -C 7 )-Cycloalkyl-(C 1 -C 7 )-alkyl, (C 4 -C 10 )-Cycloalkenyl- (C 1 -C 7 )-alkyl, Bis-[(C 1 -C 7 )-alkyl]amino, (C 1 -C 7 )-Alkyl-amino, Aryl-(C 1 -C 7 )-amino, Aryl-(C 1 - C 6 )-alkyl-amino, Aryl-[(C 1 -C 7 )-alkyl]amino; Heteroaryl-(C 1 -C 7 )-amino, Heteroaryl-(C 1 -C 6 )- alkyl-amino, Heteroaryl-[(C 1 -C 7 )-alkyl]amino; Hetercyclyl-(C 1 -C 7 )-amino, Heterocyclyl-(C 1 - C 6 )-alkyl-amino, Heterocyclyl-[(C 1 -C 7 )-alkyl]amino; (C 3 -C 7 )-Cycloalkyl-amino, (C 3 -C 7 )- Cycloalkyl-[(C 1 -C 7 )-alkyl]amino; N-Azetidinyl, N-Pyrrolidinyl, N-Piperidinyl. N-Morpholinyl steht, R 37 für Phenyl, 2-Fluorphenyl, 4-Fluorphenyl, 4-Brom-3-methylphenyl, 2-Chlorphenyl, 4- Chlorphenyl, 4-Acetylphenyl, 5-Chlor-2-methylphenyl, 2-Chlor-5-methylphenyl, 6- Chlorpyridin-3-yl, 2,5-Dimethylphenyl, 2,5-Difluorphenyl, 2,5-Dichlorphenyl, 6-Methylpyridin- 2-yl, Pyridin-2-yl, 2,3-Dichlorphenyl, 2,6-Difluorphenyl, 2-Methylphenyl, 2,6-Dichlorphenyl, 2- Chlorpyridin-4-yl, Pyridazin-4-yl, 2-(Trifluormethyl)phenyl, 2-Cyanophenyl steht und m für 0, 1, 2 steht. Besonders bevorzugt sind Verbindungen der allgemeinen Formel (I), worin R 1 für (C 1 -C 6 )-Alkyl, (C 2 -C 6 )-Alkenyl, (C 2 -C 6 )-Alkinyl, (C 1 -C 10 )-Haloalkyl, (C 3 -C 10 )-Cycloalkyl, (C 3 -C 6 )-Halocycloalkyl, (C 4 -C 6 )-Cycloalkenyl, Aryl, Aryl-(C 1 -C 6 )-Alkyl, Heteroaryl, Heteroaryl-(C 1 -C 6 )-Alkyl, Heterocyclyl, Heterocyclyl-(C 1 -C 6 )-Alkyl, R 32 O-(C 1 -C 6 )-Alkyl, (C 3 -C 10 )-Cycloalkyl-(C 1 -C 6 )-Alkyl steht, R 2 für Wasserstoff steht, R 7 für eine der nachfolgenden Gruppen G-4 bis G-6 steht, wobei ein Pfeil für eine Bindung zum Pyrrolidinonring in der allgemeinen Formel (I) steht, R 3 , R 4 unabhängig voneinander für Wasserstoff, (C 1 -C 6 )-Alkyl, (C 1 -C 6 )-Haloalkyl, (C 3 -C 6 )-Cycloalkyl, (C 3 -C 6 )-Cycloalkyl-(C 1 -C 6 )-Alkyl, OR 32 stehen, R 5 , R 6 unabhängig voneinander für Wasserstoff, (C 1 -C 6 )-Alkyl, (C 2 -C 6 )-Alkenyl, (C 1 -C 6 )-Haloalkyl, (C 3 -C 6 )-Cycloalkyl, Aryl-(C 1 -C 6 )-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C 1 -C 6 )-Alkyl, Heterocyclyl, Heterocyclyl-(C 1 -C 6 )-Alkyl, R 32 O-(C 1 -C 6 )-Alkyl, R 30 R 31 N-(C 1 -C 6 )-Alkyl, NR 30 R 31 , OR 32 , (C 3 -C 6 )-Cycloalkyl-(C 1 -C 6 )-Alkyl stehen, R 8 , R 9 , R 10 unabhängig voneinander für Wasserstoff, (C 1 -C 6 )-Alkyl, (C 2 -C 6 )-Alkenyl, (C 2 -C 6 )-Alkinyl, Aryl-(C 1 -C 6 )-Alkyl, Heteroaryl-(C 1 -C 6 )-Alkyl, C(O=)R 32 , (C 1 -C 6 )-Alkyloxycarbonyl, Aryl- (C 1 -C 6 )-Alkyloxycarbonyl stehen, R 11 , R 12 unabhängig voneinander für Wasserstoff, (C 1 -C 6 )-Alkyl, (C 2 -C 6 )-Alkenyl, (C 2 -C 6 )-Alkinyl, (C 1 -C 6 )-Haloalkyl, (C 3 -C 6 )-Cycloalkyl, Aryl-(C 1 -C 6 )-Alkyl, Aryl, Heteroaryl, Heteroaryl- (C 1 -C 6 )-Alkyl, Heterocyclyl, Heterocyclyl-(C 1 -C 6 )-Alkyl, R 32 O-(C 1 -C 6 )-Alkyl, R 30 R 31 N-(C 1 -C 6 )- Alkyl, (C 3 -C 6 )-Cycloalkyl-(C 1 -C 6 )-Alkyl, C(=O)R 32 , C(=O)OR 32 , C(=O)NR 30 R 31 , R 32 O(O)C- (C 1 -C 6 )-Alkyl, R 30 R 31 N(O)C-(C 1 -C 6 )-Alkyl, OR 32 stehen, R 30 und R 31 gleich oder verschieden sind und unabhängig voneinander für Wasserstoff, (C 1 -C 6 )-Alkyl, (C 2 -C 6 )-Alkenyl, (C 2 -C 6 )-Alkinyl, (C 1 -C 6 )-Cyanoalkyl, (C 1 -C 6 )-Haloalkyl, (C 2 -C 6 )-Haloalkenyl, (C 3 -C 6 )-Haloalkinyl, (C 3 -C 6 )-Cycloalkyl, (C 3 -C 6 )-Halocycloalkyl, (C 4 -C 6 )-Cycloalkenyl, (C 4 -C 6 )-Halocycloalkenyl, (C 1 -C 6 )-Alkoxy-(C 1 -C 6 )-alkyl, (C 1 -C 6 )-Haloalkoxy-(C 1 -C 6 )-alkyl, (C 1 -C 6 )-Alkylthio-(C 1 -C 6 )-alkyl, (C 1 -C 6 )-Haloalkylthio-(C 1 -C 6 )-alkyl, (C 1 -C 6 )-Alkoxy-(C 1 -C 6 )- haloalkyl, Aryl, Aryl-(C 1 -C 6 )-alkyl, Heteroaryl, Heteroaryl-(C 1 -C 6 )-alkyl, (C 3 -C 6 )-Cycloalkyl- (C 1 -C 6 )-alkyl, (C 4 -C 6 )-Cycloalkenyl-(C 1 -C 6 )-alkyl, COR 32 , SO2R 33 , Heterocyclyl, (C 1 -C 6 )- Alkoxycarbonyl, Bis-[(C 1 -C 6 )-alkyl]aminocarbonyl-(C 1 -C 6 )-alkyl, (C 1 -C 6 )-Alkyl- aminocarbonyl-(C 1 -C 6 )-alkyl, Aryl-(C 1 -C 6 )-alkyl-aminocarbonyl-(C 1 -C 6 )-alkyl, Aryl-(C 1 -C 6 )- alkoxycarbonyl, Heteroaryl-(C 1 -C 6 )-alkoxycarbonyl, (C 2 -C 6 )-Alkenyloxycarbonyl, (C 2 -C 6 )- A lkinyloxycarbonyl, (C 1 -C 6 )-Alkoxycarbonyl-(C 1 -C 6 )-alkyl, (C 2 -C 6 )- Alkenyloxycarbonyl-(C 1 -C 6 )-alkyl, (C 2 -C 6 )-Alkinyloxycarbonyl-(C 1 -C 6 )-alkyl, Aryl- (C 1 -C 6 )-alkoxycarbonyl-(C 1 -C 6 )-alkyl, Heteroaryl-(C 1 -C 6 )-alkoxycarbonyl-(C 1 -C 6 )- alkyl, Heterocyclyl-(C 1 -C 6 )-alkoxycarbonyl-(C 1 -C 6 )-alkyl, Heterocyclyl-(C 1 -C 6 )-alkyl stehen, oder R 30 und R 31 mit dem Stickstoffatom, an das sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 3 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, R 32 für Wasserstoff, (C 1 -C 6 )-Alkyl, (C 2 -C 6 )-Alkenyl, (C 2 -C 6 )-Alkinyl, (C 1 -C 6 )-Cyanoalkyl, (C 1 -C 6 )- Haloalkyl, (C 2 -C 6 )-Haloalkenyl, (C 3 -C 6 )-Haloalkinyl, (C 3 -C 6 )-Cycloalkyl, (C 3 -C 10 )- Halocycloalkyl, (C 4 -C 6 )-Cycloalkenyl, (C 4 -C 6 )-Halocycloalkenyl, (C 1 -C 6 )-Alkoxy-(C 1 -C 6 )-alkyl, (C 1 -C 6 )-Haloalkoxy-(C 1 -C 6 )-alkyl, (C 1 -C 6 )-Alkoxy-(C 1 -C 6 )-haloalkyl, (C 1 -C 6 )-Alkoxy-(C 1 -C 6 )- alkoxy-(C 1 -C 6 )-alkyl, (C 1 -C 6 )-Alkoxy-(C 1 -C 6 )-alkoxy-(C 1 -C 6 )-alkoxy-(C 1 -C 6 )-alkyl, (C 1 -C 6 )- Alkoxy-(C 1 -C 6 )-alkoxy-(C 1 -C 6 )-alkoxy-(C 1 -C 6 )-alkoxy-(C 1 -C 6 )-alkyl, Aryl, Aryl-(C 1 -C 6 )-alkyl, Aryl-(C 1 -C 6 )-alkoxy-(C 1 -C 6 )-alkyl, Heteroaryl, Heteroaryl-(C 1 -C 6 )-alkyl, (C 3 -C 6 )-Cycloalkyl- (C 1 -C 6 )-alkyl, (C 4 -C 6 )-Cycloalkenyl-(C 1 -C 6 )-alkyl, Bis-[(C 1 -C 6 )-alkyl]aminocarbonyl-(C 1 -C 6 )- alkyl, (C 1 -C 6 )-Alkyl-aminocarbonyl-(C 1 -C 6 )-alkyl, Aryl-(C 1 -C 6 )-alkyl-aminocarbonyl-(C 1 -C 6 )- alkyl, Bis-[(C 1 -C 6 )-alkyl]amino-(C 2 -C 6 )-alkyl, (C 1 -C 6 )-Alkyl-amino-(C 2 -C 6 )-alkyl, Aryl-(C 1 -C 6 )- alkyl-amino-(C 2 -C 6 )-alkyl, R 33 (O)mS-(C 1 -C 6 )-alkyl, Hydroxycarbonyl-(C 1 -C 6 )-alkyl, Heterocyclyl, Heterocyclyl-(C 1 -C 6 )-alkyl, Tris-[(C 1 -C 6 )-Alkyl]silyl-(C 1 -C 6 )-alkyl, Bis-[(C 1 -C 6 )- Alkyl](aryl)silyl(C 1 -C 6 )-alkyl, [(C 1 -C 6 )-Alkyl]-bis-(aryl)silyl-(C 1 -C 6 )-alkyl, (C 1 -C 6 )- Alkylcarbonyloxy-(C 1 -C 6 )-alkyl, (C 3 -C 6 )-Cycloalkylcarbonyloxy-(C 1 -C 6 )-alkyl, Arylcarbonyloxy-(C 1 -C 6 )-alkyl, Heteroarylcarbonyloxy-(C 1 -C 6 )-alkyl, Heterocyclylcarbonyloxy-(C 1 -C 6 )-alkyl, Aryloxy-(C 1 -C 6 )-alkyl, Heteroaryloxy-(C 1 -C 6 )-alkyl, Heterocyclyloxy-(C 1 -C 6 )-alkyl, (C 1 -C 6 )-Alkoxycarbonyl, (C 1 -C 6 )-Alkoxycarbonyl-(C 1 -C 6 )-alkyl, (C 2 -C 6 )-Alkenyloxycarbonyl-(C 1 -C 6 )-alkyl, (C 2 -C 6 )-Alkinyloxycarbonyl-(C 1 -C 6 )-alkyl, Aryl- (C 1 -C 6 )-alkoxycarbonyl-(C 1 -C 6 )-alkyl, Heteroaryl-(C 1 -C 6 )-alkoxycarbonyl-(C 1 -C 6 )-alkyl, Heterocyclyl-(C 1 -C 6 )-alkoxycarbonyl-(C 1 -C 6 )-alkyl steht, R 33 für Wasserstoff, (C 1 -C 6 )-Alkyl, (C 2 -C 6 )-Alkenyl, (C 2 -C 6 )-Alkinyl, (C 1 -C 6 )-Cyanoalkyl, (C 1 -C 6 )- Haloalkyl, (C 2 -C 6 )-Haloalkenyl, (C 3 -C 6 )-Haloalkinyl, (C 3 -C 6 )-Cycloalkyl, (C 3 -C 6 )- Halocycloalkyl, (C 4 -C 6 )-Cycloalkenyl, (C 4 -C 6 )-Halocycloalkenyl, (C 1 -C 6 )-Alkoxy-(C 1 -C 6 )-alkyl, (C 1 -C 6 )-Alkoxy-(C 1 -C 6 )-haloalkyl, Aryl, Aryl-(C 1 -C 6 )-alkyl, Heteroaryl, Heteroaryl-(C 1 -C 6 )- alkyl, Heterocyclyl-(C 1 -C 6 )-alkyl, (C 3 -C 6 )-Cycloalkyl-(C 1 -C 6 )-alkyl, (C 4 -C 10 )-Cycloalkenyl- (C 1 -C 6 )-alkyl, Bis-[(C 1 -C 6 )-alkyl]amino, (C 1 -C 6 )-Alkyl-amino, Aryl-(C 1 -C 6 )-amino, Aryl-(C 1 - C 6 )-alkyl-amino, Aryl-[(C 1 -C 6 )-alkyl]amino; Heteroaryl-(C 1 -C 6 )-amino, Heteroaryl-(C 1 -C 6 )- alkyl-amino, Heteroaryl-[(C 1 -C 6 )-alkyl]amino; Hetercyclyl-(C 1 -C 6 )-amino, Heterocyclyl-(C 1 - C 6 )-alkyl-amino, Heterocyclyl-[(C 1 -C 6 )-alkyl]amino; (C 3 -C 6 )-Cycloalkyl-amino, (C 3 -C 6 )- Cycloalkyl-[(C 1 -C 6 )-alkyl]amino; N-Azetidinyl, N-Pyrrolidinyl, N-Piperidinyl. N-Morpholinyl steht, R 37 für Phenyl, l2-Fluorphenyl, 4-Fluorphenyl, 4-Brom-3-methylphenyl, 2-Chlorphenyl, 4- Chlorphenyl, 4-Acetylphenyl, 5-Chlor-2-methylphenyl, 2-Chlor-5-methylphenyl, 6- Chlorpyridin-3-yl, 2,5-Dimethylphenyl, 2,5-Difluorphenyl, 2,5-Dichlorphenyl, 6-Methylpyridin- 2-yl, Pyridin-2-yl, 2,3-Dichlorphenyl, 2,6-Difluorphenyl, 2-Methylphenyl, 2,6-Dichlorphenyl, 2- Chlorpyridin-4-yl, Pyridazin-4-yl, 2-(Trifluormethyl)phenyl, 2-Cyanophenyl steht und m für 0, 1, 2 steht. Ganz besonders bevorzugt sind folgende Verbindungen der allgemeinen Formel (I): N-[1-(3-cyanophenyl)-5-oxopyrrolidin-3-yl]-2-(2,5-dichlorphe nyl)acetamid, 2-(2,5-dichlorphenyl)-N- [1-(4-fluorphenyl)-5-oxopyrrolidin-3-yl]acetamid, 2-(2,5-dichlorphenyl)-N-[1-(3,5-difluorphenyl)-5- oxopyrrolidin-3-yl]acetamid, 2-(2,5-dimethylphenyl)-N-(5-oxo-1-chinolin-8-ylpyrrolidin-3- yl)acetamid, N-[1-(4-cyanophenyl)-5-oxopyrrolidin-3-yl]-2-(2,5-dichlorphe nyl)acetamid, 2-(2,5-dichlorphenyl)-N- [1-(4-methylphenyl)-5-oxopyrrolidin-3-yl]acetamid, 2-(2,5-dichlorphenyl)-N-[1-(4-methoxyphenyl)-5- oxopyrrolidin-3-yl]acetamid, 2-(2,5-dichlorphenyl)-N-[1-(4-methoxyphenyl)-5-oxopyrrolidin -3- yl]acetamid, 2-(2-chlorphenyl)-N-[1-(4-chlorphenyl)-5-oxopyrrolidin-3-yl] acetamid, N-[1-(4- chlorphenyl)-5-oxopyrrolidin-3-yl]-2-(2,5-dichlorphenyl)acet amid, 2-(2,5-dichlorphenyl)-N-[1-(3,5- difluorphenyl)-4-methyl-5-oxopyrrolidin-3-yl]acetamid, 2-(2-chlorphenyl)-N-[1-(3,5-difluorphenyl)-4- methyl-5-oxopyrrolidin-3-yl]acetamid, 2-(2,5-dichlorphenyl)-N-(5-oxo-1-phenylpyrrolidin-3- yl)acetamid, 2-(2,5-dichlorphenyl)-N-[1-(2-fluorphenyl)-5-oxopyrrolidin-3 -yl]acetamid, 2-(2,5- dichlorphenyl)-N-(5-oxo-1-chinolin-8-ylpyrrolidin-3-yl)aceta mid, N-[1-(3,5-difluorphenyl)-5- oxopyrrolidin-3-yl]-2-(2-methylphenyl)acetamid, N-[1-(2-fluorphenyl)-5-oxopyrrolidin-3-yl]-2-(2- methylphenyl)acetamid, N-[1-(4-cyanophenyl)-5-oxopyrrolidin-3-yl]-2-(2,5-dimethylph enyl)acetamid, N-[1-(4-cyanophenyl)-5-oxopyrrolidin-3-yl]-2-(2-methylphenyl )acetamid, N-(1-cyclopropyl-5- oxopyrrolidin-3-yl)-2-(2,5-dichlorphenyl)acetamid, 2-(2-chlorphenyl)-N-[1-(4-methylphenyl)-5- oxopyrrolidin-3-yl]acetamid, N-(1-cyclobutyl-5-oxopyrrolidin-3-yl)-2-(2,5-dichlorphenyl)a cetamid, 2- (2-methylphenyl)-N-(5-oxo-1-phenylpyrrolidin-3-yl)acetamid, 2-(2-chlorphenyl)-N-[1-(2- methylpropyl)-5-oxopyrrolidin-3-yl]acetamid, N-[1-(3,5-difluorphenyl)-5-oxopyrrolidin-3-yl]-2-(2,5- dimethylphenyl)acetamid, 2-(2,5-dimethylphenyl)-N-[1-(4-fluorphenyl)-5-oxopyrrolidin- 3-yl]acetamid, 2-(2,5-dimethylphenyl)-N-(5-oxo-1-phenylpyrrolidin-3-yl)acet amid, N-[1-(4-fluorphenyl)-5- oxopyrrolidin-3-yl]-2-(2-methylphenyl)acetamid, 2-(2,5-dimethylphenyl)-N-[1-(2-fluorphenyl)-5- oxopyrrolidin-3-yl]acetamid, 2-(2,5-dichlorphenyl)-N-(1-isopropyl-5-oxopyrrolidin-3-yl)ac etamid, N- [1-(3-cyanophenyl)-5-oxopyrrolidin-3-yl]-2-(2,5-dimethylphen yl)acetamid, 2-(2-chlorphenyl)-N-[1-(4- methoxyphenyl)-5-oxopyrrolidin-3-yl]acetamid, 2-(2,5-dimethylphenyl)-N-(1-isopropyl-5- oxopyrrolidin-3-yl)acetamid, N-(1-isopropyl-5-oxopyrrolidin-3-yl)-2-(2-methylphenyl)aceta mid, 2-(2,5- dichlorphenyl)-N-[1-(2-methylpropyl)-5-oxopyrrolidin-3-yl]ac etamid, 2-(2-chlorphenyl)-N-(1- cyclobutyl-5-oxopyrrolidin-3-yl)acetamid, 2-(2-chlorphenyl)-N-[2-(2-chlorphenyl)acetyl]-N-(1- cyclobutyl-5-oxopyrrolidin-3-yl)acetamid, 2-(4-chlorphenyl)-N-[2-(4-chlorphenyl)acetyl]-N-[1-(2- methylpropyl)-5-oxopyrrolidin-3-yl]acetamid, 1-(4-fluorphenyl)-3-[1-(4-methylphenyl)-5- oxopyrrolidin-3-yl]harnstoff, 1-(4-brom-3-methylphenyl)-3-(1-cyclopentyl-5-oxopyrrolidin-3 - yl)harnstoff, 1-(2-chlorphenyl)-3-[1-(2-chlorphenyl)-5-oxopyrrolidin-3-yl] harnstoff, 1-(4-chlorphenyl)- 3-[1-(4-methylphenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(2-chlorphenyl)-3-(5-oxo-1-phenylpyrrolidin- 3-yl)harnstoff, 1-(4-chlorphenyl)-3-[1-(4-chlorphenyl)-5-oxopyrrolidin-3-yl] harnstoff, 1-(4- chlorphenyl)-3-(5-oxo-1-phenylpyrrolidin-3-yl)harnstoff, 1-(4-acetylphenyl)-3-(5-oxo-1- phenylpyrrolidin-3-yl)harnstoff, 1-[1-(4-chlorphenyl)-5-oxopyrrolidin-3-yl]-3-(4-fluorphenyl) harnstoff, 1-(5-chlor-2-methylphenyl)-3-[1-(4-methoxyphenyl)-5-oxopyrro lidin-3-yl]harnstoff, 1-(5-chlor-2- methylphenyl)-3-[1-(4-chlorphenyl)-5-oxopyrrolidin-3-yl]harn stoff, 1-(4-fluorphenyl)-3-(5-oxo-1- phenylpyrrolidin-3-yl)harnstoff, 1-(5-chlor-2-methylphenyl)-3-[1-(3-chlorphenyl)-5-oxopyrroli din-3- yl]harnstoff, 1-(6-chlorpyridin-3-yl)-3-[1-(4-methylphenyl)-5-oxopyrrolidi n-3-yl]harnstoff, 1-(6- chlorpyridin-3-yl)-3-[1-(4-methoxyphenyl)-5-oxopyrrolidin-3- yl]harnstoff, 1-[1-(2-chlorphenyl)-5- oxopyrrolidin-3-yl]-3-(6-chlorpyridin-3-yl)harnstoff, 1-(4-chlorphenyl)-3-[1-(2-chlorphenyl)-5- oxopyrrolidin-3-yl]harnstoff, 1-(4-chlorphenyl)-3-[1-(3-chlorphenyl)-5-oxopyrrolidin-3-yl] harnstoff, 1- (2-chlorphenyl)-3-[1-(3-chlorphenyl)-5-oxopyrrolidin-3-yl]ha rnstoff, 1-(2-chlorphenyl)-3-[1-(4- chlorphenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(4-acetylphenyl)-3-[1-(4-chlorphenyl)-5-oxopyrrolidin- 3-yl]harnstoff, 1-(5-chlor-2-methylphenyl)-3-[1-(2-chlorphenyl)-5-oxopyrroli din-3-yl]harnstoff, 1-(2,5- dimethylphenyl)-3-(5-oxo-1-phenylpyrrolidin-3-yl)harnstoff, 1-[1-(3-chlorphenyl)-5-oxopyrrolidin-3- yl]-3-(4-fluorphenyl)harnstoff, 1-[1-(2-chlorphenyl)-5-oxopyrrolidin-3-yl]-3-(4-fluorphenyl) harnstoff, 1-(4-acetylphenyl)-3-[1-(4-methylphenyl)-5-oxopyrrolidin-3-y l]harnstoff, 1-[1-(4-chlorphenyl)-5- oxopyrrolidin-3-yl]-3-(6-methylpyridin-2-yl)harnstoff, 1-(6-chlorpyridin-3-yl)-3-(5-oxo-1- phenylpyrrolidin-3-yl)harnstoff, 1-(2-chlorphenyl)-3-[1-(4-methylphenyl)-5-oxopyrrolidin-3- yl]harnstoff, 1-(5-chlor-2-methylphenyl)-3-(4-methyl-5-oxo-1-phenylpyrroli din-3-yl)harnstoff, 1-[1-(4- chlorphenyl)-5-oxopyrrolidin-3-yl]-3-(6-chlorpyridin-3-yl)ha rnstoff, 1-[1-(3-chlorphenyl)-5- oxopyrrolidin-3-yl]-3-(6-chlorpyridin-3-yl)harnstoff, 1-(4-chlorphenyl)-3-(4-methyl-5-oxo-1- phenylpyrrolidin-3-yl)harnstoff, 1-(6-methylpyridin-2-yl)-3-(5-oxo-1-phenylpyrrolidin-3-yl)ha rnstoff, 1- (4-fluorphenyl)-3-[1-(4-methoxyphenyl)-5-oxopyrrolidin-3-yl] harnstoff, 1-(5-chlor-2-methylphenyl)-3- (5-oxo-1-phenylpyrrolidin-3-yl)harnstoff, 1-[1-(4-methylphenyl)-5-oxopyrrolidin-3-yl]-3-(6- methylpyridin-2-yl)harnstoff, 1-(4-chlorphenyl)-3-[1-(4-methoxyphenyl)-5-oxopyrrolidin-3- yl]harnstoff, 1-(5-chlor-2-methylphenyl)-3-[1-(4-methylphenyl)-5-oxopyrrol idin-3-yl]harnstoff, 1-(5- oxo-1-phenylpyrrolidin-3-yl)-3-pyridin-2-ylharnstoff, 1-(2-chlorphenyl)-3-[1-(4-methoxyphenyl)-5- oxopyrrolidin-3-yl]harnstoff, 1-[1-(4-chlorphenyl)-5-oxopyrrolidin-3-yl]-3-(2,5-difluorphe nyl)harnstoff, 1-(2,5-difluorphenyl)-3-[1-(4-methylphenyl)-5-oxopyrrolidin- 3-yl]harnstoff, 1-[1-(4-cyanophenyl)-5- oxopyrrolidin-3-yl]-3-(2-fluorphenyl)harnstoff, 4-[4-[3-(2-chlorphenyl)-2,4,5-trioxoimidazolidin-1-yl]- 2-oxopyrrolidin-1-yl]benzonitril, 1-(2-fluorphenyl)-3-[1-(4-fluorphenyl)-4-methyl-5-oxopyrroli din-3- yl]harnstoff, 1-[1-(3-chlorphenyl)-5-oxopyrrolidin-3-yl]-3-(2,5-dichlorphe nyl)harnstoff, 1-(2,5- dichlorphenyl)-3-[1-(4-methylphenyl)-5-oxopyrrolidin-3-yl]ha rnstoff, 1-(5-chlor-2-methylphenyl)-3-(5- oxo-1-phenylpyrrolidin-3-yl)imidazolidine-2,4,5-trion, 1-(5-chlor-2-methylphenyl)-3-(5-oxo-1-chinolin- 8-ylpyrrolidin-3-yl)harnstoff, 1-(5-chlor-2-methylphenyl)-3-[1-(3-cyanophenyl)-5-oxopyrroli din-3- yl]harnstoff, 1-(5-chlor-2-methylphenyl)-3-[1-(4-cyanophenyl)-5-oxopyrroli din-3-yl]harnstoff, 1-(2- fluorphenyl)-3-(5-oxo-1-chinolin-8-ylpyrrolidin-3-yl)harnsto ff, 1-(2-chlorphenyl)-3-(5-oxo-1-chinolin- 8-ylpyrrolidin-3-yl)harnstoff, 1-(2-chlorphenyl)-3-[1-(3,5-difluorphenyl)-5-oxopyrrolidin-3 -yl]harnstoff, 1-(2,5-difluorphenyl)-3-(5-oxo-1-chinolin-8-ylpyrrolidin-3-y l)harnstoff, 1-(2,5-difluorphenyl)-3-[1-(3,5- difluorphenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(2,5-difluorphenyl)-3-[1-(4-fluorphenyl)-4-methyl-5- oxopyrrolidin-3-yl]harnstoff, 1-(2-fluorphenyl)-3-[1-(2-fluorphenyl)-5-oxopyrrolidin-3- yl]imidazolidine-2,4,5-trion, 1-(2-chlorphenyl)-3-[1-(2-fluorphenyl)-5-oxopyrrolidin-3- yl]imidazolidine-2,4,5-trion, 1-(2-chlorphenyl)-3-(4-methyl-5-oxo-1-phenylpyrrolidin-3- yl)imidazolidine-2,4,5-trion, 1-[1-(4-chlorphenyl)-5-oxopyrrolidin-3-yl]-3-(2- fluorphenyl)imidazolidine-2,4,5-trion, 3-[4-[3-(2-chlorphenyl)-2,4,5-trioxoimidazolidin-1-yl]-2- oxopyrrolidin-1-yl]benzonitril, 1-[1-(3,5-difluorphenyl)-5-oxopyrrolidin-3-yl]-3-(2- fluorphenyl)imidazolidine-2,4,5-trion, 1-(5-chlor-2-methylphenyl)-3-[1-(3,5-difluorphenyl)-5- oxopyrrolidin-3-yl]harnstoff, 1-(5-chlor-2-methylphenyl)-3-[1-(4-fluorphenyl)-4-methyl-5- oxopyrrolidin-3-yl]harnstoff, 1-(2,3-dichlorphenyl)-3-[1-(4-methylphenyl)-5-oxopyrrolidin- 3- yl]harnstoff, 1-(2-fluorphenyl)-3-[1-(4-methylphenyl)-5-oxopyrrolidin-3-yl ]harnstoff, 1-(2,6- difluorphenyl)-3-[1-(4-methylphenyl)-5-oxopyrrolidin-3-yl]ha rnstoff, 1-[1-(3,5-difluorphenyl)-5- oxopyrrolidin-3-yl]-3-(2-methylphenyl)harnstoff, 1-(2-chlorphenyl)-3-[1-(2-fluorphenyl)-5- oxopyrrolidin-3-yl]harnstoff, 1-(2-chlorphenyl)-3-[1-(4-fluorphenyl)-4-methyl-5-oxopyrroli din-3- yl]harnstoff, 1-[1-(3,5-difluorphenyl)-5-oxopyrrolidin-3-yl]-3-(2-fluorphe nyl)harnstoff, 1-(2- chlorphenyl)-3-[1-(3-cyanophenyl)-5-oxopyrrolidin-3-yl]harns toff, 1-(2-fluorphenyl)-3-[1-(2- fluorphenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(2-fluorphenyl)-3-(4-methyl-5-oxo-1-phenylpyrrolidin-3- yl)harnstoff, 1-(2-chlorphenyl)-3-(1-cyclopentyl-5-oxopyrrolidin-3-yl)harn stoff, 1-[1-(3-cyanophenyl)- 5-oxopyrrolidin-3-yl]-3-(2-fluorphenyl)harnstoff, 1-(2-chlorphenyl)-3-[1-(4-cyanophenyl)-5- oxopyrrolidin-3-yl]harnstoff, 1-(2-chlorphenyl)-3-(4-methyl-5-oxo-1-phenylpyrrolidin-3-yl) harnstoff, 1- (2,5-difluorphenyl)-3-(4-methyl-5-oxo-1-phenylpyrrolidin-3-y l)harnstoff, 1-[1-(3-chlorphenyl)-5- oxopyrrolidin-3-yl]-3-(2,6-dichlorphenyl)harnstoff, 1-(5-chlor-2-methylphenyl)-3-[1-(2-methylpropyl)- 5-oxopyrrolidin-3-yl]harnstoff, 1-(1-cyclopentyl-5-oxopyrrolidin-3-yl)-3-(2,5-difluorphenyl) harnstoff, 1-(1-cyclobutyl-5-oxopyrrolidin-3-yl)-3-(2-fluorphenyl)harns toff, 1-(2,5-difluorphenyl)-3-(1-isopropyl- 5-oxopyrrolidin-3-yl)harnstoff, 1-(1-cyclobutyl-5-oxopyrrolidin-3-yl)-3-(2-methylphenyl)harn stoff, 1- (1-cyclopropyl-5-oxopyrrolidin-3-yl)-3-(2,5-difluorphenyl)ha rnstoff, 1-(1-cyclobutyl-5-oxopyrrolidin-3- yl)-3-(2,5-difluorphenyl)harnstoff, 1-(2-fluorphenyl)-3-[1-(2-methylpropyl)-5-oxopyrrolidin-3- yl]harnstoff, 1-(2-methylphenyl)-3-[1-(2-methylpropyl)-5-oxopyrrolidin-3-y l]harnstoff, 1-(2,5- difluorphenyl)-3-[1-(2-methylpropyl)-5-oxopyrrolidin-3-yl]ha rnstoff, 1-(2-chlorphenyl)-3-(1- cyclobutyl-5-oxopyrrolidin-3-yl)harnstoff, 1-(2-chlorphenyl)-3-(1-cyclopropyl-5-oxopyrrolidin-3- yl)harnstoff, 1-(2-chlorphenyl)-3-[1-(2-methylpropyl)-5-oxopyrrolidin-3-yl ]harnstoff, 1-(2- chlorphenyl)-3-(1-isopropyl-5-oxopyrrolidin-3-yl)harnstoff, 1-(1-cyclopropyl-5-oxopyrrolidin-3-yl)-3- (2-fluorphenyl)harnstoff, 1-(2-fluorphenyl)-3-(1-isopropyl-5-oxopyrrolidin-3-yl)harnst off, 1-(1- cyclopentyl-5-oxopyrrolidin-3-yl)-3-(2-fluorphenyl)harnstoff , 1-[1-(3-cyanophenyl)-5-oxopyrrolidin-3- yl]-3-(2,5-difluorphenyl)harnstoff, 1-(2,5-difluorphenyl)-3-[1-(2-fluorphenyl)-5-oxopyrrolidin-3 - yl]harnstoff, 1-[1-(2-fluorphenyl)-5-oxopyrrolidin-3-yl]-3-(2-methylphenyl )harnstoff, 1-[1-(4- chlorphenyl)-5-oxopyrrolidin-3-yl]-3-(2-methylphenyl)harnsto ff, 1-(5-chlor-2-methylphenyl)-3-[1-(4- fluorphenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(5-chlor-2-methylphenyl)-3-[1-(2-fluorphenyl)-5- oxopyrrolidin-3-yl]harnstoff, 1-[1-(4-cyanophenyl)-5-oxopyrrolidin-3-yl]-3-(2,5- difluorphenyl)harnstoff, 1-(2,6-difluorphenyl)-3-[1-(4-fluorphenyl)-5-oxopyrrolidin-3 -yl]harnstoff, 1-(5- chlor-2-methylphenyl)-3-(1-cyclopentyl-5-oxopyrrolidin-3-yl) harnstoff, 1-(4-chlorphenyl)-3-[1-(2- methylpropyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(4-chlorphenyl)-3-(1-cyclobutyl-5-oxopyrrolidin-3- yl)harnstoff, 1-(5-chlor-2-methylphenyl)-3-(1-cyclobutyl-5-oxopyrrolidin-3 -yl)harnstoff, 1-(5-chlor-2- methylphenyl)-3-(1-cyclopropyl-5-oxopyrrolidin-3-yl)harnstof f, 1-(5-chlor-2-methylphenyl)-3-(1- isopropyl-5-oxopyrrolidin-3-yl)harnstoff, 1-[1-(4-chlorphenyl)-5-oxopyrrolidin-3-yl]-3-(2- fluorphenyl)harnstoff, 1-[1-(4-chlorphenyl)-5-oxopyrrolidin-3-yl]-3-(2-fluorphenyl) harnstoff, 1-(2,5- dichlorphenyl)-3-[1-(4-fluorphenyl)-5-oxopyrrolidin-3-yl]har nstoff, 1-(2-chlorpyridin-4-yl)-3-[1-(4- fluorphenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-[1-(4-cyanophenyl)-5-oxopyrrolidin-3-yl]-3-pyridazin-4- ylharnstoff, 1-(4-fluorphenyl)-3-(5-oxo-1-chinolin-8-ylpyrrolidin-3-yl)ha rnstoff, 1-[1-(4-cyanophenyl)- 5-oxopyrrolidin-3-yl]-3-[2-(trifluormethyl)phenyl]harnstoff, 1-(5-oxo-1-chinolin-8-ylpyrrolidin-3-yl)-3- [2-(trifluormethyl)phenyl]harnstoff, 1-(2-cyanophenyl)-3-(5-oxo-1-chinolin-8-ylpyrrolidin-3- yl)harnstoff, 1-[1-(4-fluorphenyl)-5-oxopyrrolidin-3-yl]-3-[2-(trifluormet hyl)phenyl]harnstoff, 1-(2- chlorpyridin-4-yl)-3-(5-oxo-1-chinolin-8-ylpyrrolidin-3-yl)h arnstoff, 1-(5-oxo-1-phenylpyrrolidin-3-yl)- 3-[2-(trifluormethyl)phenyl]harnstoff, 1-(4-fluorphenyl)-3-[1-(4-fluorphenyl)-5-oxopyrrolidin-3- yl]harnstoff, 1-(5-oxo-1-chinolin-8-ylpyrrolidin-3-yl)-3-phenylharnstoff, 1-(2-chlorpyridin-4-yl)-3-[1- (4-cyanophenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-[1-(4-cyanophenyl)-5-oxopyrrolidin-3-yl]-3-(4- fluorphenyl)harnstoff, 1-(2-cyanophenyl)-3-[1-(4-cyanophenyl)-5-oxopyrrolidin-3-yl] harnstoff, 1-(2- cyanophenyl)-3-[1-(4-fluorphenyl)-5-oxopyrrolidin-3-yl]harns toff, 1-(2-chlorpyridin-4-yl)-3-(5-oxo-1- phenylpyrrolidin-3-yl)harnstoff, 1-(2-cyanophenyl)-3-(5-oxo-1-phenylpyrrolidin-3-yl)harnstoff , 1-(1- isopropyl-5-oxopyrrolidin-3-yl)-3-phenylharnstoff.1-(4-fluor phenyl)-3-(1-isopropyl-5-oxopyrrolidin-3- yl)harnstoff., 1-(2-cyanophenyl)-3-(1-isopropyl-5-oxopyrrolidin-3-yl)harnst off, 1-(1-isopropyl-5- oxopyrrolidin-3-yl)-3-[2-(trifluormethyl)phenyl]harnstoff, 1-[1-(4-fluorphenyl)-5-oxopyrrolidin-3-yl]-3- pyridazin-4-ylharnstoff, 1-(5-oxo-1-chinolin-8-ylpyrrolidin-3-yl)-3-pyridazin-4-ylhar nstoff, 1-(5-oxo-1- phenylpyrrolidin-3-yl)-3-pyridazin-4-ylharnstoff, 1-(1-isopropyl-5-oxopyrrolidin-3-yl)-3-pyridazin-4- ylharnstoff, 1-[1-(4-fluorphenyl)-5-oxopyrrolidin-3-yl]-3-phenylharnstoff , 1-(2,5-dichlorphenyl)-3-(5- oxo-1-phenylpyrrolidin-3-yl)thioharnstoff, 1-(2,5-dichlorphenyl)-3-[1-(4-fluorphenyl)-5-oxopyrrolidin- 3-yl]thioharnstoff, 1-(2,5-dichlorphenyl)-3-[1-(3,5-difluorphenyl)-5-oxopyrrolid in-3-yl]thioharnstoff, 1- (2,5-dichlorphenyl)-3-[1-(2-fluorphenyl)-5-oxopyrrolidin-3-y l]thioharnstoff, 1-(2,4-dichlorphenyl)-3-[1- (3,5-difluorphenyl)-5-oxopyrrolidin-3-yl]thioharnstoff, 1-(5-chlor-2-methylphenyl)-3-[1-(3- cyanophenyl)-5-oxopyrrolidin-3-yl]thioharnstoff, 1-(5-chlor-2-methylphenyl)-3-[1-(4-fluorphenyl)-5- oxopyrrolidin-3-yl]thioharnstoff, 1-(2,4-dichlorphenyl)-3-[1-(4-fluorphenyl)-5-oxopyrrolidin-3 - yl]thioharnstoff, 1-(5-chlor-2-methylphenyl)-3-[1-(3,5-difluorphenyl)-5-oxopyr rolidin-3- yl]thioharnstoff, 1-(5-chlor-2-methylphenyl)-3-[1-(2-fluorphenyl)-5-oxopyrroli din-3-yl]thioharnstoff, 1- [1-(4-chlorphenyl)-5-oxopyrrolidin-3-yl]-3-(2,5-dichlorpheny l)thioharnstoff, 1-(5-chlor-2- methylphenyl)-3-(5-oxo-1-phenylpyrrolidin-3-yl)thioharnstoff , 1-(2,4-dichlorphenyl)-3-(5-oxo-1- phenylpyrrolidin-3-yl)thioharnstoff, 1-(2,4-dichlorphenyl)-3-[1-(2-fluorphenyl)-5-oxopyrrolidin-3 - yl]thioharnstoff, 1-(2,5-dichlorphenyl)-3-(1-isopropyl-5-oxopyrrolidin-3-yl)th ioharnstoff, 1-(2,5- dichlorphenyl)-3-[1-(4-methylphenyl)-5-oxopyrrolidin-3-yl]th ioharnstoff, 1-(2,5-dichlorphenyl)-3-[1-(2- methylpropyl)-5-oxopyrrolidin-3-yl]thioharnstoff, 1-(2,5-dichlorphenyl)-3-[1-(2-methylpropyl)-5- oxopyrrolidin-3-yl]thioharnstoff, 1-(2,5-dichlorphenyl)-3-[1-(4-methoxyphenyl)-5-oxopyrrolidin -3- yl]thioharnstoff, 1-(1-cyclopentyl-5-oxopyrrolidin-3-yl)-3-(2,5-dichlorphenyl) thioharnstoff, 1-[1-(4- cyanophenyl)-5-oxopyrrolidin-3-yl]-3-(2,5-dichlorphenyl)thio harnstoff, 1-(5-chlor-2-methylphenyl)-3- (1-cyclopropyl-5-oxopyrrolidin-3-yl)thioharnstoff, 1-[1-(4-cyanophenyl)-5-oxopyrrolidin-3-yl]-3-(2,4- dichlorphenyl)thioharnstoff, 1-(2-chlorphenyl)-3-(1-cyclopentyl-5-oxopyrrolidin-3-yl)thio harnstoff, 1- (2,5-dichlorphenyl)-3-[1-(3,5-difluorphenyl)-4-methyl-5-oxop yrrolidin-3-yl]thioharnstoff, 1-(2- chlorphenyl)-3-[1-(4-methylphenyl)-5-oxopyrrolidin-3-yl]thio harnstoff, 1-(2-chlorphenyl)-3-[1-(4- chlorphenyl)-5-oxopyrrolidin-3-yl]thioharnstoff, 1-(2-chlorphenyl)-3-[1-(2-methylpropyl)-5- oxopyrrolidin-3-yl]thioharnstoff, 1-(5-chlor-2-methylphenyl)-3-(1-isopropyl-5-oxopyrrolidin-3- yl)thioharnstoff, 1-(2-chlorphenyl)-3-[1-(4-methoxyphenyl)-5-oxopyrrolidin-3-y l]thioharnstoff, 1-(1- cyclobutyl-5-oxopyrrolidin-3-yl)-3-(2,5-dichlorphenyl)thioha rnstoff, 1-(2-chlorphenyl)-3-(1-cyclobutyl- 5-oxopyrrolidin-3-yl)thioharnstoff, 1-(5-chlor-2-methylphenyl)-3-[1-(4-cyanophenyl)-5-oxopyrroli din- 3-yl]thioharnstoff, 1-(2,4-dichlorphenyl)-3-(1-isopropyl-5-oxopyrrolidin-3-yl)th ioharnstoff, 1-(5-chlor- 2-methylphenyl)-3-(5-oxo-1-chinolin-8-ylpyrrolidin-3-yl)thio harnstoff. Im Speziellen bevorzugt sind folgende Verbindungen der allgemeinen Formel (I): N-[1-(4-Cyanophenyl)-5-oxopyrrolidin-3-yl]-2-(2,5-dichlorphe nyl)acetamid, 2-(2,5-Dichlorphenyl)-N- [1-(4-methoxyphenyl)-5-oxopyrrolidin-3-yl]acetamid, N-(1-Cyclobutyl-5-oxopyrrolidin-3-yl)-2-(2,5- dichlorphenyl)acetamid, 2-(2,5-Dichlorphenyl)-N-(1-isopropyl-5-oxopyrrolidin-3-yl)ac etamid, 2-(2,5- Dimethylphenyl)-N-(1-isopropyl-5-oxopyrrolidin-3-yl)acetamid , N-(1-Isopropyl-5-oxopyrrolidin-3-yl)- 2-(2-methylphenyl)acetamid, 2-(2-Chlorphenyl)-N-(1-cyclobutyl-5-oxopyrrolidin-3-yl)aceta mid, 1-(5- Chlor-2-methylphenyl)-3-[1-(4-chlorphenyl)-5-oxopyrrolidin-3 -yl]harnstoff, 1-(5-Chlor-2- methylphenyl)-3-[1-(3-chlorphenyl)-5-oxopyrrolidin-3-yl]harn stoff, 1-(6-Chlorpyridin-3-yl)-3-[1-(4- methylphenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-(5-Chlor-2-methylphenyl)-3-(4-methyl-5-oxo-1- phenylpyrrolidin-3-yl)harnstoff, 1-(4-Chlorphenyl)-3-(4-methyl-5-oxo-1-phenylpyrrolidin-3- yl)harnstoff, 1-(5-Chlor-2-methylphenyl)-3-(5-oxo-1-phenylpyrrolidin-3-yl) harnstoff, 1-(5-Chlor-2- methylphenyl)-3-[1-(4-methylphenyl)-5-oxopyrrolidin-3-yl]har nstoff, 1-(2-Chlorphenyl)-3-[1-(4- methoxyphenyl)-5-oxopyrrolidin-3-yl]harnstoff, 1-[1-(4-Cyanophenyl)-5-oxopyrrolidin-3-yl]-3-(2- fluorphenyl)harnstoff, 1-(5-Chlor-2-methylphenyl)-3-[1-(4-cyanophenyl)-5-oxopyrroli din-3- yl]harnstoff, 1-(2-Chlorphenyl)-3-[1-(3-cyanophenyl)-5-oxopyrrolidin-3-yl] harnstoff, 1-(2- Fluorphenyl)-3-(4-methyl-5-oxo-1-phenylpyrrolidin-3-yl)harns toff, 1-(2-Chlorphenyl)-3-(1-isopropyl-5- oxopyrrolidin-3-yl)harnstoff, 1-(5-Chlor-2-methylphenyl)-3-[1-(4-fluorphenyl)-5-oxopyrroli din-3- yl]harnstoff, 1-(5-Chlor-2-methylphenyl)-3-(1-cyclobutyl-5-oxopyrrolidin-3 -yl)harnstoff, 1-(2,5- Dichlorphenyl)-3-[1-(2-fluorphenyl)-5-oxopyrrolidin-3-yl]thi oharnstoff, 1-[1-(4-Cyanophenyl)-5- oxopyrrolidin-3-yl]-3-(2,5-dichlorphenyl)thioharnstoff, 1-(2-Chlorphenyl)-3-[1-(4-methoxyphenyl)-5- oxopyrrolidin-3-yl]thioharnstoff. Außerdem sind einige weitere der zuvor genannten substituierten Pyrrolidinone der allgemeinen Formel (I) noch nicht im Stand der Technik bekannt. Somit gelten als weiterer Teil der Erfindung substituierte N-Pyrrolidinone der allgemeinen Formel (I) oder deren Salze, worin R 1 für (3-Methylphenyl)methyl, (4-Methylphenyl)methyl, (2-Methylphenyl)methyl, (3- Trifluormethylphenyl)methyl, (4-Trifluorethylphenyl)methyl, (2-Trifluormethylphenyl)methyl, (3-Chlorphenyl)methyl, (4-Chlorphenyl)methyl, (3-Fluorphenyl)methyl, (4-Fluorphenyl)methyl, (2-Fluorphenyl)methyl, (3,4-Difluorphenyl)methyl, (3,4-Dichlorphenyl)methyl, (3-Fluor-4- chlorphenyl) methyl, (3-Chlor-4-fluorphenyl)methyl, (3,4-Dimethylphenyl)methyl, (3,5- Difluorphenyl)methyl, (3,5-Dichlorphenyl)methyl, (3-Fluor-5-chlorphenyl) methyl, (3-Chlor-5- fluorphenyl)methyl, (3,5-Dimethylphenyl)methyl, (3,5-Ditrifluormethylphenyl)methyl, (3- Fluor-5-trifluormethylphenyl) methyl, (3-Trifluormethyl-5-fluorphenyl)methyl, (3-Chlor-5- trifluormethylphenyl) methyl, (3-Trifluormethyl-5-Chlorphenyl)methyl steht, R 2 für eine der nachfolgenden Gruppen G-1 bis G-2 steht, wobei ein Pfeil für eine Bindung zum Pyrrolidinonring in der allgemeinen Formel (I) steht R 7 für Wasserstoff steht R 3 , R 4 unabhängig voneinander für Wasserstoff, (C 1 -C 8 )-Alkyl, (C 1 -C 10 )-Haloalkyl, (C 3 -C 10 )- Cycloalkyl, Aryl-(C 1 -C 8 )-Alkyl, Aryl stehen, R 5 , R 6 unabhängig voneinander für Wasserstoff, (C 1 -C 8 )-Alkyl, (C 2 -C 8 )-Alkenyl, (C 1 -C 10 )-Haloalkyl, (C 3 -C 10 )-Cycloalkyl, Aryl-(C 1 -C 8 )-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C 1 -C 8 )-Alkyl, Heterocyclyl, Heterocyclyl-(C 1 -C 8 )-Alkyl, R 32 O-(C 1 -C 8 )-Alkyl, R 30 R 31 N-(C 1 -C 8 )-Alkyl, NR 30 R 31 , OR 32 , (C 3 -C 10 )-Cycloalkyl-(C 1 -C 8 )-Alkyl stehen, R 13 , R 14 unabhängig voneinander für Wasserstoff, (C 1 -C 8 )-Alkyl, (C 2 -C 8 )-Alkenyl, (C 2 -C 8 )-Alkinyl, (C 1 -C 10 )-Haloalkyl, (C 3 -C 10 )-Cycloalkyl, Aryl-(C 1 -C 8 )-Alkyl, Aryl, Heteroaryl, Heteroaryl- (C 1 -C 8 )-Alkyl, Heterocyclyl, Heterocyclyl-(C 1 -C 8 )-Alkyl, R 32 O-(C 1 -C 8 )-Alkyl, R 30 R 31 N-(C 1 -C 8 )- Alkyl, (C 3 -C 10 )-Cycloalkyl-(C 1 -C 8 )-Alkyl, C(=O)R 32 , C(=O)OR 32 , C(=O)NR 30 R 31 , R 32 O(O)C- (C 1 -C 8 )-Alkyl, R 30 R 31 N(O)C-(C 1 -C 8 )-Alkyl, OR 32 stehen, R 15 für Wasserstoff, (C 1 -C 8 )-Alkyl, (C 2 -C 8 )-Alkenyl, (C 2 -C 8 )-Alkinyl, Aryl-(C 1 -C 8 )-Alkyl, Heteroaryl-(C 1 -C 8 )-Alkyl, Heterocyclyl-(C 1 -C 8 )-Alkyl, R 32 O-(C 1 -C 8 )-Alkyl, (C 3 -C 10 )- Cycloalkyl-(C 1 -C 8 )-Alkyl, S(O)mR 33 , R 32 (O=)C-(C 1 -C 8 )-Alkyl, C(O=)R 32 , R 32 O(O)C-(C 1 -C 8 )- Alkyl, R 30 R 31 N(O)C-(C 1 -C 8 )-Alkyl stehen, R 30 und R 31 unabhängig voneinander für Wasserstoff, (C 1 -C 8 )-Alkyl, (C 2 -C 8 )-Alkenyl, (C 2 -C 8 )-Alkinyl, (C 1 -C 8 )-Cyanoalkyl, (C 1 -C 10 )-Haloalkyl, (C 2 -C 8 )-Haloalkenyl, (C 3 -C 8 )-Haloalkinyl, (C 3 -C 10 )- Cycloalkyl, (C 3 -C 10 )-Halocycloalkyl, (C 4 -C 10 )-Cycloalkenyl, (C 4 -C 10 )-Halocycloalkenyl, (C 1 -C 8 )-Alkoxy-(C 1 -C 8 )-alkyl, (C 1 -C 8 )-Haloalkoxy-(C 1 -C 8 )-alkyl, (C 1 -C 8 )-Alkylthio-(C 1 -C 8 )- alkyl, (C 1 -C 8 )-Haloalkylthio-(C 1 -C 8 )-alkyl, (C 1 -C 8 )-Alkoxy-(C 1 -C 8 )-haloalkyl, Aryl, Aryl- (C 1 -C 8 )-alkyl, Heteroaryl, Heteroaryl-(C 1 -C 8 )-alkyl, (C 3 -C 8 )-Cycloalkyl-(C 1 -C 8 )-alkyl, (C 4 -C 10 )- Cycloalkenyl-(C 1 -C 8 )-alkyl, COR 32 , SO2R 33 , Heterocyclyl, (C 1 -C 8 )-Alkoxycarbonyl, Bis-[(C 1 - C 8 )-alkyl]aminocarbonyl-(C 1 -C 8 )-alkyl, (C 1 -C 8 )-Alkyl-aminocarbonyl-(C 1 -C 8 )-alkyl, Aryl-(C 1 - C 8 )-alkyl-aminocarbonyl-(C 1 -C 8 )-alkyl, Aryl-(C 1 -C 8 )-alkoxycarbonyl, Heteroaryl-(C 1 -C 8 )- alkoxycarbonyl, (C 2 -C 8 )-Alkenyloxycarbonyl, (C 2 -C 8 )-Alkinyloxycarbonyl, (C 1 -C 8 )- Alkoxycarbonyl-(C 1 -C 8 )-alkyl, (C 2 -C 8 )-Alkenyloxycarbonyl-(C 1 -C 8 )-alkyl, (C 2 -C 8 )- Alkinyloxycarbonyl-(C 1 -C 8 )-alkyl, Aryl-(C 1 -C 8 )-alkoxycarbonyl-(C 1 -C 8 )-alkyl, Heteroaryl-(C 1 -C 8 )-alkoxycarbonyl-(C 1 -C 8 )-alkyl, Heterocyclyl-(C 1 -C 8 )- alkoxycarbonyl-(C 1 -C 8 )-alkyl, Heterocyclyl-(C 1 -C 8 )-alkyl stehen, oder R 30 und R 31 mit dem Stickstoffatom, an das sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 3 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, R 32 für Wasserstoff, (C 1 -C 8 )-Alkyl, (C 2 -C 8 )-Alkenyl, (C 2 -C 8 )-Alkinyl, (C 1 -C 8 )-Cyanoalkyl, (C 1 -C 10 )- Haloalkyl, (C 2 -C 8 )-Haloalkenyl, (C 3 -C 8 )-Haloalkinyl, (C 3 -C 10 )-Cycloalkyl, (C 3 -C 10 )- Halocycloalkyl, (C 4 -C 10 )-Cycloalkenyl, (C 4 -C 10 )-Halocycloalkenyl, (C 1 -C 8 )-Alkoxy-(C 1 -C 8 )- alkyl, (C 1 -C 8 )-Haloalkoxy-(C 1 -C 8 )-alkyl, (C 1 -C 8 )-Alkoxy-(C 1 -C 8 )-haloalkyl, (C 1 -C 8 )-Alkoxy- (C 1 -C 8 )-alkoxy-(C 1 -C 8 )-alkyl, (C 1 -C 8 )-Alkoxy-(C 1 -C 8 )-alkoxy-(C 1 -C 8 )-alkoxy-(C 1 -C 8 )-alkyl, (C 1 -C 8 )-Alkoxy-(C 1 -C 8 )-alkoxy-(C 1 -C 8 )-alkoxy-(C 1 -C 8 )-alkoxy-(C 1 -C 8 )-alkyl, Aryl, Aryl- (C 1 -C 8 )-alkyl, Aryl-(C 1 -C 8 )-alkoxy-(C 1 -C 8 )-alkyl, Heteroaryl, Heteroaryl-(C 1 -C 8 )-alkyl, (C 3 -C 8 )- Cycloalkyl-(C 1 -C 8 )-alkyl, (C 4 -C 10 )-Cycloalkenyl-(C 1 -C 8 )-alkyl, Bis-[(C 1 -C 8 )- alkyl]aminocarbonyl-(C 1 -C 8 )-alkyl, (C 1 -C 8 )-Alkyl-aminocarbonyl-(C 1 -C 8 )-alkyl, Aryl-(C 1 -C 8 )- alkyl-aminocarbonyl-(C 1 -C 8 )-alkyl, Bis-[(C 1 -C 8 )-alkyl]amino-(C 2 -C 6 )-alkyl, (C 1 -C 8 )-Alkyl- amino-(C 2 -C 6 )-alkyl, Aryl-(C 1 -C 8 )-alkyl-amino-(C 2 -C 6 )-alkyl, R 33 (O)mS-(C 1 -C 8 )-alkyl, Hydroxycarbonyl-(C 1 -C 8 )-alkyl, Heterocyclyl, Heterocyclyl-(C 1 -C 8 )-alkyl, Tris-[(C 1 -C 8 )- Alkyl]silyl-(C 1 -C 8 )-alkyl, Bis-[(C 1 -C 8 )-Alkyl](aryl)silyl(C 1 -C 8 )-alkyl, [(C 1 -C 8 )-Alkyl]-bis- (aryl)silyl-(C 1 -C 8 )-alkyl, (C 1 -C 8 )-Alkylcarbonyloxy-(C 1 -C 8 )-alkyl, (C 3 -C 8 )- Cycloalkylcarbonyloxy-(C 1 -C 8 )-alkyl, Arylcarbonyloxy-(C 1 -C 8 )-alkyl, Heteroarylcarbonyloxy- (C 1 -C 8 )-alkyl, Heterocyclylcarbonyloxy-(C 1 -C 8 )-alkyl, Aryloxy-(C 1 -C 8 )-alkyl, Heteroaryloxy- (C 1 -C 8 )-alkyl, Heterocyclyloxy-(C 1 -C 8 )-alkyl, (C 1 -C 8 )-Alkoxycarbonyl, (C 1 -C 8 )- Alkoxycarbonyl-(C 1 -C 8 )-alkyl, (C 2 -C 8 )-Alkenyloxycarbonyl-(C 1 -C 8 )-alkyl, (C 2 -C 8 )- Alkinyloxycarbonyl-(C 1 -C 8 )-alkyl, Aryl-(C 1 -C 8 )-alkoxycarbonyl-(C 1 -C 8 )-alkyl, Heteroaryl-(C 1 -C 8 )-alkoxycarbonyl-(C 1 -C 8 )-alkyl, Heterocyclyl-(C 1 -C 8 )- alkoxycarbonyl-(C 1 -C 8 )-alkyl steht und R 33 für Wasserstoff, (C 1 -C 8 )-Alkyl, (C 2 -C 8 )-Alkenyl, (C 2 -C 8 )-Alkinyl, (C 1 -C 8 )-Cyanoalkyl, (C 1 -C 10 )- Haloalkyl, (C 2 -C 8 )-Haloalkenyl, (C 3 -C 8 )-Haloalkinyl, (C 3 -C 10 )-Cycloalkyl, (C 3 -C 10 )- Halocycloalkyl, (C 4 -C 10 )-Cycloalkenyl, (C 4 -C 10 )-Halocycloalkenyl, (C 1 -C 8 )-Alkoxy-(C 1 -C 8 )- alkyl, (C 1 -C 8 )-Alkoxy-(C 1 -C 8 )-haloalkyl, Aryl, Aryl-(C 1 -C 8 )-alkyl, Heteroaryl, Heteroaryl- (C 1 -C 8 )-alkyl, Heterocyclyl-(C 1 -C 8 )-alkyl, (C 3 -C 8 )-Cycloalkyl-(C 1 -C 8 )-alkyl, (C 4 -C 10 )- Cycloalkenyl-(C 1 -C 8 )-alkyl, Bis-[(C 1 -C 8 )-alkyl]amino, (C 1 -C 8 )-Alkyl-amino, Aryl-(C 1 -C 8 )- amino, Aryl-(C 1 -C 6 )-alkyl-amino, Aryl-[(C 1 -C 8 )-alkyl]amino; Heteroaryl-(C 1 -C 8 )-amino, Heteroaryl-(C 1 -C 6 )-alkyl-amino, Heteroaryl-[(C 1 -C 8 )-alkyl]amino; Hetercyclyl-(C 1 -C 8 )-amino, Heterocyclyl-(C 1 -C 6 )-alkyl-amino, Heterocyclyl-[(C 1 -C 8 )-alkyl]amino; (C 3 -C 8 )-Cycloalkyl- amino, (C 3 -C 8 )-Cycloalkyl-[(C 1 -C 8 )-alkyl]amino; N-Azetidinyl, N-Pyrrolidinyl, N-Piperidinyl. N-Morpholinyl steht. R 35 für Wasserstoff, NR 30 R 31 , OR 32 , (C 1 -C 8 )-Alkyl, (C 2 -C 8 )-Alkenyl, (C 2 -C 8 )-Alkinyl, Aryl, Aryl- (C 1 -C 8 )-Alkyl, Heteroaryl, Heteroaryl-(C 1 -C 8 )-Alkyl, Heterocyclyl, Heterocyclyl-(C 1 -C 8 )-Alkyl, R 32 O-(C 1 -C 8 )-Alkyl, (C 3 -C 10 )-Cycloalkyl, (C 3 -C 10 )-Cycloalkyl-(C 1 -C 8 )-Alkyl, S(O) m R 33 , R 32 (O=)C-(C 1 -C 8 )-Alkyl, R 32 O(O)C-(C 1 -C 8 )-Alkyl, R 30 R 31 N(O)C-(C 1 -C 8 )-Alkyl, R 33 S(O) m - (C 1 -C 8 )-alkyl, R 32 O-(C 1 -C 8 )-Alkyl, R 30 R 31 N-(C 1 -C 8 )-Alkyl steht, R 36 für Wasserstoff, (C 1 -C 8 )-Alkyl, (C 2 -C 8 )-Alkenyl, (C 2 -C 8 )-Alkinyl, Aryl, Aryl-(C 1 -C 8 )-Alkyl, Heteroaryl, Heteroaryl-(C 1 -C 8 )-Alkyl, Heterocyclyl, Heterocyclyl-(C 1 -C 8 )-Alkyl, (C 3 -C 10 )- Cycloalkyl, (C 3 -C 10 )-Cycloalkyl-(C 1 -C 8 )-Alkyl, R 32 (O=)C-(C 1 -C 8 )-Alkyl, R 32 O(O)C-(C 1 -C 8 )- Alkyl, R 30 R 31 N(O)C-(C 1 -C 8 )-Alkyl, R 33 S(O)m-(C 1 -C 8 )-alkyl, R 32 O-(C 1 -C 8 )-Alkyl, R 30 R 31 N- (C 1 -C 8 )-Alkyl steht und m für 0, 1, 2 steht. Bevorzugt sind Verbindungen der allgemeinen Formel (I), worin R 1 für (3-Methylphenyl)methyl, (4-Methylphenyl)methyl, (2-Methylphenyl)methyl, (3- Trifluormethylphenyl)methyl, (4-Trifluorethylphenyl)methyl, (2-Trifluormethylphenyl)methyl, (3-Chlorphenyl)methyl, (4-Chlorphenyl)methyl, (3-Fluorphenyl)methyl, (4-Fluorphenyl)methyl, (2-Fluorphenyl)methyl, (3,4-Difluorphenyl)methyl, (3,4-Dichlorphenyl)methyl, (3-Fluor-4- chlorphenyl) methyl, (3-Chlor-4-fluorphenyl)methyl, (3,4-Dimethylphenyl)methyl, (3,5- Difluorphenyl)methyl, (3,5-Dichlorphenyl)methyl, (3-Fluor-5-chlorphenyl) methyl, (3-Chlor-5- fluorphenyl)methyl, (3,5-Dimethylphenyl)methyl, (3,5-Ditrifluormethylphenyl)methyl, (3- Fluor-5-trifluormethylphenyl) methyl, (3-Trifluormethyl-5-fluorphenyl)methyl, (3-Chlor-5- trifluormethylphenyl) methyl, (3-Trifluormethyl-5-Chlorphenyl)methyl steht, R 2 für eine der nachfolgenden Gruppen G-1 bis G-2 steht, wobei ein Pfeil für eine Bindung zum Pyrrolidinonring in der allgemeinen Formel (I) steht G-1 G-2 R 7 für Wasserstoff steht R 3 , R 4 unabhängig voneinander für Wasserstoff, (C 1 -C 7 )-Alkyl, (C 1 -C 7 )-Haloalkyl, (C 3 -C 7 )-Cycloalkyl, Aryl-(C 1 -C 7 )-Alkyl, Aryl stehen, R 5 , R 6 unabhängig voneinander für Wasserstoff, (C 1 -C 7 )-Alkyl, (C 2 -C 7 )-Alkenyl, (C 1 -C 7 )-Haloalkyl, (C 3 -C 7 )-Cycloalkyl, Aryl-(C 1 -C 7 )-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C 1 -C 7 )-Alkyl, Heterocyclyl, Heterocyclyl-(C 1 -C 7 )-Alkyl, R 32 O-(C 1 -C 7 )-Alkyl, R 30 R 31 N-(C 1 -C 7 )-Alkyl, NR 30 R 31 , OR 32 , (C 3 -C 7 )-Cycloalkyl-(C 1 -C 7 )-Alkyl stehen, R 13 , R 14 unabhängig voneinander für Wasserstoff, (C 1 -C 8 )-Alkyl, (C 2 -C 8 )-Alkenyl, (C 2 -C 8 )-Alkinyl, (C 1 -C 7 )-Haloalkyl, (C 3 -C 7 )-Cycloalkyl, Aryl-(C 1 -C 7 )-Alkyl, Aryl, Heteroaryl, Heteroaryl- (C 1 -C 7 )-Alkyl, Heterocyclyl, Heterocyclyl-(C 1 -C 7 )-Alkyl, R 32 O-(C 1 -C 7 )-Alkyl, R 30 R 31 N-(C 1 -C 7 )- Alkyl, (C 3 -C 7 )-Cycloalkyl-(C 1 -C 7 )-Alkyl, C(=O)R 32 , C(=O)OR 32 , C(=O)NR 30 R 31 , R 32 O(O)C- (C 1 -C 7 )-Alkyl, R 30 R 31 N(O)C-(C 1 -C 7 )-Alkyl, OR 32 stehen, R 15 für Wasserstoff, (C 1 -C 7 )-Alkyl, (C 2 -C 7 )-Alkenyl, (C 2 -C 7 )-Alkinyl, Aryl-(C 1 -C 7 )-Alkyl, Heteroaryl-(C 1 -C 7 )-Alkyl, Heterocyclyl-(C 1 -C 7 )-Alkyl, R 32 O-(C 1 -C 7 )-Alkyl, (C 3 -C 7 )-Cycloalkyl- (C 1 -C 7 )-Alkyl, S(O) m R 33 , R 32 (O=)C-(C 1 -C 7 )-Alkyl, C(O=)R 32 , R 32 O(O)C-(C 1 -C 7 )-Alkyl, R 30 R 31 N(O)C-(C 1 -C 7 )-Alkyl stehen, R 30 und R 31 unabhängig voneinander für Wasserstoff, (C 1 -C 7 )-Alkyl, (C 2 -C 7 )-Alkenyl, (C 2 -C 7 )-Alkinyl, (C 1 -C 7 )-Cyanoalkyl, (C 1 -C 10 )-Haloalkyl, (C 2 -C 7 )-Haloalkenyl, (C 3 -C 7 )-Haloalkinyl, (C 3 -C 7 )- Cycloalkyl, (C 3 -C 7 )-Halocycloalkyl, (C 4 -C 7 )-Cycloalkenyl, (C 4 -C 10 )-Halocycloalkenyl, (C 1 -C 7 )- Alkoxy-(C 1 -C 7 )-alkyl, (C 1 -C 7 )-Haloalkoxy-(C 1 -C 7 )-alkyl, (C 1 -C 7 )-Alkylthio-(C 1 -C 7 )-alkyl, (C 1 -C 7 )-Haloalkylthio-(C 1 -C 7 )-alkyl, (C 1 -C 7 )-Alkoxy-(C 1 -C 7 )-haloalkyl, Aryl, Aryl-(C 1 -C 7 )- alkyl, Heteroaryl, Heteroaryl-(C 1 -C 7 )-alkyl, (C 3 -C 7 )-Cycloalkyl-(C 1 -C 7 )-alkyl, (C 4 -C 7 )- Cycloalkenyl-(C 1 -C 7 )-alkyl, COR 32 , SO2R 33 , Heterocyclyl, (C 1 -C 7 )-Alkoxycarbonyl, Bis-[(C 1 - C7)-alkyl]aminocarbonyl-(C 1 -C 7 )-alkyl, (C 1 -C 7 )-Alkyl-aminocarbonyl-(C 1 -C 7 )-alkyl, Aryl-(C 1 - C7)-alkyl-aminocarbonyl-(C 1 -C 7 )-alkyl, Aryl-(C 1 -C 7 )-alkoxycarbonyl, Heteroaryl-(C 1 -C 7 )- alkoxycarbonyl, (C 2 -C 7 )-Alkenyloxycarbonyl, (C 2 -C 7 )-Alkinyloxycarbonyl, (C 1 -C 7 )- Alkoxycarbonyl-(C 1 -C 7 )-alkyl, (C 2 -C 7 )-Alkenyloxycarbonyl-(C 1 -C 7 )-alkyl, (C 2 -C 7 )- Alkinyloxycarbonyl-(C 1 -C 7 )-alkyl, Aryl-(C 1 -C 7 )-alkoxycarbonyl-(C 1 -C 7 )-alkyl, Heteroaryl- (C 1 -C 7 )-alkoxycarbonyl-(C 1 -C 7 )-alkyl, Heterocyclyl-(C 1 -C 7 )-alkoxycarbonyl-(C 1 -C 7 )-alkyl, Heterocyclyl-(C 1 -C 7 )-alkyl stehen, oder R 30 und R 31 mit dem Stickstoffatom, an das sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 3 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, R 32 für Wasserstoff, (C 1 -C 7 )-Alkyl, (C 2 -C 7 )-Alkenyl, (C 2 -C 7 )-Alkinyl, (C 1 -C 7 )-Cyanoalkyl, (C 1 -C 10 )- Haloalkyl, (C 2 -C 7 )-Haloalkenyl, (C 3 -C 7 )-Haloalkinyl, (C 3 -C 7 )-Cycloalkyl, (C 3 -C 7 )- Halocycloalkyl, (C 4 -C 7 )-Cycloalkenyl, (C 4 -C 10 )-Halocycloalkenyl, (C 1 -C 7 )-Alkoxy-(C 1 -C 7 )- alkyl, (C 1 -C 7 )-Haloalkoxy-(C 1 -C 7 )-alkyl, (C 1 -C 7 )-Alkoxy-(C 1 -C 7 )-haloalkyl, (C 1 -C 7 )-Alkoxy- (C 1 -C 7 )-alkoxy-(C 1 -C 7 )-alkyl, (C 1 -C 7 )-Alkoxy-(C 1 -C 7 )-alkoxy-(C 1 -C 7 )-alkoxy-(C 1 -C 7 )-alkyl, (C 1 -C 7 )-Alkoxy-(C 1 -C 7 )-alkoxy-(C 1 -C 7 )-alkoxy-(C 1 -C 7 )-alkoxy-(C 1 -C 7 )-alkyl, Aryl, Aryl- (C 1 -C 7 )-alkyl, Aryl-(C 1 -C 7 )-alkoxy-(C 1 -C 7 )-alkyl, Heteroaryl, Heteroaryl-(C 1 -C 7 )-alkyl, (C 3 -C 7 )- Cycloalkyl-(C 1 -C 7 )-alkyl, (C 4 -C 10 )-Cycloalkenyl-(C 1 -C 7 )-alkyl, Bis-[(C 1 -C 7 )- alkyl]aminocarbonyl-(C 1 -C 7 )-alkyl, (C 1 -C 7 )-Alkyl-aminocarbonyl-(C 1 -C 7 )-alkyl, Aryl-(C 1 -C 7 )- alkyl-aminocarbonyl-(C 1 -C 7 )-alkyl, Bis-[(C 1 -C 7 )-alkyl]amino-(C 2 -C 6 )-alkyl, (C 1 -C 7 )-Alkyl- amino-(C 2 -C 6 )-alkyl, Aryl-(C 1 -C 7 )-alkyl-amino-(C 2 -C 6 )-alkyl, R 33 (O)mS-(C 1 -C 7 )-alkyl, Hydroxycarbonyl-(C 1 -C 7 )-alkyl, Heterocyclyl, Heterocyclyl-(C 1 -C 7 )-alkyl, Tris-[(C 1 -C 7 )- Alkyl]silyl-(C 1 -C 7 )-alkyl, Bis-[(C 1 -C 7 )-Alkyl](aryl)silyl(C 1 -C 7 )-alkyl, [(C 1 -C 7 )-Alkyl]-bis- (aryl)silyl-(C 1 -C 7 )-alkyl, (C 1 -C 7 )-Alkylcarbonyloxy-(C 1 -C 7 )-alkyl, (C 3 -C 7 )- Cycloalkylcarbonyloxy-(C 1 -C 7 )-alkyl, Arylcarbonyloxy-(C 1 -C 7 )-alkyl, Heteroarylcarbonyloxy- (C 1 -C 7 )-alkyl, Heterocyclylcarbonyloxy-(C 1 -C 7 )-alkyl, Aryloxy-(C 1 -C 7 )-alkyl, Heteroaryloxy- (C 1 -C 7 )-alkyl, Heterocyclyloxy-(C 1 -C 7 )-alkyl, (C 1 -C 7 )-Alkoxycarbonyl, (C1-C7)- Alkoxycarbonyl-(C 1 -C 7 )-alkyl, (C 2 -C 7 )-Alkenyloxycarbonyl-(C 1 -C 7 )-alkyl, (C 2 -C 7 )- Alkinyloxycarbonyl-(C 1 -C 7 )-alkyl, Aryl-(C 1 -C 7 )-alkoxycarbonyl-(C 1 -C 7 )-alkyl, Heteroaryl-(C 1 -C 7 )-alkoxycarbonyl-(C 1 -C 7 )-alkyl, Heterocyclyl-(C 1 -C 7 )- alkoxycarbonyl-(C 1 -C 7 )-alkyl steht und R 33 für Wasserstoff, (C 1 -C 7 )-Alkyl, (C 2 -C 7 )-Alkenyl, (C 2 -C 7 )-Alkinyl, (C 1 -C 7 )-Cyanoalkyl, (C 1 -C 10 )- Haloalkyl, (C 2 -C 7 )-Haloalkenyl, (C 3 -C 7 )-Haloalkinyl, (C 3 -C 7 )-Cycloalkyl, (C 3 -C 7 )- Halocycloalkyl, (C 4 -C 7 )-Cycloalkenyl, (C 4 -C 7 )-Halocycloalkenyl, (C 1 -C 7 )-Alkoxy-(C 1 -C 7 )-alkyl, (C 1 -C 7 )-Alkoxy-(C 1 -C 7 )-haloalkyl, Aryl, Aryl-(C 1 -C 7 )-alkyl, Heteroaryl, Heteroaryl-(C 1 -C 7 )- alkyl, Heterocyclyl-(C 1 -C 7 )-alkyl, (C 3 -C 7 )-Cycloalkyl-(C 1 -C 7 )-alkyl, (C 4 -C 10 )-Cycloalkenyl- (C 1 -C 7 )-alkyl, Bis-[(C 1 -C 7 )-alkyl]amino, (C 1 -C 7 )-Alkyl-amino, Aryl-(C 1 -C 7 )-amino, Aryl-(C 1 - C 6 )-alkyl-amino, Aryl-[(C 1 -C 7 )-alkyl]amino; Heteroaryl-(C 1 -C 7 )-amino, Heteroaryl-(C 1 -C 6 )- alkyl-amino, Heteroaryl-[(C 1 -C 7 )-alkyl]amino; Hetercyclyl-(C 1 -C 7 )-amino, Heterocyclyl-(C 1 - C 6 )-alkyl-amino, Heterocyclyl-[(C 1 -C 7 )-alkyl]amino; (C 3 -C 7 )-Cycloalkyl-amino, (C 3 -C 7 )- Cycloalkyl-[(C 1 -C 7 )-alkyl]amino; N-Azetidinyl, N-Pyrrolidinyl, N-Piperidinyl. N-Morpholinyl steht. R 35 für Wasserstoff, NR 30 R 31 , OR 32 , (C 1 -C 7 )-Alkyl, (C 2 -C 7 )-Alkenyl, (C 2 -C 7 )-Alkinyl, Aryl, Aryl- (C 1 -C 7 )-Alkyl, Heteroaryl, Heteroaryl-(C 1 -C 7 )-Alkyl, Heterocyclyl, Heterocyclyl-(C 1 -C 7 )-Alkyl, R 32 O-(C 1 -C 7 )-Alkyl, (C 3 -C 7 )-Cycloalkyl, (C 3 -C 7 )-Cycloalkyl-(C 1 -C 7 )-Alkyl, S(O)mR 33 , R 32 (O=)C-(C 1 -C 7 )-Alkyl, R 32 O(O)C-(C 1 -C 7 )-Alkyl, R 30 R 31 N(O)C-(C 1 -C 7 )-Alkyl, R 33 S(O)m- (C 1 -C 7 )-alkyl, R 32 O-(C 1 -C 7 )-Alkyl, R 30 R 31 N-(C 1 -C 7 )-Alkyl steht, R 36 für Wasserstoff, (C 1 -C 7 )-Alkyl, (C 2 -C 7 )-Alkenyl, (C 2 -C 7 )-Alkinyl, Aryl, Aryl-(C 1 -C 7 )-Alkyl, Heteroaryl, Heteroaryl-(C 1 -C 7 )-Alkyl, Heterocyclyl, Heterocyclyl-(C 1 -C 7 )-Alkyl, (C 3 -C 7 )- Cycloalkyl, (C 3 -C 7 )-Cycloalkyl-(C 1 -C 7 )-Alkyl, R 32 (O=)C-(C 1 -C 7 )-Alkyl, R 32 O(O)C-(C 1 -C 7 )- Alkyl, R 30 R 31 N(O)C-(C 1 -C 7 )-Alkyl, R 33 S(O)m-(C 1 -C 7 )-alkyl, R 32 O-(C 1 -C 7 )-Alkyl, R 30 R 31 N- (C 1 -C 7 )-Alkyl steht und m für 0, 1, 2 steht. Besonders bevorzugt sind Verbindungen der allgemeinen Formel (I), worin R 1 für (3-Methylphenyl)methyl, (4-Methylphenyl)methyl, (2-Methylphenyl)methyl, (3- Trifluormethylphenyl)methyl, (4-Trifluorethylphenyl)methyl, (2-Trifluormethylphenyl)methyl, (3-Chlorphenyl)methyl, (4-Chlorphenyl)methyl, (3-Fluorphenyl)methyl, (4-Fluorphenyl)methyl, (2-Fluorphenyl)methyl, (3,4-Difluorphenyl)methyl, (3,4-Dichlorphenyl)methyl, (3-Fluor-4- chlorphenyl) methyl, (3-Chlor-4-fluorphenyl)methyl, (3,4-Dimethylphenyl)methyl, (3,5- Difluorphenyl)methyl, (3,5-Dichlorphenyl)methyl, (3-Fluor-5-chlorphenyl) methyl, (3-Chlor-5- fluorphenyl)methyl, (3,5-Dimethylphenyl)methyl, (3,5-Ditrifluormethylphenyl)methyl, (3- Fluor-5-trifluormethylphenyl) methyl, (3-Trifluormethyl-5-fluorphenyl)methyl, (3-Chlor-5- trifluormethylphenyl) methyl, (3-Trifluormethyl-5-Chlorphenyl)methyl steht, R 2 für eine der nachfolgenden Gruppen G-1 bis G-2 steht, wobei ein Pfeil für eine Bindung zum Pyrrolidinonring in der allgemeinen Formel (I) steht, R 7 für Wasserstoff steht, R 3 , R 4 unabhängig voneinander für Wasserstoff, (C 1 -C 6 )-Alkyl, (C 1 -C 6 )-Haloalkyl, (C 3 -C 6 )-Cycloalkyl, Aryl-(C 1 -C 6 )-Alkyl,, Aryl stehen, R 5 , R 6 unabhängig voneinander für Wasserstoff, (C 1 -C 6 )-Alkyl, (C 2 -C 6 )-Alkenyl, (C 1 -C 6 )-Haloalkyl, (C 3 -C 6 )-Cycloalkyl, Aryl-(C 1 -C 6 )-Alkyl, Aryl, Heteroaryl, Heteroaryl-(C 1 -C 6 )-Alkyl, Heterocyclyl, Heterocyclyl-(C 1 -C 6 )-Alkyl, R 32 O-(C 1 -C 6 )-Alkyl, R 30 R 31 N-(C 1 -C 6 )-Alkyl, NR 30 R 31 , OR 32 , (C 3 -C 6 )-Cycloalkyl-(C 1 -C 6 )-Alkyl stehen, R 13 , R 14 unabhängig voneinander für Wasserstoff, (C 1 -C 8 )-Alkyl, (C 2 -C 8 )-Alkenyl, (C 2 -C 8 )-Alkinyl, (C 1 -C 6 )-Haloalkyl, (C 3 -C 6 )-Cycloalkyl, Aryl-(C 1 -C 6 )-Alkyl, Aryl, Heteroaryl, Heteroaryl- (C 1 -C 6 )-Alkyl, Heterocyclyl, Heterocyclyl-(C 1 -C 6 )-Alkyl, R 32 O-(C 1 -C 6 )-Alkyl, R 30 R 31 N-(C 1 -C 6 )- Alkyl, (C 3 -C 6 )-Cycloalkyl-(C 1 -C 6 )-Alkyl, C(=O)R 32 , C(=O)OR 32 , C(=O)NR 30 R 31 , R 32 O(O)C- (C 1 -C 6 )-Alkyl, R 30 R 31 N(O)C-(C 1 -C 6 )-Alkyl, OR 32 stehen, R 15 für Wasserstoff, (C 1 -C 6 )-Alkyl, (C 2 -C 6 )-Alkenyl, (C 2 -C 6 )-Alkinyl, Aryl-(C 1 -C 6 )-Alkyl, Heteroaryl-(C 1 -C 6 )-Alkyl, Heterocyclyl-(C 1 -C 6 )-Alkyl, R 32 O-(C 1 -C 6 )-Alkyl, (C 3 -C 6 )-Cycloalkyl- (C 1 -C 6 )-Alkyl, S(O)mR 33 , R 32 (O=)C-(C 1 -C 6 )-Alkyl, C(O=)R 32 , R 32 O(O)C-(C 1 -C 6 )-Alkyl, R 30 R 31 N(O)C-(C 1 -C 6 )-Alkyl stehen, R 30 und R 31 unabhängig voneinander für Wasserstoff, (C 1 -C 6 )-Alkyl, (C 2 -C 6 )-Alkenyl, (C 2 -C 6 )-Alkinyl, (C 1 -C 6 )-Cyanoalkyl, (C 1 -C 10 )-Haloalkyl, (C 2 -C 6 )-Haloalkenyl, (C 3 -C 6 )-Haloalkinyl, (C 3 -C 6 )- Cycloalkyl, (C 3 -C 6 )-Halocycloalkyl, (C 4 -C 6 )-Cycloalkenyl, (C 4 -C 10 )-Halocycloalkenyl, (C 1 -C 6 )- Alkoxy-(C 1 -C 6 )-alkyl, (C 1 -C 6 )-Haloalkoxy-(C 1 -C 6 )-alkyl, (C 1 -C 6 )-Alkylthio-(C 1 -C 6 )-alkyl, (C 1 -C 6 )-Haloalkylthio-(C 1 -C 6 )-alkyl, (C 1 -C 6 )-Alkoxy-(C 1 -C 6 )-haloalkyl, Aryl, Aryl-(C 1 -C 6 )- alkyl, Heteroaryl, Heteroaryl-(C 1 -C 6 )-alkyl, (C 3 -C 6 )-Cycloalkyl-(C 1 -C 6 )-alkyl, (C 4 -C 6 )- Cycloalkenyl-(C 1 -C 6 )-alkyl, COR 32 , SO2R 33 , Heterocyclyl, (C 1 -C 6 )-Alkoxycarbonyl, Bis-[(C 1 - C 6 )-alkyl]aminocarbonyl-(C 1 -C 6 )-alkyl, (C 1 -C 6 )-Alkyl-aminocarbonyl-(C 1 -C 6 )-alkyl, Aryl-(C 1 - C 6 )-alkyl-aminocarbonyl-(C 1 -C 6 )-alkyl, Aryl-(C 1 -C 6 )-alkoxycarbonyl, Heteroaryl-(C 1 -C 6 )- alkoxycarbonyl, (C 2 -C 6 )-Alkenyloxycarbonyl, (C 2 -C 6 )-Alkinyloxycarbonyl, (C 1 -C 6 )- Alkoxycarbonyl-(C 1 -C 6 )-alkyl, (C 2 -C 6 )-Alkenyloxycarbonyl-(C 1 -C 6 )-alkyl, (C 2 -C 6 )- Alkinyloxycarbonyl-(C 1 -C 6 )-alkyl, Aryl-(C 1 -C 6 )-alkoxycarbonyl-(C 1 -C 6 )-alkyl, Heteroaryl-(C 1 -C 6 )-alkoxycarbonyl-(C 1 -C 6 )-alkyl, Heterocyclyl-(C 1 -C 6 )- alkoxycarbonyl-(C 1 -C 6 )-alkyl, Heterocyclyl-(C 1 -C 6 )-alkyl stehen, oder R 30 und R 31 mit dem Stickstoffatom, an das sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 3 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, R 32 für Wasserstoff, (C 1 -C 6 )-Alkyl, (C 2 -C 6 )-Alkenyl, (C 2 -C 6 )-Alkinyl, (C 1 -C 6 )-Cyanoalkyl, (C 1 -C 10 )- Haloalkyl, (C 2 -C 6 )-Haloalkenyl, (C 3 -C 6 )-Haloalkinyl, (C 3 -C 6 )-Cycloalkyl, (C 3 -C 6 )- Halocycloalkyl, (C 4 -C 6 )-Cycloalkenyl, (C 4 -C 10 )-Halocycloalkenyl, (C 1 -C 6 )-Alkoxy-(C 1 -C 6 )- alkyl, (C 1 -C 6 )-Haloalkoxy-(C 1 -C 6 )-alkyl, (C 1 -C 6 )-Alkoxy-(C 1 -C 6 )-haloalkyl, (C 1 -C 6 )-Alkoxy- (C 1 -C 6 )-alkoxy-(C 1 -C 6 )-alkyl, (C 1 -C 6 )-Alkoxy-(C 1 -C 6 )-alkoxy-(C 1 -C 6 )-alkoxy-(C 1 -C 6 )-alkyl, (C 1 -C 6 )-Alkoxy-(C 1 -C 6 )-alkoxy-(C 1 -C 6 )-alkoxy-(C 1 -C 6 )-alkoxy-(C 1 -C 6 )-alkyl, Aryl, Aryl- (C 1 -C 6 )-alkyl, Aryl-(C 1 -C 6 )-alkoxy-(C 1 -C 6 )-alkyl, Heteroaryl, Heteroaryl-(C 1 -C 6 )-alkyl, (C 3 -C 6 )- Cycloalkyl-(C 1 -C 6 )-alkyl, (C 4 -C 6 )-Cycloalkenyl-(C 1 -C 6 )-alkyl, Bis-[(C 1 -C 6 )- alkyl]aminocarbonyl-(C 1 -C 6 )-alkyl, (C 1 -C 6 )-Alkyl-aminocarbonyl-(C 1 -C 6 )-alkyl, Aryl-(C 1 -C 6 )- alkyl-aminocarbonyl-(C 1 -C 6 )-alkyl, Bis-[(C 1 -C 6 )-alkyl]amino-(C 2 -C 6 )-alkyl, (C 1 -C 6 )-Alkyl- amino-(C 2 -C 6 )-alkyl, Aryl-(C 1 -C 6 )-alkyl-amino-(C 2 -C 6 )-alkyl, R 33 (O) m S-(C 1 -C 6 )-alkyl, Hydroxycarbonyl-(C 1 -C 6 )-alkyl, Heterocyclyl, Heterocyclyl-(C 1 -C 6 )-alkyl, Tris-[(C 1 -C 6 )- Alkyl]silyl-(C 1 -C 6 )-alkyl, Bis-[(C 1 -C 6 )-Alkyl](aryl)silyl(C 1 -C 6 )-alkyl, [(C 1 -C 6 )-Alkyl]-bis- (aryl)silyl-(C 1 -C 6 )-alkyl, (C 1 -C 6 )-Alkylcarbonyloxy-(C 1 -C 6 )-alkyl, (C 3 -C 6 )- Cycloalkylcarbonyloxy-(C 1 -C 6 )-alkyl, Arylcarbonyloxy-(C 1 -C 6 )-alkyl, Heteroarylcarbonyloxy- (C 1 -C 6 )-alkyl, Heterocyclylcarbonyloxy-(C 1 -C 6 )-alkyl, Aryloxy-(C 1 -C 6 )-alkyl, Heteroaryloxy- (C 1 -C 6 )-alkyl, Heterocyclyloxy-(C 1 -C 6 )-alkyl, (C 1 -C 6 )-Alkoxycarbonyl, (C 1 -C 6 )- Alkoxycarbonyl-(C 1 -C 6 )-alkyl, (C 2 -C 6 )-Alkenyloxycarbonyl-(C 1 -C 6 )-alkyl, (C 2 -C 6 )- Alkinyloxycarbonyl-(C 1 -C 6 )-alkyl, Aryl-(C 1 -C 6 )-alkoxycarbonyl-(C 1 -C 6 )-alkyl, Heteroaryl-(C 1 -C 6 )-alkoxycarbonyl-(C 1 -C 6 )-alkyl, Heterocyclyl-(C 1 -C 6 )- alkoxycarbonyl-(C 1 -C 6 )-alkyl steht, R 33 für Wasserstoff, (C 1 -C 6 )-Alkyl, (C 2 -C 6 )-Alkenyl, (C 2 -C 6 )-Alkinyl, (C 1 -C 6 )-Cyanoalkyl, (C 1 -C 10 )- Haloalkyl, (C 2 -C 6 )-Haloalkenyl, (C 3 -C 6 )-Haloalkinyl, (C 3 -C 6 )-Cycloalkyl, (C 3 -C 6 )- Halocycloalkyl, (C 4 -C 6 )-Cycloalkenyl, (C 4 -C 6 )-Halocycloalkenyl, (C 1 -C 6 )-Alkoxy-(C 1 -C 6 )-alkyl, (C 1 -C 6 )-Alkoxy-(C 1 -C 6 )-haloalkyl, Aryl, Aryl-(C 1 -C 6 )-alkyl, Heteroaryl, Heteroaryl-(C 1 -C 6 )- alkyl, Heterocyclyl-(C 1 -C 6 )-alkyl, (C 3 -C 6 )-Cycloalkyl-(C 1 -C 6 )-alkyl, (C 4 -C 6 )-Cycloalkenyl- (C 1 -C 6 )-alkyl, Bis-[(C 1 -C 6 )-alkyl]amino, (C 1 -C 6 )-Alkyl-amino, Aryl-(C 1 -C 6 )-amino, Aryl-(C 1 - C 6 )-alkyl-amino, Aryl-[(C 1 -C 6 )-alkyl]amino; Heteroaryl-(C 1 -C 6 )-amino, Heteroaryl-(C 1 -C 6 )- alkyl-amino, Heteroaryl-[(C 1 -C 6 )-alkyl]amino; Hetercyclyl-(C 1 -C 6 )-amino, Heterocyclyl-(C 1 - C 6 )-alkyl-amino, Heterocyclyl-[(C 1 -C 6 )-alkyl]amino; (C 3 -C 6 )-Cycloalkyl-amino, (C 3 -C 6 )- Cycloalkyl-[(C 1 -C 6 )-alkyl]amino; N-Azetidinyl, N-Pyrrolidinyl, N-Piperidinyl. N-Morpholinyl steht, R 35 für Wasserstoff, NR 30 R 31 , OR 32 , (C 1 -C 6 )-Alkyl, (C 2 -C 6 )-Alkenyl, (C 2 -C 6 )-Alkinyl, Aryl, Aryl- (C 1 -C 6 )-Alkyl, Heteroaryl, Heteroaryl-(C 1 -C 6 )-Alkyl, Heterocyclyl, Heterocyclyl-(C 1 -C 6 )-Alkyl, R 32 O-(C 1 -C 6 )-Alkyl, (C 3 -C 6 )-Cycloalkyl, (C 3 -C 6 )-Cycloalkyl-(C 1 -C 6 )-Alkyl, S(O)mR 33 , R 32 (O=)C-(C 1 -C 6 )-Alkyl, R 32 O(O)C-(C 1 -C 6 )-Alkyl, R 30 R 31 N(O)C-(C 1 -C 6 )-Alkyl, R 33 S(O)m- (C 1 -C 6 )-alkyl, R 32 O-(C 1 -C 6 )-Alkyl, R 30 R 31 N-(C 1 -C 6 )-Alkyl steht, R 36 für Wasserstoff, (C 1 -C 6 )-Alkyl, (C 2 -C 6 )-Alkenyl, (C 2 -C 6 )-Alkinyl, Aryl, Aryl-(C 1 -C 6 )-Alkyl, Heteroaryl, Heteroaryl-(C 1 -C 6 )-Alkyl, Heterocyclyl, Heterocyclyl-(C 1 -C 6 )-Alkyl, (C 3 -C 6 )- Cycloalkyl, (C 3 -C 6 )-Cycloalkyl-(C 1 -C 6 )-Alkyl, R 32 (O=)C-(C 1 -C 6 )-Alkyl, R 32 O(O)C-(C 1 -C 6 )- Alkyl, R 30 R 31 N(O)C-(C 1 -C 6 )-Alkyl, R 33 S(O)m-(C 1 -C 6 )-alkyl, R 32 O-(C 1 -C 6 )-Alkyl, R 30 R 31 N- (C 1 -C 6 )-Alkyl steht und für 0, 1, 2 steht. Ganz besonders bevorzugt sind Verbindungen der allgemeinen Formel (I), worin R 1 für (3-Methylphenyl)methyl, (4-Methylphenyl)methyl, (2-Methylphenyl)methyl, (3- Trifluormethylphenyl)methyl, (4-Trifluorethylphenyl)methyl, (2-Trifluormethylphenyl)methyl, (3-Chlorphenyl)methyl, (4-Chlorphenyl)methyl, (3-Fluorphenyl)methyl, (4-Fluorphenyl)methyl, (2-Fluorphenyl)methyl, (3,4-Difluorphenyl)methyl, (3,4-Dichlorphenyl)methyl, (3-Fluor-4- chlorphenyl) methyl, (3-Chlor-4-fluorphenyl)methyl, (3,4-Dimethylphenyl)methyl, (3,5- Difluorphenyl)methyl, (3,5-Dichlorphenyl)methyl, (3-Fluor-5-chlorphenyl) methyl, (3-Chlor-5- fluorphenyl)methyl, (3,5-Dimethylphenyl)methyl, (3,5-Ditrifluormethylphenyl)methyl, (3- Fluor-5-trifluormethylphenyl) methyl, (3-Trifluormethyl-5-fluorphenyl)methyl, (3-Chlor-5- trifluormethylphenyl) methyl, (3-Trifluormethyl-5-Chlorphenyl)methyl steht, R 2 für eine der oben genannten Gruppen G-1 und G-2 steht, wobei X für die Gruppierung O-R 36 und N(R 15 )R 35 in den Gruppen G-1 und G-2 steht und die unten beschriebene Bedeutung hat und wobei ein Pfeil für eine Bindung zum Pyrrolidinonring in der allgemeinen Formel (I) steht, aus G-1 R 7 für Wasserstoff steht, R 3 , R 4 unabhängig voneinander für Wasserstoff, Methyl, Ethyl, 1-Methylethy-1-yl, Difluormethyl stehen, R 5 , R 6 unabhängig voneinander für Wasserstoff, Methyl, Ethyl, 1-Methyleth-1-yl, 1,1-Dimethyleth-1- yl, Phenyl, 4-Fluorphenyl, 4-Chlorphenyl, Hydroxy, Methoxy, Trifluormethyloxy stehen, R 13 , R 14 unabhängig voneinander für Wasserstoff, Methyl, Ethyl, 1-Methyleth-1-yl, 1,1-Dimethyleth-1- yl stehen und, X für OH, (1-methyl-1H-1,2,4-triazol-5-yl)amino, (1-ethyl-1H-1,2,4-triazol-5-yl)amino, (1- methyl-1H-tetrazol-5-yl)amino, (1-ethyl-1H-tetrazol-5-yl)amino, [1-carboxy-2- methylbutyl]amino, [(1S,2S)-1-carboxy-2-methylbutyl]amino, [(1R,2S)-1-carboxy-2- methylbutyl]amino, [(1R,2R)-1-carboxy-2-methylbutyl]amino, [(1S,2R)-1-carboxy-2- methylbutyl]amino, (5-methoxy-2,5-dioxopentyl)amino, 2-(4-fluorphenoxy)ethoxy; methoxy; 2- methylsulfonylethoxy; 2-methylsulfanylethoxy; methanesulfonamido; 2-carboxypyrrolidin-1-yl, 2-methoxyethoxy, cyclopentyloxy, 2,2-dimethylpropoxy, ethoxy, cyclopropylmethoxy, prop-2- en-1-yloxy, 2-phenylsulfanylethoxy, prop-2-yn-1-yloxy, cyclobutyloxy, isopropyloxy, but-3- enoxy, 2-phenoxyethoxy, pentan-2-yloxy, 2-(4-chlorphenyl)sulfinylethoxy, butan-2-yloxy, 2-(4- methoxyphenoxy)ethoxy, 2-(benzenesulfonyl)ethoxy, 2-(4-chlorphenoxy)ethoxy, 2-(4- methylphenoxy)ethoxy, 3-methylbutan-2-yloxy, [3-(1H-imidazol-4-yl)-1-methoxy-1- oxopropan-2-yl]amino, [(2R)-3-(1H-imidazol-4-yl)-1-methoxy-1-oxopropan-2-yl]amino, [(2S)- 3-(1H-imidazol-4-yl)-1-methoxy-1-oxopropan-2-yl]amino, 2-[(4-chlorphenyl)thio]ethoxy, [1- carboxy-2-phenylethyl]amino, [(1R)-1-carboxy-2-phenylethyl]amino, [(1S)-1-carboxy-2- phenylethyl]amino, [1-carboxy-2-(4-hydroxyphenyl)ethyl]amino, [(1R)-1-carboxy-2-(4- hydroxyphenyl)ethyl]amino, [(1S)-1-carboxy-2-(4-hydroxyphenyl)ethyl]amino, [1-carboxy-2- (4-methoxyphenyl)ethyl]amino, [(1R)-1-carboxy-2-(4-methoxyphenyl)ethyl]amino, [(1S)-1- carboxy-2-(4-methoxyphenyl)ethyl]amino, 2-[(4-methoxyphenyl)thio]ethoxy, 2-[(4- methylphenyl)thio]ethoxy, [1-carboxy-3-methylbutyl]amino, [(1R)-1-carboxy-3- methylbutyl]amino, [(1S)-1-carboxy-3-methylbutyl]amino, (4-methyl-1,2,5-oxadiazol-3- yl)amino, 2-(4-methylphenyl)sulfinylethoxy, [1-(methoxycarbonyl)cyclopropyl]amino, 2- hydroxyethylamino, [3-(1H-imidazol-4-yl)-1-methoxy-1-oxopropan-2-yl]amino, [(2S)-3-(1H- imidazol-4-yl)-1-methoxy-1-oxopropan-2-yl]amino, [(2R)-3-(1H-imidazol-4-yl)-1-methoxy-1- oxopropan-2-yl]amino, [1-carboxy-2-methoxyethyl]amino, [(1R)-1-carboxy-2- methoxyethyl]amino, [(1S)-1-carboxy-2-methoxyethyl]amino, [1-carboxy-2- methylthioethyl]amino, [(1R)-1-carboxy-2-methylthioethyl]amino, [(1S)-1-carboxy-2- methylthioethyl]amino, [1-carboxyethyl]amino, [(1R)-1-carboxyethyl]amino, [(1S)-1- carboxyethyl]amino, [1-carboxy-2-methylpropyl]amino, [(1R)-1-carboxy-2- methylpropyl]amino, [(1S)-1-carboxy-2-methylpropyl]amino, trifluormethylsulfonylamino, (2- methoxy-2-oxoethyl)-methylamino, 2-(4-methoxyphenyl)sulfonylethoxy, benzylamino, 2- methylpropylamino, amino, 2,2-dimethylhydrazino, hydrazino, prop-2-en-1-ylamino, 2-(4- methoxyphenyl)sulfinylethoxy, 2-phenylethylamino, (6-chlorpyridin-3-yl)methyl-methylamino, (4-methoxy-4-oxobutan-2-yl)amino, [(2S)-4-methoxy-4-oxobutan-2-yl)]amino, [(2R)-4- methoxy-4-oxobutan-2-yl)]amino, [2-isopropyl-5-methylcyclohexyl]oxy, [(1S,2R,5S)-2- isopropyl-5-methylcyclohexyl]oxy, [(1S,2R,5R)-2-isopropyl-5-methylcyclohexyl]oxy, [(1R,2R,5S)-2-isopropyl-5-methylcyclohexyl]oxy, [(1R,2R,5R)-2-isopropyl-5- methylcyclohexyl]oxy, [(1S,2S,5S)-2-isopropyl-5-methylcyclohexyl]oxy, [(1S,2S,5R)-2- isopropyl-5-methylcyclohexyl]oxy, [(1R,2S,5S)-2-isopropyl-5-methylcyclohexyl]oxy, [(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl]oxy, 1,2,3,4-tetrahydronaphthalen-1-ylamino, [1- carboxy-2-(1H-indol-3-yl)ethyl]amino, [(1S)-1-carboxy-2-(1H-indol-3-yl)ethyl]amino, [(1R)-1- carboxy-2-(1H-indol-3-yl)ethyl]amino, pyrrolidin-1-yl, ethylsulfonylamino, diethylamino, difluormethylsulfonylamino, isopropylsulfonylamino, pyridin-2-ylmethylamino, chinolin-5- ylmethylamino, 2-(methoxycarbonyl)anilino, 2-(3,4-dichlorphenyl)ethylamino, 2,2,2, trifluorethylsulfonylamino, dimethylsulfamoylamino, (3-methoxy-3-oxopropyl)amino, (1-ethyl- 1H-pyrazol-3-yl)methylamino, cyclopropylsulfonylamino, tert-butoxy, 2,2,2-trifluorethylamino, 2-methoxyethylamino, ethoxyethylamino, prop-2-yn-1-ylamino, (2-ethylphenyl)methylamino, (1-ethyl-3-methyl-1H-pyrazol-4-yl)methylamino, 3-methylbutylamino, 2-(2- bromphenyl)ethylamino, ethylamino, 2-(3,5-dimethoxyphenyl)ethylamino, N-methylanilino, methylsulfonylazanidyl, (6-chlorpyridin-3-yl)methylamino, 2-(2,4-difluorphenyl)ethylamino, methylamino, [2,6-dimethylindan-1-yl]amino, [(1R,2S)-2,6-dimethylindan-1-yl]amino, [(1R,2R)-2,6-dimethylindan-1-yl]amino, [(1S,2S)-2,6-dimethylindan-1-yl]amino, [(1S,2R)-2,6- dimethylindan-1-yl]amino, 2-(1,3-benzodioxol-5-yl)ethylamino, butan-2-ylamino, 2-(1H-indol- 3-yl)ethylamino, propylamino, 2-(2,6-difluorphenyl)ethylamino, 2-(3-methylphenyl)ethylamino, 2-[3-(trifluormethoxy)phenyl]ethylamino, indan-1-ylamino, chinolin-6-ylmethylamino, [1-tert- butoxy-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino, [(2S)-1-tert-butoxy-3-(4- hydroxyphenyl)-1-oxopropan-2-yl]amino, [(2R)-1-tert-butoxy-3-(4-hydroxyphenyl)-1- oxopropan-2-yl]amino, [1-methoxy-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino, [(2S)-1- methoxy-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino, [(2R)-1-methoxy-3-(4- hydroxyphenyl)-1-oxopropan-2-yl]amino, [1-tert-butoxy-3-phenyl-1-oxopropan-2-yl]amino, [(2S)-1-tert-butoxy-3-phenyl-1-oxopropan-2-yl]amino, [(2R)-1-tert-butoxy-3-phenyl-1- oxopropan-2-yl]amino, [1-methoxy-3-phenyl-1-oxopropan-2-yl]amino, [(2S)-1-methoxy-3- phenyl-1-oxopropan-2-yl]amino, [(2R)-1-methoxy-3-(4-hydroxyphenyl)-1-oxopropan-2- yl]amino, 2-(4-tert-butylphenyl)ethylamino, cyclopropylamino, isopropylamino, 2- (ethoxycarbonyl)piperidin-1-yl, (1-n-propyl-1H-1,2,4-triazol-5-yl)amino, 2-(2- fluorphenyl)ethylamino, (2-methoxy-2-oxoethyl)-methylamino, 2-(ethoxycarbonyl)piperidin-1- yl, benzhydrylamino, dimethylsulfamoylamino, N-propylanilino, cyclobutylamino, cyclohexylmethylamino, N-ethylanilino, (2-methoxy-2-oxoethyl)-methylamino, 2- (ethoxycarbonyl)piperidin-1-yl, 3-(diethylamino)propylamino, (2,4-difluorphenyl)methylamino, 2-(5-hydroxy-1H-indol-3-yl)ethylamino, anilino, cyclopentylamino, cyclohexylamino, 2-[3- (trifluormethyl)phenyl]ethylamino, 2-(diethylamino)ethylamino, isochinolin-5-ylmethylamino, carboxymethyl(methyl)amino, 2-(4-fluorphenyl)ethylamino, 2-(5-methoxy-1H-indol-3- yl)ethylamino, carboxymethyl(ethyl)amino, 2-[4-(trifluormethoxy)phenyl]ethylamino, 2-(3- bromphenyl)ethylamino, 2-(2,5-dichlorphenyl)ethylamino, 2-thiophen-2-ylethylamino, 2-(2- methoxyphenyl)ethylamino, 2-(3,4-dimethoxyphenyl)ethylamino, (4-methoxy-4- oxobutyl)amino, 2-(4-chlorphenyl)ethylamino, 2-pyridin-3-ylethylamino, 2-[3-chlor-5- (trifluormethyl)pyridin-2-yl]ethylamino, cyclopentylsulfonylamino, 2-(4- methoxyphenyl)ethylamino, 2-(3-methoxyphenyl)ethylamino, 2-(2,3-dichlorphenyl)ethylamino, 2-[3,5-bis(trifluormethyl)phenyl]ethylamino, 2-(4-methylphenyl)ethylamino, 2-(3- chlorphenyl)ethylamino, 2-(2-chlorphenyl)ethylamino, 2-pyridin-2-ylethylamino, 2-(2,4- dichlorphenyl)ethylamino, 2-(3-fluorphenyl)ethylamino, 2,2-difluorethylamino, 1,3-dimethoxy- 1,3-dioxopropan-2-yl, 5-hydroxy-1,3-dimethyl-1H-pyrazol-4-yl, 3,3-dimethyl-2,6- dioxocyclohexyl, 4,4-dimethyl-2,6-dioxocyclohexyl, 4-methyl-2,6-dioxocyclohexyl, 2,5- dioxocyclopentyl, dicyanomethyl, 2,4-dioxo-3-bicyclo[3.2.1]octanyl, 3,3,5,5-tetramethyl-2,4,6- trioxocyclohexyl, 2,6-dioxocyclohexyl, 2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-yl, 5-hydroxy-1- methyl-1H-pyrazol-4-yl, 1-cyano-2-methoxy-2-oxoethyl, 1-methoxy-1,3-dioxobutan-2-yl, 2,4- dioxo-3-bicyclo[3.2.1]oct-6-enyl, phenylsulfonyl, ethoxyethoxy, methoxyethoxyethoxy, hydroxyethoxy, hydroxyethoxyethoxy, hydroxyethoxyethoxyethoxy, cyclopropylmethoxy, cyclobutylmethoxy, cyclopentylmethoxy, cyclohexylmethoxy, cyclopropylmethylamino, cyclobutylmethylamino, cyclopentylmethylamino, cyclohexylmethylamino, oxetan-3-yloxy, oxetan-3-ylamino, tetrahydrofuran-2-yloxy, tetrahydrofuran-3-yloxy, tetrahydrofuran-2- ylmethoxy, tetrahydrofuran-3-ylmethoxy, tetrahydrofuran-2-ylamino, tetrahydrofuran-3- ylamino, tetrahydrofuran-2-ylmethylamino, tetrahydrofuran-3-ylmethylamino, benzyloxy, 4- fluorbenzyloxy, 4-chlorbenzyloxy, 3-fluorbenzyloxy, 3-chlorbenzyloxy, 2-fluorbenzyloxy, 2- chlorbenzyloxy, 4-fluorbenzylamino, 4-chlorbenzylamino, 3-fluorbenzylamino, 3- chlorbenzylamino, 2-fluorbenzylamino, 2-chlorbenzylamino, pyridin-3-ylmethylamino, pyridin- 4-ylmethylamino, 4-chlor-pyridin-2-ylmethylamino, 4-chlor-pyridin-3-ylmethylamino, 4- trifluormethyl-pyridin-3-ylmethylamino, pyridin-2-ylmethoxy, pyridin-3-ylmethoxy, pyridin-4- ylmethoxy, 4-chlor-pyridin-2-ylmethoxy, 4-chlor-pyridin-3-ylmethoxy, cyanomethylamino, cyanomethoxy, cyanoethoxy, hydroxycarbonylmethylamino, hydroxycarbonylmethoxy, hydroxycarbonylethoxy, hydroxycarbonylethylamino, methoxycarbonylmethylamino, ethoxycarbonylmethylamino, azetidin-1-yl-amino, pyrrolidin-1-ylamino, piperidin,-1-ylamino, ethylthioethoxy, 1,2,4-thiadiazol-5-ylamino, 5-(difluormethyl)-1,3,4-thiadiazol-2-ylamino, 5- tert-butyl-1,2-oxazol-3-ylamino, 4-(trifluormethyl)pyridin-2-ylamino, 5-chlor-4- (trifluormethyl)pyridin-2-ylamino, (pyridin-4-ylmethoxy)amino, hydroxyamino, methoxyamino, ethoxyamino, benzyloxyamino, methyl(methoxy)amino, methoxycarbonylmethoxyamino, ethoxycarbonylmethoxyamino, methoxycarbonylethoxyamino, ethoxycarbonylethoxyamino, hydroxycarbonylmethoxyamino, hydroxycarbonylethoxyamino, benzyloxycarbonylmethoxyamino, benzyloxycarbonylmethoxyamino, (1,1-dimethyleth-1- yl)oxycarbonylmethoxyamino, (1,1-dimethyleth-1-yl)oxycarbonylmethoxyamino steht. Im Speziellen bevorzugt sind folgende Verbindungen der allgemeinen Formel (I): 4-[2-[2-[1-[(4-Methylphenyl)methyl]-5-oxopyrrolidin-2-yl]ace tyl]oxyethoxy]benzoesäure, 2-(4- Formylphenoxy)ethyl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, (2R)-2-[[2-[1-[(4- Methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl]amino]-4-me thylsulfanylbuttersäure, 2-(4- ethylphenoxy)ethyl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, 2-(4- methylphenoxy)ethyl 2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetat, N-Benzyl-2-[1-[(4- methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetamid, Butan-2-yl-2-[1-[(4-methylphenyl)methyl]-5- oxopyrrolidin-2-yl]acetat, (2S)-3-(1H-Indol-3-yl)-2-[[2-[1-[(4-methylphenyl)methyl]-5-o xopyrrolidin-2- yl]acetyl]amino]propionsäure, N-Butan-2-yl-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2 - yl]acetamid, (2R)-4-Methyl-2-[[2-[(2R)-1-[(4-methylphenyl)methyl]-5-oxopy rrolidin-2- yl]acetyl]amino]pentancarbonsäure, (2S)-2-[[2-[1-[(4-Methylphenyl)methyl]-5-oxopyrrolidin-2- yl]acetyl]amino]-3-phenylpropionsäure, (2R)-1-[2-[1-[(4-Methylphenyl)methyl]-5-oxopyrrolidin-2- yl]acetyl]pyrrolidin-2-carbonsäure, (2S)-2-[[2-[(2S)-1-[(4-Methylphenyl)methyl]-5-oxopyrrolidin- 2- yl]acetyl]amino]-3-phenylpropionsäure, Methyl 2-[[2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2- yl]acetyl]amino]benzoat, N-Cyclopropyl-2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin- 2-yl]acetamid, N-(Isochinolin-5-ylmethyl)-2-[1-[(4-methylphenyl)methyl]-5-o xopyrrolidin-2-yl]acetamid, N-[2-(2- Bromphenyl)ethyl]-2-[1-[(4-methylphenyl)methyl]-5-oxopyrroli din-2-yl]acetamid, (2R)-3-(1H-indol-3- yl)-2-[[2-[1-[(4-methylphenyl)methyl]-5-oxopyrrolidin-2-yl]a cetyl]amino]propionsäure, N-[2-(1H- indol-3-yl)ethyl]-2-[1-[(4-methylphenyl)methyl]-5-oxopyrroli din-2-yl]acetamid, 2-[1-[(4- Methylphenyl)methyl]-5-oxopyrrolidin-2-yl]-N-(quinolin-6-ylm ethyl)acetamid, N-[2-(5-hydroxy-1H- indol-3-yl)ethyl]-2-[1-[(4-methylphenyl)methyl]-5-oxopyrroli din-2-yl]acetamid, N-[(1-ethyl-1H- pyrazol-3-yl)methyl]-2-[1-[(4-methylphenyl)methyl]-5-oxopyrr olidin-2-yl]acetamid, N-[2- (Diethylamino)ethyl]-2-[1-[(4-methylphenyl)methyl]-5-oxopyrr olidin-2-yl]acetamid, (2S,3S)-3-Methyl- 2-[[2-[(2S)-1-[(3-methylphenyl)methyl]-5-oxopyrrolidin-2-yl] acetyl]amino]pentancarbonsäure, 2-[1-[(4- Methylphenyl)methyl]-5-oxopyrrolidin-2-yl]propionsäure, Methyl (2S)-3-(1H-imidazol-4-yl)-2-[[2- [(2R)-1-[(4-Methylphenyl)methyl]-5-oxopyrrolidin-2-yl]acetyl ]amino]propionat, 2-[1-[(4- fluorphenyl)methyl]-5-oxo-3-phenylpyrrolidin-2-yl]essigsäur e, 2-[1-[(3-Fluorphenyl)methyl]-5-oxo-3- phenylpyrrolidin-2-yl]essigsäure, Methyl-2-[1-[(3,4-difluorphenyl)methyl]-5-oxopyrrolidin-2- yl]propionat, N-[2-[3-Chlor-5-(trifluormethyl)pyridin-2-yl]ethyl]-2-[1-[(4 -methylphenyl)methyl]-5- oxopyrrolidin-2-yl]acetamid. Die oben aufgeführten allgemeinen oder in Vorzugsbereichen aufgeführten Restedefinitionen gelten sowohl für die Endprodukte der Formel (I) als auch entsprechend für die jeweils zur Herstellung benötigten Ausgangs- oder Zwischenprodukte. Diese Restedefinitionen können untereinander, also auch zwischen den angegebenen bevorzugten Bereichen, beliebig kombiniert werden. Vor allem aus den Gründen der erhöhten Stresstoleranz und/oder besseren Herstellbarkeit sind erfindungsgemäße Verbindungen der genannten Formel (I) oder deren Salze bzw. deren erfindungsgemäße Verwendung von besonderem Interesse, worin einzelne Reste eine der bereits genannten oder im folgenden genannten bevorzugten Bedeutungen haben, oder insbesondere solche, worin eine oder mehrere der bereits genannten oder im Folgenden genannten bevorzugten Bedeutungen kombiniert auftreten. Im Hinblick auf die erfindungsgemäßen Verbindungen werden die vorstehend und weiter unten verwendeten Bezeichnungen erläutert. Diese sind dem Fachmann geläufig und haben insbesondere die im Folgenden erläuterten Bedeutungen: Sofern nicht anders definiert, gilt generell für die Bezeichnung von chemischen Gruppen, dass die Anbindung an das Gerüst bzw. den Rest des Moleküls über das zuletzt genannte Strukturelement der betreffenden chemischen Gruppe erfolgt, d.h. beispielsweise im Falle von (C 2 -C 8 )-Alkenyloxy über das Sauerstoffatom, und im Falle von Heterocyclyl-(C 1 -C 8 )-alkyl oder R 32 O(O)C-(C 1 -C 8 )-Alkyl jeweils über das C-Atom der Alkylgruppe. In einer zusammengesetzten chemischen Gruppe wie z. B. Heterocyclyl- (C 1 -C 8 )-alkyl oder R 32 O(O)C-(C 1 -C 8 )-Alkyl steht die Bezeichnung “Alkyl” daher auch für eine Alkylengruppe. Bei den funktionellen Gruppen C(=O)R 32 , C(=O)OR 32 , C(=O)NR 30 R 31 , NR 30 R 31 , OR 32 , S(O) m R 33 erfolgt die Anbindung an das Gerüst bzw. den Rest des Moleküls über das zuerst genannte Strukturelement der betreffenden chemischen Gruppe. Erfindungsgemäß steht "Alkylsulfonyl" - in Alleinstellung oder als Bestandteil einer chemischen Gruppe - für geradkettiges oder verzweigtes Alkylsulfonyl, vorzugsweise mit 1 bis 8, oder mit 1 bis 6 Kohlenstoffatomen, z.B. (aber nicht beschränkt auf) (C 1 -C 6 )-Alkylsulfonyl wie Methylsulfonyl, Ethyl- sulfonyl, Propylsulfonyl, 1-Methylethylsulfonyl, Butylsulfonyl, 1-Methylpropylsulfonyl, 2-Methyl- propylsulfonyl, 1,1-Dimethylethylsulfonyl, Pentylsulfonyl, 1-Methylbutylsulfonyl, 2-Methylbutyl- sulfonyl, 3-Methylbutylsulfonyl, 1,1-Dimethylpropylsulfonyl, 1,2-Dimethylpropylsulfonyl, 2,2-Di- methylpropylsulfonyl, 1-Ethylpropylsulfonyl, Hexylsulfonyl, 1-Methylpentylsulfonyl, 2-Methyl- pentylsulfonyl, 3-Methylpentylsulfonyl, 4-Methylpentylsulfonyl, 1,1-Dimethylbutylsulfonyl, 1,2-Di- methylbutylsulfonyl, 1,3-Dimethylbutylsulfonyl, 2,2-Dimethylbutylsulfonyl, 2,3-Dimethylbutylsulfonyl, 3,3-Dimethylbutylsulfonyl, 1-Ethylbutylsulfonyl, 2-Ethylbutylsulfonyl, 1,1,2-Trimethylpropylsulfonyl, 1,2,2-Trimethylpropylsulfonyl, 1-Ethyl-1-methylpropylsulfonyl und 1-Ethyl-2-methylpropylsulfonyl. Erfindungsgemäß steht "Heteroarylsulfonyl" für gegebenenfalls substituiertes Pyridylsulfonyl, Pyrimidinylsulfonyl, Pyrazinylsulfonyl oder gegebenenfalls substituiertes polycyclisches Heteroarylsulfonyl, hier insbesondere gegebenenfalls substituiertes Chinolinylsulfonyl, beispielsweise substituiert durch Fluor, Chlor, Brom, Iod, Cyano, Nitro, Alkyl-, Haloalkyl-, Haloalkoxy-, Amino-, Alkylamino-, Alkylcarbonylamino-, Dialkylamino- oder Alkoxygruppen. Erfindungsgemäß steht "Alkylthio" - in Alleinstellung oder als Bestandteil einer chemischen Gruppe - für geradkettiges oder verzweigtes S-Alkyl, vorzugsweise mit 1 bis 8, oder mit 1 bis 6 Kohlenstoffatomen, wie (C 1 -C 10 )-, (C 1 -C 6 )- oder (C 1 -C 4 )-Alkylthio, z.B. (aber nicht beschränkt auf) (C 1 - C 6 )-Alkylthio wie Methylthio, Ethylthio, Propylthio, 1-Methylethylthio, Butylthio, 1-Methylpropylthio, 2-Methylpropylthio, 1,1-Dimethylethylthio, Pentylthio, 1-Methylbutylthio, 2-Methylbutylthio, 3- Methylbutylthio, 1,1-Dimethylpropylthio, 1,2-Dimethylpropylthio, 2,2-Dimethylpropylthio, 1- Ethylpropylthio, Hexylthio, 1-Methylpentylthio, 2-Methylpentylthio, 3-Methylpentylthio, 4-Methyl- pentylthio, 1,1-Dimethylbutylthio, 1,2-Dimethylbutylthio, 1,3-Dimethylbutylthio, 2,2-Dimethylbutyl- thio, 2,3-Dimethylbutylthio, 3,3-Dimethylbutylthio, 1-Ethylbutylthio, 2-Ethylbutylthio, 1,1,2-Tri- methylpropylthio, 1,2,2-Trimethylpropylthio, 1-Ethyl-1-methylpropylthio und 1-Ethyl-2-methyl- propylthio. „Alkenylthio“ bedeutet erfindungsgemäß ein über ein Schwefelatom gebundenen Alkenylrest, Alkinylthio bedeutet ein über ein Schwefelatom gebundenen Alkinylrest, Cycloalkylthio bedeutet ein über ein Schwefelatom gebundenen Cycloalkylrest und Cycloalkenylthio bedeutet ein über ein Schwefelatom gebundenen Cycloalkenylrest. „Alkylsulfinyl (Alkyl-S(=O)-)“, soweit nicht an anderer Stelle anders definiert steht erfindungsgemäß für Alkylreste, die über -S(=O)- an das Gerüst gebunden sind, wie (C 1 -C 10 )-, (C 1 -C 6 )- oder (C 1 -C 4 )- Alkylsulfinyl, z. B. (aber nicht beschränkt auf) (C 1 -C 6 )-Alkylsulfinyl wie Methylsulfinyl, Ethylsulfinyl, Propylsulfinyl, 1-Methylethylsulfinyl, Butylsulfinyl, 1-Methylpropylsulfinyl, 2-Methylpropylsulfinyl, 1,1-Dimethylethylsulfinyl, Pentylsulfinyl, 1-Methylbutylsulfinyl, 2-Methylbutylsulfinyl, 3- Methylbutylsulfinyl, 1,1-Dimethylpropylsulfinyl, 1,2-Dimethylpropylsulfinyl, 2,2-Di- methylpropylsulfinyl, 1-Ethylpropylsulfinyl, Hexylsulfinyl, 1-Methylpentylsulfinyl, 2-Methylpentyl- sulfinyl, 3-Methylpentylsulfinyl, 4-Methylpentylsulfinyl, 1,1-Dimethylbutylsulfinyl, 1,2-Dimethyl- butylsulfinyl, 1,3-Dimethylbutylsulfinyl, 2,2-Dimethylbutylsulfinyl, 2,3-Dimethylbutylsulfinyl, 3,3- Dimethylbutylsulfinyl, 1-Ethylbutylsulfinyl, 2-Ethylbutylsulfinyl, 1,1,2-Trimethylpropylsulfinyl, 1,2,2- Trimethylpropylsulfinyl, 1-Ethyl-1-methylpropylsulfinyl und 1-Ethyl-2-methylpropylsulfinyl. Analog sind „Alkenylsulfinyl“ und „Alkinylsulfinyl“, erfindungsgemäß definiert als Alkenyl- bzw. Alkinylreste, die über -S(=O)- an das Gerüst gebunden sind, wie (C 2 -C 10 )-, (C 2 -C 6 )- oder (C 2 -C 4 )- Alkenylsulfinyl bzw. (C 3 -C 10 )-, (C 3 -C 6 )- oder (C 3 -C 4 )-Alkinylsulfinyl. Analog sind „Alkenylsulfonyl“ und „Alkinylsulfonyl“ erfindungsgemäß definiert als Alkenyl- bzw. Alkinylreste, die über -S(=O)2- an das Gerüst gebunden sind, wie (C 2 -C 10 )-, (C 2 -C 6 )- oder (C 2 -C 4 )- Alkenylsulfonyl bzw. (C 3 -C 10 )-, (C 3 -C 6 )- oder (C 3 -C 4 )-Alkinylsulfonyl. „Alkoxy“ bedeutet ein über ein Sauerstoffatom gebundenen Alkylrest, z. B. (aber nicht beschränkt auf) (C 1 -C 6 )-Alkoxy wie Methoxy, Ethoxy, Propoxy, 1-Methylethoxy, Butoxy, 1-Methylpropoxy, 2- Methylpropoxy, 1,1-Dimethylethoxy, Pentoxy, 1-Methylbutoxy, 2-Methylbutoxy, 3-Methylbutoxy, 1,1- Dimethylpropoxy, 1,2-Dimethylpropoxy, 2,2-Dimethylpropoxy, 1-Ethylpropoxy, Hexoxy, 1- Methylpentoxy, 2-Methylpentoxy, 3-Methylpentoxy, 4-Methylpentoxy, 1,1-Dimethylbutoxy, 1,2-Di- methylbutoxy, 1,3-Dimethylbutoxy, 2,2-Dimethylbutoxy, 2,3-Dimethylbutoxy, 3,3-Dimethylbutoxy, 1- Ethylbutoxy, 2-Ethylbutoxy, 1,1,2-Trimethylpropoxy, 1,2,2-Trimethylpropoxy, 1-Ethyl-1-methyl- propoxy und 1-Ethyl-2-methylpropoxy. Alkenyloxy bedeutet ein über ein Sauerstoffatom gebundenen Alkenylrest, Alkinyloxy bedeutet ein über ein Sauerstoffatom gebundenen Alkinylrest wie (C 2 -C 10 )-, (C 2 -C 6 )- oder (C 2 -C 4 )-Alkenoxy bzw. (C 3 -C 10 )-, (C 3 -C 6 )- oder (C 3 -C 4 )-Alkinoxy. „Cycloalkyloxy“ bedeutet ein über ein Sauerstoffatom gebundenen Cycloalkylrest und Cycloalkenyloxy bedeutet ein über ein Sauerstoffatom gebundenen Cycloalkenylrest. „Alkylcarbonyl“ (Alkyl-C(=O)-), soweit nicht an anderer Stelle anders definiert, steht erfindungsgemäß für Alkylreste, die über -C(=O)- an das Gerüst gebunden sind, wie (C 1 -C 10 )-, (C 1 -C 6 )- oder (C 1 -C 4 )- Alkylcarbonyl. Die Anzahl der C-Atome bezieht sich dabei auf den Alkylrest in der Alkylcarbonylgruppe. Analog stehen „Alkenylcarbonyl“ und „Alkinylcarbonyl“, soweit nicht an anderer Stelle anders definiert, erfindungsgemäß für Alkenyl- bzw. Alkinylreste, die über -C(=O)- an das Gerüst gebunden sind, wie (C 2 -C 10 )-, (C 2 -C 6 )- oder (C 2 -C 4 )-Alkenylcarbonyl bzw. (C 2 -C 10 )-, (C 2 -C 6 )- oder (C 2 -C 4 )- Alkinylcarbonyl. Die Anzahl der C-Atome bezieht sich dabei auf den Alkenyl- bzw. Alkinylrest in der Alkenyl- bzw. Alkinylcarbonylgruppe. „Alkoxycarbonyl (Alkyl-O-C(=O)-)“, soweit nicht an anderer Stelle anders definiert: Alkylreste, die über -O-C(=O)- an das Gerüst gebunden sind, wie (C 1 -C 10 )-, (C 1 -C 6 )- oder (C 1 -C 4 )-Alkoxycarbonyl. Die Anzahl der C-Atome bezieht sich dabei auf den Alkylrest in der Alkoxycarbonylgruppe. Analog stehen „Alkenyloxycarbonyl“ und „Alkinyloxycarbonyl“, soweit nicht an anderer Stelle anders definiert, erfindungsgemäß für Alkenyl- bzw. Alkinylreste, die über -O-C(=O)- an das Gerüst gebunden sind, wie (C 2 -C 10 )-, (C 2 -C 6 )- oder (C 2 -C 4 )-Alkenyloxycarbonyl bzw. (C 3 -C 10 )-, (C 3 -C 6 )- oder (C 3 -C 4 )- Alkinyloxycarbonyl. Die Anzahl der C-Atome bezieht sich dabei auf den Alkenyl- bzw. Alkinylrest in der Alken- bzw. Alkinyloxycarbonylgruppe. Der Begriff „Alkylcarbonyloxy“ (Alkyl-C(=O)-O-) steht erfindungsgemäß, soweit nicht an anderer Stelle anders definiert, für Alkylreste, die über eine Carbonyloxygruppe (-C(=O)-O-) mit dem Sauerstoff an das Gerüst gebunden sind, wie (C 1 -C 10 )-, (C 1 -C 6 )- oder (C 1 -C 4 )-Alkylcarbonyloxy. Die Anzahl der C- Atome bezieht sich dabei auf den Alkylrest in der Alkylcarbonyloxygruppe. Analog sind „Alkenylcarbonyloxy“ und „Alkinylcarbonyloxy“ erfindungsgemäß definiert als Alkenyl- bzw. Alkinylreste, die über (-C(=O)-O-) mit dem Sauerstoff an das Gerüst gebunden sind, wie (C 2 -C 10 )-, (C 2 -C 6 )- oder (C 2 -C 4 )-Alkenylcarbonyloxy bzw. (C 2 -C 10 )-, (C 2 -C 6 )- oder (C 2 -C 4 )-Alkinylcarbonyloxy. Die Anzahl der C-Atome bezieht sich dabei auf den Alkenyl- bzw. Alkinylrest in der Alkenyl- bzw. Alkinylcarbonyloxygruppe. In Kurzformen wie z.B. C(O)R 12 , C(O)OR 12 , OC(O)NR 10 R 11 , oder C(O)NR 10 R 11 steht die in Klammern aufgeführte Kurzform O für ein über eine Doppelbindung an das benachbarte Kohlenstoffatom gebundenes Sauerstoffatom. In Kurzformen wie z.B. OC(S)OR 12 , OC(S)SR 13 , OC(S)NR 10 R 11 , steht die in Klammern aufgeführte Kurzform S für ein über eine Doppelbindung an das benachbarte Kohlenstoffatom gebundenes Schwefelatom. Der Begriff „Aryl“ bedeutet ein gegebenenfalls substituiertes mono-, bi- oder polycyclisches aromatisches System mit vorzugsweise 6 bis 14, insbesondere 6 bis 10 Ring-C-Atomen, beispielsweise Phenyl, Naphthyl, Anthryl, Phenanthrenyl, und ähnliches, vorzugsweise Phenyl. Vom Begriff „gegebenenfalls substituiertes Aryl“ sind auch mehrcyclische Systeme, wie Tetrahydronaphtyl, Indenyl, Indanyl, Fluorenyl, Biphenylyl, umfasst, wobei die Bindungsstelle am aromatischen System ist. Von der Systematik her ist „Aryl“ in der Regel auch von dem Begriff „gegebenenfalls substituiertes Phenyl“ umfasst. Bevorzugte Aryl-Substituenten sind hier zum Beispiel Wasserstoff, Halogen, Alkyl, Cycloalkyl, Cycloalkylalkyl, Cycloalkenyl, Halocycloalkyl, Alkenyl, Alkinyl, Aryl, Arylalkyl, Arylalkenyl, Heteroaryl, Heteroarylalkyl, Heterocyclyl, Heterocyclylalkyl, Alkoxyalkyl, Alkylthio, Haloalkylthio, Haloalkyl, Alkoxy, Haloalkoxy, Cycloalkoxy, Cycloalkylalkoxy, Aryloxy, Heteroraryloxy, Alkoxyalkoxy, Alkinylalkoxy, Alkenyloxy, Bis-alkylaminoalkoxy, Tris- [alkyl]silyl, Bis-[alkyl]arylsilyl, Bis-[alkyl]alkylsilyl, Tris-[alkyl]silylalkinyl, Arylalkinyl, Heteroarylalkinyl, Alkylalkinyl, Cycloalkylalkinyl, Haloalkylalkinyl, Heterocyclyl-N-alkoxy, Nitro, Cyano, Amino, Alkylamino, Bis-alkylamino, Alkylcarbonylamino, Cycloalkylcarbonylamino, Arylcarbonylamino, Alkoxycarbonylamino, Alkoxycarbonylalkylamino, Arylalkoxycarbonylalkylamino, Hydroxycarbonyl, Alkoxycarbonyl, Aminocarbonyl, Alkylaminocarbonyl, Cycloalkylaminocarbonyl, Bis-Alkylaminocarbonyl, Heteroarylalkoxy, Arylalkoxy Ein heterocyclischer Rest (Heterocyclyl) enthält mindestens einen heterocyclischen Ring (=carbocyclischer Ring, in dem mindestens ein C-Atom durch ein Heteroatom ersetzt ist, vorzugsweise durch ein Heteroatom aus der Gruppe N, O, S, P) der gesättigt, ungesättigt, teilgesättigt oder heteroaromatisch ist und dabei unsubstituiert oder substituiert sein kann, wobei die Bindungsstelle an einem Ringatom lokalisiert ist. Ist der Heterocyclylrest oder der heterocyclische Ring gegebenenfalls substituiert, kann er mit anderen carbocyclischen oder heterocyclischen Ringen annelliert sein. Im Falle von gegebenenfalls substituiertem Heterocyclyl werden auch mehrcyclische Systeme umfasst, wie beispielsweise 8-Aza-bicyclo[3.2.1]octanyl, 8-Aza-bicyclo[2.2.2]octanyl oder 1-Aza- bicyclo[2.2.1]heptyl. Im Falle von gegebenenfalls substituiertem Heterocyclyl werden auch spirocyclische Systeme umfasst, wie beispielsweise 1-Oxa-5-aza-spiro[2.3]hexyl. Wenn nicht anders definiert, enthält der heterocyclische Ring vorzugsweise 3 bis 9 Ringatome, insbesondere 3 bis 6 Ringatome, und ein oder mehrere, vorzugsweise 1 bis 4, insbesondere 1, 2 oder 3 Heteroatome im heterocyclischen Ring, vorzugsweise aus der Gruppe N, O, und S, wobei jedoch nicht zwei Sauerstoffatome direkt benachbart sein sollen, wie beispielsweise mit einem Heteroatom aus der Gruppe N, O und S 1- oder 2- oder 3-Pyrrolidinyl, 3,4-Dihydro-2H-pyrrol-2- oder 3-yl, 2,3-Dihydro-1H-pyrrol- 1- oder 2- oder 3- oder 4- oder 5-yl; 2,5-Dihydro-1H-pyrrol-1- oder 2- oder 3-yl, 1- oder 2- oder 3- oder 4-Piperidinyl; 2,3,4,5-Tetrahydropyridin-2- oder 3- oder 4- oder 5-yl oder 6-yl; 1,2,3,6- Tetrahydropyridin-1- oder 2- oder 3- oder 4- oder 5- oder 6-yl; 1,2,3,4-Tetrahydropyridin-1- oder 2- oder 3- oder 4- oder 5- oder 6-yl; 1,4-Dihydropyridin-1- oder 2- oder 3- oder 4-yl; 2,3-Dihydropyridin- 2- oder 3- oder 4- oder 5- oder 6-yl; 2,5-Dihydropyridin-2- oder 3- oder 4- oder 5- oder 6-yl, 1- oder 2- oder 3- oder 4-Azepanyl; 2,3,4,5-Tetrahydro-1H-azepin-1- oder 2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 2,3,4,7-Tetrahydro-1H-azepin-1- oder 2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 2,3,6,7- Tetrahydro-1H-azepin-1- oder 2- oder 3- oder 4-yl; 3,4,5,6-Tetrahydro-2H-azepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 4,5-Dihydro-1H-azepin-1- oder 2- oder 3- oder 4-yl; 2,5-Dihydro-1H-azepin- 1- oder -2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 2,7-Dihydro-1H-azepin-1- oder -2- oder 3- oder 4- yl; 2,3-Dihydro-1H-azepin-1- oder -2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 3,4-Dihydro-2H-azepin- 2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 3,6-Dihydro-2H-azepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 5,6-Dihydro-2H-azepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 4,5-Dihydro-3H-azepin- 2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 1H-Azepin-1- oder -2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 2H-Azepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 3H-Azepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 4H-Azepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl, 2- oder 3-Oxolanyl (= 2- oder 3- Tetrahydrofuranyl); 2,3-Dihydrofuran-2- oder 3- oder 4- oder 5-yl; 2,5-Dihydrofuran-2- oder 3-yl, 2- oder 3- oder 4-Oxanyl (= 2- oder 3- oder 4-Tetrahydropyranyl); 3,4-Dihydro-2H-pyran-2- oder 3- oder 4- oder 5- oder 6-yl; 3,6-Dihydro-2H-pyran-2- oder 3-oder 4- oder 5- oder 6-yl; 2H-Pyran-2- oder 3- oder 4- oder 5- oder 6-yl; 4H-Pyran-2- oder 3- oder 4-yl, 2- oder 3- oder 4-Oxepanyl; 2,3,4,5- Tetrahydrooxepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 2,3,4,7-Tetrahydrooxepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 2,3,6,7-Tetrahydrooxepin-2- oder 3- oder 4-yl; 2,3-Dihydrooxepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 4,5-Dihydrooxepin-2- oder 3- oder 4-yl; 2,5-Dihydrooxepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; Oxepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 2- oder 3- Tetrahydrothiophenyl; 2,3-Dihydrothiophen-2- oder 3- oder 4- oder 5-yl; 2,5-Dihydrothiophen-2- oder 3-yl; Tetrahydro-2H-thiopyran-2- oder 3- oder 4-yl; 3,4-Dihydro-2H-thiopyran-2- oder 3- oder 4- oder 5- oder 6-yl; 3,6-Dihydro-2H-thiopyran-2- oder 3- oder 4- oder 5- oder 6-yl; 2H-Thiopyran-2- oder 3- oder 4- oder 5- oder 6-yl; 4H-Thiopyran-2- oder 3- oder 4-yl. Bevorzugte 3-Ring und 4-Ring- Heterocyclen sind beispielsweise 1- oder 2-Aziridinyl, Oxiranyl, Thiiranyl, 1- oder 2- oder 3-Azetidinyl, 2- oder 3-Oxetanyl, 2- oder 3-Thietanyl, 1,3-Dioxetan-2-yl. Weitere Beispiele für “Heterocyclyl“ sind ein partiell oder vollständig hydrierter heterocyclischer Rest mit zwei Heteroatomen aus der Gruppe N, O und S, wie beispielsweise 1- oder 2- oder 3- oder 4-Pyrazolidinyl; 4,5-Dihydro-3H-pyrazol- 3- oder 4- oder 5-yl; 4,5-Dihydro-1H-pyrazol-1- oder 3- oder 4- oder 5-yl; 2,3-Dihydro-1H-pyrazol-1- oder 2- oder 3- oder 4- oder 5-yl; 1- oder 2- oder 3- oder 4- Imidazolidinyl; 2,3-Dihydro-1H-imidazol-1- oder 2- oder 3- oder 4-yl; 2,5-Dihydro-1H-imidazol-1- oder 2- oder 4- oder 5-yl; 4,5-Dihydro-1H-imidazol-1- oder 2- oder 4- oder 5-yl; Hexahydropyridazin-1- oder 2- oder 3- oder 4-yl; 1,2,3,4-Tetrahydropyridazin-1- oder 2- oder 3- oder 4- oder 5- oder 6-yl; 1,2,3,6-Tetrahydropyridazin-1- oder 2- oder 3- oder 4- oder 5- oder 6-yl; 1,4,5,6-Tetrahydropyridazin-1- oder 3- oder 4- oder 5- oder 6-yl; 3,4,5,6-Tetrahydropyridazin-3- oder 4- oder 5-yl; 4,5-Dihydropyridazin-3- oder 4-yl; 3,4-Dihydropyridazin-3- oder 4- oder 5- oder 6-yl; 3,6-Dihydropyridazin-3- oder 4-yl; 1,6-Dihydropyriazin-1- oder 3- oder 4- oder 5- oder 6-yl; Hexahydropyrimidin-1- oder 2- oder 3- oder 4-yl; 1,4,5,6-Tetrahydropyrimidin-1- oder 2- oder 4- oder 5- oder 6-yl; 1,2,5,6-Tetrahydropyrimidin-1- oder 2- oder 4- oder 5- oder 6-yl; 1,2,3,4- Tetrahydropyrimidin-1- oder 2- oder 3- oder 4- oder 5- oder 6-yl; 1,6-Dihydropyrimidin-1- oder 2- oder 4- oder 5- oder 6-yl; 1,2-Dihydropyrimidin-1- oder 2- oder 4- oder 5- oder 6-yl; 2,5-Dihydropyrimidin- 2- oder 4- oder 5-yl; 4,5-Dihydropyrimidin- 4- oder 5- oder 6-yl; 1,4-Dihydropyrimidin-1- oder 2- oder 4- oder 5- oder 6-yl; 1- oder 2- oder 3-Piperazinyl; 1,2,3,6-Tetrahydropyrazin-1- oder 2- oder 3- oder 5- oder 6-yl; 1,2,3,4-Tetrahydropyrazin-1- oder 2- oder 3- oder 4- oder 5- oder 6-yl; 1,2-Dihydropyrazin-1- oder 2- oder 3- oder 5- oder 6-yl; 1,4-Dihydropyrazin-1- oder 2- oder 3-yl; 2,3-Dihydropyrazin-2- oder 3- oder 5- oder 6-yl; 2,5-Dihydropyrazin-2- oder 3-yl; 1,3-Dioxolan-2- oder 4- oder 5-yl; 1,3-Dioxol-2- oder 4-yl; 1,3-Dioxan-2- oder 4- oder 5-yl; 4H-1,3-Dioxin-2- oder 4- oder 5- oder 6-yl; 1,4-Dioxan-2- oder 3- oder 5- oder 6-yl; 2,3-Dihydro-1,4-dioxin-2- oder 3- oder 5- oder 6-yl; 1,4-Dioxin-2- oder 3-yl; 1,2-Dithiolan-3- oder 4-yl; 3H-1,2-Dithiol-3- oder 4- oder 5-yl; 1,3-Dithiolan-2- oder 4-yl; 1,3-Dithiol- 2- oder 4-yl; 1,2-Dithian-3- oder 4-yl; 3,4-Dihydro-1,2-dithiin-3- oder 4- oder 5- oder 6-yl; 3,6-Dihydro- 1,2-dithiin-3- oder 4-yl; 1,2-Dithiin-3- oder 4-yl; 1,3-Dithian-2- oder 4- oder 5-yl; 4H-1,3-Dithiin-2- oder 4- oder 5- oder 6-yl; Isoxazolidin-2- oder 3- oder 4- oder 5-yl; 2,3-Dihydroisoxazol-2- oder 3- oder 4- oder 5-yl; 2,5-Dihydroisoxazol-2- oder 3- oder 4- oder 5-yl; 4,5-Dihydroisoxazol-3- oder 4- oder 5-yl; 1,3-Oxazolidin-2- oder 3- oder 4- oder 5-yl; 2,3-Dihydro-1,3-oxazol-2- oder 3- oder 4- oder 5-yl; 2,5- Dihydro-1,3-oxazol-2- oder 4- oder 5-yl; 4,5-Dihydro-1,3-oxazol-2- oder 4- oder 5-yl; 1,2-Oxazinan-2- oder 3- oder 4- oder 5- oder 6-yl; 3,4-Dihydro-2H-1,2-oxazin-2- oder 3- oder 4- oder 5- oder 6-yl; 3,6- Dihydro-2H-1,2-oxazin-2- oder 3- oder 4- oder 5- oder 6-yl; 5,6-Dihydro-2H-1,2-oxazin-2- oder 3- oder 4- oder 5- oder 6-yl; 5,6-Dihydro-4H-1,2-oxazin-3- oder 4- oder 5- oder 6-yl; 2H-1,2-Oxazin-2- oder 3- oder 4- oder 5- oder 6-yl; 6H-1,2-Oxazin-3- oder 4- oder 5- oder 6-yl; 4H-1,2-Oxazin-3- oder 4- oder 5- oder 6-yl; 1,3-Oxazinan-2- oder 3- oder 4- oder 5- oder 6-yl; 3,4-Dihydro-2H-1,3-oxazin-2- oder 3- oder 4- oder 5- oder 6-yl; 3,6-Dihydro-2H-1,3-oxazin-2- oder 3- oder 4- oder 5- oder 6-yl; 5,6-Dihydro-2H- 1,3-oxazin-2- oder 4- oder 5- oder 6-yl; 5,6-Dihydro-4H-1,3-oxazin-2- oder 4- oder 5- oder 6-yl; 2H- 1,3-Oxazin-2- oder 4- oder 5- oder 6-yl; 6H-1,3-Oxazin-2- oder 4- oder 5- oder 6-yl; 4H-1,3-Oxazin-2- oder 4- oder 5- oder 6-yl; Morpholin-2- oder 3- oder 4-yl; 3,4-Dihydro-2H-1,4-oxazin-2- oder 3- oder 4- oder 5- oder 6-yl; 3,6-Dihydro-2H-1,4-oxazin-2- oder 3- oder 5- oder 6-yl; 2H-1,4-oxazin-2- oder 3- oder 5- oder 6-yl; 4H-1,4-oxazin-2- oder 3-yl; 1,2-Oxazepan-2- oder 3- oder 4- oder 5- oder 6- oder 7- yl; 2,3,4,5-Tetrahydro-1,2-oxazepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 2,3,4,7-Tetrahydro-1,2- oxazepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 2,3,6,7-Tetrahydro-1,2-oxazepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 2,5,6,7-Tetrahydro-1,2-oxazepin-2- oder 3- oder 4- oder 5- oder 6- oder 7- yl; 4,5,6,7-Tetrahydro-1,2-oxazepin-3- oder 4- oder 5- oder 6- oder 7-yl; 2,3-Dihydro-1,2-oxazepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 2,5-Dihydro-1,2-oxazepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 2,7-Dihydro-1,2-oxazepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 4,5-Dihydro-1,2- oxazepin-3- oder 4- oder 5- oder 6- oder 7-yl; 4,7-Dihydro-1,2-oxazepin-3- oder 4- oder 5- oder 6- oder 7-yl; 6,7-Dihydro-1,2-oxazepin-3- oder 4- oder 5- oder 6- oder 7-yl; 1,2-Oxazepin-3- oder 4- oder 5- oder 6- oder 7-yl; 1,3-Oxazepan-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 2,3,4,5-Tetrahydro-1,3- oxazepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 2,3,4,7-Tetrahydro-1,3-oxazepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 2,3,6,7-Tetrahydro-1,3-oxazepin-2- oder 3- oder 4- oder 5- oder 6- oder 7- yl; 2,5,6,7-Tetrahydro-1,3-oxazepin-2- oder 4- oder 5- oder 6- oder 7-yl; 4,5,6,7-Tetrahydro-1,3- oxazepin-2- oder 4- oder 5- oder 6- oder 7-yl; 2,3-Dihydro-1,3-oxazepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 2,5-Dihydro-1,3-oxazepin-2- oder 4- oder 5- oder 6- oder 7-yl; 2,7-Dihydro-1,3-oxazepin- 2- oder 4- oder 5- oder 6- oder 7-yl; 4,5-Dihydro-1,3-oxazepin-2- oder 4- oder 5- oder 6- oder 7-yl; 4,7- Dihydro-1,3-oxazepin-2- oder 4- oder 5- oder 6- oder 7-yl; 6,7-Dihydro-1,3-oxazepin-2- oder 4- oder 5- oder 6- oder 7-yl; 1,3-Oxazepin-2- oder 4- oder 5- oder 6- oder 7-yl; 1,4-Oxazepan-2- oder 3- oder 5- oder 6- oder 7-yl; 2,3,4,5-Tetrahydro-1,4-oxazepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 2,3,4,7- Tetrahydro-1,4-oxazepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 2,3,6,7-Tetrahydro-1,4-oxazepin- 2- oder 3- oder 5- oder 6- oder 7-yl; 2,5,6,7-Tetrahydro-1,4-oxazepin-2- oder 3- oder 5- oder 6- oder 7- yl; 4,5,6,7-Tetrahydro-1,4-oxazepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 2,3-Dihydro-1,4- oxazepin-2- oder 3- oder 5- oder 6- oder 7-yl; 2,5-Dihydro-1,4-oxazepin-2- oder 3- oder 5- oder 6- oder 7-yl; 2,7-Dihydro-1,4-oxazepin-2- oder 3- oder 5- oder 6- oder 7-yl; 4,5-Dihydro-1,4-oxazepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 4,7-Dihydro-1,4-oxazepin-2- oder 3- oder 4- oder 5- oder 6- oder 7- yl; 6,7-Dihydro-1,4-oxazepin-2- oder 3- oder 5- oder 6- oder 7-yl; 1,4-Oxazepin-2- oder 3- oder 5- oder 6- oder 7-yl; Isothiazolidin-2- oder 3- oder 4- oder 5-yl; 2,3-Dihydroisothiazol-2- oder 3- oder 4- oder 5- yl; 2,5-Dihydroisothiazol-2- oder 3- oder 4- oder 5-yl; 4,5-Dihydroisothiazol-3- oder 4- oder 5-yl; 1,3- Thiazolidin-2- oder 3- oder 4- oder 5-yl; 2,3-Dihydro-1,3-thiazol-2- oder 3- oder 4- oder 5-yl; 2,5- Dihydro-1,3-thiazol-2- oder 4- oder 5-yl; 4,5-Dihydro-1,3-thiazol-2- oder 4- oder 5-yl; 1,3-Thiazinan-2- oder 3- oder 4- oder 5- oder 6-yl; 3,4-Dihydro-2H-1,3-thiazin-2- oder 3- oder 4- oder 5- oder 6-yl; 3,6- Dihydro-2H-1,3-thiazin-2- oder 3- oder 4- oder 5- oder 6-yl; 5,6-Dihydro-2H-1,3-thiazin-2- oder 4- oder 5- oder 6-yl; 5,6-Dihydro-4H-1,3-thiazin-2- oder 4- oder 5- oder 6-yl; 2H-1,3-Thiazin-2- oder 4- oder 5- oder 6-yl; 6H-1,3-Thiazin-2- oder 4- oder 5- oder 6-yl; 4H-1,3-Thiazin-2- oder 4- oder 5- oder 6-yl. Weitere Beispiele für “Heterocyclyl“ sind ein partiell oder vollständig hydrierter heterocyclischer Rest mit 3 Heteroatomen aus der Gruppe N, O und S, wie beispielsweise 1,4,2-Dioxazolidin-2- oder 3- oder 5-yl; 1,4,2-Dioxazol-3- oder 5-yl; 1,4,2-Dioxazinan-2- oder -3- oder 5- oder 6-yl; 5,6-Dihydro-1,4,2- dioxazin-3- oder 5- oder 6-yl; 1,4,2-Dioxazin-3- oder 5- oder 6-yl; 1,4,2-Dioxazepan-2- oder 3- oder 5- oder 6- oder 7-yl; 6,7-Dihydro-5H-1,4,2-Dioxazepin-3- oder 5- oder 6- oder 7-yl; 2,3-Dihydro-7H-1,4,2- Dioxazepin-2- oder 3- oder 5- oder 6- oder 7-yl; 2,3-Dihydro-5H-1,4,2-Dioxazepin-2- oder 3- oder 5- oder 6- oder 7-yl; 5H-1,4,2-Dioxazepin-3- oder 5- oder 6- oder 7-yl; 7H-1,4,2-Dioxazepin-3- oder 5- oder 6- oder 7-yl. Strukturbeispiele für gegebenenfalls weiter substituierte Heterocyclen sind auch im Folgenden aufgeführt: C

? ( 4 > ( & ( 2 I f 0 • Die oben aufgeführten Heterocyclen sind bevorzugt beispielsweise durch Wasserstoff, Halogen, Alkyl, Haloalkyl, Hydroxy, Alkoxy, Cycloalkoxy, Aryloxy, Alkoxyalkyl, Alkoxyalkoxy, Cycloalkyl, Halocycloalkyl, Aryl, Arylalkyl, Heteroaryl, Heterocyclyl, Alkenyl, Alkylcarbonyl, Cycloalkylcarbonyl, Arylcarbonyl, Heteroarylcarbonyl, Alkoxycarbonyl, Hydroxycarbonyl, Cycloalkoxycarbonyl, Cycloalkylalkoxycarbonyl, Alkoxycarbonylalkyl, Arylalkoxycarbonyl, Arylalkoxycarbonylalkyl, Alkinyl, Alkinylalkyl, Alkylalkinyl, Tris-alkylsilylalkinyl, Nitro, Amino, Cyano, Haloalkoxy, Haloalkylthio, Alkylthio, Hydrothio, Hydroxyalkyl, Oxo, Heteroarylalkoxy, Arylalkoxy, Heterocyclylalkoxy, Heterocyclylalkylthio, Heterocyclyloxy, Heterocyclylthio, Heteroaryloxy, Bis- alkylamino, Alkylamino, Cycloalkylamino, Hydroxycarbonylalkylamino, Alkoxycarbonylalkylamino, Arylalkoxycarbonylalkylamino, Alkoxycarbonylalkyl(alkyl)amino, Aminocarbonyl, Alkylaminocarbonyl, Bis-alkylaminocarbonyl, Cycloalkylaminocarbonyl, Hydroxycarbonylalkylaminocarbonyl, Alkoxycarbonylalkylaminocarbonyl, Arylalkoxycarbonylalkylaminocarbonyl substituiert. Wenn ein Grundkörper "durch einen oder mehrere Reste" aus einer Aufzählung von Resten (= Gruppe) oder einer generisch definierten Gruppe von Resten substituiert ist, so schließt dies jeweils die gleichzeitige Substitution durch mehrere gleiche und/oder strukturell unterschiedliche Reste ein. Handelt es sich es sich um einen teilweise oder vollständig gesättigten Stickstoff-Heterocyclus, so kann dieser sowohl über Kohlenstoff als auch über den Stickstoff mit dem Rest des Moleküls verknüpft sein. Als Substituenten für einen substituierten heterocyclischen Rest kommen die weiter unten genannten Substituenten in Frage, zusätzlich auch Oxo und Thioxo. Die Oxogruppe als Substituent an einem Ring- C-Atom bedeutet dann beispielsweise eine Carbonylgruppe im heterocyclischen Ring. Dadurch sind vorzugsweise auch Lactone und Lactame umfasst. Die Oxogruppe kann auch an den Heteroringatomen, die in verschiedenen Oxidationsstufen existieren können, z.B. bei N und S, auftreten und bilden dann beispielsweise die divalenten Gruppen N(O), S(O) (auch kurz SO) und S(O) 2 (auch kurz SO 2 ) im heterocyclischen Ring. Im Fall von –N(O)- und –S(O)-Gruppen sind jeweils beide Enantiomere umfasst. Erfindungsgemäß steht der Ausdruck „Heteroaryl“ für heteroaromatische Verbindungen, d. h. vollständig ungesättigte aromatische heterocyclische Verbindungen, vorzugsweise für 5- bis 7-gliedrige Ringe mit 1 bis 4, vorzugsweise 1 oder 2 gleichen oder verschiedenen Heteroatomen, vorzugsweise O, S oder N. Erfindungsgemäße Heteroaryle sind beispielsweise 1H-Pyrrol-1-yl; 1H-Pyrrol-2-yl; 1H-Pyrrol- 3-yl; Furan-2-yl; Furan-3-yl; Thien-2-yl; Thien-3-yl, 1H-Imidazol-1-yl; 1H-Imidazol-2-yl; 1H-Imidazol- 4-yl; 1H-Imidazol-5-yl; 1H-Pyrazol-1-yl; 1H-Pyrazol-3-yl; 1H-Pyrazol-4-yl; 1H-Pyrazol-5-yl, 1H-1,2,3- Triazol-1-yl, 1H-1,2,3-Triazol-4-yl, 1H-1,2,3-Triazol-5-yl, 2H-1,2,3-Triazol-2-yl, 2H-1,2,3-Triazol-4-yl, 1H-1,2,4-Triazol-1-yl, 1H-1,2,4-Triazol-3-yl, 4H-1,2,4-Triazol-4-yl, 1,2,4-Oxadiazol-3-yl, 1,2,4- Oxadiazol-5-yl, 1,3,4-Oxadiazol-2-yl, 1,2,3-Oxadiazol-4-yl, 1,2,3-Oxadiazol-5-yl, 1,2,5-Oxadiazol-3-yl, Azepinyl, Pyridin-2-yl, Pyridin-3-yl, Pyridin-4-yl, Pyrazin-2-yl, Pyrazin-3-yl, Pyrimidin-2-yl, Pyrimidin-4-yl, Pyrimidin-5-yl, Pyridazin-3-yl, Pyridazin-4-yl, 1,3,5-Triazin-2-yl, 1,2,4-Triazin-3-yl, 1,2,4-Triazin-5-yl, 1,2,4-Triazin-6-yl, 1,2,3-Triazin-4-yl, 1,2,3-Triazin-5-yl, 1,2,4-, 1,3,2-, 1,3,6- und 1,2,6-Oxazinyl, Isoxazol-3-yl, Isoxazol-4-yl, Isoxazol-5-yl, 1,3-Oxazol-2-yl, 1,3-Oxazol-4-yl, 1,3- Oxazol-5-yl, Isothiazol-3-yl, Isothiazol-4-yl, Isothiazol-5-yl, 1,3-Thiazol-2-yl, 1,3-Thiazol-4-yl, 1,3- Thiazol-5-yl, Oxepinyl, Thiepinyl, 1,2,4-Triazolonyl und 1,2,4-Diazepinyl, 2H-1,2,3,4-Tetrazol-5-yl, 1H-1,2,3,4-Tetrazol-5-yl, 1,2,3,4-Oxatriazol-5-yl, 1,2,3,4-Thiatriazol-5-yl, 1,2,3,5-Oxatriazol-4-yl, 1,2,3,5-Thiatriazol-4-yl. Die erfindungsgemäßen Heteroarylgruppen können ferner mit einem oder mehreren, gleichen oder verschiedenen Resten substituiert sein. Sind zwei benachbarte Kohlenstoffatome Bestandteil eines weiteren aromatischen Rings, so handelt es sich um annellierte heteroaromatische Systeme, wie benzokondensierte oder mehrfach annellierte Heteroaromaten. Bevorzugt sind beispielsweise Chinoline (z. B. Chinolin-2-yl, Chinolin-3-yl, Chinolin-4-yl, Chinolin-5- yl, Chinolin-6-yl, Chinolin-7-yl, Chinolin-8-yl); Isochinoline (z. B. Isochinolin-1-yl, Isochinolin-3-yl, Isochinolin-4-yl, Isochinolin-5-yl, Isochinolin-6-yl, Isochinolin-7-yl, Isochinolin-8-yl); Chinoxalin; Chinazolin; Cinnolin; 1,5-Naphthyridin; 1,6-Naphthyridin; 1,7-Naphthyridin; 1,8-Naphthyridin; 2,6- Naphthyridin; 2,7-Naphthyridin; Phthalazin; Pyridopyrazine; Pyridopyrimidine; Pyridopyridazine; Pteridine; Pyrimidopyrimidine. Beispiele für Heteroaryl sind auch 5- oder 6-gliedrige benzokondensierte Ringe aus der Gruppe 1H-Indol-1-yl, 1H-Indol-2-yl, 1H-Indol-3-yl, 1H-Indol-4-yl, 1H-Indol-5-yl, 1H- Indol-6-yl, 1H-Indol-7-yl, 1-Benzofuran-2-yl, 1-Benzofuran-3-yl, 1-Benzofuran-4-yl, 1-Benzofuran-5- yl, 1-Benzofuran-6-yl, 1-Benzofuran-7-yl, 1-Benzothiophen-2-yl, 1-Benzothiophen-3-yl, 1- Benzothiophen-4-yl, 1-Benzothiophen-5-yl, 1-Benzothiophen-6-yl, 1-Benzothiophen-7-yl, 1H-Indazol- 1-yl, 1H-Indazol-3-yl, 1H-Indazol-4-yl, 1H-Indazol-5-yl, 1H-Indazol-6-yl, 1H-Indazol-7-yl, 2H-Indazol- 2-yl, 2H-Indazol-3-yl, 2H-Indazol-4-yl, 2H-Indazol-5-yl, 2H-Indazol-6-yl, 2H-Indazol-7-yl, 2H- Isoindol-2-yl, 2H-Isoindol-1-yl, 2H-Isoindol-3-yl, 2H-Isoindol-4-yl, 2H-Isoindol-5-yl, 2H-Isoindol-6-yl; 2H-Isoindol-7-yl, 1H-Benzimidazol-1-yl, 1H-Benzimidazol-2-yl, 1H-Benzimidazol-4-yl, 1H- Benzimidazol-5-yl, 1H-Benzimidazol-6-yl, 1H-Benzimidazol-7-yl, 1,3-Benzoxazol-2-yl, 1,3- Benzoxazol-4-yl, 1,3-Benzoxazol-5-yl, 1,3-Benzoxazol-6-yl, 1,3-Benzoxazol-7-yl, 1,3-Benzthiazol-2-yl, 1,3-Benzthiazol-4-yl, 1,3-Benzthiazol-5-yl, 1,3-Benzthiazol-6-yl, 1,3-Benzthiazol-7-yl, 1,2- Benzisoxazol-3-yl, 1,2-Benzisoxazol-4-yl, 1,2-Benzisoxazol-5-yl, 1,2-Benzisoxazol-6-yl, 1,2- Benzisoxazol-7-yl, 1,2-Benzisothiazol-3-yl, 1,2-Benzisothiazol-4-yl, 1,2-Benzisothiazol-5-yl, 1,2- Benzisothiazol-6-yl, 1,2-Benzisothiazol-7-yl. Die Bezeichnung "Halogen" bedeutet beispielsweise Fluor, Chlor, Brom oder Iod. Wird die Bezeichnung für einen Rest verwendet, dann bedeutet "Halogen" beispielsweise ein Fluor-, Chlor-, Brom- oder Iodatom. Erfindungsgemäß bedeutet „Alkyl“ einen geradkettigen oder verzweigten offenkettigen, gesättigten Kohlenwasserstoffrest, der gegebenenfalls ein- oder mehrfach substituiert ist und im letzteren Falle als „substituiertes Alkyl“ bezeichnet wird. Bevorzugte Substituenten sind Halogenatome, Alkoxy-, Haloalkoxy-, Cyano-, Alkylthio, Haloalkylthio-, Amino- oder Nitrogruppen, besonders bevorzugt sind Methoxy, Methyl, Fluoralkyl, Cyano, Nitro, Fluor, Chlor, Brom oder Iod. Die Vorsilbe „Bis“ schließt auch die Kombination unterschiedlicher Alkylreste ein, z. B. Methyl(Ethyl) oder Ethyl(Methyl). „Haloalkyl“, „-alkenyl“ und „-alkinyl“ bedeuten durch gleiche oder verschiedene Halogenatome, teilweise oder vollständig substituiertes Alkyl, Alkenyl bzw. Alkinyl, z.B. Monohaloalkyl (= Monohalogenalkyl) wie z. B. CH2CH2Cl, CH2CH2Br, CHClCH 3 , CH2Cl, CH2F; Perhaloalkyl wie z. B. CCl3, CClF2, CFCl2,CF2CClF2, CF2CClFCF3; Polyhaloalkyl wie z. B. CH2CHFCl, CF2CClFH, CF2CBrFH, CH2CF3; Der Begriff Perhaloalkyl umfasst dabei auch den Begriff Perfluoralkyl. „Teilfluoriertes Alkyl“ bedeutet einen geradkettigen oder verzweigten, gesättigten Kohlenwasserstoff, der einfach oder mehrfach durch Fluor substituiert ist, wobei sich die entsprechenden Fluoratome als Substituenten an einem oder mehreren verschiedenen Kohlenstoffatomen der geradkettigen oder verzweigten Kohlenwasserstoffkette befinden können, wie z. B. CHFCH 3 , CH 2 CH 2 F, CH 2 CH 2 CF 3 , CHF2, CH2F, CHFCF2CF3 „Teilfluoriertes Haloalkyl“ bedeutet einen geradkettigen oder verzweigten, gesättigten Kohlenwasserstoff, der durch verschiedene Halogenatome mit mindestens einem Fluoratom substituiert ist, wobei alle anderen gegebenenfalls vorhandenen Halogenatome ausgewählt sind aus der Gruppe Fluor, Chlor oder Brom, Iod. Die entsprechenden Halogenatome können sich dabei als Substituenten an einem oder mehreren verschiedenen Kohlenstoffatomen der geradkettigen oder verzweigten Kohlenwasserstoffkette befinden. Teilfluoriertes Haloalkyl schließt auch die vollständige Substitution der geradkettigen oder verzweigten Kette durch Halogen unter Beteiligung von mindestens einem Fluoratom ein. „Haloalkoxy“ ist z.B. OCF 3 , OCHF 2 , OCH 2 F, OCF 2 CF 3 , OCH 2 CF 3 und OCH 2 CH 2 Cl; Entsprechendes gilt für Haloalkenyl und andere durch Halogen substituierten Reste. Der hier beispielhaft genannte Ausdruck "(C 1 -C 4 )-Alkyl" bedeutet eine Kurzschreibweise für geradkettiges oder verzweigtes Alkyl mit einem bis 4 Kohlenstoffatomen entsprechend der Bereichsangabe für C-Atome, d. h. umfasst die Reste Methyl, Ethyl, 1-Propyl, 2-Propyl, 1-Butyl, 2-Butyl, 2-Methylpropyl oder tert-Butyl. Allgemeine Alkylreste mit einem größeren angegebenen Bereich von C-Atomen, z. B. "(C 1 -C 6 )-Alkyl", umfassen entsprechend auch geradkettige oder verzweigte Alkylreste mit einer größeren Zahl von C-Atomen, d. h. gemäß Beispiel auch die Alkylreste mit 5 und 6 C-Atomen. Wenn nicht speziell angegeben, sind bei den Kohlenwasserstoffresten wie Alkyl-, Alkenyl- und Alkinylresten, auch in zusammengesetzten Resten, die niederen Kohlenstoffgerüste, z.B. mit 1 bis 6 C-Atomen bzw. bei ungesättigten Gruppen mit 2 bis 6 C-Atomen, bevorzugt. Alkylreste, auch in den zusammengesetzten Resten wie Alkoxy, Haloalkyl usw., bedeuten z.B. Methyl, Ethyl, n- oder i-Propyl, n-, i-, t- oder 2-Butyl, Pentyle, Hexyle, wie n-Hexyl, i-Hexyl und 1,3-Dimethylbutyl, Heptyle, wie n-Heptyl, 1-Methylhexyl und 1,4-Dimethylpentyl; Alkenyl- und Alkinylreste haben die Bedeutung der den Alkylresten entsprechenden möglichen ungesättigten Reste, wobei mindestens eine Doppelbindung bzw. Dreifachbindung enthalten ist. Bevorzugt sind Reste mit einer Doppelbindung bzw. Dreifachbindung. Der Begriff „Alkenyl“ schließt insbesondere auch geradkettige oder verzweigte offenkettige Kohlenwasserstoffreste mit mehr als einer Doppelbindung ein, wie 1,3-Butadienyl und 1,4-Pentadienyl, aber auch Allenyl- oder Kumulenyl-reste mit einer bzw. mehreren kumulierten Doppelbindungen, wie beispielsweise Allenyl (1,2-Propadienyl), 1,2-Butadienyl und 1,2,3-Pentatrienyl. Alkenyl bedeutet z.B. Vinyl, welches ggf. durch weitere Alkylreste substituiert sein kann, z B. (aber nicht beschränkt auf) (C 2 -C 6 )-Alkenyl wie Ethenyl, 1-Propenyl, 2-Propenyl, 1-Methylethenyl, 1-Butenyl, 2-Butenyl, 3- Butenyl, 1-Methyl-1-propenyl, 2-Methyl-1-propenyl, 1-Methyl-2-propenyl, 2-Methyl-2-propenyl, 1- Pentenyl, 2-Pentenyl, 3-Pentenyl, 4-Pentenyl, 1-Methyl-1-butenyl, 2-Methyl-1-butenyl, 3-Methyl-1- butenyl, 1-Methyl-2-butenyl, 2-Methyl-2-butenyl, 3-Methyl-2-butenyl, 1-Methyl-3-butenyl, 2-Methyl-3- butenyl, 3-Methyl-3-butenyl, 1,1-Dimethyl-2-propenyl, 1,2-Dimethyl-1-propenyl, 1,2-Dimethyl-2- propenyl, 1-Ethyl-1-propenyl, 1-Ethyl-2-propenyl, 1-Hexenyl, 2-Hexenyl, 3-Hexenyl, 4-Hexenyl, 5- Hexenyl, 1-Methyl-1-pentenyl, 2-Methyl-1-pentenyl, 3-Methyl-1-pentenyl, 4-Methyl-1-pentenyl, 1- Methyl-2-pentenyl, 2-Methyl-2-pentenyl, 3-Methyl-2-pentenyl, 4-Methyl-2-pentenyl, 1-Methyl-3- pentenyl, 2-Methyl-3-pentenyl, 3-Methyl-3-pentenyl, 4-Methyl-3-pentenyl, 1-Methyl-4-pentenyl, 2- Methyl-4-pentenyl, 3-Methyl-4-pentenyl, 4-Methyl-4-pentenyl, 1,1-Dimethyl-2-butenyl, 1,1-Dimethyl- 3-butenyl, 1,2-Dimethyl-1-butenyl, 1,2-Dimethyl-2-butenyl, 1,2-Dimethyl-3-butenyl, 1,3-Dimethyl-1- butenyl, 1,3-Dimethyl-2-butenyl, 1,3-Dimethyl-3-butenyl, 2,2-Dimethyl-3-butenyl, 2,3-Dimethyl-1- butenyl, 2,3-Dimethyl-2-butenyl, 2,3-Dimethyl-3-butenyl, 3,3-Dimethyl-1-butenyl, 3,3-Dimethyl-2- butenyl, 1-Ethyl-1-butenyl, 1-Ethyl-2-butenyl, 1-Ethyl-3-butenyl, 2-Ethyl-1-butenyl, 2-Ethyl-2-butenyl, 2-Ethyl-3-butenyl, 1,1,2-Trimethyl-2-propenyl, 1-Ethyl-1-methyl-2-propenyl, 1-Ethyl-2-methyl-1- propenyl und 1-Ethyl-2-methyl-2-propenyl. Der Begriff „Alkinyl“ schließt insbesondere auch geradkettige oder verzweigte offenkettige Kohlenwasserstoffreste mit mehr als einer Dreifachbindung oder auch mit einer oder mehreren Dreifachbindungen und einer oder mehreren Doppelbindungen ein, wie beispielsweise 1,3-Butatrienyl bzw.3-Penten-1-in-1-yl. (C 2 -C 6 )-Alkinyl bedeutet z.B. Ethinyl, 1-Propinyl, 2-Propinyl, 1-Butinyl, 2- Butinyl, 3-Butinyl, 1-Methyl-2-propinyl, 1-Pentinyl, 2-Pentinyl, 3-Pentinyl, 4-Pentinyl, 1-Methyl-2- butinyl, 1-Methyl-3-butinyl, 2-Methyl-3-butinyl, 3-Methyl-1-butinyl, 1,1-Dimethyl-2-propinyl, 1-Ethyl- 2-propinyl, 1-Hexinyl, 2-Hexinyl, 3-Hexinyl, 4-Hexinyl, 5-Hexinyl, 1-Methyl-2-pentinyl, 1-Methyl-3- pentinyl, 1-Methyl-4-pentinyl, 2-Methyl-3-pentinyl, 2-Methyl-4-pentinyl, 3-Methyl-1-pentinyl, 3- Methyl-4-pentinyl, 4-Methyl-1-pentinyl, 4-Methyl-2-pentinyl, 1,1-Di-methyl-2-butinyl, 1,1-Dimethyl-3- butinyl, 1,2-Dimethyl-3-butinyl, 2,2-Dimethyl-3-butinyl, 3,3-Dimethyl-1-butinyl, 1-Ethyl-2-butinyl, 1- Ethyl-3-butinyl, 2-Ethyl-3-butinyl und 1-Ethyl-1-methyl-2-propinyl. Der Begriff „Cycloalkyl“ bedeutet ein carbocyclisches, gesättigtes Ringsystem mit vorzugsweise 3-8 Ring-C-Atomen, z.B. Cyclopropyl, Cyclobutyl, Cyclopentyl oder Cyclohexyl, das gegebenenfalls weiter substituiert ist, bevorzugt durch Wasserstoff, Alkyl, Alkoxy, Cyano, Nitro, Alkylthio, Haloalkylthio, Halogen, Alkenyl, Alkinyl, Haloalkyl, AMino, Alkylamino, Bisalkylamino, Alkocycarbonyl, Hydroxycarbonyl, Arylalkoxycarbonyl, Aminocarbonyl, Alkylaminocarbonyl, Cycloalkylaminocarbonyl. Im Falle von gegebenenfalls substituiertem Cycloalkyl werden cyclische Systeme mit Substituenten umfasst, wobei auch Substituenten mit einer Doppelbindung am Cycloalkylrest, z. B. eine Alkylidengruppe wie Methyliden, umfasst sind. Im Falle von gegebenenfalls substituiertem Cycloalkyl werden auch mehrcyclische aliphatische Systeme umfasst, wie beispielsweise Bicyclo[1.1.0]butan-1-yl, Bicyclo[1.1.0]butan-2-yl, Bicyclo[2.1.0]pentan-1-yl, Bicyclo[1.1.1]pentan-1- yl, Bicyclo[2.1.0]pentan-2-yl, Bicyclo[2.1.0]pentan-5-yl, Bicyclo[2.1.1]hexyl, Bicyclo[2.2.1]hept-2-yl, Bicyclo[2.2.2]octan-2-yl, Bicyclo[3.2.1]octan-2-yl, Bicyclo[3.2.2]nonan-2-yl, Adamantan-1-yl und Adamantan-2-yl, aber auch Systeme wie z. B.1,1'-Bi(cyclopropyl)-1-yl, 1,1'-Bi(cyclopropyl)-2-yl. Der Ausdruck "(C 3 -C 7 )-Cycloalkyl" bedeutet eine Kurzschreibweise für Cycloalkyl mit drei bis 7 Kohlenstoffatomen entsprechend der Bereichsangabe für C-Atome. Im Falle von substituiertem Cycloalkyl werden auch spirocyclische aliphatische Systeme umfasst, wie beispielsweise Spiro[2.2]pent-1-yl, Spiro[2.3]hex-1-yl, Spiro[2.3]hex-4-yl, 3-Spiro[2.3]hex-5-yl, Spiro[3.3]hept-1-yl, Spiro[3.3]hept-2-yl. „Cycloalkenyl“ bedeutet ein carbocyclisches, nicht aromatisches, partiell ungesättigtes Ringsystem mit vorzugsweise 4-8 C-Atomen, z.B.1-Cyclobutenyl, 2-Cyclobutenyl, 1-Cyclopentenyl, 2-Cyclopentenyl, 3-Cyclopentenyl, oder 1-Cyclohexenyl, 2-Cyclohexenyl, 3-Cyclohexenyl, 1,3-Cyclohexadienyl oder 1,4-Cyclohexadienyl, wobei auch Substituenten mit einer Doppelbindung am Cycloalkenylrest, z. B. eine Alkylidengruppe wie Methyliden, umfasst sind. Im Falle von gegebenenfalls substituiertem Cycloalkenyl gelten die Erläuterungen für substituiertes Cycloalkyl entsprechend. Der Begriff „Alkyliden“, z. B. auch in der Form (C 1 -C 10 )-Alkyliden, bedeutet den Rest eines geradkettigen oder verzweigten offenkettigen Kohlenwasserstoffrests, der über eine Zweifachbindung gebunden ist. Als Bindungsstelle für Alkyliden kommen naturgemäß nur Positionen am Grundkörper in Frage, an denen zwei H-Atome durch die Doppelbindung ersetzt werden können; Reste sind z. B. =CH2, =CH-CH 3 , =C(CH 3 )-CH 3 , =C(CH 3 )-C 2 H5 oder =C(C 2 H5)-C 2 H5. Cycloalkyliden bedeutet ein carbocyclischer Rest, der über eine Zweifachbindung gebunden ist. „Cycloalkylalkyloxy“ bedeutet ein über ein Sauerstoffatom gebundenen Cycloalkylalkylrest und „Arylalkyloxy“ bedeutet ein über ein Sauerstoffatom gebundenen Arylalkylrest. „Alkoxyalkyl“ steht für einen über eine Alkylgruppe gebundenen Alkoxyrest und „Alkoxyalkoxy“ bedeutet einen über ein Sauerstoffatom gebundenen Alkoxyalkylrest, z.B. (aber nicht beschränkt auf) Methoxymethoxy, Methoxyethoxy, Ethoxyethoxy, Methoxy-n-propyloxy. „Alkylthioalkyl“ steht für einen über eine Alkylgruppe gebundenen Alkylthiorest und „Alkylthioalkylthio“ bedeutet einen über ein Sauerstoffatom gebundenen Alkylthioalkylrest. „Arylalkoxyalkyl“ steht für einen über eine Alkylgruppe gebundenen Aryloxyrest und „Heteroaryloxyalkyl“ bedeutet einen über eine Alkylgruppe gebundenen Heteroaryloxyrest. „Haloalkoxyalkyl“ steht für einen gebundenen Haloalkoxyrest und „Haloalkylthioalkyl“ bedeutet einen über eine Alkylgruppe gebundenen Haloalkylthiorest. „Arylalkyl“ steht für einen über eine Alkylgruppe gebundenen Arylrest, „Heteroarylalkyl“ bedeutet einen über eine Alkylgruppe gebundenen Heteroarylrest, und „Heterocyclylalkyl“ bedeutet einen über eine Alkylgruppe gebundenen Heterocyclylrest. „Cycloalkylalkyl“ steht für einen über eine Alkylgruppe gebundenen Cycloalkylrest, z. B. (aber nicht beschränkt auf) Cyclopropylmethyl, Cyclobutylmethyl, Cyclopentylmethyl, Cyclohexylmethyl, 1- Cyclopropyleth-1-yl, 2-Cyclopropyleth-1-yl, 1-Cyclopropylprop-1-yl, 3-Cyclopropylprop-1-yl. „Arylalkenyl“ steht für einen über eine Alkenylgruppe gebundenen Arylrest, „Heteroarylalkenyl“ bedeutet einen über eine Alkenylgruppe gebundenen Heteroarylrest, und „Heterocyclylalkenyl“ bedeutet einen über eine Alkenylgruppe gebundenen Heterocyclylrest. „Arylalkinyl“ steht für einen über eine Alkinylgruppe gebundenen Arylrest, „Heteroarylalkinyl“ bedeutet einen über eine Alkinylgruppe gebundenen Heteroarylrest, und „Heterocyclylalkinyl“ bedeutet einen über eine Alkinylgruppe gebundenen Heterocyclylrest. Erfindungsgemäß steht "Haloalkylthio" - in Alleinstellung oder als Bestandteil einer chemischen Gruppe - für geradkettiges oder verzweigtes S-Halogenalkyl, vorzugsweise mit 1 bis 8, oder mit 1 bis 6 Kohlenstoffatomen, wie (C 1 -C 8 )-, (C 1 -C 6 )- oder (C 1 -C 4 )-Haloalkylthio, z.B. (aber nicht beschränkt auf) Trifluormethylthio, Pentafluorethylthio, Difluormethyl, 2,2-Difluoreth-1-ylthio, 2,2,2-Difluoreth-1- ylthio, 3,3,3-prop-1-ylthio. „Halocycloalkyl“ und „Halocycloalkenyl“ bedeuten durch gleiche oder verschiedene Halogenatome, wie z. B. F, Cl und Br, oder durch Haloalkyl, wie z. B. Trifluormethyl oder Difluormethyl teilweise oder vollständig substituiertes Cycloalkyl oder Cycloalkenyl , z.B.1-Fluorcycloprop-1-yl, 2-Fluorcycloprop- 1-yl, 2,2-Difluorcycloprop-1-yl, 1-Fluorcyclobut-1-yl, 1-Trifluormethylcycloprop-1-yl, 2- Trifluormethylcycloprop-1-yl, 1-Chlor-cycloprop-1-yl, 2-Chlorcycloprop-1-yl, 2,2-Dichlorcycloprop-1- yl, 3,3-Difluorcyclobutyl, Erfindungsgemäß steht "Trialkylsilyl" - in Alleinstellung oder als Bestandteil einer chemischen Gruppe - für geradkettiges oder verzweigtes Si-Alkyl, vorzugsweise mit 1 bis 8, oder mit 1 bis 6 Kohlenstoffatomen, wie Tri-[(C 1 -C 8 )-, (C 1 -C 6 )- oder (C 1 -C 4 )-alkyl]silyl, z.B. (aber nicht beschränkt auf) Trimethylsilyl, Triethylsilyl, Tri-(n-propyl)silyl, Tri-(iso-propyl)silyl, Tri-(n-butyl)silyl, Tri-(1- methylprop-1-yl)silyl, Tri-(2-methylprop-1-yl)silyl, Tri(1,1-Dimethyleth-1-yl)silyl, Tri(2,2- Dimethyleth-1-yl)silyl. „Trialkylsilylalkinyl“ steht für einen über eine Alkinylgruppe gebundenen Trialkylsilylrest. Wenn die Verbindungen durch Wasserstoffverschiebung Tautomere bilden können, welche strukturell formal nicht durch die Formel (I) erfasst würden, so sind diese Tautomere gleichwohl von der Definition der erfindungsgemäßen Verbindungen der Formel (I) umfasst, sofern nicht ein bestimmtes Tautomer Gegenstand der Betrachtung ist. So können beispielsweise viele Carbonylverbindungen sowohl in der Ketoform wie auch in der Enolform vorliegen, wobei beide Formen durch die Definition der Verbindung der Formel (I) umfasst werden. Die Verbindungen der allgemeinen Formel (I) können je nach Art und Verknüpfung der Substituenten als Stereoisomere vorliegen. Die durch ihre spezifische Raumform definierten möglichen Stereoisomere, wie Enantiomere, Diastereomere, Z- und E-Isomere sind alle von der Formel (I) umfasst. Sind beispielsweise eine oder mehrere Alkenylgruppen vorhanden, so können Diastereomere (Z- und E- Isomere) auftreten. Sind beispielsweise ein oder mehrere asymmetrische Kohlenstoffatome vorhanden, so können Enantiomere und Diastereomere auftreten. Stereoisomere lassen sich aus den bei der Herstellung anfallenden Gemischen nach üblichen Trennmethoden erhalten. Die chromatographische Trennung kann sowohl im analytischen Maßstab zur Feststellung des Enantiomerenüberschusses bzw. des Diastereomerenüberschusses, wie auch im präparativen Maßstab zur Herstellung von Prüfmustern für die biologische Ausprüfung erfolgen. Ebenso können Stereoisomere durch Einsatz stereoselektiver Reaktionen unter Verwendung optisch aktiver Ausgangs- und/oder Hilfsstoffe selektiv hergestellt werden. Die Erfindung betrifft somit auch alle Stereoisomeren, die von der allgemeinen Formel (I) umfasst, jedoch nicht mit ihrer spezifischen Stereoform angegeben sind, sowie deren Gemische. Sofern die Verbindungen als Feststoffe erhalten werden, kann die Reinigung auch durch Umkristallisieren oder Digerieren erfolgen. Sofern einzelne Verbindungen (I) nicht auf den nachstehend beschriebenen Wegen zufriedenstellend zugänglich sind, können sie durch Derivatisierung anderer Verbindungen (I) hergestellt werden. Als Isolierungs-, Reinigungs- und Stereoisomerenauftrennungsverfahren von Verbindungen der Formel (I) kommen Methoden in Frage, die dem Fachmann aus analogen Fällen allgemein bekannt sind, z.B. durch physikalische Verfahren wie Kristallisation, Chromatographieverfahren, vor allem Säulenchromatographie und HPLC (Hochdruckflüssigchromatographie), Destillation, gegebenenfalls unter reduziertem Druck, Extraktion und andere Verfahren, können gegebenenfalls verbleibende Gemische in der Regel durch chromatographische Trennung, z.B. an chiralen Festphasen, getrennt werden. Für präparative Mengen oder im industriellen Maßstab kommen Verfahren in Frage wie Kristallisation, z.B. diastereomerer Salze, die aus den Diastereomerengemischen mit optisch aktiven Säuren und gegebenenfalls bei vorhandenen sauren Gruppen mit optisch aktiven Basen erhalten werden können. Synthese Die erfindungsgemäßen Verbindungen der allgemeinen Formel (I) können über verschiedene literaturbeschriebene Synthesewege ausgehend von kommerziell verfügbaren oder leicht herstellbaren Ausgangssubstanzen hergestellt werden. Die substituierten Pyrrolidinone der allgemeinen Formel (I.1) können mit Hilfe einer literaturbeschriebenen Synthese (J. Org. Chem.1950, 2727) durch Umsetzung einer geeigneten, gegebenenfalls weiter substituierten trans-Hexendisäure mit einem geeigneten, gegebenenfalls weiter substituierten Amin, bevorzugt einem Benzyl- oder Heteroarylmethylamin, bei erhöhter Temperatur in einem geeigneten polar-protischen Lösemittel (z.B. Wasser oder Essigsäure) hergestellt werden (Schema 1). Die Ringschlussreaktion wurde dabei in einem geeigneten abgeschlossenen Gefäß unter Mikrowellenbedingungen durchgeführt. Im nachfolgenden Syntheseschema 1 haben die Gruppen R 1 , R 3 , R 4 , R 5 , R 6 , R 13 , R 14 , R 15 , R 35 , R 36 der allgemeinen Formel (I.1) die weiter oben beschriebenen Definitionen, während R 7 beispielhaft, aber nicht einschränkend für Wasserstoff steht. I Schema 1. Das aus der Ringschlussreaktion hervorgehende Pyrrolidinon (I.1a) kann danach mit Hilfe geeigneter Kupplungsreagenzien [z.B.1-Ethyl-3-(3-dimethylaminopropyl)carbodiimid (EDC), 2,4,6-Tripropyl- 1,3,5,2 λ5 ,4 λ5 ,6 λ5 -trioxatriphosphinan-2,4,6-trioxid (T3P), Hydroxybenzotriazol (HOBt)] unter Verwendung einer geeigneten Base (z.B. Triethylamin oder Diisopropylethylamin) in einem geeigneten polar-aprotischen Lösemittel (z.B. Dichlormethan) in die entsprechenden Ester (I.1b) oder Amide (I.1c) überführt werden. Alternativ können Oxopyrrolidinylesigsäureester (I.1d) mit Hilfe einer zweistufigen Kettenverlängerung aus den entsprechenden Oxopyrrolidinylcarboxylaten (C), hergestellt werden. Dabei wird zuerst der betreffende Carbonsäureester (C) mit Hilfe eines geeigneten Reduktionsmittels (z. B. Natrium oder Lithiumborhydrid) in den intermediären Alkohol (D) überführt, der danach mit Triethylphosphonoacetat und einer geeigneten Base, z.B. Natriumhydrid zum gewünschte Zielprodukt (I.1d) reagiert (Chemistry - A European Journal (2017), 23, 7428-7432I). Im folgenden Schema 2 sind die Reste R 13 und R 14 beispielhaft, aber nicht einschränkend durch Wasserstoff dargestellt, während R 1 , R 3 , R 4 , R 5 , R 6 und R 36 die weiter oben beschriebenen Bedeutungen haben. Schema 2. Die substituierten Pyrrolidinone der allgemeinen Formeln (I.3), (I.4) und (I.5) können auch über literaturbeschriebene Synthesewege hergestellt werden (vgl. WO2012098132). Durch Umsetzung einer geeigneten, gegebenenfalls weiter substituierten Itaconsäure (E) mit einem geeigneten, gegebenenfalls weiter substituierten Amin, bevorzugt einem Alkyl-, Cycloalkyl, Aryl- oder Heteroarylmethylamin, bei erhöhter Temperatur (z.B.150 °C) wird die entsprechende 5-Oxopyrrolidinyl-3-carbonsäure (F) erhalten (Schema 3). Die Ringschlussreaktion kann dabei in einer klassischen Syntheseapparatur mit Heizbad oder in einem geeigneten abgeschlossenen Gefäß unter Mikrowellenbedingungen durchgeführt werden. Die aus der Ringschlussreaktion hervorgehende intermediäre Carbonsäure (E) kann danach mit Hilfe geeigneter Kupplungsreagenzien [z.B.1-Ethyl-3-(3-dimethylaminopropyl)carbodiimid (EDC), 2,4,6- Tripropyl-1,3,5,2 λ5 ,4 λ5 ,6 λ5 -trioxatriphosphinan-2,4,6-trioxid (T3P), Hydroxybenzotriazol (HOBt)] unter Verwendung einer geeigneten Base (z.B. Triethylamin oder Diisopropylethylamin) zusammen mit dem entsprechenden gegebenenfalls weiter substituierten Amin in einem geeigneten polar-aprotischen Lösemittel (z.B. Dichlormethan) in die entsprechenden Amide (I.2) überführt werden. Weiterhin kann die Carbonsäure (E) über eine durch geeignete Reagenzien [z.B. Diphenylphosphorylazid (DPPA), Triethylamin und tert. Butanol] vermittelte und bei erhöhter Temperatur (z.B.80 °C) durchgeführte Abbaureaktion in das entsprechende geschützte Amin (F) umgesetzt werden. Durch Abspaltung der betreffenden Schutzgruppe [hier beispielhaft, aber nicht einschränkend eine tert-Butyloxycarbonyl (Boc)-Schutzgruppe] unter Verwendung eines geeigneten Reagens (z.B. beispielhaft, aber nicht einschränkend Salzsäure in Essigester zur Abspaltung der Boc-Gruppe) wird das entsprechende Amin (G) erhalten (gegebenenfalls auch als Salz, z.B. beispielhaft, aber nicht einschränkend als HCl-Salz). Das Amin (G) kann mit Hilfe geeigneter Kupplungspartner (beispielhaft, aber nicht einschränkend mit einem gegebenenfalls weiter substituierten Essigsäurechlorid, einem gegebenenfalls weitersubstituierten Isocyanat oder einem gegebenenfalls weiter substituierten Isothiocyanat) unter Verwendung einer geeigneten Base (z.B. Triethylamin oder Diisopropylethylamin) in einem geeigneten polar-aprotischen Lösemittel (z.B. Dichlormethan, Acetonitril) in die entsprechenden erfindungsgemäßen, gegebenenfalls weiter substituierten Acetamide (I.3), Harnstoffe (I.4) und Thioharnstoffe (I.5) überführt werden (vgl. WO2004026825, US20110189167, WO2009138438). Im nachfolgenden Schema 3 haben die Gruppen R 1 , R 3 , R 5 , R 6 , R 11 , R 12 , R 20 , R 21 , R 22 , R 37 der allgemeinen Formeln (I.2), (I.3), (I.4) und (I.5) die weiter oben beschriebenen Definitionen, während R 2 , R 4 , R 8 , R 9 und R 10 beispielhaft, aber nicht einschränkend, für Wasserstoff stehen. Schema 3. Alternativ kann das gegebenenfalls weiter substituierte Intermediat (G) auch ausgehend von einem weiter substituierten Glycinester (H) in einer mehrstufigen Reaktion über Acylierung, nachfolgende Cyclisierung mit Hilfe einer geeigneten Base (z.B. Natriumhydrid) in einem geeigneten polar- aprotischen Lösemittel (z.B. Tetrahydrofuran), Oximbildung mit Hilfe von Hydroxylamin-Hydrochlorid und einer geeigneten Base in einem geeigneten polar-aprotischen Lösemittel (z.B. Dichlormethan) sowie abschließende Reduktion des Oxims mit einem geeigneten Reduktionsmittel (z.B. Natriumcyanoborhydrid und Wasserstoff über Palladium auf Kohle) hergestellt werden (Schema 4). Im nachfolgenden Schema 4 haben die Gruppen R 1 , R 3 , R 5 , R 11 , R 12 , R 37 die weiter oben beschriebenen Definitionen, während R 2 , R 4 , R 6 , R 8 , R 9 und R 10 beispielhaft, aber nicht einschränkend für Wasserstoff stehen. i Schema 4. Alternativ können die gegebenenfalls weiter substituierten Harnstoffe der allgemeinen Formel (I.4) ausgehend von einer substituierten und mit geeigneten Schutzgruppen versehenen Aminosäure (J) hergestellt werden (vgl. WO2006063113). Dabei erfolgt zuerst die basenvermittelte Reaktion der Aminosäure (J) mit einem geeigneten Isocyanat zu einem gegebenenfalls weiter substituierten Intermediat (K). Die so erhaltene intermediäre, gegebenenfalls weiter substituierte Carbonsäure (K) kann danach mit Hilfe geeigneter Kupplungsreagenzien [z.B.1-Ethyl-3-(3- dimethylaminopropyl)carbodiimid (EDC), 2,4,6-Tripropyl-1,3,5,2 λ5 ,4 λ5 ,6 λ5 -trioxatriphosphinan-2,4,6- trioxid (T3P), Hydroxybenzotriazol (HOBt)] unter Verwendung einer geeigneten Base (z.B. Triethylamin oder Diisopropylethylamin) zusammen mit dem entsprechenden Amin R 1 -NH2 in einem geeigneten polar-aprotischen Lösemittel (z.B. Dichlormethan) in das entsprechende, gegebenenfalls weiter substituierte Intermediat (L) überführt werden, das nach Abspaltung der Schutzgruppe der weiteren Säurefunktion (beispielhaft, aber nicht einschränkend mit Wasserstoff über Palladium auf Kohle in einem geeigneten polar-protischen Lösemittel wie Methanol zur Abspaltung einer Benzylschutzgruppe) mit Hilfe einer geeigneten Base cyclisiert wird. Durch die abschließende Cyclisierung erhält man erfindungsgemäße, gegebenenfalls weiter substituierte Verbindungen der allgemeinen Formel (I.4) (Schema 5). Im nachfolgenden Syntheseschema 4 haben die Gruppen R 1 , R 5 , R 37 die weiter oben beschriebenen Definitionen, während R 2 , R 3 , R 4 , R 6 , R 8 und R 9 beispielhaft, aber nicht einschränkend für Wasserstoff stehen. Schema 5. Die Verbindungen vom Typ I.2 konnten auch in Analogie zu den Vorschriften aus der Patentanmeldung WO2011/35332 (Schema 6) hergestellt werden. Hierbei werden, wie im Schema 6 dargestellt, durch Kondensation der entsprechenden Aniline mit Itaconsäurederivaten (M) die korrespondierenden Pyrrolidoncarbonsäuren (O) hergestellt. Nach Veresterung der Säuren (O) z.B. unter mithilfe von Orthoester oder durch andere Methoden, erhält man die entsprechenden Carbonsäureester (P). Diese werden nach Deprotonierung mit einer starken Base wie z.B. Natriumhydrid oder Lithiumhexamethyldisilazid oder Lithiumdiisopropylamid oder mit einer geeigneten anderen anorganischen oder organischen Base in einem inerten Lösungsmittel wie THF, Diethylether oder Dimethylformamid oder einem anderen geeigneten Lösungsmittel bei Temperaturen zwischen -78 °C und 180 °C mit einem Alkylierungsmittel wie einem Alkylhalogenid wie Methyliodid oder Dimethylsulfat zu den alkylierten Pyrrolidoncarbonsäureestern (Q) umgesetzt. Nach Verseifung zu den korrespondierenden Säuren mit anorganischen Basen wir Natriumhydroxid oder Lithiumhydroxid in einem geeigneten Lösungsmittel wir Wasser, Ethanol oder THF erhält man die freie Carbonsäure oder deren Salz (R), die dann unter Standardbedingungen mit einem Kupplungsreagenz wir T3P, Carbonyldiimidazol, HATU und anderen geeignete Methoden zu den Amiden (I.2) umgesetzt werden. H Schema 6. In Schema 7 wird die Synthese von einigen nicht-kommerziellen Aminen aufgeführt. Ausgehend vom Pyrimidon (S) lassen sich durch Oximierung, nachfolgende Chlorierung, Reduktion, Einführung der Boc-Schutzgruppe und nucleophile Substitution mit einer Vielzahl an O-, S- und N-Nucleophilen in die entsprechenden Pyrimidinmethylamine (T) umwandeln. Nu- = Cl, O-, S- und N-Nucleophile Schema 7. Ausgewählte detaillierte Synthesebeispiele für die erfindungsgemäßen Verbindungen der allgemeinen Formeln (I) sind im Folgenden aufgeführt. Die angegebenen Beispielnummern entsprechen den in den nachstehenden Tabellen I.1 bis I.5 genannten Nummerierungen. Die 1 H-NMR-, 13 C-NMR- und 19 F- NMR-spektroskopischen Daten, die für die in den nachfolgenden Abschnitten beschriebenen chemischen Beispiele angegeben sind, (400 MHz bei 1 H-NMR und 150 MHz bei 13 C-NMR und 375 MHz bei 19 F-NMR, Lösungsmittel CDCl 3 , CD 3 OD oder d 6 -DMSO, interner Standard: Tetramethylsilan δ = 0.00 ppm), wurden mit einem Gerät der Firma Bruker erhalten, und die bezeichneten Signale haben die nachfolgend aufgeführten Bedeutungen: br = breit(es); s = Singulett, d = Dublett, t = Triplett, dd = Doppeldublett, ddd = Dublett eines Doppeldubletts, m = Multiplett, q = Quartett, quint = Quintett, sext = Sextett, sept = Septett, dq = Doppelquartett, dt = Doppeltriplett. Bei Diastereomerengemischen werden entweder die jeweils signifikanten Signale beider Diastereomere oder das charakteristische Signal des Hauptdiastereomers angegeben. Die verwendeten Abkürzungen für chemische Gruppen haben beispielsweise die nachfolgenden Bedeutungen: Me = CH 3 , Et = CH2CH 3 , t-Hex = C(CH 3 ) 2 CH(CH 3 ) 2 , t- Bu = C(CH 3 )3, n-Bu = unverzweigtes Butyl, n-Pr = unverzweigtes Propyl, i-Pr = verzweigtes Propyl, c- Pr = Cyclopropyl, c-Hex = Cyclohexyl. Ausgewählte Synthesebeispiele: I.1-001: 2-[1-[(3-Chlor-2-fluorphenyl)methyl]-5-oxo-pyrrolidin-2-yl]e ssigsäure 3-Chlor-2-fluorbenzylamin (221 mg, 1.39 mmol, 1.0 eq.) und Trans-3-Hexendisäure (200 mg, 1.39 mmol, 1.0 eq.) wurden in Wasser suspendiert (5.0 mL) und in ein Mikrowellengefäß überführt, das danach fest verschlossen wurde. Das Reaktionsgemisch wurde 1 h lang unter Mikrowellenbedingungen auf 190 °C erhitzt. Der Innendruck stieg dabei auf ca.18 bar an. Nach dem Abkühlen auf Raumtemperatur wurde das Reaktionsgemisch eingeengt und über eine präparative HPLC gereinigt. Auf diese Weise wurde racemische 2-[1-[(3-Chlor-2-fluorphenyl)methyl]-5-oxo- pyrrolidin-2-yl]essigsäure I.1-001 (135 mg, 34% der Theorie) in Form eines farblosen Öls erhalten. 1 H-NMR (400.0 MHz, CDCl3) δ ppm 7.36-7.32 (m, 1H), 7.22-7.18 (m, 1H), 7.09-7.04 (m, 1H), 4.91-4.87 (d, 1H), 4.27-4.23 (d, 1H), 3.94-3.88 (m, 1H), 2.78-2.73 (dd, 1H), 2.62-2.42 (m, 3H), 2.37-2.26 (m, 1H), 1.93-1.85 (m, 1H). Nr. I.1-604 und Nr. I.1-605: (+)- und (-)-2-[1-[(3-Chlor-2-fluorphenyl)methyl]-5-oxo-pyrrolidin-2- yl]essigsäure: Die oben aufgeführte Reaktion wurde unter Verwendung der gleichen Menge an Reagenzien wiederholt und eine vereinigte Menge an 2-[1-[(3-Chlor-2-fluorphenyl)methyl]-5-oxo-pyrrolidin-2-yl]e ssigsäure (I.1-001, 200 mg) wurde über präparative chirale SFC-Trennung unter Verwendung einer chiralen Opti Prep ODB Säule (Gradient Chir_C3_IE_B1_90_CO2_MeOH_6min_CD) in die Enantiomere Ent-1 I.1- 604 (85 mg, Retentionszeit 1.177, Drehwert 28.50° - 20mg/10 mL), 1 H-NMR (400.0 MHz, CDCl3) δ ppm 7.38-7.33 (m, 1H), 7.22-7.17 (m, 1H), 7.09-7.03 (m, 1H), 4.92-4.88 (d, 1H), 4.27-4.23 (d, 1H), 3.94-3.88 (m, 1H), 2.78-2.73 (dd, 1H), 2.62-2.42 (m, 3H), 2.39-2.25 (m, 1H), 1.93-1.85 (m, 1H) und Ent-2 I.1-605 (91 mg, Retentionszeit 1.862, Drehwert -36.00° - 22 mg/100 mL) getrennt, 1 H-NMR (400.0 MHz, CDCl3) δ ppm 7.36-7.31 (m, 1H), 7.23-7.15 (m, 1H), 7.09-7.04 (m, 1H), 4.91-4.85 (d, 1H), 4.27-4.23 (d, 1H), 3.93-3.87 (m, 1H), 2.77-2.72 (dd, 1H), 2.64-2.43 (m, 3H), 2.37-2.26 (m, 1H), 1.93- 1.84 (m, 1H). I.1-003 - 2-[1-[(2,3-Difluorphenyl)methyl]-5-oxo-pyrrolidin-2-yl]essig säure: 2,3-Difluorbenzylamin (993 mg, 6.93 mmol, 1.0 eq.) und Trans-3-Hexendisäure (1.00 g, 6.93 mmol, 1.0 eq.) wurden in Wasser suspendiert (10.0 mL) und in ein Mikrowellengefäß überführt, das danach verschlossen wurde. Das Reaktionsgemisch wurde 1 h lang unter Mikrowellenbedingungen auf 190 °C erhitzt. Der Innendruck stieg dabei auf ca.18 bar an. Nach dem Abkühlen auf Raumtemperatur wurde das Reaktionsgemisch eingeengt und über eine preparative HPLC gereinigt. Auf diese Weise wurde 2- [1-[(2,3-difluorphenyl)methyl]-5-oxo-pyrrolidin-2-yl]essigs ure (182.0 mg, 23% der Theorie) in Form eines farblosen Öls erhalten. 1 H-NMR (600.0 MHz, d6-DMSO): δ= 1.69 - 1.76 (m, 1 H), 2.14 - 2.29 (m, 2 H), 2.34 - 2.45 (m, 2 H), 2.69 (dd, J=15.97, 4.05 Hz, 1 H), 3.76 (tt, J=8.31, 4.14 Hz, 1 H), 4.24 (d, J=15.85 Hz, 1 H), 4.73 (d, J=15.85 Hz, 1 H), 7.08 (t, J=7.03 Hz, 1 H), 7.16 - 7.21 (m, 1 H), 7.36 (q, J=8.42 Hz, 1 H). I.1-036: 2-(4-Methylphenoxy)ethyl 2-[1-[(2,3-difluorphenyl)methyl]-5-oxo-pyrrolidin-2-yl]aceta t Zu einer Lösung von 2-[1-[(2,3-Difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]essigs äure (150.0 mg, 0.55 mmol, 1.0 eq.) in Dichlormethan (20 mL) wurden 2-(4-Methylphenoxy)ethanol (170.0 mg, 1.11 mmol, 2.0 eq.), DMAP (0.7 mg, 0.05 mmol, 0.1 eq.) und 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimid (117.0 mg, 0.61 mmol, 1.1 eq.) zugegeben. Die Reaktionsmischung wurde 5 h lang bei Raumtemperatur gerührt. Danach erfolgte die Zugabe von Wasser (20 mL), und die wässrige Phase wurde gründlich mit Dichlormethan (3 x 50 mL) extrahiert. Die vereinigten organischen Phasen wurden über Magnesiumsulfat getrocknet, filtriert und unter vermindertem Druck eingeengt. Durch säulenchromatographische Reinigung des verbleibenden Rückstands [Silica gel; Heptan/EtOAc (4:1)] wurde 2-(4-Methylphenoxy)ethyl 2-[1-[(2,3-difluorphenyl)methyl]-5-oxo-pyrrolidin-2-yl]aceta t I.1-036 (141.0 mg, 62% der Theorie) in Form eines farblosen Öls erhalten. 1 H-NMR(400.1 MHz, CDCl3): δ ppm 1.79 - 1.89 (m, 1 H), 2.22 - 2.31 (m, 4 H), 2.34 - 2.52 (m, 3 H), 2.75 (dd, J=15.57, 3.99 Hz, 1 H), 3.88 (dt, J=8.31, 4.16 Hz, 1 H), 4.09 - 4.15 (m, 2 H), 4.24 (d, J=15.49 Hz, 1 H), 4.37 - 4.44 (m, 2 H), 4.86 (dd, J=15.57, 1.55 Hz, 1 H), 6.75 - 6.82 (m, 2 H), 7.00 - 7.12 (m, 5 H). I.1-056: 2-[1-[(2,3-difluorphenyl)methyl]-5-oxo-pyrrolidin-2-yl]-N-(4 -methyl-1,2,5-oxadiazol-3- yl)acetamid Zu einer Lösung von 4-Methyl-1,2,5-oxadiazol-3-amin (74.0 mg, 0.74 mmol, 1.0 eq.) in Dichlormethan (6 mL) wurden 2-[1-[(2,3-difluorphenyl)methyl]-5-oxopyrrolidin-2-yl]essigs äure (200.0 mg, 0.74 mmol, 1.0 eq.) und 2,4,6-Tripropyl-1,3,5,2 λ5 ,4 λ5 ,6 λ5 -trioxatriphosphinan-2,4,6-trioxid (709.0 mg, 0.663 mL, 1.11 mmol, 1.5 eq., 50%-ige Lösung in EtOAc) gegeben. Das Reaktionsgemisch wurde 1 h lang bei Raumtemperatur gerührt. Danach erfolgten die tropfenweise Zugabe von Triethylamin (376.0 mg, 0.52 mL, 3.71 mmol, 5.0 eq.) sowie die Zugabe von DMAP (18.0 mg, 0.14 mmol.0.2 eq.), und das resultierende Reaktionsgemisch wurde 16 h bei Raumtemperatur gerührt. Danach erfolgte die Zugabe von Wasser (20 mL), und die wässrige Phase wurde gründlich mit Dichlormethan (3 x 50 mL) extrahiert. Die vereinigten organischen Phasen wurden über Magnesiumsulfat getrocknet, filtriert und unter vermindertem Druck eingeengt. Durch präparative HPLC-Reinigung des verbleibenden Rückstands wurde 2-[1-[(2,3-difluorphenyl)methyl]-5-oxo-pyrrolidin-2-yl]-N-(4 -methyl-1,2,5- oxadiazol-3-yl)acetamid I.1-056 (114.0 mg, 43% der Theorie) in Form eines gelblichen Öls erhalten. 1 H-NMR(400.1 MHz, d 6 -DMSO): δ ppm 1.77 - 1.87 (m, 1 H), 2.18 - 2.37 (m, 5 H), 2.37 - 2.44 (m, 1 H), 2.54 - 2.62 (m, 1 H), 2.88 (dd, J=14.92, 4.16 Hz, 1 H), 3.90 (br d, J=3.91 Hz, 1 H), 4.28 (d, J=15.98 Hz, 1 H), 4.73 (d, J=16.14 Hz, 1 H), 7.05 - 7.11 (m, 1 H), 7.15 - 7.22 (m, 1 H), 7.30 - 7.39 (m, 1 H). I.1-133: 2-[1-[(2,3-dichlorphenyl)methyl]-5-oxo-pyrrolidin-2-yl]essig säure 2,3-Dichlorbenzylamin (1.21 g, 6.93 mmol, 1.0 eq.) und Trans-3-Hexendisäure (1.00 g, 6.93 mmol, 1.0 eq.) wurden in Wasser suspendiert (10.0 mL) und in ein Mikrowellengefäß überführt, das danach verschlossen wurde. Das Reaktionsgemisch wurde 1 h lang unter Mikrowellenbedingungen auf 190 °C erhitzt. Der Innendruck stieg dabei auf ca.18 bar an. Nach dem Abkühlen auf Raumtemperatur wurde das Reaktionsgemisch eingeengt und über eine preparative HPLC gereinigt. Auf diese Weise wurde 2- [1-[(2,3-dichlorphenyl)methyl]-5-oxo-pyrrolidin-2-yl]essigs ure I.1-133 (847.0 mg, 40% der Theorie) in Form eines farblosen Feststoffs. 1 H-NMR (400.1 MHz, d6-DMSO): δ ppm 1.72 - 1.82 (m, 1 H), 2.19 - 2.34 (m, 2 H), 2.36 - 2.45 (m, 2 H), 2.65 (dd, J=16.06, 4.32 Hz, 1 H), 3.81 (tt, J=8.09, 4.22 Hz, 2 H), 4.29 (d, J=16.47 Hz, 1 H), 4.68 (d, J=16.47 Hz, 1 H), 7.22 (dd, J=7.66, 1.47 Hz, 1 H), 7.35 (t, J=7.91 Hz, 1 H), 7.57 (dd, J=7.99, 1.47 Hz, 1 H). I.1-311: 2-[1-[(2,3-Dichlorphenyl)methyl]-5-oxo-pyrrolidin-2-yl]-N-(d imethylsulfamoyl)acetamid Zu einer Lösung von 2-[1-[(2,3-Dichlorphenyl)methyl]-5-oxopyrrolidin-2-yl]essigs äure (250.0 mg, 0.82 mmol, 1.0 eq.) in abs. Dichlormethan (30 mL) wurden N,N-Dimethylsulfamid (205.0 mg, 1.65 mmol, 2.0 eq.), DMAP (0.1 mg, 0.08 mmol, 0.1 eq.) und 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimid (174.0 mg, 0.91 mmol, 1.1 eq.) gegeben. Das resultierende Reaktionsgemisch wurde 16 h bei Raumtemperatur gerührt. Danach erfolgte die Zugabe von Wasser (20 mL), und die wässrige Phase wurde gründlich mit Dichlormethan (3 x 50 mL) extrahiert. Die vereinigten organischen Phasen wurden über Magnesiumsulfat getrocknet, filtriert und unter vermindertem Druck eingeengt. Durch präparative HPLC-Reinigung des verbleibenden Rückstands wurde 2-[1-[(2,3-dichlorphenyl)methyl]-5-oxo- pyrrolidin-2-yl]-N-(dimethylsulfamoyl)acetamid I.1-311 (151.0 mg, 44% der Theorie) als farbloser Feststoff erhalten. 1 H-NMR (400 MHz, d 6 -DMSO) δ ppm 1.75 - 1.83 (m, 1 H), 2.18 - 2.46 (m, 4 H), 2.66 - 2.73 (m, 1 H), 3.85 (tt, J=8.15, 4.08 Hz, 1 H), 4.27 (d, J=16.63 Hz, 1 H), 4.66 (d, J=16.63 Hz, 1 H), 7.17 - 7.21 (m, 1 H), 7.36 (t, J=15.81 Hz, 1 H), 7.56 - 7.60 (m, 1 H). I.1-599: [5-Oxo-1-(2,3,6-trifluorbenzyl)pyrrolidin-2-yl]essigsäure. Trans-3-Hexendisäure (300 mg, 2.08 mmol) und 1-(2,3,6-Trifluorphenyl)methylamin (335 mg, 2.08 mmol) wurden zusammen mit Wasser (5 ml) in ein Mikrowellengefäß gegeben und 1 h lang bei bei einer Temperatur von 190 °C umgesetzt. Dabei stieg der Druck bis auf 18 bar an. Nach dem Abkühlen auf Raumtemperatur wurde das Reaktionsgemisch unter vermindertem Druck eingeengt. Durch präparative HPLC-Reinigung wurde [5-Oxo-1-(2,3,6-trifluorbenzyl)pyrrolidin-2-yl]essigsäure in Form eines farblosen Feststoffs (144 mg, 25% der Theorie) erhalten, 1 H-NMR (400 MHz, CDCl 3 ) δ ppm 7.18- 7.10 (m, 1H), 6.90-6.84 (m, 1H), 5.19 (d, 1H), 4.17 (d, 1H), 3.86-3.80 (m, 1H), 2.84-2.79 (dd, 1H), 2.62- 2.43 (m, 3H), 2.33-2.25 (m, 1H), 1.93-1.86 (m, 1H). I.1-600: [5-Oxo-1-(2,3,4-trifluorbenzyl)pyrrolidin-2-yl]essigsäure. Trans-3-Hexendisäure (100 mg, 0.69 mmol) und 1-(2,3,4-Trifluorphenyl)methylamin (112 mg, 0.69 mmol) wurden zusammen mit Wasser (5 ml) in ein Mikrowellengefäß gegeben und 1 h lang bei bei einer Temperatur von 190 °C umgesetzt. Dabei stieg der Druck bis auf 18 bar an. Nach dem Abkühlen auf Raumtemperatur wurde das Reaktionsgemisch unter vermindertem Druck eingeengt. Durch präparative HPLC-Reinigung wurde [5-Oxo-1-(2,3,4-trifluorbenzyl)pyrrolidin-2-yl]essigsäure in Form eines farblosen Feststoffs (52 mg, 27% der Theorie) erhalten, 1 H-NMR (400 MHz, CDCl3) δ ppm 7.09- 7.03 (m, 1H), 6.98-6.92 (m, 1H), 4.87 (d, 1H), 4.21 (d, 1H), 3.93-3.87 (m, 1H), 2.80-2.75 (dd, 1H), 2.61- 2.40 (m, 3H), 2.38-2.27 (m, 1H), 1.94-1.86 (m, 1H). I.1-601: [5-Oxo-1-(2,3,5-trifluorbenzyl)pyrrolidin-2-yl]essigsäure. Trans-3-Hexendisäure (200 mg, 1.39 mmol) und 1-(2,3,5-Trifluorphenyl)methylamin (224 mg, 1.39 mmol) wurden zusammen mit Wasser (5 ml) in ein Mikrowellengefäß gegeben und 1 h lang bei bei einer Temperatur von 190 °C umgesetzt. Dabei stieg der Druck bis auf 18 bar an. Nach dem Abkühlen auf Raumtemperatur wurde das Reaktionsgemisch unter vermindertem Druck eingeengt. Durch präparative HPLC-Reinigung wurde [5-Oxo-1-(2,3,5-trifluorbenzyl)pyrrolidin-2-yl]essigsäure in Form eines farblosen Feststoffs (116 mg, 32% der Theorie) erhalten, 1 H-NMR (400 MHz, CDCl 3 ) δ ppm 6.90- 6.79 (m, 2H), 4.85 (d, 1H), 4.29 (d, 1H), 3.95-3.88 (m, 1H), 2.78-2.74 (dd, 1H), 2.61-2.42 (m, 3H), 2.39- 2.30 (m, 1H), 1.94-1.86 (m, 1H). I.1-602: [5-Oxo-1-(2,3-dimethylbenzyl)pyrrolidin-2-yl]essigsäure. Trans-3-Hexendisäure (300 mg, 2.08 mmol) und 1-(2,3-Dimethylphenyl)methylamin (281 mg, 2.08 mmol) wurden zusammen mit Wasser (5 ml) in ein Mikrowellengefäß gegeben und 1 h lang bei bei einer Temperatur von 190 °C umgesetzt. Dabei stieg der Druck bis auf 18 bar an. Nach dem Abkühlen auf Raumtemperatur wurde das Reaktionsgemisch unter vermindertem Druck eingeengt. Durch präparative HPLC-Reinigung wurde [5-Oxo-1-(2,3-dimethylbenzyl)pyrrolidin-2-yl]essigsäure in Form eines farblosen Feststoffs (131 mg, 24% der Theorie) erhalten, 1 H-NMR (400 MHz, CDCl3) δ ppm 7.13- 7.11 (d, 1H), 7.09-7.05 (dd, 1H), 6.98-6.96 (d, 1H), 5.04 (d, 1H), 4.08 (d, 1H), 3.80-3.75 (m, 1H), 2.68- 2.50 (m, 3H), 2.48-2.41 (dd, 1H), 2.31-2.23 (m, 1H), 2.28 (s, 3H), 2.15 (s, 3H), 1.95-1.88 (m, 1H). I.1-603: 2-[1-[(2,3-Difluorphenyl)methyl]-5-oxo-pyrrolidin-2-yl]-N-(1 ,2,4-thiadiazol-5-yl)acetamid Zu einer Lösung von 5-Amino-1,2,4-thiazolylhydrochlorid (120 mg, 0.87 mmol, 1.0 eq.) in Dichlormethan (5 mL) wurden 2-[1-[(2,3-Difluorphenyl)methyl]-5-oxo-pyrrolidin-2-yl]essig säure (235 mg, 0.87 mmol, 1.0 eq.) und cyclisches 1-Propylphosphonsäureanhydrid (T3P®, 722 mg, 0.68 mL, 1.13 mmol, 1.3 eq., 50%-Lösung in Tetrahydrofuran) gegeben. Das Reaktionsgemisch wurde 1 h land bei Raumtemperatur gerührt und danach mit Tiethylamin (0.37 mL, 2.62 mmol, 3.0 eq.) tropfenweise versetzt. Das resultierende Reaktionsgemisch wurde weitere 8 h lang bei Raumtemperatur und danach mit Wasser (20 mL) versetzt und mehrfach gründlich mit Dichlormethan extrahiert (3 x 50 mL). Die vereinigten organischen Phasen wurden über Magnesiumsulfat getrocknet, abfiltriert und unter vermindertem Druck eingeengt. Durch Reinigung des resultierenden Rohproduktes mit Hilfe einer präparativen HPLC-Trennung wurde 2-[1-[(2,3-Difluorphenyl)methyl]-5-oxo-pyrrolidin-2-yl]-N-(1 ,2,4- thiadiazol-5-yl)acetamid I.1-603 (110 mg, 35% der Theorie) in Form eines farblosen Feststoffs erhalten. 1 H-NMR (400.0 MHz, CDCl3) δ ppm 11.77 (br. s, 1H, NH), 8.21 (s, 1H), 7.08-7.01 (m, 3H), 4.84-4.80 (d, 1H), 4.36-4.32 (d, 1H), 4.16-4.12 (m, 1H), 3.04-2.99 (dd, 1H), 2.72-2.66 (dd, 1H), 2.62-2.48 (m, 2H), 2.44-2.37 (m, 1H), 1.95-1.88 (m, 1H). I.2-32: N-[(2-Chlorpyridin-4-yl)methyl]-6-(3,5-dichlorphenyl)-2,4-di methyl-7-oxo-6-azabicyclo [3.2.1]oct-3-en-8-carboxamid Unter Stickstoff wurden 91.0 mg (0.27 mmol) 6-(3,5-Dichlorphenyl)-2,4-dimethyl-7-oxo-6- azabicyclo[3.2.1]oct-3-en-8-carbonsäure in 2 mL trockenem Dichlormethan vorgelegt, dann nacheinander mit 36.1 mg (0.27 mmol) HOBT in 1 ml Dichlormethan, 52.7 mg (0.29 mmol) 1-(2- Chlorpyridin-4-yl)methanaminhydrochlorid, 103.7 mg (0.8 mmol) Ethyldiisopropylamin und zuletzt mit 66.7 mg (0.35 mmol) EDCl versetzt und 12 h bei Raumtemperatur gerührt. Anschließend wurde die Lösung eingedampft und über Kieselgel gereinigt. Nach Reinigung über Kieselgel wurden 120 mg (Reinheit 95%, 92% der Theorie) des Produktes N-[(2-Chlorpyridin-4-yl)methyl]-6-(3,5-dichlorphenyl)- 2,4-dimethyl-7-oxo-6-azabicyclo[3.2.1]oct-3-en-8-carboxamid erhalten. 1 H-NMR (400.0 MHz, CDCl 3 ) δ 8.2776 (2.8); 8.2761 (2.7); 8.2648 (2.9); 8.2634 (2.8); 7.5270 (11.8); 7.5225 (11.8); 7.5190 (1.6); 7.2715 (1.1); 7.2707 (1.2); 7.2601 (201.1); 7.2100 (1.0); 7.1440 (3.4); 7.1395 (8.3); 7.1349 (5.1); 7.0283 (1.9); 7.0264 (1.6 ); 7.0246 (1.8); 7.0155 (1.8); 7.0137 (1.5); 7.0118 (1.6); 6.9961 (1.1); 6.2238 (0.8); 5.3596 (1.8); 5.3563 (1.8); 4.5527 (2.7); 4.4646 (1.9); 4.4477 (2.8); 4.4310 (1.9); 3.0052 (4.5); 2.9545 (1.4); 2.9424 (1.6); 2.7799 (0.6); 2.7741 (0.7); 2.7679 (0.8); 2.7618 (0.8); 2.7558 (0.7); 2.7497 (0.6); 2.0905 (1.2); 1.8615 (6.3); 1.8572 (7.7); 1.8555 (7.6); 1.8513 (6.2); 1.5970 (0.6); 1.5807 (0.7); 1.5473 (16.0); 1.5242 (0.9); 1.5072 (0.7); 1.2554 (0.7); 1.2076 (9.5); 1.1894 (9.3); 0.0079 (2.4); -0.0002 (85.7); -0.0085 (2.6). I.2-33: 1-[3,5-Bis(trifluormethyl)phenyl]-N-{[2-(ethylamino)pyrimidi n-4-yl]methyl}-5-oxopyrrolidin-3- carboxamid Hierzu wurden 202.0 mg (0.29 mmol) Ethan-1,2-diylbis{1-[3,5-bis(trifluormethyl)phenyl]-5- oxopyrrolidin-3-carboxylat} in 6 mL THF und 2 mL Wasser gelöst und zunächst im Eisbad mit 0.3 mL 2M Natronlauge (=24 mg NaOH (0.6 mmol)) gerührt. Man lässt auf Raumtemperatur aufwärmen und kühlt nach 1 h auf 0 °C ab. Die Lösung wurde mit 2M Salzsäure neutralisiert. Anschließend wurde die Reaktionsmischung eingedampft, mit Wasser aufgenommen und mit 2M Salzsäure auf pH 2 gebracht. Der Feststoff wurde abgesaugt und im Vakuum getrocknet. Man erhielt 183.0 mg (Reinheit 95 %, 90% der Theorie) der gewünschten 1-[3,5-Bis(trifluormethyl)phenyl]-5-oxopyrrolidin-3-carbons ure. 1 H-NMR (400.0 MHz, d 1 -Chlorform): δ= 2.95 - 3.09 (m, 2 H) 3.44 - 3.54 (m, 1 H) 4.12 - 4.26 (m, 2 H) 7.68 (bs, 1 H) 8.12 (bs, 2 H).10.0 g (72.0 mmol) 2-Chlorpyrimidin-4-carbonitril in Methanol (50 mL) wurden vorsichtig bei 0 °C mit 30 mL 30% Ethylamin in Methanol (ca.200 mmol) versetzt und 2 h bei dieser Temperatur gerührt. Danach wurde die Reaktionsmischung in Wasser gegeben (50 mL). Der gebildete, gelbe Feststoff 2-(Ethylamino)pyrimidin-4-carbonitril wurde ohne weitere Reinigung abfiltriert und getrocknet. Dieses Rohprodukt wurde mit 2.8 g Pd/C (10 wt%) und 14.6 g (144.3 mmol, 20 mL) Triethylamin in Ethanol (200 mL) versetzt und bei Normaldruck und Raumtemperatur über Nacht hydriert (Luftballon). Anschließend wurde die Reaktionsmischung filtriert und das Filtrat eingeengt. Der Rückstand wurde in EtOAc (100 mL) gelöst und mit 15.0 mL 4M (60 mmol) Salzsäure in Dioxan gerührt. Der gebildete Feststoff wurde abfiltriert und getrocknet. Man erhielt 6.5 g (48% der Theorie) 4-(Aminomethyl)-N-ethylpyrimidin-2-amin Hydrochlorid als braunen Feststoff. MS-ESI: [M+H] + 152. 1 H-NMR (500.0 MHz, d 6 -DMSO): δ= 10.08 (s, 1H), 8.71 (s, 3H), 8.40 (d, J = 4.5 Hz, 1H), 6.92 (d, J = 5.5 Hz, 1H), 4.16 (s, 2H), 3.50 (s, 2H), 1.18-1.14(m, 3H). Unter Stickstoff wurden 61.0 mg (0.17 mmol) 1-[3,5-Bis(trifluormethyl)phenyl]-5-oxopyrrolidin-3-carbons ure in 3 mL trockenem THF vorgelegt, dann nacheinander mit 24.2 mg (0.17 mmol) HOBT in 1 mL THF, 37.1 mg (0.19mmol) 4- (Aminomethyl)-N-ethylpyrimidin-2-amin Hydrochlorid, 92.4 mg (0.71 mmol) Ethyldiisopropylamin und zuletzt mit 44.6 mg (0.23 mmol) EDCl in 6 mL THF versetzt und 12 h bei Raumtemperatur gerührt. Anschließend wurde die Lösung einrotiert, mit 2 mL Dichlormethan aufgenommen und direkt über Kieselgel gereinigt. Man erhielt 79.0 mg (Reinheit 90%, 84 % der Theorie) des Produktes N1-[3,5- Bis(trifluormethyl)phenyl]-N-{[2-(ethylamino)pyrimidin-4-yl] methyl}-5-oxopyrrolidin-3-carboxamid in Form eines farblosen Feststoffs. 1 H-NMR(400.0 MHz, CDCl 3 ): δ 8.2489 (1.7); 8.2364 (1.7); 8.1401 (6.4); 7.9001 (0.5); 7.8791 (0.6); 7.6685 (0.6); 7.6510 (2.9); 7.2621 (49.4); 7.0400 (0.9); 6.4962 (3.4); 6.4835 (3.4); 4.4364 (3.1); 4.4337 (3.2); 4.4246 (3.2); 4.4219 (3.2); 4.2766 (1.7); 4.2588 (1.8); 4.2528 (2.2); 4.2349 (2.2); 4.0945 (2.0); 4.0730 (2.6); 4.0708 (2.2); 4.0492 (1.7); 3.4862 (1.3); 3.4784 (1.4); 3.4687 (1.4); 3.4613 (1.3); 3.3801 (1.0); 3.3622 (1.0); 3.3594 (1.2); 3.3567 (1.1); 3.3388 (1.0); 3.0772 (1.6); 3.0562 (1.3); 3.0341 (3.0); 3.0131 (2.8); 2.9627 (3.0); 2.9391 (2.8); 2.9196 (1.5); 2.8960 (1.3); 2.0944 (0.8); 1.3310 (0.8); 1.2873 (7.6); 1.2832 (1.8); 1.2693 (16.0); 1.2573 (1.9); 1.2512 (7.7); 1.2395 (1.4); 1.2215 (0.6); 0.0079 (0.6); -0.0002 (17.8); -0.0085 (0.7). I.2-113: N-{[2-(Cyclobutyloxy)pyridin-4-yl]methyl}-1-(3,5-difluorphen yl)-3-methyl-5-oxopyrrolidin-3- carboxamid Eine Mischung aus 29.8 g (0.230 mol) 3,5-Difluoranilin and 30.0 g (0.230 mol) Itaconsäure wurden zusammen bei 130 °C für 1 h erhitzt. Nach Beendigung der Reaktion wurde bei ca.70 °C mit MTBE (70 mL) versetzt und auf Raumtemperatur abgekühlt. Anschließend wurde mit 400 mL Hexan versetzt und weitere 12 h gerührt, der Feststoff abfiltriert, mit Hexan gewaschen und im Vakuum bei 40 °C getrocknet. Man erhielt 49.0 g (88 % der Theorie) der 1-(3,5-Difluorphenyl)-5-oxopyrrolidin-3- carbonsäure als braunen Feststoff.49.0 g (0.203 mol) der oben erhaltenen 1-(3,5-Difluorphenyl)-5- oxopyrrolidin-3-carbonsäure wurden in 220 mL Methanol gelöst und auf 0 °C abgekühlt. Anschließend wurde bei dieser Temperatur mit 792 mg (0.72 mL=10.0 mmol) Acetylchlorid und 21.5 g (22.0 mL = 0.203 mol) Trimethylorthoformat behandelt und danach für 1 h auf 64 °C erhitzt. Danach wurde die Reaktionsmischung im Vakuum eingedampft und der Rückstand in 750 mL Dichlormethan gelöst. Nach Waschen mit 500 mL gesättigter wässriger Natriumhydrogencarbonatlösung und 300 mL Kochsalzlösung und Trocknen über Natriumsulfat erhielt man ein Rohprodukt, welches über Kieselgel chromatographisch gereinigt wurde. Man erhielt 33.5 g (65 % der Theorie) an Methyl-1-(3,5- difluorphenyl)-5-oxopyrrolidin-3-carboxylat als weißen Feststoff. Unter Argon wurden 38.0 g (0.149 mol) des oben erhaltenen Methyl-1-(3,5-difluorphenyl)-5-oxopyrrolidin-3-carboxylats in 300 mL trockenem DMF gelöst und bei 0 °C mit 10.7 g (0.268 mol) 60%iges Natriumhydrid und dann mit 24.71 g (0.174 mol) Methyliodid versetzt. Anschließend wurde 1 h bei 0 °C weitergerührt und auf Raumtemperatur erwärmt. Nach 16 h wurde mit 500 mL gesättigter Ammoniumchloridlösung hydrolysiert und zweimal mit je 500 mL MTBE extrahiert. Die vereinten organischen Phasen wurden über Natriumsulfat getrocknet, filtriert und im Vakuum eingeengt. Der Rückstand wurde in Dichlormethan gelöst und über Silicagel chromatographiert. Man erhielt 6.0 g (15 % der Theorie) an Methyl-1-(3,5-difluorphenyl)-3-methyl-5-oxopyrrolidin-3-carb oxylat als farblosen Feststoff. Eine Suspension aus 6.30 g (0.023 mol) oben erhaltenem Methyl-1-(3,5-difluorphenyl)-3-methyl-5- oxopyrrolidin-3-carboxylat in 50 mL Methanol und 50 mL Wasser wurde mit 9.8 g (0.230 mol) Lithiumhydroxid bei Raumtemperatur versetzt und zunächst bei Raumtemperatur und dann 1 h bei 80 °C erhitzt. Nach beendeter Reaktion wurde abgekühlt und das Solvens im Vakuum abgedampft. Der Rückstand wurde mit 100 mL Wasser aufgenommen und zweimal mit je 150 mL MTBE gewaschen. Danach wurde der pH der verbleibenden wässrigen Phase mit 2N Salzsäure auf 3-4 eingestellt und die wässrige Phase zweimal mit je 500 mL Ethylacetat extrahiert. Nach Trocknen der vereinten Essigesterphasen wurde filtriert und das Solvens im Vakuum entfernt. Der feste Rückstand wurde in 100 mL Hexan suspendiert (5 h), abfiltiert, mit Hexan gewaschen und im Vakuum getrocknet. Man erhielt 5.20 g (Reinheit 98 %, 87 % der Theorie) der gewünschten 1-(3,5-Difluorphenyl)-3-methyl-5- oxopyrrolidin-3-carbonsäure als farblosen Feststoff. 1 H-NMR (400.0 MHz, d1-Chlorform): δ = 1.57 (s, 3H), 2.59 (d, J = 17.3 Hz, 1H) 3.19 (br d, J = 17.3 Hz, 1H), 3.62 (d, J = 9.9 Hz, 1H), 4.36 (d, J = 10.0 Hz, 1H), 6.58 – 6.68 (m, 1H), 7.18 – 7.25 (m, 2H). Unter Stickstoff wurden 80 mg (0.31 mmol) 1-(3,5- Difluorphenyl)-3-methyl-5-oxopyrrolidin-3-carbonsäure in 4 mL trockenem THF vorgelegt, dann nacheinander mit 42.4 mg (0.31 mmol) HOBT in 1 ml THF, 61.5 mg (0.34 mmol) 1-[2- (Cyclobutyloxy)pyridin-4-yl]methanamin, 121.5 mg (0.94 mmol) Ethyldiisopropylamin und zuletzt mit 78.1 mg (0.40 mmol) EDCl in 5 mL THF versetzt und 12 h bei Raumtemperatur gerührt. Anschließend wurde die Lösung eingedampft, das Rohprodukt in 2.5 mL Dichlormethan aufgenommen und direkt über Kieselgel gereinigt. Nach Reinigung über Kieselgel wurden 126.0 mg (Reinheit 98 %, 95 % der Theorie) an N-{[2-(Cyclobutyloxy)pyridin-4-yl]methyl}-1-(3,5-difluorphen yl)-3-methyl-5-oxo- pyrrolidin-3-carboxamid als halbfestes Produkt erhalten. 1 H-NMR(400.0 MHz, CDCl3): δ 8.0973 (12.5); 8.0960 (12.3); 8.0842 (12.7); 8.0828 (12.6); 7.5183 (4.9); 7.3089 (1.2); 7.2928 (1.5); 7.2740 (4.6); 7.2595 (874.7); 7.2537 (9.4); 7.2529 (8.3); 7.2505 (3.4); 7.2488 (2.2); 7.2481 (2.3); 7.2433 (5.3); 7.2393 (13.8); 7.2336 (11.8); 7.2281 (2.2); 7.2219 (1.8); 7.2147 (1.0); 7.2092 (1.9); 6.9955 (4.7); 6.7332 (7.8); 6.7295 (8.2); 6.7200 (7.7); 6.7164 (7.9); 6.6424 (3.0); 6.6367 (5.4); 6.6309 (2.6); 6.6205 (6.0); 6.6148 (10.7); 6.6091 (5.3); 6.5986 (3.2); 6.5929 (5.4); 6.5872 (2.7); 6.5502 (11.3); 6.5486 (14.6); 6.5467 (14.2); 5.9792 (2.9); 5.2140 (1.5); 5.1943 (5.5); 5.1770 (7.3); 5.1747 (7.4); 5.1573 (5.5); 5.1399 (1.4); 4.4931 (0.8); 4.4778 (0.9); 4.4540 (10.0); 4.4478 (10.1); 4.4395 (9.8); 4.4331 (9.5); 4.4092 (0.7); 4.3951 (0.8); 4.3314 (12.6); 4.3070 (13.5); 4.1476 (0.9); 4.1296 (2.2); 4.1118 (2.2); 4.0939 (0.6); 3.5695 (14.8); 3.5451 (13.8); 3.1458 (12.1); 3.1040 (14.0); 2.5520 (16.0); 2.5102 (13.9); 2.4891 (2.7); 2.4823 (3.8); 2.4753 (2.9); 2.4715 (3.2); 2.4690 (4.1); 2.4650 (6.2); 2.4622 (5.4); 2.4584 (6.4); 2.4517 (6.5); 2.4449 (6.5); 2.4412 (5.6); 2.4382 (6.8); 2.4344 (4.5); 2.4318 (4.0); 2.4280 (3.4); 2.4209 (4.4); 2.4144 (3.3); 2.1733 (1.7); 2.1663 (1.4); 2.1526 (3.1); 2.1477 (6.7); 2.1409 (4.5); 2.1330 (2.4); 2.1283 (6.8); 2.1236 (6.6); 2.1217 (6.8); 2.1170 (5.7); 2.1043 (4.8); 2.0973 (6.0); 2.0928 (2.9); 2.0796 (1.9); 2.0734 (1.7); 2.0425 (10.5); 1.8742 (1.6); 1.8468 (4.1); 1.8442 (3.2); 1.8250 (2.4); 1.8222 (4.1); 1.8196 (3.4); 1.7973 (1.5); 1.7949 (1.6); 1.7306 (1.8); 1.7104 (3.3); 1.7058 (2.8); 1.6901 (2.1); 1.6850 (6.1); 1.6784 (2.5); 1.6627 (2.6); 1.6576 (4.9); 1.6524 (1.6); 1.6381 (2.3); 1.6322 (2.4); 1.6120 (1.5); 1.5468 (74.1); 1.3324 (0.9); 1.2838 (1.3); 1.2760 (3.6); 1.2581 (8.4); 1.2402 (3.2); 0.8802 (0.8); 0.1569 (0.7); 0.1462 (0.9); 0.0079 (9.9); -0.0002 (333.0); -0.0085 (9.4); -0.0503 (0.8); -0.1499 (0.9). I.2-116: N-[(2-Chlorpyrimidin-4-yl)methyl]-1-(3,5-dichlorphenyl)-3-me thyl-5-oxopyrrolidin-3- carboxamid Zu einer Lösung aus 240.0 g (1.63 mol) 4-Methylpyrimidin-2(1H)-on Hydrochlorid in 500 mL Eisessig und 700 mL Dioxan gab man portionsweise 160.0 g (2.45 mol) Natriumnitrit. Danach wurde die Reaktionsmischung 3h bei Raumtemperatur gerührt. Man filtrierte den gebildeten Rückstand ab, wusch mit Wasser und trocknete. Man erhält 220.0 g (97% der Theorie) 4-[(Hydroxyimino)methyl]pyrimidin- 2(1H)-on als Isomerengemisch in Form eines gelblichen Feststoffs. MS-ESI: [M+H] + 140.0. 1 H-NMR (500.0 MHz, d6-DMSO): δ= 6.67 (1H, d, J=6.5 Hz), 7.79 (1H, s), 7.93 (2H, d, J=6.5Hz), 11.87 (1H, s, NH), 12.50 (1H, s, OH). Zu 15.0 g (108.0 mmol) des Isomerengemisches 4- [(Hydroxyimino)methyl]pyrimidin-2(1H)-on in 270 mL Dioxan gab man 30 mL POCl 3 (50.4g, 0.329 mol). Die Reaktionsmischung wurde über Nacht bei 95 °C gerührt, dann auf Raumtemperatur abgekühlt und auf 150 g Eis gegossen. Anschließend wurde mehrmals mit Ethylacetat extrahiert. Die vereinten organischen Phasen wurden mit wässriger NaHCO 3 -Lösung gewaschen (800mL), über Natriumsulfat getrocknet, filtriert und im Vakuum eingedampft. Der Rückstand wurde über Kieselgel chromatographiert (Petrolether: EtOAc = 10:1~4:1). Dieses Vorgehen wurde zehnmal wiederholt und man erhielt 97.0 g (65 % der Theorie) 2-Chlorpyrimidin-4-carbonitril als gelblichen Feststoff. MS-ESI: [M+H] + 140.2. 1 H-NMR (500.0 MHz, d 6 -DMSO): δ= 8.90 (1H, d, J=5.0 Hz), 7.64 (2H, d, J=5.0 Hz). 75.0 g (540 mmol) 2-Chlorpyrimidin-4-carbonitril in 1500 mL Ethanol wurden mit 30.0 g 10% Pd/C in conc. HCl (25 mL) über einen Luftballon bei Raumtemperatur über Nacht hydriert. Nach Beendigung der Reaktion wurde vom Ungelösten abfiltriert, mit Ethanol nachgewaschen und im Vakuum eingedampft. Der Rückstand wurde in 1000 mL Dichlormethan suspendiert und bei 0 °C zuerst mit 80 mL (58.4 g, 0.577 mol) Triethylamin und dann mit 118.0 g (540.0 mmol) Di-tert-butyldicarbonat versetzt. Anschließend wurde noch 2 h bei Raumtemperatur nachgerührt und schließlich mit 200 mL Wasser gequencht. Die organische Phase wurde abgetrennt und im Vakuum eingedampft. Nach Chromatographie über Kieselgel (Petrolether: EtOAc = 10:1~6:1) erhielt man 67.5g (51.4 % der Theorie) tert-Butyl-[(2-chlorpyrimidin-4-yl)methyl]carbamat als weißen Feststoff.7.00 g (28.8 mmol) tert-Butyl-[(2-chlorpyrimidin-4-yl)methyl]carbamat in Essigsäureethylester (50 mL) wurden mit 20.0 mL Salzsäure (4M in Dioxan) versetzt und über Nacht bei Raumtemperatur gerührt. Nach Entfernen der Lösungsmittels im Vakuum erhielt man 5.00 g (96 % der Theorie) an 1-(2-Chlorpyrimidin-4- yl)methanamin Hydrochlorid als rosa Feststoff. MS-ESI: [M+H] + 144. DMSO): δ= 8.84 (d, J = 5.0 Hz, 4H), 7.76 (d, J = 5.0 Hz, 1H), 4.28-4.24 (m, 2H). Eine Mischung aus 24.9 g (0.154 mol) 3,5-Dichloranilin and 20.0 g (0.154 mol) Itaconsäure wurden zusammen bei 150 °C für 1 h erhitzt. Nach Beendigung der Reaktion wurde auf Raumtemperatur abgekühlt, mit Hexan (500 mL) versetzt und weitere 16 h gerührt. Der Feststoff wurde abfiltriert, mit Hexan gewaschen und im Vakuum bei 40 °C getrocknet. Man erhielt 30.0 g (71 % der Theorie) der 1-(3,5-Dichlorphenyl)-5- oxopyrrolidin-3-carbonsäure als braunen Feststoff. 30.0 g (0.109 mol) der oben erhaltenen 1-(3,5- Dichlorphenyl)-5-oxopyrrolidin-3-carbonsäure wurden in 120 mL Methanol gelöst und auf 0 °C abgekühlt. Anschließend wurde bei dieser Temperatur mit 471 mg (0.4 mL =6.0 mmol) Acetylchlorid und 11.6 g (12.0 mL =109 mmol) Trimethylorthoformat behandelt und danach für 1 h auf 64 °C erhitzt. Anschließend wurde die Reaktionsmischung im Vakuum eingedampft und der Rückstand in 750 mL Dichlormethan gelöst. Nach Waschen mit 500 mL gesättigter wässriger Natriumhydrogencarbonat- lösung und 300 mL Kochsalzlösung und Trocknen über Natriumsulfat erhielt man ein Rohprodukt, welches über Kieselgel chromatographisch gereinigt wurde. Man erhielt 20.0 g (64 % der Theorie) an Methyl-1-(3,5-dichlorphenyl)-5-oxopyrrolidin-3-carboxylat als weißen Feststoff. Unter Argon wurden 20.0 g (0.069 mol) des oben erhaltenen Methyl-1-(3,5-dichlorphenyl)-5-oxopyrrolidin-3-carboxylats in 300 mL trockenem DMF gelöst. Zu dieser Lösung gab man über einen Zeitraum von 20 min 3.30 g (0.083 mol) 60%iges Natriumhydrid und anschließend bei 0 °C 24.71 g (0.174 mol) Methyliodid. Anschließend wurde auf 10 °C erwärmt und 3 h bei dieser Temperatur gerührt. Nach beendeter Reaktion wurde mit 300 mL gesättigter Ammoniumchloridlösung hydrolysiert und zweimal mit je 500 mL MTBE extrahiert. Die vereinten organischen Phasen wurden über Natriumsulfat getrocknet, filtriert und im Vakuum eingeengt. Der Rückstand wurde in Dichlormethan gelöst und über Silicagel chromatographiert. Man erhielt 7.50 g (36 % der Theorie) an Methyl-1-(3,5-dichlorphenyl)-3-methyl-5- oxopyrrolidin-3-carboxylat als grünliches Öl. Eine Suspension aus 7.50 g (0.025 mol) oben erhaltenem Methyl-1-(3,5-dichlorphenyl)-3-methyl-5-oxopyrrolidin-3-carb oxylat in 40 mL Methanol und 40 mL Wasser wurde mit 10.4 g (0.248 mol) Lithiumhydroxid bei Raumtemperatur versetzt und zunächst bei Raumtemperatur und dann 1 h bei 80 °C erhitzt. Nach beendeter Reaktion wurde abgekühlt und das Solvens im Vakuum abgedampft. Der Rückstand wurde mit 100 mL Wasser aufgenommen und zweimal mit je 150 mL MTBE gewaschen. Danach wurde der pH der verbleibenden wässrigen Phase mit 2N Salzsäure auf 3-4 eingestellt und die wässrige Phase zweimal mit je 500 mL Ethylacetat extrahiert. Nach Trocknen der vereinten Essigesterphasen über Natriumsulfat wurde filtriert und das Solvens im Vakuum entfernt. Der Rückstand wurde in 50 mL Hexan suspendiert (5 h), abfiltiert und mit Hexan gewaschen. Man erhielt 5.40 g (Reinheit 98 %, 76% der Theorie) der gewünschten 1-(3,5- Dichlorphenyl)-3-methyl-5-oxopyrrolidin-3-carbonsäure als farblosen Feststoff. 1 H-NMR (400.0 MHz, d 1 -Chlorform): δ= 1.55 (s, 3H), 2.57 (d, J=17.33 Hz, 1H), 3.17 (d, J=17.33 Hz, 1H), 3.62 (d, J=10.01 Hz, 1H), 4.26 (d, J=10.01 Hz, 1H), 7.15 (d, J=1.75 Hz, 1H) 7.56 (t, J=1.83 Hz, 2H). Unter Stickstoff wurden 80 mg (0.27 mmol) 1-(3,5-Dichlorphenyl)-3-methyl-5-oxopyrrolidin-3-carbonsäur e in 4 mL trockenem THF vorgelegt, dann nacheinander mit 37.5 mg (0.27 mmol) HOBT in 1 ml THF, 55.5 mg (0.30 mmol) 1-(2-Chlorpyrimidin-4-yl)methanamin Hydrochlorid, 143.5 mg (1.11 mmol) Ethyldiisopropylamin und zuletzt mit 69.2 mg (0.36 mmol) EDCl in 5 mL THF versetzt und 12 h bei Raumtemperatur gerührt. Anschließend wurde die Lösung eingedampft, mit Dichlormethan aufgenommen und mit Phosphatpuffer (pH5.5) gewaschen. Nach Trocknen über Natriumsulfat und Entfernen des Lösungsmittels im Vakuum wurde das Produkt in Dichlormethan aufgenommen und über Kieselgel chromatographiert. Nach Reinigung über Kieselgel wurden 50 mg (Reinheit 97 %, 42% der Theorie) des Produktes N-[(2-Chlorpyrimidin-4-yl)methyl]-1-(3,5-dichlorphenyl)-3-me thyl-5- oxopyrrolidin-3-carboxamid als ein orangefarbener, halbfester Feststoff erhalten. 1 H-NMR (400.6 MHz, CDCl3): δ 8.6053 (7.4); 8.5926 (7.5); 7.5987 (15.7); 7.5942 (16.0); 7.5197 (1.8); 7.2855 (1.4); 7.2613 (327.8); 7.2538 (1.6); 7.2522 (1.3); 7.2482 (5.3); 7.2355 (4.5); 7.2341 (2.6); 7.1599 (4.0); 7.1554 (7.6); 7.1509 (3.8); 6.9976 (1.8); 6.7821 (1.0); 4.5968 (3.9); 4.5923 (3.8); 4.5911 (3.8); 4.5836 (3.8); 4.5792 (3.7); 4.3219 (3.9); 4.2975 (4.1); 4.1308 (1.0); 4.1130 (1.0); 3.6004 (4.5); 3.5760 (4.1); 3.1870 (3.8); 3.1449 (4.3); 2.5936 (4.9); 2.5515 (4.2); 2.1367 (4.8); 2.1007 (5.3); 2.0456 (4.9); 1.5900 (21.5); 1.5608 (35.5); 1.4400 (2.4); 1.4258 (2.3); 1.3324 (0.9); 1.2843 (1.4); 1.2775 (1.7); 1.2597 (4.0); 1.2419 (1.6); 0.0080 (3.6); -0.0002 (108.9); -0.0085 (3.2). I.2-121: N-Benzyl-6-(3,5-dichlorphenyl)-N,2,4-trimethyl-7-oxo-6-azabi cyclo[3.2.1]oct-3-en-8- carboxamid Unter Stickstoff wurden 51.0 mg (0.15 mmol) 6-(3,5-Dichlorphenyl)-2,4-dimethyl-7-oxo-6- azabicyclo[3.2.1]oct-3-en-8-carbonsäure in 2 mL trockenem Dichlormethan vorgelegt, dann nacheinander mit 20.3 mg (0.15 mmol) HOBT in 0.5 mL Dichlormethan, 20.0 mg (0.17 mmol) N- Methyl-1-phenylmethanamin, 58.2 mg (0.45 mmol) Ethyldiisopropylamin und zuletzt mit 37.4 mg (0.2 mmol) EDCl versetzt und 12 h bei Raumtemperatur gerührt. Anschließend wurde die Lösung filtriert, zweimal mit Wasser gewaschen, die organische Phase getrocknet und einrotiert. Nach Reinigung über eine präparative HPLC wurden 35.7 mg (Reinheit 97%, 52% der Theorie) des Produktes N-Benzyl-6- (3,5-dichlorphenyl)-N,2,4-trimethyl-7-oxo-6-azabicyclo[3.2.1 ]oct-3-en-8-carboxamid erhalten. 1 H-NMR (400.0 MHz, CDCl 3 ): δ 7.5915 (6.1); 7.5870 (6.3); 7.5502 (2.8); 7.5458 (2.8); 7.4354 (0.5); 7.4181 (1.4); 7.3994 (1.2); 7.3766 (0.7); 7.3588 (0.7); 7.2960 (0.6); 7.2921 (0.7); 7.2840 (2.2); 7.2770 (1.7); 7.2699 (4.4); 7.2659 (5.0); 7.2600 (54.5); 7.1812 (3.3); 7.1740 (2.2); 7.1668 (2.4); 7.1627 (2.5); 7.1197 (1.7); 7.1152 (3.0); 7.1107 (1.6); 7.0874 (0.8); 7.0831 (1.3); 7.0787 (0.7); 5.3549 (1.5); 5.3518 (1.5); 5.2782 (0.8); 4.8428 (1.6); 4.8064 (1.8); 4.6588 (0.5); 4.6172 (1.0); 4.5208 (1.0); 4.4792 (0.5); 4.3726 (2.4); 4.3352 (2.0); 4.2988 (1.7); 4.2651 (1.2); 3.4891 (7.9); 3.2234 (3.7); 3.1902 (1.7); 2.9895 (1.4); 2.9771 (1.5); 2.9582 (7.8); 2.9517 (16.0); 2.9361 (0.9); 2.7593 (0.5); 2.7535 (0.6); 2.7472 (0.6); 2.7413 (0.5); 1.8643 (4.3); 1.8593 (6.1); 1.8545 (4.4); 1.7465 (2.3); 1.7420 (3.2); 1.7373 (2.2); 1.6370 (1.2); 1.2090 (6.1); 1.1909 (6.0); 1.1487 (3.0); 1.1305 (2.9); 0.0080 (0.7); -0.0002 (21.6); -0.0085 (0.6). I.2-142: 1-(3-Chlor-5-methylphenyl)-N-[(2-chlorpyridin-4-yl)methyl]-3 -methyl-5-oxopyrrolidin-3- carboxamid Eine Mischung aus 18.5 g (0.131 mol) 3-Chlor-5-methylanilin and 17.0 g (0.131 mol) Itaconsäure wurden zusammen bei 130 °C für 1 h erhitzt. Nach Beendigung der Reaktion wurde bei ca.70 °C mit MTBE (50 mL) versetzt und auf Raumtemperatur abgekühlt. Anschließend wurde mit 400 mL Hexan versetzt und weitere 2 h gerührt, der Feststoff abfiltriert, mit Hexan (100 mL) gewaschen und im Vakuum bei 40 °C getrocknet. Man erhielt 30.0 g (91 % der Theorie) der 1-(3-Chlor-5-methylphenyl)-5- oxopyrrolidin-3-carbonsäure als braunen Feststoff.31.0 g (0.122 mol) der oben erhaltenen 1-(3-Chlor-5- methylphenyl)-5-oxopyrrolidin-3-carbonsäure wurden in 150 mL Methanol gelöst und auf 0 °C abgekühlt. Anschließend wurde bei dieser Temperatur mit 471.0 mg (0.43 mL =6.0 mmol) Acetylchlorid und 12.96 g (13.3 mL = 0.122 mol) Trimethylorthoformat behandelt und danach für 1 h auf 64 °C erhitzt. Anschließend wurde die Reaktionsmischung im Vakuum eingedampft und der Rückstand in 750 mL Dichlormethan gelöst. Nach Waschen mit 500 mL gesättigter wässriger Natriumhydrogencarbonatlösung und 300 mL Kochsalzlösung und Trocknen über Natriumsulfat erhielt man ein Rohprodukt, welches über Kieselgel chromatographisch gereinigt wurde. Man erhielt 28.0 g (86 % der Theorie) an Methyl-1-(3-chlor-5-methylphenyl)-5-oxopyrrolidin-3-carboxyl at als weißen Feststoff. Unter Argon wurden 23.0 g (0.086 mol) des oben erhaltenen Methyl-1-(3-chlor-5- methylphenyl)-3-methyl-5-oxopyrrolidin-3-carboxylats in 250 mL trockenem DMF gelöst und bei 0 °C mit 4.50 g (0.122 mol) 60%iges Natriumhydrid und dann mit 36.62 g (0.258 mol) Methyliodid versetzt. Anschließend wurde 1 h bei 0 °C weitergerührt und auf Raumtemperatur erwärmt. Nach 16 h wurde mit 300 mL gesättigter Ammoniumchloridlösung hydrolysiert und zweimal mit je 300 mL MTBE extrahiert. Die vereinten organischen Phasen wurden über Natriumsulfat getrocknet, filtriert und im Vakuum eingeengt. Der Rückstand wurde in Dichlormethan gelöst und über Silicagel chromatographiert. Man erhielt 8.0 g (33 % der Theorie) an Methyl-1-(3-chlor-5-methylphenyl)-3-methyl-5-oxopyrrolidin-3 - carboxylat als grünliches Öl. Eine Suspension aus 8.90 g (0.028 mol) oben erhaltenem Methyl-1-(3- chlor-5-methylphenyl)-3-methyl-5-oxopyrrolidin-3-carboxylats in 50 mL Methanol und 50 mL Wasser wurde mit 11.9 g (0.283 mol) Lithiumhydroxid bei Raumtemperatur versetzt und zunächst bei Raumtemperatur und dann 1 h bei 80 °C erhitzt. Nach beendeter Reaktion wurde abgekühlt und das Solvens im Vakuum abgedampft. Der Rückstand wurde mit 100 mL Wasser aufgenommen und zweimal mit je 100 mL MTBE gewaschen. Danach wurde der pH der verbleibenden wässrigen Phase mit 2N Salzsäure auf 3-4 eingestellt und die wässrige Phase dreimal mit je 500 mL Ethylacetat extrahiert. Nach Trocknen der vereinten Essigesterphasen wurde filtriert und das Solvens im Vakuum entfernt. Der feste Rückstand wurde in 250 mL Hexan suspendiert (5 h), abfiltiert und mit Hexan gewaschen. Nach Trocknen bei 40 °C erhielt man 6.50 g (Reinheit 96.5 %, 86 % der Theorie) der gewünschten 1-(3-Chlor-5-methylphenyl)-3-methyl-5-oxopyrrolidin-3-carbon säure als farblosen Feststoff. 1 H-NMR (400.0 MHz, d1-Chlorform): δ = 2.34 (s, 3 H) 2.56 (d, J=17.33 Hz, 1 H) 3.17 (d, J=17.33 Hz, 1 H) 3.63 (d, J=10.01 Hz, 1 H) 4.27 (d, J=10.01 Hz, 1 H) 6.99 (br s, 1 H) 7.32 (br s, 1 H) 7.41 (br s, 1 H). Unter Stickstoff wurden 70 mg (0.26 mmol) 1-(3-Chlor-5-methylphenyl)-3-methyl-5- oxopyrrolidin-3-carbonsäure in 4 mL trockenem THF vorgelegt, dann nacheinander mit 35.3 mg (0.26 mmol) HOBT in 1 ml THF, 61.5 mg (0.34 mmol) 2-Chlorpyridin-4-yl)methanaminiumchlorid, 135.2 mg (1.04 mmol) Ethyldiisopropylamin und zuletzt mit 65.2 mg (0.34 mmol) EDCl in 5 mL THF versetzt und 12 h bei Raumtemperatur gerührt. Anschließend wurde die Lösung eingedampft, das Rohprodukt in 2.5 mL Dichlormethan aufgenommen und direkt über Kieselgel gereinigt. Nach Reinigung über Kieselgel wurden 99.0 mg (Reinheit 91 %, 88 % der Theorie) an 1-(3-Chlor-5-methylphenyl)-N-[(2- chlorpyridin-4-yl)methyl]-3-methyl-5-oxopyrrolidin-3-carboxa mid als gelbes Harz erhalten. 1 H- NMR(400.0 MHz, CDCl3): δ 8.3342 (2.9); 8.3215 (2.9); 7.4361 (1.8); 7.4323 (3.2); 7.4276 (1.9); 7.2872 (2.9); 7.2628 (37.6); 7.1940 (3.5); 7.1924 (3.5); 7.1048 (2.0); 7.1031 (1.8); 7.1012 (1.9); 7.0920 (1.9); 7.0885 (1.8); 6.9815 (3.0); 6.3794 (0.8); 4.4895 (2.2); 4.4756 (3.7); 4.4614 (2.1); 4.3291 (3.1); 4.3044 (3.3); 4.1440 (0.9); 4.1262 (2.6); 4.1083 (2.7); 4.0904 (0.9); 3.5933 (3.6); 3.5686 (3.4); 3.0964 (2.9); 3.0547 (3.3); 2.9516 (0.9); 2.8673 (0.8); 2.5411 (3.7); 2.4994 (3.2); 2.3330 (16.0); 2.3320 (15.8); 2.0412 (12.3); 1.5458 (16.6); 1.2815 (0.5); 1.2752 (3.6); 1.2573 (8.0); 1.2395 (3.5); -0.0002 (13.4) I.3-4: 2-(2,5-Dimethylphenyl)-N-[1-(chinolin-8-yl)-5-oxopyrrolidin- 3-yl]acetamid. Itaconsäure (100 mmol, 1 Äquiv.) und 8-Aminochinolin (100 mmol, 1 Äquiv.) wurden zusammen in einen ausgeheizten Rundkolben gegeben und 16 h lang bei bei einer Temperatur von 150 °C gerührt. Nach dem Abkühlen auf Raumtemperatur wurde das Reaktionsgemisch unter vermindertem Druck eingeengt Durch Umkristallisieren aus Essigester wurde 1-(2-Fluorphenyl)-5-oxopyrrolidin-3- carbonsäure in Form eines farblosen Feststoffs erhalten und ohne weitere Reinigung im nächsten Reaktionsschritt eingesetzt.1-(Chinolin-8-yl)-5-oxopyrrolidin-3-carbonsäure (48.8 mmol, 1 Äquiv.) wurde in tert. Butanol (100 mL) gelöst und mit Diphenylphosphorylazid (58.8 mmol, 1.2 Äquiv.) und Triethylamin (146.4 mmol, 3.0 Äquiv.) versetzt. Das resultierende Reaktionsgemisch wurde 2 h lang bei 80 °C gerührt, nach dem Abkühlen auf Raumtemperatur unter vermindertem Druck eingeengt und das erhaltene Rohprodukt ohne weitere Reinigung in einem Gemisch aus Salzsäure und Essigester (100 mL) aufgenommen und 16 h lang bei Raumtemperatur gerührt. Der ausgefallene Feststoff wurde abfiltriert und getrocknet. Auf diese Weise konnte 4-Amino-1-(chinolin-8-yl)pyrrolidin-2-on als Hydrochloridsalz in Form eines farblosen Feststoffs erhalten werden.4-Amino-1-(chinolin-8-yl)pyrrolidin-2-on Hydrochloridsalz (150 mg, 0.57 mmol) wurde in einem ausgeheizten Rundkolben in abs. Dichlormethan (5 mL) gelöst und mit Triethylamin (0.19 mL, 1.42 mmol) versetzt. Nach 10 Minuten Rühren bei Raumtemperatur erfolgte die Zugabe von 2,5-Dimethylphenylessigsäurechlorid (114 mg, 0.63 mmol). Das resultierende Reaktionsgemisch wurde 2 h bei Raumtemperatur gerührt, mit Wasser und Dichlormethan versetzt und gründlich extrahiert. Die vereinigten organischen Phasen würden über Magnesiumsulfat getrocknet, abfiltriert und unter vermindertem Druck eingeeingt. Durch säulenchromatographische Reinigung (Gradient Essigester/Heptan) des erhaltenen Rohproduktes wurde 2-(2,5-Dimethylphenyl)-N-[1-(chinolin-8-yl)-5-oxopyrrolidin- 3-yl]acetamid (189 mg, 89% der Theorie) in Form eines farblosen Feststoffs erhalten. 1 H-NMR (400 MHz, d6-DMSO) δ ppm 8.91 (m, 1H), 8.64 (br. d, 1H, NH), 8.46 (dd, 1H), 7.99 (m, 1H), 7.75 (d, 1H), 7.66 (dd, 1H), 7.60 (dd, 1H), 7.04-6.98 (m, 2H), 6.92 (m, 1H), 4.59-4.53 (m, 1H), 4.31-4.27 (dd, 1H), 3.80-3.76 (dd, 1H), 3.46 (s, 2H), 2.93-2.88 (dd, 1H), 2.46-2.39 (dd, 1H), 2.22 (s, 3H). I.3-13: 2-(2,5-Dichlorphenyl)-N-[1-(2-fluorphenyl)-5-oxopyrrolidin-3 -yl]acetamid. Itaconsäure (100 mmol, 1 Äquiv.) und 2-Fluoranilin (100 mmol, 1 Äquiv.) wurden zusammen in einen ausgeheizten Rundkolben gegeben und 16 h lang bei bei einer Temperatur von 150 °C gerührt. Nach dem Abkühlen auf Raumtemperatur wurde das Reaktionsgemisch unter vermindertem Druck eingeengt Durch Umkristallisieren aus Essigester wurde 1-(2-Fluorphenyl)-5-oxopyrrolidin-3-carbonsäure in Form eines farblosen Feststoffs erhalten und ohne weitere Reinigung im nächsten Reaktionsschritt eingesetzt. 1-(2-Fluorphenyl)-5-oxopyrrolidin-3-carbonsäure (48.8 mmol, 1 Äquiv.) wurde in tert. Butanol (100 mL) gelöst und mit Diphenylphosphorylazid (58.8 mmol, 1.2 Äquiv.) und Triethylamin (146.4 mmol, 3.0 Äquiv.) versetzt. Das resultierende Reaktionsgemisch wurde 2 h lang bei 80 °C gerührt, nach dem Abkühlen auf Raumtemperatur unter vermindertem Druck eingeengt und das erhaltene Rohprodukt ohne weitere Reinigung in einem Gemisch aus Salzsäure und Essigester (100 mL) aufgenommen und 16 h lang bei Raumtemperatur gerührt. Der ausgefallene Feststoff wurde abfiltriert und getrocknet. Auf diese Weise konnte 4-Amino-1-(2-fluorphenyl)pyrrolidin-2-on in Form eines farblosen Feststoffs erhalten werden.4-Amino-1-(2-fluorphenyl)pyrrolidin-2-on (150 mg, 0.65 mmol) wurde in einem ausgeheizten Rundkolben in abs. Dichlormethan (5 mL) gelöst und mit Triethylamin (0.23 mL, 1.63 mmol) versetzt. Nach 10 Minuten Rühren bei Raumtemperatur erfolgte die Zugabe von 2,5- Dichlorphenylessigsäurechlorid (160 mg, 0.72 mmol). Das resultierende Reaktionsgemisch wurde 2 h bei Raumtemperatur gerührt, mit Wasser und Dichlormethan versetzt und gründlich extrahiert. Die vereinigten organischen Phasen würden über Magnesiumsulfat getrocknet, abfiltriert und unter vermindertem Druck eingeeingt. Durch säulenchromatographische Reinigung (Gradient Essigester/Heptan) des erhaltenen Rohproduktes wurde 2-(2,5-Dichlorphenyl)-N-[1-(2-fluorphenyl)-5- oxopyrrolidin-3-yl]acetamid (93 mg, 38% der Theorie) in Form eines farblosen Feststoffs erhalten. 1 H- NMR (400 MHz, CDCl 3 ) δ ppm 7.38-7.30 (m, 3H), 7.28-7.08 (m, 4H), 5.91-5.84 (br. m, 1H, NH), 4.75- 4.67 (m, 1H), 4.14-4.10 (m, 1H), 3.69-3.63 (m, 3H), 2.98-2.92 (dd, 1H), 2.45-2.39 (dd, 1H). I.3-14: 2-(2,5-Dichlorphenyl)-N-[1-(chinolin-8-yl)-5-oxopyrrolidin-3 -yl]acetamid. 4-Amino-1-(chinolin-8-yl)pyrrolidin-2-on Hydrochloridsalz (150 mg, 0.57 mmol) wurde in einem ausgeheizten Rundkolben in abs. Dichlormethan (5 mL) gelöst und mit Triethylamin (0.19 mL, 1.42 mmol) versetzt. Nach 10 Minuten Rühren bei Raumtemperatur erfolgte die Zugabe von 2,5- Dichlorphenylessigsäurechlorid (140 mg, 0.63 mmol). Das resultierende Reaktionsgemisch wurde 2 h bei Raumtemperatur gerührt, mit Wasser und Dichlormethan versetzt und gründlich extrahiert. Die vereinigten organischen Phasen würden über Magnesiumsulfat getrocknet, abfiltriert und unter vermindertem Druck eingeeingt. Durch säulenchromatographische Reinigung (Gradient Essigester/Heptan) des erhaltenen Rohproduktes wurde 2-(2,5-Dichlorphenyl)-N-[1-(chinolin-8-yl)-5- oxopyrrolidin-3-yl]acetamid (156 mg, 66% der Theorie) in Form eines farblosen Feststoffs erhalten. 1 H- NMR (400 MHz, d6-DMSO) δ ppm 8.93 (m, 1H), 8.80 (br. d, 1H, NH), 8.46 (dd, 1H), 7.99 (m, 1H), 7.75 (d, 1H), 7.67 (dd, 1H), 7.61 (dd, 1H), 7.51 (m, 1H), 7.44 (m, 1H), 7.35 (m, 1H), 4.62-4.57 (m, 1H), 4.31-4.27 (dd, 1H), 3.81-3.78 (dd, 1H), 3.67 (s, 2H), 2.94-2.88 (dd, 1H), 2.49-2.43 (dd, 1H). I.3-19: 2-(2,5-Dichlorphenyl)-N-[1-cyclopropyl-5-oxopyrrolidin-3-yl] acetamid. Itaconsäure (100 mmol, 1 Äquiv.) und Cyclopropylamin (100 mmol, 1 Äquiv.) wurden zusammen in einen ausgeheizten Rundkolben gegeben und 16 h lang bei bei einer Temperatur von 150 °C gerührt. Nach dem Abkühlen auf Raumtemperatur wurde das Reaktionsgemisch unter vermindertem Druck eingeengt Durch Umkristallisieren aus Essigester wurde 1-Cyclopropyl-5-oxopyrrolidin-3-carbonsäure in Form eines farblosen Feststoffs erhalten und ohne weitere Reinigung im nächsten Reaktionsschritt eingesetzt.1-Cyclopropyl-5-oxopyrrolidin-3-carbonsäure (48.8 mmol, 1 Äquiv.) wurde in tert. Butanol (100 mL) gelöst und mit Diphenylphosphorylazid (58.8 mmol, 1.2 Äquiv.) und Triethylamin (146.4 mmol, 3.0 Äquiv.) versetzt. Das resultierende Reaktionsgemisch wurde 2 h lang bei 80 °C gerührt, nach dem Abkühlen auf Raumtemperatur unter vermindertem Druck eingeengt und das erhaltene Rohprodukt ohne weitere Reinigung in einem Gemisch aus Salzsäure und Essigester (100 mL) aufgenommen und 16 h lang bei Raumtemperatur gerührt. Der ausgefallene Feststoff wurde abfiltriert und getrocknet. Auf diese Weise konnte 4-Amino-1-cyclopropylpyrrolidin-2-on als Hydrochloridsalz in Form eines farblosen Feststoffs erhalten werden.4-Amino-1-cyclopropyl-pyrrolidin-2-on Hydrochloridsalz (150 mg, 0.85 mmol) wurde in einem ausgeheizten Rundkolben in abs. Dichlormethan (5 mL) gelöst und mit Triethylamin (0.30 mL, 2.12 mmol) versetzt. Nach 10 Minuten Rühren bei Raumtemperatur erfolgte die Zugabe von 2,5-Dichlorphenylessigsäurechlorid (209 mg, 0.93 mmol). Das resultierende Reaktionsgemisch wurde 2 h bei Raumtemperatur gerührt, mit Wasser und Dichlormethan versetzt und gründlich extrahiert. Die vereinigten organischen Phasen würden über Magnesiumsulfat getrocknet, abfiltriert und unter vermindertem Druck eingeeingt. Durch säulenchromatographische Reinigung (Gradient Essigester/Heptan) des erhaltenen Rohproduktes wurde 2-(2,5-Dichlorphenyl)-N-[1- cyclopropyl-5-oxopyrrolidin-3-yl]acetamid (222 mg, 80% der Theorie) in Form eines farblosen Feststoffs erhalten. 1 H-NMR (400 MHz, CDCl3) δ ppm 7.34-7.30 (m, 2H), 7.28-7.23 (m, 1H), 5.96-5.89 (br. m, 1H, NH), 4.52-4.43 (m, 1H), 3.67-3.64 (m, 1H), 3.63 (s, 2H), 3.15-3.10 (dd, 1H), 2.78-2.72 (dd, 1H), 2.65-2.61 (m, 1H), 2.23-2.18 (dd, 1H), 0.78-0-70 (m, 2H), 0.69-0.59 (m, 2H). I.4-33: 1-(4-Chlorphenyl)-3-[4-methyl-1-phenyl-5-oxopyrrolidin-3-yl] harnstoff. N-Phenylglycinethylester (60 mmol, 1 Äquiv.) und Diisopropylethylamin (120 mmol, 2 Äquiv.) wurden zusammen in einen ausgeheizten Rundkolben gegeben, in abs. Dichlormethan gelöst (150 mL) und mit Propionylchlorid (120 mmol, 2 Äquiv.) versetzt. Das resultierende Reaktionsgemisch wurde 16 h lang bei bei Raumtemperatur gerührt und danach unter vermindertem Druck eingeengt Nach der Zugabe von gesättigter Natriumhydrogencarbonatlösung und von Essigester wurde die wässrige Phase dreimal mit Essigester extrahiert (200 mL insgesamt). Durch Trocknen der vereinigten organischen Phasen über Natriumsulfat, Abflitrieren und Einengen unter vermindertem Druck wurde N-Propionyl-N- phenylglcinethylester erhalten und ohne weitere Reinigung im nächsten Reaktionsschritt eingesetzt. N- Propionyl-N-phenylglcinethylester (60 mmol, 1.0 Äquiv.) wurde in abs. Tetrahydrofuran gelöst und vorsichtig mit Natriumhydrid (180 mmol, 3 Äquiv.) versetzt. Das resultierende Reaktionsgemisch wurde 48 h lang bei einer Temperatur von 65 °C gerührt. Nach dem Abkühlen auf Raumtemperatur wurde die Reaktionsmischung durch tropfenweise Zugabe von Ethanol gequencht und danach unter vermindertem Druck eingeengt. Durch säulenchromatographische Reinigung des verbleibenden Rückstandes (20% Petrolether/Essigester) wurde 1-Phenyl-3,5-dioxo-4-methylpyrrolidin in Form eines farblosen Feststoffs erhalten.1-Phenyl-3,5-dioxo-4-methylpyrrolidin (30.0 mmol, 1 Äquiv.) wurde in Dichlormethan (100 mL) gelöst und mit Hydroxylaminhydrochlorid (36.0 mmol, 1.2 Äquiv.) sowie Diisopropylethylamin (60 mmol, 2.0 Äquiv.) versetzt. Das resultierende Reaktionsgemisch wurde 16 h lang bei Raumtemperatur gerührt, unter vermindertem Druck eingeengt und das erhaltene Rohprodukt ohne weitere Reinigung in Methanol (100 mL) aufgenommen, mit Palladium auf Kohle (1.0 g) versetzt und 16 h lang bei Raumtemperatur under einer Wasserstoffatmosphäre (1 bar) gerührt. Danach wurde das Reaktionsgemisch über Celite filtriert und unter vermindertem Druck eingeengt. Der Rückstand wurde in Essigsäure aufgenommen (50 mL) und mit Natriumcyanoborhydrid (60 mmol, 2 Äquiv.) versetzt. Das Reaktionsgemisch wurde weitere 16 h lang bei Raumtemperatur gerührt und erneut eingeengt. Durch säulenchromatographische Reinigung des verbleibenden Rückstandes (20% Petrolether/Essigester) wurde 3-Amino-4-methyl-1-phenyl-5-oxopyrrolidin in Form eines farblosen Feststoffs erhalten.3- Amino-4-methyl-1-phenyl-5-oxopyrrolidin (1.0 mmol, 1 Äquiv.) wurde in einem ausgeheizten Rundkolben in abs. Dichlormethan (5 mL) gelöst und mit Diisopropylethylamin (2.0 mmol, 2 Äquiv.) versetzt. Nach 10 Minuten Rühren bei Raumtemperatur erfolgte die tropfenweise Zugabe einer Lösung von 4-Chlorphenylisocyanat (1.2 mmol, 1.2 Äquiv.) in abs. Dichlormethan (2 mL). Das resultierende Reaktionsgemisch wurde 16 h bei Raumtemperatur gerührt und danach unter vermindertem Druck eingeeingt. Durch präparative HPLC-Reinigung des erhaltenen Rohproduktes wurde 1-(4-Chlorphenyl)- 3-[4-methyl-1-phenyl-5-oxopyrrolidin-3-yl]harnstoff (213 mg, 62% der Theorie) in Form eines farblosen Feststoffs erhalten. 1 H-NMR (400 MHz, d6-DMSO) δ ppm 8.80 (br. s, 1H, NH), 7.69 (d, 2H), 7.47-7.38 (m, 4H), 7.30 (d, 2H), 7.17-7.13 (m, 1H), 6.76 (br. d, 1H, NH), 4.12-4.03 (m, 2H), 3.61-3.58 (m, 1H), 2.69-2.61 (m, 1H), 1.20 (d, 3H). I.4-36: 1-(5-Chlor-2-methylphenyl)-3-[1-phenyl-5-oxopyrrolidin-3-yl] harnstoff. Itaconsäure (100 mmol, 1 Äquiv.) und Anilin (100 mmol, 1 Äquiv.) wurden zusammen in einen ausgeheizten Rundkolben gegeben und 16 h lang bei bei einer Temperatur von 150 °C gerührt. Nach dem Abkühlen auf Raumtemperatur wurde das Reaktionsgemisch unter vermindertem Druck eingeengt Durch Umkristallisieren aus Essigester wurde 1-Phenyl-5-oxopyrrolidin-3-carbonsäure in Form eines farblosen Feststoffs erhalten und ohne weitere Reinigung im nächsten Reaktionsschritt eingesetzt. Phenyl-5-oxopyrrolidin-3-carbonsäure (48.8 mmol, 1 Äquiv.) wurde in tert. Butanol (100 mL) gelöst und mit Diphenylphosphorylazid (58.8 mmol, 1.2 Äquiv.) und Triethylamin (146.4 mmol, 3.0 Äquiv.) versetzt. Das resultierende Reaktionsgemisch wurde 2 h lang bei 80 °C gerührt, nach dem Abkühlen auf Raumtemperatur unter vermindertem Druck eingeengt und das erhaltene Rohprodukt ohne weitere Reinigung in einem Gemisch aus Salzsäure und Essigester (100 mL) aufgenommen und 16 h lang bei Raumtemperatur gerührt. Der ausgefallene Feststoff wurde abfiltriert und getrocknet. Auf diese Weise konnte 4-Amino-1-phenylpyrrolidin-2-on als Hydrochloridsalz in Form eines farblosen Feststoffs erhalten werden.4-Amino-1-phenylpyrrolidin-2-on Hydrochlorid (7.05 g, 33 mmol) wurde in einem ausgeheizten Rundkolben in abs. Acetonitril (20 mL) gelöst und mit Triethylamin (6.01 mL, 43.09 mmol) versetzt sowie auf 10 °C eingekühlt. Nach 10 Minuten Rühren bei einer Temperatur von 10 °C erfolgte die tropfenweise Zugabe einer Lösung von 5-Chlor-2-methylphenylisocyanat (5.00 g, 29.83 mmol). Das resultierende Reaktionsgemisch wurde 4 h bei Raumtemperatur gerührt, mit Essigester, Wasser und verd. Salzsäure versetzt und die wässrige Phase gründlich mit Essigester extrahiert. Die vereinigten organischen Phasen würden über Magnesiumsulfat getrocknet, abfiltriert und unter vermindertem Druck eingeeingt. Durch präparative HPLC-Reinigung des erhaltenen Rohproduktes wurde 1-(5-Chlor-2-methylphenyl)-3-[1-phenyl-5-oxopyrrolidin-3-yl] harnstoff (7.75 g, 68% der Theorie) in Form eines farblosen Feststoffs erhalten. 1 H-NMR (400 MHz, d6-DMSO) δ ppm 8.06 (d, 1H), 7.73 (br. s, 1H, NH), 7.68 (m, 2H), 7.41-7.36 (m, 2H), 7.30 (d, 1H), 7.16-7.12 (m, 2H), 6.92-6.69 (m, 1H), 4.41-4.36 (m, 1H), 4.18-4.14 (m, 1H), 3.70-3.66 (dd, 1H), 3.00-2.94 (dd, 1H), 2.43-2.38 (dd, 1H), 2.14 (s, 3H). I.5-4: 1-(2,5-Dichlorphenyl)-3-[1-(2-fluorphenyl)-5-oxopyrrolidin-3 -yl]thioharnstoff. Itaconsäure (100 mmol, 1 Äquiv.) und 2-Fluoranilin (100 mmol, 1 Äquiv.) wurden zusammen in einen ausgeheizten Rundkolben gegeben und 16 h lang bei bei einer Temperatur von 150 °C gerührt. Nach dem Abkühlen auf Raumtemperatur wurde das Reaktionsgemisch unter vermindertem Druck eingeengt Durch Umkristallisieren aus Essigester wurde 1-(2-Fluorphenyl)-5-oxopyrrolidin-3-carbonsäure in Form eines farblosen Feststoffs erhalten und ohne weitere Reinigung im nächsten Reaktionsschritt eingesetzt. 1-(2-Fluorphenyl)-5-oxopyrrolidin-3-carbonsäure (48.8 mmol, 1 Äquiv.) wurde in tert. Butanol (100 mL) gelöst und mit Diphenylphosphorylazid (58.8 mmol, 1.2 Äquiv.) und Triethylamin (146.4 mmol, 3.0 Äquiv.) versetzt. Das resultierende Reaktionsgemisch wurde 2 h lang bei 80 °C gerührt, nach dem Abkühlen auf Raumtemperatur unter vermindertem Druck eingeengt und das erhaltene Rohprodukt ohne weitere Reinigung in einem Gemisch aus Salzsäure und Essigester (100 mL) aufgenommen und 16 h lang bei Raumtemperatur gerührt. Der ausgefallene Feststoff wurde abfiltriert und getrocknet. Auf diese Weise konnte 4-Amino-1-(2-fluorphenyl)pyrrolidin-2-on in Form eines farblosen Feststoffs erhalten werden.4-Amino-1-(2-fluorphenyl)pyrrolidin-2-on (150 mg, 0.65 mmol) wurde in einem ausgeheizten Rundkolben in abs. Dichlormethan (5 mL) gelöst und mit Triethylamin (0.23 mL, 1.63 mmol) versetzt. Nach 10 Minuten Rühren bei Raumtemperatur erfolgte die Zugabe von 2,5-Dichlorphenylisothiocyanat (146 mg, 0.72 mmol). Das resultierende Reaktionsgemisch wurde 2 h bei Raumtemperatur gerührt, mit Wasser und Dichlormethan versetzt und gründlich extrahiert. Die vereinigten organischen Phasen würden über Magnesiumsulfat getrocknet, abfiltriert und unter vermindertem Druck eingeeingt. Durch säulenchromatographische Reinigung (Gradient Essigester/Heptan) des erhaltenen Rohproduktes wurde 1-(2,5-Dichlorphenyl)-3-[1-(2-fluorphenyl)-5-oxopyrrolidin-3 -yl]thioharnstoff (176 mg, 68% der Theorie) in Form eines farblosen Feststoffs erhalten. 1 H-NMR (400 MHz, CDCl 3 ) δ ppm 7.86 (br. d, 1H, NH), 7.75 (br. s, 1H, NH), 7.45-7.30 (m, 3H), 7.28-7.08 (m, 4H), 5.16-5.11 (m, 1H), 4.23-4.19 (m, 1H), 3.97-3.93 (dd, 1H), 3.11-3.04 (dd, 1H), 2.53-2.48 (dd, 1H). I.5-10: 1-(5-Chlor-2-methylphenyl)-3-[1-(2-fluorphenyl)-5-oxopyrroli din-3-yl]thioharnstoff. 4-Amino-1-(2-fluorphenyl)pyrrolidin-2-on (150 mg, 0.65 mmol) wurde in einem ausgeheizten Rundkolben in abs. Dichlormethan (5 mL) gelöst und mit Triethylamin (0.23 mL, 1.63 mmol) versetzt. Nach 10 Minuten Rühren bei Raumtemperatur erfolgte die Zugabe von 2-Methyl-5- Chlorphenylisothiocyanat (132 mg, 0.72 mmol). Das resultierende Reaktionsgemisch wurde 2 h bei Raumtemperatur gerührt, mit Wasser und Dichlormethan versetzt und gründlich extrahiert. Die vereinigten organischen Phasen würden über Magnesiumsulfat getrocknet, abfiltriert und unter vermindertem Druck eingeeingt. Durch säulenchromatographische Reinigung (Gradient Essigester/Heptan) des erhaltenen Rohproduktes wurde 1-(5-Chlor-2-methylphenyl)-3-[1-(2- fluorphenyl)-5-oxopyrrolidin-3-yl]thioharnstoff (206 mg, 84% der Theorie) in Form eines farblosen Feststoffs erhalten. 1 H-NMR (400 MHz, CDCl3) δ ppm 7.52 (br. s, 1H, NH), 7.35-7.22 (m, 4H), 7.18- 7.10 (m, 3H), 6.01 (br. d, 1H, NH), 5.21-5.17 (m, 1H), 4.23-4.18 (m, 1H), 3.84-3.80 (dd, 1H), 3.05-2.99 (dd, 1H), 2.45-2.40 (dd, 1H), 2.24 (s, 3H). I.5-21: 1-(5-Chlor-2-methylphenyl)-3-[1-cyclopropyl-5-oxopyrrolidin- 3-yl]thioharnstoff. 4-Amino-1-cyclopropylpyrrolidin-2-on (150 mg, 0.85 mmol) wurde in einem ausgeheizten Rundkolben in abs. Dichlormethan (5 mL) gelöst und mit Triethylamin (0.30 mL, 2.12 mmol) versetzt. Nach 10 Minuten Rühren bei Raumtemperatur erfolgte die Zugabe von 2-Methyl-5-Chlorphenylisothiocyanat (172 mg, 0.93 mmol). Das resultierende Reaktionsgemisch wurde 2 h bei Raumtemperatur gerührt, mit Wasser und Dichlormethan versetzt und gründlich extrahiert. Die vereinigten organischen Phasen würden über Magnesiumsulfat getrocknet, abfiltriert und unter vermindertem Druck eingeeingt. Durch säulenchromatographische Reinigung (Gradient Essigester/Heptan) des erhaltenen Rohproduktes wurde 1-(5-Chlor-2-methylphenyl)-3-[1-cyclopropyl-5-oxopyrrolidin- 3-yl]thioharnstoff (213 mg, 77% der Theorie) in Form eines farblosen Feststoffs erhalten. 1 H-NMR (400 MHz, d 6 -DMSO) δ ppm 9.07 (br. s, 1H, NH), 8.18-8.10 (br. s, 1H, NH), 7.41 (m, 1H), 7.26 (m, 1H), 7.19 (m, 1H), 4.80-4.72 (m, 1H), 3.63- 3.59 (dd, 1H), 3.16-3.12 (dd, 1H), 2.64-2.60 (m, 1H), 2.32 (m, 1H), 2.28-2.24 (dd, 1H), 2.14 (s, 3H), 0.67- 0.60 (m, 4H). I.5-34: 2-(5-Chlor-2-methylphenyl)-N-[1-(chinolin-8-yl)-5-oxopyrroli din-3-yl]thioharnstoff. 4-Amino-1-(chinolin-8-yl)pyrrolidin-2-on Hydrochloridsalz (150 mg, 0.57 mmol) wurde in einem ausgeheizten Rundkolben in abs. Dichlormethan (5 mL) gelöst und mit Triethylamin (0.19 mL, 1.42 mmol) versetzt. Nach 10 Minuten Rühren bei Raumtemperatur erfolgte die Zugabe von 5-Chlor-2- methylphenylisothiocyanat (115 mg, 0.63 mmol). Das resultierende Reaktionsgemisch wurde 2 h bei Raumtemperatur gerührt, mit Wasser und Dichlormethan versetzt und gründlich extrahiert. Die vereinigten organischen Phasen würden über Magnesiumsulfat getrocknet, abfiltriert und unter vermindertem Druck eingeeingt. Durch säulenchromatographische Reinigung (Gradient Essigester/Heptan) des erhaltenen Rohproduktes wurde 2-(5-Chlor-2-methylphenyl)-N-[1-(chinolin-8- yl)-5-oxopyrrolidin-3-yl]thioharnstoff (100 mg, 43% der Theorie) in Form eines farblosen Feststoffs erhalten. 1 H-NMR (400 MHz, d6-DMSO) δ ppm 9.24 (m, 1H), 8.87 (m, 1H), 8.46 (dd, 1H), 8.42-8.33 (br. s, 1H, NH), 7.99 (m, 1H), 7.74 (d, 1H), 7.68-7.64 (dd, 1H), 7.61 (dd, 1H), 7.51 (m, 1H), 7.44 (m, 1H), 7.27 (m, 1H), 7.21 (m, 1H), 5.14-5.08 (m, 1H), 4.37-4.33 (dd, 1H), 3.97-3.94 (dd, 1H), 3.02-2.96 (dd, 1H), 2.68-2.59 (dd, 1H), 2.18 (s, 3H). In Analogie zu den oben angeführten und an entsprechender Stelle rezitierten Herstellungsbeispielen und unter Berücksichtigung der allgemeinen Angaben zur Herstellung von Pyrrolidinonen der allgemeinen Formel (I) erhält man die nachfolgend genannten Verbindungen, Tabelle I.1: Bevorzugt für die Verwendung von Verbindungen der Formel (I.1) sind die Verbindungen I.1-1 bis I.1-605, worin R 1 , R 4 , R 13 und X die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle I.1 haben und R 3 , R 5 , R 6 , R 7 und R 14 Wasserstoff sind und worin X für eine Gruppierung O-R 36 oder N(R 15 )R 35 steht. Die Stereochemie am Kohlenstoff C-2 wird mit „RAC“ für ein Gemisch beider Stereokonfigurationen am Kohlenstoff C-2, „Ent-1“ und „Ent-2“ für jeweils ein Enantiomer (oder Diastereomer bei mehreren Stereozentren im Molekül) mit einer definierten Stereokonfiguration am Kohlenstoff C-2 angegeben. Tabelle I.1

Tabelle I.2: Bevorzugt für die Verwendung von Verbindungen der Formel (I.2) sind die Verbindungen I.2-1 bis I.2-182, worin R 1 , R 3 , R 4 , R 5 , R 20 , R 21 und R 37 die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle I.2 haben und R 2 , R 6 und R 22 Wasserstoff sind. Die mit einem Stern (*) gekennzeichneten Bindungen der gemeinsam von R3 und R5 gebildeten Gruppen geben die Bindungen zum Pyrrolidinonring an. Bei den mit zwei Sternen (**) gekennzeichneten Gruppierungen bilden R 21 und R 37 gemeinsam mit dem Kohlenstoffatom, an das sie gebunden sind, ein Ringsystem, das gegebenenfalls auch bicyclisch sein kann. Das so unter Einbeziehung des Kohlenstoffatoms gebildete Ringsystem wird dann entsprechend in einer gemeinsamen Spalte für R 21 und R 37 angegeben. Tabelle I.2

Tabelle I.3: Bevorzugt für die Verwendung von Verbindungen der Formel (I.3) sind die Verbindungen I.3-1 bis I.3-37, worin R 1 , R 3 , R 5 , R 10 und R 37 die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle I.3 haben und R 2 , R 4 , R 6 , R 11 und R 12 Wasserstoff sind. Tabelle I.3

Tabelle I.4: Bevorzugt für die Verwendung von Verbindungen der Formel (I.4) sind die Verbindungen I.4-1 bis I.4-141, worin R 1 , R 3 , R 5 und R 37 die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle I.4 haben und R 2 , R 4 , R 6 , R 8 und R 9 Wasserstoff sind. Tabelle I.4

Tabelle I.5: Bevorzugt für die Verwendung von Verbindungen der Formel (I.5) sind die Verbindungen I.5-1 bis I.5-34, worin R 1 , R 3 , R 5 und R 37 die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle I.5 haben und R 2 , R 4 und R 6 Wasserstoff sind. , Tabelle I.5 4

Spektroskopische Daten ausgewählter Tabellenbeispiele: Die nachfolgend aufgeführten spektroskopischen Daten ausgewählter Tabellenbeispiele wurden entweder über klassische NMR-Interpretation und/oder über 1 H-NMR-Peak-Listenverfahren ausgewertet. a) Klassische Interpretation: Beispiel Nr. I.4-3: 1 H-NMR (400 MHz, d6-DMSO) δ ppm 8.17 (d, 1H), 8.09 (br. s, 1H, NH), 7.64 (d, 1H), 7.58 (d, 1H), 7.46-7.34 (m, 4H), 7.26 (m, 1H), 6.98 (m, 1H), 4.49-4.44 (m, 1H), 4.05-4.00 (m, 1H), 3.59-3.53 (dd, 1H), 2.94-2.87 (dd, 1H), 2.37-2.31 (dd, 1H). Beispiel Nr. I.4-4: 1 H-NMR (400 MHz, d6-DMSO) δ ppm 8.50 (br. s, 1H, NH), 7.55 (d, 2H), 7.43 (d, 2H), 7.28 (d, 2H), 7.19 (d, 2H), 6.81 (br. d, 1H, NH), 4.42-4.36 (m, 1H), 4.14-4.08 (m, 1H), 3.69-3.63 (dd, 1H), 2.94-2.87 (dd, 1H), 2.47-2.40 (dd, 1H), 2.28 (s, 3H). Beispiel Nr. I.4-15: 1 H-NMR (400 MHz, d 6 -DMSO) δ ppm 8.81 (s, 1H), 8.42 (br. m, 1H, NH), 7.95 (m, 1H), 7.57 (d, 2H), 7.39 (d, 1H), 7.00 (br. d, 1H, NH), 6.96 (d, 2H), 4.42-4.38 (m, 1H), 4.14-4.08 (m, 1H), 3.75 (s, 3H), 3.67-3.63 (dd, 1H), 2.93-2.86 (dd, 1H), 2.47-2.41 (dd, 1H). Beispiel Nr. I.4-16: 1 H-NMR (400 MHz, d 6 -DMSO) δ ppm 8.89 (s, 1H), 8.42 (br. m, 1H, NH), 7.96 (m, 1H), 7.58 (m, 1H), 7.46-7.39 (m, 4H), 7.00 (br. d, 1H, NH), 4.51-4.45 (m, 1H), 4.02-3.97 (m, 1H), 3.59-3.54 (dd, 1H), 2.89- 2.81 (dd, 1H), 2.46-2.39 (dd, 1H). Beispiel Nr. I.4-17: 1 H-NMR (400 MHz, d6-DMSO) δ ppm 8.62 (br. s, 1H, NH), 7.89 (s, 1H), 7.54 (d, 1H), 7.45-7.35 (m, 3H), 7.29 (d, 2H), 6.80 (br. d, 1H, NH), 4.51-4.45 (m, 1H), 4.02-3.97 (m, 1H), 3.59-3.54 (dd, 1H), 2.85- 2.81 (dd, 1H), 2.44-2.37 (dd, 1H). Beispiel Nr. I.4-18: 1 H-NMR (400 MHz, d6-DMSO) δ ppm 8.69 (br. s, 1H, NH), 7.59 (d, 1H), 7.49-7.34 (m, 5H), 7.28 (d, 2H), 7.22 (d, 1H), 6.82 (br. d, 1H, NH), 4.43-4.38 (m, 1H), 4.18-4.14 (m, 1H), 3.72-3.68 (dd, 1H), 2.96- 2.91 (dd, 1H), 2.46 (dd, 1H). Beispiel Nr. I.4-19: 1 H-NMR (400 MHz, d6-DMSO) δ ppm 8.18 (m, 1H), 8.00 (br. s, 1H, NH), 7.91 (s, 1H), 7.65 (d, 1H), 7.57 (d, 1H), 7.48-7.39 (m, 2H), 7.30-7.22 (m, 2H), 6.99-6.96 (m, 1H), 4.43-4.38 (m, 1H), 4.19-4.14 (m, 1H), 3.73-3.69 (dd, 1H), 3.03-2.96 (dd, 1H), 2.46-2.40 (dd, 1H). Beispiel Nr. I.4-20: 1 H-NMR (400 MHz, d6-DMSO) δ ppm 8.18 (d, 1H), 8.00 (br. s, 1H, NH), 7.72 (d, 2H), 7.67 (d, 1H), 7.48-7.42 (m, 3H), 7.22 (m, 1H), 6.99-6.96 (m, 1H), 4.43-4.37 (m, 1H), 4.18-4.13 (m, 1H), 3.70-3.66 (dd, 1H), 3.03-2.95 (dd, 1H), 2.47-2.39 (dd, 1H). Beispiel Nr. I.4-27: 1 H-NMR (400 MHz, d 6 -DMSO) δ ppm 9.26 (br. s, 1H, NH), 8.92 (br. m, 1H), 7.73 (d, 2H), 7.57 (m, 1H), 7.46 (d, 2H), 7.12 (d, 1H), 6.81 (d, 1H), 4.51-4.41 (m, 1H), 4.19-4.14 (m, 1H), 3.75-3.70 (dd, 1H), 3.02-2.94 (dd, 1H), 2.47 (m, 1H), 2.33 (s, 3H). Beispiel Nr. I.4-31: 1 H-NMR (400 MHz, d 6 -DMSO) δ ppm 8.82 (s, 1H), 8.42 (d, 1H), 7.95-7.91 (m, 1H), 7.71 (d, 2H), 7.45 (d, 2H), 7.38 (d, 1H), 7.03 (m, 1H), 4.45-4.38 (m, 1H), 4.16-4.11 (m, 1H), 3.71-3.66 (dd, 1H), 2.97-2.90 (dd, 1H), 2.49-2.45 (dd, 1H). Beispiel Nr. I.4-32: 1 H-NMR (400 MHz, d 6 -DMSO) δ ppm 8.89 (s, 1H), 8.43 (d, 1H), 7.97-7.93 (m, 1H), 7.59 (d, 1H), 7.46- 7.38 (m, 4H), 7.01 (m, 1H), 4.52-4.45 (m, 1H), 4.02-3.97 (m, 1H), 3.59-3.54 (dd, 1H), 2.89-2.82 (dd, 1H), 2.45-2.38 (dd, 1H). Beispiel Nr. I.4-34: 1 H-NMR (400 MHz, d6-DMSO) δ ppm 9.26 (s, 1H), 8.93 (br. m, 1H), 7.68-7.65 (m, 2H), 7.58 (m, 1H), 7.40-7.34 (m, 2H), 7.17-7.10 (m, 2H), 6.80 (d, 1H), 4.52-4.45 (m, 1H), 4.21-4.16 (m, 1H), 3.76-3.72 (dd, 1H), 3.01-2.94 (dd, 1H), 2.49-2.43 (m, 1H), 2.32 (s, 3H). Beispiel Nr. I.4-37: 1 H-NMR (400 MHz, d6-DMSO) δ ppm 9.35 (s, 1H), 8.84 (br. m, 1H), 7.63-7.59 (m, 1H), 7.50 (d, 2H), 7.20-7.13 (m, 3H), 6.84 (d, 1H), 4.48-4.43 (m, 1H), 4.18-4.13 (m, 1H), 3.72-3.68 (dd, 1H), 2.98-2.92 (dd, 1H), 2.49-2.43 (m, 1H), 2.35 (s, 3H), 2.28 (s, 3H). Beispiel Nr. I.4-38: 1 H-NMR (400 MHz, d6-DMSO) δ ppm 8.59 (br. s, 1H, NH), 7.55 (d, 2H), 7.42 (d, 2H), 7.29 (d, 2H), 6.96 (d, 2H), 6.81 (br. d, 1H, NH), 4.40-4.37 (m, 1H), 4.14-4.08 (m, 1H), 3.75 (s, 3H), 3.65-3.61 (dd, 1H), 2.92-2.85 (dd, 1H), 2.45-2.39 (dd, 1H). Beispiel Nr. I.4-41: 1 H-NMR (400 MHz, d6-DMSO) δ ppm 8.18 (d, 1H), 8.00 (br. s, 1H, NH), 7.64 (d, 1H), 7.58 (d, 2H), 7.42 (d, 1H), 7.25 (m, 1H), 6.99-6.90 (m, 3H), 4.40-4.37 (m, 1H), 4.17-4.11 (m, 1H), 3.75 (s, 3H), 3.65- 3.61 (dd, 1H), 2.97-2.90 (dd, 1H), 2.39-2.34 (dd, 1H). b) 1 H-NMR-Peak-Listenverfahren: Zu jedem Signalpeak wird beim 1 H-NMR-Peak-Listenverfahren erst der δ-Wert in ppm und dann die Signalintensität in runden Klammern aufgeführt. Die δ-Wert – Signalintensitäts- Zahlenpaare von verschiedenen Signalpeaks werden durch Semikolons voneinander getrennt aufgelistet. Die Peakliste eines Beispieles hat daher die Form: δ1 (Intensität1 ) ; δ2 (Intensität2);……..; δi (Intensitäti ) ;……; δn (Intensitätn) Die Intensität scharfer Signale korreliert mit der Höhe der Signale in einem gedruckten Beispiel eines NMR-Spektrums in cm und zeigt die wirklichen Verhältnisse der Signalintensitäten. Bei breiten Signalen können mehrere Peaks oder die Mitte des Signals und ihre relative Intensität im Vergleich zum intensivsten Signal im Spektrum gezeigt werden. Zur Kalibrierung der chemischen Verschiebung von 1 H- NMR-Spektren benutzen wir Tetramethylsilan und/oder die chemische Verschiebung des Lösungsmittels, besondern im Falle von Spektren, die in DMSO gemessen werden. Daher kann in NMR-Peaklisten der Tetramethylsilan-Peak vorkommen, muss es aber nicht. Die Listen der 1 H-NMR-Peaks sind ähnlich den klassischen 1H-NMR-Ausdrucken und enthalten somit gewöhnlich alle Peaks, die bei einer klassischen NMR-Interpretation aufgeführt werden. Darüber hinaus können sie wie klassische 1H-NMR-Ausdrucke Lösungsmittelsignale, Signale von Stereoisomeren der Zielverbindungen, die ebenfalls Gegenstand der Erfindung sind, und/oder Peaks von Verunreinigungen zeigen. Bei der Angabe von Verbindungssignalen im Delta-Bereich von Lösungsmitteln und/oder Wasser sind in unseren Listen von 1H-NMR-Peaks die gewöhnlichen Lösungsmittelpeaks, zum Beispiel Peaks von DMSO in DMSO-D 6 und der Peak von Wasser, gezeigt, die gewöhnlich im Durchschnitt eine hohe Intensität aufweisen. Die Peaks von Stereoisomeren der Targetverbindungen und/oder Peaks von Verunreinigungen haben gewöhnlich im Durchschnitt eine geringere Intensität als die Peaks der Zielverbindungen (zum Beispiel mit einer Reinheit von >90%). Solche Stereoisomere und/oder Verunreinigungen können typisch für das jeweilige Herstellungsverfahren sein. Ihre Peaks können somit dabei helfen, die Reproduktion unseres Herstellungsverfahrens anhand von “Nebenprodukt-Fingerabdrücken” zu erkennen. Einem Experten, der die Peaks der Zielverbindungen mit bekannten Verfahren (MestreC, ACD- Simulation, aber auch mit empirisch ausgewerteten Erwartungswerten) berechnet, kann je nach Bedarf die Peaks der Zielverbindungen isolieren, wobei gegebenenfalls zusätzliche Intensitätsfilter eingesetzt werden. Diese Isolierung wäre ähnlich dem betreffenden Peak-Picking bei der klassischen 1H-NMR- Interpretation. Weitere Details zu 1 H-NMR-Peaklisten können der Research Disclosure Database Number 564025 entnommen werden. I.1-001: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.5273 (2.0); 7.5223 (2.0); 7.5084 (3.3); 7.5029 (3.8); 7.4915 (2.3); 7.4850 (2.1); 7.2549 (0.9); 7.2500 (1.3); 7.2354 (3.2); 7.2306 (2.6); 7.2210 (4.2); 7.2169 (11.7); 7.1976 (6.6); 7.1784 (1.9); 4.7268 (3.0); 4.6869 (3.5); 4.2494 (3.9); 4.2092 (3.3); 3.7943 (0.8); 3.7839 (1.2); 3.7730 (1.8); 3.7635 (2.0); 3.7532 (1.8); 3.7426 (1.4); 3.7323 (0.5); 3.3770 (8.7); 3.1663 (3.3); 2.7741 (0.6); 2.7116 (3.2); 2.7014 (3.2); 2.6717 (4.3); 2.6615 (4.0); 2.5239 (2.2); 2.5192 (3.2); 2.5105 (50.3); 2.5059 (111.3); 2.5013 (155.7); 2.4967 (108.8); 2.4921 (48.1); 2.4468 (1.3); 2.4301 (1.1); 2.4057 (6.4); 2.3889 (2.1); 2.3835 (5.6); 2.3658 (4.0); 2.3517 (0.7); 2.3437 (3.4); 2.3328 (0.7); 2.3280 (1.0); 2.3234 (0.7); 2.2930 (1.5); 2.2801 (1.6); 2.2685 (2.8); 2.2557 (2.7); 2.2269 (3.6); 2.2171 (2.2); 2.2045 (1.4); 2.1993 (1.2); 2.1869 (1.8); 2.1803 (0.9); 2.1746 (0.7); 2.1677 (1.2); 2.1620 (1.0); 2.1432 (0.6); 1.7575 (1.7); 1.7466 (1.7); 1.7357 (1.9); 1.7284 (1.0); 1.7228 (1.0); 1.7180 (1.1); 1.7039 (1.1); 1.6914 (0.8); 1.6346 (0.6); 1.6181 (0.8); 1.6008 (0.6); 1.4445 (0.9); 1.4247 (1.2); 1.4052 (1.2); 1.3877 (0.7); 0.8894 (16.0); 0.8729 (15.3); -0.0002 (15.0). I.1-002: 1 H-NMR (400.1 MHz, d6-DMSO): δ= 12.5234 (0.5); 12.4463 (0.6); 12.4011 (0.6); 12.3590 (0.6); 12.3360 (0.6); 12.3258 (0.6); 12.2780 (0.7); 12.1966 (0.5); 12.1506 (0.6); 12.1440 (0.7); 12.0718 (0.6); 11.9413 (0.6); 7.8181 (1.0); 7.3820 (2.6); 7.3781 (2.8); 7.3614 (5.7); 7.3576 (6.4); 7.3516 (3.8); 7.3354 (6.3); 7.3318 (5.8); 7.3157 (3.7); 7.3111 (3.4); 7.2096 (2.9); 7.2057 (3.4); 7.1967 (3.7); 7.1897 (6.5); 7.1858 (6.7); 7.1770 (6.4); 7.1734 (7.0); 7.1693 (4.9); 7.1654 (4.3); 7.1564 (3.9); 7.1531 (4.1); 7.1289 (0.6); 7.0951 (6.4); 7.0791 (8.9); 7.0600 (4.8); 7.0447 (0.9); 4.7423 (9.6); 4.7028 (11.4); 4.6780 (0.5); 4.2544 (12.5); 4.2148 (10.8); 3.8881 (0.5); 3.7898 (2.2); 3.7796 (4.0); 3.7687 (5.6); 3.7581 (6.4); 3.7484 (5.9); 3.7379 (4.7); 3.7278 (2.4); 3.6940 (0.7); 3.6517 (0.6); 3.6114 (0.7); 3.5977 (3.7); 3.5672 (0.9); 3.5600 (1.0); 3.5540 (1.1); 3.5249 (1.3); 3.5026 (1.4); 3.3613 (79.3); 3.1682 (10.0); 3.1265 (0.8); 3.1082 (0.8); 3.0944 (0.8); 3.0342 (0.6); 2.9971 (0.6); 2.7039 (9.7); 2.6935 (9.8); 2.6743 (4.0); 2.6698 (5.5); 2.6642 (14.6); 2.6538 (12.4); 2.5566 (2.4); 2.5520 (2.6); 2.5472 (1.4); 2.5398 (2.5); 2.5232 (7.9); 2.5185 (11.8); 2.5099 (249.1); 2.5053 (560.3); 2.5007 (795.0); 2.4961 (586.7); 2.4916 (296.0); 2.4499 (7.0); 2.4287 (5.2); 2.4192 (4.3); 2.4042 (10.1); 2.4007 (16.0); 2.3876 (7.2); 2.3788 (15.7); 2.3724 (4.6); 2.3609 (12.0); 2.3520 (2.9); 2.3388 (11.3); 2.3323 (4.7); 2.3274 (5.6); 2.3232 (4.1); 2.3185 (2.5); 2.2891 (5.3); 2.2761 (5.7); 2.2646 (8.5); 2.2516 (9.1); 2.2366 (1.7); 2.2205 (8.2); 2.2116 (6.6); 2.2067 (5.9); 2.1966 (5.3); 2.1914 (4.4); 2.1859 (3.1); 2.1791 (6.2); 2.1721 (3.4); 2.1663 (2.6); 2.1594 (4.1); 2.1537 (3.7); 2.1346 (2.1); 2.0720 (4.0); 1.8683 (0.7); 1.7841 (1.0); 1.7612 (2.6); 1.7562 (5.6); 1.7451 (5.6); 1.7328 (6.1); 1.7268 (3.6); 1.7212 (3.5); 1.7149 (4.2); 1.7023 (3.7); 1.6901 (2.5); 1.2552 (0.6); 0.9771 (0.6); 0.0082 (3.3) I.1-003: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 12.3726 (10.8); 7.3860 (2.9); 7.3820 (3.1); 7.3656 (6.0); 7.3615 (6.6); 7.3554 (3.4); 7.3458 (4.3); 7.3395 (6.5); 7.3354 (5.7); 7.3193 (3.6); 7.3153 (3.4); 7.2112 (4.0); 7.2073 (4.3); 7.1985 (4.1); 7.1946 (4.9); 7.1913 (7.5); 7.1875 (8.0); 7.1785 (7.3); 7.1750 (8.2); 7.1710 (5.1); 7.1670 (5.0); 7.1582 (4.3); 7.1545 (4.7); 7.0958 (7.8); 7.0799 (10.5); 7.0765 (9.7); 7.0604 (5.4); 4.7435 (12.3); 4.7039 (14.3); 4.2546 (16.0); 4.2150 (13.8); 3.7886 (2.6); 3.7781 (4.9); 3.7672 (6.9); 3.7572 (7.4); 3.7472 (6.8); 3.7367 (5.4); 3.7261 (2.2); 3.3520 (1.4); 3.3265 (262.8); 3.2764 (1.3); 2.7083 (13.1); 2.6981 (13.3); 2.6756 (1.7); 2.6684 (17.1); 2.6582 (16.1); 2.5414 (0.6); 2.5246 (2.6); 2.5199 (4.1); 2.5112 (54.6); 2.5066 (116.9); 2.5020 (160.6); 2.4974 (109.1); 2.4928 (47.5); 2.4478 (3.6); 2.4304 (4.2); 2.4210 (2.6); 2.4064 (10.6); 2.4021 (19.0); 2.3892 (7.7); 2.3801 (19.3); 2.3723 (3.8); 2.3622 (14.6); 2.3508 (1.9); 2.3402 (14.1); 2.3289 (1.6); 2.3242 (1.1); 2.3197 (0.6); 2.2899 (6.2); 2.2770 (6.9); 2.2655 (11.3); 2.2526 (11.0); 2.2374 (1.1); 2.2241 (9.0); 2.2209 (9.6); 2.2188 (9.2); 2.2129 (6.6); 2.2103 (6.2); 2.2069 (6.6); 2.1965 (5.9); 2.1909 (4.6); 2.1858 (2.6); 2.1787 (7.2); 2.1721 (3.7); 2.1665 (2.6); 2.1594 (4.7); 2.1533 (4.2); 2.1350 (2.4); 2.0748 (0.8); 1.7822 (1.1); 1.7601 (3.1); 1.7543 (7.0); 1.7431 (7.2); 1.7355 (4.6); 1.7301 (7.2); 1.7250 (4.2); 1.7194 (4.0); 1.7136 (5.0); 1.7005 (4.4); 1.6878 (2.9); 0.0080 (1.6); 0.0063 (0.5); 0.0055 (0.6); 0.0047 (0.7); 0.0039 (0.8); 0.0022 (2.2); -0.0002 (53.4); -0.0051 (1.0); -0.0059 (0.7); -0.0068 (0.6); -0.0085 (1.6) I.1-004: 1 H-NMR (400.1 MHz, d6-DMSO): δ= 11.1978 (0.8); 7.3828 (0.5); 7.3780 (0.4); 7.3621 (1.2); 7.3577 (1.1); 7.3414 (1.2); 7.3370 (1.3); 7.3163 (0.7); 7.2178 (0.3); 7.2142 (0.4); 7.2056 (0.7); 7.1942 (1.1); 7.1858 (1.4); 7.1774 (1.2); 7.1738 (1.3); 7.1653 (0.9); 7.1532 (0.6); 7.0797 (1.4); 7.0636 (0.7); 4.7699 (1.0); 4.7432 (1.3); 4.7300 (1.2); 4.7031 (1.4); 4.3015 (1.2); 4.2554 (1.8); 4.2153 (1.4); 3.9266 (0.4); 3.9162 (0.5); 3.9053 (0.6); 3.8949 (0.6); 3.8846 (0.4); 3.8383 (16.0); 3.7797 (0.5); 3.7701 (0.8); 3.7600 (0.9); 3.7491 (0.8); 3.7392 (0.6); 3.3704 (18.0); 3.1686 (1.1); 2.9541 (0.6); 2.9442 (0.6); 2.9160 (0.8); 2.9060 (0.7); 2.7041 (1.2); 2.6938 (1.2); 2.6747 (0.5); 2.6699 (0.7); 2.6645 (1.8); 2.6540 (1.6); 2.6354 (0.7); 2.6128 (0.7); 2.5970 (0.6); 2.5747 (0.7); 2.5616 (0.6); 2.5576 (0.6); 2.5530 (0.4); 2.5234 (1.0); 2.5185 (1.7); 2.5101 (31.6); 2.5055 (68.7); 2.5009 (96.0); 2.4964 (70.2); 2.4919 (35.2); 2.4548 (1.0); 2.4497 (1.2); 2.4457 (1.3); 2.4315 (1.2); 2.4141 (1.1); 2.4060 (1.6); 2.4012 (2.0); 2.3887 (1.1); 2.3792 (2.0); 2.3736 (0.7); 2.3611 (1.5); 2.3509 (0.4); 2.3391 (1.4); 2.3328 (1.0); 2.3277 (0.8); 2.3201 (0.7); 2.3085 (0.8); 2.2962 (0.8); 2.2898 (0.8); 2.2765 (0.7); 2.2649 (1.4); 2.2520 (1.3); 2.2481 (1.0); 2.2352 (0.6); 2.2206 (1.3); 2.2119 (1.1); 2.1969 (1.0); 2.1918 (0.9); 2.1788 (0.8); 2.1723 (0.6); 2.1664 (0.4); 2.1604 (0.5); 2.1544 (0.5); 1.8706 (0.4); 1.8587 (0.5); 1.8479 (0.5); 1.8428 (0.5); 1.8363 (0.4); 1.8293 (0.4); 1.8166 (0.3); 1.7621 (0.3); 1.7568 (0.7); 1.7458 (0.7); 1.7329 (0.8); 1.7275 (0.5); 1.7218 (0.4); 1.7157 (0.5); 1.7030 (0.5); 0.0082 (0.5); 0.0000 (17.0) I.1-005: 1 H-NMR (400.1 MHz, d6-DMSO): δ= 8.1838 (0.6); 8.1628 (0.7); 8.1443 (0.5); 8.1236 (0.5); 8.1049 (1.0); 8.0829 (1.1); 7.3769 (0.6); 7.3571 (1.3); 7.3337 (1.3); 7.3113 (0.7); 7.2067 (0.6); 7.1868 (1.4); 7.1742 (1.4); 7.1538 (0.7); 7.0893 (1.0); 7.0733 (1.6); 7.0571 (0.8); 4.7542 (1.4); 4.7372 (0.6); 4.7145 (1.6); 4.6965 (0.8); 4.3978 (1.0); 4.3862 (1.0); 4.3755 (1.0); 4.3640 (1.0); 4.2659 (1.2); 4.2543 (0.9); 4.2457 (0.8); 4.2265 (1.1); 4.2195 (1.0); 4.2050 (1.3); 4.1985 (0.8); 4.1836 (0.6); 4.1675 (0.5); 4.1527 (0.6); 4.1467 (0.5); 4.1318 (0.5); 3.8003 (0.4); 3.7906 (0.7); 3.7806 (1.1); 3.7709 (1.4); 3.7608 (1.2); 3.7502 (0.8); 3.7389 (0.4); 3.3617 (31.2); 3.1683 (2.1); 2.6743 (0.6); 2.6696 (0.8); 2.6650 (0.6); 2.6604 (0.4); 2.6315 (0.4); 2.6210 (0.5); 2.5958 (1.0); 2.5849 (1.4); 2.5742 (0.6); 2.5613 (1.1); 2.5507 (1.4); 2.5399 (1.2); 2.5232 (1.7); 2.5184 (2.7); 2.5098 (44.8); 2.5052 (98.6); 2.5006 (137.4); 2.4960 (99.7); 2.4914 (46.7); 2.4071 (0.5); 2.3998 (1.2); 2.3833 (0.8); 2.3784 (1.3); 2.3657 (2.0); 2.3447 (1.9); 2.3359 (1.4); 2.3322 (1.2); 2.3275 (1.3); 2.3229 (1.5); 2.3150 (1.1); 2.2934 (0.6); 2.2869 (0.5); 2.2786 (1.0); 2.2627 (1.1); 2.2540 (1.1); 2.2509 (1.1); 2.2412 (0.9); 2.2212 (0.5); 2.2096 (0.6); 2.1994 (0.5); 2.1249 (0.4); 2.1047 (0.9); 2.0927 (0.7); 2.0808 (0.9); 2.0723 (1.5); 2.0616 (0.5); 2.0524 (0.8); 2.0491 (0.9); 2.0295 (0.4); 1.8690 (0.6); 1.8571 (0.6); 1.8515 (0.7); 1.8399 (0.6); 1.8335 (0.5); 1.8224 (0.5); 1.8029 (0.6); 1.7945 (0.9); 1.7803 (1.0); 1.7709 (1.1); 1.7607 (1.1); 1.7533 (0.9); 1.7431 (0.8); 1.7294 (0.5); 1.3818 (0.5); 1.3644 (0.4); 1.3582 (0.3); 1.2949 (0.4); 1.2771 (0.6); 1.2600 (0.8); 1.2428 (0.9); 1.2249 (0.7); 1.2073 (0.4); 1.1887 (0.5); 1.1760 (0.5); 1.1694 (0.5); 1.1588 (0.8); 1.1540 (0.6); 1.1408 (0.9); 1.1354 (0.6); 1.1233 (0.7); 1.1066 (0.6); 1.0887 (0.4); 0.8483 (13.7); 0.8336 (16.0); 0.8313 (15.8); 0.8153 (4.9); 0.0082 (0.9) I.1-006: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.3863 (1.5); 7.3823 (1.6); 7.3659 (3.0); 7.3617 (3.4); 7.3556 (1.7); 7.3461 (2.1); 7.3399 (3.3); 7.3357 (2.8); 7.3196 (1.8); 7.3156 (1.7); 7.2075 (1.8); 7.2037 (1.9); 7.1949 (1.9); 7.1911 (2.2); 7.1877 (3.4); 7.1840 (3.6); 7.1750 (3.4); 7.1715 (3.8); 7.1673 (2.3); 7.1635 (2.3); 7.1546 (2.0); 7.1512 (2.2); 7.1089 (3.6); 7.0930 (4.6); 7.0736 (2.3); 4.7514 (5.2); 4.7118 (6.0); 4.2748 (6.7); 4.2351 (5.7); 3.8544 (1.1); 3.8441 (2.1); 3.8339 (3.4); 3.8239 (4.0); 3.8138 (3.4); 3.8037 (2.6); 3.7930 (0.9); 3.4628 (15.4); 3.1689 (0.6); 2.8932 (5.3); 2.8829 (5.5); 2.8533 (7.2); 2.8431 (6.8); 2.6710 (0.5); 2.6664 (0.5); 2.6456 (7.4); 2.6245 (7.2); 2.6058 (5.8); 2.5847 (5.6); 2.5245 (1.2); 2.5197 (1.8); 2.5111 (30.4); 2.5065 (66.8); 2.5019 (93.7); 2.4972 (65.1); 2.4926 (28.7); 2.4590 (1.8); 2.4470 (4.5); 2.4406 (6.1); 2.4313 (9.6); 2.4180 (8.0); 2.4005 (3.4); 2.3949 (2.9); 2.3797 (1.5); 2.3648 (1.0); 2.3287 (0.6); 2.3004 (2.5); 2.2881 (2.8); 2.2758 (5.6); 2.2699 (7.5); 2.2637 (7.0); 2.2547 (10.3); 2.2383 (10.3); 2.2353 (10.2); 2.2289 (3.2); 2.2250 (4.9); 2.2156 (2.7); 2.2096 (2.1); 2.2045 (1.1); 2.1975 (3.3); 2.1912 (1.4); 2.1851 (1.1); 2.1782 (2.0); 2.1725 (1.8); 2.1537 (1.0); 2.0740 (3.4); 1.8160 (0.8); 1.7919 (3.1); 1.7803 (2.4); 1.7703 (2.8); 1.7626 (1.8); 1.7576 (1.8); 1.7535 (1.8); 1.7489 (2.0); 1.7381 (2.0); 1.7263 (1.3); 1.6501 (4.9); 1.5712 (13.8); 1.5641 (16.0); 1.5558 (11.3); -0.0002 (7.0) I.1-009: 1 H-NMR (400.1 MHz, d6-DMSO): δ= 7.3860 (0.3); 7.3818 (0.4); 7.3654 (0.8); 7.3615 (0.8); 7.3556 (0.4); 7.3456 (0.5); 7.3395 (0.8); 7.3356 (0.7); 7.3192 (0.4); 7.3153 (0.4); 7.2123 (0.4); 7.2086 (0.4); 7.1996 (0.5); 7.1957 (0.6); 7.1924 (0.8); 7.1888 (0.9); 7.1796 (0.8); 7.1764 (0.9); 7.1723 (0.6); 7.1684 (0.6); 7.1595 (0.5); 7.1559 (0.5); 7.0953 (0.9); 7.0793 (1.2); 7.0764 (1.1); 7.0600 (0.6); 4.7406 (1.3); 4.7009 (1.6); 4.3621 (2.5); 4.3560 (0.6); 4.3474 (5.0); 4.3389 (0.7); 4.3328 (2.8); 4.2515 (1.7); 4.2119 (1.5); 3.8177 (0.5); 3.8073 (0.8); 3.7971 (0.9); 3.7872 (0.9); 3.7768 (0.6); 3.4789 (2.0); 3.4645 (3.4); 3.4499 (1.9); 3.3678 (10.0); 3.1687 (0.4); 2.9991 (16.0); 2.8276 (1.2); 2.8176 (1.2); 2.7875 (1.6); 2.7774 (1.5); 2.5588 (1.6); 2.5370 (1.6); 2.5186 (1.8); 2.5099 (10.4); 2.5053 (23.0); 2.5007 (32.8); 2.4962 (24.9); 2.4916 (11.6); 2.4522 (0.4); 2.4349 (0.5); 2.4113 (1.0); 2.3936 (0.8); 2.3878 (0.7); 2.3809 (0.3); 2.3722 (0.4); 2.2921 (0.6); 2.2798 (0.6); 2.2677 (1.1); 2.2554 (1.1); 2.2263 (1.8); 2.2161 (1.1); 2.2060 (0.6); 2.2003 (0.5); 2.1878 (0.8); 2.1817 (0.4); 2.1686 (0.5); 2.1629 (0.5); 1.7810 (0.7); 1.7697 (0.6); 1.7594 (0.8); 1.7516 (0.4); 1.7467 (0.4); 1.7421 (0.4); 1.7380 (0.5); 1.7269 (0.5); 0.0000 (9.4) I.1-011: 1 H-NMR (400.1 MHz, d 6 -DMSO): δ= 19.7585 (0.3); 12.9496 (0.4); 12.6612 (0.4); 12.5714 (0.8); 12.5551 (0.6); 12.5285 (0.4); 8.1442 (0.6); 8.1255 (0.6); 8.1082 (0.4); 8.0797 (0.4); 8.0598 (1.4); 8.0365 (1.4); 7.9568 (0.6); 7.4617 (0.3); 7.3773 (0.7); 7.3549 (1.6); 7.3320 (1.6); 7.3094 (0.8); 7.2253 (0.4); 7.1847 (1.5); 7.1715 (1.6); 7.1543 (0.9); 7.0750 (1.9); 4.7539 (0.8); 4.7385 (1.7); 4.7121 (0.7); 4.6979 (1.9); 4.3971 (0.4); 4.3747 (0.4); 4.3452 (1.2); 4.3342 (1.3); 4.3244 (1.2); 4.3128 (1.1); 4.2488 (2.0); 4.2092 (2.0); 4.1683 (0.5); 4.1504 (0.6); 4.1304 (0.4); 4.0761 (0.6); 3.9659 (0.5); 3.9032 (0.3); 3.7811 (1.3); 3.7684 (1.7); 3.6533 (0.3); 3.6104 (0.4); 3.5831 (0.4); 3.5679 (0.5); 3.5390 (0.5); 3.5012 (0.6); 3.4888 (0.7); 3.4613 (0.8); 3.4216 (1.2); 3.3747 (2.8); 3.3178 (191.6); 3.2190 (1.5); 3.1907 (0.9); 3.1759 (2.8); 3.1633 (2.9); 3.1011 (0.3); 3.0923 (0.3); 3.0484 (0.3); 2.9989 (0.4); 2.8911 (4.6); 2.8794 (0.5); 2.8416 (0.4); 2.8290 (0.4); 2.7752 (0.4); 2.7315 (4.7); 2.6721 (3.3); 2.6460 (1.8); 2.6206 (2.3); 2.6130 (2.3); 2.5645 (2.6); 2.5030 (519.5); 2.3986 (2.3); 2.3764 (1.8); 2.3346 (4.2); 2.3020 (1.4); 2.2788 (1.8); 2.2605 (1.4); 2.2543 (1.4); 2.2229 (0.8); 2.1244 (0.5); 2.1025 (0.9); 2.0801 (1.2); 2.0721 (2.0); 2.0494 (1.0); 2.0274 (0.5); 1.8307 (1.2); 1.8156 (1.2); 1.7988 (1.3); 1.7776 (1.1); 1.7098 (0.3); 1.3822 (0.4); 1.3629 (0.4); 1.3493 (0.3); 1.2934 (0.5); 1.2783 (0.8); 1.2600 (0.9); 1.2433 (1.2); 1.2245 (0.8); 1.2092 (0.5); 1.1876 (0.4); 1.1534 (0.8); 1.1343 (1.1); 1.1167 (1.0); 1.0996 (0.8); 1.0820 (0.5); 0.8481 (12.7); 0.8318 (16.0); 0.8156 (4.6); 0.7823 (0.5); 0.1461 (0.5); 0.0081 (4.3); 0.0000 (107.5) I.1-012: 1 H-NMR (400.1 MHz, CDCl3): δ= 7.2629 (13.1); 7.2610 (25.7); 7.1145 (0.4); 7.1026 (0.7); 7.0933 (0.4); 7.0853 (0.7); 7.0780 (0.8); 7.0739 (0.4); 7.0679 (0.4); 7.0594 (2.7); 7.0527 (1.5); 7.0491 (2.4); 7.0407 (0.9); 7.0354 (0.8); 4.8904 (1.0); 4.8871 (1.0); 4.8516 (1.2); 4.8483 (1.1); 4.2618 (1.5); 4.2230 (1.4); 3.9047 (0.5); 3.8944 (0.6); 3.8841 (0.8); 3.8736 (0.7); 3.8632 (0.5); 3.6680 (16.0); 2.7366 (1.0); 2.7264 (1.0); 2.6978 (1.3); 2.6875 (1.2); 2.5364 (0.3); 2.5119 (0.8); 2.4935 (0.7); 2.4877 (0.6); 2.4697 (0.6); 2.4376 (1.8); 2.4238 (0.8); 2.4152 (1.9); 2.3990 (1.8); 2.3765 (1.0); 2.3709 (0.5); 2.3570 (0.5); 2.3170 (0.4); 2.2989 (0.6); 2.2847 (0.4); 2.2793 (0.4); 2.2746 (0.4); 2.2664 (0.6); 2.2602 (0.4); 2.2466 (0.4); 2.2420 (0.4); 1.8760 (0.3); 1.8646 (0.5); 1.8519 (0.6); 1.8432 (0.5); 1.8407 (0.5); 1.8382 (0.4); 1.8320 (0.5); 1.8295 (0.4); 1.8268 (0.4); 1.8194 (0.5); 1.8080 (0.4); 1.5711 (5.5); 0.0019 (4.0) I.1-014: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 12.3682 (1.9); 7.3838 (3.5); 7.3798 (3.8); 7.3634 (7.2); 7.3593 (8.0); 7.3532 (4.1); 7.3437 (5.1); 7.3373 (7.7); 7.3332 (6.6); 7.3173 (4.4); 7.3133 (4.1); 7.2101 (4.5); 7.2062 (4.6); 7.1974 (4.6); 7.1935 (5.5); 7.1902 (8.2); 7.1864 (8.7); 7.1776 (7.9); 7.1739 (9.0); 7.1699 (5.4); 7.1659 (5.4); 7.1572 (4.6); 7.1536 (4.9); 7.0954 (8.4); 7.0793 (11.4); 7.0598 (5.7); 4.7429 (12.5); 4.7028 (14.4); 4.2543 (16.0); 4.2147 (14.0); 3.7888 (2.8); 3.7783 (5.0); 3.7671 (7.2); 3.7574 (7.7); 3.7472 (7.1); 3.7368 (5.5); 3.7262 (2.2); 3.3181 (83.5); 2.7049 (13.3); 2.6947 (13.5); 2.6746 (2.9); 2.6702 (4.7); 2.6651 (18.9); 2.6548 (16.1); 2.5405 (1.3); 2.5238 (9.2); 2.5190 (13.3); 2.5104 (196.8); 2.5058 (432.4); 2.5012 (604.9); 2.4966 (419.9); 2.4920 (185.2); 2.4464 (4.5); 2.4293 (4.4); 2.4193 (2.7); 2.4049 (10.6); 2.3995 (19.2); 2.3879 (7.9); 2.3775 (18.6); 2.3652 (4.6); 2.3597 (14.8); 2.3500 (2.2); 2.3376 (15.2); 2.3280 (3.7); 2.3233 (2.9); 2.2890 (6.6); 2.2760 (7.2); 2.2645 (11.7); 2.2516 (11.2); 2.2231 (9.7); 2.2201 (9.8); 2.2117 (6.8); 2.2061 (6.5); 2.1959 (6.1); 2.1902 (4.8); 2.1780 (7.5); 2.1716 (3.8); 2.1655 (2.7); 2.1587 (5.0); 2.1525 (4.2); 2.1339 (2.4); 2.0734 (1.2); 1.7825 (1.1); 1.7604 (3.2); 1.7549 (7.3); 1.7435 (7.2); 1.7304 (7.2); 1.7256 (4.2); 1.7199 (4.1); 1.7142 (4.8); 1.7011 (4.4); 1.6885 (2.8); 0.1457 (0.9); 0.0080 (9.3); -0.0002 (333.6); -0.0060 (3.4); -0.0085 (9.7); -0.0338 (0.9); -0.1498 (0.9) I.1-015: 1 H-NMR (400.1 MHz, d6-DMSO): δ= 7.3621 (0.5); 7.3583 (0.6); 7.3425 (0.3); 7.3368 (0.6); 7.3325 (0.5); 7.1893 (0.6); 7.1858 (0.6); 7.1765 (0.6); 7.1734 (0.6); 7.1655 (0.4); 7.1532 (0.3); 7.0942 (0.6); 7.0781 (0.8); 7.0590 (0.4); 4.7306 (1.0); 4.6908 (1.1); 4.2636 (1.2); 4.2238 (1.0); 4.1134 (1.6); 4.1039 (1.7); 4.1016 (1.6); 4.0901 (1.9); 3.8187 (0.4); 3.8087 (0.6); 3.7985 (0.7); 3.7884 (0.6); 3.7783 (0.4); 3.5540 (0.3); 3.5057 (2.6); 3.4861 (3.3); 3.4809 (1.6); 3.4743 (2.9); 3.4628 (2.4); 3.2326 (16.0); 2.7929 (0.8); 2.7823 (0.8); 2.7530 (1.1); 2.7425 (1.1); 2.5512 (0.9); 2.5304 (1.2); 2.5235 (0.4); 2.5101 (7.8); 2.5055 (15.5); 2.5010 (21.5); 2.4965 (15.7); 2.4919 (8.0); 2.4384 (0.4); 2.4144 (0.7); 2.3970 (0.6); 2.3908 (0.5); 2.2923 (0.4); 2.2796 (0.4); 2.2678 (0.7); 2.2551 (0.8); 2.2254 (0.9); 2.2155 (0.7); 2.2116 (0.5); 2.2013 (0.4); 2.1957 (0.3); 2.1831 (0.5); 2.1583 (0.3); 1.7654 (0.5); 1.7542 (0.5); 1.7423 (0.6); 1.7247 (0.3); 1.7112 (0.4); 0.0007 (2.6); 0.0000 (2.7) I.1-016: 1 H-NMR (400.1 MHz, d6-DMSO): δ= 8.1813 (0.9); 8.1602 (0.9); 8.1024 (1.2); 8.0802 (1.2); 7.3760 (0.5); 7.3547 (1.2); 7.3328 (1.2); 7.3097 (0.6); 7.2067 (0.6); 7.1869 (1.3); 7.1744 (1.3); 7.1667 (0.8); 7.1541 (0.7); 7.0897 (1.0); 7.0739 (1.6); 7.0585 (0.8); 4.7547 (1.7); 4.7150 (2.0); 4.3988 (1.1); 4.3873 (1.2); 4.3766 (1.1); 4.3651 (1.2); 4.2672 (1.4); 4.2557 (1.1); 4.2276 (1.3); 4.2211 (1.3); 4.2168 (1.1); 4.2064 (1.2); 4.2000 (1.0); 4.1852 (0.9); 3.8011 (0.8); 3.7919 (1.1); 3.7826 (1.5); 3.7725 (1.8); 3.7626 (1.7); 3.7523 (1.4); 3.7412 (1.0); 2.5966 (0.9); 2.5858 (1.4); 2.5752 (0.7); 2.5624 (1.1); 2.5514 (1.9); 2.5408 (1.0); 2.5237 (0.4); 2.5190 (0.6); 2.5103 (12.4); 2.5058 (27.8); 2.5012 (39.6); 2.4966 (28.8); 2.4920 (13.8); 2.4567 (0.3); 2.4078 (0.6); 2.4012 (1.2); 2.3845 (0.9); 2.3799 (1.3); 2.3668 (2.2); 2.3461 (2.2); 2.3374 (1.0); 2.3236 (1.2); 2.3161 (0.8); 2.2785 (0.7); 2.2759 (0.7); 2.2656 (0.8); 2.2631 (0.8); 2.2546 (1.0); 2.2515 (0.9); 2.2415 (1.0); 2.2386 (1.0); 2.2241 (0.5); 2.2213 (0.4); 2.2128 (0.6); 2.2098 (0.5); 2.1999 (0.6); 2.1260 (0.4); 2.1058 (0.8); 2.0942 (0.6); 2.0849 (0.7); 2.0823 (0.7); 2.0745 (1.0); 2.0722 (1.1); 2.0625 (0.4); 2.0538 (0.8); 1.8697 (0.6); 1.8581 (0.6); 1.8523 (0.6); 1.8407 (0.6); 1.8353 (0.4); 1.8232 (0.4); 1.8097 (0.4); 1.8056 (0.5); 1.7966 (0.8); 1.7862 (0.8); 1.7827 (0.9); 1.7729 (1.1); 1.7633 (1.1); 1.7552 (1.0); 1.7517 (0.9); 1.7445 (0.8); 1.7408 (0.8); 1.7295 (0.5); 1.3826 (0.4); 1.3785 (0.4); 1.3672 (0.4); 1.3594 (0.4); 1.3490 (0.3); 1.2969 (0.3); 1.2789 (0.6); 1.2620 (0.7); 1.2446 (0.8); 1.2266 (0.6); 1.2107 (0.4); 1.1928 (0.4); 1.1893 (0.4); 1.1774 (0.4); 1.1705 (0.5); 1.1596 (0.8); 1.1416 (1.0); 1.1238 (0.8); 1.1074 (0.6); 1.0894 (0.4); 0.8493 (11.9); 0.8343 (16.0); 0.8161 (4.9) I.1-017: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 7.3831 (2.0); 7.3792 (2.1); 7.3627 (4.0); 7.3586 (4.4); 7.3526 (2.3); 7.3429 (2.8); 7.3368 (4.3); 7.3325 (3.7); 7.3164 (2.3); 7.3124 (2.1); 7.2081 (2.6); 7.2041 (2.7); 7.1954 (2.6); 7.1914 (3.1); 7.1882 (4.6); 7.1844 (4.9); 7.1755 (4.5); 7.1719 (5.0); 7.1678 (3.0); 7.1638 (2.9); 7.1551 (2.5); 7.1514 (2.9); 7.0874 (4.7); 7.0715 (6.3); 7.0680 (5.7); 7.0520 (3.2); 6.1735 (0.9); 5.0416 (1.8); 5.0346 (3.7); 5.0254 (4.3); 5.0185 (5.9); 5.0117 (3.6); 5.0032 (3.4); 4.7163 (7.1); 4.6765 (8.3); 4.2594 (9.4); 4.2195 (8.0); 3.8187 (1.7); 3.8077 (3.2); 3.7985 (4.4); 3.7878 (6.2); 3.7778 (4.0); 3.7679 (3.4); 3.7570 (1.4); 3.5345 (16.0); 3.1684 (3.0); 2.7094 (7.7); 2.6986 (7.9); 2.6699 (12.2); 2.6591 (10.5); 2.6003 (0.5); 2.5956 (0.5); 2.5612 (0.8); 2.5567 (1.2); 2.5521 (1.3); 2.5474 (0.6); 2.5237 (2.5); 2.5189 (3.8); 2.5103 (67.7); 2.5057 (147.2); 2.5010 (206.5); 2.4964 (148.4); 2.4918 (69.8); 2.4738 (11.6); 2.4544 (6.4); 2.4344 (9.9); 2.4166 (2.2); 2.4078 (1.4); 2.3927 (5.3); 2.3751 (4.3); 2.3691 (3.8); 2.3532 (2.6); 2.3370 (0.6); 2.3325 (1.5); 2.3279 (1.4); 2.3232 (1.0); 2.2980 (3.9); 2.2846 (4.5); 2.2735 (6.8); 2.2602 (6.8); 2.2442 (0.7); 2.2320 (4.4); 2.2239 (6.7); 2.2200 (3.4); 2.2109 (2.9); 2.2080 (3.6); 2.1973 (3.5); 2.1914 (2.7); 2.1866 (1.6); 2.1834 (1.9); 2.1796 (3.9); 2.1728 (2.2); 2.1669 (1.6); 2.1598 (2.7); 2.1533 (2.4); 2.1353 (1.5); 2.0727 (1.1); 1.8271 (0.8); 1.8115 (2.1); 1.8020 (3.0); 1.7880 (5.5); 1.7768 (5.5); 1.7727 (5.8); 1.7651 (5.0); 1.7568 (7.5); 1.7451 (6.3); 1.7380 (3.6); 1.7340 (4.1); 1.7323 (4.1); 1.7287 (3.8); 1.7209 (2.7); 1.7144 (3.9); 1.7025 (2.6); 1.6892 (1.7); 1.6451 (0.6); 1.6320 (1.0); 1.6262 (1.4); 1.6152 (2.6); 1.6037 (4.2); 1.5947 (6.5); 1.5857 (4.9); 1.5832 (4.9); 1.5796 (4.5); 1.5732 (5.5); 1.5667 (4.3); 1.5637 (5.0); 1.5548 (7.4); 1.5442 (12.8); 1.5355 (8.9); 1.5300 (10.2); 1.5219 (9.2); 1.5174 (10.4); 1.5125 (9.2); 1.5072 (7.5); 1.5010 (5.7); 1.4967 (4.2); 1.4877 (2.7); 1.1950 (0.5); 1.1769 (1.1); 1.1586 (0.5); 0.0080 (1.4); -0.0002 (55.1); - 0.0085 (1.7) I.1-020: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 7.3835 (0.9); 7.3794 (0.9); 7.3630 (1.8); 7.3589 (2.0); 7.3529 (1.0); 7.3432 (1.2); 7.3370 (2.0); 7.3328 (1.7); 7.3168 (1.1); 7.3128 (1.0); 7.2114 (1.1); 7.2074 (1.2); 7.1987 (1.1); 7.1948 (1.3); 7.1915 (2.1); 7.1877 (2.2); 7.1788 (2.0); 7.1752 (2.2); 7.1711 (1.4); 7.1672 (1.4); 7.1584 (1.2); 7.1547 (1.3); 7.0971 (2.1); 7.0812 (2.8); 7.0777 (2.6); 7.0617 (1.5); 4.7325 (3.2); 4.6928 (3.8); 4.2733 (4.2); 4.2335 (3.6); 3.8378 (1.0); 3.8304 (15.1); 3.8123 (16.0); 3.7975 (2.0); 3.7873 (1.6); 3.7765 (0.6); 3.3106 (98.6); 3.2828 (0.6); 2.7797 (3.3); 2.7690 (3.3); 2.7400 (4.6); 2.7293 (4.4); 2.6700 (0.6); 2.5511 (0.6); 2.5454 (4.9); 2.5247 (5.3); 2.5189 (2.0); 2.5102 (31.1); 2.5056 (70.4); 2.5010 (92.7); 2.4963 (64.7); 2.4917 (29.4); 2.4852 (4.8); 2.4754 (0.5); 2.4569 (1.3); 2.4391 (0.9); 2.4295 (0.5); 2.4157 (2.4); 2.3983 (1.8); 2.3922 (1.6); 2.3836 (0.7); 2.3765 (0.8); 2.3278 (0.6); 2.2981 (1.7); 2.2853 (1.8); 2.2736 (3.0); 2.2609 (2.9); 2.2316 (3.5); 2.2219 (2.6); 2.2181 (1.9); 2.2084 (1.6); 2.2027 (1.3); 2.1976 (0.6); 2.1908 (1.9); 2.1838 (1.0); 2.1781 (0.7); 2.1712 (1.2); 2.1648 (1.0); 2.1466 (0.6); 2.0725 (0.6); 1.7778 (0.8); 1.7739 (1.9); 1.7628 (1.8); 1.7552 (1.2); 1.7513 (2.0); 1.7446 (1.1); 1.7391 (1.1); 1.7341 (1.2); 1.7314 (1.1); 1.7200 (1.2); 1.7075 (0.8); 1.0693 (0.6); 1.0629 (0.8); 1.0509 (1.6); 1.0494 (1.5); 1.0428 (1.4); 1.0391 (1.1); 1.0310 (3.0); 1.0229 (1.1); 1.0190 (1.5); 1.0126 (1.5); 1.0110 (1.8); 0.9991 (1.0); 0.9927 (0.7); 0.5139 (2.1); 0.5032 (6.3); 0.4987 (7.1); 0.4939 (2.8); 0.4881 (3.0); 0.4828 (7.2); 0.4785 (6.0); 0.4681 (2.6); 0.2467 (2.6); 0.2362 (7.3); 0.2322 (6.8); 0.2244 (6.2); 0.2205 (7.8); 0.2097 (1.8); -0.0002 (9.9) I.1-021: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.3662 (0.7); 7.3621 (0.8); 7.3404 (0.8); 7.3360 (0.7); 7.1942 (0.5); 7.1909 (0.8); 7.1872 (0.8); 7.1782 (0.8); 7.1747 (0.9); 7.1706 (0.5); 7.1667 (0.5); 7.0968 (0.8); 7.0808 (1.1); 7.0775 (1.0); 7.0613 (0.6); 5.9130 (0.5); 5.8992 (1.1); 5.8866 (0.7); 5.8730 (1.3); 5.8700 (0.7); 5.8593 (0.6); 5.8561 (1.4); 5.8434 (0.8); 5.8427 (0.8); 5.8299 (1.4); 5.8162 (0.6); 5.3003 (0.7); 5.2962 (2.1); 5.2921 (2.2); 5.2880 (0.8); 5.2572 (0.6); 5.2531 (1.8); 5.2490 (1.9); 5.2449 (0.7); 5.2206 (0.8); 5.2172 (1.9); 5.2133 (1.8); 5.2099 (0.7); 5.1944 (0.7); 5.1910 (1.7); 5.1871 (1.7); 5.1837 (0.6); 4.7275 (1.2); 4.6877 (1.5); 4.5180 (2.3); 4.5143 (4.0); 4.5107 (2.4); 4.5042 (2.3); 4.5006 (3.9); 4.4969 (2.3); 4.2703 (1.6); 4.2305 (1.4); 3.8294 (0.5); 3.8192 (0.8); 3.8091 (1.0); 3.7991 (0.8); 3.7888 (0.6); 3.4612 (16.0); 2.8291 (1.3); 2.8185 (1.3); 2.7890 (1.7); 2.7784 (1.6); 2.5812 (1.8); 2.5602 (1.8); 2.5411 (1.4); 2.5202 (1.8); 2.5122 (10.8); 2.5077 (23.1); 2.5030 (31.8); 2.4984 (22.5); 2.4939 (10.3); 2.4157 (1.0); 2.3981 (0.8); 2.3922 (0.7); 2.2979 (0.6); 2.2852 (0.7); 2.2734 (1.2); 2.2607 (1.1); 2.2302 (1.1); 2.2277 (1.0); 2.2207 (0.8); 2.2161 (0.7); 2.2060 (0.6); 2.1881 (0.8); 1.7633 (0.7); 1.7522 (0.7); 1.7396 (0.8); -0.0002 (3.0) I.1-022: 1 H-NMR (400.1 MHz, d6-DMSO): δ= 12.4106 (0.4); 12.3700 (0.4); 12.3632 (0.5); 12.3444 (0.5); 12.3338 (0.5); 12.3240 (0.5); 7.3860 (4.9); 7.3663 (13.8); 7.3481 (16.0); 7.3415 (7.3); 7.3370 (13.8); 7.3328 (10.6); 7.3217 (2.6); 7.3166 (5.1); 7.3129 (3.4); 7.2944 (15.5); 7.2037 (10.0); 7.1858 (8.1); 4.6615 (9.8); 4.6225 (11.4); 4.1613 (11.3); 4.1223 (9.8); 3.7632 (1.6); 3.7525 (3.3); 3.7417 (4.7); 3.7323 (4.8); 3.7212 (4.6); 3.7107 (3.7); 3.7001 (1.9); 3.4494 (1.5); 3.1704 (0.4); 2.7033 (7.3); 2.6934 (7.5); 2.6636 (9.3); 2.6536 (8.9); 2.5235 (0.6); 2.5101 (23.3); 2.5056 (51.5); 2.5011 (73.1); 2.4965 (53.5); 2.4920 (26.0); 2.4604 (0.4); 2.4502 (2.4); 2.4416 (0.7); 2.4324 (2.6); 2.4253 (2.6); 2.4084 (5.8); 2.3907 (4.5); 2.3846 (4.2); 2.3676 (4.0); 2.3419 (9.4); 2.3329 (1.0); 2.3193 (9.3); 2.3108 (4.5); 2.3022 (8.3); 2.2970 (5.3); 2.2864 (6.6); 2.2796 (8.3); 2.2725 (6.7); 2.2559 (1.7); 2.2447 (3.7); 2.2317 (4.1); 2.2152 (2.8); 2.1969 (3.5); 2.1911 (1.8); 2.1845 (3.1); 2.1790 (2.7); 2.1723 (2.6); 2.1661 (4.1); 2.1603 (2.6); 2.1547 (1.8); 2.1471 (2.7); 2.1412 (2.8); 2.1228 (1.6); 2.0720 (2.4); 1.7470 (2.0); 1.7350 (3.3); 1.7235 (4.1); 1.7160 (2.6); 1.7124 (3.3); 1.7041 (3.8); 1.6991 (2.6); 1.6919 (3.8); 1.6805 (2.5); 1.6672 (1.7) I.1-023: 1 H-NMR (400.1 MHz, CDCl 3 ): δ= 7.5210 (0.4); 7.3865 (5.6); 7.3669 (8.7); 7.3136 (4.4); 7.2954 (8.2); 7.2754 (4.8); 7.2620 (76.5); 7.2333 (3.1); 7.2148 (4.0); 7.1968 (1.3); 7.1220 (0.5); 7.1099 (1.0); 7.0976 (1.9); 7.0867 (1.3); 7.0799 (1.9); 7.0718 (2.2); 7.0511 (5.0); 7.0477 (5.1); 7.0383 (6.7); 7.0281 (3.3); 7.0099 (0.4); 6.9980 (0.5); 4.8708 (3.2); 4.8318 (3.5); 4.2556 (5.6); 4.2388 (16.0); 4.2218 (6.2); 4.2007 (3.9); 3.8722 (0.6); 3.8621 (1.2); 3.8512 (1.9); 3.8409 (2.3); 3.8306 (2.0); 3.8198 (1.4); 3.8096 (0.7); 3.1305 (6.0); 3.1136 (12.0); 3.0967 (5.8); 2.6841 (2.6); 2.6742 (2.7); 2.6453 (3.3); 2.6353 (3.4); 2.5356 (0.7); 2.5178 (0.9); 2.5119 (0.9); 2.4930 (2.2); 2.4744 (1.9); 2.4692 (2.0); 2.4509 (1.8); 2.4237 (1.7); 2.4092 (1.9); 2.3992 (2.4); 2.3848 (2.6); 2.3779 (4.0); 2.3667 (1.0); 2.3558 (4.4); 2.3390 (3.1); 2.3168 (2.6); 2.2951 (1.0); 2.2760 (1.5); 2.2716 (1.0); 2.2628 (1.2); 2.2577 (1.1); 2.2517 (1.2); 2.2433 (1.7); 2.2387 (1.2); 2.2333 (0.8); 2.2246 (1.0); 2.2189 (1.3); 2.2002 (0.6); 1.8500 (0.8); 1.8371 (1.3); 1.8255 (1.5); 1.8155 (1.5); 1.8043 (1.4); 1.7931 (1.4); 1.7810 (1.0); 1.7679 (0.7); 1.5958 (37.9); 1.2550 (0.5) I.1-024: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.3813 (0.9); 7.3773 (1.0); 7.3609 (1.9); 7.3568 (2.1); 7.3507 (1.1); 7.3411 (1.3); 7.3351 (2.1); 7.3307 (1.8); 7.3147 (1.1); 7.3106 (1.1); 7.2095 (1.2); 7.2055 (1.3); 7.1968 (1.2); 7.1929 (1.4); 7.1896 (2.2); 7.1858 (2.4); 7.1769 (2.2); 7.1733 (2.4); 7.1693 (1.5); 7.1653 (1.5); 7.1565 (1.3); 7.1529 (1.4); 7.0992 (2.2); 7.0834 (2.9); 7.0798 (2.7); 7.0639 (1.5); 4.7341 (3.2); 4.6941 (3.9); 4.6676 (15.7); 4.6668 (15.5); 4.6615 (15.9); 4.6606 (15.6); 4.2611 (4.4); 4.2213 (3.8); 4.0208 (1.0); 4.0031 (1.0); 3.8310 (0.9); 3.8206 (1.6); 3.8102 (2.4); 3.8001 (2.7); 3.7900 (2.4); 3.7797 (1.9); 3.7694 (1.0); 3.6357 (7.1); 3.5480 (7.2); 3.5418 (16.0); 3.5357 (6.8); 3.1674 (2.2); 2.8446 (3.4); 2.8344 (3.4); 2.8044 (4.6); 2.7942 (4.3); 2.6744 (0.7); 2.6698 (1.0); 2.6651 (0.8); 2.5908 (4.9); 2.5695 (4.8); 2.5507 (4.1); 2.5458 (0.6); 2.5400 (0.8); 2.5293 (4.0); 2.5233 (2.6); 2.5186 (3.5); 2.5099 (49.2); 2.5053 (105.4); 2.5007 (146.4); 2.4960 (102.8); 2.4915 (46.3); 2.4757 (0.6); 2.4646 (1.1); 2.4477 (1.1); 2.4385 (0.7); 2.4236 (2.5); 2.4059 (2.2); 2.4007 (2.0); 2.3922 (0.8); 2.3846 (1.0); 2.3692 (0.6); 2.3322 (0.8); 2.3275 (1.0); 2.3228 (0.7); 2.2919 (1.7); 2.2796 (1.8); 2.2673 (3.1); 2.2551 (3.1); 2.2259 (4.6); 2.2167 (2.7); 2.2137 (2.3); 2.2040 (1.8); 2.1980 (1.4); 2.1929 (0.8); 2.1859 (2.2); 2.1794 (1.1); 2.1734 (0.8); 2.1665 (1.4); 2.1606 (1.3); 2.1419 (0.8); 2.0720 (1.0); 1.7875 (0.5); 1.7619 (2.0); 1.7506 (1.6); 1.7399 (2.3); 1.7326 (1.2); 1.7276 (1.2); 1.7229 (1.2); 1.7186 (1.3); 1.7081 (1.3); 1.6960 (0.9); 1.1543 (1.3); 1.1365 (2.6); 1.1187 (1.2); 0.0080 (0.6); - 0.0002 (22.9); -0.0085 (0.6) I.1-025: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 7.3828 (2.8); 7.3788 (3.0); 7.3623 (5.7); 7.3582 (6.3); 7.3522 (3.3); 7.3425 (4.0); 7.3363 (6.2); 7.3321 (5.4); 7.3160 (3.4); 7.3121 (3.3); 7.2091 (3.6); 7.2051 (3.8); 7.1964 (3.8); 7.1924 (4.4); 7.1892 (6.6); 7.1854 (7.0); 7.1765 (6.5); 7.1729 (7.2); 7.1689 (4.4); 7.1649 (4.2); 7.1561 (3.7); 7.1524 (4.0); 7.0886 (6.8); 7.0727 (9.1); 7.0692 (8.3); 7.0531 (4.7); 4.8884 (2.2); 4.8863 (2.3); 4.8687 (8.7); 4.8510 (12.0); 4.8490 (12.2); 4.8313 (8.8); 4.8137 (2.3); 4.8114 (2.2); 4.7146 (10.2); 4.6748 (12.1); 4.2630 (13.4); 4.2231 (11.4); 3.8305 (0.9); 3.8233 (2.4); 3.8124 (5.2); 3.8029 (6.4); 3.7924 (8.6); 3.7825 (5.8); 3.7724 (4.7); 3.7616 (1.9); 3.3641 (1.6); 3.3429 (0.8); 3.3388 (1.2); 3.3339 (2.4); 3.3147 (672.4); 3.2910 (17.4); 3.2631 (0.7); 3.1761 (0.6); 3.1629 (0.6); 2.7359 (10.9); 2.7251 (11.0); 2.6960 (15.2); 2.6852 (14.5); 2.6749 (1.3); 2.6703 (1.5); 2.6657 (1.0); 2.5459 (0.8); 2.5405 (1.1); 2.5238 (3.8); 2.5191 (5.7); 2.5105 (82.5); 2.5058 (163.7); 2.5012 (225.8); 2.4966 (159.3); 2.4919 (85.2); 2.4797 (1.4); 2.4720 (11.9); 2.4516 (11.4); 2.4408 (3.1); 2.4316 (0.9); 2.4234 (3.5); 2.4141 (2.2); 2.3997 (7.8); 2.3821 (6.1); 2.3762 (5.5); 2.3650 (2.5); 2.3600 (2.9); 2.3435 (1.2); 2.3374 (0.6); 2.3326 (1.2); 2.3280 (1.8); 2.3234 (1.1); 2.3188 (0.5); 2.2958 (5.5); 2.2827 (6.1); 2.2712 (9.9); 2.2630 (5.6); 2.2582 (11.2); 2.2486 (4.3); 2.2450 (5.7); 2.2428 (7.6); 2.2385 (9.3); 2.2365 (9.1); 2.2323 (11.8); 2.2301 (13.6); 2.2255 (15.7); 2.2185 (15.1); 2.2145 (13.2); 2.2125 (16.0); 2.2081 (9.3); 2.2059 (8.0); 2.2024 (9.7); 2.1947 (8.7); 2.1880 (8.2); 2.1847 (6.8); 2.1781 (3.3); 2.1721 (2.3); 2.1651 (4.1); 2.1588 (3.5); 2.1405 (2.1); 2.0724 (0.7); 1.9896 (0.6); 1.9858 (2.2); 1.9800 (1.4); 1.9770 (2.7); 1.9700 (2.1); 1.9663 (3.1); 1.9608 (6.7); 1.9572 (4.7); 1.9551 (5.1); 1.9522 (7.9); 1.9452 (5.4); 1.9413 (6.6); 1.9359 (8.2); 1.9327 (9.2); 1.9302 (8.0); 1.9272 (8.3); 1.9214 (5.6); 1.9171 (5.3); 1.9106 (7.0); 1.9079 (6.8); 1.9058 (5.4); 1.9022 (5.4); 1.8967 (3.1); 1.8931 (2.2); 1.8859 (3.3); 1.8806 (1.1); 1.8773 (2.3); 1.8733 (0.6); 1.7838 (1.0); 1.7620 (2.9); 1.7562 (7.6); 1.7515 (3.9); 1.7492 (3.8); 1.7450 (7.9); 1.7374 (4.3); 1.7315 (9.9); 1.7269 (8.7); 1.7246 (9.8); 1.7219 (7.6); 1.7178 (5.8); 1.7155 (6.7); 1.7092 (2.9); 1.7067 (5.1); 1.7023 (7.0); 1.7000 (10.3); 1.6976 (7.2); 1.6932 (4.5); 1.6905 (4.8); 1.6821 (1.6); 1.6797 (1.6); 1.6753 (2.5); 1.6729 (2.5); 1.6685 (1.3); 1.6661 (1.2); 1.6268 (3.0); 1.6068 (5.3); 1.6018 (5.8); 1.5866 (3.4); 1.5816 (11.1); 1.5766 (4.0); 1.5749 (5.1); 1.5615 (5.5); 1.5597 (3.6); 1.5564 (6.0); 1.5547 (8.5); 1.5497 (2.4); 1.5362 (2.9); 1.5345 (3.9); 1.5295 (3.2); 1.5093 (1.5); 0.0079 (0.6); -0.0002 (19.9); -0.0085 (0.5) I.1-026: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.3625 (1.0); 7.3584 (1.1); 7.3524 (0.6); 7.3427 (0.7); 7.3365 (1.0); 7.3324 (0.9); 7.3162 (0.6); 7.3123 (0.6); 7.2101 (0.6); 7.2061 (0.6); 7.1974 (0.6); 7.1934 (0.7); 7.1901 (1.1); 7.1863 (1.2); 7.1775 (1.1); 7.1738 (1.2); 7.1698 (0.8); 7.1658 (0.7); 7.1570 (0.6); 7.1533 (0.7); 7.0898 (1.1); 7.0739 (1.6); 7.0704 (1.4); 7.0544 (0.8); 4.8813 (0.9); 4.8657 (2.5); 4.8500 (3.5); 4.8344 (2.6); 4.8187 (1.0); 4.7207 (1.7); 4.6810 (2.0); 4.2640 (2.3); 4.2241 (1.9); 3.8189 (0.8); 3.8094 (1.1); 3.7989 (1.5); 3.7888 (1.0); 3.7789 (0.8); 3.4236 (20.1); 3.1686 (1.0); 2.7196 (2.0); 2.7088 (2.0); 2.6801 (2.8); 2.6749 (0.5); 2.6694 (2.8); 2.5237 (0.7); 2.5190 (1.1); 2.5104 (19.1); 2.5058 (41.5); 2.5012 (57.3); 2.4965 (40.0); 2.4919 (18.4); 2.4689 (2.9); 2.4498 (2.1); 2.4294 (2.1); 2.4242 (0.7); 2.4000 (1.4); 2.3821 (1.0); 2.3762 (0.9); 2.3599 (0.5); 2.2992 (1.0); 2.2859 (1.1); 2.2746 (1.7); 2.2615 (1.6); 2.2332 (1.2); 2.2292 (1.3); 2.2270 (1.3); 2.2216 (0.9); 2.2179 (0.8); 2.2145 (1.0); 2.2042 (0.9); 2.1984 (0.7); 2.1866 (1.0); 2.1797 (0.6); 2.1669 (0.7); 2.1603 (0.6); 1.7586 (1.1); 1.7473 (1.1); 1.7400 (0.6); 1.7339 (1.0); 1.7292 (0.6); 1.7233 (0.6); 1.7173 (0.8); 1.7047 (0.6); 1.1496 (16.0); 1.1465 (15.9); 1.1340 (15.8); 1.1309 (15.9); -0.0002 (1.0) I.1-027: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 7.3813 (1.0); 7.3609 (2.1); 7.3383 (2.1); 7.3352 (2.0); 7.3147 (1.1); 7.2100 (1.1); 7.2064 (1.2); 7.1973 (1.2); 7.1898 (2.2); 7.1866 (2.3); 7.1770 (2.1); 7.1740 (2.4); 7.1661 (1.3); 7.1570 (1.1); 7.1536 (1.3); 7.0890 (2.3); 7.0730 (3.1); 7.0537 (1.5); 5.7926 (0.9); 5.7759 (1.9); 5.7670 (0.9); 5.7592 (0.9); 5.7501 (2.8); 5.7330 (2.8); 5.7239 (1.0); 5.7161 (1.0); 5.7072 (2.2); 5.6904 (1.0); 5.1063 (1.3); 5.1023 (3.2); 5.0974 (3.7); 5.0935 (1.5); 5.0632 (1.2); 5.0593 (2.9); 5.0543 (3.6); 5.0500 (4.2); 5.0470 (2.2); 5.0448 (2.8); 5.0418 (1.3); 5.0273 (1.4); 5.0242 (3.1); 5.0213 (2.0); 5.0192 (2.6); 5.0161 (1.1); 4.8686 (1.1); 4.8508 (1.5); 4.8488 (1.5); 4.8311 (1.1); 4.7250 (2.4); 4.7144 (1.3); 4.6854 (2.8); 4.6742 (1.6); 4.2566 (3.5); 4.2167 (3.0); 4.0464 (5.8); 4.0299 (13.0); 4.0134 (6.4); 3.8183 (0.8); 3.8119 (1.0); 3.8074 (1.4); 3.7976 (2.0); 3.7919 (1.8); 3.7874 (2.5); 3.7818 (1.5); 3.7774 (1.9); 3.7721 (1.3); 3.7673 (1.5); 3.7609 (0.8); 3.7568 (0.8); 3.5904 (16.0); 3.1680 (2.5); 2.7609 (2.4); 2.7502 (2.5); 2.7355 (1.3); 2.7245 (1.7); 2.7211 (3.5); 2.7105 (3.3); 2.6956 (2.0); 2.6848 (1.8); 2.6746 (0.7); 2.6700 (1.0); 2.6653 (0.8); 2.6000 (0.5); 2.5234 (2.1); 2.5206 (4.7); 2.5102 (54.9); 2.5056 (118.5); 2.5009 (165.6); 2.4963 (114.3); 2.4917 (53.2); 2.4810 (3.6); 2.4718 (1.4); 2.4601 (2.8); 2.4549 (1.3); 2.4507 (3.1); 2.4455 (2.5); 2.4415 (2.1); 2.4249 (1.4); 2.4164 (1.1); 2.4074 (0.8); 2.4011 (2.6); 2.3834 (2.0); 2.3790 (1.9); 2.3612 (1.2); 2.3324 (0.8); 2.3277 (1.0); 2.3230 (0.8); 2.3140 (1.2); 2.3105 (1.9); 2.3071 (1.2); 2.2974 (3.8); 2.2939 (7.0); 2.2906 (4.0); 2.2807 (4.9); 2.2774 (6.1); 2.2739 (3.8); 2.2686 (3.0); 2.2640 (1.8); 2.2606 (2.6); 2.2561 (3.7); 2.2428 (1.1); 2.2385 (1.3); 2.2365 (1.2); 2.2322 (1.5); 2.2267 (3.2); 2.2189 (3.7); 2.2152 (2.7); 2.2124 (2.4); 2.2076 (2.1); 2.1941 (2.1); 2.1878 (2.0); 2.1830 (1.4); 2.1758 (1.7); 2.1691 (1.0); 2.1642 (1.0); 2.1562 (1.2); 2.1499 (1.0); 2.1316 (0.6); 2.0721 (1.2); 1.9607 (0.8); 1.9549 (0.6); 1.9521 (1.0); 1.9451 (0.7); 1.9412 (0.8); 1.9358 (1.0); 1.9325 (1.1); 1.9301 (1.0); 1.9271 (1.0); 1.9213 (0.7); 1.9170 (0.7); 1.9104 (0.9); 1.9077 (0.8); 1.9021 (0.7); 1.7623 (1.0); 1.7553 (2.1); 1.7492 (0.7); 1.7437 (2.2); 1.7315 (2.4); 1.7270 (2.0); 1.7248 (2.1); 1.7200 (1.5); 1.7131 (1.7); 1.7067 (0.8); 1.7001 (2.2); 1.6932 (0.7); 1.6882 (0.9); 1.6067 (0.7); 1.6017 (0.7); 1.5815 (1.4); 1.5748 (0.6); 1.5614 (0.7); 1.5546 (1.1); 1.5345 (0.5); 0.0080 (0.6); 0.0023 (0.7); -0.0002 (20.5); -0.0085 (0.6) I.1-028: 1 H-NMR (400.1 MHz, CDCl3): δ= 7.5188 (1.2); 7.3157 (1.4); 7.3097 (10.2); 7.3076 (4.4); 7.3043 (3.9); 7.2974 (2.1); 7.2913 (14.0); 7.2879 (13.8); 7.2820 (2.6); 7.2781 (1.3); 7.2745 (5.0); 7.2715 (6.0); 7.2694 (14.2); 7.2668 (3.9); 7.2659 (4.2); 7.2600 (208.0); 7.2535 (3.8); 7.2526 (3.2); 7.2510 (2.2); 7.2501 (1.9); 7.2493 (1.7); 7.2485 (1.5); 7.2476 (1.3); 7.2468 (1.3); 7.2461 (1.1); 7.2452 (1.0); 7.2444 (0.9); 7.2436 (0.9); 7.2428 (0.8); 7.2420 (0.7); 7.2411 (0.7); 7.2403 (0.7); 7.2395 (0.6); 7.2387 (0.5); 7.2379 (0.4); 7.2370 (0.4); 7.2362 (0.4); 7.2354 (0.4); 7.2338 (0.3); 7.1133 (1.1); 7.1030 (1.4); 7.0982 (1.9); 7.0957 (1.3); 7.0882 (3.6); 7.0783 (2.6); 7.0703 (4.1); 7.0641 (4.0); 7.0590 (4.0); 7.0472 (15.9); 7.0374 (15.1); 7.0324 (4.4); 7.0289 (5.9); 7.0220 (4.1); 7.0132 (0.6); 7.0025 (0.8); 6.9951 (3.3); 6.9925 (5.8); 6.9898 (3.5); 6.9762 (4.2); 6.9741 (9.8); 6.9720 (4.8); 6.9583 (2.5); 6.9556 (4.6); 6.9530 (2.7); 6.9098 (2.0); 6.9079 (2.4); 6.9044 (12.8); 6.9017 (16.0); 6.8997 (8.1); 6.8964 (4.4); 6.8874 (4.3); 6.8850 (7.2); 6.8824 (13.8); 6.8799 (11.8); 6.8735 (1.5); 4.8834 (4.9); 4.8796 (5.0); 4.8446 (5.6); 4.8407 (5.7); 4.4396 (9.1); 4.4333 (4.3); 4.4286 (10.7); 4.4247 (8.2); 4.4219 (4.6); 4.4161 (13.5); 4.2610 (8.0); 4.2221 (7.2); 4.1668 (14.2); 4.1617 (4.4); 4.1577 (8.4); 4.1548 (13.8); 4.1490 (4.2); 4.1434 (11.6); 3.9179 (1.2); 3.9070 (2.3); 3.8965 (3.4); 3.8861 (3.9); 3.8759 (3.4); 3.8655 (2.5); 3.8548 (1.3); 3.6679 (9.8); 3.4895 (0.4); 2.7731 (5.7); 2.7630 (5.8); 2.7342 (7.5); 2.7241 (7.3); 2.6981 (0.7); 2.6876 (0.7); 2.5477 (1.2); 2.5460 (1.2); 2.5299 (1.6); 2.5281 (1.6); 2.5234 (1.5); 2.5215 (1.5); 2.5048 (3.7); 2.4853 (3.6); 2.4802 (10.6); 2.4583 (8.3); 2.4412 (6.4); 2.4225 (4.3); 2.4194 (6.8); 2.4144 (1.9); 2.4082 (4.0); 2.3980 (5.6); 2.3837 (5.1); 2.3799 (2.2); 2.3759 (1.0); 2.3712 (0.5); 2.3656 (1.5); 2.3551 (2.8); 2.3412 (2.8); 2.3045 (2.2); 2.2850 (2.7); 2.2801 (1.7); 2.2723 (2.6); 2.2671 (2.2); 2.2605 (2.1); 2.2542 (3.0); 2.2526 (2.8); 2.2477 (2.1); 2.2427 (1.5); 2.2344 (2.1); 2.2279 (2.1); 2.2099 (1.4); 2.1326 (1.7); 2.0912 (2.6); 2.0041 (1.3); 1.8820 (1.8); 1.8707 (2.0); 1.8684 (2.3); 1.8575 (2.9); 1.8496 (2.3); 1.8469 (2.4); 1.8440 (2.2); 1.8380 (2.2); 1.8359 (2.4); 1.8326 (2.1); 1.8246 (2.5); 1.8140 (1.7); 1.8113 (1.6); 1.7997 (1.4); 1.5592 (12.2); 1.4369 (0.9); 1.4227 (0.9); 1.2845 (0.6); 1.2554 (2.0); 0.8800 (0.4); 0.8456 (0.4); 0.8358 (0.5); 0.0081 (1.1); 0.0061 (0.6); 0.0000 (36.6) I.1-029: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.3630 (0.9); 7.3589 (1.0); 7.3528 (0.5); 7.3432 (0.6); 7.3370 (1.0); 7.3328 (0.9); 7.3168 (0.5); 7.3127 (0.5); 7.2091 (0.6); 7.2051 (0.6); 7.1964 (0.6); 7.1924 (0.7); 7.1892 (1.1); 7.1854 (1.1); 7.1765 (1.0); 7.1729 (1.2); 7.1688 (0.7); 7.1648 (0.7); 7.1561 (0.6); 7.1524 (0.6); 7.0919 (1.0); 7.0756 (1.4); 7.0566 (0.7); 4.8077 (0.5); 4.8010 (0.7); 4.7920 (0.8); 4.7897 (0.7); 4.7870 (0.7); 4.7846 (0.8); 4.7780 (0.7); 4.7757 (0.7); 4.7690 (0.5); 4.7311 (1.6); 4.6913 (1.9); 4.2601 (1.6); 4.2202 (1.3); 3.8119 (0.7); 3.8021 (1.0); 3.7918 (1.3); 3.7818 (1.0); 3.7717 (0.7); 3.4307 (10.7); 3.1680 (0.7); 2.7543 (1.0); 2.7474 (1.0); 2.7437 (1.1); 2.7369 (1.0); 2.7149 (1.3); 2.7080 (1.4); 2.7043 (1.3); 2.6976 (1.2); 2.5500 (0.6); 2.5454 (0.6); 2.5403 (0.6); 2.5236 (0.9); 2.5188 (1.2); 2.5102 (17.0); 2.5056 (36.3); 2.5010 (50.3); 2.4963 (35.4); 2.4918 (16.7); 2.4781 (1.4); 2.4717 (1.2); 2.4594 (0.8); 2.4533 (0.6); 2.4388 (1.3); 2.4322 (1.2); 2.4222 (0.5); 2.4061 (0.7); 2.3989 (0.6); 2.3815 (0.9); 2.3010 (0.6); 2.2881 (0.7); 2.2775 (1.0); 2.2761 (1.0); 2.2632 (1.2); 2.2347 (0.7); 2.2280 (1.4); 2.2153 (0.6); 2.2124 (0.8); 2.2018 (0.8); 2.1961 (0.6); 2.1838 (0.8); 2.1644 (0.6); 2.1581 (0.5); 1.7478 (0.7); 1.7456 (0.6); 1.7339 (0.8); 1.7233 (0.6); 1.7176 (0.8); 1.7034 (0.7); 1.4766 (0.6); 1.4665 (0.5); 1.4625 (0.8); 1.4575 (0.9); 1.4531 (0.8); 1.4480 (0.8); 1.4433 (1.1); 1.4389 (1.0); 1.4347 (0.9); 1.4307 (0.8); 1.4246 (1.1); 1.4203 (1.0); 1.4169 (0.6); 1.4118 (0.9); 1.4089 (0.9); 1.4049 (0.7); 1.3954 (0.7); 1.3912 (0.8); 1.2861 (0.6); 1.2757 (0.6); 1.2723 (0.7); 1.2675 (0.7); 1.2639 (0.9); 1.2574 (0.9); 1.2537 (0.9); 1.2489 (0.9); 1.2456 (0.9); 1.2395 (1.1); 1.2351 (0.8); 1.2309 (1.0); 1.2218 (1.0); 1.2133 (0.7); 1.2056 (0.5); 1.1247 (8.4); 1.1178 (8.5); 1.1091 (8.4); 1.1021 (8.4); 0.8641 (7.1); 0.8458 (16.0); 0.8275 (5.8); -0.0002 (12.0) I.1-031: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 7.3833 (0.6); 7.3793 (0.6); 7.3629 (1.2); 7.3588 (1.4); 7.3527 (0.7); 7.3431 (0.9); 7.3370 (1.3); 7.3327 (1.2); 7.3166 (0.7); 7.3126 (0.7); 7.2098 (0.8); 7.2059 (0.8); 7.1972 (0.8); 7.1932 (0.9); 7.1899 (1.4); 7.1862 (1.5); 7.1773 (1.4); 7.1736 (1.5); 7.1696 (0.9); 7.1656 (0.9); 7.1569 (0.8); 7.1532 (0.9); 7.0943 (1.3); 7.0781 (1.8); 7.0598 (0.9); 4.7399 (1.6); 4.7332 (2.7); 4.7247 (2.0); 4.7173 (1.9); 4.7090 (1.9); 4.7014 (2.3); 4.6935 (3.0); 4.6861 (1.1); 4.2622 (2.8); 4.2224 (2.4); 3.8145 (0.9); 3.8046 (1.4); 3.7943 (1.7); 3.7843 (1.3); 3.7741 (1.0); 3.4668 (16.0); 3.1680 (1.2); 2.7597 (1.3); 2.7546 (1.4); 2.7492 (1.4); 2.7442 (1.3); 2.7203 (1.8); 2.7154 (1.8); 2.7098 (1.8); 2.7049 (1.7); 2.5235 (1.2); 2.5188 (1.7); 2.5102 (28.0); 2.5056 (61.7); 2.5010 (84.6); 2.4963 (57.8); 2.4917 (26.1); 2.4843 (2.6); 2.4798 (2.1); 2.4657 (1.5); 2.4613 (1.4); 2.4449 (1.5); 2.4404 (1.7); 2.4231 (0.6); 2.4066 (0.9); 2.3999 (0.9); 2.3890 (0.7); 2.3825 (1.2); 2.3766 (0.7); 2.3656 (0.6); 2.3278 (0.6); 2.3000 (0.8); 2.2868 (0.9); 2.2775 (1.3); 2.2753 (1.3); 2.2623 (1.5); 2.2338 (1.0); 2.2292 (1.7); 2.2177 (1.0); 2.2144 (1.1); 2.2039 (1.1); 2.1982 (0.8); 2.1865 (1.2); 2.1794 (0.7); 2.1667 (0.8); 2.1601 (0.7); 2.0722 (0.5); 1.7639 (0.7); 1.7531 (1.2); 1.7420 (1.2); 1.7348 (0.8); 1.7288 (0.9); 1.7232 (0.8); 1.7112 (0.8); 1.6975 (0.6); 1.5145 (1.1); 1.4958 (4.0); 1.4799 (4.5); 1.4773 (4.7); 1.4614 (4.4); 1.4429 (1.4); 1.1223 (12.5); 1.1159 (12.5); 1.1066 (12.4); 1.1002 (12.4); 0.8300 (5.2); 0.8261 (5.2); 0.8115 (11.2); 0.8076 (11.2); 0.7927 (4.8); 0.7889 (4.7); -0.0002 (15.5) I.1-032: 1 H-NMR (400.1 MHz, CDCl3): δ= 7.2680 (0.4); 7.2603 (39.0); 7.0907 (0.4); 7.0728 (0.5); 7.0665 (0.5); 7.0597 (0.6); 7.0495 (1.9); 7.0401 (1.8); 7.0350 (0.6); 7.0316 (0.6); 7.0245 (0.4); 6.8313 (16.0); 4.8857 (0.6); 4.8816 (0.6); 4.8469 (0.7); 4.8429 (0.6); 4.4111 (1.0); 4.3996 (1.1); 4.3963 (0.8); 4.3876 (1.4); 4.2610 (1.0); 4.2222 (0.9); 4.1134 (1.5); 4.1081 (0.4); 4.1043 (0.9); 4.1015 (1.4); 4.0958 (0.4); 4.0900 (1.2); 3.8992 (0.4); 3.8890 (0.4); 3.8787 (0.4); 3.7686 (12.8); 3.6680 (2.6); 2.7755 (0.6); 2.7654 (0.6); 2.7366 (0.9); 2.7264 (0.9); 2.5062 (0.4); 2.4847 (1.1); 2.4629 (1.1); 2.4458 (0.7); 2.4240 (1.1); 2.4143 (0.4); 2.4098 (0.4); 2.3995 (0.7); 2.3852 (0.6); 2.3567 (0.4); 2.2548 (0.3); 1.8604 (0.4); 1.5522 (4.2) I.1-034: 1 H-NMR (400.1 MHz, CDCl3): δ= 7.9307 (12.0); 7.9106 (13.3); 7.9065 (7.9); 7.7014 (2.1); 7.6982 (2.3); 7.6848 (4.4); 7.6802 (6.4); 7.6747 (1.8); 7.6642 (4.7); 7.6610 (4.7); 7.6578 (2.1); 7.6051 (9.0); 7.6002 (3.2); 7.5875 (11.4); 7.5846 (11.3); 7.5701 (4.4); 7.5664 (5.0); 7.5194 (1.0); 7.3621 (0.5); 7.3183 (0.7); 7.2675 (73.0); 7.2657 (73.4); 7.2606 (172.6); 7.2381 (0.6); 7.2185 (0.6); 7.1331 (1.1); 7.1262 (1.1); 7.1152 (3.0); 7.1090 (2.9); 7.0960 (4.3); 7.0900 (3.3); 7.0840 (3.7); 7.0784 (3.4); 7.0729 (3.1); 7.0658 (5.5); 7.0595 (7.1); 7.0479 (11.7); 7.0394 (9.2); 7.0351 (7.8); 7.0161 (1.3); 6.9966 (1.0); 4.8916 (1.1); 4.8402 (5.6); 4.8014 (6.3); 4.4350 (8.1); 4.4201 (16.0); 4.4050 (8.5); 4.2634 (1.3); 4.2238 (1.2); 4.1828 (6.4); 4.1441 (5.7); 3.8839 (0.9); 3.8741 (0.6); 3.8633 (0.4); 3.8159 (1.0); 3.8053 (1.9); 3.7944 (3.0); 3.7845 (3.4); 3.7739 (2.9); 3.7632 (2.0); 3.7530 (1.0); 3.6747 (5.3); 3.6682 (11.4); 3.4911 (0.6); 3.4383 (9.0); 3.4238 (15.1); 3.4084 (8.1); 2.7371 (0.8); 2.7271 (0.8); 2.6983 (1.0); 2.6883 (0.9); 2.5468 (3.9); 2.5370 (4.0); 2.5127 (4.2); 2.5074 (5.4); 2.4974 (6.1); 2.4704 (3.8); 2.4512 (4.1); 2.4462 (3.1); 2.4369 (1.8); 2.4278 (3.3); 2.4151 (4.2); 2.4002 (4.5); 2.3908 (3.6); 2.3764 (4.9); 2.3577 (1.4); 2.3480 (1.7); 2.3337 (1.6); 2.3168 (0.4); 2.2990 (0.6); 2.2761 (1.7); 2.2475 (6.5); 2.2384 (2.4); 2.2318 (4.7); 2.2255 (7.8); 2.2196 (2.3); 2.2078 (5.4); 2.2011 (2.2); 2.1861 (4.3); 2.1339 (1.2); 2.1014 (1.6); 2.0945 (3.8); 2.0048 (1.0); 1.8647 (0.5); 1.8514 (0.5); 1.8429 (0.6); 1.8325 (0.6); 1.8194 (0.4); 1.8083 (0.3); 1.7845 (1.3); 1.7731 (1.9); 1.7603 (2.4); 1.7517 (2.5); 1.7405 (2.4); 1.7280 (1.9); 1.7163 (1.6); 1.7021 (1.0); 1.6582 (0.3); 1.5562 (20.6); 1.4778 (0.4); 1.4380 (0.7); 1.4236 (0.9); 1.3335 (0.9); 1.3206 (0.6); 1.3094 (0.8); 1.2847 (1.6); 1.2607 (3.9); 1.1827 (0.4); 1.0873 (0.3); 1.0523 (0.4); 0.9215 (0.3); 0.8948 (0.7); 0.8820 (1.2); 0.8531 (2.0); 0.8367 (2.2); 0.0154 (0.4); 0.0069 (12.3); 0.0051 (12.5); 0.0000 (29.8) I.1-035: 1 H-NMR (400.1 MHz, CDCl3): δ= 7.5192 (0.9); 7.2837 (0.4); 7.2828 (0.4); 7.2820 (0.4); 7.2812 (0.4); 7.2804 (0.5); 7.2797 (0.4); 7.2771 (0.7); 7.2763 (0.7); 7.2755 (0.8); 7.2747 (0.9); 7.2730 (1.2); 7.2722 (1.4); 7.2605 (167.0); 7.2517 (16.6); 7.2460 (5.3); 7.2402 (1.2); 7.2347 (5.7); 7.2290 (17.3); 7.2205 (1.7); 7.2102 (1.3); 7.1613 (0.3); 7.1173 (0.7); 7.1074 (0.7); 7.1024 (1.4); 7.0923 (2.2); 7.0825 (1.5); 7.0744 (2.7); 7.0681 (2.5); 7.0624 (2.1); 7.0594 (2.0); 7.0520 (9.4); 7.0507 (8.9); 7.0420 (9.5); 7.0369 (3.0); 7.0336 (3.7); 7.0265 (2.6); 7.0176 (0.4); 7.0071 (0.4); 6.9965 (0.9); 6.8412 (1.8); 6.8326 (16.0); 6.8269 (4.7); 6.8156 (4.9); 6.8099 (14.2); 6.8013 (1.3); 4.8846 (3.2); 4.8806 (3.0); 4.8458 (3.6); 4.8418 (3.4); 4.4266 (6.6); 4.4206 (3.1); 4.4151 (7.4); 4.4118 (5.0); 4.4085 (3.1); 4.4031 (8.3); 4.2569 (4.6); 4.2181 (4.2); 4.1316 (8.6); 4.1263 (3.1); 4.1227 (5.5); 4.1197 (8.2); 4.1138 (2.8); 4.1082 (7.0); 3.9164 (0.8); 3.9057 (1.5); 3.8954 (2.2); 3.8850 (2.7); 3.8747 (2.2); 3.8643 (1.6); 3.8538 (0.8); 3.6681 (7.0); 2.7712 (3.5); 2.7611 (3.5); 2.7323 (4.7); 2.7221 (4.5); 2.6982 (0.5); 2.6879 (0.5); 2.5475 (0.7); 2.5295 (1.0); 2.5276 (1.0); 2.5232 (0.9); 2.5211 (0.8); 2.5047 (2.4); 2.4927 (5.4); 2.4866 (2.3); 2.4804 (2.0); 2.4787 (2.0); 2.4712 (5.1); 2.4624 (2.0); 2.4537 (4.0); 2.4364 (1.1); 2.4322 (4.0); 2.4259 (2.4); 2.4116 (2.6); 2.4013 (3.3); 2.3871 (3.2); 2.3831 (1.3); 2.3759 (0.7); 2.3690 (1.0); 2.3584 (1.8); 2.3445 (1.7); 2.3043 (1.3); 2.2848 (1.8); 2.2798 (1.2); 2.2720 (1.7); 2.2667 (1.5); 2.2602 (1.4); 2.2539 (1.8); 2.2522 (1.8); 2.2474 (1.5); 2.2423 (1.0); 2.2340 (1.4); 2.2293 (1.2); 2.2276 (1.3); 2.2094 (0.8); 2.1335 (1.4); 2.0926 (1.2); 2.0047 (1.0); 1.8813 (1.1); 1.8701 (1.3); 1.8676 (1.4); 1.8569 (1.8); 1.8490 (1.4); 1.8462 (1.6); 1.8433 (1.5); 1.8375 (1.5); 1.8350 (1.5); 1.8319 (1.4); 1.8238 (1.6); 1.8134 (1.1); 1.8106 (1.0); 1.7990 (0.9); 1.5557 (14.2); 1.4376 (0.7); 1.4234 (0.7); 1.2846 (0.4); 1.2552 (1.1); 0.8362 (0.3); 0.8313 (0.3); 0.0082 (1.0) I.1-036: 1 H-NMR (400.1 MHz, CDCl3): δ= 7.2694 (0.4); 7.2686 (0.4); 7.2600 (56.2); 7.1138 (0.4); 7.0988 (0.9); 7.0919 (3.4); 7.0903 (4.1); 7.0890 (3.6); 7.0757 (1.6); 7.0702 (5.4); 7.0687 (4.6); 7.0644 (2.0); 7.0590 (1.6); 7.0468 (5.0); 7.0369 (4.6); 7.0323 (1.5); 7.0286 (1.8); 7.0218 (1.3); 6.9961 (0.4); 6.8046 (0.6); 6.7972 (5.5); 6.7920 (1.9); 6.7809 (1.6); 6.7757 (4.9); 6.7684 (0.6); 4.8815 (1.4); 4.8778 (1.5); 4.8428 (1.6); 4.8390 (1.7); 4.4208 (2.8); 4.4145 (1.3); 4.4093 (3.2); 4.4061 (2.4); 4.4035 (1.5); 4.3974 (3.9); 4.2584 (2.3); 4.2196 (2.1); 4.1333 (3.9); 4.1280 (1.4); 4.1242 (2.4); 4.1213 (3.9); 4.1157 (1.4); 4.1098 (3.3); 3.9158 (0.4); 3.9050 (0.7); 3.8946 (1.0); 3.8841 (1.2); 3.8738 (1.1); 3.8633 (0.8); 3.8527 (0.4); 3.6678 (2.8); 2.7717 (1.6); 2.7616 (1.7); 2.7328 (2.1); 2.7227 (2.1); 2.5438 (0.4); 2.5262 (0.5); 2.5212 (0.4); 2.5191 (0.4); 2.5015 (1.1); 2.4828 (1.0); 2.4766 (3.1); 2.4593 (1.0); 2.4547 (2.3); 2.4377 (2.0); 2.4196 (1.2); 2.4158 (2.0); 2.4053 (1.2); 2.3951 (1.6); 2.3808 (1.5); 2.3769 (0.7); 2.3628 (0.5); 2.3523 (0.8); 2.3383 (0.9); 2.3013 (0.7); 2.2848 (16.0); 2.2690 (1.0); 2.2640 (0.8); 2.2574 (0.7); 2.2494 (0.9); 2.2444 (0.6); 2.2395 (0.5); 2.2312 (0.6); 2.2247 (0.6); 2.2066 (0.4); 2.1320 (0.4); 2.0040 (0.4); 1.8792 (0.5); 1.8678 (0.6); 1.8654 (0.7); 1.8546 (0.8); 1.8467 (0.6); 1.8440 (0.7); 1.8412 (0.7); 1.8354 (0.6); 1.8330 (0.7); 1.8297 (0.6); 1.8217 (0.7); 1.8112 (0.5); 1.8084 (0.5); 1.7969 (0.4); 1.5619 (6.3); 1.2553 (0.5) I.1-038: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.3803 (0.5); 7.3639 (1.0); 7.3598 (1.1); 7.3537 (0.6); 7.3440 (0.7); 7.3380 (1.1); 7.3336 (1.0); 7.3176 (0.6); 7.3136 (0.6); 7.2100 (0.6); 7.2061 (0.7); 7.1973 (0.6); 7.1935 (0.8); 7.1902 (1.2); 7.1864 (1.3); 7.1775 (1.2); 7.1739 (1.3); 7.1698 (0.8); 7.1659 (0.8); 7.1571 (0.7); 7.1534 (0.8); 7.0994 (1.2); 7.0832 (1.6); 7.0639 (0.8); 4.7475 (1.3); 4.7079 (1.5); 4.6399 (1.2); 4.6290 (1.3); 4.6253 (1.5); 4.6144 (1.4); 4.6133 (1.4); 4.6096 (1.3); 4.5988 (1.2); 4.2576 (2.2); 4.2179 (1.9); 3.8070 (0.8); 3.7968 (1.2); 3.7868 (1.4); 3.7766 (1.1); 3.7664 (0.8); 3.4183 (25.7); 3.1677 (1.0); 2.7849 (1.0); 2.7745 (1.1); 2.7689 (1.1); 2.7587 (1.1); 2.7456 (1.4); 2.7352 (1.4); 2.7298 (1.4); 2.7197 (1.3); 2.6699 (0.6); 2.5233 (1.1); 2.5186 (1.7); 2.5100 (30.5); 2.5054 (66.0); 2.5007 (92.6); 2.4961 (65.3); 2.4915 (30.8); 2.4810 (2.2); 2.4741 (1.6); 2.4629 (1.4); 2.4530 (1.6); 2.4417 (1.4); 2.4248 (0.6); 2.4107 (0.8); 2.4001 (0.8); 2.3929 (0.6); 2.3841 (0.8); 2.3758 (0.6); 2.3275 (0.6); 2.3028 (0.6); 2.2999 (0.6); 2.2890 (0.7); 2.2866 (0.7); 2.2783 (1.0); 2.2751 (1.0); 2.2645 (1.1); 2.2620 (1.2); 2.2367 (0.7); 2.2337 (0.7); 2.2269 (1.7); 2.2135 (0.8); 2.2107 (0.9); 2.1999 (0.9); 2.1942 (0.7); 2.1859 (0.5); 2.1823 (1.0); 2.1754 (0.6); 2.1625 (0.7); 2.1562 (0.6); 1.7676 (0.5); 1.7565 (0.8); 1.7484 (0.8); 1.7373 (1.0); 1.7298 (0.6); 1.7254 (1.3); 1.7227 (1.5); 1.7123 (0.8); 1.7056 (2.1); 1.6912 (1.8); 1.6886 (1.4); 1.6741 (1.2); 1.0775 (10.2); 1.0693 (10.3); 1.0616 (10.3); 1.0533 (10.1); 0.8384 (8.8); 0.8341 (16.0); 0.8316 (10.6); 0.8214 (8.8); 0.8171 (15.3); 0.8146 (10.4); 0.0079 (0.6); 0.0021 (0.8); -0.0002 (21.6); -0.0027 (1.2); -0.0085 (0.7) I.1-039: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.9822 (0.9); 8.9751 (2.5); 8.9723 (2.4); 8.5699 (1.0); 8.5500 (1.0); 7.3976 (2.7); 7.3588 (0.8); 7.3362 (0.8); 7.1830 (0.8); 7.1703 (0.9); 7.0676 (0.7); 7.0480 (1.1); 7.0319 (0.6); 4.7177 (1.0); 4.6788 (1.3); 4.6586 (0.6); 4.6454 (0.6); 4.6384 (0.6); 4.1850 (1.2); 4.1450 (1.0); 3.7248 (0.7); 3.7144 (0.8); 3.7040 (0.7); 3.6433 (16.0); 3.6323 (5.2); 3.4005 (43.8); 3.1683 (1.9); 3.1533 (0.7); 3.1285 (0.9); 3.1152 (0.9); 3.0044 (0.9); 2.9808 (0.9); 2.9666 (0.7); 2.9433 (0.6); 2.6701 (0.7); 2.6654 (0.5); 2.5634 (0.8); 2.5523 (0.8); 2.5278 (1.3); 2.5236 (1.7); 2.5187 (2.7); 2.5102 (38.1); 2.5056 (83.0); 2.5010 (116.5); 2.4964 (81.0); 2.4918 (36.4); 2.3371 (0.6); 2.3326 (0.7); 2.3278 (0.8); 2.3231 (0.6); 2.3166 (0.8); 2.2955 (1.0); 2.2733 (0.7); 2.2567 (0.8); 2.2417 (1.4); 2.2323 (1.0); 2.2193 (1.7); 2.2058 (1.0); 2.2009 (0.7); 2.1845 (0.8); 2.0105 (0.5); 1.9785 (0.5); -0.0002 (1.4) I.1-040: 1 H-NMR (400.1 MHz, CDCl 3 ): δ= 7.5939 (0.3); 7.5408 (0.4); 7.5191 (1.0); 7.3295 (0.7); 7.3245 (5.0); 7.3186 (2.4); 7.3138 (0.4); 7.3083 (3.6); 7.3021 (16.0); 7.2973 (3.2); 7.2914 (0.7); 7.2869 (3.2); 7.2816 (16.7); 7.2759 (3.9); 7.2727 (1.0); 7.2719 (1.0); 7.2711 (1.0); 7.2703 (0.9); 7.2694 (1.0); 7.2686 (1.1); 7.2654 (4.2); 7.2645 (4.0); 7.2604 (153.4); 7.2553 (3.7); 7.2545 (3.1); 7.2537 (2.3); 7.2528 (1.9); 7.2520 (1.7); 7.2512 (1.5); 7.2504 (1.3); 7.2495 (1.1); 7.2487 (1.0); 7.2479 (0.8); 7.2471 (0.8); 7.2463 (0.7); 7.2454 (0.6); 7.2446 (0.6); 7.2438 (0.5); 7.2430 (0.5); 7.2422 (0.4); 7.2414 (0.4); 7.2405 (0.4); 7.2397 (0.4); 7.2389 (0.3); 7.2381 (0.3); 7.1274 (0.5); 7.1146 (1.2); 7.1098 (0.6); 7.1025 (2.2); 7.0917 (1.1); 7.0845 (1.9); 7.0777 (2.3); 7.0738 (1.2); 7.0673 (1.2); 7.0588 (7.1); 7.0524 (3.9); 7.0471 (6.2); 7.0399 (2.4); 7.0347 (2.8); 7.0275 (0.5); 6.9964 (0.8); 4.8845 (2.5); 4.8805 (2.5); 4.8457 (2.8); 4.8417 (2.7); 4.2610 (0.4); 4.2428 (3.8); 4.2360 (6.6); 4.2190 (13.7); 4.2022 (8.9); 3.8803 (0.6); 3.8696 (1.1); 3.8591 (1.7); 3.8489 (1.9); 3.8383 (1.6); 3.8279 (1.2); 3.8174 (0.6); 3.6680 (4.6); 3.1049 (6.9); 3.0880 (14.1); 3.0710 (6.5); 2.7004 (2.8); 2.6903 (2.8); 2.6615 (3.6); 2.6513 (3.4); 2.5420 (0.6); 2.5239 (0.7); 2.5193 (0.7); 2.4997 (1.8); 2.4809 (1.5); 2.4765 (1.4); 2.4576 (1.5); 2.4367 (0.6); 2.4311 (1.8); 2.4241 (0.4); 2.4165 (2.2); 2.4065 (2.7); 2.4019 (4.1); 2.3922 (2.6); 2.3882 (1.1); 2.3802 (3.8); 2.3739 (1.0); 2.3631 (4.0); 2.3495 (1.4); 2.3412 (2.9); 2.3002 (1.1); 2.2809 (1.3); 2.2760 (0.8); 2.2678 (1.2); 2.2625 (1.0); 2.2564 (1.0); 2.2482 (1.4); 2.2432 (1.1); 2.2381 (0.7); 2.2298 (1.0); 2.2237 (1.1); 2.2052 (0.6); 2.0945 (2.9); 2.0048 (0.9); 1.8549 (0.9); 1.8435 (1.0); 1.8410 (1.2); 1.8301 (1.4); 1.8222 (1.0); 1.8197 (1.2); 1.8170 (1.1); 1.8109 (1.0); 1.8083 (1.1); 1.8054 (1.0); 1.7971 (1.2); 1.7870 (0.8); 1.7842 (0.7); 1.7725 (0.7); 1.5518 (8.7); 1.2555 (1.0); 0.0083 (0.8); 0.0059 (0.4); 0.0051 (0.4); 0.0043 (0.6); 0.0034 (0.8); 0.0025 (1.4) I.1-041: 1 H-NMR (400.1 MHz, d6-DMSO): δ= 16.4145 (0.6); 16.2990 (0.6); 16.2499 (0.6); 13.9263 (0.6); 12.3927 (0.6); 12.3615 (0.9); 12.3469 (1.7); 12.3246 (9.3); 12.2694 (0.6); 8.0558 (0.6); 7.6338 (1.2); 7.4203 (6.3); 7.3990 (13.3); 7.3933 (7.1); 7.3779 (8.1); 7.3720 (13.5); 7.3508 (7.1); 7.3073 (5.7); 7.3022 (6.1); 7.2877 (6.1); 7.2824 (6.9); 7.2732 (6.5); 7.2589 (5.6); 7.2535 (5.9); 7.1008 (6.3); 7.0960 (6.2); 7.0915 (6.5); 7.0862 (6.5); 7.0800 (5.9); 4.6385 (0.6); 4.6242 (12.7); 4.5855 (14.4); 4.2602 (0.6); 4.2387 (0.8); 4.2237 (0.6); 4.1570 (16.0); 4.1184 (13.8); 3.7772 (8.5); 3.7675 (2.8); 3.7564 (4.8); 3.7457 (7.3); 3.7356 (7.4); 3.7256 (6.9); 3.7149 (5.5); 3.7041 (2.4); 3.6002 (0.6); 3.5093 (1.4); 3.4927 (1.0); 3.4465 (2.0); 3.4404 (2.0); 3.4278 (1.9); 3.4105 (2.2); 3.3184 (45.5); 3.1684 (1.6); 3.1444 (0.9); 3.1291 (0.7); 3.1143 (0.7); 3.0862 (7.0); 3.0544 (0.6); 3.0413 (0.6); 2.6916 (11.1); 2.6815 (11.6); 2.6745 (2.3); 2.6695 (2.5); 2.6647 (1.9); 2.6518 (14.1); 2.6417 (13.3); 2.6128 (0.6); 2.5984 (0.7); 2.5785 (0.7); 2.5577 (0.6); 2.5097 (120.2); 2.5051 (262.8); 2.5006 (368.2); 2.4960 (264.0); 2.4915 (123.8); 2.4397 (3.2); 2.4224 (4.0); 2.4159 (3.6); 2.3985 (9.0); 2.3805 (7.2); 2.3741 (6.4); 2.3577 (6.2); 2.3456 (14.0); 2.3323 (2.4); 2.3233 (15.1); 2.3055 (15.7); 2.2906 (7.3); 2.2833 (13.9); 2.2663 (9.6); 2.2499 (2.0); 2.2385 (5.7); 2.2258 (6.2); 2.2160 (4.3); 2.1980 (5.4); 2.1922 (2.6); 2.1861 (4.9); 2.1808 (4.0); 2.1731 (3.6); 2.1689 (5.8); 2.1621 (3.7); 2.1566 (2.4); 2.1491 (4.0); 2.1440 (3.9); 2.1246 (2.2); 2.0715 (1.5); 1.7418 (3.1); 1.7305 (5.2); 1.7191 (6.1); 1.7084 (5.0); 1.7004 (5.9); 1.6947 (3.8); 1.6878 (5.5); 1.6764 (4.0); 1.6623 (2.6); 1.3037 (0.6); 1.2668 (0.7); 1.2345 (3.6); 1.1852 (0.7); 1.1780 (0.7); 1.1595 (0.8); 1.1415 (0.6); 1.1247 (0.7); 0.8675 (0.9); 0.8546 (0.8); 0.8281 (0.7); 0.8099 (0.7); 0.0081 (3.1) I.1-042: 1 H-NMR (400.1 MHz, CDCl 3 ): δ= 8.0105 (0.4); 7.9829 (0.5); 7.9140 (0.4); 7.7961 (0.4); 7.6100 (0.4); 7.5591 (0.4); 7.5306 (0.5); 7.5191 (0.9); 7.4864 (0.6); 7.4556 (0.4); 7.4145 (0.9); 7.3816 (8.9); 7.3636 (12.6); 7.3494 (1.2); 7.3163 (6.0); 7.2981 (12.8); 7.2795 (7.3); 7.2602 (120.3); 7.2396 (1.4); 7.2365 (1.1); 7.2227 (1.9); 7.2103 (0.8); 7.2065 (0.7); 7.2036 (1.1); 7.2001 (0.6); 7.1777 (2.6); 7.1529 (0.4); 7.1455 (1.4); 7.1288 (1.3); 7.1087 (4.8); 7.0835 (3.8); 7.0627 (2.6); 7.0478 (3.3); 7.0266 (1.6); 6.9965 (0.6); 6.9481 (3.0); 6.6665 (0.3); 4.7604 (5.3); 4.7221 (5.7); 4.2513 (7.6); 4.2344 (14.9); 4.2176 (6.9); 4.1329 (0.4); 4.0809 (6.3); 4.0427 (5.4); 3.8732 (1.1); 3.8612 (2.0); 3.8514 (2.7); 3.8409 (3.7); 3.8307 (2.6); 3.8205 (1.8); 3.8093 (0.6); 3.4900 (0.4); 3.1239 (8.7); 3.1071 (16.0); 3.0905 (6.8); 3.0246 (0.4); 2.5803 (3.6); 2.5691 (3.4); 2.5412 (4.8); 2.5302 (5.3); 2.5105 (2.9); 2.4917 (2.7); 2.4684 (2.3); 2.4458 (2.2); 2.4314 (2.5); 2.4214 (3.1); 2.4069 (3.3); 2.3882 (0.8); 2.3785 (1.3); 2.3640 (1.4); 2.3304 (4.5); 2.3094 (4.4); 2.2913 (3.6); 2.2705 (4.4); 2.2627 (1.5); 2.2520 (1.6); 2.2432 (2.1); 2.2192 (1.5); 2.1988 (0.6); 2.0040 (0.5); 1.8394 (1.2); 1.8275 (1.9); 1.8147 (2.0); 1.8036 (2.1); 1.7917 (2.0); 1.7826 (1.7); 1.7707 (1.2); 1.7566 (0.7); 1.6507 (0.6); 1.5618 (20.4); 1.4781 (0.6); 1.4433 (0.4); 1.2579 (0.4); 0.0886 (0.3); 0.0000 (19.6) I.1-044: 1 H-NMR (400.1 MHz, d6-DMSO): δ= 18.4071 (0.6); 14.1020 (0.4); 12.3265 (5.4); 10.2103 (0.4); 8.6838 (0.4); 8.6715 (0.5); 7.6579 (2.6); 7.4492 (0.7); 7.4449 (0.7); 7.4205 (5.8); 7.3994 (12.0); 7.3937 (6.4); 7.3782 (7.0); 7.3724 (11.9); 7.3512 (6.6); 7.3071 (5.4); 7.3023 (5.7); 7.2879 (5.6); 7.2789 (6.6); 7.2735 (5.7); 7.2586 (5.4); 7.2534 (5.3); 7.1306 (0.5); 7.1017 (6.0); 7.0913 (6.1); 7.0864 (6.5); 7.0814 (5.6); 5.0716 (0.5); 4.6239 (12.5); 4.5851 (14.8); 4.2367 (0.6); 4.2230 (0.8); 4.2075 (0.5); 4.1572 (16.0); 4.1179 (13.8); 4.0888 (0.5); 4.0408 (0.4); 3.9751 (0.5); 3.9466 (0.7); 3.9267 (0.5); 3.8852 (0.4); 3.8613 (0.5); 3.8302 (0.5); 3.8102 (0.5); 3.7760 (14.1); 3.7667 (3.1); 3.7567 (5.0); 3.7460 (7.3); 3.7355 (7.6); 3.7251 (6.9); 3.7151 (5.3); 3.7043 (2.7); 3.6830 (0.7); 3.6480 (0.7); 3.6187 (0.8); 3.5891 (0.9); 3.5436 (1.1); 3.5103 (2.8); 3.4910 (2.7); 3.4693 (2.4); 3.3132 (248.5); 3.1696 (3.7); 3.1241 (0.9); 3.0929 (11.2); 3.0592 (0.7); 3.0500 (0.6); 3.0368 (0.6); 3.0291 (0.6); 3.0023 (0.6); 2.9993 (0.6); 2.9374 (0.5); 2.9081 (0.6); 2.8777 (0.6); 2.8287 (0.5); 2.8087 (0.4); 2.6914 (10.5); 2.6812 (11.0); 2.6742 (4.4); 2.6694 (5.8); 2.6650 (4.5); 2.6516 (13.1); 2.6415 (12.4); 2.6234 (0.7); 2.6006 (1.2); 2.5679 (0.6); 2.5546 (3.7); 2.5498 (5.6); 2.5456 (4.7); 2.5227 (10.4); 2.5092 (317.6); 2.5048 (667.4); 2.5004 (914.8); 2.4960 (655.6); 2.4917 (310.5); 2.4571 (3.3); 2.4470 (1.0); 2.4399 (1.9); 2.4225 (3.5); 2.4149 (3.2); 2.3983 (8.4); 2.3810 (6.5); 2.3751 (6.0); 2.3578 (5.9); 2.3454 (12.8); 2.3231 (16.2); 2.3052 (14.9); 2.2904 (6.5); 2.2829 (12.6); 2.2659 (8.8); 2.2494 (1.8); 2.2386 (5.1); 2.2259 (5.8); 2.2166 (4.1); 2.1984 (5.0); 2.1862 (4.5); 2.1801 (3.7); 2.1681 (5.7); 2.1625 (3.6); 2.1568 (2.4); 2.1487 (3.5); 2.1423 (3.8); 2.1249 (2.0); 2.0714 (3.1); 1.7589 (0.5); 1.7421 (2.6); 1.7307 (5.0); 1.7186 (5.9); 1.7075 (5.0); 1.6999 (5.6); 1.6944 (3.7); 1.6874 (5.3); 1.6754 (3.7); 1.6630 (2.4); 1.5083 (0.5); 1.3602 (0.6); 1.3432 (0.5); 1.2361 (6.2); 1.1965 (0.8); 1.1755 (0.7); 1.1588 (0.7); 1.1415 (0.7); 1.0849 (0.5); 0.9120 (0.7); 0.8950 (0.5); 0.8681 (0.7); 0.8532 (1.1); 0.8360 (0.9); 0.8148 (0.6); 0.1469 (1.0); 0.0498 (1.2); 0.0081 (6.4); 0.0006 (191.7); 0.0000 (199.1) I.1-046: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 12.7567 (0.8); 8.3619 (3.9); 8.3516 (3.1); 8.3412 (3.9); 8.3310 (2.9); 7.3727 (1.3); 7.3473 (3.1); 7.3267 (3.3); 7.3062 (1.8); 7.2825 (3.5); 7.2643 (9.7); 7.2466 (14.1); 7.2294 (8.3); 7.2177 (14.3); 7.2114 (12.4); 7.2047 (9.5); 7.2001 (9.4); 7.1862 (8.9); 7.1690 (4.5); 7.0540 (2.1); 7.0381 (4.4); 7.0187 (3.5); 7.0020 (1.2); 4.6968 (3.4); 4.6775 (2.5); 4.6566 (3.8); 4.6384 (2.9); 4.4900 (1.5); 4.4786 (1.5); 4.4653 (2.2); 4.4546 (2.5); 4.4442 (2.5); 4.4331 (2.2); 4.4229 (1.5); 4.3971 (1.0); 4.1805 (4.0); 4.1404 (3.6); 4.1247 (2.8); 4.0835 (2.5); 3.9638 (2.9); 3.6687 (2.2); 3.6574 (2.8); 3.6472 (2.9); 3.6368 (2.6); 3.6242 (2.3); 3.6140 (1.9); 3.6026 (1.6); 3.4414 (69.2); 3.1663 (16.0); 3.0935 (2.3); 3.0824 (2.9); 3.0744 (1.9); 3.0592 (3.0); 3.0482 (3.4); 3.0402 (2.2); 2.8384 (3.1); 2.8128 (3.2); 2.8038 (2.9); 2.7783 (2.5); 2.6990 (1.6); 2.6790 (2.2); 2.6745 (4.8); 2.6699 (6.7); 2.6653 (4.8); 2.5568 (1.6); 2.5522 (1.6); 2.5471 (1.3); 2.5401 (3.9); 2.5363 (4.6); 2.5233 (18.8); 2.5186 (27.7); 2.5100 (388.7); 2.5054 (843.8); 2.5008 (1175.8); 2.4962 (827.4); 2.4916 (375.5); 2.4669 (3.8); 2.4568 (5.0); 2.4521 (3.3); 2.4468 (1.7); 2.3812 (1.3); 2.3369 (2.9); 2.3322 (5.5); 2.3276 (7.5); 2.3229 (5.4); 2.3181 (2.8); 2.2913 (2.0); 2.2695 (3.3); 2.2476 (4.0); 2.2270 (3.8); 2.1974 (2.3); 2.1880 (4.2); 2.1728 (5.5); 2.1654 (5.0); 2.1529 (4.8); 2.1377 (3.5); 2.1316 (3.5); 2.1158 (3.3); 2.0732 (1.8); 1.9407 (1.1); 1.9087 (1.3); 1.8851 (1.6); 1.8636 (1.8); 1.8513 (1.3); 1.8393 (1.6); 1.8316 (1.9); 1.8073 (1.7); 1.7879 (0.8); 1.6787 (1.0); 1.6661 (1.3); 1.6558 (1.3); 1.6449 (1.3); 1.4707 (1.2); 1.4600 (1.8); 1.4491 (1.6); 1.4377 (1.6); 1.4273 (1.6); 1.0281 (2.0); 0.1460 (1.2); 0.0080 (9.4); -0.0002 (340.8); -0.0086 (10.2); -0.1495 (1.0) I.1-047: 1 H-NMR (400.1 MHz, CDCl3): δ= 7.3933 (0.3); 7.3855 (3.3); 7.3800 (1.1); 7.3688 (1.1); 7.3633 (3.7); 7.3555 (0.4); 7.2679 (0.3); 7.2670 (0.4); 7.2662 (0.6); 7.2653 (0.7); 7.2609 (28.8); 7.2514 (0.3); 7.0961 (0.6); 7.0857 (0.4); 7.0783 (0.6); 7.0712 (0.6); 7.0672 (0.5); 7.0599 (0.5); 7.0523 (2.3); 7.0459 (1.2); 7.0418 (2.1); 7.0339 (1.0); 7.0282 (0.8); 6.8670 (0.4); 6.8593 (3.4); 6.8538 (1.1); 6.8426 (1.0); 6.8372 (3.2); 6.8294 (0.4); 4.8816 (0.7); 4.8778 (0.8); 4.8429 (0.8); 4.8390 (0.8); 4.2401 (1.1); 4.1991 (2.5); 4.1820 (4.0); 4.1651 (2.0); 3.8721 (0.4); 3.8614 (1.0); 3.8513 (0.6); 3.8408 (0.5); 3.8303 (0.4); 3.7955 (16.0); 3.6680 (1.6); 3.0034 (2.0); 2.9865 (4.2); 2.9695 (1.9); 2.7015 (0.9); 2.6915 (0.9); 2.6627 (1.1); 2.6527 (1.0); 2.5003 (0.6); 2.4818 (0.5); 2.4773 (0.4); 2.4583 (0.5); 2.4281 (0.5); 2.4140 (0.7); 2.4036 (0.8); 2.3964 (1.3); 2.3893 (0.8); 2.3853 (0.4); 2.3744 (1.2); 2.3605 (0.5); 2.3576 (1.0); 2.3467 (0.4); 2.3356 (0.9); 2.3009 (0.3); 2.2817 (0.4); 2.2685 (0.4); 2.2633 (0.3); 2.2572 (0.3); 2.2491 (0.4); 2.2440 (0.3); 2.2245 (0.3); 2.0923 (1.1); 1.8509 (0.4); 1.8486 (0.4); 1.8377 (0.5); 1.8295 (0.4); 1.8272 (0.4); 1.8244 (0.3); 1.8184 (0.4); 1.8160 (0.4); 1.8047 (0.4); 1.5634 (1.2) I.1-048: 1 H-NMR (400.1 MHz, CDCl 3 ): δ= 7.5187 (0.4); 7.3014 (4.4); 7.2812 (5.5); 7.2755 (1.2); 7.2616 (58.1); 7.2599 (62.6); 7.2091 (0.8); 7.1221 (4.6); 7.1012 (3.6); 7.0874 (0.7); 7.0797 (1.1); 7.0721 (1.1); 7.0618 (0.7); 7.0518 (3.7); 7.0417 (3.7); 7.0332 (1.3); 7.0290 (1.3); 6.9961 (0.4); 4.8778 (1.6); 4.8392 (1.7); 4.2391 (2.4); 4.2249 (3.1); 4.2078 (6.4); 4.2007 (2.3); 4.1912 (3.2); 3.8783 (0.3); 3.8682 (0.7); 3.8574 (1.0); 3.8470 (1.2); 3.8366 (1.0); 3.8264 (0.7); 3.8157 (0.3); 3.0740 (3.2); 3.0570 (6.3); 3.0402 (3.0); 2.6982 (1.4); 2.6883 (1.4); 2.6594 (1.8); 2.6494 (1.7); 2.5387 (0.4); 2.5206 (0.5); 2.5144 (0.5); 2.4960 (1.2); 2.4776 (1.1); 2.4718 (0.9); 2.4537 (1.0); 2.4246 (1.2); 2.4106 (1.0); 2.4005 (1.2); 2.3869 (3.0); 2.3661 (2.0); 2.3580 (0.8); 2.3483 (1.6); 2.3439 (0.8); 2.3216 (16.0); 2.2966 (0.5); 2.2778 (0.7); 2.2710 (0.4); 2.2637 (0.6); 2.2589 (0.5); 2.2534 (0.6); 2.2451 (0.9); 2.2393 (0.5); 2.2346 (0.4); 2.2253 (0.5); 2.2207 (0.6); 2.2015 (0.3); 2.0046 (0.5); 1.8555 (0.4); 1.8434 (0.7); 1.8311 (0.8); 1.8218 (0.7); 1.8103 (0.7); 1.8081 (0.7); 1.7985 (0.7); 1.7868 (0.5); 1.5476 (23.8); 0.0018 (5.3) I.1-049: 1 H-NMR (400.0 MHz, CDCl3): δ= 7.3483 (0.5); 7.3441 (0.6); 7.3275 (0.9); 7.3107 (0.6); 7.3065 (0.6); 7.2649 (8.0); 7.1927 (1.0); 7.1766 (0.6); 7.1726 (0.5); 7.0784 (0.9); 7.0759 (0.9); 7.0586 (1.3); 7.0562 (1.4); 7.0391 (0.6); 7.0365 (0.6); 5.3007 (1.1); 4.8692 (0.9); 4.8324 (1.0); 4.2589 (1.3); 4.2200 (1.2); 3.9037 (0.6); 3.8933 (0.8); 3.8830 (0.6); 3.6676 (16.0); 2.7314 (0.9); 2.7210 (1.0); 2.6924 (1.2); 2.6821 (1.2); 2.5138 (0.7); 2.4948 (0.6); 2.4901 (0.5); 2.4717 (0.6); 2.4429 (1.9); 2.4281 (0.8); 2.4214 (1.4); 2.4182 (1.1); 2.4040 (1.9); 2.3825 (1.0); 2.3751 (0.5); 2.3613 (0.5); 2.3035 (0.5); 2.2714 (0.6); 1.8554 (0.5); 1.2611 (0.5); 1.2544 (1.0); - 0.0002 (4.9) I.1-050: 1 H-NMR (400.1 MHz, d6-DMSO): δ= 8.1400 (0.8); 8.1190 (0.8); 8.0535 (1.4); 8.0319 (1.4); 7.3771 (0.6); 7.3733 (0.6); 7.3525 (1.3); 7.3310 (1.4); 7.3106 (0.6); 7.2016 (0.7); 7.1828 (1.3); 7.1700 (1.4); 7.1502 (0.7); 7.0904 (1.0); 7.0715 (1.6); 7.0562 (0.8); 4.7376 (1.8); 4.6973 (2.0); 4.3465 (1.3); 4.3350 (1.4); 4.3245 (1.3); 4.3131 (1.4); 4.2479 (2.1); 4.2079 (1.8); 4.1679 (0.8); 4.1530 (0.8); 4.1472 (0.8); 4.1323 (0.8); 3.8020 (0.4); 3.7918 (0.8); 3.7808 (1.2); 3.7701 (1.5); 3.7599 (1.2); 3.7496 (0.9); 3.7390 (0.5); 3.4708 (0.3); 3.3853 (16.0); 2.6741 (0.6); 2.6692 (0.8); 2.6647 (0.6); 2.6570 (1.1); 2.6460 (1.0); 2.6312 (0.6); 2.6224 (1.5); 2.6114 (1.2); 2.5966 (0.8); 2.5856 (0.8); 2.5397 (0.5); 2.5227 (1.2); 2.5094 (40.5); 2.5048 (89.4); 2.5002 (126.9); 2.4956 (92.5); 2.4910 (44.2); 2.4498 (0.4); 2.4187 (0.4); 2.3957 (0.8); 2.3768 (1.2); 2.3545 (1.4); 2.3357 (2.2); 2.3274 (1.2); 2.3227 (0.9); 2.3138 (1.7); 2.3016 (1.2); 2.2936 (0.9); 2.2880 (1.1); 2.2792 (1.6); 2.2762 (1.4); 2.2636 (1.4); 2.2511 (1.3); 2.2332 (0.6); 2.2213 (0.7); 2.2094 (0.7); 2.1245 (0.5); 2.1047 (1.0); 2.0928 (0.8); 2.0808 (1.0); 2.0716 (1.7); 2.0616 (0.5); 2.0490 (1.0); 2.0296 (0.4); 1.8788 (0.4); 1.8617 (0.7); 1.8494 (0.8); 1.8438 (1.1); 1.8318 (1.3); 1.8205 (0.9); 1.8113 (1.0); 1.8023 (0.9); 1.7986 (0.9); 1.7889 (0.9); 1.7774 (0.8); 1.7721 (0.6); 1.7661 (0.6); 1.7481 (0.5); 1.3824 (0.4); 1.3717 (0.3); 1.3636 (0.3); 1.2960 (0.4); 1.2781 (0.7); 1.2615 (1.0); 1.2441 (1.0); 1.2260 (0.8); 1.2077 (0.5); 1.1896 (0.4); 1.1729 (0.5); 1.1669 (0.4); 1.1535 (0.8); 1.1347 (1.2); 1.1170 (0.9); 1.1004 (0.7); 1.0826 (0.4); 0.8484 (13.8); 0.8314 (15.4); 0.8156 (4.2); 0.0082 (0.4) I.1-051: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 7.1339 (4.0); 7.1115 (12.4); 7.0979 (8.4); 7.0901 (4.2); 7.0778 (1.9); 6.9528 (3.6); 6.9418 (3.6); 6.9356 (1.7); 6.9298 (2.7); 6.9188 (2.6); 4.6503 (2.0); 4.6119 (2.2); 4.3157 (1.3); 4.3053 (3.3); 4.2946 (3.4); 4.2844 (1.5); 4.1260 (3.2); 4.1147 (4.8); 4.1036 (2.4); 4.0517 (2.2); 4.0133 (1.9); 3.7274 (0.7); 3.7168 (1.1); 3.7059 (1.2); 3.6958 (1.0); 3.6853 (0.7); 3.3469 (2.4); 3.3223 (495.0); 3.2912 (0.8); 3.1675 (0.9); 2.7817 (1.4); 2.7713 (1.4); 2.7416 (1.8); 2.7315 (1.6); 2.6704 (1.0); 2.5403 (0.7); 2.5102 (64.0); 2.5058 (132.9); 2.5013 (180.1); 2.4968 (126.4); 2.4925 (58.1); 2.4797 (2.7); 2.4579 (2.0); 2.4400 (1.6); 2.4180 (1.8); 2.3913 (1.3); 2.3728 (1.0); 2.3496 (0.8); 2.3280 (1.1); 2.2634 (16.0); 2.2501 (1.4); 2.2363 (1.3); 2.2080 (0.7); 2.1952 (0.8); 2.1376 (0.7); 2.1251 (0.6); 2.1125 (0.6); 2.1062 (0.9); 2.0874 (0.6); 2.0730 (0.8); 1.7173 (0.6); 1.7051 (0.8); 1.6944 (0.7); 1.6846 (0.7); 1.6733 (0.7); 1.6603 (0.6); -0.0002 (5.3) I.1-052: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.2642 (2.9); 7.2466 (4.4); 7.2114 (4.8); 3.3179 (1950.0); 3.2683 (4.4); 3.1666 (16.0); 2.6747 (5.7); 2.6699 (8.5); 2.6652 (5.5); 2.5402 (3.9); 2.5234 (18.8); 2.5186 (28.8); 2.5100 (477.4); 2.5054 (1050.3); 2.5008 (1468.1); 2.4962 (1027.3); 2.4916 (461.4); 2.4560 (4.0); 2.3323 (6.1); 2.3276 (8.3); 2.3228 (6.3); 2.1528 (2.0); 2.0729 (2.6); -0.0002 (69.2) I.1-053: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.8999 (0.8); 7.8930 (6.8); 7.8879 (1.9); 7.8758 (2.0); 7.8706 (7.1); 7.8636 (0.6); 7.1256 (1.8); 7.1052 (7.8); 7.0929 (8.4); 7.0720 (1.8); 7.0253 (0.8); 7.0183 (6.7); 7.0131 (1.8); 7.0011 (1.8); 6.9959 (6.3); 6.9888 (0.5); 4.6458 (1.9); 4.6073 (2.2); 4.3537 (1.1); 4.3430 (2.7); 4.3337 (2.9); 4.3241 (1.6); 4.2367 (3.0); 4.2256 (3.7); 4.2150 (1.8); 4.0487 (2.2); 4.0106 (2.0); 3.7270 (0.7); 3.7165 (1.0); 3.7061 (1.2); 3.6959 (1.0); 3.6856 (0.8); 3.3211 (219.8); 3.2724 (0.8); 3.1693 (2.0); 2.7811 (1.4); 2.7710 (1.5); 2.7413 (1.8); 2.7311 (1.7); 2.6746 (0.7); 2.6699 (0.9); 2.6653 (0.7); 2.5400 (0.5); 2.5233 (2.6); 2.5186 (3.7); 2.5100 (54.7); 2.5054 (118.2); 2.5008 (164.3); 2.4962 (113.4); 2.4916 (50.6); 2.4808 (2.5); 2.4591 (2.1); 2.4411 (1.7); 2.4267 (0.6); 2.4193 (1.7); 2.4087 (0.6); 2.4025 (0.6); 2.3854 (1.1); 2.3670 (0.9); 2.3612 (0.8); 2.3437 (0.8); 2.3322 (0.7); 2.3275 (1.0); 2.3230 (0.7); 2.2596 (16.0); 2.2448 (1.4); 2.2310 (1.3); 2.2143 (0.5); 2.2028 (0.8); 2.1899 (0.8); 2.1344 (0.7); 2.1221 (0.6); 2.1163 (0.5); 2.1094 (0.6); 2.1027 (0.8); 2.0840 (0.5); 2.0780 (0.6); 2.0707 (0.7); 1.7152 (0.6); 1.7036 (0.8); 1.6928 (0.7); 1.6832 (0.7); 1.6718 (0.8); -0.0002 (0.8) I.1-055: 1 H-NMR (400.1 MHz, CDCl 3 ): δ= 7.5192 (0.4); 7.3112 (0.8); 7.2604 (80.4); 7.2118 (0.7); 7.1461 (0.5); 7.1254 (1.1); 7.1215 (0.9); 7.1152 (0.6); 7.1094 (0.6); 7.1050 (0.9); 7.1004 (1.4); 7.0894 (0.8); 7.0803 (1.1); 7.0684 (0.6); 7.0636 (0.6); 6.9966 (1.1); 6.9877 (0.6); 6.9766 (0.6); 6.9738 (0.6); 4.7296 (0.4); 4.6329 (1.3); 4.5946 (1.6); 4.2674 (1.6); 4.2290 (1.3); 4.1073 (0.4); 4.0753 (0.6); 4.0667 (0.8); 4.0555 (1.1); 4.0451 (0.7); 4.0359 (0.6); 3.6587 (3.7); 3.1766 (15.7); 3.1143 (16.0); 2.9657 (1.0); 2.9540 (1.1); 2.9497 (3.7); 2.9235 (1.3); 2.9122 (1.2); 2.8491 (1.8); 2.8357 (1.7); 2.6744 (1.3); 2.6544 (1.2); 2.6324 (1.0); 2.6124 (1.0); 2.5892 (0.6); 2.5776 (0.4); 2.5707 (0.4); 2.5473 (0.9); 2.5276 (1.0); 2.5048 (0.8); 2.4772 (0.6); 2.4635 (0.7); 2.4530 (0.9); 2.4396 (0.9); 2.4344 (0.5); 2.4202 (0.4); 2.4101 (0.5); 2.3973 (0.5); 2.3901 (0.5); 2.3721 (0.5); 2.3536 (0.7); 2.3408 (0.4); 2.3344 (0.4); 2.3300 (0.7); 2.3214 (0.7); 2.3167 (0.4); 2.3011 (0.4); 2.2967 (0.6); 2.0045 (0.4); 1.8379 (0.4); 1.8257 (0.6); 1.8145 (0.7); 1.8047 (0.6); 1.7925 (0.6); 1.7816 (0.6); 1.7700 (0.4); 1.6010 (0.6); 1.5499 (63.7); 1.5012 (0.6); 0.0000 (11.2) I.1-056: 1 H-NMR (400.1 MHz, d6-DMSO): δ= 10.8047 (0.8); 7.3597 (0.5); 7.3554 (0.6); 7.3494 (0.4); 7.3393 (0.4); 7.3335 (0.6); 7.3292 (0.6); 7.3132 (0.3); 7.3092 (0.3); 7.1925 (0.6); 7.1891 (0.6); 7.1797 (0.6); 7.1764 (0.6); 7.1722 (0.5); 7.1684 (0.4); 7.1594 (0.4); 7.1559 (0.4); 7.0987 (0.6); 7.0825 (0.8); 7.0637 (0.4); 4.7545 (0.9); 4.7142 (1.0); 4.3051 (1.1); 4.2654 (1.0); 3.9296 (0.4); 3.9189 (0.5); 3.9091 (0.6); 3.8992 (0.5); 3.8886 (0.4); 3.3273 (29.0); 3.1686 (0.6); 2.9026 (0.6); 2.8921 (0.6); 2.8652 (0.7); 2.8547 (0.7); 2.6067 (0.7); 2.5852 (0.7); 2.5689 (0.6); 2.5472 (0.8); 2.5401 (0.4); 2.5233 (0.8); 2.5185 (1.2); 2.5100 (17.2); 2.5055 (37.2); 2.5008 (51.8); 2.4963 (37.8); 2.4918 (18.8); 2.4465 (0.5); 2.4223 (0.7); 2.4041 (0.6); 2.3994 (0.6); 2.3825 (0.4); 2.3321 (0.6); 2.3280 (0.4); 2.3190 (0.6); 2.3079 (0.8); 2.2951 (0.8); 2.2687 (16.0); 2.2564 (1.1); 2.2398 (0.6); 2.2279 (0.5); 2.2214 (0.4); 2.2093 (0.6); 2.1898 (0.4); 2.1847 (0.4); 1.8520 (0.4); 1.8404 (0.5); 1.8300 (0.4); 1.8225 (0.5); 1.8096 (0.4); 1.1588 (0.4) I.1-057: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.3344 (5.4); 7.3292 (1.8); 7.3174 (1.8); 7.3120 (6.2); 7.3031 (0.6); 7.1299 (1.9); 7.1094 (7.6); 7.0967 (8.1); 7.0761 (1.9); 6.9719 (0.6); 6.9632 (6.0); 6.9580 (1.9); 6.9462 (1.7); 6.9408 (5.4); 4.6497 (2.0); 4.6116 (2.3); 4.3234 (1.2); 4.3131 (3.2); 4.3032 (3.2); 4.2938 (1.6); 4.1501 (3.1); 4.1388 (4.5); 4.1278 (2.4); 4.0492 (2.3); 4.0111 (2.1); 3.7237 (0.7); 3.7131 (1.1); 3.7028 (1.2); 3.6927 (1.1); 3.6822 (0.8); 3.4331 (6.7); 2.7809 (1.3); 2.7708 (1.3); 2.7411 (1.7); 2.7310 (1.6); 2.5061 (18.9); 2.5018 (25.9); 2.4975 (19.1); 2.4782 (1.8); 2.4564 (1.7); 2.4384 (1.4); 2.4310 (0.5); 2.4166 (1.6); 2.4065 (0.6); 2.3887 (1.2); 2.3706 (0.9); 2.3651 (0.9); 2.3471 (0.8); 2.2631 (16.0); 2.2485 (1.3); 2.2345 (1.2); 2.2066 (0.7); 2.1932 (0.7); 2.1336 (0.7); 2.1208 (0.6); 2.1151 (0.5); 2.1087 (0.6); 2.1022 (0.9); 2.0831 (0.5); 2.0774 (0.6); 1.7120 (0.7); 1.7004 (0.8); 1.6892 (0.7); 1.6801 (0.7); 1.6686 (0.7); 1.6564 (0.5) I.1-058: 1 H-NMR (400.1 MHz, d 6 -DMSO): δ= 7.5589 (2.7); 7.5544 (3.4); 7.5384 (4.3); 7.5334 (4.0); 7.3988 (4.8); 7.3785 (4.1); 7.3562 (1.0); 7.3360 (1.1); 7.3116 (0.8); 7.2081 (0.6); 7.1879 (1.1); 7.1764 (1.1); 7.1545 (0.6); 7.0864 (0.7); 7.0631 (1.2); 7.0577 (0.8); 4.7215 (0.8); 4.7116 (1.0); 4.6810 (1.0); 4.6709 (1.0); 4.3054 (0.3); 4.2746 (1.5); 4.2625 (2.1); 4.2557 (2.8); 4.2503 (1.9); 4.2446 (1.7); 4.2315 (1.8); 4.2204 (0.6); 4.1930 (1.3); 4.0877 (0.6); 4.0744 (0.6); 3.7487 (0.9); 3.7366 (0.9); 3.7194 (0.6); 3.4608 (0.9); 3.4103 (1.4); 3.3630 (9.7); 3.3123 (1240.8); 3.2884 (22.2); 3.2619 (8.4); 3.2432 (0.9); 3.2298 (1.2); 3.2139 (2.2); 3.2093 (0.6); 3.1956 (1.2); 3.1910 (0.9); 3.1753 (2.9); 3.1622 (2.3); 3.0761 (0.7); 3.0673 (1.2); 3.0544 (0.7); 3.0481 (0.8); 3.0412 (0.6); 3.0327 (0.8); 3.0134 (0.5); 2.9124 (0.4); 2.6973 (0.8); 2.6875 (1.4); 2.6787 (1.6); 2.6741 (2.1); 2.6697 (2.8); 2.6647 (2.1); 2.6574 (1.4); 2.6477 (2.0); 2.6375 (1.0); 2.5989 (0.7); 2.5948 (0.8); 2.5600 (2.4); 2.5558 (3.2); 2.5513 (3.4); 2.5466 (1.5); 2.5228 (4.0); 2.5182 (6.8); 2.5096 (153.0); 2.5051 (339.6); 2.5005 (481.2); 2.4959 (349.1); 2.4913 (165.5); 2.4592 (1.8); 2.4545 (2.7); 2.4501 (4.0); 2.4458 (3.5); 2.4410 (2.4); 2.4320 (2.1); 2.4201 (1.6); 2.4119 (2.1); 2.3986 (1.3); 2.3920 (1.4); 2.3793 (1.2); 2.3643 (16.0); 2.3492 (1.3); 2.3364 (1.1); 2.3320 (2.1); 2.3273 (2.9); 2.3229 (2.1); 2.2906 (0.8); 2.2778 (0.9); 2.2662 (1.3); 2.2536 (1.4); 2.2246 (0.9); 2.2136 (1.2); 2.1977 (0.7); 2.1852 (0.7); 2.1599 (0.8); 2.1408 (0.7); 2.1175 (0.4); 2.0722 (2.2); 1.7320 (0.6); 1.7230 (0.6); 1.7119 (0.8); 1.7010 (0.8); 1.6928 (0.8); 1.6804 (0.6); 1.6692 (0.6); 0.1456 (0.4); 0.0505 (0.8); 0.0080 (2.6); 0.0000 (84.3) I.1-060: 1 H-NMR (400.1 MHz, CDCl3): δ= 7.5205 (0.8); 7.5184 (1.0); 7.3836 (4.8); 7.3802 (6.7); 7.3780 (7.9); 7.3728 (3.4); 7.3647 (6.2); 7.3626 (9.5); 7.3602 (12.8); 7.3158 (3.9); 7.3137 (6.6); 7.3115 (5.7); 7.3064 (3.9); 7.3038 (3.6); 7.2954 (11.8); 7.2935 (11.2); 7.2898 (7.2); 7.2847 (5.3); 7.2726 (17.3); 7.2687 (14.4); 7.2679 (14.2); 7.2617 (127.9); 7.2596 (163.4); 7.2520 (4.3); 7.2374 (4.0); 7.2350 (4.6); 7.2317 (2.6); 7.2225 (2.2); 7.2181 (5.5); 7.2014 (1.6); 7.1987 (1.6); 7.1957 (0.7); 6.9979 (5.7); 6.9803 (6.2); 6.9662 (3.2); 6.9599 (3.8); 6.9357 (3.6); 6.9308 (3.4); 6.9066 (3.3); 4.8227 (5.4); 4.7839 (6.0); 4.2467 (0.8); 4.2355 (7.4); 4.2185 (15.0); 4.2017 (7.6); 4.1191 (5.9); 4.0805 (5.4); 3.8792 (1.0); 3.8677 (2.0); 3.8583 (2.8); 3.8475 (3.6); 3.8370 (2.7); 3.8267 (1.9); 3.8156 (0.9); 3.1215 (1.1); 3.1097 (8.5); 3.0929 (16.0); 3.0761 (7.5); 2.5906 (3.5); 2.5797 (3.2); 2.5516 (4.9); 2.5411 (5.3); 2.5171 (3.0); 2.4986 (2.8); 2.4934 (2.6); 2.4747 (2.6); 2.4569 (2.3); 2.4421 (2.7); 2.4326 (3.1); 2.4179 (3.1); 2.3993 (1.0); 2.3896 (1.4); 2.3751 (1.3); 2.3281 (4.4); 2.3068 (4.4); 2.2966 (1.6); 2.2891 (3.6); 2.2781 (2.4); 2.2677 (4.0); 2.2581 (1.6); 2.2539 (1.8); 2.2455 (2.3); 2.2343 (1.1); 2.2256 (1.4); 2.2214 (1.7); 2.2014 (0.8); 1.8383 (1.2); 1.8264 (1.8); 1.8142 (2.1); 1.8051 (2.1); 1.8026 (2.0); 1.7933 (1.9); 1.7908 (2.0); 1.7814 (1.7); 1.7696 (1.3); 1.7558 (0.8); 1.5457 (59.1); 0.1465 (0.3); 0.0128 (4.6); 0.0081 (5.4); 0.0022 (47.7) I.1-063: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.6522 (1.8); 7.3660 (0.5); 7.3440 (0.5); 7.1951 (0.6); 7.1916 (0.6); 7.1822 (0.5); 7.1791 (0.6); 7.0874 (0.6); 7.0714 (0.8); 4.7420 (0.8); 4.7023 (1.0); 4.2438 (1.1); 4.2040 (0.9); 3.7934 (0.6); 3.7833 (0.7); 3.7732 (0.6); 3.5596 (16.0); 2.5201 (0.8); 2.5114 (10.1); 2.5068 (20.3); 2.5023 (28.0); 2.4977 (19.8); 2.4932 (8.8); 2.4767 (1.0); 2.4654 (0.7); 2.3728 (0.6); 2.3527 (0.6); 2.3297 (0.6); 2.2782 (0.5); 2.2670 (0.6); 2.2542 (0.6); 2.1999 (0.9); 2.1782 (0.8); 2.1650 (0.8); 2.1431 (0.9); 1.3492 (1.4); 1.3385 (1.4); 1.3292 (1.3); 1.1744 (0.7); 0.9786 (0.7); 0.9733 (1.3); 0.9694 (1.8); 0.9612 (1.6); 0.9516 (0.5); -0.0002 (5.4) I.1-066: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 7.3541 (0.8); 7.3510 (1.4); 7.3471 (0.6); 7.3382 (0.9); 7.3338 (3.7); 7.3302 (2.0); 7.3185 (1.3); 7.3151 (3.2); 7.3133 (2.2); 7.3100 (0.6); 7.2830 (0.6); 7.2794 (1.4); 7.2759 (1.0); 7.2612 (1.7); 7.2430 (0.6); 7.2260 (2.6); 7.2223 (3.2); 7.2170 (0.7); 7.2054 (2.3); 4.6882 (1.6); 4.6495 (1.8); 4.1239 (1.8); 4.0852 (1.6); 4.0367 (1.4); 4.0194 (4.2); 4.0189 (4.3); 4.0015 (4.6); 3.9837 (1.7); 3.9423 (1.5); 3.7579 (0.6); 3.7473 (0.9); 3.7372 (1.0); 3.7271 (0.9); 3.7166 (0.6); 3.4648 (0.5); 3.4473 (1.6); 3.4298 (1.6); 3.4123 (0.5); 2.7387 (1.3); 2.7283 (1.3); 2.6990 (1.7); 2.6887 (1.6); 2.5192 (0.6); 2.5105 (8.6); 2.5059 (18.5); 2.5013 (25.8); 2.4967 (18.0); 2.4921 (8.0); 2.4473 (2.1); 2.4307 (0.5); 2.4256 (2.2); 2.4076 (2.3); 2.3859 (1.9); 2.3662 (0.6); 2.3064 (0.7); 2.2926 (0.8); 2.2819 (1.1); 2.2682 (1.1); 2.2648 (0.5); 2.2401 (0.7); 2.2269 (0.7); 2.1761 (0.6); 2.1641 (0.6); 2.1460 (0.7); 1.7250 (0.5); 1.7140 (0.8); 1.7032 (0.5); 1.6936 (0.6); 1.6821 (0.7); 1.1488 (7.2); 1.1311 (16.0); 1.1133 (7.1); 1.0727 (1.6); 1.0552 (3.3); 1.0377 (1.6); - 0.0002 (2.3) I.1-067: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.9605 (3.6); 7.3729 (1.6); 7.3521 (3.5); 7.3305 (3.5); 7.3096 (1.9); 7.2064 (2.1); 7.2023 (2.2); 7.1936 (2.1); 7.1865 (3.8); 7.1826 (3.9); 7.1737 (3.7); 7.1701 (4.0); 7.1661 (2.5); 7.1620 (2.3); 7.1533 (2.1); 7.1495 (2.2); 7.0734 (3.7); 7.0576 (5.1); 7.0381 (2.7); 4.7356 (6.1); 4.6957 (7.1); 4.6274 (1.2); 4.2328 (7.4); 4.1925 (6.3); 3.8088 (1.2); 3.7985 (2.3); 3.7883 (3.5); 3.7780 (4.3); 3.7677 (3.6); 3.7572 (2.5); 3.7464 (1.3); 3.3775 (6.7); 3.3624 (14.5); 3.3474 (8.9); 3.3072 (176.5); 3.2559 (1.6); 3.1685 (0.8); 3.1067 (6.0); 3.0920 (16.0); 3.0774 (14.8); 3.0624 (4.8); 2.6739 (2.1); 2.6692 (3.0); 2.6646 (2.1); 2.5395 (2.4); 2.5229 (11.1); 2.5180 (10.8); 2.5094 (174.1); 2.5048 (381.4); 2.5001 (535.0); 2.4955 (370.0); 2.4909 (167.8); 2.4771 (8.4); 2.4502 (2.1); 2.4038 (1.4); 2.3992 (0.5); 2.3855 (2.4); 2.3620 (4.6); 2.3424 (4.2); 2.3316 (2.6); 2.3269 (3.6); 2.3193 (4.0); 2.2776 (3.3); 2.2645 (4.2); 2.2535 (5.2); 2.2406 (4.9); 2.2358 (2.3); 2.2229 (2.1); 2.2124 (8.5); 2.1989 (3.3); 2.1911 (6.4); 2.1779 (5.5); 2.1564 (5.3); 2.1397 (1.9); 2.1202 (3.2); 2.1158 (2.0); 2.1082 (2.3); 2.1010 (2.0); 2.0963 (2.8); 2.0887 (3.9); 2.0770 (1.5); 2.0689 (2.3); 2.0646 (3.0); 2.0451 (1.3); 1.7806 (1.6); 1.7684 (2.2); 1.7572 (3.2); 1.7474 (2.7); 1.7351 (2.7); 1.7253 (2.8); 1.7145 (1.8); 1.7019 (1.2); 0.0080 (1.6); -0.0002 (56.0); -0.0086 (1.8) I.1-069: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 7.1539 (8.0); 7.1387 (6.8); 3.3493 (12.3); 3.3156 (1369.1); 2.6743 (9.8); 2.6696 (14.6); 2.6651 (9.8); 2.5680 (6.2); 2.5390 (19.6); 2.5342 (27.3); 2.5295 (24.1); 2.5233 (41.0); 2.5184 (58.1); 2.5098 (820.2); 2.5053 (1776.1); 2.5007 (2460.2); 2.4961 (1716.3); 2.4915 (763.2); 2.4506 (5.4); 2.3322 (10.2); 2.3275 (14.2); 2.3229 (10.0); 2.0733 (4.4); 1.1833 (8.0); 1.1644 (16.0); 1.1457 (6.6); 0.8936 (8.6); 0.8775 (7.7); 0.8290 (8.3); 0.8125 (7.9); 0.0081 (9.8); -0.0002 (271.7); -0.0086 (6.8) I.1-070: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.9991 (2.5); 8.6323 (0.9); 8.6127 (0.9); 7.4148 (2.3); 7.3595 (0.7); 7.3369 (0.7); 7.1847 (0.7); 7.1725 (0.8); 7.0691 (0.7); 7.0525 (1.0); 4.7152 (1.0); 4.6759 (1.2); 4.6198 (0.5); 4.6103 (0.6); 4.6002 (0.6); 4.5906 (0.5); 4.1730 (1.2); 4.1329 (1.1); 3.7207 (0.6); 3.7100 (0.7); 3.6996 (0.6); 3.6313 (16.0); 3.3542 (134.1); 3.1857 (2.8); 3.1678 (3.3); 3.1510 (0.8); 3.1263 (1.0); 3.1128 (0.9); 3.0374 (1.0); 3.0141 (1.0); 3.0000 (0.7); 2.9763 (0.6); 2.6749 (0.6); 2.6703 (0.8); 2.6656 (0.6); 2.5407 (1.0); 2.5318 (1.2); 2.5238 (2.1); 2.5191 (3.0); 2.5104 (49.9); 2.5058 (108.6); 2.5012 (151.6); 2.4966 (106.3); 2.4920 (47.2); 2.3326 (0.7); 2.3279 (1.1); 2.3232 (1.3); 2.3027 (0.9); 2.2802 (0.7); 2.2720 (1.0); 2.2594 (0.6); 2.2499 (1.1); 2.2362 (1.3); 2.2226 (0.9); 2.2156 (1.0); 2.0292 (0.6); 1.7013 (0.5); 1.6913 (0.5); 0.0080 (0.5); -0.0002 (16.5) I.1-073: 1 H-NMR (400.1 MHz, CDCl3): δ= 17.2398 (0.3); 15.8901 (0.6); 13.9985 (0.3); 7.5185 (3.1); 7.3594 (0.5); 7.3160 (2.6); 7.2977 (5.6); 7.2797 (7.0); 7.2756 (5.4); 7.2598 (550.1); 7.2109 (1.1); 7.1584 (0.4); 7.1530 (0.3); 7.0340 (9.7); 7.0150 (8.7); 6.9950 (4.6); 6.9872 (4.8); 6.9689 (16.0); 6.9464 (13.2); 6.7610 (0.3); 5.5547 (0.4); 5.5395 (0.4); 5.5336 (0.4); 5.5086 (0.7); 5.4873 (1.0); 5.4517 (2.3); 5.4223 (1.6); 5.3933 (1.1); 5.3354 (2.2); 4.8824 (0.4); 4.7450 (11.0); 4.7067 (12.8); 4.2529 (12.2); 4.2145 (10.7); 4.1782 (0.6); 4.1329 (0.3); 4.0453 (2.0); 4.0335 (3.8); 4.0246 (4.4); 4.0132 (7.2); 4.0017 (4.6); 3.9934 (4.1); 3.9814 (2.0); 3.5288 (1.0); 3.4919 (1.4); 2.6255 (0.4); 2.5928 (1.7); 2.5696 (10.0); 2.5575 (8.2); 2.5500 (6.7); 2.5320 (14.2); 2.5201 (10.5); 2.5071 (5.2); 2.4921 (4.9); 2.4776 (5.5); 2.4678 (6.6); 2.4537 (6.9); 2.4350 (1.9); 2.4249 (3.1); 2.4109 (3.4); 2.3933 (0.4); 2.3869 (0.4); 2.3709 (0.4); 2.3588 (2.7); 2.3394 (4.4); 2.3261 (3.2); 2.3205 (2.9); 2.3155 (3.6); 2.3069 (4.9); 2.3020 (3.3); 2.2970 (2.2); 2.2879 (2.9); 2.2830 (4.1); 2.2637 (2.0); 2.2485 (0.4); 2.2262 (9.5); 2.2053 (9.4); 2.1888 (7.9); 2.1678 (7.8); 2.0838 (0.6); 2.0236 (0.9); 2.0138 (1.0); 2.0047 (1.2); 1.8513 (15.7); 1.8395 (14.3); 1.8270 (12.0); 1.8174 (10.1); 1.8042 (8.3); 1.7941 (6.6); 1.7831 (5.3); 1.7694 (3.8); 1.7045 (0.9); 1.6337 (0.5); 1.6220 (0.5); 1.5953 (0.5); 1.5880 (0.4); 1.5504 (0.4); 1.2244 (0.3); 0.9752 (0.3); 0.8624 (0.3); 0.8237 (0.3); 0.1455 (1.0); 0.0999 (0.4); 0.0082 (6.5); 0.0000 (199.3) I.1-074: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.3499 (4.6); 7.3263 (3.6); 7.2640 (9.4); 7.2465 (15.0); 7.2290 (11.4); 7.2168 (13.4); 7.2108 (16.0); 7.1858 (10.8); 7.0363 (4.8); 7.0215 (5.0); 4.6966 (3.6); 4.6769 (3.8); 4.6572 (4.0); 4.6371 (4.5); 4.1809 (3.8); 4.1394 (4.0); 4.1246 (4.5); 4.0843 (3.8); 3.6475 (3.2); 3.3671 (5.4); 3.3151 (6348.8); 3.2642 (17.1); 3.2158 (5.8); 3.1660 (9.5); 3.0520 (4.0); 2.8323 (3.3); 2.8073 (3.9); 2.6744 (25.2); 2.6697 (35.0); 2.6652 (25.8); 2.6607 (11.2); 2.5400 (23.0); 2.5232 (95.7); 2.5185 (141.3); 2.5098 (1948.2); 2.5053 (4233.3); 2.5007 (5926.9); 2.4960 (4148.6); 2.4915 (1849.1); 2.4552 (12.4); 2.4502 (15.1); 2.4457 (12.4); 2.4059 (5.9); 2.3368 (11.6); 2.3321 (24.8); 2.3275 (34.9); 2.3228 (25.0); 2.3185 (12.0); 2.2696 (4.0); 2.2469 (4.7); 2.2272 (4.7); 2.1878 (5.4); 2.1724 (6.5); 2.1649 (6.7); 2.1537 (6.4); 2.0730 (8.0); 0.0080 (20.9); -0.0002 (707.7); -0.0085 (19.0) I.1-075: 1 H-NMR (400.1 MHz, CDCl 3 ): δ= 10.3385 (0.3); 10.3199 (0.4); 7.5193 (1.3); 7.3089 (0.8); 7.2605 (246.9); 7.2126 (0.7); 7.1463 (2.1); 7.1417 (2.4); 7.1220 (7.3); 7.1076 (5.8); 7.1027 (9.1); 7.0973 (6.6); 7.0850 (8.0); 7.0764 (9.5); 7.0680 (9.5); 7.0562 (11.3); 7.0474 (6.5); 7.0363 (6.7); 7.0249 (8.1); 7.0092 (8.8); 6.9966 (4.3); 6.9921 (4.0); 6.7516 (0.5); 5.2983 (4.6); 4.9233 (0.5); 4.8772 (10.9); 4.8384 (12.5); 4.7961 (0.9); 4.3589 (0.4); 4.3341 (1.0); 4.2956 (1.0); 4.2232 (14.4); 4.2064 (1.3); 4.1846 (13.2); 4.1353 (0.9); 4.1194 (0.8); 4.0975 (0.8); 4.0467 (1.3); 4.0344 (1.4); 4.0260 (1.4); 4.0151 (1.4); 3.9968 (3.2); 3.9869 (5.4); 3.9768 (7.7); 3.9668 (9.7); 3.9566 (8.1); 3.9465 (5.9); 3.9367 (3.6); 3.9159 (1.7); 3.9051 (1.7); 3.8947 (1.8); 3.8870 (1.7); 3.8757 (1.7); 3.8439 (1.6); 3.8166 (1.5); 3.8102 (1.5); 3.7902 (1.5); 3.7877 (1.4); 3.7380 (1.3); 3.7195 (1.4); 3.6994 (1.5); 3.6715 (1.5); 3.6530 (1.3); 3.6347 (1.0); 3.6173 (0.8); 3.6084 (0.9); 3.5958 (0.8); 3.5761 (0.8); 3.5599 (0.8); 3.5008 (1.7); 3.4986 (1.7); 3.4934 (2.5); 3.4103 (0.5); 3.3407 (0.9); 3.3205 (0.9); 3.3031 (1.3); 3.2851 (1.9); 3.2672 (2.2); 3.2433 (1.6); 3.1611 (0.3); 3.1358 (1.1); 3.1129 (2.4); 3.1073 (2.3); 3.0368 (0.6); 3.0262 (0.6); 2.9948 (0.6); 2.9840 (0.6); 2.8921 (9.3); 2.8814 (12.8); 2.8768 (13.6); 2.8678 (13.0); 2.8518 (16.0); 2.8415 (12.0); 2.7276 (0.4); 2.7179 (0.8); 2.6992 (0.6); 2.6872 (0.8); 2.6773 (1.1); 2.6563 (11.2); 2.6360 (10.9); 2.6157 (8.6); 2.5955 (10.2); 2.5740 (4.2); 2.5532 (7.4); 2.5315 (8.1); 2.5098 (5.6); 2.4834 (5.0); 2.4711 (6.2); 2.4588 (7.7); 2.4467 (8.0); 2.4406 (3.6); 2.4280 (2.6); 2.4154 (4.0); 2.4036 (4.2); 2.3615 (3.1); 2.3414 (5.3); 2.3288 (3.9); 2.3172 (4.6); 2.3087 (6.2); 2.2971 (2.6); 2.2842 (4.8); 2.2637 (2.0); 2.1833 (0.3); 2.1053 (0.6); 2.0883 (1.7); 2.0689 (2.2); 2.0523 (1.9); 2.0358 (1.0); 2.0077 (1.2); 1.9291 (2.6); 1.9180 (4.4); 1.9066 (4.6); 1.8957 (5.8); 1.8845 (6.1); 1.8739 (4.1); 1.8616 (3.3); 1.8508 (2.2); 1.8346 (0.5); 1.8211 (0.4); 1.8151 (0.4); 1.8012 (0.3); 1.7888 (0.3); 1.3069 (0.6); 1.2888 (1.1); 1.2698 (0.9); 1.2520 (2.9); 1.2339 (4.4); 1.2167 (2.2); 1.1938 (2.2); 1.1757 (4.4); 1.1635 (0.4); 1.1574 (2.0); 1.1493 (0.5); 0.0082 (1.4) I.1-076: 1 H-NMR (400.1 MHz, CDCl3): δ= 7.3161 (0.4); 7.2997 (1.0); 7.2835 (1.1); 7.2606 (55.8); 7.0377 (1.2); 7.0187 (1.1); 6.9961 (0.5); 6.9904 (0.7); 6.9835 (0.7); 6.9635 (2.2); 6.9414 (1.8); 4.8362 (0.4); 4.7974 (0.5); 4.6048 (1.3); 4.5660 (1.9); 4.4097 (1.7); 4.3712 (1.2); 4.1380 (0.5); 4.1015 (0.8); 4.0939 (0.6); 4.0823 (1.1); 4.0708 (0.6); 4.0627 (0.6); 3.6477 (4.5); 3.1311 (15.8); 3.0571 (16.0); 2.9488 (2.6); 2.9164 (0.9); 2.9048 (1.0); 2.8739 (1.3); 2.8621 (1.3); 2.8483 (1.3); 2.8349 (1.3); 2.6712 (1.3); 2.6516 (1.3); 2.6411 (0.3); 2.6290 (1.2); 2.6089 (1.0); 2.6024 (0.5); 2.5905 (0.5); 2.5819 (0.3); 2.5636 (0.9); 2.5449 (0.7); 2.5397 (0.7); 2.5219 (0.7); 2.4921 (0.7); 2.4779 (0.7); 2.4683 (1.0); 2.4541 (1.1); 2.4455 (0.3); 2.4308 (0.3); 2.4253 (0.5); 2.4118 (0.6); 2.3878 (0.8); 2.3697 (0.6); 2.3658 (0.6); 2.3563 (0.4); 2.3474 (0.6); 2.3375 (0.6); 2.3325 (0.4); 2.3271 (0.5); 2.3180 (0.4); 2.3131 (0.4); 2.0039 (0.4); 1.8359 (0.3); 1.8234 (0.5); 1.8116 (0.6); 1.8031 (0.5); 1.7909 (0.5); 1.7793 (0.5); 1.7677 (0.4); 1.5562 (47.4) I.1-078: 1 H-NMR (400.1 MHz, d 6 -DMSO): δ= 7.8196 (0.5); 7.8124 (3.8); 7.8072 (1.1); 7.7951 (1.2); 7.7900 (4.2); 7.7827 (0.4); 7.3591 (0.5); 7.3374 (0.6); 7.3173 (0.4); 7.1875 (0.6); 7.1706 (0.9); 7.1641 (4.3); 7.1589 (1.2); 7.1470 (1.1); 7.1417 (3.7); 7.1341 (0.3); 7.0421 (0.6); 7.0285 (0.8); 7.0072 (0.4); 4.6716 (0.8); 4.6322 (1.1); 4.2422 (1.3); 4.2277 (2.7); 4.2137 (1.5); 4.1731 (1.2); 4.1319 (1.0); 4.0736 (0.3); 3.8581 (0.4); 3.8474 (16.0); 3.6939 (0.3); 3.6832 (0.4); 3.6731 (0.6); 3.6627 (0.8); 3.6537 (0.7); 3.6411 (0.5); 3.6304 (1.3); 3.6176 (1.9); 3.6135 (2.0); 3.6027 (0.9); 3.3624 (2.6); 3.3115 (801.9); 3.2877 (13.5); 3.2626 (2.3); 3.2118 (0.4); 3.1752 (1.4); 3.1621 (1.4); 2.6786 (0.7); 2.6741 (1.2); 2.6696 (1.8); 2.6649 (1.3); 2.6606 (0.7); 2.5622 (1.1); 2.5518 (1.9); 2.5399 (1.4); 2.5230 (4.1); 2.5183 (5.3); 2.5097 (103.1); 2.5051 (228.6); 2.5005 (323.1); 2.4959 (232.4); 2.4913 (109.4); 2.3902 (0.4); 2.3715 (0.4); 2.3480 (0.6); 2.3318 (1.5); 2.3275 (2.4); 2.3228 (1.8); 2.3055 (0.6); 2.2704 (1.1); 2.2652 (0.6); 2.2496 (1.2); 2.2410 (0.8); 2.2300 (1.2); 2.2096 (0.9); 2.1987 (0.4); 2.1859 (0.4); 2.1609 (0.4); 2.1419 (0.4); 2.1291 (0.3); 2.1172 (0.4); 2.1106 (0.5); 2.0911 (0.4); 2.0857 (0.4); 2.0720 (1.1); 1.6402 (0.4); 1.6295 (0.5); 1.6173 (0.5); 1.6068 (0.4); 1.5968 (0.4); 1.5839 (0.3); 0.0081 (1.8) I.1-080: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.1482 (1.1); 7.1276 (7.2); 7.1217 (6.5); 7.1159 (2.8); 7.1094 (1.1); 7.1003 (1.0); 4.6978 (1.1); 4.6803 (0.6); 4.6602 (1.1); 4.6404 (0.6); 4.0401 (1.0); 4.0332 (0.6); 4.0025 (1.0); 3.9937 (0.7); 3.7296 (0.5); 3.7193 (0.6); 3.7089 (0.6); 3.6982 (0.6); 3.5533 (0.5); 3.4387 (11.3); 3.1677 (16.0); 2.8641 (0.6); 2.8542 (0.6); 2.8246 (0.9); 2.8148 (1.0); 2.6792 (0.6); 2.6699 (0.6); 2.6492 (0.6); 2.6394 (0.6); 2.5641 (1.0); 2.5423 (1.2); 2.5236 (1.8); 2.5187 (2.2); 2.5101 (33.5); 2.5055 (72.8); 2.5009 (101.7); 2.4962 (70.1); 2.4916 (30.6); 2.4217 (1.3); 2.4043 (0.8); 2.3737 (0.8); 2.3596 (0.7); 2.3430 (0.6); 2.3324 (0.6); 2.3277 (0.7); 2.3230 (0.6); 2.2759 (12.8); 2.2644 (1.8); 2.2545 (1.8); 2.2380 (1.5); 2.2100 (0.6); 2.1434 (0.6); 2.1311 (0.5); 2.1249 (0.6); 2.1188 (0.5); 2.1135 (0.6); 2.0994 (0.9); 2.0835 (0.6); 1.6971 (0.6); 1.6515 (0.8); 1.5603 (2.3); 1.5530 (1.9); -0.0002 (8.5) I.1-082: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.4699 (1.6); 8.4559 (3.0); 8.4411 (1.6); 7.3769 (1.1); 7.3560 (2.4); 7.3303 (4.7); 7.3282 (4.6); 7.3131 (6.4); 7.3089 (11.2); 7.2963 (3.3); 7.2916 (8.8); 7.2494 (3.7); 7.2465 (3.9); 7.2324 (16.0); 7.2124 (9.7); 7.1939 (1.4); 7.1867 (2.5); 7.1831 (2.6); 7.1706 (2.6); 7.1625 (1.5); 7.1536 (1.3); 7.1502 (1.4); 7.0799 (2.5); 7.0635 (3.4); 7.0444 (1.8); 4.7432 (3.9); 4.7038 (4.6); 4.2954 (1.0); 4.2805 (1.0); 4.2579 (4.8); 4.2411 (12.0); 4.2261 (5.0); 4.2003 (4.7); 4.1884 (1.1); 3.8472 (0.8); 3.8358 (1.6); 3.8257 (2.3); 3.8153 (2.8); 3.8055 (2.3); 3.7948 (1.7); 3.7840 (0.8); 3.3773 (0.6); 3.3248 (216.2); 3.2761 (1.0); 2.6743 (0.6); 2.6697 (0.9); 2.6650 (0.6); 2.6087 (3.2); 2.5975 (3.2); 2.5736 (3.9); 2.5624 (3.9); 2.5230 (2.3); 2.5097 (54.9); 2.5052 (116.5); 2.5006 (160.4); 2.4960 (112.7); 2.4915 (51.7); 2.4555 (0.8); 2.4024 (0.9); 2.3790 (1.3); 2.3597 (2.8); 2.3372 (2.8); 2.3275 (1.2); 2.3181 (2.5); 2.2862 (5.6); 2.2739 (2.7); 2.2637 (6.6); 2.2505 (6.1); 2.2292 (3.6); 2.2213 (1.8); 2.2085 (1.7); 2.1620 (1.2); 2.1429 (2.0); 2.1305 (1.4); 2.1235 (1.3); 2.1190 (1.7); 2.1114 (2.4); 2.0996 (0.9); 2.0918 (1.4); 2.0874 (1.8); 2.0675 (0.7); 1.7986 (1.0); 1.7867 (1.5); 1.7753 (2.0); 1.7652 (1.8); 1.7543 (1.7); 1.7436 (1.9); 1.7326 (1.1); 1.7199 (0.8); -0.0002 (13.6) I.1-083: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.2319 (0.8); 7.2130 (1.8); 7.1942 (1.2); 7.0829 (1.0); 7.0641 (0.8); 7.0176 (1.8); 6.9881 (0.8); 4.6556 (1.2); 4.6173 (1.3); 4.0613 (1.2); 4.0234 (1.1); 3.7337 (0.7); 3.7231 (0.7); 3.7128 (0.6); 3.7021 (0.5); 3.5530 (16.0); 3.3290 (35.8); 2.7590 (0.8); 2.7487 (0.8); 2.7191 (1.1); 2.7088 (1.0); 2.6709 (0.7); 2.5460 (0.5); 2.5410 (0.6); 2.5242 (1.0); 2.5195 (2.0); 2.5108 (38.5); 2.5063 (84.9); 2.5017 (118.5); 2.4971 (84.1); 2.4926 (38.4); 2.4609 (1.2); 2.4479 (0.5); 2.4391 (1.2); 2.4214 (1.0); 2.4059 (0.8); 2.3993 (1.0); 2.3877 (0.5); 2.3329 (0.6); 2.3285 (0.8); 2.3020 (0.6); 2.2844 (9.6); 2.2641 (0.8); 2.2358 (0.5); 2.1325 (0.6); 1.7011 (0.6); 0.0080 (0.6); -0.0002 (21.7); -0.0085 (0.7) I.1-084: 1 H-NMR (400.0 MHz, CDCl3): δ= 7.2602 (57.9); 7.2110 (1.0); 7.1922 (2.4); 7.1734 (1.5); 7.1096 (25.3); 7.0586 (1.3); 7.0396 (1.0); 6.9693 (2.0); 6.9526 (1.2); 6.9326 (1.0); 5.2824 (0.6); 4.7082 (1.7); 4.6707 (2.0); 4.1098 (1.8); 4.0722 (1.6); 3.9416 (0.6); 3.9310 (0.7); 3.9209 (1.0); 3.9109 (0.7); 3.9003 (0.7); 3.5034 (0.8); 3.4857 (1.2); 3.4706 (1.1); 3.4649 (0.6); 3.4532 (0.6); 3.4474 (1.1); 3.4328 (1.2); 3.4156 (0.7); 2.7431 (1.9); 2.7257 (3.8); 2.7084 (1.8); 2.4892 (1.2); 2.4778 (1.3); 2.4616 (0.9); 2.4533 (1.4); 2.4418 (2.1); 2.4192 (0.8); 2.4118 (0.9); 2.3974 (1.0); 2.3876 (1.1); 2.3734 (1.2); 2.3448 (0.6); 2.3267 (12.5); 2.3213 (16.0); 2.1998 (0.7); 2.1866 (0.5); 2.1758 (0.6); 2.1673 (0.9); 2.1625 (0.6); 2.1430 (0.6); 2.0473 (1.5); 2.0259 (1.5); 2.0113 (1.3); 1.9899 (1.3); 1.7553 (0.5); 1.7442 (0.5); 1.7413 (0.6); 1.7306 (0.6); 1.7210 (0.6); 1.7177 (0.5); 1.7082 (0.6); 1.6974 (0.5); -0.0002 (15.0) I.1-085: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.9206 (0.9); 7.3532 (0.9); 7.3373 (0.6); 7.3318 (0.9); 7.2077 (0.5); 7.2037 (0.6); 7.1949 (0.5); 7.1910 (0.6); 7.1878 (1.0); 7.1840 (1.0); 7.1751 (0.9); 7.1714 (1.0); 7.1675 (0.6); 7.1635 (0.6); 7.1546 (0.5); 7.1509 (0.6); 7.0766 (1.0); 7.0606 (1.3); 7.0574 (1.2); 7.0412 (0.7); 4.7386 (1.5); 4.6988 (1.7); 4.2400 (1.9); 4.2006 (1.6); 3.8045 (0.6); 3.7941 (0.8); 3.7838 (1.1); 3.7737 (0.8); 3.7633 (0.6); 3.3076 (49.6); 2.8956 (0.6); 2.8783 (1.6); 2.8613 (1.7); 2.8458 (1.5); 2.8284 (1.5); 2.8120 (1.4); 2.7942 (0.6); 2.5308 (1.4); 2.5229 (1.3); 2.5185 (2.5); 2.5096 (26.9); 2.5050 (59.5); 2.5004 (84.1); 2.4958 (59.9); 2.4912 (26.4); 2.3598 (1.1); 2.3406 (1.0); 2.3368 (1.1); 2.3272 (0.6); 2.3179 (1.0); 2.2882 (0.9); 2.2746 (1.1); 2.2641 (1.3); 2.2507 (1.3); 2.2465 (0.6); 2.2217 (2.1); 2.2090 (0.8); 2.1999 (1.6); 2.1867 (1.3); 2.1652 (1.3); 2.1271 (0.8); 2.1149 (0.6); 2.1032 (0.7); 2.0956 (0.9); 2.0910 (0.6); 2.0762 (0.5); 2.0714 (0.9); 1.7676 (0.6); 1.7566 (0.8); 1.7468 (0.6); 1.7355 (0.6); 1.7249 (0.7); 1.6672 (0.6); 1.6504 (1.2); 1.6336 (1.5); 1.6169 (1.2); 1.6000 (0.6); 0.8217 (16.0); 0.8049 (15.4); -0.0002 (8.6) I.1-086: 1 H-NMR (400.1 MHz, d 6 -DMSO): δ= 7.3971 (7.6); 7.3790 (5.0); 7.3751 (4.6); 7.3584 (7.2); 7.3546 (7.8); 7.3484 (4.0); 7.3385 (4.9); 7.3330 (7.7); 7.3287 (6.4); 7.3122 (4.0); 7.3085 (3.7); 7.2099 (4.0); 7.2061 (4.0); 7.1972 (4.2); 7.1900 (7.8); 7.1864 (7.8); 7.1772 (7.6); 7.1739 (8.0); 7.1699 (4.9); 7.1660 (4.5); 7.1569 (4.1); 7.1536 (4.2); 7.0848 (7.8); 7.0687 (10.9); 7.0494 (5.5); 6.9468 (0.5); 6.8974 (7.5); 4.7474 (12.7); 4.7078 (14.6); 4.2404 (16.0); 4.2179 (0.4); 4.2007 (13.8); 3.8023 (2.5); 3.7915 (5.5); 3.7808 (7.4); 3.7706 (8.6); 3.7605 (7.5); 3.7498 (5.8); 3.7391 (2.8); 3.5598 (0.4); 3.5114 (0.4); 3.4589 (1.4); 3.4218 (1.6); 3.4080 (5.7); 3.3602 (1264.3); 3.3020 (0.4); 3.2922 (1.0); 3.2634 (1.2); 3.2470 (0.4); 3.2326 (0.3); 3.2116 (0.4); 3.1693 (2.2); 2.6794 (1.1); 2.6752 (2.3); 2.6707 (3.2); 2.6662 (2.4); 2.6618 (1.1); 2.6048 (0.4); 2.6001 (0.4); 2.5501 (1.4); 2.5455 (1.8); 2.5410 (2.0); 2.5240 (8.5); 2.5192 (12.0); 2.5106 (195.3); 2.5062 (398.9); 2.5016 (545.9); 2.4971 (389.8); 2.4926 (178.1); 2.4744 (16.3); 2.4633 (14.3); 2.4284 (0.4); 2.4105 (3.2); 2.3914 (4.0); 2.3876 (3.9); 2.3686 (9.0); 2.3494 (8.2); 2.3458 (7.5); 2.3379 (2.0); 2.3327 (3.4); 2.3274 (9.0); 2.3030 (0.4); 2.2872 (6.5); 2.2738 (7.6); 2.2631 (9.8); 2.2498 (9.8); 2.2321 (3.1); 2.2212 (5.4); 2.2083 (5.6); 2.1802 (12.7); 2.1658 (4.5); 2.1579 (12.8); 2.1452 (14.5); 2.1345 (5.2); 2.1227 (15.3); 2.1154 (8.3); 2.1107 (4.6); 2.1037 (2.8); 2.0958 (4.4); 2.0912 (5.6); 2.0716 (3.2); 1.7780 (3.3); 1.7662 (4.8); 1.7548 (6.8); 1.7444 (5.6); 1.7339 (5.5); 1.7231 (5.9); 1.7121 (3.8); 1.6993 (2.6) I.1-087: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 9.5856 (2.2); 8.3724 (6.0); 7.3845 (3.1); 7.3633 (6.6); 7.3372 (6.3); 7.3175 (3.3); 7.2148 (3.8); 7.1953 (6.8); 7.1823 (6.8); 7.1618 (3.8); 7.0942 (2.6); 7.0802 (7.6); 7.0643 (7.4); 7.0453 (3.5); 4.7768 (3.5); 4.7369 (11.2); 4.6970 (8.8); 4.2390 (10.4); 4.1995 (9.5); 3.8528 (16.0); 3.8078 (14.7); 3.7971 (15.2); 3.7870 (15.8); 3.7764 (13.9); 3.1683 (6.6); 2.8096 (2.7); 2.7991 (2.9); 2.7719 (3.7); 2.7612 (3.8); 2.6747 (4.4); 2.6701 (6.0); 2.6658 (4.1); 2.5791 (115.5); 2.5404 (41.5); 2.5236 (16.2); 2.5189 (24.6); 2.5102 (357.0); 2.5057 (776.9); 2.5010 (1082.2); 2.4964 (752.8); 2.4919 (337.9); 2.4648 (7.9); 2.4539 (9.2); 2.4293 (9.1); 2.4186 (8.3); 2.4028 (6.4); 2.3865 (8.1); 2.3655 (14.1); 2.3543 (29.4); 2.3323 (7.1); 2.3276 (10.4); 2.2978 (4.6); 2.2845 (5.8); 2.2734 (8.1); 2.2606 (7.2); 2.2490 (3.8); 2.2318 (4.8); 2.2194 (4.2); 2.1713 (3.4); 2.1577 (7.3); 2.1368 (9.1); 2.1223 (9.1); 2.1010 (7.9); 2.0731 (2.6); 1.7782 (2.2); 1.7661 (2.9); 1.7541 (4.5); 1.7418 (4.2); 1.7222 (4.4); 0.0081 (7.5); -0.0002 (245.9); -0.0086 (6.7) I.1-088: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 7.9528 (0.9); 7.1430 (1.8); 7.1228 (7.4); 7.1092 (8.3); 7.0886 (2.1); 4.6659 (1.9); 4.6279 (2.2); 4.0115 (2.2); 3.9736 (2.0); 3.7157 (0.7); 3.7046 (0.9); 3.6942 (1.0); 3.6841 (0.9); 3.6731 (0.8); 3.3815 (4.2); 3.3663 (9.3); 3.3512 (8.0); 3.1683 (0.8); 3.1147 (0.8); 3.1083 (0.9); 3.1001 (2.2); 3.0932 (2.0); 3.0857 (2.1); 3.0786 (1.9); 3.0711 (0.8); 3.0631 (0.8); 2.6691 (0.5); 2.5226 (0.9); 2.5178 (1.4); 2.5092 (31.9); 2.5046 (68.2); 2.5000 (97.1); 2.4954 (68.6); 2.4908 (31.4); 2.4749 (2.3); 2.4637 (2.0); 2.4507 (0.7); 2.3641 (0.6); 2.3458 (1.1); 2.3268 (1.6); 2.3225 (1.3); 2.3036 (0.9); 2.2756 (16.0); 2.2597 (1.1); 2.2462 (1.2); 2.2355 (1.3); 2.2220 (1.3); 2.2044 (0.6); 2.1936 (0.7); 2.1803 (0.7); 2.1403 (1.7); 2.1176 (1.7); 2.1058 (1.4); 2.0832 (1.4); 2.0710 (0.6); 2.0421 (0.8); 2.0295 (0.6); 2.0179 (0.7); 2.0102 (0.9); 1.9909 (0.5); 1.9860 (0.8); 1.7164 (0.6); 1.7056 (0.8); 1.6956 (0.7); 1.6844 (0.7); 1.6737 (0.7); 0.0080 (0.8); -0.0002 (29.7); -0.0085 (0.9) I.1-089: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 9.8770 (6.5); 7.8843 (0.6); 7.8775 (4.7); 7.8727 (1.6); 7.8557 (5.1); 7.8490 (0.6); 7.2984 (1.2); 7.2768 (1.3); 7.1347 (4.9); 7.1289 (2.8); 7.1128 (6.2); 7.1065 (8.3); 7.0941 (8.0); 7.0734 (1.8); 6.9279 (1.4); 6.9062 (1.3); 5.3173 (1.5); 4.6472 (2.2); 4.6090 (2.4); 4.3686 (0.8); 4.3583 (2.3); 4.3489 (2.8); 4.3399 (1.9); 4.3303 (0.6); 4.3198 (0.9); 4.3090 (1.0); 4.2860 (2.5); 4.2755 (3.1); 4.2653 (1.4); 4.1537 (0.7); 4.1427 (1.1); 4.1315 (0.6); 4.0484 (2.3); 4.0106 (2.0); 3.7273 (0.7); 3.7165 (1.1); 3.7066 (1.3); 3.6956 (1.1); 3.6853 (0.8); 3.3234 (251.7); 3.2069 (12.7); 3.1674 (6.2); 2.7875 (1.2); 2.7773 (1.2); 2.7477 (1.5); 2.7375 (1.5); 2.6704 (0.7); 2.6662 (0.5); 2.5102 (44.1); 2.5058 (92.5); 2.5013 (126.9); 2.4968 (90.5); 2.4924 (42.3); 2.4664 (1.7); 2.4557 (0.7); 2.4483 (1.3); 2.4376 (0.6); 2.4268 (1.6); 2.4108 (0.7); 2.3863 (1.2); 2.3686 (1.0); 2.3452 (0.8); 2.3281 (0.8); 2.2594 (16.0); 2.2459 (1.4); 2.2321 (1.3); 2.2150 (0.5); 2.2041 (0.8); 2.1909 (0.8); 2.1358 (0.7); 2.1230 (0.6); 2.1038 (0.9); 2.0796 (0.7); 1.7160 (0.7); 1.7043 (0.9); 1.6935 (0.8); 1.6837 (0.8); 1.6725 (0.8); 1.6602 (0.6); -0.0002 (5.5) I.1-090: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.2264 (1.5); 8.1026 (5.0); 7.3780 (2.4); 7.3742 (2.4); 7.3577 (5.2); 7.3535 (5.7); 7.3321 (5.7); 7.3114 (2.9); 7.3077 (2.9); 7.2081 (3.3); 7.2041 (3.5); 7.1952 (3.4); 7.1882 (6.2); 7.1842 (6.4); 7.1755 (5.8); 7.1718 (6.5); 7.1677 (3.9); 7.1638 (3.8); 7.1551 (3.2); 7.1511 (3.4); 7.0772 (6.1); 7.0611 (8.3); 7.0419 (4.3); 5.8065 (3.2); 5.7932 (7.2); 5.7804 (5.9); 5.7675 (8.2); 5.7635 (4.0); 5.7543 (3.9); 5.7502 (8.7); 5.7373 (6.9); 5.7245 (8.7); 5.7112 (3.8); 5.1305 (4.3); 5.1261 (13.8); 5.1217 (14.7); 5.1173 (4.9); 5.0875 (4.0); 5.0831 (12.3); 5.0786 (12.9); 5.0742 (4.5); 5.0607 (5.2); 5.0567 (14.4); 5.0525 (13.4); 5.0485 (4.6); 5.0350 (4.8); 5.0310 (13.4); 5.0269 (12.8); 5.0229 (4.2); 4.7416 (9.7); 4.7019 (11.2); 4.2382 (12.1); 4.1985 (10.5); 3.8243 (2.0); 3.8132 (4.1); 3.8028 (5.8); 3.7926 (7.3); 3.7824 (5.8); 3.7722 (4.3); 3.7611 (2.0); 3.7060 (0.8); 3.6836 (3.4); 3.6792 (8.0); 3.6746 (9.0); 3.6698 (10.4); 3.6654 (16.0); 3.6609 (15.9); 3.6563 (10.8); 3.6517 (9.9); 3.6472 (8.5); 3.6428 (3.4); 3.6205 (0.9); 3.4150 (2.1); 3.3183 (241.7); 3.1678 (2.0); 2.6739 (2.0); 2.6694 (2.8); 2.6647 (2.1); 2.5597 (8.6); 2.5482 (8.7); 2.5244 (13.4); 2.5180 (10.9); 2.5095 (164.1); 2.5049 (354.0); 2.5003 (494.5); 2.4957 (343.6); 2.4911 (154.5); 2.4061 (2.6); 2.3871 (3.2); 2.3646 (7.2); 2.3449 (6.4); 2.3316 (2.7); 2.3269 (4.0); 2.3223 (7.4); 2.2878 (5.6); 2.2745 (6.7); 2.2637 (8.3); 2.2504 (9.2); 2.2462 (14.5); 2.2327 (3.4); 2.2246 (11.8); 2.2110 (10.6); 2.1896 (8.9); 2.1552 (3.0); 2.1359 (5.4); 2.1313 (2.9); 2.1237 (3.9); 2.1166 (3.1); 2.1119 (4.4); 2.1043 (6.1); 2.0999 (3.6); 2.0926 (2.4); 2.0849 (3.5); 2.0804 (4.6); 2.0712 (1.4); 2.0607 (2.1); 1.7829 (2.5); 1.7705 (3.8); 1.7596 (5.1); 1.7495 (4.3); 1.7386 (4.1); 1.7279 (4.5); 1.7165 (2.8); 1.7041 (2.0); 0.0080 (4.8); -0.0002 (171.8); -0.0085 (4.9); -0.1496 (0.6) I.1-091: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.0877 (0.8); 7.4625 (3.8); 7.1364 (1.6); 7.1164 (4.3); 7.0942 (4.7); 7.0738 (1.6); 4.6580 (1.2); 4.6198 (1.4); 4.0077 (3.4); 3.9948 (3.4); 3.9802 (5.1); 3.9622 (4.0); 3.9437 (1.8); 3.7060 (0.6); 3.6959 (0.7); 3.6856 (0.6); 3.4138 (12.6); 2.5224 (1.0); 2.5177 (1.5); 2.5091 (23.8); 2.5045 (52.1); 2.4999 (71.8); 2.4953 (50.3); 2.4908 (22.8); 2.4700 (1.2); 2.4589 (1.1); 2.3271 (1.0); 2.3085 (0.7); 2.2854 (0.7); 2.2734 (10.3); 2.2553 (0.6); 2.2418 (0.7); 2.2312 (0.8); 2.2177 (0.8); 2.1694 (0.9); 2.1419 (1.0); 2.1196 (1.0); 2.1074 (0.9); 2.0851 (0.9); 2.0646 (16.0); 2.0405 (0.5); 2.0088 (0.6); 1.6987 (0.5); 1.3094 (4.5); 1.2913 (9.8); 1.2731 (4.4); 0.0080 (0.7); -0.0002 (22.1); -0.0085 (0.6) I.1-092: 1 H-NMR (400.1 MHz, d6-DMSO): δ= 18.0164 (1.4); 13.3388 (1.8); 13.3093 (1.5); 7.8999 (16.0); 7.8951 (13.8); 7.8905 (8.8); 7.8828 (8.6); 7.7086 (4.5); 7.6871 (5.7); 7.6099 (1.4); 7.5926 (1.7); 7.5876 (1.9); 7.5620 (6.7); 7.5419 (10.4); 7.5217 (4.5); 7.3354 (1.4); 7.1419 (1.9); 7.1186 (1.5); 4.2575 (1.3); 4.2364 (1.7); 4.2203 (1.3); 4.0887 (1.6); 3.8133 (7.7); 3.5541 (9.2); 3.5127 (1.4); 3.4113 (2.2); 3.3672 (6.0); 3.3127 (3071.8); 3.2892 (66.0); 3.2581 (7.5); 3.2125 (2.2); 3.1757 (5.8); 3.1626 (6.1); 2.7009 (1.6); 2.6743 (7.0); 2.6700 (10.2); 2.6656 (7.9); 2.5995 (1.6); 2.5653 (2.4); 2.5232 (16.2); 2.5184 (27.4); 2.5100 (581.6); 2.5055 (1273.4); 2.5010 (1795.9); 2.4965 (1309.0); 2.4919 (630.4); 2.4379 (6.1); 2.4325 (5.1); 2.4073 (3.1); 2.3922 (2.7); 2.3518 (1.6); 2.3320 (8.0); 2.3279 (10.8); 2.3233 (7.8); 2.2795 (1.4); 2.2680 (1.7); 2.0730 (6.6); 0.0077 (3.3) I.1-093: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 12.6303 (1.0); 8.2012 (1.0); 8.1780 (1.1); 8.1230 (1.4); 8.0991 (1.2); 7.2096 (7.8); 7.1772 (1.5); 7.1585 (2.3); 7.1247 (3.5); 7.1063 (1.5); 4.7672 (2.4); 4.7291 (2.7); 4.3938 (1.0); 4.3727 (0.9); 4.3050 (0.5); 4.2252 (0.7); 4.2095 (1.0); 4.1892 (0.7); 4.0958 (1.7); 4.0562 (1.6); 3.6843 (1.5); 3.3181 (22.0); 2.6699 (0.7); 2.6273 (1.9); 2.6092 (4.5); 2.5904 (4.5); 2.5710 (2.0); 2.5395 (3.4); 2.5039 (105.7); 2.5005 (106.7); 2.3994 (1.7); 2.3775 (3.1); 2.3554 (2.2); 2.3213 (1.1); 2.2741 (1.2); 2.2475 (1.4); 2.2170 (0.8); 2.0651 (1.0); 2.0343 (1.3); 2.0102 (1.1); 1.8554 (1.0); 1.7756 (1.8); 1.3771 (0.6); 1.2714 (0.7); 1.2563 (1.0); 1.2385 (1.5); 1.1748 (1.3); 1.1561 (2.1); 1.1403 (6.2); 1.1217 (10.5); 1.1030 (5.2); 0.8480 (12.1); 0.8308 (16.0); 0.8139 (4.4); -0.0002 (1.3) I.1-094: 1 H-NMR (400.1 MHz, d 6 -DMSO): δ= 7.1497 (0.9); 7.1292 (5.7); 7.1211 (6.3); 7.1142 (1.7); 7.1099 (1.4); 7.1001 (1.1); 4.6731 (1.3); 4.6352 (1.4); 4.0500 (1.5); 4.0118 (1.3); 3.8004 (0.4); 3.7903 (0.5); 3.7782 (0.6); 3.7680 (0.5); 3.7581 (0.4); 3.5537 (1.0); 3.3067 (99.6); 3.2991 (22.8); 3.2827 (8.7); 3.1157 (16.0); 3.0904 (0.8); 3.0816 (0.8); 3.0472 (1.0); 3.0383 (1.0); 2.8596 (1.2); 2.7968 (1.1); 2.7738 (1.0); 2.7535 (0.9); 2.7306 (0.8); 2.6741 (0.5); 2.6696 (0.7); 2.6650 (0.6); 2.6594 (2.0); 2.5736 (0.7); 2.5230 (1.7); 2.5184 (2.4); 2.5096 (37.7); 2.5051 (83.8); 2.5006 (118.0); 2.4960 (87.2); 2.4916 (42.7); 2.4704 (0.8); 2.4488 (0.6); 2.4442 (0.6); 2.4260 (0.8); 2.4041 (0.7); 2.3841 (0.5); 2.3365 (0.3); 2.3319 (0.6); 2.3274 (0.9); 2.3229 (0.6); 2.2752 (12.0); 2.2631 (0.9); 2.2497 (0.8); 2.2381 (0.8); 2.2331 (0.4); 2.2081 (0.5); 2.1972 (0.6); 2.1764 (0.3); 2.1573 (0.5); 2.1452 (0.4); 2.1380 (0.3); 2.1325 (0.4); 2.1257 (0.6); 2.1012 (0.4); 1.7143 (0.5); 1.7036 (0.4); 1.6922 (0.6); 1.6825 (0.6); 1.6723 (0.4); 1.6596 (0.4); 0.0000 (1.0) I.1-095: 1 H-NMR (400.0 MHz, CDCl3): δ= 7.5205 (0.6); 7.3304 (3.0); 7.3275 (5.3); 7.3236 (2.3); 7.3144 (3.3); 7.3101 (14.1); 7.3066 (7.6); 7.2947 (4.5); 7.2913 (11.2); 7.2616 (106.7); 7.2527 (5.8); 7.2493 (3.7); 7.2398 (1.9); 7.2343 (6.8); 7.2282 (1.6); 7.2193 (1.2); 7.2160 (2.1); 7.2119 (1.2); 7.1788 (9.8); 7.1750 (12.6); 7.1580 (9.3); 7.1173 (1.0); 7.1073 (1.5); 7.1021 (1.3); 7.0926 (3.5); 7.0801 (2.3); 7.0768 (2.4); 7.0740 (2.7); 7.0672 (3.0); 7.0646 (2.9); 7.0595 (1.6); 7.0496 (3.7); 7.0450 (7.6); 7.0380 (9.4); 7.0350 (6.1); 7.0294 (10.4); 7.0193 (4.9); 7.0085 (0.8); 7.0021 (0.7); 6.9976 (0.6); 5.4089 (2.2); 4.8403 (4.6); 4.8368 (4.5); 4.8016 (5.2); 4.7980 (5.1); 4.2210 (6.7); 4.1822 (6.0); 3.9311 (1.1); 3.9200 (2.3); 3.9090 (2.8); 3.8985 (3.2); 3.8890 (2.8); 3.8781 (2.3); 3.8670 (1.1); 3.5569 (0.9); 3.5405 (2.8); 3.5231 (5.7); 3.5112 (6.2); 3.5083 (6.2); 3.4964 (5.7); 3.4911 (3.1); 3.4795 (2.8); 3.4626 (0.9); 2.8151 (8.1); 2.7978 (16.0); 2.7805 (7.4); 2.5736 (4.6); 2.5627 (4.6); 2.5376 (5.4); 2.5267 (5.2); 2.5042 (1.0); 2.4846 (1.3); 2.4811 (1.2); 2.4610 (3.5); 2.4416 (3.2); 2.4380 (3.0); 2.4187 (3.0); 2.4067 (3.4); 2.3920 (3.8); 2.3826 (4.6); 2.3681 (4.6); 2.3640 (1.7); 2.3492 (1.2); 2.3397 (2.0); 2.3253 (2.0); 2.2579 (1.7); 2.2389 (2.8); 2.2341 (1.6); 2.2253 (2.0); 2.2198 (1.7); 2.2149 (2.3); 2.2063 (3.1); 2.2013 (1.8); 2.1960 (1.2); 2.1871 (1.8); 2.1821 (2.4); 2.1631 (1.2); 2.1082 (5.8); 2.0858 (5.7); 2.0722 (5.1); 2.0498 (4.9); 1.8087 (1.5); 1.7974 (1.7); 1.7946 (1.9); 1.7838 (2.2); 1.7741 (2.1); 1.7709 (1.8); 1.7647 (1.7); 1.7614 (2.1); 1.7504 (1.8); 1.7411 (1.5); 1.7381 (1.3); 1.7265 (1.2); 1.6036 (6.9); 0.0079 (1.1); -0.0002 (33.8); -0.0085 (0.9) I.1-096: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.1263 (1.9); 7.1059 (7.1); 7.0921 (7.6); 7.0715 (1.9); 6.9333 (3.9); 6.9103 (1.7); 6.7949 (3.1); 6.7748 (2.3); 4.6540 (1.9); 4.6160 (2.2); 4.3312 (1.2); 4.3206 (3.2); 4.3099 (3.2); 4.2999 (1.4); 4.0953 (2.9); 4.0839 (4.4); 4.0725 (2.3); 4.0428 (2.2); 4.0046 (1.9); 3.7191 (0.6); 3.7086 (1.0); 3.6982 (1.1); 3.6877 (1.0); 3.6772 (0.7); 3.3256 (163.1); 2.7850 (1.3); 2.7750 (1.3); 2.7453 (1.7); 2.7354 (1.6); 2.6703 (0.6); 2.5099 (34.5); 2.5056 (71.2); 2.5012 (96.6); 2.4967 (68.4); 2.4924 (31.6); 2.4628 (1.9); 2.4407 (1.7); 2.4233 (1.8); 2.4011 (1.8); 2.3819 (1.1); 2.3638 (0.9); 2.3583 (0.8); 2.3402 (0.8); 2.3279 (0.6); 2.2630 (15.3); 2.2426 (1.2); 2.2288 (1.2); 2.2117 (0.6); 2.1905 (15.6); 2.1248 (0.7); 2.1121 (0.6); 2.1001 (0.6); 2.0940 (0.8); 2.0737 (0.8); 2.0685 (0.8); 2.0560 (16.0); 1.7078 (0.6); 1.6962 (0.8); 1.6853 (0.7); 1.6756 (0.7); 1.6641 (0.7); -0.0002 (6.5) I.1-097: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.2750 (2.0); 8.2700 (2.5); 7.6771 (1.2); 7.6708 (1.4); 7.6565 (1.6); 7.6502 (1.8); 7.5218 (0.7); 7.5013 (0.6); 7.4833 (2.4); 7.4628 (2.0); 7.3544 (0.7); 7.3334 (0.8); 7.3127 (0.5); 7.1858 (0.7); 7.1728 (0.8); 7.1560 (0.5); 7.0954 (0.7); 7.0792 (0.9); 4.7492 (1.0); 4.7097 (1.2); 4.5538 (1.6); 4.5216 (0.6); 4.4838 (2.3); 4.4599 (2.4); 4.4220 (0.7); 4.2795 (1.2); 4.2402 (1.1); 3.8949 (0.6); 3.8855 (0.7); 3.8733 (0.6); 3.8641 (0.6); 3.5216 (4.3); 3.1666 (0.6); 2.8917 (16.0); 2.8742 (0.8); 2.8433 (1.0); 2.8333 (1.0); 2.7526 (3.9); 2.6704 (0.6); 2.5962 (1.0); 2.5741 (1.0); 2.5552 (0.8); 2.5329 (0.8); 2.5238 (1.3); 2.5192 (1.9); 2.5105 (33.8); 2.5059 (74.9); 2.5013 (105.5); 2.4967 (74.0); 2.4921 (33.0); 2.4549 (0.5); 2.4312 (0.8); 2.4139 (0.7); 2.3281 (0.7); 2.3236 (0.6); 2.2685 (0.5); 2.2555 (0.9); 2.2437 (0.9); 2.2162 (1.4); 2.2074 (1.0); 2.1996 (0.9); 2.1813 (0.9); 1.7027 (0.6); 0.0080 (1.3); -0.0002 (48.4); -0.0085 (1.4) I.1-098: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.2967 (0.6); 8.2773 (0.6); 7.1459 (0.6); 7.1252 (3.8); 7.1179 (3.5); 7.1133 (1.3); 7.0967 (0.6); 4.6628 (0.8); 4.6247 (0.8); 4.0256 (0.8); 3.9880 (0.6); 3.5388 (0.8); 2.5351 (0.5); 2.5107 (4.7); 2.5061 (10.3); 2.5015 (14.4); 2.4969 (10.1); 2.4923 (4.9); 2.4796 (0.5); 2.4719 (0.8); 2.4522 (0.7); 2.2762 (6.9); 2.0270 (16.0) I.1-099: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.9665 (0.6); 7.9501 (0.6); 7.3617 (0.6); 7.3579 (0.7); 7.3359 (0.7); 7.3317 (0.6); 7.1908 (0.7); 7.1872 (0.7); 7.1781 (0.7); 7.1747 (0.7); 7.0763 (0.5); 7.0600 (0.8); 4.7313 (0.7); 4.6909 (0.8); 4.2301 (1.4); 4.1901 (1.2); 4.0786 (0.6); 4.0619 (0.7); 4.0456 (0.6); 3.7653 (0.6); 3.7550 (0.5); 3.5995 (1.3); 3.5639 (16.0); 3.5626 (15.0); 2.5196 (0.6); 2.5109 (9.7); 2.5064 (21.4); 2.5017 (29.9); 2.4971 (20.7); 2.4925 (9.2); 2.4816 (1.0); 2.4754 (0.7); 2.4707 (0.7); 2.4644 (1.2); 2.4478 (1.0); 2.4432 (1.3); 2.4361 (0.8); 2.4272 (1.8); 2.4104 (1.0); 2.3955 (1.2); 2.3923 (1.3); 2.3784 (1.3); 2.3749 (1.4); 2.3544 (1.0); 2.3406 (0.5); 2.3369 (0.9); 2.3316 (0.7); 2.2648 (0.8); 2.2541 (0.6); 2.1673 (0.6); 2.1502 (0.7); 2.1460 (0.7); 2.1326 (0.8); 2.1287 (0.7); 2.1153 (0.9); 2.1114 (1.0); 2.0938 (0.8); 2.0804 (0.5); 1.7412 (0.5); 1.7306 (0.6); 1.0617 (6.8); 1.0450 (6.7); -0.0002 (6.2) I.1-100: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.9170 (0.8); 7.1447 (1.4); 7.1243 (6.4); 7.1124 (7.1); 7.0916 (1.5); 4.6721 (1.7); 4.6341 (1.8); 4.0192 (1.8); 3.9813 (1.7); 3.7170 (0.6); 3.7060 (0.8); 3.6954 (0.9); 3.6855 (0.8); 3.6746 (0.7); 3.5626 (4.8); 2.9018 (0.5); 2.8848 (1.3); 2.8679 (1.4); 2.8524 (1.1); 2.8481 (1.0); 2.8331 (1.3); 2.8166 (1.2); 2.5204 (1.3); 2.5100 (9.1); 2.5054 (17.6); 2.5008 (24.4); 2.4962 (17.1); 2.4917 (7.9); 2.4869 (1.9); 2.4754 (1.4); 2.3460 (0.9); 2.3274 (0.9); 2.3232 (0.9); 2.3040 (0.7); 2.2756 (13.3); 2.2559 (1.0); 2.2457 (1.1); 2.2317 (1.0); 2.2038 (0.6); 2.1900 (0.5); 2.1466 (1.3); 2.1239 (1.3); 2.1123 (1.2); 2.0896 (1.1); 2.0461 (0.6); 2.0219 (0.6); 2.0145 (0.7); 1.9902 (0.6); 1.7078 (0.6); 1.6973 (0.6); 1.6865 (0.6); 1.6729 (0.7); 1.6555 (1.1); 1.6388 (1.3); 1.6220 (1.0); 1.6052 (0.5); 0.8248 (16.0); 0.8081 (15.4) I.1-101: 1 H-NMR (400.1 MHz, CDCl 3 ): δ= 7.3082 (0.4); 7.2935 (0.7); 7.2896 (0.9); 7.2866 (0.7); 7.2832 (0.3); 7.2743 (1.2); 7.2719 (1.1); 7.2701 (1.0); 7.2694 (1.0); 7.2652 (9.4); 7.2636 (9.2); 7.2612 (38.5); 7.2569 (1.0); 7.2560 (0.9); 7.2551 (0.9); 7.2535 (0.7); 7.2528 (0.7); 7.0240 (1.2); 7.0043 (1.1); 6.9972 (0.4); 6.9799 (0.4); 6.9760 (0.6); 6.9575 (2.0); 6.9546 (1.8); 6.9348 (1.5); 5.9943 (0.5); 4.7366 (1.3); 4.6981 (1.5); 4.2094 (1.4); 4.1709 (1.2); 4.0121 (0.5); 4.0037 (0.6); 4.0002 (0.4); 3.9920 (0.9); 3.9834 (0.5); 3.9801 (0.5); 3.9718 (0.5); 3.7384 (0.4); 3.7006 (16.0); 3.6478 (2.1); 3.5074 (0.3); 3.5032 (0.5); 3.4884 (1.2); 3.4736 (1.6); 3.4708 (1.4); 3.4579 (1.0); 3.4558 (1.2); 3.4410 (0.5); 2.5367 (0.4); 2.5336 (0.4); 2.5191 (2.0); 2.5146 (1.2); 2.5053 (3.1); 2.5032 (2.9); 2.4898 (3.0); 2.4699 (0.9); 2.4655 (1.2); 2.4537 (1.6); 2.4398 (0.7); 2.4302 (1.0); 2.4157 (0.9); 2.4118 (0.4); 2.3874 (0.6); 2.3730 (0.4); 2.2989 (0.4); 2.2797 (0.6); 2.2749 (0.4); 2.2663 (0.5); 2.2605 (0.4); 2.2556 (0.5); 2.2473 (0.7); 2.2422 (0.4); 2.2279 (0.4); 2.2231 (0.5); 2.1428 (1.1); 2.1222 (1.1); 2.1063 (1.0); 2.0857 (0.9); 2.0430 (1.1); 1.8157 (0.3); 1.8044 (0.4); 1.8014 (0.4); 1.7920 (0.5); 1.7828 (0.5); 1.7808 (0.5); 1.7777 (0.4); 1.7715 (0.4); 1.7687 (0.5); 1.7664 (0.4); 1.7595 (0.4); 1.7573 (0.4); 1.7481 (0.4); 1.5714 (7.4); 1.2763 (0.3); 1.2585 (0.8); 1.2406 (0.3); 0.0082 (0.5); 0.0040 (3.4); 0.0026 (3.5) I.1-102: 1 H-NMR (400.6 MHz, d6-DMSO): δ= 7.3795 (5.3); 7.3676 (1.7); 7.3605 (14.0); 7.3496 (2.0); 7.3425 (15.5); 7.3414 (16.0); 7.3348 (8.3); 7.3305 (13.4); 7.3259 (10.3); 7.3149 (3.2); 7.3097 (5.0); 7.3059 (3.3); 7.2841 (10.2); 7.2800 (14.6); 7.2018 (6.5); 7.1979 (10.2); 7.1839 (5.1); 7.1799 (7.9); 7.1763 (4.2); 5.6573 (2.8); 4.6623 (0.6); 4.6264 (9.3); 4.5875 (10.5); 4.1509 (10.5); 4.1119 (9.0); 3.7883 (1.7); 3.7772 (3.5); 3.7662 (4.5); 3.7574 (4.6); 3.7550 (4.7); 3.7463 (4.4); 3.7353 (3.5); 3.7244 (1.7); 3.1845 (0.8); 3.1677 (0.9); 2.7072 (0.5); 2.6761 (0.8); 2.6716 (1.1); 2.6670 (1.3); 2.6533 (6.7); 2.6425 (6.8); 2.6152 (8.2); 2.6044 (7.8); 2.5252 (4.0); 2.5205 (5.7); 2.5119 (47.2); 2.5074 (96.1); 2.5028 (130.0); 2.4982 (89.2); 2.4936 (39.4); 2.4240 (1.9); 2.4055 (2.5); 2.4002 (2.4); 2.3821 (5.4); 2.3638 (4.4); 2.3586 (4.0); 2.3406 (4.2); 2.3299 (1.1); 2.3253 (0.8); 2.3201 (0.8); 2.3023 (0.7); 2.2891 (4.0); 2.2752 (4.9); 2.2649 (6.0); 2.2510 (6.3); 2.2426 (8.1); 2.2338 (2.9); 2.2201 (8.2); 2.2096 (4.4); 2.2045 (6.8); 2.1820 (6.4); 2.1672 (2.5); 2.1485 (3.5); 2.1432 (2.3); 2.1357 (2.9); 2.1299 (2.5); 2.1240 (3.0); 2.1171 (4.0); 2.1116 (2.6); 2.1058 (1.8); 2.0981 (2.5); 2.0926 (2.9); 2.0859 (0.8); 2.0740 (2.0); 1.7250 (2.1); 1.7120 (3.0); 1.7010 (4.0); 1.6903 (3.3); 1.6802 (3.2); 1.6768 (2.6); 1.6691 (3.4); 1.6583 (2.2); 1.6447 (1.5); 0.0080 (1.3); -0.0002 (40.5); -0.0085 (1.2) I.1-103: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 7.9518 (0.5); 7.9324 (0.5); 7.1448 (1.3); 7.1245 (4.8); 7.1104 (4.2); 7.0898 (1.2); 4.6514 (0.9); 4.6133 (1.0); 4.0834 (0.6); 4.0658 (0.7); 4.0476 (0.6); 4.0150 (1.0); 3.9773 (0.9); 3.7087 (1.1); 3.7025 (1.1); 3.6979 (1.2); 3.6890 (1.2); 3.6788 (1.0); 3.6717 (0.8); 3.6606 (0.6); 3.5587 (16.0); 2.5104 (6.4); 2.5058 (14.0); 2.5012 (19.6); 2.4966 (13.6); 2.4920 (6.0); 2.4826 (0.5); 2.4651 (0.6); 2.4604 (0.9); 2.4575 (0.7); 2.4448 (1.5); 2.4371 (0.6); 2.4270 (1.5); 2.4230 (1.6); 2.4116 (0.7); 2.4057 (1.0); 2.3974 (1.1); 2.3934 (1.0); 2.3804 (1.2); 2.3763 (1.1); 2.3594 (0.7); 2.3558 (0.5); 2.3422 (0.8); 2.3390 (0.6); 2.3165 (0.6); 2.2756 (10.3); 2.2476 (0.6); 2.2387 (0.5); 2.2251 (0.6); 2.0862 (0.6); 2.0645 (1.0); 2.0517 (0.7); 2.0422 (0.6); 2.0304 (1.1); 2.0074 (0.8); 1.0636 (3.9); 1.0607 (4.6); 1.0468 (4.0); 1.0439 (4.5); -0.0002 (5.4) I.1-104: 1 H-NMR (400.1 MHz, CDCl 3 ): δ= 7.5231 (0.6); 7.5199 (0.6); 7.2643 (96.1); 7.2611 (98.2); 7.1288 (0.4); 7.1156 (0.9); 7.1039 (1.4); 7.0955 (1.2); 7.0877 (1.6); 7.0791 (1.8); 7.0607 (6.4); 7.0531 (6.2); 7.0415 (2.5); 7.0002 (0.5); 6.9972 (0.6); 4.9006 (2.7); 4.8619 (3.0); 4.7252 (0.9); 4.7167 (1.0); 4.6977 (1.8); 4.6892 (2.0); 4.6711 (1.0); 4.6622 (1.0); 4.2537 (3.3); 4.2144 (3.0); 3.9096 (0.5); 3.8986 (0.9); 3.8881 (1.4); 3.8769 (1.7); 3.8671 (1.6); 3.8576 (1.1); 3.8466 (0.6); 2.7503 (1.7); 2.7432 (1.8); 2.7407 (1.7); 2.7121 (2.1); 2.7048 (2.1); 2.6878 (0.4); 2.5606 (0.6); 2.5439 (0.8); 2.5186 (1.9); 2.4974 (1.7); 2.4771 (1.5); 2.4433 (1.1); 2.4280 (1.4); 2.4189 (1.6); 2.4037 (2.3); 2.3879 (2.5); 2.3852 (2.6); 2.3792 (1.4); 2.3642 (2.9); 2.3495 (1.8); 2.3468 (1.8); 2.3268 (1.6); 2.3240 (1.6); 2.3076 (0.6); 2.2900 (1.0); 2.2826 (0.7); 2.2738 (1.2); 2.2693 (1.0); 2.2657 (1.0); 2.2573 (1.4); 2.2496 (1.0); 2.2362 (1.0); 2.2335 (1.0); 2.2159 (0.5); 1.9461 (1.5); 1.9169 (1.6); 1.8478 (0.7); 1.8366 (1.2); 1.8243 (1.5); 1.8123 (2.0); 1.8040 (2.1); 1.7920 (2.4); 1.7792 (1.7); 1.6939 (3.0); 1.6616 (3.0); 1.5546 (28.1); 1.5526 (28.0); 1.5217 (0.5); 1.4822 (1.1); 1.4749 (1.1); 1.4678 (1.1); 1.3812 (0.9); 1.3515 (1.8); 1.3233 (1.1); 1.0874 (0.6); 1.0567 (1.5); 1.0302 (1.7); 1.0226 (1.4); 0.9976 (0.8); 0.9920 (0.7); 0.9810 (1.0); 0.9683 (0.6); 0.9510 (2.6); 0.9106 (14.7); 0.9022 (16.0); 0.8970 (15.2); 0.8944 (14.7); 0.8872 (12.8); 0.8848 (13.2); 0.8449 (1.4); 0.8152 (0.5); 0.7507 (12.5); 0.7333 (12.2); 0.0032 (42.7) I.1-105: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 12.3773 (1.5); 7.3837 (3.2); 7.3797 (3.5); 7.3633 (6.9); 7.3591 (7.6); 7.3531 (4.0); 7.3434 (4.9); 7.3372 (7.6); 7.3332 (6.5); 7.3171 (4.0); 7.3130 (3.9); 7.2100 (4.2); 7.2060 (4.4); 7.1973 (4.4); 7.1933 (5.3); 7.1901 (8.0); 7.1863 (8.4); 7.1773 (7.7); 7.1738 (8.5); 7.1698 (5.2); 7.1658 (5.1); 7.1570 (4.5); 7.1533 (4.8); 7.0952 (8.3); 7.0792 (11.0); 7.0598 (5.5); 4.7425 (12.4); 4.7031 (14.4); 4.2541 (16.0); 4.2145 (13.8); 3.7884 (2.7); 3.7780 (5.1); 3.7672 (7.1); 3.7579 (7.7); 3.7473 (6.9); 3.7367 (5.4); 3.7262 (2.2); 3.6385 (0.9); 3.3168 (89.6); 3.1651 (0.6); 2.7041 (12.6); 2.6939 (12.6); 2.6793 (1.6); 2.6747 (3.0); 2.6701 (4.8); 2.6644 (17.6); 2.6541 (15.4); 2.5618 (1.4); 2.5573 (1.7); 2.5528 (1.2); 2.5403 (1.6); 2.5236 (9.4); 2.5189 (14.8); 2.5102 (203.5); 2.5056 (437.7); 2.5010 (608.9); 2.4964 (428.8); 2.4919 (192.2); 2.4614 (2.0); 2.4563 (2.4); 2.4518 (2.2); 2.4469 (3.4); 2.4290 (4.0); 2.4192 (2.3); 2.4052 (10.4); 2.3986 (17.6); 2.3877 (7.9); 2.3805 (8.1); 2.3766 (17.3); 2.3650 (4.4); 2.3588 (13.7); 2.3498 (2.1); 2.3368 (14.3); 2.3279 (4.2); 2.3232 (2.8); 2.2887 (6.0); 2.2757 (6.7); 2.2642 (11.0); 2.2513 (10.8); 2.2363 (1.0); 2.2229 (9.2); 2.2199 (9.6); 2.2115 (6.8); 2.2059 (6.6); 2.1956 (5.9); 2.1900 (4.7); 2.1777 (7.1); 2.1712 (3.6); 2.1656 (2.7); 2.1584 (4.6); 2.1524 (4.1); 2.1340 (2.4); 2.0733 (1.0); 1.7823 (1.1); 1.7603 (3.1); 1.7547 (6.9); 1.7436 (7.0); 1.7307 (7.3); 1.7255 (4.2); 1.7198 (3.9); 1.7140 (4.9); 1.7008 (4.4); 1.6883 (2.8); 0.1461 (1.0); 0.0512 (0.6); 0.0080 (9.4); 0.0062 (3.6); -0.0002 (315.7); -0.0060 (4.4); -0.0069 (3.9); -0.0085 (9.8); - 0.0500 (1.2); -0.1495 (1.0) I.1-106: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.4043 (1.2); 7.1443 (1.7); 7.1240 (7.7); 7.1120 (8.4); 7.0913 (1.8); 4.6741 (2.0); 4.6359 (2.2); 3.9988 (2.2); 3.9607 (2.0); 3.8465 (1.8); 3.8401 (2.1); 3.8362 (2.2); 3.8326 (2.4); 3.8300 (2.4); 3.8266 (2.2); 3.8227 (2.1); 3.8163 (1.8); 3.7181 (0.7); 3.7071 (1.0); 3.6970 (1.1); 3.6871 (0.9); 3.6760 (0.7); 3.3125 (77.6); 3.2621 (0.6); 3.1680 (0.8); 3.1079 (1.6); 3.1016 (3.0); 3.0958 (1.4); 2.6694 (0.7); 2.5298 (1.6); 2.5228 (1.8); 2.5182 (3.7); 2.5095 (40.9); 2.5049 (87.8); 2.5003 (121.6); 2.4957 (86.2); 2.4912 (38.5); 2.4505 (0.6); 2.3737 (0.6); 2.3517 (1.2); 2.3318 (1.6); 2.3274 (1.5); 2.3093 (0.9); 2.2763 (16.0); 2.2649 (1.2); 2.2512 (1.2); 2.2402 (1.3); 2.2270 (1.3); 2.2093 (0.6); 2.1985 (0.7); 2.1853 (0.7); 2.1613 (1.7); 2.1392 (1.7); 2.1264 (1.5); 2.1042 (1.4); 2.0717 (0.9); 2.0514 (0.8); 2.0389 (0.6); 2.0272 (0.8); 2.0196 (1.0); 1.9956 (0.8); 1.6979 (0.6); 1.6869 (0.9); 1.6767 (0.7); 1.6645 (0.7); 1.6550 (0.7); 0.0080 (0.8); - 0.0002 (27.1); -0.0086 (0.8) I.1-107: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.4636 (0.6); 7.4548 (5.6); 7.4497 (1.8); 7.4378 (1.8); 7.4324 (6.3); 7.4238 (0.6); 7.1292 (2.0); 7.1086 (7.5); 7.0949 (8.0); 7.0744 (2.0); 6.9234 (0.7); 6.9147 (6.0); 6.9094 (1.9); 6.8976 (1.8); 6.8923 (5.7); 4.6476 (2.0); 4.6095 (2.3); 4.3213 (1.2); 4.3111 (3.2); 4.3015 (3.1); 4.2919 (1.6); 4.1467 (3.1); 4.1354 (4.5); 4.1244 (2.4); 4.0468 (2.3); 4.0085 (2.1); 3.7205 (0.7); 3.7102 (1.1); 3.6996 (1.2); 3.6895 (1.0); 3.6791 (0.8); 3.3486 (75.3); 2.7789 (1.3); 2.7688 (1.3); 2.7391 (1.7); 2.7290 (1.6); 2.5055 (56.9); 2.5011 (78.0); 2.4967 (56.5); 2.4758 (2.0); 2.4540 (1.8); 2.4360 (1.5); 2.4141 (1.7); 2.4048 (0.6); 2.3871 (1.2); 2.3691 (0.9); 2.3631 (0.9); 2.3455 (0.8); 2.2632 (16.0); 2.2471 (1.3); 2.2332 (1.2); 2.2053 (0.7); 2.1920 (0.7); 2.1307 (0.7); 2.1182 (0.6); 2.1123 (0.5); 2.1056 (0.6); 2.0995 (0.9); 2.0744 (0.6); 1.7090 (0.7); 1.6975 (0.8); 1.6869 (0.7); 1.6768 (0.7); 1.6654 (0.7); 1.6532 (0.5); -0.0002 (3.4) I.1-108: 1 H-NMR (400.1 MHz, d6-DMSO): δ= 19.7654 (0.7); 19.7059 (0.7); 17.6711 (0.8); 17.1313 (0.7); 14.0023 (0.7); 12.6881 (0.7); 11.6932 (0.8); 8.3710 (7.3); 8.3494 (7.0); 7.4486 (0.7); 7.3835 (2.1); 7.3638 (4.8); 7.3410 (4.7); 7.3190 (2.7); 7.2892 (0.8); 7.2104 (2.6); 7.1910 (5.5); 7.1789 (6.0); 7.1607 (5.7); 7.1546 (6.4); 7.1441 (8.4); 7.1390 (12.3); 7.1300 (12.0); 7.1250 (11.6); 7.1018 (15.0); 7.0957 (16.0); 7.0781 (12.2); 7.0590 (3.6); 6.6020 (0.7); 4.9535 (3.4); 4.9384 (4.4); 4.7582 (7.4); 4.7184 (8.7); 4.2744 (4.6); 4.2540 (5.1); 4.2354 (4.1); 4.2140 (4.2); 3.8711 (1.9); 3.8605 (2.8); 3.8499 (3.7); 3.8371 (3.8); 3.8264 (3.4); 3.8173 (3.0); 3.8057 (1.6); 3.5814 (0.7); 3.5223 (0.7); 3.4939 (0.8); 3.4290 (1.7); 3.3282 (392.0); 3.2339 (1.8); 3.2191 (1.6); 3.1935 (1.2); 3.1687 (10.9); 2.8908 (2.3); 2.7728 (1.8); 2.7438 (3.8); 2.7307 (7.0); 2.7181 (6.0); 2.7034 (6.3); 2.6704 (6.4); 2.6468 (1.5); 2.6102 (0.9); 2.5963 (1.2); 2.5828 (3.6); 2.5732 (5.3); 2.5653 (5.2); 2.5497 (7.2); 2.5408 (10.4); 2.5061 (759.5); 2.5017 (1025.9); 2.4973 (785.6); 2.4215 (3.1); 2.3994 (3.1); 2.3813 (3.8); 2.3736 (4.1); 2.3555 (4.9); 2.3290 (7.1); 2.3245 (5.5); 2.3106 (2.9); 2.2989 (3.8); 2.2867 (5.8); 2.2815 (5.9); 2.2704 (6.1); 2.2609 (6.3); 2.2476 (7.6); 2.2348 (5.5); 2.2263 (4.3); 2.2145 (4.0); 2.1923 (2.1); 2.1687 (2.4); 2.1575 (3.1); 2.1395 (3.1); 2.1243 (2.4); 2.1006 (1.8); 2.0718 (3.2); 2.0201 (0.7); 1.9080 (0.7); 1.8353 (8.2); 1.8253 (9.3); 1.8157 (9.2); 1.7441 (1.9); 1.7206 (3.0); 1.7063 (4.1); 1.6799 (3.3); 1.6650 (3.2); 1.6491 (3.1); 1.6271 (3.9); 1.6062 (2.9); 0.1451 (0.8); 0.0082 (5.3) I.1-109: 1 H-NMR (400.1 MHz, CDCl 3 ): δ= 7.2620 (55.2); 7.2122 (0.6); 7.1295 (0.4); 7.1162 (0.8); 7.1047 (1.5); 7.0951 (0.9); 7.0869 (1.6); 7.0803 (1.6); 7.0760 (1.1); 7.0621 (6.5); 7.0523 (6.0); 7.0443 (2.1); 7.0383 (1.7); 4.9128 (1.9); 4.9094 (2.0); 4.9008 (0.5); 4.8741 (2.2); 4.8705 (2.2); 4.8622 (0.6); 4.8585 (0.5); 4.7174 (1.0); 4.7065 (1.0); 4.6968 (0.5); 4.6902 (2.0); 4.6793 (2.0); 4.6630 (1.1); 4.6520 (1.0); 4.2507 (0.7); 4.2430 (3.0); 4.2042 (2.7); 3.8924 (0.5); 3.8821 (0.9); 3.8716 (1.3); 3.8612 (1.4); 3.8499 (1.2); 3.8395 (0.9); 3.8293 (0.5); 2.7500 (0.4); 2.7401 (0.5); 2.7321 (2.0); 2.7227 (2.0); 2.7117 (0.5); 2.7016 (0.6); 2.6944 (2.6); 2.6850 (2.5); 2.5609 (0.6); 2.5425 (0.7); 2.5367 (0.7); 2.5180 (1.8); 2.4996 (1.4); 2.4940 (1.4); 2.4757 (1.4); 2.4378 (1.2); 2.4237 (1.4); 2.4183 (0.6); 2.4132 (1.7); 2.4018 (3.3); 2.3845 (0.8); 2.3794 (2.9); 2.3702 (1.1); 2.3642 (2.4); 2.3564 (1.0); 2.3465 (0.6); 2.3416 (2.1); 2.3239 (0.4); 2.2938 (0.7); 2.2746 (1.2); 2.2696 (0.7); 2.2614 (0.9); 2.2557 (0.8); 2.2499 (0.9); 2.2421 (1.2); 2.2368 (0.9); 2.2311 (0.6); 2.2229 (0.7); 2.2173 (0.9); 2.1985 (0.5); 1.9647 (0.5); 1.9530 (1.1); 1.9456 (0.9); 1.9349 (0.7); 1.9301 (0.8); 1.9228 (1.2); 1.9005 (0.7); 1.8872 (0.8); 1.8759 (1.2); 1.8655 (0.9); 1.8538 (0.9); 1.8431 (1.1); 1.8324 (0.8); 1.8240 (0.6); 1.8182 (0.9); 1.8073 (1.0); 1.8005 (1.1); 1.7896 (1.4); 1.7831 (1.3); 1.7722 (1.0); 1.7653 (1.0); 1.7547 (0.4); 1.7484 (0.4); 1.6921 (2.3); 1.6850 (1.9); 1.6660 (2.3); 1.6597 (2.4); 1.6516 (1.6); 1.6446 (0.6); 1.5676 (16.8); 1.5181 (0.4); 1.5113 (0.4); 1.5033 (0.5); 1.4953 (0.6); 1.4896 (0.7); 1.4816 (0.8); 1.4737 (0.8); 1.4654 (0.9); 1.4572 (0.7); 1.4510 (0.6); 1.4438 (0.6); 1.4357 (0.5); 1.3961 (0.5); 1.3883 (0.8); 1.3810 (0.6); 1.3583 (1.4); 1.3384 (0.6); 1.3303 (1.0); 1.3228 (0.7); 1.0850 (0.6); 1.0596 (1.1); 1.0531 (1.3); 1.0284 (1.6); 1.0206 (1.2); 0.9958 (1.6); 0.9893 (0.6); 0.9785 (0.3); 0.9657 (2.4); 0.9488 (0.6); 0.9376 (2.2); 0.9101 (16.0); 0.8988 (15.3); 0.8938 (15.8); 0.8814 (14.5); 0.8607 (0.4); 0.8484 (1.1); 0.8441 (1.1); 0.8186 (0.4); 0.7478 (13.9); 0.7304 (13.5); 0.0082 (0.7); 0.0000 (23.9) I.1-111: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.9089 (0.8); 7.1441 (1.6); 7.1238 (6.1); 7.1098 (6.6); 7.0892 (1.6); 4.6676 (1.6); 4.6296 (1.8); 4.0134 (1.9); 3.9756 (1.6); 3.7175 (0.6); 3.7065 (0.8); 3.6961 (0.9); 3.6863 (0.8); 3.6753 (0.6); 3.4499 (16.0); 3.0047 (0.7); 2.9942 (0.8); 2.9870 (1.5); 2.9768 (1.5); 2.9727 (1.5); 2.9628 (1.4); 2.9551 (0.7); 2.9455 (0.7); 2.5231 (0.7); 2.5184 (1.0); 2.5098 (15.6); 2.5052 (33.6); 2.5006 (47.3); 2.4960 (32.7); 2.4915 (14.9); 2.4650 (1.4); 2.4539 (1.4); 2.3429 (0.9); 2.3233 (1.0); 2.3010 (0.8); 2.2756 (13.0); 2.2670 (1.2); 2.2529 (1.0); 2.2425 (1.1); 2.2287 (1.0); 2.2007 (0.6); 2.1870 (0.5); 2.1187 (1.4); 2.0962 (1.3); 2.0843 (1.2); 2.0618 (1.2); 2.0463 (0.6); 2.0222 (0.6); 2.0147 (0.8); 1.9905 (0.6); 1.6966 (0.7); 1.6865 (0.6); 1.6748 (0.5); 1.6646 (0.6); 1.4013 (1.5); 1.3832 (3.0); 1.3651 (3.3); 1.3471 (1.7); 0.8387 (5.4); 0.8203 (11.1); 0.8017 (4.7) I.1-112: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 10.8315 (1.3); 8.3271 (0.8); 8.3077 (1.5); 8.2885 (0.9); 7.5321 (0.9); 7.5210 (1.0); 7.5131 (1.0); 7.5019 (1.1); 7.3409 (0.9); 7.3286 (2.6); 7.3084 (3.1); 7.1670 (0.7); 7.1516 (0.8); 7.1346 (0.8); 7.1158 (2.7); 7.0659 (0.7); 7.0628 (0.7); 7.0482 (1.5); 7.0334 (1.2); 7.0303 (1.0); 7.0253 (0.8); 6.9860 (1.3); 6.9836 (1.4); 6.9666 (2.0); 6.9495 (1.6); 6.9326 (0.6); 6.9300 (0.6); 4.7106 (0.6); 4.6801 (0.8); 4.6716 (0.8); 4.6404 (0.8); 4.5032 (0.7); 4.4909 (0.7); 4.4827 (0.8); 4.4703 (0.7); 4.1974 (0.8); 4.1574 (0.7); 4.1352 (0.9); 4.0958 (0.8); 3.6900 (0.5); 3.6808 (0.7); 3.6703 (0.8); 3.6601 (0.8); 3.6508 (0.6); 3.4760 (16.0); 3.1850 (0.6); 3.1738 (0.6); 3.1679 (0.7); 3.1491 (0.9); 3.1384 (0.8); 3.0043 (1.1); 2.9815 (1.1); 2.9679 (0.8); 2.9455 (0.8); 2.6701 (0.6); 2.5341 (0.7); 2.5237 (1.5); 2.5189 (2.5); 2.5103 (33.0); 2.5057 (71.6); 2.5011 (99.7); 2.4965 (69.4); 2.4919 (31.1); 2.4730 (0.8); 2.3278 (0.6); 2.2630 (0.6); 2.2436 (0.9); 2.2244 (0.5); 2.2103 (0.7); 2.1970 (0.7); 2.1878 (1.3); 2.1754 (1.9); 2.1636 (1.4); 2.1518 (1.3); 2.1406 (0.6); 2.0727 (0.5); -0.0002 (5.4) I.1-113: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 16.6531 (1.0); 16.4917 (1.2); 10.8380 (7.6); 8.3084 (7.5); 8.2888 (7.4); 7.5218 (8.8); 7.5025 (9.6); 7.3612 (2.6); 7.3371 (5.5); 7.3285 (13.2); 7.3083 (15.1); 7.2952 (2.2); 7.1709 (3.0); 7.1473 (4.9); 7.1350 (5.2); 7.1264 (3.7); 7.1167 (16.0); 7.1112 (12.4); 7.0658 (5.2); 7.0456 (9.4); 7.0281 (6.7); 7.0010 (4.2); 6.9845 (6.2); 6.9696 (9.2); 6.9671 (10.0); 6.9498 (11.2); 6.9324 (5.1); 6.9301 (4.5); 4.6804 (6.9); 4.6414 (7.6); 4.5027 (2.9); 4.4907 (3.8); 4.4816 (4.3); 4.4703 (4.2); 4.4612 (3.1); 4.4480 (2.3); 4.1353 (7.8); 4.0954 (7.4); 3.6820 (3.4); 3.6711 (4.3); 3.6609 (4.4); 3.6489 (3.8); 3.6396 (3.4); 3.4468 (130.7); 3.4028 (10.7); 3.3984 (10.2); 3.3937 (10.1); 3.3891 (9.3); 3.3843 (7.9); 3.3794 (5.9); 3.3739 (4.2); 3.3683 (3.6); 3.3634 (3.4); 3.3583 (3.8); 3.3542 (3.6); 3.3498 (3.4); 3.3244 (4.1); 3.3127 (2.1); 3.3078 (1.2); 3.3004 (1.2); 3.2956 (2.7); 3.2906 (3.3); 3.2855 (2.8); 3.2799 (2.2); 3.2338 (2.1); 3.2291 (2.1); 3.2236 (2.1); 3.2187 (2.8); 3.2143 (4.8); 3.2076 (3.4); 3.1850 (4.2); 3.1722 (5.5); 3.1678 (7.6); 3.1475 (6.0); 3.1365 (5.6); 3.1015 (1.3); 3.0458 (1.3); 3.0411 (1.4); 3.0048 (5.7); 2.9815 (5.6); 2.9676 (5.3); 2.9456 (4.1); 2.6705 (3.7); 2.6655 (2.5); 2.6364 (1.1); 2.5478 (1.9); 2.5103 (226.6); 2.5058 (476.1); 2.5012 (643.3); 2.4966 (445.4); 2.4920 (197.1); 2.4729 (9.5); 2.4609 (5.4); 2.4563 (7.0); 2.4518 (7.8); 2.4470 (5.2); 2.4426 (2.8); 2.4060 (1.9); 2.3817 (1.7); 2.3280 (3.9); 2.3233 (3.0); 2.3039 (2.5); 2.2817 (3.4); 2.2621 (4.9); 2.2411 (5.5); 2.2188 (4.4); 2.2100 (6.2); 2.1877 (9.8); 2.1757 (9.4); 2.1639 (5.8); 2.1523 (8.2); 2.1326 (2.3); 2.1217 (3.2); 2.1100 (2.3); 2.0729 (2.2); 2.0162 (1.3); 1.9686 (1.5); 1.9483 (3.3); 1.9348 (2.8); 1.9243 (2.8); 1.9158 (4.2); 1.8909 (3.6); 1.8859 (2.2); 1.8811 (1.8); 1.8721 (2.0); 1.8575 (1.2); 1.8273 (1.2); 1.8158 (1.2); 1.7611 (2.1); 1.7379 (1.4); 1.7304 (1.3); 1.7086 (3.0); 1.7038 (3.0); 1.6981 (3.3); 1.6875 (1.9); 1.6635 (5.3); 1.6538 (2.8); 1.6417 (2.7); 1.6305 (2.2); 1.6066 (2.5); 1.6019 (2.6); 1.5973 (2.6); 1.4791 (1.1); -0.0002 (19.8) I.1-114: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 11.8093 (5.6); 7.5295 (2.0); 7.5212 (2.0); 7.5135 (3.2); 7.5050 (2.9); 7.5030 (3.0); 7.4960 (1.7); 7.4873 (2.2); 7.2311 (1.2); 7.2266 (1.1); 7.2153 (11.8); 7.2119 (6.5); 7.2060 (5.7); 7.1994 (7.2); 7.1964 (10.7); 7.1857 (0.6); 7.1800 (0.7); 7.0726 (2.1); 6.9448 (2.0); 4.7058 (3.8); 4.6662 (4.4); 4.2413 (4.7); 4.2012 (4.0); 3.9643 (4.0); 3.8630 (0.7); 3.8528 (1.5); 3.8422 (2.1); 3.8322 (2.4); 3.8220 (2.0); 3.8116 (1.5); 3.8020 (0.7); 3.3888 (70.2); 3.2101 (64.7); 3.1681 (16.0); 2.7502 (3.2); 2.7397 (3.2); 2.7120 (4.0); 2.7015 (3.8); 2.6788 (0.8); 2.6742 (1.6); 2.6695 (2.4); 2.6650 (1.6); 2.6602 (0.8); 2.5554 (0.5); 2.5507 (0.8); 2.5460 (0.8); 2.5398 (1.5); 2.5231 (6.2); 2.5183 (9.1); 2.5097 (130.5); 2.5052 (276.0); 2.5005 (376.9); 2.4959 (262.8); 2.4913 (118.3); 2.4408 (4.5); 2.4188 (4.7); 2.4022 (4.7); 2.3807 (5.7); 2.3597 (1.6); 2.3365 (0.9); 2.3319 (1.7); 2.3273 (2.3); 2.3227 (1.6); 2.3180 (0.8); 2.3083 (1.7); 2.2960 (2.0); 2.2842 (2.9); 2.2721 (2.8); 2.2553 (0.6); 2.2426 (1.9); 2.2319 (3.0); 2.2145 (2.2); 2.2028 (1.5); 2.1956 (1.2); 2.1904 (1.2); 2.1836 (2.3); 2.1715 (0.7); 2.1638 (1.3); 2.1593 (1.5); 2.1400 (0.6); 2.0719 (1.0); 1.7926 (0.8); 1.7841 (1.7); 1.7728 (1.6); 1.7622 (1.8); 1.7544 (1.9); 1.7423 (1.4); 1.7295 (1.2); 1.7181 (0.8); 0.0120 (0.6); 0.0080 (1.3); -0.0002 (46.8); -0.0085 (1.3) I.1-115: 1 H-NMR (400.1 MHz, d6-DMSO): δ= 12.3254 (1.7); 7.2129 (1.0); 7.2059 (1.9); 7.1962 (12.0); 7.1791 (12.6); 7.1742 (12.5); 7.1639 (3.2); 7.1573 (11.6); 7.1476 (2.0); 7.1404 (1.0); 4.5857 (8.6); 4.5461 (10.4); 4.2417 (0.3); 4.1978 (11.6); 4.1583 (9.7); 3.9660 (0.8); 3.8065 (1.9); 3.7955 (3.4); 3.7847 (5.0); 3.7753 (5.5); 3.7649 (5.0); 3.7544 (3.9); 3.7433 (1.8); 3.5809 (0.4); 3.5573 (0.5); 3.3351 (12.0); 3.1710 (16.0); 2.6799 (8.9); 2.6695 (9.2); 2.6399 (11.2); 2.6295 (10.9); 2.5248 (0.8); 2.5201 (1.2); 2.5114 (25.4); 2.5068 (56.9); 2.5022 (80.2); 2.4976 (57.3); 2.4930 (26.5); 2.4431 (2.2); 2.4260 (2.7); 2.4174 (2.3); 2.4018 (6.5); 2.3845 (5.3); 2.3778 (5.2); 2.3714 (12.2); 2.3625 (4.5); 2.3496 (11.3); 2.3315 (9.8); 2.3254 (5.4); 2.3098 (12.1); 2.3011 (7.8); 2.2871 (7.6); 2.2706 (0.9); 2.2597 (4.4); 2.2474 (7.5); 2.2323 (3.4); 2.2301 (4.0); 2.2230 (1.5); 2.2189 (3.8); 2.2134 (3.0); 2.2086 (2.1); 2.2057 (2.5); 2.2015 (4.4); 2.1947 (2.8); 2.1893 (1.9); 2.1820 (3.1); 2.1754 (2.8); 2.1577 (1.7); 1.7551 (2.2); 1.7447 (4.1); 1.7332 (4.5); 1.7267 (2.9); 1.7223 (3.7); 1.7154 (4.8); 1.7084 (2.8); 1.7022 (4.3); 1.6907 (2.9); 1.6769 (1.9); 0.0082 (0.5); 0.0000 (16.4) I.1-116: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.1474 (1.7); 7.1294 (2.0); 7.1162 (6.1); 7.1099 (8.8); 7.0968 (11.4); 7.0768 (1.8); 6.8372 (5.8); 6.8156 (4.9); 4.6496 (2.1); 4.6111 (2.2); 4.3323 (0.5); 4.3134 (1.3); 4.3022 (3.4); 4.2907 (3.8); 4.2803 (1.4); 4.1070 (3.1); 4.0961 (5.0); 4.0844 (2.4); 4.0504 (2.4); 4.0124 (2.0); 3.7272 (0.7); 3.7168 (1.1); 3.7061 (1.2); 3.6952 (1.1); 3.6844 (0.7); 3.3485 (2.7); 3.3230 (697.4); 3.2993 (40.8); 3.2006 (0.8); 3.1749 (0.5); 2.7825 (1.3); 2.7724 (1.4); 2.7426 (1.7); 2.7324 (1.8); 2.6703 (1.4); 2.5566 (1.4); 2.5376 (4.8); 2.5100 (89.9); 2.5057 (185.1); 2.5012 (250.3); 2.4968 (175.9); 2.4755 (2.2); 2.4535 (2.0); 2.4353 (1.9); 2.4140 (2.0); 2.3891 (1.4); 2.3718 (1.1); 2.3482 (1.0); 2.3280 (1.6); 2.2817 (1.3); 2.2633 (16.0); 2.2460 (1.3); 2.2318 (1.3); 2.2146 (0.5); 2.2041 (0.8); 2.1906 (0.8); 2.1522 (0.6); 2.1325 (0.7); 2.1206 (0.7); 2.1023 (1.0); 2.0732 (0.8); 1.7145 (0.7); 1.7035 (0.8); 1.6922 (0.8); 1.6714 (0.8); 1.6600 (0.5); 1.1683 (0.8); 1.1563 (6.1); 1.1373 (13.1); 1.1183 (5.9); -0.0002 (13.3) I.1-117: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 7.3045 (2.6); 7.2993 (1.0); 7.2858 (4.0); 7.2829 (3.9); 7.2644 (3.3); 7.1313 (1.9); 7.1106 (7.7); 7.0983 (8.2); 7.0777 (1.8); 6.9612 (1.5); 6.9429 (2.7); 6.9279 (4.8); 6.9085 (4.1); 4.6502 (2.0); 4.6120 (2.2); 4.3313 (1.3); 4.3203 (3.7); 4.3089 (4.0); 4.2986 (1.5); 4.1439 (3.3); 4.1326 (5.3); 4.1211 (2.4); 4.0531 (2.3); 4.0150 (2.0); 3.7295 (0.7); 3.7186 (1.1); 3.7083 (1.2); 3.6983 (1.1); 3.6875 (0.7); 3.3626 (76.8); 2.7840 (1.3); 2.7738 (1.4); 2.7443 (1.8); 2.7340 (1.7); 2.5234 (1.1); 2.5100 (25.0); 2.5056 (52.1); 2.5011 (71.0); 2.4967 (50.4); 2.4923 (23.2); 2.4805 (2.2); 2.4587 (1.8); 2.4407 (1.5); 2.4330 (0.6); 2.4189 (1.7); 2.4072 (0.8); 2.3908 (1.2); 2.3728 (0.9); 2.3669 (0.8); 2.3493 (0.8); 2.2632 (16.0); 2.2475 (1.3); 2.2337 (1.2); 2.2056 (0.8); 2.1925 (0.8); 2.1371 (0.7); 2.1243 (0.6); 2.1188 (0.5); 2.1124 (0.6); 2.1056 (0.9); 2.0863 (0.5); 2.0810 (0.6); 1.7191 (0.7); 1.7073 (0.9); 1.6964 (0.7); 1.6871 (0.7); 1.6754 (0.8); 1.6635 (0.5) I.1-118: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.3718 (1.6); 7.3679 (1.7); 7.3514 (3.5); 7.3476 (3.8); 7.3415 (2.0); 7.3316 (2.4); 7.3257 (3.9); 7.3050 (2.0); 7.3016 (1.9); 7.2046 (2.2); 7.2008 (2.3); 7.1919 (2.3); 7.1848 (4.1); 7.1810 (4.3); 7.1721 (4.0); 7.1685 (4.3); 7.1645 (2.6); 7.1605 (2.5); 7.1516 (2.2); 7.1482 (2.3); 7.0849 (4.2); 7.0690 (5.7); 7.0496 (2.8); 4.7002 (6.5); 4.6608 (7.8); 4.2973 (8.4); 4.2575 (7.0); 3.9112 (1.3); 3.8999 (2.5); 3.8912 (3.3); 3.8802 (4.7); 3.8711 (2.9); 3.8606 (2.5); 3.8492 (1.1); 3.4027 (98.0); 3.3419 (2.7); 3.3248 (4.7); 3.3164 (3.7); 3.3078 (3.4); 3.2998 (6.0); 3.2827 (3.4); 3.2515 (1.1); 3.2345 (2.0); 3.2221 (4.4); 3.2047 (13.6); 3.1875 (16.0); 3.1778 (3.8); 3.1703 (7.4); 3.1613 (5.2); 3.1444 (2.8); 2.6709 (5.0); 2.6594 (4.5); 2.6309 (5.8); 2.6190 (5.5); 2.5234 (3.1); 2.5187 (4.6); 2.5101 (70.3); 2.5055 (151.7); 2.5009 (210.5); 2.4963 (146.2); 2.4917 (65.3); 2.4619 (2.2); 2.4441 (2.5); 2.4354 (1.9); 2.4204 (5.1); 2.4040 (8.7); 2.3975 (4.0); 2.3841 (7.5); 2.3642 (4.8); 2.3438 (4.6); 2.3323 (1.0); 2.3277 (1.4); 2.3231 (1.0); 2.2797 (3.1); 2.2669 (3.4); 2.2555 (5.3); 2.2426 (5.3); 2.2269 (0.7); 2.2142 (4.1); 2.2071 (6.0); 2.1924 (3.2); 2.1811 (2.8); 2.1753 (2.3); 2.1629 (4.0); 2.1571 (1.9); 2.1511 (1.3); 2.1438 (2.3); 2.1385 (2.4); 2.1193 (1.2); 2.0717 (0.9); 1.8589 (0.6); 1.8458 (1.3); 1.8289 (3.7); 1.8174 (4.6); 1.8111 (5.8); 1.8009 (6.6); 1.7936 (4.8); 1.7848 (5.2); 1.7766 (2.6); 1.7690 (2.6); 1.7617 (1.4); 1.7479 (2.8); 1.7383 (2.7); 1.7319 (5.9); 1.7209 (8.6); 1.7177 (7.8); 1.7097 (5.3); 1.7003 (8.8); 1.6915 (4.0); 1.6861 (5.8); 1.6796 (3.4); 1.6677 (3.1); 1.6548 (2.0); -0.0002 (1.6) I.1-119: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 7.1315 (1.8); 7.1110 (7.6); 7.0986 (8.1); 7.0865 (4.2); 7.0655 (4.5); 6.8231 (0.8); 6.8158 (5.6); 6.7945 (4.7); 4.6509 (2.0); 4.6127 (2.2); 4.3104 (1.2); 4.2996 (3.4); 4.2883 (3.6); 4.2781 (1.4); 4.0993 (3.1); 4.0881 (4.9); 4.0765 (2.4); 4.0507 (2.3); 4.0125 (2.0); 3.7260 (0.7); 3.7156 (1.0); 3.7052 (1.2); 3.6949 (1.1); 3.6847 (0.8); 3.5245 (4.6); 2.7822 (1.3); 2.7720 (1.3); 2.7424 (1.7); 2.7323 (1.6); 2.5101 (9.4); 2.5059 (19.2); 2.5015 (25.7); 2.4971 (18.2); 2.4759 (1.8); 2.4541 (1.7); 2.4361 (1.5); 2.4143 (1.8); 2.4077 (0.6); 2.3898 (1.1); 2.3718 (0.9); 2.3660 (0.8); 2.3482 (0.8); 2.2648 (15.6); 2.2463 (1.3); 2.2245 (16.0); 2.2046 (0.8); 2.1913 (0.8); 2.1336 (0.7); 2.1208 (0.6); 2.1150 (0.5); 2.1086 (0.6); 2.1024 (0.9); 2.0965 (0.5); 2.0829 (0.5); 2.0774 (0.6); 1.7149 (0.6); 1.7030 (0.8); 1.6919 (0.7); 1.6830 (0.7); 1.6711 (0.7); - 0.0002 (0.6) I.1-120: 1 H-NMR (400.1 MHz, d6-DMSO): δ= 11.7028 (3.9); 7.3857 (0.5); 7.3819 (0.6); 7.3615 (1.4); 7.3394 (1.4); 7.3190 (0.7); 7.3154 (0.7); 7.2125 (0.6); 7.2092 (0.7); 7.1926 (1.4); 7.1892 (1.5); 7.1770 (1.5); 7.1690 (0.9); 7.1595 (0.8); 7.1564 (0.8); 7.0754 (1.4); 7.0590 (2.0); 7.0403 (1.0); 4.7263 (2.3); 4.6864 (2.7); 4.2446 (2.8); 4.2045 (2.4); 3.8459 (0.4); 3.8360 (0.9); 3.8252 (1.3); 3.8151 (1.5); 3.8046 (1.3); 3.7948 (1.0); 3.7849 (0.5); 3.3584 (3.1); 3.3400 (10.5); 3.3219 (14.3); 3.3036 (4.2); 3.1691 (10.1); 2.7798 (1.8); 2.7697 (1.8); 2.7415 (2.2); 2.7313 (2.2); 2.5231 (0.4); 2.5098 (14.4); 2.5054 (31.9); 2.5009 (45.4); 2.4964 (33.9); 2.4919 (16.8); 2.4584 (2.4); 2.4364 (2.4); 2.4203 (2.4); 2.3983 (3.2); 2.3797 (1.5); 2.3584 (1.1); 2.3278 (0.3); 2.3045 (1.0); 2.2919 (1.2); 2.2802 (1.6); 2.2677 (1.6); 2.2511 (0.4); 2.2385 (1.0); 2.2276 (1.2); 2.2229 (1.0); 2.2046 (1.2); 2.1928 (0.8); 2.1857 (0.7); 2.1805 (0.8); 2.1736 (1.3); 2.1616 (0.5); 2.1539 (0.8); 2.1495 (0.9); 2.1299 (0.4); 1.7782 (0.5); 1.7684 (1.0); 1.7570 (1.0); 1.7463 (1.1); 1.7383 (1.2); 1.7259 (0.9); 1.7143 (0.7); 1.7023 (0.4); 1.2086 (7.2); 1.1903 (16.0); 1.1719 (7.1); 0.0083 (0.3) I.1-121: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 12.5493 (1.1); 8.2765 (1.5); 8.2561 (1.6); 7.1739 (2.6); 7.1532 (7.5); 7.1340 (6.9); 7.1133 (2.1); 4.6775 (1.7); 4.6395 (1.9); 4.2451 (0.6); 4.2300 (0.8); 4.2106 (0.9); 4.0522 (1.8); 4.0139 (1.8); 3.7059 (1.1); 3.6965 (0.9); 3.6864 (0.7); 3.3642 (0.7); 3.3248 (153.5); 3.2909 (1.5); 3.1858 (1.3); 3.1672 (2.3); 2.8282 (0.6); 2.7570 (1.3); 2.6744 (2.9); 2.6697 (4.0); 2.6652 (2.9); 2.6057 (1.6); 2.5869 (4.0); 2.5680 (4.3); 2.5490 (1.5); 2.5231 (9.7); 2.5185 (15.2); 2.5098 (232.1); 2.5052 (507.3); 2.5006 (711.3); 2.4960 (503.2); 2.4915 (227.5); 2.4716 (5.0); 2.4670 (5.4); 2.4624 (4.1); 2.3708 (0.9); 2.3495 (1.3); 2.3320 (3.8); 2.3275 (5.2); 2.3229 (3.5); 2.3067 (1.1); 2.2713 (1.0); 2.2568 (1.1); 2.2464 (1.2); 2.2280 (1.9); 2.2053 (1.8); 2.1938 (1.5); 2.1716 (1.2); 2.0733 (1.1); 2.0078 (0.8); 1.9830 (0.7); 1.7128 (0.8); 1.6020 (0.8); 1.5881 (0.7); 1.5121 (1.2); 1.5000 (1.6); 1.4868 (1.8); 1.4655 (1.0); 1.1933 (0.9); 1.1841 (7.1); 1.1753 (1.9); 1.1652 (16.0); 1.1462 (6.9); 1.0966 (0.6); 1.0782 (1.0); 1.0601 (0.5); 0.9820 (0.6); 0.8917 (8.1); 0.8753 (7.9); 0.8255 (8.0); 0.8093 (7.7); 0.1462 (1.0); 0.0080 (9.7); -0.0002 (346.4); -0.0086 (10.6); -0.0338 (2.0); -0.1494 (1.2) I.1-122: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 7.3683 (0.6); 7.3479 (1.4); 7.3258 (1.4); 7.3056 (0.6); 7.2030 (0.8); 7.1872 (1.5); 7.1832 (1.5); 7.1708 (1.6); 7.1626 (1.0); 7.1503 (0.9); 7.0857 (1.6); 7.0696 (2.1); 7.0501 (1.0); 4.7345 (2.2); 4.6951 (2.5); 4.6192 (0.6); 4.2853 (2.8); 4.2456 (2.4); 3.9014 (0.8); 3.8920 (1.2); 3.8815 (1.6); 3.8720 (1.2); 3.8615 (0.9); 3.3604 (1.6); 3.3239 (383.6); 3.2732 (0.9); 3.2547 (0.6); 3.2178 (4.1); 3.2098 (3.5); 3.2035 (3.9); 3.1999 (4.0); 3.1922 (3.5); 3.1784 (1.6); 3.1682 (1.7); 3.1587 (0.6); 2.7281 (1.8); 2.7166 (1.8); 2.6989 (2.8); 2.6881 (2.5); 2.6742 (3.8); 2.6694 (4.3); 2.6648 (3.0); 2.6603 (1.3); 2.5368 (1.7); 2.5229 (10.8); 2.5182 (16.4); 2.5095 (227.4); 2.5050 (496.0); 2.5003 (692.8); 2.4957 (481.1); 2.4911 (214.4); 2.4666 (2.4); 2.4506 (3.4); 2.4299 (2.8); 2.4254 (1.8); 2.4105 (2.4); 2.3898 (2.6); 2.3364 (1.5); 2.3318 (3.1); 2.3271 (4.3); 2.3225 (3.0); 2.3178 (1.4); 2.2761 (1.2); 2.2633 (1.2); 2.2517 (2.0); 2.2390 (1.8); 2.2106 (1.5); 2.2040 (2.1); 2.1897 (1.2); 2.1780 (1.0); 2.1723 (0.9); 2.1597 (1.4); 2.1401 (0.8); 2.1351 (0.9); 2.0722 (1.1); 1.6868 (1.2); 1.6756 (1.2); 1.6644 (1.0); 1.6460 (0.9); 1.6328 (0.8); 1.6204 (0.5); 1.1575 (0.8); 1.0315 (6.0); 1.0138 (14.6); 0.9960 (6.0); 0.9754 (7.1); 0.9577 (16.0); 0.9400 (6.9); 0.8308 (0.5); 0.0080 (5.1); -0.0002 (202.4); -0.0085 (6.1); -0.1497 (0.7) I.1-123: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.3884 (4.8); 7.3795 (0.7); 7.3690 (14.0); 7.3502 (16.0); 7.3445 (8.1); 7.3401 (14.3); 7.3356 (10.6); 7.3245 (2.9); 7.3195 (4.9); 7.3157 (3.1); 7.2916 (10.7); 7.2875 (15.5); 7.2014 (6.8); 7.1976 (12.0); 7.1943 (12.2); 7.1838 (5.6); 7.1798 (8.5); 7.0624 (13.2); 6.9306 (6.7); 4.6605 (0.5); 4.6209 (10.1); 4.5816 (11.3); 4.1542 (11.4); 4.1281 (1.0); 4.1150 (10.0); 3.8273 (2.4); 3.8168 (4.3); 3.8062 (5.6); 3.7952 (6.2); 3.7854 (5.8); 3.7750 (4.8); 3.7646 (3.1); 3.7503 (1.7); 3.7394 (1.7); 3.7280 (1.7); 3.7191 (1.7); 3.7084 (1.7); 3.5969 (1.8); 3.1681 (1.1); 2.8244 (5.8); 2.8141 (6.1); 2.7849 (7.3); 2.7747 (7.2); 2.6746 (0.8); 2.6700 (1.1); 2.6651 (1.1); 2.5235 (0.7); 2.5187 (1.9); 2.5101 (61.4); 2.5055 (134.0); 2.5009 (188.0); 2.4963 (138.2); 2.4918 (67.5); 2.4570 (9.2); 2.4481 (3.3); 2.4345 (7.3); 2.4237 (3.7); 2.4176 (6.6); 2.4056 (6.2); 2.3952 (6.9); 2.3872 (5.9); 2.3827 (5.2); 2.3639 (4.5); 2.3411 (0.9); 2.3372 (0.8); 2.3323 (1.2); 2.3277 (1.5); 2.3230 (1.4); 2.3159 (4.1); 2.3024 (4.9); 2.2916 (6.1); 2.2783 (6.3); 2.2610 (2.2); 2.2496 (3.6); 2.2368 (3.7); 2.2035 (2.4); 2.1845 (3.8); 2.1795 (2.3); 2.1720 (3.1); 2.1656 (2.8); 2.1601 (3.3); 2.1531 (4.5); 2.1479 (3.0); 2.1414 (2.1); 2.1336 (2.8); 2.1286 (3.3); 2.1167 (0.7); 2.1094 (1.6); 2.0720 (0.7); 1.7414 (1.8); 1.7293 (3.0); 1.7180 (4.0); 1.7075 (3.6); 1.6974 (3.7); 1.6862 (3.8); 1.6751 (2.5); 1.6621 (1.7); 1.1797 (0.7); -0.0002 (5.8) I.1-124: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.1459 (1.6); 7.1259 (4.8); 7.1077 (5.4); 7.1023 (1.1); 7.0871 (1.6); 4.6490 (1.4); 4.6108 (1.6); 4.0551 (1.6); 4.0387 (1.3); 4.0209 (4.3); 4.0039 (4.3); 3.9860 (1.4); 3.7248 (0.6); 3.7143 (0.8); 3.7042 (0.9); 3.6939 (0.8); 3.6834 (0.6); 3.3154 (45.4); 3.1852 (2.3); 2.7296 (1.2); 2.7194 (1.2); 2.6900 (1.6); 2.6797 (1.6); 2.5233 (1.3); 2.5186 (1.8); 2.5100 (22.8); 2.5054 (49.3); 2.5007 (68.3); 2.4961 (47.2); 2.4915 (20.7); 2.4263 (1.8); 2.4045 (1.7); 2.3940 (0.9); 2.3867 (1.4); 2.3751 (0.7); 2.3699 (0.7); 2.3649 (1.4); 2.3520 (0.6); 2.2875 (0.9); 2.2760 (11.4); 2.2631 (1.2); 2.2493 (1.0); 2.2212 (0.6); 2.2078 (0.6); 2.1496 (0.5); 2.1194 (0.6); 1.6969 (0.7); 1.6763 (0.5); 1.6649 (0.6); 1.1525 (7.1); 1.1347 (16.0); 1.1169 (7.0); -0.0002 (2.4) I.1-125: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 7.5747 (4.1); 7.5683 (4.3); 7.3791 (2.0); 7.3727 (1.8); 7.3569 (2.5); 7.3504 (2.4); 7.1933 (4.2); 7.1711 (3.2); 7.1252 (2.0); 7.1047 (7.4); 7.0904 (7.9); 7.0699 (2.0); 4.6527 (2.0); 4.6146 (2.3); 4.3580 (1.1); 4.3477 (2.9); 4.3382 (3.2); 4.3291 (1.7); 4.2560 (3.3); 4.2452 (3.8); 4.2342 (1.8); 4.0414 (2.3); 4.0033 (2.0); 3.7206 (0.7); 3.7099 (1.0); 3.6993 (1.2); 3.6890 (1.0); 3.6787 (0.7); 3.3295 (328.1); 3.2978 (0.6); 3.1673 (0.5); 2.7824 (1.3); 2.7724 (1.3); 2.7427 (1.7); 2.7327 (1.6); 2.6703 (0.8); 2.5099 (51.5); 2.5056 (105.7); 2.5012 (142.7); 2.4968 (101.0); 2.4926 (46.9); 2.4634 (2.0); 2.4412 (1.8); 2.4236 (1.8); 2.4017 (1.8); 2.3805 (1.2); 2.3628 (1.0); 2.3388 (1.0); 2.3328 (0.8); 2.3284 (0.9); 2.2613 (16.0); 2.2417 (1.3); 2.2279 (1.2); 2.1998 (0.7); 2.1866 (0.8); 2.1284 (0.8); 2.1158 (0.6); 2.1040 (0.6); 2.0975 (0.9); 2.0729 (0.9); 1.7164 (0.6); 1.7040 (0.8); 1.6929 (0.8); 1.6840 (0.7); 1.6721 (0.7); 1.6610 (0.5); -0.0002 (1.4) I.1-126: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.2940 (1.2); 7.2719 (1.4); 7.1073 (1.8); 7.0975 (1.9); 6.8472 (1.3); 6.8251 (1.2); 4.3066 (0.7); 4.2947 (0.8); 4.1145 (0.6); 4.1033 (1.1); 4.0515 (0.5); 3.5111 (1.0); 2.5103 (2.3); 2.5059 (4.9); 2.5014 (6.6); 2.4969 (4.7); 2.4925 (2.2); 2.2609 (3.5); 1.2449 (16.0) I.1-127: 1 H-NMR (400.1 MHz, d6-DMSO): δ= 7.3803 (2.0); 7.3765 (2.2); 7.3596 (4.3); 7.3560 (4.9); 7.3503 (2.7); 7.3400 (3.0); 7.3340 (4.9); 7.3303 (4.4); 7.3136 (2.5); 7.3101 (2.5); 7.2090 (2.5); 7.2052 (2.9); 7.1946 (9.0); 7.1894 (5.9); 7.1856 (5.6); 7.1761 (4.8); 7.1729 (5.4); 7.1690 (3.6); 7.1650 (3.2); 7.1559 (2.6); 7.1526 (2.8); 7.0723 (5.4); 7.0629 (16.0); 7.0566 (8.2); 7.0369 (3.8); 6.9312 (7.1); 4.7048 (8.2); 4.6648 (9.6); 4.4857 (0.3); 4.4346 (0.3); 4.3883 (0.3); 4.3790 (0.3); 4.3558 (0.3); 4.3214 (0.4); 4.3090 (0.4); 4.2590 (10.2); 4.2189 (8.7); 4.1710 (0.4); 4.1520 (0.4); 4.1467 (0.4); 4.1134 (0.4); 4.0808 (0.4); 4.0718 (0.4); 4.0420 (0.4); 4.0184 (0.4); 3.9887 (0.4); 3.9614 (0.3); 3.9413 (0.3); 3.9202 (0.4); 3.8772 (0.4); 3.8585 (1.8); 3.8483 (3.3); 3.8376 (4.6); 3.8273 (5.2); 3.8171 (4.5); 3.8069 (3.6); 3.7970 (1.7); 3.1694 (0.5); 2.8330 (6.0); 2.8230 (6.2); 2.7935 (7.6); 2.7835 (7.5); 2.6743 (0.7); 2.6696 (0.9); 2.6650 (0.7); 2.5567 (0.6); 2.5522 (0.9); 2.5495 (1.0); 2.5448 (0.8); 2.5230 (2.3); 2.5166 (9.3); 2.5098 (43.7); 2.5053 (97.0); 2.5007 (138.0); 2.4960 (106.3); 2.4916 (51.6); 2.4774 (7.1); 2.4552 (6.4); 2.4478 (2.8); 2.4286 (2.4); 2.4214 (2.2); 2.4054 (5.5); 2.3868 (4.7); 2.3829 (4.6); 2.3655 (3.1); 2.3433 (0.5); 2.3369 (0.4); 2.3322 (0.6); 2.3275 (1.0); 2.3228 (0.8); 2.3018 (3.4); 2.2894 (3.9); 2.2775 (5.8); 2.2651 (5.9); 2.2490 (0.8); 2.2359 (3.9); 2.2272 (6.8); 2.2110 (4.0); 2.1993 (3.1); 2.1927 (2.6); 2.1865 (2.3); 2.1805 (4.6); 2.1754 (2.5); 2.1684 (1.6); 2.1609 (2.6); 2.1561 (3.0); 2.1368 (1.3); 2.0710 (1.2); 1.7703 (1.8); 1.7623 (3.6); 1.7509 (3.5); 1.7401 (3.9); 1.7332 (3.8); 1.7281 (2.6); 1.7207 (3.0); 1.7080 (2.7); 1.6961 (1.5); 0.0082 (0.9) I.1-128: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 7.1469 (2.1); 7.1261 (7.1); 7.1102 (7.6); 7.0899 (2.2); 4.6575 (2.0); 4.6196 (2.3); 4.1138 (1.7); 4.1029 (4.5); 4.0911 (4.6); 4.0808 (1.7); 4.0566 (2.4); 4.0190 (2.0); 3.7240 (0.9); 3.7131 (1.1); 3.7018 (1.2); 3.6920 (1.1); 3.6827 (0.9); 3.4783 (4.2); 3.4669 (6.9); 3.4550 (4.8); 3.4196 (41.7); 3.2278 (28.7); 2.7612 (1.3); 2.7512 (1.4); 2.7216 (1.8); 2.7114 (1.8); 2.6696 (0.6); 2.5100 (29.7); 2.5056 (61.9); 2.5012 (84.2); 2.4967 (59.5); 2.4924 (27.3); 2.4547 (1.9); 2.4326 (2.1); 2.4152 (1.6); 2.4037 (1.4); 2.3933 (1.7); 2.3859 (1.1); 2.3623 (0.8); 2.2763 (16.0); 2.2615 (1.3); 2.2479 (1.3); 2.2316 (0.6); 2.2195 (0.7); 2.2060 (0.8); 2.1495 (0.8); 2.1168 (1.0); 2.0926 (0.8); 2.0728 (0.7); 1.7116 (0.6); 1.7008 (1.0); 1.6805 (0.8); 1.6687 (0.8); 1.6583 (0.6); -0.0002 (1.6) I.1-129: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.3751 (16.0); 7.1396 (1.2); 7.1196 (2.9); 7.0922 (3.1); 7.0721 (1.3); 4.6374 (0.9); 4.5992 (1.0); 4.1524 (1.2); 4.1363 (2.7); 4.1203 (1.3); 4.0416 (1.1); 4.0032 (0.9); 3.6729 (0.6); 3.4076 (8.0); 3.2032 (1.3); 3.1872 (2.7); 3.1710 (1.2); 2.7032 (0.6); 2.6930 (0.6); 2.6635 (0.8); 2.6533 (0.8); 2.5068 (9.7); 2.5024 (13.1); 2.4981 (9.3); 2.3815 (1.2); 2.3602 (1.2); 2.3420 (0.8); 2.3203 (0.7); 2.2714 (7.2); 2.2547 (0.6); 2.2406 (0.6) I.1-130: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 10.6935 (0.5); 7.8181 (3.9); 7.3656 (0.9); 7.3437 (0.8); 7.1954 (0.9); 7.1826 (0.9); 7.1068 (0.8); 7.0899 (1.1); 7.0717 (0.6); 4.7752 (1.1); 4.7356 (1.3); 4.2913 (1.5); 4.2517 (1.4); 3.9036 (0.6); 3.8934 (0.8); 3.8842 (0.8); 3.8722 (0.7); 3.8621 (0.6); 3.5968 (16.0); 3.3206 (69.7); 3.1858 (0.9); 3.1343 (0.7); 3.1224 (0.8); 3.1161 (2.4); 3.1041 (2.2); 3.0979 (2.2); 3.0860 (2.2); 3.0798 (0.7); 3.0679 (0.7); 2.8861 (0.6); 2.8763 (0.6); 2.8491 (0.8); 2.8389 (0.7); 2.7694 (0.8); 2.7609 (0.8); 2.6746 (0.9); 2.6699 (1.2); 2.6653 (0.8); 2.5504 (1.4); 2.5459 (1.0); 2.5402 (1.3); 2.5234 (4.2); 2.5186 (6.2); 2.5100 (67.6); 2.5054 (143.4); 2.5008 (197.1); 2.4962 (137.3); 2.4916 (61.3); 2.4690 (0.6); 2.4264 (1.0); 2.4082 (0.8); 2.4040 (0.8); 2.3869 (0.7); 2.3369 (0.5); 2.3322 (1.0); 2.3276 (1.8); 2.3231 (1.0); 2.3150 (0.7); 2.3031 (1.0); 2.2904 (1.0); 2.2615 (0.7); 2.2508 (1.1); 2.2339 (0.8); 2.2219 (0.6); 2.2154 (0.5); 2.2034 (0.8); 2.1783 (0.6); 1.8628 (0.5); 1.8517 (0.6); 1.8405 (0.6); 1.8332 (0.6); 1.8209 (0.5); 1.1937 (5.4); 1.1755 (11.2); 1.1572 (5.2); 0.0079 (1.6); -0.0002 (51.9); -0.0086 (1.5) I.1-131: 1 H-NMR (400.1 MHz, d 6 -DMSO): δ= 12.3518 (0.4); 12.3435 (0.4); 12.3082 (0.4); 12.2984 (0.3); 7.4050 (1.1); 7.3986 (11.0); 7.3938 (3.9); 7.3825 (4.3); 7.3775 (16.0); 7.3713 (2.1); 7.2635 (12.0); 7.2423 (9.1); 4.6561 (4.4); 4.6174 (5.0); 4.1363 (4.8); 4.0974 (4.3); 3.7350 (0.7); 3.7243 (1.4); 3.7134 (2.0); 3.7023 (2.1); 3.6927 (2.0); 3.6825 (1.6); 3.6723 (0.8); 3.3610 (29.7); 3.1686 (3.1); 2.6860 (3.4); 2.6761 (3.7); 2.6690 (1.5); 2.6643 (1.0); 2.6594 (0.6); 2.6463 (4.1); 2.6364 (4.0); 2.5487 (0.9); 2.5441 (1.2); 2.5394 (1.8); 2.5224 (2.7); 2.5091 (70.4); 2.5045 (154.6); 2.4999 (218.8); 2.4953 (158.4); 2.4907 (75.2); 2.4564 (1.0); 2.4517 (0.4); 2.4417 (0.4); 2.4243 (1.1); 2.4169 (1.1); 2.4000 (2.4); 2.3825 (1.9); 2.3764 (1.8); 2.3591 (1.7); 2.3358 (0.6); 2.3313 (1.2); 2.3258 (5.1); 2.3176 (0.9); 2.3030 (4.1); 2.2923 (2.0); 2.2861 (3.8); 2.2786 (2.2); 2.2678 (3.0); 2.2634 (3.9); 2.2540 (2.9); 2.2374 (0.8); 2.2262 (1.7); 2.2133 (1.8); 2.1972 (1.2); 2.1789 (1.5); 2.1730 (0.8); 2.1668 (1.4); 2.1614 (1.1); 2.1541 (1.1); 2.1487 (1.8); 2.1424 (1.2); 2.1369 (0.9); 2.1295 (1.2); 2.1233 (1.2); 2.1047 (0.7); 2.0709 (0.7); 1.7362 (0.9); 1.7240 (1.4); 1.7128 (1.8); 1.7015 (1.4); 1.6936 (1.6); 1.6883 (1.2); 1.6813 (1.7); 1.6702 (1.1); 1.6561 (0.7); 0.0082 (0.7); 0.0000 (23.2) I.1-132: 1 H-NMR (400.1 MHz, d 6 -DMSO): δ= 11.6290 (3.4); 7.3855 (0.4); 7.3818 (0.5); 7.3649 (1.0); 7.3611 (1.1); 7.3553 (0.6); 7.3452 (0.7); 7.3391 (1.1); 7.3353 (1.0); 7.3189 (0.6); 7.3151 (0.5); 7.2120 (0.6); 7.2081 (0.6); 7.1992 (0.6); 7.1954 (0.8); 7.1920 (1.1); 7.1884 (1.2); 7.1792 (1.1); 7.1760 (1.2); 7.1720 (0.8); 7.1679 (0.8); 7.1589 (0.6); 7.1554 (0.7); 7.0760 (1.1); 7.0599 (1.6); 7.0569 (1.5); 7.0406 (0.8); 4.7255 (1.8); 4.6858 (2.1); 4.2447 (2.2); 4.2045 (1.9); 3.8415 (0.4); 3.8311 (0.7); 3.8205 (1.0); 3.8099 (1.1); 3.7996 (1.0); 3.7898 (0.8); 3.7800 (0.4); 3.5958 (0.7); 3.5787 (1.8); 3.5615 (2.6); 3.5443 (1.9); 3.5271 (0.7); 3.3514 (45.5); 3.1684 (5.7); 2.7907 (1.5); 2.7807 (1.5); 2.7524 (1.8); 2.7424 (1.8); 2.6742 (0.5); 2.6696 (0.7); 2.6650 (0.5); 2.5446 (0.4); 2.5400 (0.9); 2.5231 (1.6); 2.5184 (2.5); 2.5098 (38.6); 2.5052 (84.3); 2.5006 (118.7); 2.4960 (86.2); 2.4914 (41.1); 2.4656 (2.4); 2.4433 (2.0); 2.4272 (1.7); 2.4157 (0.7); 2.4051 (1.7); 2.3988 (1.4); 2.3796 (1.2); 2.3763 (1.1); 2.3578 (0.9); 2.3320 (0.5); 2.3274 (0.8); 2.3228 (0.6); 2.3040 (0.8); 2.2916 (1.0); 2.2798 (1.4); 2.2673 (1.4); 2.2380 (0.8); 2.2271 (1.0); 2.2219 (0.8); 2.2039 (0.9); 2.1978 (0.4); 2.1922 (0.7); 2.1850 (0.6); 2.1795 (0.6); 2.1730 (1.1); 2.1684 (0.6); 2.1608 (0.4); 2.1534 (0.6); 2.1488 (0.7); 2.0721 (0.7); 1.7729 (0.4); 1.7633 (0.8); 1.7520 (0.8); 1.7415 (0.9); 1.7332 (1.0); 1.7292 (0.6); 1.7213 (0.7); 1.7092 (0.6); 1.6974 (0.4); 1.2611 (15.5); 1.2593 (16.0); 1.2439 (15.5); 1.2422 (16.0); 0.0083 (0.5) I.1-133: 1 H-NMR (400.1 MHz, d6-DMSO): δ= 7.5844 (6.7); 7.5807 (7.4); 7.5644 (8.5); 7.5607 (8.7); 7.3707 (8.1); 7.3511 (16.0); 7.3313 (9.2); 7.2291 (7.7); 7.2273 (7.2); 7.2256 (8.2); 7.2098 (6.2); 7.2062 (6.2); 4.7040 (7.5); 4.6628 (9.2); 4.3067 (8.8); 4.2654 (7.4); 3.8384 (1.3); 3.8279 (2.5); 3.8173 (3.6); 3.8074 (4.1); 3.7979 (3.6); 3.7874 (2.9); 3.7769 (1.3); 3.7634 (0.4); 3.7424 (0.4); 3.5954 (1.0); 3.5574 (0.8); 3.5198 (0.6); 2.6743 (5.6); 2.6637 (5.7); 2.6344 (7.3); 2.6237 (7.2); 2.5507 (0.3); 2.5460 (0.3); 2.5407 (0.4); 2.5238 (0.7); 2.5191 (1.1); 2.5105 (21.2); 2.5059 (47.2); 2.5013 (67.0); 2.4966 (48.9); 2.4921 (23.6); 2.4808 (2.8); 2.4628 (2.5); 2.4516 (1.0); 2.4492 (1.0); 2.4391 (5.0); 2.4324 (8.3); 2.4224 (3.8); 2.4161 (4.4); 2.4109 (8.2); 2.3925 (6.3); 2.3709 (5.8); 2.3322 (2.8); 2.3198 (2.7); 2.3078 (5.0); 2.2958 (5.1); 2.2740 (3.6); 2.2701 (5.7); 2.2636 (4.9); 2.2613 (4.7); 2.2579 (3.9); 2.2525 (2.6); 2.2470 (1.5); 2.2402 (3.6); 2.2334 (1.5); 2.2280 (1.2); 2.2212 (2.2); 2.2155 (1.9); 2.1969 (1.0); 2.0720 (14.2); 1.8181 (0.9); 1.8127 (0.6); 1.7960 (1.8); 1.7906 (2.2); 1.7841 (3.3); 1.7768 (2.3); 1.7735 (3.0); 1.7668 (2.0); 1.7613 (2.8); 1.7541 (2.1); 1.7424 (2.4); 1.7305 (1.3); 0.0000 (8.9) I.1-134: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.1491 (1.0); 8.1259 (0.9); 8.0619 (1.0); 8.0387 (1.0); 7.2207 (2.8); 7.2080 (7.7); 7.1973 (1.0); 7.1550 (2.3); 7.1410 (3.2); 7.1365 (4.8); 4.7742 (1.6); 4.7675 (1.8); 4.7354 (1.8); 4.7284 (2.0); 4.3341 (1.0); 4.3225 (1.2); 4.3122 (1.2); 4.3007 (1.1); 4.1557 (0.8); 4.1407 (0.9); 4.1197 (0.7); 4.0955 (0.7); 4.0630 (2.0); 4.0249 (1.6); 3.6475 (1.1); 3.3868 (1.0); 3.3332 (112.0); 3.2832 (1.8); 3.1655 (2.6); 2.6744 (1.6); 2.6698 (2.5); 2.6652 (1.8); 2.6255 (1.9); 2.6091 (4.5); 2.5905 (5.3); 2.5715 (2.6); 2.5617 (2.4); 2.5567 (2.4); 2.5519 (1.7); 2.5233 (4.7); 2.5186 (7.5); 2.5099 (139.3); 2.5053 (308.9); 2.5007 (435.6); 2.4960 (304.6); 2.4915 (135.2); 2.4549 (4.4); 2.4504 (6.4); 2.4458 (5.2); 2.3856 (1.6); 2.3320 (2.1); 2.3275 (2.6); 2.3228 (2.2); 2.3120 (1.7); 2.2777 (2.2); 2.2539 (1.5); 2.2202 (0.8); 2.0730 (0.8); 2.0333 (0.9); 2.0050 (1.1); 1.9821 (1.0); 1.8305 (1.6); 1.2443 (0.9); 1.1439 (6.3); 1.1403 (4.4); 1.1253 (13.2); 1.1215 (8.8); 1.1063 (6.2); 1.1026 (4.3); 0.8546 (7.6); 0.8475 (11.5); 0.8375 (10.4); 0.8294 (16.0); 0.8106 (4.0); 0.0506 (1.1); 0.0079 (5.7); -0.0002 (207.1); -0.0085 (6.1); -0.0506 (2.2) I.1-135: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.6528 (0.6); 8.6380 (1.2); 8.6238 (0.6); 8.5781 (1.1); 8.5760 (1.3); 8.5739 (1.3); 8.5718 (1.2); 8.5654 (1.2); 8.5634 (1.3); 8.5613 (1.3); 8.5591 (1.1); 7.9472 (0.5); 7.9318 (1.0); 7.9285 (1.0); 7.9123 (0.6); 7.9089 (0.6); 7.4323 (0.8); 7.4190 (0.9); 7.3988 (1.8); 7.3775 (1.6); 7.3603 (0.7); 7.3563 (0.8); 7.3501 (0.4); 7.3407 (0.5); 7.3344 (0.8); 7.3305 (0.7); 7.3142 (0.4); 7.3104 (0.4); 7.2071 (0.4); 7.2031 (0.5); 7.1942 (0.4); 7.1903 (0.6); 7.1873 (0.8); 7.1833 (0.9); 7.1745 (0.8); 7.1708 (0.9); 7.1668 (0.6); 7.1629 (0.6); 7.1541 (0.5); 7.1504 (0.5); 7.0785 (0.8); 7.0628 (1.1); 7.0593 (1.1); 7.0432 (0.6); 4.7472 (1.3); 4.7077 (1.5); 4.3997 (2.5); 4.3840 (2.4); 4.2485 (1.6); 4.2086 (1.4); 3.8481 (0.4); 3.8371 (0.6); 3.8266 (0.9); 3.8166 (1.1); 3.8067 (0.9); 3.7961 (0.7); 3.7848 (0.5); 3.7295 (0.4); 3.5405 (16.0); 3.1687 (4.8); 2.6757 (0.4); 2.6710 (0.5); 2.6664 (0.4); 2.6508 (1.1); 2.6396 (1.1); 2.6155 (1.4); 2.6042 (1.3); 2.5413 (0.4); 2.5244 (0.8); 2.5198 (1.2); 2.5111 (26.6); 2.5065 (60.5); 2.5019 (86.4); 2.4973 (61.2); 2.4926 (27.2); 2.4625 (0.4); 2.4577 (0.4); 2.4533 (0.4); 2.4114 (0.4); 2.3924 (0.5); 2.3886 (0.5); 2.3693 (1.0); 2.3449 (2.1); 2.3332 (0.6); 2.3282 (1.2); 2.3234 (1.9); 2.3094 (1.3); 2.2913 (0.9); 2.2878 (1.4); 2.2783 (0.9); 2.2674 (1.1); 2.2542 (1.1); 2.2498 (0.5); 2.2366 (0.4); 2.2255 (0.6); 2.2125 (0.6); 2.1656 (0.4); 2.1464 (0.7); 2.1419 (0.4); 2.1341 (0.5); 2.1270 (0.4); 2.1222 (0.6); 2.1148 (0.9); 2.1101 (0.5); 2.0954 (0.5); 2.0907 (0.6); 2.0735 (4.4); 1.8185 (0.4); 1.8059 (0.5); 1.7951 (0.7); 1.7847 (0.6); 1.7737 (0.6); 1.7634 (0.7); 1.7529 (0.4) I.1-136: 1 H-NMR (400.1 MHz, d6-DMSO): δ= 7.4210 (6.6); 7.3999 (16.0); 7.3939 (12.1); 7.3788 (12.0); 7.3729 (15.2); 7.3517 (7.3); 7.3017 (5.6); 7.2966 (5.8); 7.2821 (5.9); 7.2767 (6.8); 7.2729 (6.5); 7.2675 (6.0); 7.2530 (5.6); 7.2479 (5.6); 7.1011 (5.8); 7.0947 (5.9); 7.0902 (6.2); 7.0849 (6.1); 7.0798 (5.4); 7.0738 (5.2); 7.0693 (5.1); 6.8936 (7.3); 4.6306 (12.5); 4.5918 (14.5); 4.1363 (15.9); 4.0974 (13.7); 3.7886 (2.3); 3.7773 (5.2); 3.7663 (6.5); 3.7571 (7.5); 3.7465 (6.8); 3.7355 (5.5); 3.7242 (2.6); 3.3864 (1.7); 3.3774 (0.8); 3.3371 (642.8); 3.2858 (0.5); 3.2699 (0.4); 3.1703 (0.7); 2.6803 (0.4); 2.6757 (0.9); 2.6711 (1.3); 2.6666 (1.0); 2.6619 (0.4); 2.5558 (0.3); 2.5513 (0.5); 2.5467 (0.5); 2.5415 (0.5); 2.5247 (3.1); 2.5199 (4.4); 2.5112 (76.3); 2.5067 (164.1); 2.5021 (231.1); 2.4976 (158.5); 2.4930 (75.4); 2.4664 (12.9); 2.4552 (12.2); 2.4024 (2.5); 2.3841 (3.3); 2.3791 (3.1); 2.3606 (8.3); 2.3421 (7.4); 2.3373 (7.2); 2.3291 (2.1); 2.3191 (7.0); 2.2992 (6.4); 2.2846 (7.7); 2.2752 (9.1); 2.2608 (9.4); 2.2429 (2.9); 2.2333 (4.4); 2.2191 (4.3); 2.1494 (3.2); 2.1300 (6.9); 2.1253 (14.6); 2.1178 (5.0); 2.1116 (4.4); 2.1027 (13.5); 2.0897 (11.6); 2.0800 (4.5); 2.0747 (5.5); 2.0717 (4.2); 2.0675 (9.9); 2.0562 (2.5); 1.7439 (3.0); 1.7301 (4.2); 1.7193 (5.0); 1.7118 (4.1); 1.7088 (4.7); 1.6980 (4.6); 1.6948 (3.8); 1.6870 (4.3); 1.6769 (3.4); 1.6627 (2.4) I.1-137: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 9.0177 (7.8); 9.0141 (8.9); 9.0070 (8.2); 9.0031 (8.7); 8.6645 (5.0); 8.6437 (5.5); 8.5983 (3.3); 8.5842 (6.2); 8.0113 (8.1); 7.9896 (10.5); 7.8133 (7.6); 7.7952 (9.4); 7.7741 (7.4); 7.6981 (5.9); 7.6869 (6.0); 7.6764 (5.6); 7.6656 (6.3); 7.5930 (9.0); 7.5756 (7.9); 7.3724 (2.3); 7.3522 (5.1); 7.3304 (4.8); 7.3059 (2.5); 7.1919 (2.8); 7.1723 (5.6); 7.1595 (5.2); 7.1428 (2.7); 7.0663 (4.3); 7.0513 (6.0); 7.0321 (3.8); 4.8225 (2.4); 4.8076 (2.5); 4.7849 (6.2); 4.7704 (6.5); 4.7398 (6.6); 4.7247 (8.7); 4.7017 (3.8); 4.6810 (7.9); 4.2205 (8.8); 4.1807 (7.9); 3.8393 (12.3); 3.8284 (14.2); 3.8170 (15.8); 3.8076 (16.0); 3.7981 (15.4); 3.2169 (2.0); 3.1660 (14.6); 2.7573 (2.0); 2.6750 (3.6); 2.6701 (5.2); 2.6655 (4.4); 2.6221 (5.0); 2.6112 (5.4); 2.5870 (6.2); 2.5760 (6.7); 2.5566 (2.5); 2.5237 (8.2); 2.5190 (14.1); 2.5103 (317.8); 2.5057 (712.5); 2.5011 (1013.9); 2.4965 (712.6); 2.4919 (319.1); 2.4557 (7.8); 2.4510 (10.0); 2.4464 (7.4); 2.4012 (2.7); 2.3753 (2.6); 2.3564 (3.2); 2.3325 (9.5); 2.3280 (7.1); 2.3232 (5.2); 2.3131 (5.7); 2.2975 (8.2); 2.2895 (5.6); 2.2755 (8.6); 2.2698 (5.8); 2.2624 (7.9); 2.2561 (6.1); 2.2455 (7.9); 2.2407 (7.7); 2.2324 (6.4); 2.2146 (3.2); 2.2038 (3.8); 2.1908 (3.9); 2.1485 (2.5); 2.1291 (3.9); 2.1050 (3.2); 2.0978 (4.9); 2.0734 (6.6); 2.0544 (1.7); 1.7691 (1.9); 1.7562 (3.2); 1.7457 (4.0); 1.7322 (3.6); 1.7138 (3.4); 1.7026 (2.6); 0.0505 (2.3); 0.0080 (18.1); 0.0063 (5.3); 0.0055 (5.9); 0.0047 (7.1); 0.0038 (9.5); -0.0002 (601.3); - 0.0027 (33.5); -0.0051 (8.4); -0.0060 (5.9); -0.0068 (5.3); -0.0085 (17.3); -0.0504 (4.4) I.1-139: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.4300 (2.3); 7.4261 (2.5); 7.4103 (2.6); 7.4063 (2.6); 7.3109 (1.0); 7.3070 (1.1); 7.2901 (2.0); 7.2717 (1.6); 7.2677 (1.4); 7.1583 (2.5); 7.1551 (2.6); 7.1375 (2.0); 7.1342 (2.0); 7.1266 (2.0); 7.1059 (7.5); 7.0927 (8.0); 7.0721 (2.0); 6.9891 (1.5); 6.9857 (1.5); 6.9698 (2.2); 6.9667 (2.2); 6.9509 (1.2); 6.9475 (1.1); 4.6533 (2.0); 4.6148 (2.2); 4.3963 (0.8); 4.3654 (1.2); 4.3547 (3.2); 4.3445 (3.3); 4.3350 (1.6); 4.2451 (3.3); 4.2340 (4.5); 4.2227 (2.2); 4.0468 (2.3); 4.0084 (2.0); 3.7270 (0.7); 3.7164 (1.0); 3.7062 (1.1); 3.6960 (1.0); 3.6853 (0.7); 3.3456 (0.8); 3.3231 (348.6); 3.2993 (19.9); 3.2734 (1.4); 2.7850 (1.4); 2.7751 (1.4); 2.7455 (1.8); 2.7354 (1.7); 2.6704 (0.7); 2.5237 (1.7); 2.5102 (43.8); 2.5057 (93.7); 2.5012 (129.4); 2.4967 (92.7); 2.4923 (43.5); 2.4651 (2.1); 2.4429 (2.0); 2.4254 (1.9); 2.4035 (1.9); 2.3813 (1.2); 2.3636 (1.0); 2.3397 (0.9); 2.3326 (0.7); 2.3280 (0.8); 2.2609 (16.0); 2.2412 (1.4); 2.2275 (1.2); 2.1994 (0.8); 2.1859 (0.8); 2.1525 (0.5); 2.1335 (0.8); 2.1205 (0.6); 2.1143 (0.6); 2.1087 (0.6); 2.1023 (1.0); 2.0777 (0.6); 1.7226 (0.7); 1.7116 (0.8); 1.7016 (0.7); 1.6915 (0.7); 1.6799 (0.8); 1.6684 (0.5); -0.0002 (7.5) I.1-140: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 7.1469 (1.2); 7.1265 (4.1); 7.1094 (4.4); 7.0890 (1.3); 4.6566 (1.2); 4.6183 (1.3); 4.1470 (1.3); 4.1310 (2.8); 4.1146 (1.5); 4.0634 (1.4); 4.0255 (1.3); 3.7225 (0.6); 3.7121 (0.7); 3.7018 (0.6); 3.3629 (60.9); 2.7634 (0.8); 2.7533 (0.8); 2.7238 (1.1); 2.7137 (1.0); 2.6616 (2.2); 2.6450 (4.4); 2.6284 (2.0); 2.5098 (16.5); 2.5056 (34.2); 2.5012 (46.7); 2.4968 (33.3); 2.4926 (15.6); 2.4501 (1.2); 2.4280 (1.3); 2.4104 (0.9); 2.4026 (0.7); 2.3882 (1.0); 2.3788 (0.6); 2.2905 (0.6); 2.2762 (9.8); 2.2664 (1.0); 2.2524 (0.7); 2.1279 (0.5); 2.0600 (16.0); 1.7180 (0.5) I.1-142: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.1471 (2.0); 7.1270 (5.9); 7.1079 (6.5); 7.0874 (2.0); 4.6492 (1.8); 4.6111 (2.0); 4.0552 (2.0); 4.0382 (1.5); 4.0203 (5.5); 4.0029 (5.1); 3.9851 (1.7); 3.7231 (0.7); 3.7126 (1.0); 3.7022 (1.1); 3.6920 (1.0); 3.6815 (0.7); 3.4004 (1.7); 3.3681 (218.9); 3.1673 (0.6); 2.7323 (1.4); 2.7221 (1.4); 2.6927 (1.8); 2.6824 (1.8); 2.6759 (0.6); 2.6714 (0.8); 2.6667 (0.6); 2.5416 (0.7); 2.5248 (2.2); 2.5201 (3.2); 2.5114 (48.6); 2.5069 (103.0); 2.5023 (138.9); 2.4977 (96.6); 2.4931 (43.3); 2.4272 (2.0); 2.4199 (0.5); 2.4121 (0.5); 2.4053 (2.0); 2.3952 (1.2); 2.3876 (1.6); 2.3766 (0.8); 2.3710 (0.8); 2.3657 (1.6); 2.3532 (0.8); 2.3336 (0.6); 2.3291 (0.8); 2.3244 (0.6); 2.2887 (1.0); 2.2761 (14.5); 2.2643 (1.5); 2.2504 (1.2); 2.2224 (0.7); 2.2090 (0.8); 2.1501 (0.7); 2.1371 (0.6); 2.1313 (0.5); 2.1247 (0.5); 2.1185 (0.8); 2.1126 (0.5); 2.0993 (0.5); 2.0934 (0.5); 2.0752 (0.6); 1.7062 (0.6); 1.6952 (0.8); 1.6843 (0.6); 1.6745 (0.6); 1.6632 (0.7); 1.1521 (7.4); 1.1343 (16.0); 1.1165 (7.2); -0.0002 (8.8) I.1-143: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.9947 (5.4); 7.9910 (5.3); 7.9734 (5.5); 7.9223 (2.0); 7.9024 (1.8); 7.7391 (2.6); 7.7241 (5.3); 7.7203 (5.7); 7.7078 (16.0); 7.7041 (13.2); 7.6893 (2.8); 7.6077 (3.8); 7.6024 (3.7); 7.5912 (3.7); 7.5880 (4.5); 7.5819 (3.7); 7.5722 (3.0); 7.5664 (2.4); 7.1599 (8.3); 7.1402 (11.6); 7.0972 (2.2); 7.0588 (12.5); 7.0388 (8.4); 4.5621 (4.4); 4.5244 (5.0); 4.2770 (5.7); 4.2642 (8.9); 4.2494 (6.7); 4.1467 (2.3); 3.9598 (5.2); 3.9205 (4.7); 3.8923 (6.1); 3.8768 (7.6); 3.8646 (4.6); 3.4881 (3.7); 3.4761 (5.0); 3.4642 (4.4); 3.4459 (3.7); 3.4324 (3.6); 3.3759 (2.2); 3.3502 (7.2); 3.3230 (3678.0); 3.2991 (180.8); 3.1748 (3.0); 3.1617 (2.9); 2.6749 (4.5); 2.6703 (6.3); 2.6658 (4.6); 2.5404 (3.8); 2.5236 (17.3); 2.5103 (395.8); 2.5057 (840.7); 2.5012 (1154.2); 2.4966 (811.6); 2.4922 (370.4); 2.3538 (4.1); 2.3432 (5.1); 2.3281 (8.0); 2.3234 (7.7); 2.3136 (4.9); 2.3031 (6.7); 2.2918 (34.9); 2.2653 (4.5); 2.2560 (2.6); 2.2406 (3.0); 2.2310 (3.2); 2.2168 (3.3); 2.1888 (1.9); 2.0729 (3.6); 2.0529 (2.2); 2.0205 (2.3); 1.9737 (4.2); 1.9517 (3.8); 1.9338 (3.4); 1.9117 (3.7); 1.5148 (1.8); -0.0002 (34.6) I.1-144: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 10.4881 (1.2); 8.1118 (0.9); 8.1095 (1.0); 8.0910 (1.0); 8.0887 (1.0); 7.8875 (1.0); 7.8838 (1.1); 7.8676 (1.1); 7.8640 (1.1); 7.6073 (0.6); 7.6032 (0.6); 7.5888 (0.7); 7.5852 (0.8); 7.5825 (0.6); 7.5681 (0.6); 7.5640 (0.6); 7.2204 (0.8); 7.2174 (0.8); 7.2019 (1.0); 7.2006 (1.0); 7.1991 (1.0); 7.1977 (1.0); 7.1823 (0.8); 7.1793 (0.8); 7.0880 (0.6); 4.7547 (0.7); 4.7150 (0.8); 4.3180 (0.9); 4.2781 (0.8); 3.9160 (0.5); 3.8292 (16.0); 3.3433 (14.2); 2.8442 (0.6); 2.8322 (0.6); 2.8069 (0.8); 2.7949 (0.7); 2.5970 (0.8); 2.5768 (0.7); 2.5596 (0.5); 2.5395 (0.7); 2.5240 (0.6); 2.5193 (0.8); 2.5106 (10.6); 2.5060 (22.8); 2.5014 (31.7); 2.4968 (22.1); 2.4922 (9.7); 2.4418 (0.7); 2.2978 (0.6); 2.2851 (0.6); 2.2484 (0.6); -0.0002 (2.8) I.1-145: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.0020 (8.6); 7.9840 (6.4); 7.9805 (16.0); 7.7422 (5.7); 7.7370 (5.2); 7.7209 (4.6); 7.7157 (4.9); 7.1689 (5.4); 7.1495 (8.4); 7.0802 (9.1); 7.0603 (6.0); 4.6046 (3.1); 4.5662 (3.5); 4.2941 (4.0); 4.2801 (6.9); 4.2665 (4.6); 3.9841 (3.6); 3.9457 (3.2); 3.9084 (3.6); 3.8978 (4.5); 3.8929 (5.2); 3.8845 (2.5); 3.5524 (1.8); 3.5418 (1.8); 3.3331 (327.8); 3.1846 (2.2); 2.6856 (1.6); 2.5808 (1.5); 2.5390 (3.6); 2.5256 (88.4); 2.5211 (193.0); 2.5164 (270.1); 2.5118 (187.0); 2.5072 (84.0); 2.4548 (2.4); 2.4435 (2.6); 2.4138 (2.7); 2.4037 (3.1); 2.3574 (2.2); 2.3389 (2.8); 2.3014 (24.0); 2.2819 (2.2); 2.2672 (1.9); 2.2569 (2.3); 2.2425 (2.1); 2.0661 (2.9); 2.0457 (3.0); 2.0273 (3.0); 2.0062 (2.0); 1.5494 (1.5); 0.0156 (2.3) I.1-146: 1 H-NMR (400.0 MHz, CDCl3): δ= 7.5215 (0.9); 7.3826 (14.6); 7.3724 (0.5); 7.3621 (16.5); 7.2626 (183.5); 7.2570 (12.6); 7.1286 (1.1); 7.1191 (1.6); 7.1130 (1.6); 7.1039 (3.7); 7.0913 (2.6); 7.0888 (2.5); 7.0852 (2.9); 7.0772 (3.8); 7.0703 (1.8); 7.0651 (2.0); 7.0609 (4.2); 7.0573 (7.8); 7.0498 (11.2); 7.0472 (6.9); 7.0411 (10.1); 7.0338 (4.0); 7.0306 (6.0); 7.0272 (7.6); 7.0219 (7.4); 7.0127 (1.0); 7.0067 (6.4); 7.0015 (6.1); 5.4813 (2.4); 5.2999 (8.8); 4.8500 (4.8); 4.8464 (4.7); 4.8114 (5.4); 4.8076 (5.2); 4.2343 (7.0); 4.1957 (6.2); 3.9418 (1.1); 3.9306 (2.3); 3.9198 (2.9); 3.9095 (3.3); 3.8996 (2.9); 3.8888 (2.4); 3.8779 (1.1); 3.5433 (0.6); 3.5256 (1.3); 3.5092 (2.9); 3.4914 (5.9); 3.4761 (6.0); 3.4736 (6.2); 3.4715 (5.8); 3.4563 (5.8); 3.4390 (3.0); 3.4219 (1.3); 3.4049 (0.6); 2.7820 (8.4); 2.7644 (16.0); 2.7470 (7.1); 2.5969 (5.0); 2.5860 (5.0); 2.5607 (5.7); 2.5498 (5.6); 2.5240 (1.0); 2.5039 (1.3); 2.5005 (1.2); 2.4805 (3.6); 2.4609 (3.3); 2.4574 (3.1); 2.4380 (3.1); 2.4276 (3.6); 2.4129 (4.2); 2.4035 (5.0); 2.3890 (5.0); 2.3847 (1.8); 2.3701 (1.4); 2.3605 (2.3); 2.3462 (2.2); 2.2757 (2.0); 2.2565 (3.1); 2.2518 (1.9); 2.2430 (2.4); 2.2375 (2.0); 2.2325 (2.6); 2.2240 (3.3); 2.2190 (2.2); 2.2136 (1.5); 2.2048 (2.1); 2.1997 (2.6); 2.1808 (1.4); 2.1412 (6.3); 2.1189 (6.2); 2.1050 (5.4); 2.0827 (5.3); 1.8164 (1.6); 1.8051 (1.8); 1.8023 (2.0); 1.7913 (2.3); 1.7818 (2.2); 1.7785 (1.9); 1.7724 (1.8); 1.7692 (2.2); 1.7580 (2.0); 1.7488 (1.5); 1.7457 (1.4); 1.7342 (1.2); 0.0080 (1.5); -0.0002 (51.8); -0.0085 (1.4) I.1-147: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 7.1493 (1.8); 7.1289 (7.4); 7.1156 (8.2); 7.0949 (1.9); 4.6625 (5.2); 4.6584 (7.2); 4.6566 (7.6); 4.6527 (5.5); 4.6189 (2.4); 4.0542 (2.3); 4.0160 (2.0); 3.7227 (0.7); 3.7121 (1.0); 3.7017 (1.2); 3.6913 (1.0); 3.6808 (0.8); 3.5666 (2.3); 3.5605 (5.0); 3.5544 (2.3); 3.3988 (0.8); 3.3677 (137.6); 2.8045 (1.5); 2.7943 (1.5); 2.7645 (1.9); 2.7543 (1.9); 2.6716 (0.5); 2.5249 (1.0); 2.5202 (1.6); 2.5116 (30.6); 2.5071 (65.4); 2.5025 (89.4); 2.4980 (63.0); 2.4934 (29.0); 2.4784 (2.6); 2.4695 (0.6); 2.4603 (2.0); 2.4384 (2.2); 2.4154 (1.2); 2.3971 (1.0); 2.3919 (0.9); 2.3735 (0.8); 2.3293 (0.6); 2.2868 (1.2); 2.2779 (16.0); 2.2625 (1.4); 2.2493 (1.4); 2.2325 (0.5); 2.2208 (0.8); 2.2079 (0.9); 2.1667 (0.6); 2.1478 (0.8); 2.1350 (0.7); 2.1288 (0.6); 2.1227 (0.6); 2.1165 (1.0); 2.1108 (0.6); 2.0969 (0.6); 2.0914 (0.7); 2.0721 (0.5); 1.7081 (0.7); 1.6967 (0.9); 1.6857 (0.8); 1.6764 (0.8); 1.6648 (0.8); 1.6536 (0.5); -0.0002 (3.3) I.1-148: 1 H-NMR (400.1 MHz, d 6 -DMSO): δ= 12.5995 (0.3); 12.5697 (0.4); 12.5511 (0.5); 12.5463 (0.4); 12.5223 (0.5); 12.4648 (0.4); 12.4379 (0.4); 7.3853 (1.4); 7.3652 (3.4); 7.3414 (3.4); 7.3197 (1.9); 7.2747 (0.7); 7.2564 (0.8); 7.2304 (1.0); 7.2122 (2.2); 7.1924 (3.7); 7.1797 (4.0); 7.1592 (2.1); 7.0754 (3.3); 7.0579 (5.0); 7.0392 (2.5); 4.7722 (3.3); 4.7485 (10.2); 4.7243 (16.0); 4.7001 (4.0); 4.6850 (6.7); 4.2406 (6.5); 4.2007 (5.7); 3.8510 (1.0); 3.8408 (2.0); 3.8308 (2.8); 3.8203 (3.4); 3.8107 (2.9); 3.7991 (2.2); 3.7910 (1.1); 3.5879 (0.4); 3.5774 (0.3); 3.5542 (0.6); 3.5450 (0.4); 3.3775 (42.3); 3.3101 (2.3); 3.2937 (1.6); 3.2848 (1.2); 3.2669 (1.0); 3.2543 (0.8); 3.2122 (0.5); 3.1963 (0.4); 3.1810 (0.4); 3.1719 (6.6); 3.1700 (6.3); 3.1686 (7.7); 2.8345 (0.5); 2.8151 (1.0); 2.8059 (3.6); 2.7964 (4.0); 2.7670 (4.4); 2.7575 (4.2); 2.6696 (1.4); 2.5478 (1.2); 2.5400 (0.7); 2.5040 (226.0); 2.5006 (244.5); 2.4646 (5.8); 2.4479 (5.0); 2.4250 (5.2); 2.4019 (3.8); 2.3827 (3.7); 2.3620 (2.5); 2.3271 (1.7); 2.3079 (2.2); 2.2959 (2.4); 2.2843 (3.2); 2.2715 (3.5); 2.2556 (0.8); 2.2421 (2.2); 2.2305 (3.1); 2.2099 (2.5); 2.1972 (2.0); 2.1779 (2.8); 2.1658 (1.2); 2.1571 (2.0); 2.1347 (0.8); 2.0751 (1.1); 2.0718 (1.2); 1.7679 (1.2); 1.7588 (2.3); 1.7472 (2.3); 1.7371 (2.7); 1.7282 (2.6); 1.7162 (2.1); 1.7045 (1.7); 1.6931 (1.0); 1.3458 (0.3); 1.3280 (0.6); 1.3112 (0.4); 1.2354 (0.3); 0.0082 (1.1); 0.0033 (24.6); 0.0013 (23.4) I.1-149: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.4636 (0.7); 8.4502 (1.2); 8.4356 (0.6); 7.3295 (1.5); 7.3140 (2.3); 7.3103 (3.7); 7.2986 (1.2); 7.2932 (3.6); 7.2466 (1.7); 7.2332 (6.2); 7.2133 (4.0); 7.1397 (2.1); 7.1196 (7.0); 7.1023 (7.7); 7.0817 (2.3); 4.6713 (2.0); 4.6331 (2.2); 4.2544 (2.2); 4.2455 (2.5); 4.2400 (2.5); 4.2311 (2.3); 4.0080 (2.3); 3.9700 (2.0); 3.7475 (0.7); 3.7366 (1.0); 3.7260 (1.0); 3.7162 (1.0); 3.7055 (0.7); 3.3162 (153.6); 3.2651 (0.6); 3.1682 (0.6); 2.6741 (0.5); 2.6695 (0.7); 2.6646 (0.5); 2.5909 (1.3); 2.5799 (1.3); 2.5561 (1.6); 2.5451 (1.5); 2.5228 (1.8); 2.5180 (2.6); 2.5094 (45.4); 2.5049 (98.1); 2.5003 (136.7); 2.4957 (96.1); 2.4912 (43.6); 2.3661 (0.6); 2.3467 (1.2); 2.3272 (1.8); 2.3049 (1.0); 2.2744 (16.0); 2.2577 (1.2); 2.2475 (1.3); 2.2337 (1.3); 2.2158 (0.7); 2.2098 (1.8); 2.1873 (1.7); 2.1750 (1.5); 2.1524 (1.4); 2.0640 (0.8); 2.0519 (0.6); 2.0404 (0.7); 2.0328 (0.9); 2.0085 (0.8); 1.7348 (0.6); 1.7242 (0.9); 1.7134 (0.7); 1.7020 (0.7); 1.6923 (0.7); -0.0002 (0.5) I.1-150: 1 H-NMR (400.1 MHz, d 6 -DMSO): δ= 11.4828 (0.9); 7.1786 (0.3); 7.0645 (0.4); 4.7372 (0.5); 4.6976 (0.6); 4.2484 (0.6); 4.2087 (0.5); 3.4007 (1.3); 2.7735 (16.0); 2.7376 (0.4); 2.7275 (0.4); 2.6998 (0.5); 2.6897 (0.5); 2.5098 (2.3); 2.5053 (5.1); 2.5007 (7.2); 2.4961 (5.3); 2.4916 (2.5); 2.4232 (0.5); 2.4012 (0.5); 2.3973 (0.4); 2.3857 (0.4); 2.3769 (0.3); 2.3637 (0.4); 2.2811 (0.4); 2.2687 (0.4) I.1-151: 1 H-NMR (400.1 MHz, CDCl 3 ): δ= 7.2638 (13.5); 7.0981 (0.6); 7.0862 (0.4); 7.0826 (0.4); 7.0795 (0.5); 7.0757 (0.6); 7.0731 (0.6); 7.0631 (0.4); 7.0566 (1.8); 7.0497 (1.8); 7.0462 (1.2); 7.0411 (1.9); 7.0329 (0.7); 7.0303 (0.7); 6.1081 (0.4); 4.8632 (0.9); 4.8597 (0.9); 4.8244 (1.0); 4.8208 (1.0); 4.2666 (1.3); 4.2278 (1.1); 3.9706 (0.4); 3.9601 (0.5); 3.9499 (0.7); 3.9398 (0.5); 3.9292 (0.4); 3.7080 (16.0); 3.5190 (0.5); 3.5143 (0.5); 3.5102 (0.3); 3.5019 (1.2); 3.4994 (1.1); 3.4947 (0.5); 3.4892 (1.2); 3.4862 (1.3); 3.4782 (0.3); 3.4741 (0.5); 3.4697 (0.5); 2.6137 (0.9); 2.6027 (0.9); 2.5775 (1.1); 2.5664 (1.1); 2.5387 (2.0); 2.5306 (0.8); 2.5240 (2.2); 2.5179 (0.5); 2.5091 (2.4); 2.4888 (0.6); 2.4845 (0.5); 2.4657 (0.6); 2.4400 (0.6); 2.4254 (0.7); 2.4157 (0.8); 2.4013 (0.9); 2.3972 (0.4); 2.3728 (0.4); 2.3586 (0.5); 2.3027 (0.4); 2.2838 (0.7); 2.2787 (0.5); 2.2703 (0.6); 2.2650 (0.6); 2.2595 (0.6); 2.2513 (0.8); 2.2461 (0.6); 2.2409 (0.4); 2.2323 (0.5); 2.2269 (0.6); 2.2081 (0.3); 2.1913 (1.2); 2.1695 (1.1); 2.1551 (1.0); 2.1332 (1.0); 1.8559 (0.3); 1.8536 (0.4); 1.8427 (0.4); 1.8326 (0.4); 1.8297 (0.4); 1.8234 (0.3); 1.8207 (0.4); 1.8184 (0.3); 1.8097 (0.4) I.1-152: 1 H-NMR (400.1 MHz, CDCl3): δ= 7.3818 (1.8); 7.3778 (2.9); 7.3735 (0.8); 7.3587 (4.4); 7.3528 (0.6); 7.3104 (2.3); 7.3056 (0.7); 7.2922 (4.4); 7.2721 (2.5); 7.2594 (42.6); 7.2336 (1.6); 7.2203 (0.6); 7.2153 (2.2); 7.2103 (0.4); 7.1967 (0.6); 7.1313 (1.0); 7.1101 (8.8); 7.1047 (9.6); 7.0894 (0.6); 7.0836 (1.1); 4.8593 (2.1); 4.8215 (2.3); 4.2300 (3.0); 4.2131 (6.4); 4.1961 (3.3); 4.0170 (2.2); 3.9791 (2.0); 3.8450 (0.4); 3.8342 (0.7); 3.8238 (1.0); 3.8131 (1.2); 3.8027 (1.0); 3.7922 (0.8); 3.7818 (0.4); 3.1055 (3.4); 3.0885 (6.6); 3.0716 (3.2); 2.6202 (1.4); 2.6099 (1.4); 2.5814 (1.8); 2.5712 (1.8); 2.5398 (0.3); 2.5212 (0.4); 2.5158 (0.4); 2.4970 (1.1); 2.4784 (1.0); 2.4733 (0.9); 2.4546 (0.9); 2.4314 (0.9); 2.4171 (1.0); 2.4070 (1.2); 2.3927 (1.2); 2.3747 (0.4); 2.3642 (0.6); 2.3500 (0.6); 2.3250 (16.0); 2.3149 (2.1); 2.2927 (1.8); 2.2761 (1.4); 2.2540 (1.4); 2.2483 (0.5); 2.2288 (0.8); 2.2242 (0.4); 2.2154 (0.5); 2.2096 (0.5); 2.2045 (0.6); 2.1962 (0.9); 2.1914 (0.5); 2.1854 (0.3); 2.1770 (0.5); 2.1717 (0.7); 2.1526 (0.3); 1.8112 (0.4); 1.7981 (0.6); 1.7865 (0.8); 1.7768 (0.7); 1.7632 (0.6); 1.7538 (0.7); 1.7423 (0.4); 1.7290 (0.3); 1.5523 (12.1); 0.0080 (0.5); 0.0006 (15.6); 0.0000 (15.6) I.1-153: 1 H-NMR (400.0 MHz, CDCl 3 ): δ= 7.2618 (32.7); 7.1138 (28.9); 6.7447 (3.0); 6.7251 (3.8); 6.6371 (2.7); 6.6333 (3.1); 6.5946 (1.9); 6.5903 (1.6); 6.5749 (1.5); 6.5706 (1.3); 5.9355 (2.7); 5.9320 (8.8); 5.9298 (9.0); 5.9262 (2.7); 5.3317 (0.6); 5.2982 (3.2); 4.7148 (1.8); 4.6773 (2.0); 4.1062 (1.8); 4.0686 (1.6); 3.9451 (0.6); 3.9348 (0.7); 3.9246 (1.1); 3.9143 (0.7); 3.9040 (0.6); 3.4499 (0.7); 3.4324 (1.2); 3.4174 (1.2); 3.4029 (1.2); 3.3883 (1.2); 3.3711 (0.7); 2.6922 (2.0); 2.6749 (4.1); 2.6576 (1.8); 2.4941 (1.4); 2.4827 (1.2); 2.4683 (0.9); 2.4582 (1.4); 2.4466 (2.1); 2.4260 (0.7); 2.4149 (0.8); 2.4006 (1.0); 2.3907 (1.1); 2.3766 (1.1); 2.3480 (0.6); 2.3338 (0.7); 2.3228 (16.0); 2.2088 (0.7); 2.1956 (0.5); 2.1847 (0.7); 2.1763 (0.8); 2.1715 (0.5); 2.1569 (0.5); 2.1520 (0.7); 2.0677 (1.5); 2.0464 (1.5); 2.0317 (1.3); 2.0104 (1.3); 1.7419 (0.6); 1.7320 (0.6); 1.7192 (0.6); 1.7087 (0.5); -0.0002 (9.8) I.1-154: 1 H-NMR (400.1 MHz, d 6 -DMSO): δ= 12.3544 (0.4); 12.3433 (0.5); 12.3055 (0.6); 12.2962 (0.7); 12.2442 (0.9); 12.2247 (0.9); 12.2081 (0.8); 12.1752 (0.7); 12.1614 (0.5); 12.1562 (0.5); 12.1320 (0.4); 12.1302 (0.4); 12.1145 (0.4); 6.8506 (0.7); 6.8417 (0.7); 6.8341 (3.0); 6.8258 (0.7); 6.8173 (0.9); 6.8114 (0.8); 6.8023 (0.7); 6.7951 (2.7); 6.7786 (0.8); 5.7931 (4.3); 5.7540 (4.1); 5.6421 (0.4); 5.6308 (0.7); 5.6202 (0.3); 5.5905 (0.8); 5.5851 (0.8); 5.5812 (1.3); 5.5770 (0.8); 5.5716 (0.9); 5.5676 (0.5); 4.8167 (1.1); 4.8029 (1.4); 4.7982 (3.0); 4.7845 (3.2); 4.7803 (3.2); 4.7667 (3.1); 4.7620 (1.6); 4.7481 (1.2); 3.5778 (1.6); 3.4591 (0.3); 3.4076 (1.8); 3.3979 (0.7); 3.3589 (1.9); 3.3063 (431.0); 3.2145 (0.8); 3.2110 (0.8); 3.1747 (0.6); 3.1631 (0.7); 3.0280 (1.6); 3.0152 (1.6); 3.0018 (3.3); 2.9976 (2.1); 2.9924 (2.2); 2.9882 (3.3); 2.7250 (1.0); 2.7135 (2.1); 2.6998 (2.4); 2.6727 (9.1); 2.6693 (3.7); 2.6644 (2.4); 2.6590 (8.2); 2.6466 (8.4); 2.6279 (7.9); 2.6056 (2.4); 2.5870 (2.5); 2.5793 (1.0); 2.5564 (2.5); 2.5510 (0.9); 2.5461 (0.5); 2.5355 (4.2); 2.5226 (4.2); 2.5177 (6.5); 2.5092 (141.5); 2.5046 (308.9); 2.5001 (435.5); 2.4955 (310.0); 2.4909 (145.8); 2.4756 (7.2); 2.4678 (2.0); 2.4547 (1.3); 2.4493 (0.8); 2.4444 (1.5); 2.4319 (1.2); 2.3913 (13.1); 2.3849 (16.0); 2.3511 (1.7); 2.3386 (1.7); 2.3318 (2.5); 2.3272 (3.7); 2.3215 (3.4); 2.3106 (1.5); 2.3072 (2.0); 2.3023 (2.0); 2.2972 (2.1); 2.2897 (2.0); 2.2840 (1.4); 2.2795 (1.5); 2.2667 (1.3); 2.0846 (0.3); 2.0710 (1.5); 1.9211 (1.4); 1.9021 (1.6); 1.8980 (2.9); 1.8897 (1.3); 1.8791 (2.8); 1.8751 (1.5); 1.8709 (1.5); 1.8666 (2.3); 1.8562 (1.2); 1.8477 (2.4); 1.8437 (1.2); 1.8248 (1.1); 1.5443 (0.6); 0.0119 (0.6); 0.0082 (2.1) I.1-155: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.2423 (0.5); 8.2285 (1.0); 8.2147 (0.5); 7.5641 (4.0); 7.3560 (0.8); 7.3402 (0.5); 7.3342 (0.8); 7.2872 (4.2); 7.2857 (4.3); 7.1856 (0.8); 7.1818 (0.8); 7.1727 (0.8); 7.1693 (0.8); 7.1654 (0.5); 7.0713 (0.8); 7.0553 (1.0); 7.0357 (0.5); 4.7306 (1.2); 4.6903 (1.4); 4.2163 (1.5); 4.1770 (1.3); 4.0842 (1.9); 4.0659 (7.0); 4.0568 (2.2); 4.0479 (7.0); 4.0437 (2.2); 4.0297 (1.9); 3.8004 (0.7); 3.7902 (0.9); 3.7804 (0.8); 3.7697 (0.5); 3.4701 (11.9); 3.1681 (0.6); 2.5323 (1.1); 2.5207 (1.6); 2.5104 (17.6); 2.5059 (39.0); 2.5012 (54.9); 2.4966 (39.0); 2.4920 (17.1); 2.3446 (0.9); 2.3235 (1.0); 2.3028 (0.7); 2.2754 (0.7); 2.2623 (0.8); 2.2514 (1.0); 2.2384 (1.0); 2.2176 (1.4); 2.2096 (0.6); 2.1961 (1.7); 2.1827 (1.1); 2.1611 (1.1); 2.1234 (0.6); 2.0995 (0.6); 2.0919 (0.8); 2.0732 (0.5); 2.0679 (0.6); 1.7485 (0.6); 1.7384 (0.6); 1.7274 (0.6); 1.7169 (0.6); 1.3358 (7.1); 1.3177 (16.0); 1.2995 (7.0); -0.0002 (2.5) I.1-156: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 7.1470 (2.1); 7.1269 (6.1); 7.1058 (6.7); 7.0854 (2.3); 5.7717 (0.9); 5.7628 (0.5); 5.7458 (1.4); 5.7288 (1.5); 5.7197 (0.6); 5.7119 (0.5); 5.7030 (1.1); 5.6863 (0.5); 5.1026 (0.6); 5.0986 (1.6); 5.0941 (1.8); 5.0901 (0.8); 5.0595 (0.6); 5.0554 (1.5); 5.0510 (2.4); 5.0483 (2.2); 5.0437 (1.5); 5.0256 (0.7); 5.0227 (1.6); 5.0202 (1.2); 5.0180 (1.3); 5.0150 (0.6); 4.6553 (1.8); 4.6171 (2.1); 4.0484 (2.3); 4.0433 (3.2); 4.0266 (6.2); 4.0102 (5.0); 3.7143 (0.7); 3.7038 (1.0); 3.6934 (1.1); 3.6831 (1.0); 3.6727 (0.8); 3.4887 (14.9); 2.7377 (1.4); 2.7276 (1.4); 2.6982 (1.8); 2.6881 (1.7); 2.5203 (0.6); 2.5116 (11.0); 2.5072 (23.2); 2.5026 (31.5); 2.4981 (22.2); 2.4936 (10.2); 2.4285 (2.0); 2.4163 (0.6); 2.4067 (1.9); 2.3893 (1.9); 2.3743 (0.9); 2.3673 (2.1); 2.3509 (0.8); 2.3079 (0.7); 2.3047 (1.1); 2.3014 (0.7); 2.2913 (2.0); 2.2879 (3.7); 2.2849 (2.9); 2.2759 (16.0); 2.2617 (1.6); 2.2549 (1.3); 2.2510 (1.0); 2.2478 (1.4); 2.2308 (0.6); 2.2197 (0.8); 2.2063 (0.8); 2.1414 (0.7); 2.1288 (0.6); 2.1229 (0.5); 2.1166 (0.6); 2.1103 (0.8); 2.1044 (0.5); 2.0909 (0.5); 2.0852 (0.6); 1.7031 (0.6); 1.6917 (0.8); 1.6807 (0.7); 1.6712 (0.7); 1.6674 (0.5); 1.6598 (0.8); -0.0002 (2.7) I.1-157: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 9.0051 (2.4); 8.6554 (0.8); 8.6356 (0.8); 7.4178 (2.3); 7.1407 (1.9); 7.1208 (4.2); 7.0920 (4.5); 7.0717 (1.9); 4.6444 (1.2); 4.6060 (1.7); 4.5919 (0.6); 4.5822 (0.5); 3.9486 (1.3); 3.9107 (1.2); 3.6437 (0.7); 3.6273 (16.0); 3.6125 (0.6); 3.4337 (16.8); 3.1854 (0.5); 3.1677 (2.3); 3.1520 (0.6); 3.1280 (1.0); 3.1148 (0.9); 3.0484 (0.9); 3.0244 (0.9); 3.0107 (0.6); 2.9871 (0.6); 2.6697 (0.5); 2.5185 (2.2); 2.5098 (30.0); 2.5053 (63.5); 2.5006 (88.5); 2.4960 (61.1); 2.4914 (27.4); 2.4766 (1.2); 2.3368 (0.5); 2.3274 (0.6); 2.3180 (0.9); 2.2959 (0.8); 2.2752 (11.0); 2.2456 (0.6); 2.2325 (0.6); 2.2217 (0.8); 2.2071 (1.3); 2.1838 (1.0); 2.1719 (0.8); 2.1666 (0.6); 2.1494 (0.7); 1.9521 (0.6); 0.0080 (0.6); -0.0002 (19.6); -0.0086 (0.6) I.1-158: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.2324 (0.9); 7.2136 (2.2); 7.1949 (1.4); 7.0826 (1.2); 7.0636 (0.9); 7.0296 (2.0); 7.0167 (1.2); 6.9969 (1.0); 4.6859 (1.3); 4.6476 (1.5); 4.0476 (1.5); 4.0093 (1.4); 3.9639 (0.8); 3.7124 (0.6); 3.7022 (0.8); 3.6927 (0.8); 3.6894 (0.8); 3.6798 (0.8); 3.6698 (0.7); 3.5535 (0.6); 3.1693 (16.0); 2.6925 (1.1); 2.6829 (1.1); 2.6529 (1.3); 2.6433 (1.3); 2.5107 (3.4); 2.5061 (7.3); 2.5015 (10.1); 2.4969 (7.0); 2.4923 (3.1); 2.4031 (0.8); 2.3848 (0.6); 2.3798 (0.6); 2.3616 (0.6); 2.3214 (1.5); 2.2981 (2.1); 2.2857 (11.3); 2.2733 (1.1); 2.2589 (1.9); 2.2315 (0.6); 2.2183 (0.6); 2.1654 (0.5); 2.1344 (0.6); 1.7095 (0.6); 1.6777 (0.6); - 0.0002 (2.4) I.1-159: 1 H-NMR (400.1 MHz, d6-DMSO): δ= 7.4065 (2.2); 7.3908 (3.0); 7.3865 (4.4); 7.3713 (4.6); 7.3672 (3.6); 7.3515 (3.1); 7.2071 (4.4); 7.1160 (2.1); 7.1099 (2.5); 7.0934 (3.8); 7.0883 (4.5); 7.0755 (16.0); 7.0681 (3.1); 7.0571 (9.2); 7.0314 (3.3); 7.0273 (3.8); 6.9439 (4.6); 4.6331 (5.9); 4.5938 (6.9); 4.1675 (6.9); 4.1283 (5.9); 3.8352 (0.9); 3.8247 (2.0); 3.8141 (2.8); 3.8038 (3.2); 3.7935 (2.9); 3.7831 (2.2); 3.7726 (1.1); 2.8262 (3.7); 2.8159 (3.8); 2.7867 (4.6); 2.7764 (4.6); 2.6698 (0.3); 2.5232 (0.4); 2.5185 (0.7); 2.5098 (18.0); 2.5053 (40.8); 2.5007 (58.1); 2.4961 (43.1); 2.4917 (21.1); 2.4749 (5.0); 2.4526 (4.9); 2.4353 (4.1); 2.4248 (1.8); 2.4131 (4.0); 2.4067 (3.8); 2.3880 (2.9); 2.3836 (2.8); 2.3650 (2.5); 2.3322 (0.3); 2.3276 (0.5); 2.3189 (2.3); 2.3055 (2.6); 2.2946 (3.5); 2.2813 (3.5); 2.2641 (1.1); 2.2528 (2.0); 2.2401 (2.2); 2.2128 (1.4); 2.1940 (2.2); 2.1891 (1.3); 2.1815 (1.7); 2.1751 (1.5); 2.1698 (1.8); 2.1626 (2.6); 2.1577 (1.7); 2.1510 (1.1); 2.1431 (1.6); 2.1383 (1.9); 2.1191 (0.9); 2.0710 (0.7); 1.7437 (1.1); 1.7320 (1.8); 1.7205 (2.4); 1.7097 (2.1); 1.7003 (2.2); 1.6888 (2.2); 1.6774 (1.5); 1.6647 (1.0); 0.0082 (0.4) I.1-160: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 7.9248 (0.5); 7.9177 (4.2); 7.9129 (1.3); 7.9005 (1.3); 7.8955 (4.4); 7.1255 (1.3); 7.1049 (5.4); 7.0924 (5.8); 7.0718 (1.4); 7.0558 (0.5); 7.0487 (4.2); 7.0438 (1.3); 7.0314 (1.2); 7.0265 (4.0); 4.6448 (1.4); 4.6067 (1.6); 4.3549 (0.8); 4.3446 (2.0); 4.3352 (2.1); 4.3260 (1.1); 4.2461 (2.2); 4.2353 (2.8); 4.2243 (1.4); 4.0467 (1.6); 4.0083 (1.4); 3.8143 (16.0); 3.7137 (0.7); 3.7034 (0.8); 3.6930 (0.7); 3.6829 (0.5); 3.3260 (190.0); 2.7839 (0.9); 2.7738 (1.0); 2.7442 (1.2); 2.7340 (1.2); 2.5102 (25.0); 2.5058 (52.5); 2.5013 (71.9); 2.4968 (51.1); 2.4925 (23.7); 2.4832 (1.9); 2.4612 (1.3); 2.4432 (1.1); 2.4213 (1.1); 2.3840 (0.8); 2.3665 (0.6); 2.3611 (0.6); 2.3431 (0.6); 2.2587 (11.3); 2.2440 (0.9); 2.2302 (0.9); 2.2023 (0.5); 2.1889 (0.5); 2.1325 (0.5); 2.1013 (0.6); 1.7010 (0.6); 1.6900 (0.5); 1.6808 (0.5); 1.6689 (0.5); -0.0002 (1.7) I.1-161: 1 H-NMR (400.1 MHz, d6-DMSO): δ= 11.7696 (3.0); 7.3869 (0.4); 7.3831 (0.4); 7.3665 (0.8); 7.3625 (0.9); 7.3565 (0.5); 7.3468 (0.6); 7.3406 (0.9); 7.3365 (0.8); 7.3202 (0.5); 7.3164 (0.5); 7.2145 (0.5); 7.2108 (0.6); 7.2017 (0.5); 7.1979 (0.7); 7.1945 (1.0); 7.1910 (1.0); 7.1818 (0.9); 7.1785 (1.0); 7.1745 (0.6); 7.1705 (0.6); 7.1615 (0.6); 7.1581 (0.6); 7.0835 (1.0); 7.0674 (1.3); 7.0643 (1.3); 7.0480 (0.7); 4.7358 (1.5); 4.6962 (1.8); 4.2472 (1.9); 4.2073 (1.6); 3.8457 (0.6); 3.8353 (0.9); 3.8250 (1.0); 3.8148 (0.9); 3.8047 (0.6); 3.3984 (16.0); 3.3400 (0.4); 3.1687 (6.8); 2.9508 (0.4); 2.9367 (1.0); 2.9344 (0.8); 2.9261 (0.6); 2.9187 (1.7); 2.9129 (0.6); 2.9067 (0.7); 2.9026 (1.0); 2.8996 (0.6); 2.8871 (0.5); 2.7563 (1.3); 2.7458 (1.3); 2.7184 (1.6); 2.7080 (1.6); 2.6698 (0.4); 2.5401 (0.5); 2.5233 (0.8); 2.5185 (1.2); 2.5099 (19.4); 2.5053 (42.5); 2.5007 (59.8); 2.4961 (43.2); 2.4915 (20.3); 2.4465 (1.9); 2.4249 (2.1); 2.4087 (1.6); 2.4033 (1.2); 2.3866 (1.9); 2.3627 (0.7); 2.3277 (0.4); 2.3030 (0.7); 2.2908 (0.8); 2.2788 (1.2); 2.2667 (1.2); 2.2616 (0.5); 2.2371 (0.8); 2.2252 (1.0); 2.2067 (0.8); 2.1950 (0.6); 2.1877 (0.5); 2.1825 (0.5); 2.1758 (1.0); 2.1712 (0.5); 2.1560 (0.5); 2.1516 (0.6); 2.0721 (0.4); 1.7893 (0.4); 1.7803 (0.7); 1.7687 (0.7); 1.7587 (0.8); 1.7504 (0.8); 1.7467 (0.5); 1.7388 (0.6); 1.7259 (0.5); 1.0795 (0.9); 1.0683 (8.4); 1.0642 (3.5); 1.0541 (3.5); 1.0497 (4.4); 1.0447 (2.3) I.1-162: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 11.8115 (2.9); 7.0842 (0.8); 7.0665 (1.7); 7.0473 (1.1); 6.9675 (1.1); 6.9643 (1.2); 6.9471 (1.8); 6.9303 (0.8); 6.9271 (0.8); 4.6937 (1.8); 4.6542 (2.1); 4.1785 (2.3); 4.1391 (2.0); 3.9644 (0.9); 3.8139 (0.8); 3.8034 (1.1); 3.7929 (1.3); 3.7827 (1.1); 3.7725 (0.8); 3.4807 (16.0); 3.2125 (36.5); 3.1689 (6.1); 2.7366 (1.7); 2.7262 (1.8); 2.6983 (2.2); 2.6879 (2.0); 2.5236 (1.2); 2.5189 (1.6); 2.5103 (22.0); 2.5057 (46.8); 2.5010 (64.2); 2.4964 (44.9); 2.4918 (20.1); 2.4242 (2.3); 2.4022 (2.7); 2.3858 (3.0); 2.3640 (2.8); 2.3434 (1.0); 2.2892 (1.0); 2.2767 (1.3); 2.2622 (10.2); 2.2575 (10.0); 2.2232 (0.9); 2.2118 (1.0); 2.1982 (0.7); 2.1795 (1.0); 2.1676 (0.7); 2.1603 (0.6); 2.1554 (0.7); 2.1482 (1.2); 2.1435 (0.6); 2.1284 (0.6); 2.1239 (0.8); 1.7645 (0.8); 1.7533 (0.9); 1.7430 (0.9); 1.7336 (1.0); 1.7222 (0.8); 1.7105 (0.6); -0.0002 (8.7) I.1-163: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 7.5739 (0.6); 7.5701 (0.6); 7.5538 (0.7); 7.5501 (0.6); 7.3639 (0.7); 7.3443 (1.3); 7.3245 (0.8); 7.2132 (0.6); 7.2095 (0.6); 4.6726 (0.6); 4.6315 (0.7); 4.2824 (0.7); 4.2412 (0.5); 3.5781 (16.0); 3.1684 (0.7); 2.5307 (0.6); 2.5233 (0.8); 2.5186 (1.2); 2.5100 (16.6); 2.5054 (35.6); 2.5008 (48.4); 2.4961 (33.4); 2.4915 (15.0); 2.2233 (0.8); 2.2011 (0.5); 2.1868 (0.5); -0.0002 (3.0) I.1-164: 1 H-NMR (400.1 MHz, d6-DMSO): δ= 11.4616 (1.0); 7.4066 (0.5); 7.3796 (0.5); 4.6068 (0.5); 4.5678 (0.6); 4.1463 (0.7); 4.1072 (0.6); 3.7859 (0.3); 3.4370 (1.1); 2.7761 (16.0); 2.7187 (0.4); 2.7082 (0.4); 2.6809 (0.5); 2.6704 (0.5); 2.5102 (2.0); 2.5057 (4.4); 2.5011 (6.2); 2.4965 (4.6); 2.4921 (2.2); 2.3880 (0.4); 2.3638 (0.7); 2.3416 (0.5); 2.3259 (0.4); 2.3035 (0.5); 2.2907 (0.4); 2.2770 (0.4) I.1-166: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 11.8114 (5.2); 7.3902 (2.4); 7.3711 (6.4); 7.3531 (7.1); 7.3520 (7.4); 7.3458 (3.5); 7.3416 (6.2); 7.3369 (5.0); 7.3259 (1.3); 7.3207 (2.2); 7.3169 (1.5); 7.2910 (4.4); 7.2868 (6.8); 7.2833 (3.8); 7.2019 (2.7); 7.1980 (4.8); 7.1943 (2.6); 7.1840 (2.2); 7.1799 (3.8); 7.1762 (2.1); 4.6368 (4.2); 4.5976 (4.9); 4.1406 (4.8); 4.1013 (4.2); 3.9643 (0.8); 3.8345 (0.7); 3.8238 (1.5); 3.8131 (2.1); 3.8027 (2.4); 3.7929 (2.1); 3.7823 (1.6); 3.7718 (0.7); 3.3904 (46.2); 3.3395 (0.8); 3.2658 (0.6); 3.2163 (64.1); 3.1683 (16.0); 3.1657 (0.5); 2.7425 (3.1); 2.7317 (3.2); 2.7042 (3.8); 2.6934 (3.6); 2.6743 (0.8); 2.6696 (1.1); 2.6650 (0.8); 2.5546 (0.6); 2.5500 (1.1); 2.5453 (1.1); 2.5399 (1.3); 2.5337 (0.8); 2.5288 (1.0); 2.5232 (2.7); 2.5184 (3.8); 2.5098 (58.7); 2.5052 (126.6); 2.5005 (175.4); 2.4959 (123.5); 2.4913 (55.9); 2.4398 (1.1); 2.4217 (1.2); 2.4174 (1.2); 2.3985 (2.7); 2.3911 (4.1); 2.3797 (2.3); 2.3755 (2.3); 2.3692 (4.1); 2.3529 (3.8); 2.3310 (3.7); 2.3275 (1.7); 2.3195 (2.0); 2.3063 (2.2); 2.2954 (2.8); 2.2822 (2.7); 2.2779 (1.2); 2.2646 (0.9); 2.2535 (1.5); 2.2407 (1.5); 2.2020 (1.1); 2.1829 (1.7); 2.1781 (1.0); 2.1704 (1.3); 2.1637 (1.1); 2.1587 (1.4); 2.1512 (2.0); 2.1464 (1.2); 2.1397 (0.8); 2.1318 (1.2); 2.1270 (1.4); 2.1076 (0.7); 2.0718 (0.6); 1.7645 (0.9); 1.7521 (1.3); 1.7412 (1.8); 1.7308 (1.5); 1.7202 (1.5); 1.7093 (1.7); 1.6984 (1.0); 1.6855 (0.7); 0.0080 (1.0); 0.0039 (0.5); -0.0002 (33.7); -0.0085 (0.9) I.1-167: 1 H-NMR (400.1 MHz, CDCl 3 ): δ= 7.5256 (1.1); 7.5194 (1.5); 7.3143 (2.5); 7.3089 (3.2); 7.2934 (6.3); 7.2902 (6.1); 7.2867 (6.1); 7.2669 (203.6); 7.2605 (281.8); 7.1667 (0.4); 7.1020 (0.4); 7.0381 (9.3); 7.0190 (8.2); 7.0029 (1.8); 6.9965 (2.7); 6.9796 (8.3); 6.9684 (11.6); 6.9638 (13.0); 6.9452 (11.2); 6.9238 (0.7); 5.5276 (1.0); 5.4726 (0.3); 5.4107 (4.8); 4.8360 (0.7); 4.7972 (0.7); 4.6733 (8.2); 4.6348 (9.8); 4.4463 (0.4); 4.3584 (1.6); 4.3209 (1.4); 4.2687 (9.5); 4.2308 (7.9); 4.1390 (0.8); 4.1009 (1.4); 4.0830 (0.7); 4.0731 (0.6); 4.0535 (1.6); 4.0396 (3.8); 4.0336 (4.0); 4.0266 (4.6); 4.0212 (5.6); 4.0142 (3.7); 4.0086 (4.2); 4.0018 (2.7); 3.9895 (1.4); 3.9167 (0.3); 3.9098 (0.4); 3.8912 (0.5); 3.8801 (0.4); 3.8699 (0.4); 3.8075 (0.6); 3.6642 (0.4); 3.6540 (4.5); 3.6479 (6.4); 3.4915 (0.3); 2.7359 (0.7); 2.7231 (0.8); 2.6940 (1.1); 2.6812 (1.9); 2.6695 (3.0); 2.6626 (4.3); 2.6533 (5.5); 2.6454 (5.3); 2.6362 (4.1); 2.6183 (0.8); 2.6022 (0.6); 2.5912 (0.8); 2.5660 (0.6); 2.5518 (1.6); 2.5331 (2.9); 2.5092 (5.2); 2.4905 (7.0); 2.4676 (4.8); 2.4604 (3.7); 2.4543 (5.9); 2.4456 (9.3); 2.4370 (7.9); 2.4322 (9.8); 2.4216 (4.8); 2.4157 (9.1); 2.4090 (8.1); 2.4016 (6.2); 2.3960 (7.9); 2.3879 (4.0); 2.3787 (2.3); 2.3733 (3.1); 2.3668 (1.5); 2.3612 (1.3); 2.3486 (1.8); 2.3336 (1.4); 2.3222 (2.4); 2.3172 (2.7); 2.2982 (4.4); 2.2933 (2.3); 2.2846 (3.6); 2.2795 (3.5); 2.2735 (3.5); 2.2659 (4.9); 2.2609 (3.0); 2.2466 (3.9); 2.2419 (3.0); 2.2223 (1.4); 2.1081 (4.6); 2.1027 (6.3); 2.0884 (4.7); 2.0828 (6.3); 2.0715 (4.1); 2.0660 (5.3); 2.0516 (3.8); 2.0462 (5.0); 2.0043 (0.3); 1.9404 (0.6); 1.8544 (0.4); 1.8152 (2.2); 1.8045 (3.2); 1.7956 (3.0); 1.7912 (3.8); 1.7830 (4.4); 1.7773 (3.7); 1.7716 (4.1); 1.7595 (2.8); 1.7482 (2.6); 1.7393 (1.4); 1.7337 (1.6); 1.5655 (56.0); 1.5603 (72.9); 1.2583 (0.7); 0.9113 (0.6); 0.8952 (0.6); 0.8835 (0.7); 0.7904 (2.6); 0.7843 (4.3); 0.7725 (12.4); 0.7681 (12.4); 0.7559 (14.5); 0.7453 (5.5); 0.7376 (4.7); 0.7202 (1.3); 0.7139 (1.1); 0.7071 (1.0); 0.6818 (0.5); 0.6642 (0.8); 0.6565 (0.7); 0.5201 (0.8); 0.4989 (1.4); 0.4940 (1.2); 0.4878 (1.2); 0.4680 (0.6); 0.4569 (3.0); 0.4389 (16.0); 0.4355 (16.0); 0.4292 (15.1); 0.4131 (3.8); 0.4028 (1.1); 0.1458 (0.4); 0.0144 (1.8); 0.0063 (68.5); 0.0000 (97.2) I.1-168: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 3.3340 (1.0); 3.1172 (1.3); 3.0788 (1.8); 3.0606 (5.7); 3.0423 (5.9); 3.0242 (1.8); 2.9097 (1.5); 2.6735 (1.5); 2.5250 (0.6); 2.5204 (0.8); 2.5117 (7.4); 2.5071 (15.4); 2.5026 (20.8); 2.4980 (14.4); 2.4934 (6.2); 1.2051 (7.6); 1.1869 (16.0); 1.1687 (7.3); 0.9789 (0.8); -0.0002 (5.5) I.1-169: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 12.5442 (1.2); 8.2871 (1.5); 8.2668 (1.6); 7.2211 (2.1); 7.2072 (7.0); 7.1951 (1.8); 7.1769 (1.3); 7.1695 (1.3); 7.1583 (2.0); 7.1510 (1.9); 7.1369 (1.4); 7.1168 (2.4); 7.0962 (1.2); 4.7616 (2.3); 4.7224 (2.5); 4.3034 (1.0); 4.2520 (0.8); 4.2361 (1.0); 4.0907 (2.1); 4.0511 (1.9); 3.6863 (1.1); 3.3130 (142.7); 2.6743 (2.4); 2.6697 (2.9); 2.6653 (2.1); 2.6251 (1.6); 2.6087 (3.7); 2.5897 (3.9); 2.5722 (1.8); 2.5400 (3.0); 2.5232 (8.3); 2.5185 (12.1); 2.5098 (184.3); 2.5053 (404.0); 2.5007 (565.0); 2.4960 (393.6); 2.4915 (174.3); 2.4089 (1.1); 2.3875 (1.0); 2.3683 (1.4); 2.3321 (2.5); 2.3275 (3.3); 2.3226 (2.2); 2.2909 (1.8); 2.2690 (1.8); 2.2571 (2.0); 2.2345 (1.4); 2.0851 (1.0); 2.0731 (1.2); 2.0421 (0.9); 2.0123 (0.9); 1.7541 (1.0); 1.6073 (0.9); 1.5010 (2.1); 1.4874 (2.4); 1.4656 (1.4); 1.1746 (1.4); 1.1557 (3.0); 1.1419 (7.1); 1.1231 (16.0); 1.1042 (6.9); 0.8911 (9.6); 0.8747 (9.5); 0.8230 (9.9); 0.8068 (9.5); 0.0080 (6.4); -0.0002 (256.0); -0.0086 (7.9); -0.1496 (0.9) I.1-170: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 6.9334 (0.9); 6.9132 (3.3); 6.8971 (3.6); 6.8918 (0.7); 6.8766 (1.0); 4.4483 (0.9); 4.4101 (1.0); 3.8478 (1.1); 3.8096 (0.9); 3.6126 (1.7); 3.6080 (1.8); 3.5942 (1.8); 3.5899 (1.8); 3.5044 (0.5); 3.4941 (0.6); 3.4839 (0.5); 3.2408 (8.9); 2.5391 (0.7); 2.5288 (0.7); 2.4996 (0.9); 2.4893 (0.9); 2.2962 (5.6); 2.2917 (11.8); 2.2871 (16.0); 2.2825 (11.2); 2.2780 (5.1); 2.2355 (1.0); 2.2138 (1.1); 2.1960 (0.8); 2.1915 (0.6); 2.1742 (1.1); 2.0607 (7.5); 2.0522 (0.9); 2.0383 (0.6); 0.8135 (0.6); 0.2847 (1.4); 0.2801 (1.5); 0.2754 (0.6); 0.2697 (0.6); 0.2644 (1.5); 0.2600 (1.4); 0.2497 (0.5); 0.0261 (0.6); 0.0155 (1.6); 0.0116 (1.5); 0.0038 (1.4); -0.0002 (1.7); -0.2157 (1.5) I.1-171: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 11.8025 (3.0); 7.4101 (0.8); 7.4037 (7.4); 7.3987 (2.3); 7.3875 (2.7); 7.3824 (10.0); 7.3761 (1.1); 7.2665 (1.0); 7.2603 (7.5); 7.2552 (2.2); 7.2438 (1.9); 7.2389 (5.5); 7.2325 (0.6); 4.6235 (2.5); 4.5845 (2.9); 4.1260 (2.8); 4.0871 (2.4); 3.8018 (0.9); 3.7912 (1.2); 3.7810 (1.4); 3.7710 (1.2); 3.7605 (0.9); 3.4435 (9.0); 3.3856 (0.7); 3.2134 (36.0); 3.1682 (16.0); 2.7214 (1.8); 2.7104 (1.8); 2.6830 (2.2); 2.6721 (2.3); 2.6651 (0.5); 2.5398 (0.5); 2.5341 (0.6); 2.5297 (0.8); 2.5232 (1.6); 2.5184 (2.1); 2.5098 (32.4); 2.5052 (69.0); 2.5006 (94.5); 2.4959 (65.7); 2.4913 (29.5); 2.4142 (0.6); 2.4095 (0.6); 2.3909 (1.5); 2.3773 (2.4); 2.3725 (1.5); 2.3683 (1.2); 2.3556 (2.3); 2.3492 (1.2); 2.3391 (1.9); 2.3321 (0.6); 2.3273 (0.7); 2.3225 (0.6); 2.3174 (1.9); 2.3021 (1.0); 2.2889 (1.2); 2.2779 (1.6); 2.2647 (1.5); 2.2604 (0.7); 2.2474 (0.5); 2.2360 (0.9); 2.2233 (0.9); 2.1854 (0.6); 2.1663 (1.0); 2.1615 (0.5); 2.1539 (0.8); 2.1472 (0.6); 2.1421 (0.8); 2.1347 (1.2); 2.1298 (0.7); 2.1152 (0.7); 2.1104 (0.8); 1.7521 (0.5); 1.7399 (0.8); 1.7289 (1.0); 1.7184 (0.9); 1.7080 (0.9); 1.6970 (1.0); 1.6861 (0.6); -0.0002 (9.2) I.1-174: 1 H-NMR (400.1 MHz, d6-DMSO): δ= 11.8034 (1.4); 7.4084 (0.5); 7.3928 (0.6); 7.3885 (1.0); 7.3733 (1.0); 7.3691 (0.8); 7.3535 (0.7); 7.1181 (0.4); 7.1114 (0.5); 7.0958 (0.8); 7.0901 (0.9); 7.0767 (1.6); 7.0562 (1.7); 7.0300 (0.7); 7.0254 (0.8); 4.6518 (1.3); 4.6125 (1.5); 4.1514 (1.5); 4.1122 (1.3); 3.8286 (0.4); 3.8182 (0.6); 3.8077 (0.8); 3.7975 (0.6); 3.7875 (0.5); 3.3880 (0.4); 3.3380 (84.3); 3.2887 (0.5); 3.2119 (16.0); 2.7363 (0.9); 2.7254 (0.9); 2.6980 (1.1); 2.6871 (1.1); 2.5240 (0.5); 2.5192 (0.6); 2.5106 (12.5); 2.5060 (27.9); 2.5015 (39.4); 2.4969 (28.4); 2.4923 (13.3); 2.4215 (0.4); 2.4175 (0.4); 2.3961 (1.4); 2.3743 (1.5); 2.3575 (1.5); 2.3358 (1.0); 2.3284 (0.3); 2.3216 (0.6); 2.3082 (0.6); 2.2973 (0.8); 2.2842 (0.8); 2.2555 (0.4); 2.2427 (0.4); 2.2093 (0.3); 2.1904 (0.5); 2.1781 (0.4); 2.1712 (0.3); 2.1663 (0.4); 2.1589 (0.6); 2.1539 (0.4); 2.1395 (0.4); 2.1347 (0.4); 1.7537 (0.4); 1.7424 (0.5); 1.7323 (0.5); 1.7218 (0.5); 1.7107 (0.5) I.1-175: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 9.7756 (2.3); 7.4771 (3.8); 7.4546 (3.9); 7.1315 (1.7); 7.1110 (6.6); 7.0979 (7.0); 7.0772 (1.6); 6.8600 (4.4); 6.8375 (4.1); 4.6493 (1.7); 4.6110 (1.9); 4.3084 (1.0); 4.2978 (2.6); 4.2867 (2.8); 4.2767 (1.2); 4.0989 (2.3); 4.0877 (3.7); 4.0763 (1.8); 4.0517 (2.0); 4.0137 (1.8); 3.7263 (0.6); 3.7162 (0.9); 3.7055 (1.1); 3.6957 (1.0); 3.6852 (0.7); 3.3670 (112.0); 3.1677 (0.8); 2.7819 (1.1); 2.7718 (1.2); 2.7422 (1.5); 2.7321 (1.4); 2.5100 (32.8); 2.5058 (67.4); 2.5014 (91.0); 2.4969 (64.3); 2.4764 (1.7); 2.4544 (1.5); 2.4364 (1.4); 2.4147 (1.7); 2.3910 (1.1); 2.3726 (0.8); 2.3674 (0.8); 2.3494 (0.7); 2.3284 (0.6); 2.2644 (13.8); 2.2481 (1.1); 2.2345 (1.1); 2.2062 (0.6); 2.1933 (0.7); 2.1556 (0.5); 2.1369 (0.6); 2.1241 (0.5); 2.1058 (0.8); 2.0812 (0.5); 1.9988 (16.0); 1.7158 (0.5); 1.7042 (0.7); 1.6934 (0.6); 1.6839 (0.7); 1.6723 (0.6); - 0.0002 (2.1) I.1-177: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.6552 (3.3); 8.6402 (6.1); 8.6239 (3.2); 7.3799 (2.4); 7.3761 (2.5); 7.3557 (5.5); 7.3340 (5.4); 7.3132 (2.9); 7.3094 (2.8); 7.2088 (3.2); 7.2047 (3.4); 7.1959 (3.3); 7.1887 (5.8); 7.1849 (6.2); 7.1761 (5.7); 7.1724 (6.2); 7.1685 (4.0); 7.1644 (3.7); 7.1556 (3.2); 7.1518 (3.4); 7.0798 (5.6); 7.0637 (7.7); 7.0444 (4.1); 4.7384 (8.9); 4.6989 (10.4); 4.2375 (11.5); 4.1977 (9.9); 3.9285 (2.6); 3.9067 (7.8); 3.9038 (7.8); 3.8879 (8.0); 3.8821 (8.2); 3.8790 (7.8); 3.8660 (7.6); 3.8631 (7.8); 3.8575 (3.4); 3.8383 (3.1); 3.8231 (4.0); 3.8123 (5.5); 3.8022 (6.9); 3.7921 (5.5); 3.7816 (3.9); 3.7713 (1.9); 3.3577 (1.2); 3.3081 (337.7); 3.2588 (2.5); 3.1685 (0.8); 2.6741 (2.9); 2.6693 (4.1); 2.6647 (2.8); 2.6377 (8.4); 2.6265 (8.6); 2.6022 (10.6); 2.5910 (10.0); 2.5502 (1.9); 2.5395 (2.6); 2.5228 (9.6); 2.5181 (13.9); 2.5095 (229.2); 2.5049 (503.0); 2.5002 (704.9); 2.4956 (486.0); 2.4910 (215.3); 2.4552 (3.4); 2.4504 (4.5); 2.4458 (3.2); 2.4106 (2.3); 2.3909 (3.2); 2.3686 (6.6); 2.3490 (6.2); 2.3315 (4.3); 2.3248 (15.4); 2.3027 (10.6); 2.2892 (11.2); 2.2776 (6.7); 2.2669 (16.0); 2.2535 (7.9); 2.2359 (2.9); 2.2248 (4.3); 2.2119 (4.1); 2.1591 (2.8); 2.1397 (4.8); 2.1352 (2.9); 2.1273 (3.5); 2.1203 (3.0); 2.1157 (4.2); 2.1080 (5.7); 2.1036 (3.3); 2.0966 (2.1); 2.0884 (3.2); 2.0839 (4.3); 2.0644 (2.0); 1.7623 (2.3); 1.7499 (3.5); 1.7388 (4.7); 1.7282 (4.0); 1.7174 (4.0); 1.7071 (4.0); 1.6961 (2.6); 1.6834 (1.7); 0.0081 (1.7); -0.0002 (63.7); -0.0085 (1.7) I.1-178: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.0421 (3.8); 7.3784 (1.6); 7.3745 (1.7); 7.3583 (3.3); 7.3541 (3.6); 7.3481 (1.9); 7.3382 (2.2); 7.3319 (3.5); 7.3119 (1.9); 7.3081 (1.9); 7.2073 (2.1); 7.2033 (2.2); 7.1945 (2.1); 7.1875 (3.8); 7.1837 (4.0); 7.1747 (3.7); 7.1710 (4.1); 7.1672 (2.5); 7.1630 (2.4); 7.1543 (2.1); 7.1505 (2.3); 7.1265 (0.6); 7.1158 (0.8); 7.0740 (3.9); 7.0580 (5.2); 7.0385 (2.8); 4.7382 (6.0); 4.6989 (6.8); 4.2292 (7.5); 4.1894 (6.5); 3.8099 (1.2); 3.7986 (2.3); 3.7885 (3.6); 3.7783 (4.6); 3.7680 (3.6); 3.7582 (2.4); 3.7472 (1.3); 3.3987 (1.0); 3.3669 (1.3); 3.3169 (338.3); 3.3009 (29.3); 3.2875 (18.9); 3.2756 (1.7); 3.2691 (2.6); 3.2657 (2.4); 3.2524 (0.6); 3.2252 (183.9); 3.1996 (6.6); 3.1858 (16.0); 3.1718 (13.6); 3.1572 (4.0); 3.0471 (1.0); 2.6743 (1.6); 2.6696 (2.5); 2.6651 (1.6); 2.5505 (0.9); 2.5400 (1.5); 2.5231 (10.3); 2.5185 (8.7); 2.5098 (139.7); 2.5052 (300.9); 2.5006 (423.9); 2.4960 (294.5); 2.4914 (131.5); 2.4765 (8.2); 2.4558 (2.3); 2.4513 (2.8); 2.4467 (2.0); 2.4045 (1.7); 2.3815 (2.1); 2.3618 (4.4); 2.3420 (4.1); 2.3320 (2.2); 2.3274 (2.9); 2.3191 (3.9); 2.2787 (4.3); 2.2658 (4.3); 2.2547 (5.3); 2.2417 (5.2); 2.2371 (2.4); 2.2242 (8.8); 2.2128 (3.2); 2.2029 (7.6); 2.1894 (5.9); 2.1682 (5.6); 2.1407 (2.0); 2.1212 (3.3); 2.1168 (2.0); 2.1091 (2.3); 2.1019 (2.0); 2.0973 (2.9); 2.0896 (4.0); 2.0851 (2.4); 2.0775 (1.4); 2.0700 (2.2); 2.0654 (3.0); 2.0458 (1.3); 1.7752 (1.6); 1.7628 (2.4); 1.7520 (3.3); 1.7417 (2.8); 1.7308 (2.7); 1.7204 (3.0); 1.7095 (1.8); 1.6966 (1.3); 0.0080 (0.8); -0.0002 (33.1); -0.0086 (0.9) I.1-179: 1 H-NMR (400.1 MHz, d 6 -DMSO): δ= 6.8483 (0.6); 6.8401 (0.6); 6.8321 (2.3); 6.8242 (0.7); 6.8158 (0.7); 6.8096 (0.7); 6.7932 (2.1); 6.7868 (0.7); 6.7766 (0.7); 5.7925 (3.6); 5.7539 (3.4); 5.6221 (0.3); 5.5896 (0.8); 5.5842 (1.0); 5.5797 (1.4); 5.5763 (1.0); 5.5704 (0.9); 3.4324 (0.8); 3.3076 (12.1); 3.1691 (1.1); 2.9993 (3.5); 2.9952 (2.6); 2.9898 (3.0); 2.9861 (3.3); 2.6740 (0.7); 2.6695 (0.9); 2.6653 (0.8); 2.6481 (0.4); 2.6405 (0.4); 2.6223 (0.4); 2.6060 (0.8); 2.6017 (0.7); 2.5578 (0.3); 2.5532 (0.3); 2.5332 (0.3); 2.5228 (1.8); 2.5094 (52.8); 2.5050 (109.3); 2.5006 (147.2); 2.4962 (105.1); 2.4919 (49.5); 2.4583 (0.4); 2.4536 (0.4); 2.4489 (0.3); 2.3902 (11.6); 2.3836 (16.0); 2.3321 (0.7); 2.3275 (0.9); 2.3227 (0.7); 2.3187 (0.4); 0.0081 (0.8); 0.0010 (20.4); 0.0000 (20.9) I.1-180: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.4095 (4.9); 7.3744 (2.0); 7.3575 (4.0); 7.3538 (4.5); 7.3317 (4.4); 7.3112 (2.4); 7.2076 (2.6); 7.2037 (2.6); 7.1949 (2.6); 7.1877 (4.6); 7.1840 (5.0); 7.1750 (4.5); 7.1715 (4.9); 7.1673 (3.0); 7.1634 (2.9); 7.1546 (2.7); 7.1510 (2.8); 7.0804 (4.6); 7.0644 (6.4); 7.0449 (3.4); 4.7434 (7.4); 4.7041 (8.4); 4.2213 (9.2); 4.1818 (8.0); 3.8383 (15.1); 3.8320 (15.9); 3.8243 (16.0); 3.8181 (14.8); 3.8006 (3.0); 3.7903 (4.6); 3.7802 (5.6); 3.7698 (4.5); 3.7597 (3.0); 3.7490 (1.6); 3.4184 (0.8); 3.3165 (259.7); 3.2688 (2.2); 3.2161 (0.6); 3.1685 (3.5); 3.0919 (11.4); 2.6741 (1.9); 2.6695 (2.8); 2.6646 (2.0); 2.5476 (7.1); 2.5361 (7.4); 2.5229 (6.9); 2.5182 (10.8); 2.5096 (165.2); 2.5050 (354.4); 2.5003 (499.5); 2.4957 (342.2); 2.4911 (152.5); 2.4552 (2.5); 2.4508 (3.1); 2.4091 (2.2); 2.3865 (2.6); 2.3663 (5.4); 2.3464 (5.1); 2.3364 (1.6); 2.3319 (2.5); 2.3229 (5.6); 2.2790 (4.1); 2.2663 (5.0); 2.2549 (6.4); 2.2422 (6.4); 2.2353 (9.2); 2.2246 (2.7); 2.2135 (11.0); 2.2003 (10.0); 2.1786 (6.6); 2.1487 (2.4); 2.1292 (4.1); 2.1171 (2.9); 2.1098 (2.4); 2.1053 (3.4); 2.0977 (4.7); 2.0932 (2.7); 2.0856 (1.7); 2.0778 (2.7); 2.0735 (3.8); 2.0536 (1.5); 1.7651 (1.9); 1.7534 (2.9); 1.7422 (3.6); 1.7318 (3.5); 1.7206 (3.3); 1.7104 (3.3); 1.6990 (2.2); 1.6872 (1.5); 0.0080 (1.3); -0.0002 (45.0); -0.0085 (1.4) I.1-181: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.3390 (0.7); 8.3253 (1.3); 8.3110 (0.7); 7.3583 (1.0); 7.3357 (1.0); 7.3156 (0.6); 7.2061 (1.8); 7.2014 (2.0); 7.1897 (5.0); 7.1870 (7.1); 7.1838 (4.8); 7.1730 (4.4); 7.1703 (4.5); 7.1599 (2.7); 7.1546 (2.2); 7.1451 (1.2); 7.1393 (1.2); 7.1345 (0.7); 7.1204 (0.6); 7.0765 (1.1); 7.0602 (1.5); 7.0410 (0.7); 4.7418 (1.4); 4.7013 (1.7); 4.2623 (2.5); 4.2542 (2.6); 4.2485 (2.7); 4.2401 (3.8); 4.2002 (1.6); 3.8266 (0.6); 3.8162 (0.8); 3.8060 (1.0); 3.7960 (0.9); 3.7857 (0.6); 3.3424 (236.4); 3.2908 (1.6); 3.1672 (2.3); 3.1529 (2.5); 2.6746 (1.3); 2.6700 (1.8); 2.6654 (1.3); 2.6229 (1.4); 2.6038 (5.3); 2.5907 (1.6); 2.5851 (5.0); 2.5665 (2.8); 2.5549 (0.9); 2.5495 (0.7); 2.5448 (1.0); 2.5402 (2.2); 2.5233 (5.0); 2.5187 (7.7); 2.5100 (103.3); 2.5055 (221.3); 2.5008 (305.4); 2.4962 (213.2); 2.4916 (94.7); 2.4596 (0.6); 2.4548 (1.0); 2.4501 (1.6); 2.4456 (1.4); 2.4018 (0.6); 2.3829 (0.7); 2.3599 (1.2); 2.3369 (1.7); 2.3324 (1.8); 2.3277 (2.1); 2.3229 (1.6); 2.3183 (1.5); 2.2834 (1.9); 2.2749 (1.6); 2.2617 (2.0); 2.2488 (2.0); 2.2265 (1.5); 2.2090 (0.7); 2.1616 (0.5); 2.1422 (0.8); 2.1300 (0.6); 2.1180 (0.7); 2.1106 (1.0); 2.0866 (0.8); 2.0730 (1.0); 1.7871 (0.6); 1.7766 (0.8); 1.7663 (0.7); 1.7550 (0.7); 1.7449 (0.8); 1.2098 (1.5); 1.1936 (1.5); 1.1566 (7.0); 1.1378 (16.0); 1.1189 (6.8); 0.0080 (1.2); -0.0002 (41.8); -0.0085 (1.2) I.1-182: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.0946 (0.7); 7.4655 (3.6); 7.3567 (0.5); 7.3529 (0.6); 7.3307 (0.6); 7.1828 (0.6); 7.1790 (0.7); 7.1698 (0.6); 7.1665 (0.7); 7.0682 (0.6); 7.0520 (0.8); 4.7284 (0.9); 4.6890 (1.1); 4.2126 (1.2); 4.1730 (1.0); 4.0086 (1.9); 4.0026 (1.9); 3.9997 (2.2); 3.9958 (1.9); 3.9903 (2.0); 3.9815 (3.9); 3.9633 (4.0); 3.9452 (1.3); 3.7911 (0.6); 3.7811 (0.7); 3.7711 (0.6); 3.4698 (8.3); 2.5229 (1.4); 2.5185 (1.2); 2.5098 (16.8); 2.5052 (35.8); 2.5006 (50.3); 2.4960 (34.8); 2.4913 (15.5); 2.4763 (1.0); 2.3411 (0.7); 2.3224 (0.8); 2.2987 (0.5); 2.2722 (0.5); 2.2592 (0.6); 2.2482 (0.8); 2.2352 (0.8); 2.2118 (1.1); 2.2064 (0.5); 2.1902 (1.1); 2.1771 (0.9); 2.1694 (1.1); 2.1554 (0.8); 2.1195 (0.5); 2.0880 (0.6); 2.0638 (16.0); 1.7505 (0.5); 1.3113 (5.1); 1.2932 (11.7); 1.2750 (5.0); 1.2495 (0.7); -0.0002 (3.5) I.1-183: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.5312 (1.1); 8.5178 (0.6); 8.2879 (3.0); 8.2828 (3.0); 7.7049 (2.0); 7.6986 (1.9); 7.6844 (2.4); 7.6781 (2.3); 7.4784 (3.8); 7.4579 (3.2); 7.1343 (2.5); 7.1143 (6.6); 7.0907 (7.4); 7.0704 (2.6); 4.6568 (2.0); 4.6187 (2.2); 4.2673 (2.3); 4.2588 (2.6); 4.2526 (2.5); 4.2446 (2.3); 3.9968 (2.2); 3.9588 (2.0); 3.7359 (0.7); 3.7251 (0.9); 3.7145 (1.1); 3.7048 (0.9); 3.6940 (0.7); 3.3460 (56.6); 3.1687 (0.6); 2.5892 (1.4); 2.5783 (1.4); 2.5542 (1.8); 2.5431 (1.6); 2.5232 (1.2); 2.5184 (1.8); 2.5098 (29.4); 2.5052 (63.4); 2.5006 (88.2); 2.4960 (61.4); 2.4914 (27.5); 2.3611 (0.5); 2.3374 (1.3); 2.3274 (0.6); 2.3185 (1.2); 2.2959 (1.0); 2.2728 (16.0); 2.2545 (1.2); 2.2444 (1.4); 2.2305 (1.4); 2.2126 (0.6); 2.2031 (2.1); 2.1886 (0.7); 2.1810 (1.6); 2.1685 (1.4); 2.1460 (1.3); 2.0716 (0.7); 2.0529 (0.7); 2.0405 (0.6); 2.0288 (0.7); 2.0214 (0.9); 1.9971 (0.7); 1.7027 (0.6); 1.6915 (0.8); 1.6813 (0.7); 1.6697 (0.6); 1.6594 (0.7); -0.0002 (0.6) I.1-184: 1 H-NMR (400.6 MHz, d 6 -DMSO): δ= 7.5903 (6.8); 7.5867 (7.3); 7.5704 (8.7); 7.5667 (8.3); 7.3737 (8.6); 7.3541 (16.0); 7.3343 (9.2); 7.1940 (7.4); 7.1904 (7.7); 7.1746 (6.4); 7.1710 (6.2); 7.1587 (3.7); 7.0268 (7.6); 6.8950 (3.8); 4.6609 (6.9); 4.6192 (8.3); 4.2949 (8.1); 4.2532 (6.6); 3.8920 (1.6); 3.8824 (2.6); 3.8725 (3.4); 3.8630 (3.8); 3.8506 (3.4); 3.8410 (3.0); 3.4559 (5.6); 3.1673 (3.0); 2.7995 (4.0); 2.7899 (4.0); 2.7603 (5.0); 2.7507 (4.8); 2.6749 (1.5); 2.6703 (2.0); 2.6656 (1.6); 2.5238 (8.8); 2.5106 (101.5); 2.5060 (207.0); 2.5015 (282.6); 2.4969 (195.7); 2.4923 (88.3); 2.4775 (6.0); 2.4615 (3.1); 2.4547 (4.7); 2.4389 (4.6); 2.4209 (3.6); 2.4159 (3.5); 2.4014 (1.5); 2.3879 (1.4); 2.3391 (2.8); 2.3330 (2.1); 2.3282 (4.0); 2.3152 (4.7); 2.3037 (4.8); 2.2748 (5.9); 2.2692 (4.3); 2.2621 (3.0); 2.2560 (2.2); 2.2440 (3.5); 2.2314 (1.2); 2.2247 (2.0); 2.2196 (1.9); 2.2002 (1.0); 2.0857 (2.0); 2.0736 (3.2); 1.8267 (0.9); 1.8019 (2.3); 1.7934 (2.4); 1.7837 (2.8); 1.7765 (1.9); 1.7712 (2.0); 1.7632 (1.8); 1.7521 (2.0); 1.7408 (1.2); 1.3240 (0.5); 0.0080 (1.2); -0.0002 (31.2); -0.0085 (0.8) I.1-185: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 7.1473 (2.1); 7.1271 (6.6); 7.1088 (7.4); 7.0883 (2.3); 4.8808 (0.7); 4.8652 (2.0); 4.8495 (2.7); 4.8339 (2.0); 4.8182 (0.8); 4.6551 (1.9); 4.6168 (2.2); 4.0517 (2.2); 4.0134 (2.0); 3.7185 (0.7); 3.7081 (1.1); 3.6976 (1.2); 3.6875 (1.1); 3.6770 (0.8); 3.4114 (1.0); 3.3756 (116.5); 2.7000 (1.6); 2.6899 (1.7); 2.6713 (0.5); 2.6609 (2.2); 2.6507 (2.0); 2.5248 (0.8); 2.5200 (1.4); 2.5114 (28.3); 2.5069 (61.2); 2.5023 (83.4); 2.4977 (58.8); 2.4931 (26.8); 2.3906 (3.2); 2.3689 (2.6); 2.3514 (2.1); 2.3296 (2.1); 2.3246 (0.5); 2.2909 (0.9); 2.2756 (16.0); 2.2665 (1.8); 2.2523 (1.4); 2.2245 (0.7); 2.2109 (0.8); 2.1694 (0.5); 2.1501 (0.7); 2.1378 (0.6); 2.1320 (0.5); 2.1254 (0.6); 2.1197 (0.8); 2.1134 (0.6); 2.1001 (0.6); 2.0938 (0.6); 2.0753 (0.5); 1.7055 (0.6); 1.6943 (0.9); 1.6869 (0.5); 1.6834 (0.6); 1.6739 (0.7); 1.6697 (0.5); 1.6623 (0.8); 1.1504 (12.6); 1.1453 (12.8); 1.1347 (12.6); 1.1297 (12.7); -0.0002 (9.1) I.1-186: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.1468 (2.2); 7.1268 (6.2); 7.1053 (5.9); 7.0849 (2.0); 5.7713 (0.8); 5.7455 (1.2); 5.7284 (1.2); 5.7026 (0.9); 5.1026 (0.5); 5.0986 (1.3); 5.0938 (1.6); 5.0899 (0.6); 5.0555 (1.2); 5.0508 (2.0); 5.0482 (1.7); 5.0434 (1.2); 5.0257 (0.6); 5.0226 (1.3); 5.0178 (1.1); 4.6542 (1.6); 4.6159 (1.8); 4.0472 (2.3); 4.0431 (2.8); 4.0262 (5.1); 4.0096 (4.4); 3.7129 (0.6); 3.7023 (0.9); 3.6916 (1.0); 3.6815 (0.9); 3.6713 (0.6); 3.3891 (1.6); 3.3796 (1.2); 3.3722 (2.2); 3.3389 (363.2); 3.3104 (1.4); 3.3017 (1.1); 3.1667 (0.8); 2.7378 (1.2); 2.7278 (1.2); 2.6983 (1.5); 2.6882 (1.4); 2.6760 (1.2); 2.6712 (1.4); 2.6667 (1.2); 2.5568 (0.8); 2.5521 (0.8); 2.5471 (0.7); 2.5415 (1.2); 2.5363 (1.0); 2.5318 (1.2); 2.5245 (3.7); 2.5199 (5.4); 2.5112 (74.0); 2.5067 (155.1); 2.5021 (211.4); 2.4975 (150.0); 2.4930 (67.8); 2.4282 (1.8); 2.4166 (0.9); 2.4063 (1.7); 2.3889 (1.9); 2.3743 (1.0); 2.3669 (1.9); 2.3501 (0.8); 2.3380 (0.5); 2.3335 (1.0); 2.3289 (1.4); 2.3244 (1.0); 2.3197 (0.5); 2.3043 (1.0); 2.2911 (1.8); 2.2876 (3.2); 2.2845 (2.7); 2.2757 (16.0); 2.2612 (1.6); 2.2546 (1.1); 2.2473 (1.4); 2.2304 (0.7); 2.2192 (0.9); 2.2058 (1.0); 2.1411 (0.6); 2.1283 (0.6); 2.1223 (0.6); 2.1160 (0.7); 2.1099 (0.8); 2.1039 (0.5); 2.0904 (0.6); 2.0755 (0.5); 1.7149 (0.5); 1.7022 (0.7); 1.6907 (0.9); 1.6796 (0.7); 1.6702 (0.7); 1.6588 (0.8); 0.0080 (0.8); -0.0002 (28.0); -0.0085 (0.8) I.1-188: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.8853 (0.8); 7.3594 (0.6); 7.3554 (0.7); 7.3334 (0.7); 7.3295 (0.6); 7.1881 (0.7); 7.1844 (0.8); 7.1754 (0.7); 7.1718 (0.8); 7.0705 (0.7); 7.0543 (1.0); 7.0511 (0.9); 7.0350 (0.5); 4.7320 (1.1); 4.6922 (1.3); 4.2348 (1.4); 4.1951 (1.2); 3.7968 (0.6); 3.7865 (0.9); 3.7764 (0.6); 3.0530 (0.5); 3.0460 (0.5); 3.0348 (1.3); 3.0277 (1.1); 3.0208 (1.2); 3.0140 (1.3); 3.0022 (0.6); 2.9960 (0.6); 2.5117 (5.5); 2.5072 (12.1); 2.5025 (17.0); 2.4979 (12.6); 2.4933 (5.4); 2.4853 (1.1); 2.4623 (1.2); 2.4504 (1.2); 2.3572 (0.8); 2.3381 (0.8); 2.3344 (0.8); 2.3152 (0.6); 2.2891 (0.6); 2.2755 (0.8); 2.2651 (1.0); 2.2516 (0.9); 2.1893 (1.2); 2.1682 (1.2); 2.1545 (1.1); 2.1334 (1.1); 2.1259 (0.6); 2.1019 (0.5); 2.0944 (0.7); 2.0703 (0.5); 1.7397 (0.6); 1.7293 (0.5); 1.7078 (0.6); 1.5512 (0.8); 1.5344 (1.1); 1.5176 (1.0); 1.5009 (0.5); 1.2729 (1.4); 1.2550 (3.4); 1.2372 (3.3); 1.2193 (1.1); 0.8541 (16.0); 0.8375 (15.3); -0.0002 (1.9) I.1-189: 1 H-NMR (400.0 MHz, CDCl 3 ): δ= 7.5560 (5.9); 7.5530 (6.1); 7.5360 (6.4); 7.5330 (6.6); 7.5212 (0.8); 7.2782 (2.7); 7.2751 (2.8); 7.2623 (132.8); 7.2565 (6.9); 7.2413 (5.8); 7.2381 (5.7); 7.2110 (6.1); 7.2064 (7.5); 7.1920 (3.7); 7.1873 (3.4); 7.1267 (4.2); 7.1219 (4.0); 7.1087 (5.2); 7.1068 (5.2); 7.1038 (4.8); 7.1021 (4.9); 7.0948 (3.4); 7.0887 (3.5); 7.0838 (4.3); 7.0789 (2.3); 7.0762 (2.5); 7.0693 (4.4); 7.0624 (1.3); 7.0578 (1.8); 7.0500 (8.0); 7.0431 (7.7); 7.0397 (5.8); 7.0348 (10.0); 7.0264 (4.3); 7.0241 (3.8); 7.0140 (0.8); 7.0073 (0.7); 6.9982 (0.7); 5.5102 (2.0); 5.2991 (0.7); 4.8492 (3.9); 4.8456 (3.9); 4.8104 (4.5); 4.8068 (4.4); 4.2368 (5.8); 4.1981 (5.1); 3.9487 (0.9); 3.9377 (2.0); 3.9267 (2.4); 3.9177 (2.5); 3.9154 (2.6); 3.9065 (2.4); 3.8955 (2.1); 3.8846 (1.0); 3.5526 (2.5); 3.5480 (2.4); 3.5348 (6.3); 3.5309 (5.6); 3.5199 (5.5); 3.5160 (6.9); 3.5024 (2.7); 3.4989 (2.8); 2.9729 (8.0); 2.9556 (16.0); 2.9382 (7.2); 2.6001 (4.1); 2.5894 (4.1); 2.5640 (4.7); 2.5532 (4.6); 2.5196 (0.9); 2.5010 (1.2); 2.4977 (1.1); 2.4771 (3.0); 2.4580 (2.7); 2.4547 (2.5); 2.4347 (2.5); 2.4174 (3.0); 2.4029 (3.6); 2.3933 (4.2); 2.3789 (4.2); 2.3746 (1.5); 2.3601 (1.3); 2.3503 (2.0); 2.3361 (1.9); 2.2634 (1.6); 2.2443 (2.5); 2.2394 (1.5); 2.2307 (2.0); 2.2252 (1.6); 2.2201 (2.1); 2.2116 (2.8); 2.2065 (1.8); 2.2012 (1.2); 2.1925 (1.7); 2.1873 (2.2); 2.1683 (1.2); 2.1321 (5.4); 2.1094 (5.3); 2.0959 (4.8); 2.0733 (4.7); 1.8186 (1.4); 1.8074 (1.5); 1.8046 (1.7); 1.7940 (2.1); 1.7840 (1.9); 1.7808 (1.6); 1.7746 (1.5); 1.7714 (1.9); 1.7605 (1.7); 1.7510 (1.3); 1.7480 (1.2); 1.7366 (1.1); 0.0080 (1.1); -0.0002 (37.7); -0.0085 (1.1) I.1-190: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.9148 (1.0); 7.3566 (1.0); 7.3527 (1.0); 7.3467 (0.5); 7.3368 (0.6); 7.3309 (1.0); 7.3267 (0.9); 7.3105 (0.5); 7.2075 (0.6); 7.2034 (0.6); 7.1947 (0.6); 7.1875 (1.1); 7.1837 (1.1); 7.1747 (1.0); 7.1712 (1.1); 7.1673 (0.7); 7.1632 (0.6); 7.1543 (0.6); 7.1508 (0.6); 7.0711 (1.1); 7.0549 (1.5); 7.0358 (0.7); 4.7323 (1.7); 4.6926 (2.0); 4.2338 (2.2); 4.1940 (1.8); 3.8082 (0.7); 3.7979 (1.0); 3.7878 (1.3); 3.7775 (1.0); 3.7674 (0.7); 3.3174 (82.7); 3.0622 (0.8); 3.0441 (2.6); 3.0303 (2.8); 3.0261 (2.9); 3.0123 (2.7); 3.0082 (1.1); 2.9943 (0.9); 2.5233 (1.0); 2.5186 (1.5); 2.5100 (21.1); 2.5054 (45.2); 2.5008 (62.5); 2.4962 (43.6); 2.4916 (19.9); 2.4772 (1.5); 2.4541 (1.7); 2.4421 (1.9); 2.3815 (0.6); 2.3587 (1.2); 2.3368 (1.2); 2.3167 (1.0); 2.2855 (1.0); 2.2719 (1.2); 2.2614 (1.4); 2.2480 (1.4); 2.2439 (0.6); 2.2195 (0.8); 2.2063 (0.8); 2.1793 (2.0); 2.1581 (1.9); 2.1488 (0.7); 2.1444 (1.7); 2.1295 (1.0); 2.1234 (1.8); 2.1173 (0.7); 2.1102 (0.6); 2.1056 (0.8); 2.0980 (1.1); 2.0934 (0.6); 2.0785 (0.6); 2.0739 (0.8); 1.7541 (0.7); 1.7434 (1.0); 1.7333 (0.8); 1.7221 (0.8); 1.7116 (0.8); 1.7010 (0.5); 0.9946 (7.5); 0.9765 (16.0); 0.9584 (7.2); -0.0002 (1.1) I.1-191: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.2662 (0.8); 8.2461 (1.8); 8.2265 (1.0); 7.1440 (1.6); 7.1235 (8.3); 7.1152 (6.2); 7.0936 (1.2); 4.6607 (2.0); 4.6225 (2.2); 4.1993 (0.7); 4.1839 (0.7); 4.0557 (1.0); 4.0208 (1.5); 3.9834 (1.2); 3.6889 (1.0); 3.6794 (0.9); 3.3724 (1.0); 3.3540 (2.0); 3.3215 (663.9); 3.2731 (2.3); 3.1674 (0.9); 2.6746 (1.5); 2.6700 (2.2); 2.6653 (1.6); 2.5608 (1.2); 2.5234 (5.3); 2.5185 (7.8); 2.5100 (134.1); 2.5055 (291.3); 2.5009 (405.4); 2.4963 (285.9); 2.4918 (130.2); 2.4520 (1.4); 2.3736 (0.7); 2.3276 (3.0); 2.3232 (2.2); 2.2760 (16.0); 2.2554 (1.0); 2.2453 (1.1); 2.2310 (1.0); 2.2145 (1.1); 2.1920 (1.0); 2.1757 (0.9); 2.1517 (0.9); 2.1172 (0.8); 1.9985 (0.8); 1.5816 (0.7); 1.5101 (1.3); 1.4974 (1.8); 1.4862 (2.1); 1.4760 (1.3); 1.4628 (1.2); 0.8930 (6.6); 0.8769 (6.3); 0.8283 (5.7); 0.8250 (5.3); 0.8119 (5.8); -0.0002 (14.5) I.1-193: 1 H-NMR (400.0 MHz, CDCl3): δ= 7.2624 (10.9); 7.0456 (0.6); 7.0382 (0.8); 7.0354 (0.5); 7.0294 (0.8); 6.3377 (0.8); 6.3324 (0.9); 6.3197 (2.4); 6.3142 (1.3); 5.2992 (0.7); 4.2308 (0.5); 3.7742 (16.0); 2.7484 (0.6); 2.7313 (1.3); 2.7141 (0.6); - 0.0002 (3.1) I.1-194: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.4139 (3.9); 7.3961 (10.3); 7.3770 (8.5); 7.3537 (3.3); 7.3337 (6.0); 7.3118 (4.7); 7.2911 (2.0); 7.2186 (11.3); 7.2152 (15.4); 7.1973 (11.5); 7.1268 (2.8); 7.1124 (2.7); 6.9103 (2.5); 4.5334 (2.0); 4.4962 (2.4); 4.1167 (2.4); 4.0751 (2.0); 3.8125 (2.4); 3.3769 (0.8); 3.3285 (209.0); 3.2797 (1.4); 3.2234 (0.6); 3.1689 (2.0); 3.1051 (16.0); 2.6747 (1.1); 2.6701 (1.5); 2.6654 (1.0); 2.6609 (0.6); 2.5401 (0.6); 2.5234 (3.4); 2.5187 (5.2); 2.5101 (89.3); 2.5055 (193.0); 2.5009 (268.9); 2.4963 (187.8); 2.4917 (84.6); 2.4517 (1.4); 2.4294 (1.8); 2.3901 (2.2); 2.3323 (1.4); 2.3277 (1.9); 2.3231 (1.4); 2.2402 (4.0); 2.2191 (4.6); 2.2051 (4.1); 2.1778 (3.2); 2.1425 (2.4); 2.1222 (1.9); 2.1008 (1.9); 2.0718 (2.4); 1.6628 (2.0); -0.0002 (1.3) I.1-195: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.8098 (0.8); 7.7906 (0.8); 7.1441 (1.9); 7.1238 (7.4); 7.1094 (8.2); 7.0888 (2.0); 4.6573 (2.0); 4.6194 (2.2); 4.0180 (2.3); 3.9800 (2.0); 3.8206 (0.8); 3.8040 (1.2); 3.7853 (1.2); 3.7689 (0.8); 3.7185 (0.7); 3.7080 (0.9); 3.6973 (1.1); 3.6877 (1.0); 3.6766 (0.7); 3.3845 (24.5); 3.1681 (1.1); 2.6694 (0.7); 2.5229 (1.6); 2.5181 (2.4); 2.5094 (39.5); 2.5049 (85.3); 2.5003 (119.0); 2.4957 (83.1); 2.4911 (37.4); 2.4575 (1.7); 2.4461 (1.8); 2.4232 (1.9); 2.4119 (1.8); 2.3640 (0.5); 2.3411 (1.2); 2.3316 (0.6); 2.3224 (1.5); 2.2995 (1.0); 2.2757 (16.0); 2.2657 (1.4); 2.2517 (1.2); 2.2414 (1.3); 2.2276 (1.3); 2.2100 (0.6); 2.1995 (0.7); 2.1859 (0.6); 2.0826 (1.7); 2.0717 (0.7); 2.0603 (1.8); 2.0483 (1.6); 2.0310 (0.8); 2.0258 (1.8); 2.0198 (0.8); 2.0122 (0.9); 2.0075 (0.6); 1.9929 (0.6); 1.9879 (0.7); 1.7033 (0.6); 1.6917 (0.8); 1.6813 (0.7); 1.6702 (0.7); 1.6598 (0.7); 1.0273 (12.2); 1.0228 (12.3); 1.0109 (12.2); 1.0064 (12.1); 0.0080 (1.0); -0.0002 (33.6); -0.0085 (1.0) I.1-196: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 7.0772 (0.5); 4.7265 (0.6); 4.6868 (0.7); 4.2454 (0.7); 4.2058 (0.6); 3.3204 (27.1); 3.2966 (1.1); 2.6575 (14.5); 2.5190 (0.6); 2.5104 (9.0); 2.5058 (19.2); 2.5012 (26.3); 2.4965 (18.2); 2.4919 (8.1); 2.3812 (0.7); 2.3693 (0.8); 2.3500 (0.5); 2.3462 (0.8); 2.3341 (1.0); 2.3279 (0.5); 2.2205 (0.5); 1.9824 (0.8); 1.9602 (0.8); 1.9475 (0.7); 1.9252 (0.7); 1.7644 (0.5); 1.7551 (15.5); 1.7540 (16.0); 1.5963 (4.6); -0.0002 (1.0) I.1-197: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.5561 (2.6); 8.5420 (4.8); 8.5278 (2.5); 8.2898 (11.9); 8.2884 (12.6); 8.2836 (12.5); 8.2821 (12.1); 7.7063 (8.7); 7.7000 (8.5); 7.6858 (10.7); 7.6795 (10.3); 7.4756 (15.5); 7.4552 (12.9); 7.3763 (1.7); 7.3727 (1.8); 7.3523 (4.0); 7.3361 (2.5); 7.3303 (4.0); 7.3098 (2.2); 7.3058 (2.0); 7.2025 (2.3); 7.1985 (2.4); 7.1896 (2.4); 7.1859 (2.9); 7.1824 (4.2); 7.1788 (4.6); 7.1698 (4.1); 7.1662 (4.6); 7.1622 (2.9); 7.1582 (2.8); 7.1493 (2.3); 7.1457 (2.5); 7.0695 (4.3); 7.0535 (5.9); 7.0501 (5.6); 7.0340 (3.1); 4.7262 (6.7); 4.6866 (7.8); 4.3084 (1.5); 4.2934 (1.5); 4.2700 (8.9); 4.2560 (16.0); 4.2423 (9.1); 4.2239 (8.6); 4.2042 (1.7); 4.1842 (7.3); 3.8354 (1.3); 3.8244 (2.8); 3.8139 (4.0); 3.8037 (4.7); 3.7936 (4.0); 3.7831 (2.9); 3.7724 (1.5); 3.3271 (164.8); 3.2779 (1.3); 3.1689 (0.7); 2.6747 (1.3); 2.6699 (1.8); 2.6654 (1.3); 2.6073 (5.9); 2.5962 (6.0); 2.5719 (7.1); 2.5608 (7.0); 2.5403 (1.1); 2.5235 (4.1); 2.5188 (6.0); 2.5102 (102.8); 2.5056 (226.1); 2.5009 (318.5); 2.4963 (221.4); 2.4917 (98.4); 2.4557 (1.5); 2.4513 (1.9); 2.4469 (1.5); 2.3916 (1.5); 2.3725 (2.0); 2.3684 (2.0); 2.3494 (4.9); 2.3276 (5.9); 2.3072 (4.0); 2.2818 (9.3); 2.2697 (5.1); 2.2594 (12.5); 2.2459 (11.4); 2.2243 (6.1); 2.2172 (3.2); 2.2041 (3.0); 2.1497 (2.0); 2.1303 (3.5); 2.1259 (2.0); 2.1181 (2.6); 2.1110 (2.1); 2.1064 (3.0); 2.0989 (4.1); 2.0942 (2.5); 2.0872 (1.6); 2.0794 (2.4); 2.0748 (3.1); 2.0628 (0.7); 2.0556 (1.3); 1.7673 (1.7); 1.7546 (2.5); 1.7435 (3.5); 1.7332 (2.9); 1.7224 (2.8); 1.7118 (3.1); 1.7011 (1.9); 1.6876 (1.3); 0.0080 (1.1); -0.0002 (35.2); -0.0085 (0.9) I.1-198: 1 H-NMR (400.1 MHz, CDCl3): δ= 7.2684 (2.9); 7.2646 (15.8); 7.2627 (16.8); 7.2550 (1.2); 7.1357 (0.6); 7.1152 (1.4); 7.1057 (0.9); 7.1001 (0.9); 7.0941 (1.2); 7.0895 (1.7); 7.0803 (1.2); 7.0710 (1.2); 7.0595 (0.7); 7.0547 (0.7); 6.9907 (0.9); 6.9853 (1.0); 6.9804 (0.9); 6.9701 (0.7); 6.9646 (0.7); 6.0680 (0.8); 4.6967 (1.7); 4.6585 (2.0); 4.1544 (2.0); 4.1161 (1.8); 4.0200 (0.6); 4.0120 (0.8); 4.0004 (1.2); 3.9884 (0.8); 3.9807 (0.7); 3.9689 (0.3); 3.7045 (16.0); 3.5159 (0.6); 3.5021 (1.7); 3.4875 (2.7); 3.4794 (1.1); 3.4731 (1.7); 3.4595 (0.7); 2.5553 (0.4); 2.5299 (2.7); 2.5127 (3.8); 2.5004 (2.6); 2.4912 (2.4); 2.4779 (1.4); 2.4700 (1.1); 2.4542 (1.6); 2.4487 (1.2); 2.4414 (1.6); 2.4347 (1.0); 2.4248 (1.0); 2.4106 (1.1); 2.3917 (0.3); 2.3818 (0.5); 2.3679 (0.5); 2.2943 (0.4); 2.2751 (0.7); 2.2616 (0.6); 2.2552 (0.5); 2.2511 (0.6); 2.2427 (0.9); 2.2323 (0.4); 2.2227 (0.5); 2.2188 (0.6); 2.1624 (1.4); 2.1426 (1.4); 2.1259 (1.2); 2.1060 (1.1); 1.9301 (1.0); 1.8053 (0.4); 1.7932 (0.6); 1.7813 (0.8); 1.7719 (0.8); 1.7602 (0.7); 1.7581 (0.7); 1.7487 (0.6); 1.7372 (0.5); 0.0057 (0.7); 0.0019 (4.1) I.1-199: 1 H-NMR (400.0 MHz, CDCl 3 ): δ= 7.5218 (1.1); 7.2628 (208.2); 7.1612 (2.9); 7.1452 (3.6); 7.1407 (6.8); 7.1249 (8.2); 7.1195 (4.4); 7.1147 (2.7); 7.1111 (2.1); 7.1077 (1.9); 7.1010 (6.4); 7.0917 (2.5); 7.0886 (3.3); 7.0846 (3.8); 7.0821 (4.2); 7.0752 (6.9); 7.0686 (2.1); 7.0636 (3.0); 7.0558 (13.8); 7.0491 (12.1); 7.0455 (9.5); 7.0410 (17.0); 7.0324 (7.1); 7.0303 (6.2); 7.0206 (1.2); 7.0134 (1.0); 6.9988 (1.2); 6.8491 (3.0); 6.8467 (2.8); 6.8426 (3.6); 6.8403 (3.9); 6.8283 (4.8); 6.8266 (4.6); 6.8199 (8.8); 6.8162 (5.9); 6.8080 (3.3); 6.7994 (4.8); 6.7938 (6.2); 6.7916 (6.3); 6.7884 (3.5); 6.7851 (4.2); 6.7693 (5.1); 6.7629 (3.8); 5.5040 (3.2); 5.2997 (3.6); 4.8528 (6.6); 4.8491 (6.6); 4.8141 (7.5); 4.8104 (7.4); 4.2353 (9.8); 4.1966 (8.8); 3.9365 (1.6); 3.9254 (3.3); 3.9145 (4.1); 3.9036 (4.3); 3.8943 (4.1); 3.8834 (3.4); 3.8725 (1.6); 3.5086 (0.8); 3.4922 (3.7); 3.4841 (3.4); 3.4747 (8.1); 3.4674 (8.1); 3.4594 (7.8); 3.4518 (8.5); 3.4421 (3.6); 3.4350 (3.9); 3.4174 (0.9); 2.8232 (8.3); 2.8060 (16.0); 2.7888 (7.5); 2.5970 (6.9); 2.5862 (6.9); 2.5608 (8.1); 2.5500 (7.9); 2.5223 (1.4); 2.5037 (1.9); 2.5002 (1.8); 2.4800 (5.0); 2.4607 (4.5); 2.4573 (4.3); 2.4374 (4.2); 2.4229 (5.0); 2.4084 (5.8); 2.3988 (6.9); 2.3844 (6.9); 2.3801 (2.5); 2.3655 (2.0); 2.3558 (3.1); 2.3415 (3.1); 2.2723 (2.7); 2.2531 (4.2); 2.2484 (2.4); 2.2396 (3.2); 2.2341 (2.7); 2.2290 (3.5); 2.2206 (4.7); 2.2155 (2.9); 2.2102 (2.0); 2.2014 (2.8); 2.1962 (3.7); 2.1773 (2.1); 2.1379 (9.3); 2.1154 (9.0); 2.1017 (8.0); 2.0792 (7.9); 1.8279 (2.3); 1.8166 (2.5); 1.8139 (2.9); 1.8031 (3.4); 1.7933 (3.2); 1.7900 (2.7); 1.7839 (2.5); 1.7807 (3.1); 1.7697 (2.8); 1.7603 (2.2); 1.7572 (2.0); 1.7458 (1.8); 0.0079 (1.8); -0.0002 (56.9); -0.0085 (1.6) I.1-200: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.1451 (2.0); 7.1250 (6.6); 7.1072 (7.4); 7.1019 (1.5); 7.0867 (2.2); 5.0355 (0.8); 5.0258 (1.0); 5.0192 (1.4); 5.0125 (0.7); 5.0043 (0.8); 4.6507 (1.9); 4.6125 (2.1); 4.0474 (2.2); 4.0092 (1.9); 3.7079 (0.7); 3.6975 (1.1); 3.6872 (1.2); 3.6770 (1.1); 3.6667 (0.7); 3.4267 (17.1); 2.6885 (1.6); 2.6784 (1.7); 2.6493 (2.1); 2.6392 (2.0); 2.5250 (0.6); 2.5202 (0.9); 2.5115 (13.2); 2.5070 (27.9); 2.5024 (37.6); 2.4978 (26.1); 2.4932 (11.7); 2.4055 (0.6); 2.4009 (2.6); 2.3797 (2.6); 2.3618 (2.2); 2.3403 (2.5); 2.2886 (1.0); 2.2749 (16.0); 2.2641 (1.6); 2.2499 (1.3); 2.2221 (0.8); 2.2084 (0.8); 2.1425 (0.6); 2.1304 (0.6); 2.1245 (0.5); 2.1177 (0.6); 2.1125 (0.8); 2.1058 (0.6); 2.0926 (0.6); 2.0861 (0.6); 1.8005 (0.6); 1.7951 (0.6); 1.7864 (1.2); 1.7684 (1.2); 1.7622 (0.8); 1.7564 (0.9); 1.7495 (0.6); 1.7177 (0.5); 1.7044 (0.6); 1.6932 (0.9); 1.6859 (0.6); 1.6823 (0.7); 1.6725 (0.7); 1.6685 (0.5); 1.6611 (0.8); 1.6502 (0.6); 1.6153 (0.6); 1.6025 (1.0); 1.5966 (1.2); 1.5887 (1.0); 1.5839 (1.1); 1.5733 (1.4); 1.5608 (1.5); 1.5521 (2.0); 1.5463 (2.3); 1.5415 (2.6); 1.5359 (1.9); 1.5315 (1.9); 1.5266 (2.1); 1.5182 (2.3); 1.5145 (2.3); 1.5066 (1.6); 1.4979 (1.1); -0.0002 (3.5) I.1-202: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 7.8495 (5.3); 7.3770 (3.1); 7.3732 (3.1); 7.3525 (7.5); 7.3309 (7.4); 7.3104 (4.0); 7.3064 (3.8); 7.2066 (4.2); 7.2027 (4.3); 7.1938 (4.3); 7.1866 (7.9); 7.1829 (8.2); 7.1738 (7.6); 7.1702 (8.5); 7.1664 (5.2); 7.1623 (4.8); 7.1535 (4.4); 7.1498 (4.7); 7.0695 (7.8); 7.0534 (10.9); 7.0342 (5.8); 4.7323 (12.7); 4.6930 (14.7); 4.2237 (16.0); 4.1841 (13.9); 3.8104 (2.6); 3.7998 (5.3); 3.7890 (7.3); 3.7790 (9.9); 3.7690 (7.4); 3.7586 (5.8); 3.7477 (2.6); 3.3210 (402.5); 3.1678 (1.1); 2.6741 (2.5); 2.6695 (3.6); 2.6650 (2.4); 2.5411 (80.2); 2.5296 (86.2); 2.5231 (10.4); 2.5183 (12.4); 2.5096 (208.9); 2.5051 (453.5); 2.5005 (641.2); 2.4959 (442.0); 2.4913 (200.8); 2.4649 (13.8); 2.4531 (13.1); 2.3966 (3.4); 2.3776 (4.3); 2.3549 (9.9); 2.3359 (9.2); 2.3320 (10.4); 2.3226 (3.3); 2.3128 (7.4); 2.2815 (7.5); 2.2680 (9.1); 2.2574 (11.2); 2.2441 (10.8); 2.2263 (3.7); 2.2154 (5.8); 2.2024 (5.9); 2.1860 (13.8); 2.1647 (13.5); 2.1509 (11.6); 2.1454 (5.0); 2.1294 (12.4); 2.1138 (5.2); 2.1067 (4.3); 2.1022 (5.9); 2.0945 (8.4); 2.0899 (4.9); 2.0828 (3.0); 2.0750 (4.7); 2.0705 (6.4); 2.0509 (2.8); 1.7555 (3.4); 1.7428 (5.0); 1.7320 (6.9); 1.7215 (5.5); 1.7108 (5.5); 1.7002 (6.1); 1.6896 (3.8); 1.6764 (2.6); 0.0080 (3.7); -0.0002 (124.4); -0.0086 (3.4) I.1-203: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.1470 (1.8); 7.1266 (7.0); 7.1130 (7.8); 7.1073 (1.4); 7.0923 (1.9); 5.9126 (0.6); 5.8987 (1.2); 5.8860 (0.8); 5.8726 (1.4); 5.8695 (0.7); 5.8587 (0.7); 5.8557 (1.5); 5.8429 (0.9); 5.8295 (1.5); 5.8157 (0.7); 5.2970 (0.8); 5.2930 (2.3); 5.2888 (2.4); 5.2847 (0.8); 5.2539 (0.7); 5.2498 (2.0); 5.2457 (2.1); 5.2416 (0.7); 5.2203 (0.9); 5.2169 (2.2); 5.2131 (2.0); 5.2097 (0.8); 5.1941 (0.8); 5.1908 (2.0); 5.1869 (1.8); 5.1835 (0.7); 4.6592 (1.9); 4.6210 (2.2); 4.5164 (2.5); 4.5129 (4.3); 4.5093 (2.5); 4.5026 (2.4); 4.4991 (4.1); 4.4956 (2.3); 4.0594 (2.2); 4.0213 (2.0); 3.7317 (0.8); 3.7212 (1.1); 3.7107 (1.2); 3.7003 (1.1); 3.6899 (0.8); 3.5667 (6.1); 2.7983 (1.5); 2.7882 (1.5); 2.7584 (1.9); 2.7484 (1.8); 2.5204 (0.6); 2.5118 (7.8); 2.5073 (16.4); 2.5027 (22.1); 2.4981 (15.3); 2.4935 (6.9); 2.4862 (2.2); 2.4641 (2.0); 2.4463 (2.0); 2.4242 (1.9); 2.4040 (1.1); 2.3859 (0.8); 2.3804 (0.8); 2.3623 (0.8); 2.2892 (1.0); 2.2753 (16.0); 2.2648 (1.6); 2.2511 (1.2); 2.2229 (0.8); 2.2097 (0.8); 2.1511 (0.7); 2.1386 (0.6); 2.1326 (0.5); 2.1262 (0.6); 2.1201 (0.8); 2.1142 (0.6); 2.1006 (0.5); 2.0948 (0.6); 1.7136 (0.6); 1.7024 (0.9); 1.6944 (0.6); 1.6914 (0.7); 1.6820 (0.7); 1.6782 (0.5); 1.6705 (0.8); -0.0002 (3.3) I.1-204: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.6224 (0.5); 7.6098 (4.0); 7.6044 (4.2); 7.4073 (1.9); 7.4018 (1.8); 7.3864 (2.4); 7.3810 (2.4); 7.2661 (3.0); 7.2453 (2.3); 4.6184 (1.7); 4.5776 (2.0); 4.2290 (1.9); 4.1881 (1.6); 4.0262 (0.5); 3.9644 (0.8); 3.8024 (0.9); 3.7917 (1.5); 3.7799 (2.2); 3.7387 (16.0); 3.1685 (10.4); 2.6701 (0.5); 2.5404 (1.4); 2.5304 (1.5); 2.5236 (1.6); 2.5189 (2.3); 2.5102 (30.2); 2.5056 (64.5); 2.5010 (89.1); 2.4963 (62.4); 2.4918 (28.7); 2.3915 (0.9); 2.3730 (0.8); 2.3693 (0.7); 2.3509 (0.6); 2.3278 (0.6); 2.2839 (0.6); 2.2709 (0.7); 2.2597 (1.0); 2.2468 (1.1); 2.2233 (1.4); 2.2184 (0.8); 2.2068 (0.8); 2.2005 (1.5); 2.1858 (1.7); 2.1737 (0.5); 2.1671 (0.5); 2.1628 (1.4); 2.1551 (0.8); 1.7764 (0.6); 1.7651 (0.7); 1.7545 (0.6); 1.7467 (0.7); 1.7343 (0.6); -0.0002 (9.3) I.1-205: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 11.7795 (1.4); 7.5926 (1.1); 7.5890 (1.1); 7.5726 (1.3); 7.5689 (1.2); 7.3775 (1.3); 7.3579 (2.5); 7.3381 (1.4); 7.1927 (1.1); 7.1892 (1.1); 7.1733 (1.0); 7.1697 (0.9); 4.6722 (1.1); 4.6304 (1.3); 4.2906 (1.2); 4.2489 (1.0); 3.8733 (0.6); 3.8627 (0.5); 3.3634 (36.0); 3.1854 (16.0); 3.1683 (5.1); 2.7287 (0.7); 2.7183 (0.7); 2.6905 (1.0); 2.6799 (1.0); 2.6697 (0.5); 2.5232 (1.1); 2.5184 (1.7); 2.5099 (27.0); 2.5053 (57.5); 2.5006 (78.5); 2.4960 (54.6); 2.4914 (24.6); 2.4601 (1.0); 2.4382 (1.2); 2.4219 (0.9); 2.4152 (0.7); 2.4002 (0.8); 2.3326 (0.6); 2.3274 (0.6); 2.3220 (0.9); 2.3100 (0.7); 2.2818 (1.0); 2.2727 (0.7); 2.2457 (0.6); - 0.0002 (3.3) I.1-206: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 7.1480 (1.1); 7.1418 (1.1); 7.1276 (4.4); 7.1151 (4.6); 7.0944 (1.0); 7.0860 (1.6); 7.0660 (0.8); 4.7054 (1.0); 4.6673 (1.2); 4.1760 (2.2); 4.0472 (1.2); 4.0338 (6.3); 4.0087 (1.0); 3.9820 (0.5); 3.7219 (0.6); 3.7106 (0.6); 3.7008 (0.5); 3.6718 (7.4); 3.6171 (16.0); 3.3633 (0.9); 3.3152 (206.8); 3.2658 (1.7); 3.1682 (0.8); 2.9415 (15.3); 2.8031 (0.6); 2.7936 (0.7); 2.7656 (5.4); 2.7534 (0.8); 2.6743 (1.0); 2.6695 (1.6); 2.6649 (1.2); 2.6601 (0.6); 2.5500 (0.6); 2.5453 (0.5); 2.5398 (0.8); 2.5230 (3.1); 2.5183 (4.8); 2.5096 (86.8); 2.5050 (193.2); 2.5004 (272.7); 2.4958 (189.3); 2.4912 (84.6); 2.4671 (1.1); 2.4606 (1.6); 2.4552 (1.5); 2.4505 (1.8); 2.4455 (1.7); 2.4208 (0.9); 2.3967 (0.6); 2.3318 (1.4); 2.3273 (1.7); 2.3226 (1.2); 2.3177 (0.7); 2.2750 (10.6); 2.2587 (0.6); 2.2461 (0.6); 2.2346 (0.7); 2.2221 (0.7); 2.0716 (1.1); -0.0002 (16.0) I.1-207: 1 H-NMR (400.1 MHz, d6-DMSO): δ= 8.2967 (1.1); 8.2902 (1.2); 8.2747 (1.2); 8.2688 (1.2); 7.3913 (0.4); 7.3861 (0.3); 7.3703 (1.0); 7.3654 (0.9); 7.3499 (1.0); 7.3453 (1.1); 7.3297 (0.4); 7.3246 (0.6); 7.2223 (0.6); 7.2025 (1.2); 7.1900 (1.3); 7.1862 (1.1); 7.1821 (0.9); 7.1697 (0.8); 7.1151 (0.8); 7.1036 (1.1); 7.0988 (1.2); 7.0946 (1.2); 7.0785 (2.0); 7.0588 (2.4); 6.9965 (2.2); 6.9775 (1.5); 6.8658 (1.9); 6.8477 (2.0); 4.8415 (0.8); 4.8195 (1.7); 4.7935 (2.4); 4.7526 (2.1); 4.2962 (1.2); 4.2812 (1.3); 4.2566 (1.1); 4.2410 (1.1); 3.8952 (0.4); 3.8852 (0.7); 3.8750 (1.0); 3.8654 (1.1); 3.8546 (1.0); 3.8454 (0.8); 3.8351 (0.5); 3.3681 (1.0); 3.3188 (110.0); 3.1684 (1.5); 2.9753 (1.1); 2.9560 (1.2); 2.9370 (1.4); 2.9174 (1.3); 2.6740 (0.5); 2.6695 (0.7); 2.6620 (1.0); 2.6512 (0.8); 2.6402 (0.8); 2.6285 (1.6); 2.6172 (1.0); 2.6057 (1.0); 2.5945 (0.9); 2.5547 (0.6); 2.5502 (0.9); 2.5456 (0.8); 2.5397 (0.9); 2.5229 (1.6); 2.5182 (2.3); 2.5097 (37.1); 2.5051 (81.0); 2.5005 (113.2); 2.4960 (84.2); 2.4915 (43.1); 2.4527 (1.1); 2.4481 (0.7); 2.4388 (0.9); 2.4158 (1.5); 2.4095 (1.6); 2.3970 (1.4); 2.3908 (1.1); 2.3778 (1.6); 2.3548 (0.8); 2.3446 (1.2); 2.3360 (0.9); 2.3322 (0.9); 2.3270 (1.2); 2.3229 (2.4); 2.3166 (1.6); 2.3103 (2.0); 2.2985 (1.9); 2.2942 (1.6); 2.2885 (1.4); 2.2823 (1.6); 2.2691 (0.9); 2.2521 (16.0); 2.2295 (1.0); 2.2180 (0.7); 2.2065 (0.8); 2.1985 (0.7); 2.1891 (1.0); 2.1742 (1.2); 2.1657 (1.1); 2.1543 (1.4); 2.1331 (1.1); 2.1139 (0.5); 2.0718 (0.4); 1.9069 (0.4); 1.8954 (0.5); 1.8766 (0.6); 1.8659 (0.7); 1.8553 (0.7); 1.8445 (0.6); 1.8241 (0.4); 1.1273 (6.0); 1.1215 (6.2); 1.1106 (6.2); 1.1048 (6.0) I.1-210: 1 H-NMR (400.1 MHz, d 6 -DMSO): δ= 7.4204 (3.6); 7.3992 (7.5); 7.3934 (4.3); 7.3780 (4.5); 7.3722 (7.7); 7.3510 (3.9); 7.2972 (3.4); 7.2920 (3.6); 7.2775 (3.6); 7.2719 (4.3); 7.2684 (4.3); 7.2629 (3.9); 7.2485 (3.4); 7.2435 (3.6); 7.2038 (6.0); 7.0960 (3.9); 7.0902 (4.1); 7.0853 (4.2); 7.0721 (16.0); 6.9406 (6.4); 4.5633 (7.8); 4.5240 (9.6); 4.3451 (0.3); 4.1739 (9.8); 4.1513 (0.4); 4.1347 (8.2); 3.8432 (1.4); 3.8321 (2.9); 3.8214 (4.3); 3.8111 (5.1); 3.8011 (4.5); 3.7907 (3.3); 3.7800 (1.7); 2.8080 (5.0); 2.7975 (5.3); 2.7682 (6.5); 2.7578 (6.5); 2.6695 (0.5); 2.5100 (31.3); 2.5057 (73.6); 2.5011 (108.0); 2.4966 (82.5); 2.4922 (42.2); 2.4658 (7.5); 2.4437 (7.2); 2.4259 (6.3); 2.4167 (3.0); 2.4040 (6.2); 2.3988 (6.3); 2.3801 (4.6); 2.3753 (4.4); 2.3570 (4.0); 2.3326 (0.7); 2.3283 (0.8); 2.3105 (3.3); 2.2970 (3.8); 2.2863 (5.1); 2.2727 (5.3); 2.2558 (1.5); 2.2445 (3.0); 2.2318 (3.3); 2.2103 (2.2); 2.1922 (3.2); 2.1795 (2.6); 2.1734 (2.5); 2.1677 (2.6); 2.1608 (4.0); 2.1493 (1.8); 2.1414 (2.4); 2.1364 (2.8); 2.1174 (1.3); 2.0715 (1.2); 1.7357 (1.5); 1.7241 (2.8); 1.7127 (3.4); 1.7016 (3.3); 1.6924 (3.4); 1.6809 (3.2); 1.6694 (2.3); 1.6566 (1.6); 0.0084 (0.4); 0.0000 (21.2) I.1-211: 1 H-NMR (400.0 MHz, CDCl3): δ= 7.2626 (43.0); 7.0969 (1.1); 7.0845 (0.7); 7.0813 (0.7); 7.0783 (0.8); 7.0703 (1.2); 7.0583 (0.6); 7.0541 (1.3); 7.0505 (2.4); 7.0434 (2.9); 7.0403 (1.9); 7.0349 (3.1); 7.0245 (1.4); 6.7513 (3.3); 6.7316 (4.4); 6.6546 (3.1); 6.6508 (3.6); 6.6154 (2.2); 6.6111 (1.9); 6.5958 (1.7); 6.5914 (1.5); 5.9379 (2.2); 5.9339 (16.0); 5.9301 (2.2); 5.4159 (0.7); 5.2995 (3.0); 4.8498 (1.4); 4.8463 (1.3); 4.8111 (1.5); 4.8074 (1.5); 4.2272 (2.0); 4.1885 (1.7); 3.9359 (0.7); 3.9249 (0.8); 3.9146 (0.9); 3.9049 (0.8); 3.8940 (0.7); 3.4826 (0.8); 3.4654 (1.8); 3.4502 (2.8); 3.4350 (1.7); 3.4183 (0.8); 2.7252 (2.4); 2.7080 (4.8); 2.6908 (2.2); 2.5840 (1.4); 2.5730 (1.4); 2.5479 (1.6); 2.5369 (1.6); 2.4781 (1.0); 2.4589 (0.9); 2.4554 (0.8); 2.4358 (0.8); 2.4218 (1.0); 2.4072 (1.2); 2.3977 (1.4); 2.3833 (1.4); 2.3790 (0.5); 2.3547 (0.6); 2.3405 (0.6); 2.2785 (0.6); 2.2594 (0.8); 2.2546 (0.5); 2.2459 (0.6); 2.2404 (0.5); 2.2353 (0.7); 2.2269 (0.9); 2.2219 (0.6); 2.2077 (0.6); 2.2026 (0.7); 2.1274 (1.8); 2.1051 (1.8); 2.0913 (1.6); 2.0691 (1.5); 1.8164 (0.6); 1.8055 (0.7); 1.7958 (0.6); 1.7926 (0.5); 1.7865 (0.5); 1.7834 (0.6); 1.7723 (0.6); -0.0002 (12.1) I.1-212: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.1480 (2.0); 7.1277 (7.2); 7.1122 (7.9); 7.1068 (1.5); 7.0916 (2.1); 4.7365 (0.6); 4.7280 (0.6); 4.7208 (1.3); 4.7124 (1.2); 4.7051 (1.3); 4.6967 (1.2); 4.6894 (0.7); 4.6810 (0.6); 4.6688 (1.5); 4.6307 (1.7); 4.0492 (2.3); 4.0111 (2.0); 3.7159 (0.7); 3.7054 (1.0); 3.6952 (1.1); 3.6846 (1.0); 3.6741 (0.7); 3.4042 (86.0); 3.3688 (1.4); 2.7392 (0.9); 2.7321 (1.0); 2.7295 (1.1); 2.7224 (0.9); 2.7002 (1.2); 2.6931 (1.3); 2.6904 (1.3); 2.6835 (1.1); 2.6716 (0.5); 2.5250 (1.4); 2.5203 (1.9); 2.5116 (27.8); 2.5071 (59.4); 2.5025 (81.5); 2.4979 (57.9); 2.4933 (26.4); 2.4090 (1.5); 2.4030 (1.4); 2.3947 (0.9); 2.3870 (1.3); 2.3807 (1.5); 2.3701 (1.6); 2.3641 (1.2); 2.3482 (1.2); 2.3418 (1.0); 2.3292 (0.5); 2.2920 (0.7); 2.2750 (16.0); 2.2533 (1.1); 2.2277 (0.6); 2.2254 (0.5); 2.2137 (0.6); 2.1683 (0.5); 2.1490 (0.7); 2.1367 (0.6); 2.1310 (0.5); 2.1242 (0.6); 2.1175 (0.8); 2.1123 (0.6); 2.0990 (0.5); 2.0928 (0.6); 1.7130 (0.5); 1.7000 (0.8); 1.6887 (0.8); 1.6787 (0.6); 1.6681 (0.8); 1.6565 (0.6); 1.4960 (1.3); 1.4889 (1.8); 1.4796 (1.7); 1.4770 (1.7); 1.4730 (2.0); 1.4703 (2.0); 1.4612 (1.7); 1.4544 (1.9); 1.4427 (0.6); 1.4361 (0.6); 1.1209 (8.4); 1.1172 (7.9); 1.1052 (8.4); 1.1015 (7.8); 0.8241 (5.4); 0.8056 (11.0); 0.7869 (4.8); -0.0002 (9.1) I.1-213: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 7.7544 (1.1); 7.7339 (1.2); 7.3757 (0.5); 7.3553 (1.2); 7.3338 (1.2); 7.3127 (0.6); 7.2094 (0.6); 7.2062 (0.6); 7.1895 (1.2); 7.1857 (1.2); 7.1735 (1.3); 7.1655 (0.7); 7.1533 (0.7); 7.0772 (1.2); 7.0611 (1.7); 7.0419 (0.9); 4.7378 (1.9); 4.6981 (2.2); 4.2415 (2.3); 4.2015 (1.9); 3.8041 (0.8); 3.7940 (1.1); 3.7838 (1.4); 3.7734 (1.1); 3.7636 (0.8); 3.6535 (0.6); 3.6441 (0.8); 3.6371 (0.8); 3.6238 (0.9); 3.6075 (0.7); 3.3135 (89.5); 3.2626 (0.7); 2.6698 (0.7); 2.5232 (1.8); 2.5185 (2.5); 2.5099 (41.1); 2.5053 (91.2); 2.5007 (127.6); 2.4960 (88.7); 2.4915 (40.6); 2.4804 (1.6); 2.4699 (1.5); 2.4579 (2.5); 2.4509 (1.2); 2.4461 (1.9); 2.4012 (0.5); 2.3799 (0.6); 2.3589 (1.4); 2.3365 (1.5); 2.3274 (0.9); 2.3227 (0.7); 2.3174 (1.3); 2.2917 (0.7); 2.2866 (0.7); 2.2784 (0.8); 2.2733 (0.9); 2.2679 (1.0); 2.2626 (1.0); 2.2544 (1.0); 2.2495 (1.2); 2.2259 (0.5); 2.2206 (0.6); 2.2126 (0.5); 2.1874 (1.3); 2.1837 (1.4); 2.1660 (1.4); 2.1624 (1.4); 2.1530 (1.2); 2.1491 (1.2); 2.1315 (1.2); 2.1274 (1.7); 2.1138 (0.7); 2.1020 (0.9); 2.0945 (1.2); 2.0707 (0.9); 1.7666 (0.5); 1.7585 (0.7); 1.7534 (0.7); 1.7453 (0.8); 1.7270 (0.7); 1.7217 (0.6); 1.3839 (0.8); 1.3651 (2.8); 1.3583 (1.2); 1.3467 (3.4); 1.3400 (1.8); 1.3299 (2.6); 1.3218 (1.3); 1.3116 (0.8); 0.9915 (16.0); 0.9749 (15.7); 0.8150 (4.3); 0.8118 (4.5); 0.7966 (9.0); 0.7934 (9.5); 0.7779 (3.8); 0.7747 (3.8); -0.0002 (12.0) I.1-215: 1 H-NMR (400.1 MHz, d6-DMSO): δ= 11.7858 (1.4); 7.4255 (0.6); 7.4043 (1.2); 7.3985 (0.6); 7.3832 (0.7); 7.3773 (1.2); 7.3562 (0.6); 7.2958 (0.5); 7.2907 (0.5); 7.2762 (0.5); 7.2708 (0.6); 7.2670 (0.6); 7.2616 (0.6); 7.2471 (0.5); 7.2420 (0.5); 7.0958 (0.6); 7.0915 (0.6); 7.0861 (0.6); 7.0807 (0.6); 7.0752 (0.5); 7.0700 (0.5); 7.0647 (0.5); 4.5877 (1.2); 4.5485 (1.4); 4.1494 (1.5); 4.1102 (1.2); 3.8330 (0.5); 3.8226 (0.6); 3.8123 (0.8); 3.8023 (0.6); 3.7919 (0.5); 3.3743 (0.8); 3.3232 (238.2); 3.2740 (1.2); 3.2174 (16.0); 2.7224 (0.9); 2.7114 (0.9); 2.6839 (1.2); 2.6729 (1.3); 2.6661 (0.4); 2.5238 (1.0); 2.5191 (1.4); 2.5104 (23.6); 2.5059 (51.0); 2.5014 (70.2); 2.4968 (49.8); 2.4924 (23.3); 2.4522 (0.3); 2.4134 (0.4); 2.4084 (0.4); 2.3899 (0.9); 2.3843 (1.2); 2.3714 (0.8); 2.3627 (1.3); 2.3462 (1.3); 2.3328 (0.4); 2.3240 (1.2); 2.3136 (0.6); 2.2999 (0.6); 2.2894 (0.8); 2.2759 (0.8); 2.2476 (0.4); 2.2347 (0.5); 2.2070 (0.3); 2.1883 (0.5); 2.1759 (0.4); 2.1693 (0.3); 2.1642 (0.4); 2.1569 (0.6); 2.1521 (0.4); 2.1374 (0.4); 2.1327 (0.4); 1.7440 (0.4); 1.7323 (0.5); 1.7216 (0.5); 1.7121 (0.5); 1.7006 (0.5); 1.6894 (0.3) I.1-216: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 10.8459 (3.1); 8.3318 (2.1); 8.3199 (2.3); 8.3119 (2.4); 8.3003 (2.0); 7.5429 (4.2); 7.5234 (4.5); 7.3425 (4.4); 7.3242 (4.7); 7.3223 (5.1); 7.1327 (8.3); 7.1148 (6.8); 7.0912 (8.1); 7.0857 (5.9); 7.0798 (6.5); 7.0708 (5.3); 7.0681 (5.4); 7.0475 (2.8); 7.0446 (2.2); 7.0064 (5.3); 6.9972 (3.9); 6.9945 (3.2); 6.9865 (4.0); 6.9797 (4.2); 6.9774 (4.5); 6.9599 (2.1); 6.9573 (1.6); 4.6282 (2.0); 4.5910 (2.6); 4.5590 (2.0); 4.5299 (0.7); 4.5176 (0.9); 4.5069 (1.6); 4.4945 (1.7); 4.4866 (1.6); 4.4742 (1.6); 4.4633 (0.8); 4.4511 (0.6); 4.0140 (2.3); 3.9760 (2.1); 3.8852 (2.2); 3.8468 (2.1); 3.6247 (2.2); 3.6155 (2.6); 3.6061 (2.6); 3.4574 (1.8); 3.3587 (85.4); 3.1993 (1.8); 3.1872 (1.9); 3.1628 (2.5); 3.1513 (2.2); 3.0152 (1.7); 3.0083 (1.8); 2.9923 (1.8); 2.9850 (2.0); 2.9716 (1.5); 2.9560 (1.4); 2.9487 (1.4); 2.6821 (1.3); 2.6777 (1.2); 2.6125 (1.2); 2.5696 (1.3); 2.5653 (1.3); 2.5607 (1.2); 2.5218 (28.5); 2.5176 (57.4); 2.5131 (77.1); 2.5087 (60.2); 2.4910 (2.6); 2.4852 (2.5); 2.4729 (2.3); 2.4679 (2.6); 2.4569 (2.1); 2.3444 (0.8); 2.3398 (0.9); 2.3355 (0.8); 2.3233 (0.8); 2.3017 (1.5); 2.2754 (16.0); 2.2670 (14.9); 2.2391 (2.2); 2.2173 (1.2); 2.2049 (1.0); 2.1911 (1.3); 2.1863 (1.4); 2.1809 (1.5); 2.1631 (2.8); 2.1484 (1.8); 2.1386 (2.7); 2.1301 (2.0); 2.1154 (1.9); 2.1066 (2.1); 2.0968 (1.2); 2.0809 (1.3); 1.9159 (0.7); 1.9036 (0.6); 1.8926 (0.8); 1.8842 (0.9); 1.8604 (0.8); 1.7975 (0.7); 1.7855 (0.6); 1.7741 (0.8); 1.7661 (0.9); 1.7548 (0.5); 1.7423 (0.8); 1.6739 (0.6); 1.6635 (0.8); 1.6528 (0.8); 1.6410 (0.8); 1.6316 (0.6); 1.4291 (0.6); 1.4184 (0.8); 1.4079 (0.8); 1.3959 (0.8); 1.3863 (0.7) I.1-217: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.2307 (0.7); 7.2119 (1.7); 7.1932 (1.1); 7.0820 (0.9); 7.0633 (0.7); 7.0176 (1.5); 6.9864 (0.7); 4.6545 (1.1); 4.6165 (1.2); 4.0623 (1.2); 4.0238 (1.0); 3.7354 (0.6); 3.7251 (0.6); 3.7148 (0.6); 3.5531 (16.0); 3.3851 (15.2); 3.1671 (0.5); 2.7551 (0.8); 2.7448 (0.9); 2.7152 (1.1); 2.7049 (1.0); 2.6787 (0.6); 2.6742 (1.2); 2.6697 (1.7); 2.6651 (1.2); 2.5554 (0.6); 2.5506 (0.8); 2.5459 (0.6); 2.5404 (0.6); 2.5231 (4.7); 2.5184 (7.2); 2.5098 (95.0); 2.5052 (203.8); 2.5006 (283.6); 2.4960 (198.0); 2.4914 (87.9); 2.4599 (1.4); 2.4380 (1.2); 2.4202 (1.1); 2.4050 (0.7); 2.3981 (1.1); 2.3855 (0.5); 2.3625 (0.6); 2.3367 (0.6); 2.3320 (1.3); 2.3274 (1.8); 2.3227 (1.3); 2.3009 (0.6); 2.2845 (8.5); 2.2769 (1.2); 2.2633 (0.8); 2.1330 (0.5); 1.7031 (0.5); 0.0080 (4.1); -0.0002 (142.6); -0.0086 (4.3) I.1-218: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.3802 (0.8); 7.3589 (1.0); 7.2565 (0.8); 7.2352 (0.6); 3.5497 (0.5); 3.4606 (16.0); 3.1678 (0.7); 2.5230 (1.1); 2.5182 (1.5); 2.5096 (21.0); 2.5050 (44.9); 2.5003 (61.6); 2.4957 (42.8); 2.4911 (19.2); 2.0719 (0.5); -0.0002 (6.9) I.1-220: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.2646 (2.0); 8.2447 (2.0); 7.2287 (1.8); 7.2244 (2.1); 7.2142 (4.7); 7.2107 (6.7); 7.1978 (1.0); 7.1749 (1.1); 7.1689 (1.0); 7.1561 (2.2); 7.1491 (2.0); 7.1421 (1.5); 7.1350 (2.1); 7.1305 (2.8); 7.1274 (3.0); 7.1096 (1.1); 4.7649 (2.4); 4.7258 (2.7); 4.1878 (0.7); 4.1726 (0.9); 4.1677 (1.0); 4.1525 (1.2); 4.1456 (0.8); 4.1303 (0.8); 4.0616 (2.3); 4.0225 (2.1); 3.6751 (0.7); 3.6538 (1.2); 3.6323 (0.8); 3.6231 (0.6); 3.4737 (3.5); 3.1671 (4.5); 2.6753 (0.8); 2.6707 (1.1); 2.6661 (0.8); 2.6280 (1.0); 2.6094 (3.0); 2.6053 (3.0); 2.5904 (3.0); 2.5865 (3.1); 2.5729 (1.9); 2.5680 (1.8); 2.5641 (1.8); 2.5409 (0.8); 2.5282 (1.1); 2.5241 (2.4); 2.5195 (4.0); 2.5107 (60.6); 2.5062 (132.6); 2.5016 (185.3); 2.4970 (131.7); 2.4925 (59.6); 2.4777 (2.1); 2.4730 (2.5); 2.4684 (2.6); 2.4637 (1.8); 2.4519 (1.2); 2.4471 (0.8); 2.4158 (1.0); 2.3957 (0.9); 2.3739 (1.6); 2.3507 (0.8); 2.3330 (0.8); 2.3284 (1.2); 2.3238 (0.8); 2.2908 (0.9); 2.2807 (1.0); 2.2669 (1.2); 2.2565 (1.3); 2.2493 (0.8); 2.2380 (2.1); 2.2249 (0.8); 2.2142 (2.1); 2.2035 (1.4); 2.1796 (1.3); 2.0753 (0.6); 2.0400 (0.7); 2.0312 (0.6); 2.0189 (0.8); 2.0082 (1.0); 1.9876 (0.9); 1.8408 (0.7); 1.8325 (0.6); 1.8276 (0.6); 1.8185 (1.0); 1.8087 (1.0); 1.8000 (0.5); 1.7867 (0.5); 1.6149 (0.6); 1.5949 (0.8); 1.5788 (0.8); 1.5626 (0.6); 1.5055 (1.5); 1.4974 (1.8); 1.4929 (1.5); 1.4825 (2.8); 1.4752 (1.4); 1.4690 (1.4); 1.4610 (1.3); 1.1430 (7.0); 1.1242 (16.0); 1.1053 (6.9); 0.8940 (10.2); 0.8777 (9.9); 0.8258 (10.3); 0.8096 (10.1); 0.0080 (0.7); -0.0002 (24.4); -0.0086 (0.8) I.1-222: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.8299 (5.8); 7.2391 (0.9); 7.2204 (2.2); 7.2016 (1.4); 7.0863 (1.5); 7.0669 (1.2); 7.0496 (2.0); 7.0377 (1.4); 7.0169 (1.4); 4.7144 (1.2); 4.6758 (1.3); 4.0840 (1.4); 4.0455 (1.3); 3.8412 (0.6); 3.8307 (0.7); 3.8190 (0.8); 3.8091 (0.7); 3.7989 (0.6); 3.5921 (16.0); 2.8641 (0.5); 2.8543 (0.5); 2.8273 (0.7); 2.8175 (0.6); 2.7662 (2.0); 2.7539 (2.0); 2.5236 (0.5); 2.5189 (0.9); 2.5102 (17.6); 2.5057 (38.7); 2.5011 (54.4); 2.4965 (39.0); 2.4919 (18.3); 2.4683 (1.0); 2.4647 (1.0); 2.4512 (0.5); 2.4433 (1.0); 2.4210 (0.9); 2.4020 (0.8); 2.3978 (0.8); 2.3790 (0.7); 2.3325 (0.8); 2.3280 (0.5); 2.3190 (0.8); 2.3082 (0.9); 2.2875 (12.1); 2.2664 (0.6); 2.2534 (0.6); 2.1821 (0.6); 2.1580 (0.6); 2.1509 (0.7); 2.1458 (0.5); 2.1264 (0.6); 2.0732 (1.3); 1.8203 (0.6); 1.8104 (0.5); 1.7996 (0.6); 1.7887 (0.6); 1.7778 (0.5); 1.0710 (0.8); 1.0530 (1.7); 1.0350 (0.7); 0.0080 (0.5); -0.0002 (17.6); -0.0085 (0.6) I.1-225: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 10.7955 (4.3); 8.0700 (2.2); 8.0560 (4.4); 8.0419 (2.1); 7.5174 (6.1); 7.4975 (6.5); 7.3808 (1.2); 7.3768 (1.3); 7.3603 (2.6); 7.3563 (2.9); 7.3502 (1.7); 7.3358 (10.9); 7.3338 (8.2); 7.3179 (6.5); 7.3157 (10.7); 7.3135 (7.3); 7.2085 (1.5); 7.2046 (1.7); 7.1958 (1.7); 7.1918 (2.0); 7.1885 (2.9); 7.1849 (3.1); 7.1757 (2.8); 7.1724 (3.2); 7.1683 (2.0); 7.1644 (1.9); 7.1555 (1.6); 7.1519 (1.7); 7.1238 (9.0); 7.1181 (8.7); 7.0747 (5.0); 7.0718 (6.0); 7.0571 (7.9); 7.0545 (11.1); 7.0519 (7.4); 7.0371 (6.2); 7.0343 (6.2); 6.9827 (5.5); 6.9800 (5.8); 6.9651 (5.0); 6.9628 (8.4); 6.9604 (6.2); 6.9455 (3.9); 6.9429 (3.7); 4.7400 (4.5); 4.7002 (5.2); 4.2323 (5.6); 4.1926 (4.9); 3.8159 (0.9); 3.8051 (1.8); 3.7946 (2.6); 3.7845 (3.3); 3.7745 (2.6); 3.7641 (1.8); 3.7534 (0.9); 3.4882 (16.0); 3.3360 (2.3); 3.3204 (5.3); 3.3028 (5.5); 3.2865 (2.8); 3.1700 (0.5); 2.8030 (5.9); 2.7837 (8.9); 2.7663 (5.1); 2.6704 (0.5); 2.5405 (0.6); 2.5190 (5.3); 2.5104 (30.4); 2.5059 (66.3); 2.5012 (90.3); 2.4966 (62.8); 2.4920 (28.2); 2.4843 (5.1); 2.4726 (4.3); 2.3874 (1.0); 2.3675 (1.5); 2.3644 (1.5); 2.3450 (3.2); 2.3256 (3.2); 2.3028 (2.5); 2.2718 (2.4); 2.2584 (2.9); 2.2477 (3.6); 2.2344 (3.5); 2.2166 (1.4); 2.2058 (2.1); 2.1980 (4.8); 2.1928 (2.4); 2.1765 (4.4); 2.1631 (3.8); 2.1416 (3.7); 2.1179 (1.2); 2.0984 (2.2); 2.0941 (1.4); 2.0862 (1.7); 2.0791 (1.5); 2.0744 (2.2); 2.0668 (2.7); 2.0623 (1.7); 2.0551 (1.0); 2.0472 (1.5); 2.0428 (2.1); 2.0232 (0.9); 1.7426 (1.2); 1.7299 (1.7); 1.7191 (2.4); 1.7089 (2.1); 1.6975 (2.1); 1.6872 (2.1); 1.6767 (1.2); 1.6636 (0.9); -0.0002 (8.2) I.1-226: 1 H-NMR (400.1 MHz, d 6 -DMSO): δ= 12.3354 (1.1); 7.6245 (15.2); 7.6192 (16.0); 7.4172 (6.9); 7.4119 (6.6); 7.3964 (9.3); 7.3911 (9.1); 7.2838 (13.5); 7.2629 (10.0); 4.6530 (8.3); 4.6123 (10.0); 4.2473 (9.3); 4.2065 (7.8); 3.8069 (1.2); 3.7965 (2.4); 3.7861 (3.7); 3.7762 (4.2); 3.7658 (3.8); 3.7554 (3.0); 3.7449 (1.1); 3.3368 (8.3); 2.6737 (0.3); 2.6690 (0.4); 2.6569 (5.2); 2.6465 (5.3); 2.6170 (7.0); 2.6067 (6.7); 2.5393 (0.4); 2.5224 (0.9); 2.5091 (19.8); 2.5047 (41.9); 2.5002 (58.2); 2.4957 (42.5); 2.4912 (20.6); 2.4688 (1.8); 2.4512 (1.9); 2.4410 (1.2); 2.4276 (4.6); 2.4115 (9.9); 2.4046 (3.8); 2.3899 (8.3); 2.3719 (5.8); 2.3500 (5.3); 2.3315 (0.4); 2.3270 (0.5); 2.3135 (2.5); 2.3011 (2.6); 2.2891 (4.5); 2.2768 (4.7); 2.2486 (8.4); 2.2391 (5.2); 2.2303 (2.8); 2.2247 (2.2); 2.2194 (1.2); 2.2123 (3.6); 2.2063 (1.6); 2.2003 (1.1); 2.1931 (2.0); 2.1876 (2.0); 2.1688 (1.0); 1.8062 (0.9); 1.7824 (3.3); 1.7715 (2.9); 1.7611 (3.2); 1.7536 (2.0); 1.7482 (2.0); 1.7447 (2.0); 1.7403 (2.2); 1.7290 (2.2); 1.7171 (1.2); 1.3514 (0.4); 1.2279 (0.4) I.1-227: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.1473 (2.0); 7.1271 (7.0); 7.1106 (7.6); 7.0901 (2.1); 4.7989 (0.7); 4.7851 (0.9); 4.7719 (0.7); 4.7664 (0.5); 4.6675 (1.9); 4.6293 (2.1); 4.0466 (1.9); 4.0084 (1.7); 3.7115 (0.6); 3.7012 (0.8); 3.6906 (1.0); 3.6801 (0.8); 3.6698 (0.6); 3.3933 (63.2); 2.7348 (0.8); 2.7251 (1.6); 2.7156 (0.8); 2.6957 (1.1); 2.6861 (1.9); 2.6766 (1.2); 2.5251 (0.8); 2.5204 (1.1); 2.5117 (18.1); 2.5072 (38.7); 2.5026 (53.0); 2.4980 (37.8); 2.4935 (17.4); 2.4002 (1.2); 2.3932 (1.8); 2.3782 (1.5); 2.3712 (1.9); 2.3614 (1.0); 2.3541 (1.4); 2.3393 (1.0); 2.3320 (1.0); 2.2918 (0.7); 2.2757 (16.0); 2.2531 (1.1); 2.2277 (0.5); 2.2134 (0.5); 2.1460 (0.6); 2.1216 (0.5); 2.1144 (0.8); 2.0898 (0.5); 1.6948 (0.5); 1.6787 (0.6); 1.6710 (0.5); 1.6631 (0.6); 1.4761 (0.5); 1.4681 (0.5); 1.4584 (0.8); 1.4519 (0.7); 1.4436 (1.2); 1.4374 (0.6); 1.4340 (0.6); 1.4257 (1.1); 1.4192 (1.0); 1.4141 (0.6); 1.4109 (0.7); 1.4056 (1.0); 1.3918 (0.7); 1.3899 (0.7); 1.2766 (0.7); 1.2560 (1.2); 1.2377 (1.4); 1.2315 (0.7); 1.2208 (1.0); 1.2135 (0.7); 1.2040 (0.5); 1.1968 (0.6); 1.1231 (7.7); 1.1206 (7.7); 1.1075 (7.7); 1.1049 (7.6); 0.8620 (4.9); 0.8433 (9.4); 0.8253 (4.1); -0.0002 (9.6) I.1-228: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.1395 (2.1); 7.1193 (7.0); 7.1024 (7.8); 7.0819 (2.2); 4.6163 (2.0); 4.5785 (2.3); 4.0917 (2.2); 4.0538 (2.0); 3.7972 (0.7); 3.7867 (0.9); 3.7765 (1.1); 3.7666 (0.9); 3.7561 (0.7); 3.4312 (20.4); 3.3139 (0.6); 3.2974 (1.1); 3.2890 (0.9); 3.2801 (0.8); 3.2724 (1.6); 3.2551 (0.9); 3.2260 (1.8); 3.2092 (3.4); 3.1923 (1.7); 3.1714 (0.8); 3.1687 (0.9); 3.1548 (1.4); 3.1467 (0.6); 3.1381 (0.9); 3.1296 (1.0); 3.1129 (0.6); 2.6413 (1.1); 2.6305 (1.1); 2.6012 (1.4); 2.5904 (1.3); 2.5234 (0.7); 2.5186 (0.9); 2.5099 (18.2); 2.5054 (40.5); 2.5008 (57.2); 2.4962 (40.4); 2.4916 (18.5); 2.4228 (0.6); 2.4181 (0.6); 2.3998 (1.2); 2.3810 (0.9); 2.3766 (0.8); 2.3582 (0.8); 2.3278 (1.7); 2.3061 (1.4); 2.2879 (1.3); 2.2729 (16.0); 2.2498 (1.0); 2.2390 (1.3); 2.2254 (1.3); 2.2084 (0.5); 2.1973 (0.8); 2.1842 (0.8); 2.1235 (0.8); 2.1110 (0.6); 2.1050 (0.5); 2.0993 (0.6); 2.0922 (0.9); 2.0869 (0.5); 2.0719 (0.8); 2.0676 (0.7); 1.8212 (0.8); 1.8102 (1.2); 1.8047 (1.4); 1.7943 (1.6); 1.7868 (1.2); 1.7785 (1.3); 1.7627 (0.7); 1.7448 (1.1); 1.7287 (2.7); 1.7123 (2.9); 1.6953 (1.5); 1.6830 (0.6); 1.6716 (0.7); 1.6600 (0.8); 1.6484 (0.7); 1.6398 (0.7); 1.6281 (0.7); 1.6162 (0.5) I.1-230: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 7.9121 (1.0); 7.3525 (1.0); 7.3309 (1.0); 7.3270 (0.9); 7.3107 (0.5); 7.3069 (0.5); 7.2071 (0.6); 7.2031 (0.6); 7.1945 (0.6); 7.1904 (0.7); 7.1872 (1.1); 7.1833 (1.2); 7.1744 (1.0); 7.1708 (1.2); 7.1668 (0.7); 7.1627 (0.7); 7.1540 (0.6); 7.1503 (0.6); 7.0730 (1.1); 7.0570 (1.5); 7.0376 (0.8); 4.7349 (1.7); 4.6950 (2.0); 4.2353 (2.1); 4.1954 (1.8); 3.8054 (0.7); 3.7953 (0.9); 3.7849 (1.3); 3.7747 (1.0); 3.7645 (0.7); 3.3070 (72.1); 3.2566 (0.6); 3.1685 (0.5); 2.9992 (1.0); 2.9817 (2.1); 2.9677 (2.2); 2.9560 (2.0); 2.9386 (1.0); 2.6695 (0.6); 2.5229 (1.7); 2.5182 (2.4); 2.5095 (38.6); 2.5050 (84.7); 2.5003 (118.4); 2.4957 (83.3); 2.4911 (36.6); 2.4723 (2.1); 2.4604 (2.2); 2.4552 (0.8); 2.4505 (0.9); 2.4459 (0.6); 2.3803 (0.6); 2.3578 (1.2); 2.3361 (1.3); 2.3271 (0.8); 2.3224 (0.6); 2.3161 (1.1); 2.2858 (1.0); 2.2723 (1.2); 2.2617 (1.5); 2.2483 (1.5); 2.2305 (0.5); 2.2198 (0.8); 2.2066 (0.8); 2.1970 (1.9); 2.1758 (1.8); 2.1622 (1.6); 2.1465 (0.7); 2.1409 (1.6); 2.1272 (1.0); 2.1227 (0.6); 2.1149 (0.7); 2.1079 (0.6); 2.1032 (0.8); 2.0956 (1.1); 2.0910 (0.7); 2.0763 (0.6); 2.0714 (1.3); 1.7588 (0.7); 1.7478 (0.9); 1.7378 (0.7); 1.7268 (0.7); 1.7160 (0.8); 1.3962 (2.0); 1.3781 (4.1); 1.3600 (4.5); 1.3420 (2.4); 1.3239 (0.5); 0.8362 (7.6); 0.8178 (16.0); 0.7991 (6.7); -0.0002 (9.2) I.1-231: 1 H-NMR (400.1 MHz, d6-DMSO): δ= 7.1977 (1.4); 7.1491 (1.9); 7.1288 (7.5); 7.1153 (8.3); 7.0946 (2.1); 7.0660 (3.0); 6.9343 (1.6); 4.6390 (2.1); 4.6008 (2.3); 4.0280 (2.4); 3.9898 (2.2); 3.7637 (0.4); 3.7536 (0.8); 3.7429 (1.0); 3.7320 (1.2); 3.7218 (1.1); 3.7115 (0.8); 3.7012 (0.4); 2.8114 (1.3); 2.8013 (1.4); 2.7721 (1.6); 2.7620 (1.6); 2.5181 (0.4); 2.5094 (9.3); 2.5049 (21.4); 2.5002 (30.9); 2.4956 (23.0); 2.4911 (11.3); 2.4443 (1.5); 2.4312 (0.6); 2.4219 (1.6); 2.4053 (1.7); 2.3885 (1.3); 2.3828 (1.5); 2.3697 (1.0); 2.3662 (1.0); 2.3466 (0.8); 2.2778 (16.0); 2.2615 (1.4); 2.2484 (1.2); 2.2444 (0.7); 2.2311 (0.5); 2.2195 (0.7); 2.2068 (0.7); 2.1524 (0.4); 2.1330 (0.8); 2.1285 (0.5); 2.1204 (0.6); 2.1138 (0.6); 2.1087 (0.7); 2.1013 (0.9); 2.0966 (0.6); 2.0897 (0.4); 2.0817 (0.5); 2.0769 (0.7); 1.7193 (0.4); 1.7072 (0.6); 1.6960 (0.8); 1.6855 (0.8); 1.6748 (0.8); 1.6641 (0.8); 1.6527 (0.5); 1.6404 (0.3) I.1-233: 1 H-NMR (400.1 MHz, d6-DMSO): δ= 11.5146 (0.9); 7.3755 (0.8); 7.3571 (1.0); 7.3503 (0.4); 7.3458 (0.8); 7.3416 (0.6); 7.2944 (0.9); 7.2018 (0.6); 7.1838 (0.5); 4.6606 (0.6); 4.6216 (0.6); 4.1332 (0.6); 4.0941 (0.6); 3.3344 (37.3); 2.7738 (16.0); 2.7385 (0.4); 2.7282 (0.4); 2.7009 (0.5); 2.6906 (0.4); 2.5113 (4.0); 2.5068 (8.8); 2.5023 (12.3); 2.4977 (8.9); 2.4932 (4.2); 2.3972 (0.3); 2.3782 (0.3); 2.3718 (0.6); 2.3492 (0.5); 2.3339 (0.4); 2.3111 (0.5); 2.2985 (0.4); 2.2851 (0.3) I.1-235: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 7.7425 (0.7); 7.7236 (0.7); 7.1456 (1.4); 7.1251 (6.3); 7.1136 (7.1); 7.1077 (1.1); 7.0928 (1.5); 4.6667 (0.9); 4.6611 (0.9); 4.6289 (1.0); 4.6232 (1.0); 4.0300 (1.0); 4.0218 (1.0); 3.9919 (0.9); 3.9835 (0.9); 3.7081 (0.6); 3.6967 (0.7); 3.6855 (0.6); 3.6743 (0.6); 3.6475 (0.5); 3.6401 (0.5); 3.6309 (0.6); 3.6274 (0.6); 3.4529 (16.0); 2.5233 (0.6); 2.5186 (0.8); 2.5100 (13.0); 2.5054 (28.1); 2.5008 (39.0); 2.4962 (27.1); 2.4916 (12.3); 2.4821 (1.4); 2.4707 (0.7); 2.4593 (0.8); 2.4480 (1.4); 2.4367 (0.7); 2.3447 (0.9); 2.3264 (0.9); 2.3228 (0.9); 2.3026 (0.7); 2.2760 (13.0); 2.2588 (0.6); 2.2531 (0.6); 2.2488 (0.6); 2.2428 (0.6); 2.2347 (0.6); 2.2293 (0.6); 2.1058 (1.2); 2.0832 (1.2); 2.0716 (1.1); 2.0491 (1.1); 2.0120 (0.6); 1.3693 (1.4); 1.3583 (0.8); 1.3510 (2.1); 1.3401 (1.1); 1.3334 (1.6); 1.3219 (0.7); 0.9965 (5.6); 0.9935 (5.7); 0.9799 (5.6); 0.9770 (5.6); 0.8170 (2.6); 0.8128 (2.6); 0.7986 (5.4); 0.7944 (5.4); 0.7799 (2.3); 0.7758 (2.2) I.1-237: 1 H-NMR (400.0 MHz, CDCl3): δ= 7.2613 (34.4); 7.2290 (0.9); 7.2241 (0.6); 7.2157 (0.6); 7.2136 (0.6); 7.2087 (1.0); 7.2038 (0.6); 7.1954 (0.5); 7.1906 (0.6); 7.1692 (0.5); 7.1648 (0.6); 7.1505 (1.3); 7.1460 (1.3); 7.1316 (1.1); 7.1271 (0.9); 7.1122 (27.7); 7.0931 (1.8); 7.0900 (1.9); 7.0745 (1.8); 7.0715 (2.0); 7.0559 (0.7); 7.0529 (0.8); 7.0469 (1.0); 7.0442 (0.9); 7.0264 (0.8); 7.0220 (1.2); 7.0188 (1.0); 7.0010 (0.8); 6.9979 (0.8); 5.3879 (0.6); 5.2980 (0.5); 4.7028 (1.8); 4.6652 (2.0); 4.1193 (1.8); 4.0817 (1.6); 3.9358 (0.6); 3.9252 (0.8); 3.9150 (1.0); 3.9050 (0.8); 3.8944 (0.7); 3.5006 (0.8); 3.4833 (1.2); 3.4676 (1.1); 3.4609 (0.5); 3.4505 (0.6); 3.4438 (1.0); 3.4287 (1.1); 3.4116 (0.7); 2.8288 (1.5); 2.8117 (3.0); 2.7946 (1.4); 2.4989 (1.3); 2.4876 (1.5); 2.4693 (1.0); 2.4629 (1.5); 2.4514 (2.2); 2.4276 (0.8); 2.4127 (0.9); 2.3984 (1.0); 2.3884 (1.2); 2.3743 (1.2); 2.3700 (0.5); 2.3456 (0.6); 2.3315 (0.7); 2.3216 (16.0); 2.1912 (0.7); 2.1779 (0.5); 2.1670 (0.7); 2.1587 (0.8); 2.1538 (0.5); 2.1342 (0.7); 2.0678 (1.5); 2.0462 (1.5); 2.0317 (1.3); 2.0101 (1.3); 1.7343 (0.6); 1.7243 (0.6); 1.7115 (0.6); 1.7010 (0.5); -0.0002 (10.3) I.1-238: 1 H-NMR (400.0 MHz, CDCl3): δ= 7.5217 (1.2); 7.2627 (223.6); 7.2269 (2.2); 7.2106 (4.4); 7.2059 (3.8); 7.1942 (2.5); 7.1896 (8.4); 7.1850 (3.1); 7.1733 (3.8); 7.1687 (5.2); 7.1524 (2.5); 7.1168 (1.4); 7.1063 (2.2); 7.1022 (1.8); 7.0921 (5.0); 7.0800 (3.3); 7.0762 (3.6); 7.0735 (4.0); 7.0675 (7.0); 7.0601 (2.2); 7.0558 (3.2); 7.0486 (14.2); 7.0419 (12.2); 7.0380 (9.2); 7.0334 (16.0); 7.0250 (6.8); 7.0226 (5.7); 7.0129 (1.2); 7.0059 (1.1); 6.9987 (1.2); 6.9030 (1.2); 6.8986 (1.6); 6.8870 (10.5); 6.8780 (1.9); 6.8674 (14.1); 6.8566 (2.0); 6.8472 (9.2); 6.8352 (1.3); 6.8316 (1.0); 5.5095 (2.9); 5.2996 (0.8); 4.8468 (6.2); 4.8432 (6.2); 4.8080 (7.0); 4.8044 (7.0); 4.2270 (9.2); 4.1882 (8.1); 3.9262 (1.5); 3.9153 (3.1); 3.9041 (3.6); 3.8956 (3.8); 3.8926 (3.8); 3.8840 (3.6); 3.8727 (3.2); 3.8619 (1.5); 3.5525 (0.6); 3.5360 (1.6); 3.5189 (3.4); 3.5022 (7.1); 3.4859 (8.0); 3.4828 (8.0); 3.4669 (7.5); 3.4505 (3.3); 3.4330 (1.7); 3.4173 (0.6); 2.9016 (7.7); 2.8853 (14.6); 2.8689 (6.8); 2.5965 (6.4); 2.5860 (6.4); 2.5603 (7.4); 2.5498 (7.3); 2.5154 (1.3); 2.4954 (1.8); 2.4919 (1.7); 2.4716 (4.7); 2.4523 (4.2); 2.4490 (4.0); 2.4301 (3.9); 2.4118 (4.6); 2.3972 (5.4); 2.3876 (6.3); 2.3732 (6.4); 2.3689 (2.5); 2.3543 (2.0); 2.3446 (2.9); 2.3303 (2.9); 2.2516 (2.4); 2.2325 (3.8); 2.2276 (2.3); 2.2187 (2.9); 2.2135 (2.4); 2.2083 (3.2); 2.1998 (4.3); 2.1946 (2.8); 2.1895 (1.9); 2.1806 (2.6); 2.1754 (3.5); 2.1564 (1.8); 2.1158 (8.4); 2.0927 (8.3); 2.0797 (7.5); 2.0566 (7.4); 1.9860 (0.6); 1.8107 (2.2); 1.7994 (2.4); 1.7966 (2.8); 1.7858 (3.2); 1.7761 (3.1); 1.7728 (2.6); 1.7666 (2.5); 1.7632 (3.1); 1.7524 (2.8); 1.7429 (2.1); 1.7399 (1.9); 1.7284 (1.8); 0.0079 (1.8); -0.0002 (67.7); -0.0085 (2.2) I.1-240: 1 H-NMR (400.0 MHz, CDCl 3 ): δ= 7.2606 (70.3); 7.2152 (1.3); 7.1965 (3.2); 7.1777 (2.0); 7.1054 (0.6); 7.0917 (1.2); 7.0797 (0.7); 7.0733 (1.0); 7.0648 (1.9); 7.0596 (2.2); 7.0490 (1.5); 7.0456 (3.6); 7.0392 (3.8); 7.0357 (2.7); 7.0311 (4.0); 7.0222 (1.6); 6.9966 (0.6); 6.9864 (2.8); 6.9702 (1.7); 6.9512 (1.4); 5.3741 (0.8); 4.8420 (1.5); 4.8385 (1.6); 4.8033 (1.7); 4.7997 (1.7); 4.2253 (2.2); 4.1866 (2.0); 3.9306 (0.8); 3.9197 (0.9); 3.9091 (1.0); 3.8997 (0.9); 3.8887 (0.8); 3.5295 (0.9); 3.5123 (2.1); 3.4970 (3.3); 3.4817 (2.0); 3.4650 (1.0); 2.7739 (2.6); 2.7567 (5.3); 2.7395 (2.4); 2.5772 (1.6); 2.5663 (1.5); 2.5412 (1.8); 2.5303 (1.8); 2.4668 (1.2); 2.4475 (1.0); 2.4439 (1.0); 2.4244 (1.0); 2.4139 (1.2); 2.3992 (1.3); 2.3899 (1.6); 2.3754 (1.6); 2.3712 (0.6); 2.3469 (0.7); 2.3276 (16.0); 2.2669 (0.6); 2.2478 (1.0); 2.2431 (0.6); 2.2343 (0.7); 2.2288 (0.6); 2.2238 (0.8); 2.2152 (1.0); 2.2103 (0.6); 2.1961 (0.6); 2.1910 (0.8); 2.1057 (2.0); 2.0833 (1.9); 2.0697 (1.7); 2.0473 (1.7); 1.8160 (0.5); 1.8046 (0.6); 1.8019 (0.7); 1.7908 (0.8); 1.7813 (0.7); 1.7780 (0.6); 1.7719 (0.6); 1.7687 (0.7); 1.7576 (0.6); 1.7484 (0.5); 1.6474 (0.8); 0.0080 (0.6); -0.0002 (18.1) I.1-241: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 12.4940 (0.7); 8.2483 (1.5); 8.2290 (1.4); 7.1444 (1.4); 7.1238 (8.8); 7.1155 (9.5); 7.0943 (1.6); 4.6609 (1.9); 4.6224 (2.1); 4.1992 (0.6); 4.1848 (0.9); 4.1788 (0.8); 4.1652 (0.9); 4.1417 (0.6); 4.0209 (2.0); 3.9830 (1.7); 3.9090 (0.9); 3.6991 (0.7); 3.6883 (0.8); 3.6756 (0.9); 3.6657 (0.8); 3.6555 (0.6); 3.3532 (0.5); 3.3164 (53.5); 3.1634 (1.0); 2.6744 (1.3); 2.6698 (1.9); 2.6650 (1.4); 2.5717 (1.4); 2.5634 (1.4); 2.5445 (1.7); 2.5398 (3.0); 2.5302 (0.8); 2.5232 (3.4); 2.5185 (5.8); 2.5098 (100.7); 2.5053 (223.1); 2.5006 (314.6); 2.4960 (219.7); 2.4914 (98.4); 2.4731 (2.3); 2.4685 (1.6); 2.3743 (0.6); 2.3542 (1.0); 2.3321 (2.2); 2.3275 (2.1); 2.3229 (1.5); 2.3114 (0.9); 2.2760 (16.0); 2.2567 (1.1); 2.2461 (1.2); 2.2328 (1.1); 2.2151 (0.6); 2.2040 (0.6); 2.1911 (0.6); 2.1751 (1.4); 2.1517 (1.4); 2.1409 (1.2); 2.1175 (1.3); 2.0732 (0.9); 2.0226 (0.7); 1.9989 (0.7); 1.9910 (0.9); 1.9662 (0.7); 1.7716 (0.5); 1.7611 (0.9); 1.7515 (0.7); 1.7388 (0.7); 1.7288 (0.6); 1.5957 (0.7); 1.5803 (0.6); 1.5107 (1.3); 1.4987 (2.0); 1.4846 (1.9); 1.4751 (1.4); 1.4624 (1.1); 0.8937 (9.3); 0.8773 (8.9); 0.8285 (9.1); 0.8123 (9.0); 0.0081 (3.5); -0.0002 (129.9); -0.0085 (3.5); -0.0330 (0.6) I.1-242: 1 H-NMR (400.1 MHz, d 6 -DMSO): δ= 11.4782 (1.1); 7.3908 (0.5); 7.3752 (0.5); 7.3557 (0.4); 7.0906 (0.5); 7.0813 (0.8); 7.0606 (1.0); 7.0303 (0.5); 4.6714 (0.7); 4.6321 (0.8); 4.1460 (0.8); 4.1067 (0.7); 3.7890 (0.3); 3.7780 (0.4); 3.7682 (0.3); 3.3164 (8.6); 2.7726 (16.0); 2.7288 (0.5); 2.7184 (0.5); 2.6912 (0.5); 2.6808 (0.5); 2.5089 (5.5); 2.5046 (11.8); 2.5001 (16.5); 2.4957 (12.6); 2.3955 (0.4); 2.3744 (0.9); 2.3524 (0.8); 2.3368 (0.5); 2.3222 (0.4); 2.3146 (0.5); 2.3089 (0.4); 2.2979 (0.4); 2.2843 (0.4); 2.0709 (0.8); 0.0000 (2.7) I.1-243: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.9112 (1.8); 8.8898 (1.9); 7.3503 (1.2); 7.3480 (2.0); 7.3436 (1.9); 7.3412 (2.2); 7.3375 (1.4); 7.3298 (3.8); 7.3273 (5.4); 7.3230 (3.7); 7.3206 (4.5); 7.3112 (5.2); 7.3045 (4.5); 7.2638 (9.0); 7.2540 (8.7); 7.2458 (6.3); 7.2360 (5.9); 7.2274 (1.4); 7.2238 (0.6); 7.2206 (0.6); 7.2170 (0.9); 7.1155 (2.5); 7.0956 (6.7); 7.0737 (7.6); 7.0532 (2.7); 6.1145 (2.3); 6.0931 (2.3); 4.6523 (1.9); 4.6143 (2.1); 3.9910 (2.2); 3.9531 (2.0); 3.7351 (0.7); 3.7243 (0.9); 3.7140 (1.1); 3.7041 (0.9); 3.6934 (0.7); 3.3257 (17.3); 2.6441 (1.3); 2.6330 (1.3); 2.6095 (1.6); 2.5983 (1.5); 2.5088 (6.6); 2.5042 (14.3); 2.4996 (20.0); 2.4950 (14.0); 2.4904 (6.2); 2.3525 (0.5); 2.3332 (1.2); 2.3216 (1.8); 2.3146 (1.1); 2.3105 (1.1); 2.2994 (1.7); 2.2870 (1.6); 2.2620 (16.0); 2.2437 (1.2); 2.2333 (1.2); 2.2196 (1.2); 2.2159 (0.7); 2.2019 (0.6); 2.1915 (0.6); 2.1779 (0.6); 2.0712 (8.4); 2.0254 (0.7); 2.0209 (0.5); 2.0129 (0.6); 2.0062 (0.5); 2.0012 (0.7); 1.9938 (0.9); 1.9890 (0.6); 1.9743 (0.5); 1.9696 (0.7); 1.7253 (0.6); 1.7146 (0.8); 1.7042 (0.7); 1.6930 (0.7); 1.6826 (0.7); -0.0002 (2.4) I.1-244: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.4244 (0.9); 7.4068 (2.3); 7.3879 (2.0); 7.3624 (0.8); 7.3457 (0.7); 7.1934 (3.6); 7.1896 (5.3); 7.1844 (1.2); 7.1722 (3.6); 7.0930 (2.1); 7.0743 (2.6); 6.9680 (1.6); 6.9504 (1.3); 4.4167 (0.6); 4.3796 (0.6); 3.9338 (0.7); 3.8984 (0.6); 3.7518 (0.8); 3.7417 (0.7); 3.3198 (103.0); 3.1682 (0.5); 3.1079 (4.8); 2.6697 (0.6); 2.5231 (1.2); 2.5184 (1.8); 2.5098 (33.4); 2.5052 (72.9); 2.5006 (102.3); 2.4960 (71.7); 2.4914 (32.4); 2.4499 (0.6); 2.4391 (0.6); 2.4036 (0.6); 2.3273 (0.6); 2.2819 (16.0); 2.1961 (1.2); 2.1814 (0.9); 2.1029 (0.6); 2.0827 (0.6); 2.0719 (0.9); 2.0505 (0.5); -0.0002 (0.6) I.1-246: 1 H-NMR (400.1 MHz, CDCl3): δ= 7.5201 (0.5); 7.5182 (0.5); 7.2613 (82.2); 7.2593 (80.8); 7.1275 (0.4); 7.1150 (0.9); 7.1029 (1.6); 7.0924 (1.1); 7.0849 (1.7); 7.0782 (1.7); 7.0692 (1.0); 7.0590 (6.4); 7.0487 (6.1); 7.0412 (2.1); 7.0363 (2.0); 6.9974 (0.5); 6.9955 (0.4); 4.8980 (2.5); 4.8595 (2.8); 4.7241 (1.1); 4.7131 (1.2); 4.6968 (2.2); 4.6859 (2.3); 4.6695 (1.2); 4.6584 (1.1); 4.2514 (3.7); 4.2126 (3.3); 3.9077 (0.5); 3.8965 (1.0); 3.8858 (1.5); 3.8754 (1.6); 3.8648 (1.5); 3.8541 (1.1); 3.8429 (0.6); 2.7495 (2.2); 2.7398 (2.2); 2.7112 (2.7); 2.7015 (2.7); 2.5585 (0.6); 2.5411 (0.8); 2.5341 (0.7); 2.5159 (1.9); 2.4981 (1.6); 2.4915 (1.5); 2.4741 (1.6); 2.4425 (1.3); 2.4272 (1.5); 2.4181 (1.9); 2.4021 (2.0); 2.3846 (3.2); 2.3752 (1.1); 2.3608 (3.5); 2.3463 (2.3); 2.3235 (2.2); 2.3064 (0.8); 2.2875 (1.2); 2.2730 (0.9); 2.2631 (0.9); 2.2549 (1.4); 2.2497 (0.9); 2.2355 (0.8); 2.2304 (1.0); 2.2121 (0.5); 1.9448 (1.3); 1.9154 (1.4); 1.8476 (0.7); 1.8342 (1.1); 1.8219 (1.5); 1.8098 (2.0); 1.8019 (2.0); 1.7911 (2.1); 1.7865 (1.9); 1.7754 (1.6); 1.7675 (1.2); 1.7571 (0.5); 1.7505 (0.5); 1.6912 (2.6); 1.6831 (2.1); 1.6643 (2.6); 1.6578 (2.6); 1.6497 (1.8); 1.6427 (0.7); 1.5553 (22.8); 1.5209 (0.3); 1.5111 (0.5); 1.5035 (0.5); 1.4900 (0.8); 1.4812 (0.9); 1.4736 (0.9); 1.4656 (1.0); 1.4578 (0.8); 1.4521 (0.7); 1.4440 (0.6); 1.4360 (0.5); 1.4274 (0.3); 1.3865 (0.6); 1.3789 (0.9); 1.3719 (0.6); 1.3496 (1.6); 1.3283 (0.7); 1.3210 (1.1); 1.3135 (0.6); 1.0953 (0.4); 1.0847 (0.6); 1.0590 (1.2); 1.0531 (1.3); 1.0281 (1.6); 1.0203 (1.3); 0.9964 (0.6); 0.9885 (0.6); 0.9779 (1.2); 0.9484 (2.9); 0.9192 (3.1); 0.9095 (15.0); 0.9013 (16.0); 0.8933 (15.0); 0.8839 (14.6); 0.8685 (1.8); 0.8448 (1.2); 0.8137 (0.5); 0.7498 (14.3); 0.7324 (14.0); 0.0061 (1.3) I.1-247: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.5979 (0.5); 8.5851 (0.7); 8.5706 (8.8); 8.5685 (10.2); 8.5664 (10.6); 8.5642 (9.4); 8.5582 (9.3); 8.5560 (10.7); 8.5540 (10.4); 8.5517 (9.2); 7.8983 (6.0); 7.8939 (6.1); 7.8790 (11.7); 7.8746 (11.8); 7.8597 (6.9); 7.8553 (6.8); 7.4494 (0.6); 7.4385 (0.5); 7.3955 (7.4); 7.3829 (7.9); 7.3792 (7.0); 7.3767 (7.0); 7.3632 (13.9); 7.3610 (14.2); 7.3411 (12.3); 7.3229 (0.5); 4.7555 (13.4); 4.7150 (16.0); 4.4884 (0.6); 4.4732 (0.6); 4.4305 (1.2); 4.4222 (1.6); 4.4075 (1.1); 4.3904 (1.2); 4.3759 (1.2); 4.3253 (15.0); 4.2848 (13.0); 4.2337 (1.3); 4.1082 (1.6); 3.9353 (1.1); 3.9247 (1.1); 3.9144 (1.0); 3.8991 (2.8); 3.8885 (4.2); 3.8770 (5.9); 3.8692 (5.7); 3.8665 (5.8); 3.8579 (5.8); 3.8471 (4.6); 3.8360 (2.3); 3.1686 (0.7); 2.9967 (0.5); 2.7230 (9.6); 2.7129 (9.9); 2.6832 (12.2); 2.6731 (12.2); 2.5249 (1.3); 2.5201 (2.1); 2.5115 (41.0); 2.5069 (90.2); 2.5023 (127.1); 2.4977 (90.3); 2.4931 (41.2); 2.4617 (0.7); 2.4570 (1.1); 2.4518 (3.2); 2.4434 (1.1); 2.4352 (3.4); 2.4210 (1.5); 2.4104 (7.8); 2.3918 (16.2); 2.3870 (7.2); 2.3744 (3.4); 2.3693 (12.7); 2.3599 (2.8); 2.3521 (11.3); 2.3295 (11.0); 2.3199 (0.9); 2.3110 (4.8); 2.2974 (4.6); 2.2867 (9.4); 2.2734 (9.2); 2.2471 (12.7); 2.2396 (6.9); 2.2379 (6.8); 2.2331 (5.6); 2.2290 (4.2); 2.2234 (2.1); 2.2170 (4.9); 2.2149 (4.6); 2.2088 (2.4); 2.2046 (2.0); 2.1978 (3.6); 2.1927 (2.5); 2.1905 (2.7); 2.1734 (1.9); 1.7883 (1.5); 1.7830 (0.9); 1.7647 (3.3); 1.7614 (3.9); 1.7534 (5.7); 1.7475 (3.5); 1.7422 (4.2); 1.7358 (3.0); 1.7284 (4.2); 1.7237 (4.0); 1.7112 (3.7); 1.6980 (2.2); 0.0080 (0.5); -0.0002 (18.6); -0.0086 (0.6) I.1-248: 1 H-NMR (400.0 MHz, CDCl3): δ= 7.5212 (1.0); 7.3558 (5.6); 7.3360 (11.8); 7.3162 (7.9); 7.2729 (0.6); 7.2721 (0.7); 7.2713 (0.7); 7.2705 (0.8); 7.2697 (0.9); 7.2680 (1.4); 7.2622 (188.6); 7.1213 (6.8); 7.1103 (5.7); 7.1037 (9.1); 7.0965 (5.2); 7.0869 (5.2); 7.0840 (5.7); 7.0807 (4.5); 7.0779 (3.6); 7.0703 (4.9); 7.0640 (1.6); 7.0588 (2.0); 7.0535 (4.5); 7.0509 (9.6); 7.0440 (9.0); 7.0406 (7.1); 7.0359 (12.4); 7.0273 (6.4); 7.0248 (7.3); 7.0171 (7.6); 6.9982 (1.1); 5.4464 (2.4); 4.8443 (4.8); 4.8407 (4.8); 4.8056 (5.4); 4.8019 (5.4); 4.2387 (6.9); 4.1999 (6.2); 3.9469 (1.1); 3.9358 (2.3); 3.9250 (2.9); 3.9148 (3.2); 3.9049 (2.9); 3.8939 (2.4); 3.8829 (1.2); 3.5743 (0.6); 3.5566 (1.4); 3.5403 (3.0); 3.5226 (5.6); 3.5175 (2.6); 3.5074 (5.4); 3.5049 (4.1); 3.5002 (5.3); 3.4898 (2.9); 3.4851 (5.5); 3.4680 (3.0); 3.4510 (1.3); 3.4338 (0.6); 2.8432 (8.2); 2.8258 (16.0); 2.8083 (7.3); 2.5915 (4.9); 2.5806 (4.9); 2.5553 (5.7); 2.5444 (5.6); 2.5163 (1.0); 2.4963 (1.3); 2.4931 (1.2); 2.4734 (3.5); 2.4534 (3.2); 2.4500 (3.1); 2.4304 (3.1); 2.4201 (3.6); 2.4053 (4.2); 2.3960 (5.0); 2.3814 (5.0); 2.3773 (1.8); 2.3625 (1.4); 2.3530 (2.2); 2.3386 (2.1); 2.2718 (1.9); 2.2527 (2.9); 2.2480 (1.8); 2.2392 (2.3); 2.2338 (1.8); 2.2287 (2.4); 2.2203 (3.2); 2.2152 (2.1); 2.2098 (1.4); 2.2011 (2.0); 2.1959 (2.5); 2.1769 (1.3); 2.1280 (6.3); 2.1056 (6.2); 2.0918 (5.6); 2.0695 (5.6); 2.0061 (0.6); 1.8106 (1.6); 1.7992 (1.8); 1.7964 (2.1); 1.7852 (2.2); 1.7758 (2.2); 1.7727 (1.9); 1.7665 (1.9); 1.7633 (2.3); 1.7543 (1.7); 1.7520 (2.0); 1.7430 (1.6); 1.7399 (1.5); 1.7283 (1.3); 0.0080 (1.6); 0.0048 (0.6); -0.0002 (55.5); -0.0085 (1.6) I.1-250: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 7.9170 (2.3); 7.9128 (14.2); 7.9084 (4.8); 7.8964 (5.1); 7.8919 (16.0); 7.8877 (2.7); 7.8806 (0.7); 7.3502 (12.4); 7.3293 (11.6); 4.7296 (4.9); 4.6899 (5.6); 4.2365 (5.5); 4.1969 (4.8); 3.7626 (1.0); 3.7519 (1.7); 3.7410 (2.4); 3.7321 (2.4); 3.7207 (2.4); 3.7101 (1.9); 3.6995 (1.0); 2.6818 (3.6); 2.6718 (4.1); 2.6420 (4.6); 2.6321 (4.2); 2.5252 (0.7); 2.5204 (1.1); 2.5118 (17.4); 2.5072 (37.1); 2.5026 (51.4); 2.4979 (36.8); 2.4934 (17.1); 2.4640 (1.2); 2.4461 (1.1); 2.4394 (1.2); 2.4224 (2.8); 2.4047 (2.2); 2.3988 (2.0); 2.3817 (1.8); 2.3410 (4.7); 2.3293 (0.7); 2.3185 (5.4); 2.3068 (2.4); 2.3012 (4.4); 2.2965 (3.3); 2.2822 (3.5); 2.2787 (5.2); 2.2659 (0.8); 2.2547 (1.8); 2.2418 (2.0); 2.2269 (1.3); 2.2086 (1.7); 2.2028 (0.9); 2.1963 (1.5); 2.1909 (1.3); 2.1840 (1.3); 2.1784 (2.0); 2.1722 (1.3); 2.1666 (0.9); 2.1591 (1.3); 2.1536 (1.3); 2.1348 (0.7); 1.7550 (0.9); 1.7431 (1.5); 1.7317 (1.9); 1.7240 (1.4); 1.7208 (1.6); 1.7124 (1.8); 1.7072 (1.3); 1.7001 (1.8); 1.6888 (1.2); 1.6754 (0.8); 0.0081 (0.6); -0.0002 (19.7); -0.0085 (0.6) I.1-251: 1 H-NMR (400.0 MHz, CDCl3): δ= 7.3710 (3.4); 7.3505 (3.7); 7.2618 (34.8); 7.2403 (2.7); 7.2351 (2.8); 7.1164 (29.3); 7.0003 (1.6); 6.9951 (1.6); 6.9798 (1.4); 6.9746 (1.4); 5.3852 (0.6); 5.2987 (1.1); 4.6996 (1.8); 4.6620 (2.0); 4.1348 (1.8); 4.0973 (1.6); 3.9439 (0.6); 3.9336 (0.7); 3.9233 (1.1); 3.9130 (0.7); 3.9028 (0.6); 3.4661 (0.8); 3.4481 (1.2); 3.4326 (1.2); 3.4301 (1.0); 3.4147 (1.1); 3.4120 (1.1); 3.3970 (1.2); 3.3796 (0.7); 2.7421 (2.0); 2.7246 (4.0); 2.7070 (1.8); 2.4998 (1.2); 2.4884 (1.3); 2.4713 (0.9); 2.4637 (1.5); 2.4521 (2.2); 2.4288 (0.8); 2.4238 (0.9); 2.4093 (1.0); 2.3996 (1.1); 2.3854 (1.1); 2.3426 (0.5); 2.3240 (16.0); 2.2123 (0.7); 2.1991 (0.5); 2.1882 (0.6); 2.1798 (0.8); 2.1555 (0.6); 2.0796 (1.5); 2.0583 (1.4); 2.0435 (1.3); 2.0222 (1.2); 1.7360 (0.6); 1.7264 (0.6); 1.7132 (0.6); -0.0002 (9.8) I.1-252: 1 H-NMR (400.1 MHz, CDCl3): δ= 7.5196 (1.8); 7.3109 (0.6); 7.3086 (0.5); 7.2977 (0.3); 7.2609 (311.4); 7.1347 (4.1); 7.1305 (1.7); 7.1139 (12.8); 7.1002 (4.9); 7.0936 (11.6); 7.0888 (11.5); 7.0682 (9.4); 7.0044 (4.8); 6.9971 (6.7); 6.9888 (4.4); 6.9829 (3.6); 6.9780 (3.6); 6.9726 (3.2); 5.6899 (0.8); 5.5264 (0.3); 5.4750 (3.9); 5.2984 (0.9); 4.6505 (9.3); 4.6123 (11.0); 4.2807 (1.6); 4.2426 (1.4); 4.1944 (10.8); 4.1564 (9.2); 4.1306 (0.4); 4.1182 (0.6); 4.1105 (0.7); 4.0992 (1.0); 4.0912 (0.5); 4.0872 (0.6); 4.0789 (0.7); 4.0664 (2.1); 4.0543 (2.9); 4.0470 (4.1); 4.0416 (2.8); 4.0352 (5.5); 4.0274 (2.8); 4.0222 (4.3); 4.0158 (3.1); 4.0028 (2.0); 3.2425 (0.5); 2.7307 (0.9); 2.7182 (1.0); 2.7021 (1.1); 2.6921 (3.2); 2.6843 (4.9); 2.6754 (6.7); 2.6666 (6.3); 2.6573 (4.7); 2.6488 (2.7); 2.6396 (1.1); 2.5670 (0.4); 2.5610 (0.4); 2.5479 (1.8); 2.5357 (0.4); 2.5243 (2.8); 2.5049 (6.2); 2.4836 (7.2); 2.4624 (6.6); 2.4490 (5.2); 2.4432 (2.6); 2.4346 (12.4); 2.4248 (7.9); 2.4209 (8.7); 2.4110 (7.3); 2.4061 (3.2); 2.3975 (9.7); 2.3923 (3.3); 2.3837 (11.2); 2.3682 (3.5); 2.3515 (0.6); 2.3402 (0.6); 2.3321 (0.7); 2.3210 (0.4); 2.3103 (3.0); 2.2910 (4.7); 2.2868 (2.4); 2.2779 (3.1); 2.2715 (2.6); 2.2671 (3.6); 2.2585 (5.1); 2.2539 (2.9); 2.2477 (1.9); 2.2388 (2.8); 2.2345 (3.9); 2.2150 (1.8); 2.1191 (8.9); 2.0999 (8.8); 2.0823 (7.3); 2.0631 (7.1); 2.0333 (0.4); 2.0046 (0.5); 1.9698 (0.7); 1.8775 (3.4); 1.8753 (3.4); 1.8124 (1.5); 1.7996 (1.6); 1.7929 (3.2); 1.7811 (4.0); 1.7690 (4.9); 1.7596 (4.4); 1.7460 (4.4); 1.7366 (3.7); 1.7257 (2.7); 1.7119 (2.0); 1.6951 (0.4); 0.8312 (0.3); 0.8257 (0.4); 0.8142 (0.6); 0.8049 (4.7); 0.7875 (16.0); 0.7738 (14.1); 0.7698 (12.7); 0.7664 (7.1); 0.7569 (5.4); 0.7361 (0.8); 0.7286 (0.5); 0.7162 (0.6); 0.5645 (0.4); 0.5540 (0.5); 0.5379 (0.6); 0.5274 (1.0); 0.5150 (1.2); 0.5045 (0.7); 0.4729 (5.4); 0.4629 (11.4); 0.4596 (12.5); 0.4564 (12.9); 0.4538 (12.2); 0.4500 (12.7); 0.4470 (12.0); 0.4332 (4.6); 0.4162 (0.4); 0.1464 (0.5); 0.0081 (3.5); 0.0000 (117.6) I.1-254: 1 H-NMR (400.1 MHz, d6-DMSO): δ= 8.3599 (0.7); 8.3510 (1.1); 8.3400 (0.8); 8.3308 (1.0); 7.3878 (0.5); 7.3840 (0.5); 7.3672 (1.0); 7.3634 (1.1); 7.3575 (0.6); 7.3475 (0.7); 7.3415 (1.1); 7.3376 (1.0); 7.3211 (0.6); 7.3175 (0.6); 7.2526 (1.0); 7.2343 (2.3); 7.2285 (1.4); 7.2226 (1.4); 7.2170 (1.2); 7.2117 (1.6); 7.2056 (2.4); 7.2000 (1.8); 7.1931 (2.8); 7.1880 (2.4); 7.1833 (1.8); 7.1749 (2.7); 7.1713 (2.5); 7.1583 (1.7); 7.1537 (2.6); 7.1360 (1.3); 7.1226 (0.5); 7.1182 (0.4); 7.0947 (1.1); 7.0786 (1.5); 7.0595 (0.8); 5.2670 (0.8); 5.2492 (1.4); 5.2304 (1.2); 5.2116 (0.4); 4.7613 (1.8); 4.7216 (2.0); 4.2776 (1.4); 4.2673 (0.9); 4.2377 (1.2); 4.2275 (0.8); 3.8763 (0.5); 3.8657 (0.8); 3.8552 (1.1); 3.8451 (1.2); 3.8351 (0.9); 3.8246 (0.6); 3.4148 (16.0); 3.1685 (0.7); 2.9503 (0.3); 2.9406 (0.4); 2.9292 (0.4); 2.9193 (0.5); 2.9115 (0.7); 2.9017 (0.8); 2.8896 (0.7); 2.8799 (0.7); 2.8251 (0.6); 2.8045 (1.3); 2.7841 (1.0); 2.7746 (0.8); 2.7649 (0.7); 2.7449 (0.4); 2.6693 (0.4); 2.5985 (0.9); 2.5873 (1.0); 2.5823 (0.7); 2.5708 (0.7); 2.5639 (1.2); 2.5526 (1.3); 2.5480 (1.0); 2.5397 (0.7); 2.5363 (0.8); 2.5228 (0.8); 2.5180 (1.3); 2.5094 (22.6); 2.5049 (50.1); 2.5003 (70.6); 2.4957 (51.3); 2.4911 (24.5); 2.4246 (0.4); 2.4011 (0.9); 2.3913 (0.6); 2.3818 (1.8); 2.3702 (1.2); 2.3603 (1.8); 2.3502 (1.2); 2.3402 (1.6); 2.3310 (0.7); 2.3274 (0.8); 2.3180 (0.7); 2.3055 (0.8); 2.2929 (1.2); 2.2816 (1.3); 2.2765 (1.2); 2.2694 (2.0); 2.2548 (1.0); 2.2483 (1.4); 2.2406 (1.2); 2.2352 (1.2); 2.2274 (0.7); 2.2204 (0.9); 2.2136 (1.1); 2.2014 (0.4); 2.1911 (0.5); 2.1777 (0.4); 2.1716 (0.8); 2.1601 (0.6); 2.1483 (0.7); 2.1411 (0.7); 2.1366 (0.5); 2.1291 (0.3); 2.1217 (0.4); 2.1171 (0.5); 1.8401 (0.4); 1.8346 (0.4); 1.8282 (0.5); 1.8239 (0.5); 1.8169 (0.8); 1.8045 (0.8); 1.7970 (0.6); 1.7930 (0.7); 1.7857 (0.6); 1.7749 (0.4); 1.7659 (0.6); 1.7445 (1.2); 1.7343 (0.6); 1.7243 (1.1); 1.7131 (1.1); 1.7043 (0.5); 1.6928 (1.0); 1.6728 (0.3); 0.0082 (0.6) I.1-255: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.9634 (3.8); 8.9592 (4.2); 8.9523 (4.1); 8.9481 (4.0); 8.6792 (1.2); 8.6644 (2.4); 8.6498 (1.2); 8.5056 (2.4); 8.4860 (2.5); 8.0392 (4.6); 8.0175 (5.3); 7.8521 (4.7); 7.8490 (4.9); 7.7265 (3.7); 7.7217 (3.4); 7.7047 (3.2); 7.6998 (3.0); 7.6571 (3.4); 7.6460 (3.4); 7.6363 (3.3); 7.6253 (3.3); 7.3786 (0.7); 7.3747 (0.8); 7.3581 (1.6); 7.3542 (1.7); 7.3480 (0.9); 7.3384 (1.2); 7.3324 (1.7); 7.3280 (1.4); 7.3119 (0.9); 7.3079 (0.9); 7.2057 (0.9); 7.2018 (1.0); 7.1929 (1.0); 7.1891 (1.2); 7.1857 (1.8); 7.1821 (1.9); 7.1730 (1.7); 7.1696 (2.0); 7.1655 (1.2); 7.1615 (1.2); 7.1526 (1.0); 7.1491 (1.0); 7.0861 (1.9); 7.0701 (2.5); 7.0668 (2.4); 7.0507 (1.3); 4.7617 (2.8); 4.7221 (3.2); 4.5217 (0.8); 4.5074 (0.8); 4.4832 (2.8); 4.4686 (2.9); 4.4590 (2.8); 4.4447 (2.9); 4.4201 (0.9); 4.4059 (0.9); 4.2547 (3.8); 4.2150 (3.4); 4.0404 (0.8); 3.8749 (1.0); 3.8643 (1.6); 3.8539 (2.1); 3.8437 (2.4); 3.8337 (2.0); 3.8234 (1.5); 3.8128 (0.9); 3.1679 (16.0); 3.1127 (0.8); 3.1007 (0.7); 3.0945 (0.8); 3.0825 (0.7); 2.7669 (1.3); 2.7553 (1.0); 2.6714 (0.6); 2.6668 (0.5); 2.6546 (2.2); 2.6435 (2.3); 2.6194 (2.8); 2.6083 (2.6); 2.5249 (1.0); 2.5202 (1.7); 2.5115 (31.3); 2.5069 (69.6); 2.5023 (97.9); 2.4977 (69.2); 2.4931 (31.2); 2.4155 (0.7); 2.3963 (1.0); 2.3919 (1.0); 2.3733 (1.9); 2.3547 (4.6); 2.3332 (4.3); 2.3245 (1.0); 2.3196 (2.7); 2.2979 (3.7); 2.2841 (1.9); 2.2733 (2.4); 2.2601 (2.3); 2.2558 (1.1); 2.2426 (0.9); 2.2314 (1.3); 2.2187 (1.3); 2.1855 (0.9); 2.1663 (1.4); 2.1617 (0.8); 2.1543 (1.1); 2.1472 (0.9); 2.1423 (1.2); 2.1351 (1.7); 2.1304 (1.0); 2.1232 (0.6); 2.1155 (1.0); 2.1108 (1.2); 2.0915 (0.6); 2.0746 (0.5); 1.8426 (0.8); 1.8305 (1.2); 1.8194 (1.6); 1.8091 (1.3); 1.7988 (1.3); 1.7879 (1.4); 1.7771 (0.9); 1.7642 (0.6); 1.1974 (1.6); 1.1792 (3.6); 1.1609 (1.6); 1.0511 (1.1); 1.0332 (0.5); 0.0080 (1.5); 0.0048 (0.5); 0.0040 (0.7); 0.0023 (2.0); -0.0002 (51.2); -0.0058 (0.6); - 0.0067 (0.5); -0.0085 (1.4) I.1-257: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.2693 (1.6); 8.2496 (1.7); 7.7032 (0.5); 7.1433 (1.9); 7.1230 (8.1); 7.1112 (8.9); 7.0901 (1.8); 4.6608 (1.9); 4.6227 (2.1); 4.2432 (0.6); 4.2291 (0.9); 4.2196 (0.9); 4.2081 (1.0); 4.1854 (0.7); 4.0554 (2.2); 4.0176 (2.0); 3.7197 (0.7); 3.7093 (0.9); 3.6991 (1.1); 3.6890 (0.9); 3.6789 (0.7); 3.3480 (7.8); 3.1638 (0.5); 2.6744 (0.6); 2.6698 (0.9); 2.6652 (0.7); 2.5383 (0.8); 2.5336 (1.4); 2.5277 (2.5); 2.5234 (3.1); 2.5185 (4.0); 2.5099 (51.7); 2.5053 (112.9); 2.5007 (157.3); 2.4961 (109.6); 2.4915 (48.8); 2.4823 (1.8); 2.4607 (0.6); 2.4565 (0.7); 2.3472 (1.1); 2.3276 (1.8); 2.3051 (1.0); 2.2759 (16.0); 2.2542 (1.0); 2.2440 (1.1); 2.2302 (1.2); 2.2151 (1.7); 2.2019 (0.7); 2.1933 (1.7); 2.1811 (1.4); 2.1591 (1.2); 2.0320 (0.6); 2.0194 (0.6); 2.0081 (0.7); 2.0009 (0.9); 1.9759 (0.6); 1.7176 (0.6); 1.7057 (0.8); 1.6956 (0.7); 1.6840 (0.7); 1.6736 (0.7); 1.6001 (0.7); 1.5867 (0.8); 1.5106 (1.4); 1.4990 (1.9); 1.4854 (2.0); 1.4740 (1.3); 1.4632 (1.1); 0.8911 (9.8); 0.8748 (9.4); 0.8248 (9.9); 0.8086 (9.7); 0.0080 (1.7); 0.0048 (0.7); -0.0002 (54.7); -0.0085 (1.4) I.1-260: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.6537 (0.6); 8.6390 (1.2); 8.6231 (0.6); 7.1471 (1.9); 7.1268 (7.1); 7.1127 (7.8); 7.0919 (1.9); 4.6712 (1.9); 4.6334 (2.1); 4.0155 (2.2); 3.9776 (1.9); 3.9324 (0.6); 3.9164 (0.7); 3.9077 (1.9); 3.8917 (1.8); 3.8830 (2.0); 3.8670 (1.9); 3.8583 (0.7); 3.8421 (0.6); 3.7341 (0.7); 3.7233 (0.9); 3.7124 (1.0); 3.7025 (0.9); 3.6916 (0.7); 3.3165 (134.4); 2.6698 (0.6); 2.6187 (1.4); 2.6077 (1.4); 2.5835 (1.6); 2.5727 (1.6); 2.5232 (1.5); 2.5185 (2.2); 2.5098 (35.4); 2.5052 (77.1); 2.5006 (107.8); 2.4960 (75.4); 2.4914 (33.8); 2.3548 (1.1); 2.3321 (1.3); 2.3277 (0.9); 2.3229 (0.6); 2.3128 (0.8); 2.2765 (16.0); 2.2627 (1.2); 2.2521 (1.4); 2.2460 (1.9); 2.2385 (1.3); 2.2232 (1.8); 2.2106 (2.0); 2.1966 (0.7); 2.1880 (1.4); 2.0577 (0.7); 2.0452 (0.6); 2.0337 (0.7); 2.0259 (0.9); 2.0212 (0.6); 2.0069 (0.5); 2.0019 (0.7); 1.6941 (0.6); 1.6833 (0.8); 1.6731 (0.7); 1.6616 (0.6); 1.6512 (0.7) I.1-261: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 9.2012 (2.2); 9.1931 (2.2); 8.3078 (0.5); 6.9931 (1.3); 6.9901 (1.4); 6.9720 (1.6); 6.9690 (1.4); 6.6578 (1.5); 6.6497 (1.5); 6.6446 (0.5); 6.6415 (0.5); 6.6365 (1.4); 6.6284 (1.4); 3.3219 (22.1); 3.2981 (0.5); 2.8333 (0.6); 2.8182 (0.5); 2.5193 (0.5); 2.5108 (5.1); 2.5062 (10.9); 2.5016 (15.3); 2.4970 (10.7); 2.4924 (4.9); 2.2171 (0.8); 2.1965 (0.7); 2.1831 (0.6); 2.0857 (2.9); 1.3266 (16.0); 1.3198 (15.8) I.1-262: 1 H-NMR (400.0 MHz, CDCl3): δ= 7.3405 (0.8); 7.3196 (1.0); 7.2610 (7.5); 7.1102 (0.9); 7.0893 (0.8); 7.0301 (0.6); 2.7640 (0.8); 1.3063 (16.0); -0.0002 (2.0) I.1-264: 1 H-NMR (400.1 MHz, CDCl3): δ= 7.5180 (3.6); 7.3597 (0.5); 7.3096 (1.7); 7.3000 (0.5); 7.2886 (0.7); 7.2764 (1.1); 7.2593 (651.7); 7.1600 (0.9); 7.1551 (1.3); 7.1337 (9.7); 7.1290 (9.5); 7.1071 (1.1); 6.9954 (3.7); 5.2199 (0.9); 4.7489 (2.0); 4.7116 (2.4); 4.1742 (2.3); 4.1362 (2.0); 3.9797 (0.4); 3.9674 (0.8); 3.9567 (1.0); 3.9463 (1.2); 3.9367 (1.0); 3.9258 (0.8); 3.9148 (0.4); 3.6476 (0.4); 3.2344 (1.9); 2.5848 (1.7); 2.5737 (1.7); 2.5597 (0.5); 2.5480 (2.1); 2.5367 (2.4); 2.5158 (1.1); 2.4937 (0.9); 2.4732 (0.8); 2.4482 (1.0); 2.4336 (1.1); 2.4239 (1.3); 2.4098 (1.4); 2.3913 (0.4); 2.3810 (0.7); 2.3673 (0.8); 2.3356 (1.1); 2.3273 (16.0); 2.3043 (0.7); 2.2851 (1.0); 2.2806 (0.6); 2.2720 (0.6); 2.2662 (0.6); 2.2611 (0.7); 2.2528 (1.0); 2.2481 (0.6); 2.2424 (0.4); 2.2333 (0.6); 2.2285 (0.9); 2.2092 (0.4); 2.1851 (2.0); 2.1633 (2.0); 2.1482 (1.6); 2.1264 (1.7); 2.0039 (0.3); 1.8399 (0.5); 1.8265 (0.6); 1.8154 (0.8); 1.8052 (0.7); 1.8024 (0.7); 1.7931 (0.7); 1.7825 (0.7); 1.7719 (0.5); 1.7586 (0.4); 1.5393 (82.4); 1.4789 (0.4); 1.4609 (0.3); 1.4511 (0.3); 1.4276 (0.3); 1.4147 (0.4); 1.3335 (0.3); 1.2943 (0.4); 1.2849 (0.4); 1.2563 (1.2); 0.8344 (0.4); 0.8281 (0.4); 0.1462 (1.0); 0.0503 (0.5); 0.0081 (7.3); 0.0056 (2.4) I.1-265: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.4139 (0.6); 8.3944 (0.7); 8.3892 (0.7); 8.3698 (0.6); 7.2063 (2.3); 7.1858 (4.4); 7.1433 (2.4); 7.1366 (2.5); 7.1226 (1.4); 7.1161 (1.3); 4.6958 (0.8); 4.6888 (0.8); 4.6576 (0.8); 4.6505 (0.8); 4.0206 (0.8); 4.0082 (0.8); 3.9825 (0.7); 3.9702 (0.7); 3.6079 (10.5); 3.6001 (10.4); 3.4905 (1.5); 2.8776 (0.8); 2.8602 (1.2); 2.8430 (0.9); 2.5648 (0.9); 2.5539 (0.9); 2.5312 (0.7); 2.5190 (1.2); 2.5101 (10.5); 2.5055 (22.5); 2.5009 (31.0); 2.4964 (21.7); 2.4918 (9.7); 2.3278 (0.6); 2.2528 (0.6); 2.2455 (0.7); 2.2389 (0.6); 2.2242 (0.7); 2.2106 (1.0); 2.1896 (0.6); 2.1862 (0.6); 2.0730 (0.9); 2.0203 (0.5); 1.5694 (0.5); 1.5361 (0.8); 1.5237 (0.5); 1.5112 (0.8); 1.4972 (1.1); 1.4838 (0.9); 1.4740 (0.6); 1.4616 (0.8); 1.1946 (16.0); 1.1773 (15.7); 0.8925 (4.5); 0.8780 (4.3); 0.8763 (4.3); 0.8308 (3.8); 0.8273 (4.0); 0.8146 (3.8); 0.8111 (3.7); - 0.0002 (10.9) I.1-266: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 7.6309 (6.1); 7.6256 (6.0); 7.4198 (2.8); 7.4144 (2.5); 7.3990 (3.4); 7.3936 (3.2); 7.2576 (4.1); 7.2367 (3.2); 4.6502 (2.0); 4.6093 (2.2); 4.2466 (2.5); 4.2057 (2.1); 3.9215 (0.8); 3.9106 (1.1); 3.9011 (1.3); 3.8909 (1.1); 3.8811 (0.9); 3.6266 (0.6); 3.6079 (1.2); 3.5902 (2.0); 3.5752 (2.1); 3.5575 (1.1); 3.5386 (0.6); 3.5206 (0.5); 3.3973 (85.9); 3.3434 (2.0); 3.2955 (1.1); 3.2378 (1.1); 3.2247 (1.1); 3.1676 (3.9); 3.1536 (2.2); 3.1397 (2.4); 3.1357 (2.4); 3.1218 (2.2); 3.1098 (1.3); 3.0466 (1.2); 3.0334 (1.8); 3.0214 (1.7); 3.0087 (1.8); 2.9945 (1.4); 2.9813 (0.9); 2.9495 (1.1); 2.9396 (1.1); 2.7673 (16.0); 2.7553 (14.9); 2.7390 (0.9); 2.7318 (0.7); 2.7162 (0.8); 2.6968 (0.7); 2.6897 (1.2); 2.6789 (0.9); 2.6745 (1.8); 2.6699 (2.0); 2.6652 (1.3); 2.5885 (0.6); 2.5490 (1.9); 2.5445 (2.7); 2.5400 (3.2); 2.5232 (6.3); 2.5186 (8.6); 2.5100 (101.4); 2.5053 (213.2); 2.5007 (293.0); 2.4961 (204.9); 2.4915 (90.3); 2.4497 (1.2); 2.4453 (2.5); 2.4407 (1.7); 2.4276 (1.2); 2.4095 (0.5); 2.4051 (1.2); 2.4003 (1.7); 2.3957 (1.6); 2.3915 (1.1); 2.3322 (1.8); 2.3275 (2.2); 2.3230 (2.1); 2.3183 (0.9); 2.3108 (1.4); 2.2995 (1.4); 2.2718 (1.9); 2.2628 (1.5); 2.2548 (0.8); 2.2485 (0.6); 2.2361 (1.0); 2.2120 (0.6); 2.0721 (1.7); 1.8409 (0.6); 1.8230 (1.4); 1.8037 (1.8); 1.7861 (1.9); 1.7666 (1.3); 1.7465 (0.6); 1.7347 (0.6); 1.0565 (7.1); 1.0385 (16.0); 1.0205 (6.8); 0.0489 (0.6); 0.0080 (2.7); -0.0002 (92.8); -0.0085 (2.5); -0.0505 (0.6) I.1-267: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.3372 (0.6); 8.3233 (1.2); 8.3097 (0.6); 7.2057 (1.3); 7.2010 (1.5); 7.1902 (4.8); 7.1871 (5.4); 7.1837 (4.2); 7.1775 (3.2); 7.1744 (3.1); 7.1624 (2.5); 7.1573 (1.9); 7.1476 (1.2); 7.1413 (2.3); 7.1393 (2.2); 7.1372 (1.8); 7.1191 (6.2); 7.1019 (6.9); 7.0966 (1.5); 7.0813 (2.0); 4.6721 (1.7); 4.6342 (1.8); 4.2618 (4.2); 4.2479 (4.2); 4.0068 (1.9); 3.9689 (1.7); 3.7397 (0.6); 3.7288 (0.8); 3.7175 (0.9); 3.7083 (0.8); 3.6974 (0.7); 3.4652 (7.2); 3.1679 (0.8); 3.1523 (1.0); 2.6258 (1.4); 2.6069 (4.5); 2.5880 (5.1); 2.5743 (1.4); 2.5693 (1.7); 2.5505 (1.5); 2.5398 (1.5); 2.5232 (0.6); 2.5185 (0.8); 2.5098 (13.5); 2.5052 (29.7); 2.5006 (41.5); 2.4960 (29.2); 2.4914 (13.1); 2.3461 (1.0); 2.3273 (1.2); 2.3232 (1.0); 2.3040 (0.8); 2.2739 (13.9); 2.2577 (1.2); 2.2472 (1.2); 2.2336 (1.3); 2.2127 (1.6); 2.2054 (0.7); 2.1901 (1.7); 2.1779 (1.3); 2.1552 (1.2); 2.0624 (0.7); 2.0499 (0.5); 2.0383 (0.6); 2.0309 (0.8); 2.0260 (0.6); 2.0066 (0.6); 1.7386 (0.5); 1.7279 (0.8); 1.7175 (0.6); 1.7064 (0.6); 1.6959 (0.7); 1.1565 (6.9); 1.1377 (16.0); 1.1188 (6.8); - 0.0002 (8.2) I.1-268: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 9.2274 (0.5); 8.9569 (1.1); 7.3921 (0.6); 7.3724 (1.2); 7.3495 (1.2); 7.3252 (0.7); 7.2149 (0.6); 7.1946 (1.3); 7.1825 (1.4); 7.1645 (0.7); 7.0621 (1.1); 7.0468 (1.6); 7.0274 (0.8); 4.6753 (1.0); 4.6347 (1.2); 4.2501 (2.1); 4.2095 (1.9); 3.8530 (1.2); 3.5683 (4.2); 3.2012 (0.8); 3.1826 (2.3); 3.1666 (3.8); 3.1511 (2.4); 3.0606 (2.8); 2.9520 (9.6); 2.7495 (16.0); 2.7376 (14.6); 2.6877 (1.5); 2.6794 (1.7); 2.6700 (1.6); 2.6654 (1.1); 2.5235 (3.9); 2.5188 (5.7); 2.5101 (84.2); 2.5056 (183.0); 2.5010 (256.0); 2.4963 (179.1); 2.4918 (79.4); 2.4501 (0.8); 2.4270 (0.8); 2.4065 (1.5); 2.3836 (2.0); 2.3654 (1.8); 2.3424 (1.5); 2.3279 (1.6); 2.3003 (0.9); 2.2874 (1.1); 2.2760 (1.4); 2.2631 (1.4); 2.2338 (0.9); 2.2225 (0.9); 2.1583 (1.0); 2.0733 (0.7); 1.8751 (1.6); 1.8569 (2.0); 1.8374 (1.7); 1.8215 (1.2); 1.8104 (1.1); 1.7909 (1.0); 1.7796 (0.8); 1.0969 (5.9); 1.0787 (12.4); 1.0605 (5.5); 0.0081 (1.7); -0.0002 (57.4); -0.0086 (1.5) I.1-269: 1 H-NMR (400.1 MHz, d 6 -DMSO): δ= 11.5018 (1.1); 7.4091 (1.5); 7.4045 (0.5); 7.3930 (0.6); 7.3882 (2.2); 7.2648 (1.7); 7.2438 (1.3); 4.6430 (0.6); 4.6040 (0.7); 4.1229 (0.7); 4.0840 (0.6); 3.7497 (0.3); 3.3748 (11.4); 3.1681 (1.3); 2.7710 (16.0); 2.7166 (0.4); 2.7062 (0.4); 2.6791 (0.5); 2.6687 (0.5); 2.5110 (4.2); 2.5066 (9.2); 2.5021 (13.0); 2.4976 (9.5); 2.4931 (4.5); 2.3897 (0.3); 2.3552 (0.5); 2.3330 (0.5); 2.3177 (0.4); 2.2953 (0.4); 2.2917 (0.4); 2.2806 (0.4); 2.2670 (0.3) I.1-270: 1 H-NMR (400.1 MHz, CDCl3): δ= 7.5235 (0.5); 7.5202 (0.6); 7.3105 (0.4); 7.2647 (84.8); 7.2614 (108.9); 7.1263 (0.9); 7.1132 (1.9); 7.1012 (3.7); 7.0931 (2.9); 7.0767 (5.6); 7.0705 (4.3); 7.0592 (16.0); 7.0489 (13.5); 7.0393 (4.9); 7.0199 (0.4); 7.0008 (0.4); 6.9974 (0.6); 5.7716 (0.7); 5.5327 (3.5); 5.3018 (1.7); 5.2985 (2.2); 4.8712 (1.1); 4.8405 (6.8); 4.8017 (7.5); 4.3545 (1.4); 4.3160 (1.2); 4.2790 (8.2); 4.2402 (7.1); 4.0405 (0.3); 4.0285 (0.5); 4.0196 (0.6); 4.0102 (0.5); 3.9891 (1.3); 3.9777 (2.3); 3.9687 (3.2); 3.9579 (4.3); 3.9472 (3.3); 3.9367 (2.4); 3.9262 (1.1); 3.2418 (0.4); 2.8976 (0.7); 2.8883 (0.7); 2.8575 (0.9); 2.8482 (0.9); 2.7045 (0.7); 2.6967 (1.7); 2.6870 (3.0); 2.6788 (4.0); 2.6695 (4.1); 2.6606 (3.0); 2.6519 (1.8); 2.6429 (0.7); 2.5719 (4.5); 2.5606 (4.5); 2.5494 (1.6); 2.5351 (6.1); 2.5250 (6.5); 2.5064 (5.2); 2.4855 (4.6); 2.4642 (4.9); 2.4425 (3.7); 2.4283 (3.5); 2.4186 (4.0); 2.4040 (5.1); 2.3880 (1.5); 2.3755 (2.4); 2.3617 (2.4); 2.3254 (1.8); 2.3064 (3.0); 2.2926 (2.3); 2.2867 (2.3); 2.2830 (2.2); 2.2739 (3.4); 2.2687 (2.0); 2.2535 (2.5); 2.2309 (1.3); 2.1439 (6.2); 2.1221 (6.5); 2.1076 (6.1); 2.0859 (5.9); 1.8772 (1.5); 1.8662 (2.6); 1.8537 (2.7); 1.8431 (3.0); 1.8325 (3.2); 1.8213 (2.7); 1.8098 (2.5); 1.7957 (1.4); 1.7767 (0.4); 0.8358 (0.3); 0.8164 (1.1); 0.7959 (3.3); 0.7818 (11.2); 0.7786 (10.4); 0.7671 (9.8); 0.7644 (11.0); 0.7609 (8.0); 0.7496 (3.0); 0.7236 (0.3); 0.5735 (0.3); 0.5480 (2.1); 0.5215 (0.5); 0.5116 (0.5); 0.4807 (2.9); 0.4665 (10.5); 0.4620 (9.6); 0.4574 (9.6); 0.4428 (2.5); 0.0117 (0.9); 0.0034 (31.3); 0.0000 (41.4) I.1-271: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.3435 (2.0); 8.3224 (2.0); 7.2816 (0.8); 7.2632 (2.1); 7.2436 (3.1); 7.2403 (2.8); 7.2362 (2.8); 7.2216 (8.3); 7.2155 (8.5); 7.1993 (4.2); 7.1865 (1.6); 7.1818 (1.9); 7.1656 (0.8); 7.1268 (4.0); 7.1071 (7.9); 7.0806 (3.2); 7.0564 (6.0); 7.0363 (3.2); 4.5971 (2.0); 4.5591 (2.4); 4.4465 (0.9); 4.4347 (0.9); 4.4207 (1.0); 4.4143 (1.0); 4.4008 (0.7); 4.3886 (0.6); 3.9902 (1.0); 3.9532 (0.9); 3.8746 (1.9); 3.8365 (1.8); 3.5636 (1.1); 3.5520 (1.1); 3.5320 (0.6); 3.3360 (242.8); 3.1673 (0.7); 3.0881 (1.2); 3.0764 (1.2); 3.0535 (1.6); 3.0416 (1.4); 2.8338 (1.4); 2.8078 (1.4); 2.7993 (1.4); 2.7738 (1.0); 2.6746 (1.1); 2.6700 (1.6); 2.6655 (1.1); 2.5403 (1.5); 2.5234 (4.1); 2.5187 (6.4); 2.5101 (94.9); 2.5055 (203.7); 2.5009 (281.8); 2.4964 (196.3); 2.4918 (88.0); 2.4786 (2.8); 2.4680 (1.8); 2.4556 (1.1); 2.4444 (1.6); 2.4344 (1.3); 2.3323 (1.2); 2.3278 (1.5); 2.3232 (1.1); 2.2707 (16.0); 2.2521 (1.4); 2.2312 (1.6); 2.2100 (1.1); 2.1844 (1.1); 2.1715 (1.3); 2.1606 (1.4); 2.1473 (1.4); 2.1240 (1.4); 2.1011 (1.6); 2.0903 (1.5); 2.0672 (1.3); 2.0588 (0.8); 2.0365 (0.6); 1.8766 (0.7); 1.8522 (0.7); 1.8441 (0.8); 1.8198 (0.7); 1.6454 (0.6); 1.6341 (0.8); 1.6124 (0.8); 1.6027 (0.7); -0.0002 (6.5) I.1-272: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.3528 (2.1); 8.3320 (2.2); 7.2819 (1.4); 7.2636 (3.2); 7.2612 (3.2); 7.2511 (1.5); 7.2441 (4.1); 7.2411 (3.4); 7.2368 (2.6); 7.2213 (7.7); 7.2166 (8.9); 7.1999 (5.0); 7.1866 (2.5); 7.1824 (2.1); 7.1695 (1.1); 7.1661 (1.0); 7.1271 (4.1); 7.1072 (8.2); 7.0803 (5.0); 7.0561 (4.8); 7.0357 (2.5); 4.5973 (2.2); 4.5593 (2.5); 4.4706 (0.6); 4.4572 (0.8); 4.4450 (1.0); 4.4330 (0.8); 4.4241 (1.0); 4.4120 (0.7); 4.3986 (0.6); 3.9909 (1.7); 3.9528 (1.6); 3.8720 (1.7); 3.8340 (1.7); 3.6006 (1.5); 3.5897 (1.7); 3.5799 (2.0); 3.5700 (2.1); 3.5596 (2.1); 3.5498 (2.0); 3.5411 (1.9); 3.5300 (1.7); 3.3683 (99.8); 3.1676 (0.9); 3.0881 (1.5); 3.0770 (1.6); 3.0535 (1.9); 3.0428 (1.8); 2.8321 (1.9); 2.8265 (2.0); 2.7990 (2.4); 2.7921 (2.0); 2.7721 (1.8); 2.7665 (1.9); 2.6751 (2.0); 2.6707 (2.2); 2.6661 (2.1); 2.6047 (1.7); 2.5523 (2.1); 2.5408 (2.4); 2.5240 (4.5); 2.5193 (5.9); 2.5105 (48.9); 2.5061 (105.5); 2.5016 (148.6); 2.4971 (117.4); 2.4929 (62.4); 2.4790 (4.2); 2.4681 (2.3); 2.4543 (2.8); 2.4443 (2.9); 2.4341 (1.7); 2.3329 (1.0); 2.3284 (1.3); 2.3238 (1.1); 2.2921 (0.9); 2.2676 (16.0); 2.2507 (1.9); 2.2302 (1.9); 2.2088 (1.2); 2.1841 (1.3); 2.1706 (1.4); 2.1603 (1.6); 2.1463 (1.5); 2.1228 (1.3); 2.1002 (1.4); 2.0895 (1.6); 2.0738 (0.7); 2.0666 (1.5); 2.0573 (1.1); 2.0347 (0.9); 1.8716 (0.5); 1.8511 (0.6); 1.8424 (0.7); 1.8191 (0.6); 1.7616 (0.5); 1.7376 (0.6); 1.7295 (0.6); 1.7054 (0.6); 1.6330 (0.6); 1.6228 (0.6); 1.6110 (0.6); 1.3789 (0.6); 1.3669 (0.6); 1.3562 (0.6); 1.3466 (0.5); -0.0002 (10.1) I.1-273: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.1483 (1.9); 7.1279 (7.7); 7.1155 (8.4); 7.1097 (1.4); 7.0947 (1.8); 4.6871 (1.1); 4.6812 (1.1); 4.6494 (1.3); 4.6431 (1.3); 4.6360 (1.1); 4.6211 (2.0); 4.6055 (2.0); 4.5908 (1.0); 4.0424 (2.2); 4.0043 (2.0); 3.7107 (0.6); 3.7002 (1.0); 3.6898 (1.0); 3.6793 (1.0); 3.6687 (0.7); 3.4052 (2.2); 3.3714 (124.8); 3.3330 (1.0); 2.7638 (0.8); 2.7541 (0.9); 2.7429 (0.8); 2.7334 (0.8); 2.7247 (1.1); 2.7151 (1.0); 2.7042 (1.0); 2.6947 (1.0); 2.6714 (0.5); 2.5412 (0.8); 2.5364 (1.2); 2.5320 (1.3); 2.5248 (1.8); 2.5200 (2.5); 2.5114 (32.7); 2.5069 (68.3); 2.5023 (91.6); 2.4977 (63.3); 2.4931 (28.1); 2.4211 (1.3); 2.4160 (0.7); 2.4080 (1.4); 2.3988 (1.7); 2.3923 (0.8); 2.3854 (1.3); 2.3823 (1.4); 2.3740 (1.0); 2.3689 (1.4); 2.3601 (1.1); 2.3467 (1.0); 2.3291 (0.6); 2.2947 (0.6); 2.2914 (0.7); 2.2745 (16.0); 2.2532 (1.0); 2.2143 (0.5); 2.1448 (0.7); 2.1324 (0.6); 2.1266 (0.5); 2.1198 (0.6); 2.1143 (0.8); 2.1078 (0.6); 2.0947 (0.5); 2.0882 (0.6); 1.7223 (0.5); 1.7145 (0.8); 1.7051 (1.2); 1.6969 (1.2); 1.6911 (1.2); 1.6828 (1.4); 1.6730 (1.1); 1.6654 (0.8); 1.6624 (0.8); 1.6580 (0.6); 1.6499 (0.5); 1.0743 (8.5); 1.0722 (8.4); 1.0583 (8.5); 1.0563 (8.2); 0.8325 (12.6); 0.8288 (13.0); 0.8154 (12.2); 0.8118 (12.5); 0.0080 (0.9); -0.0002 (29.8); -0.0085 (0.8) I.1-274: 1 H-NMR (400.1 MHz, CDCl 3 ): δ= 7.5186 (0.3); 7.2713 (4.3); 7.2617 (44.5); 7.2599 (59.8); 7.1445 (0.3); 7.1231 (16.0); 5.9312 (0.6); 4.7441 (1.5); 4.7064 (1.7); 4.1310 (1.7); 4.0934 (1.5); 3.9549 (0.6); 3.9453 (0.7); 3.9345 (1.0); 3.9243 (0.7); 3.9138 (0.5); 3.7114 (1.2); 3.7003 (14.3); 3.4938 (0.5); 3.4793 (1.6); 3.4639 (2.2); 3.4485 (1.5); 3.4334 (0.5); 2.5368 (0.4); 2.5269 (1.3); 2.5152 (3.2); 2.5005 (3.6); 2.4920 (2.1); 2.4855 (2.2); 2.4794 (1.4); 2.4520 (0.6); 2.4262 (0.6); 2.4121 (0.7); 2.4017 (0.8); 2.3878 (0.8); 2.3593 (0.4); 2.3447 (0.5); 2.3270 (11.7); 2.2294 (0.6); 2.2160 (0.4); 2.2054 (0.5); 2.1971 (0.6); 2.1773 (0.4); 2.1727 (0.5); 2.1089 (1.1); 2.0874 (1.1); 2.0726 (0.9); 2.0513 (0.9); 1.7948 (0.5); 1.7828 (0.6); 1.7734 (0.6); 1.7596 (0.5); 1.7502 (0.5); 1.7390 (0.3); 1.5615 (2.1); 1.5526 (19.2); 1.5505 (24.4); 0.0102 (2.0); 0.0081 (2.1); 0.0019 (18.8); 0.0000 (25.6) I.1-275: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.6323 (15.5); 7.6269 (16.0); 7.4182 (7.1); 7.4128 (6.6); 7.3974 (8.9); 7.3920 (8.5); 7.2503 (10.9); 7.2294 (8.6); 7.1902 (4.7); 7.0585 (10.3); 6.9268 (5.3); 4.6082 (6.2); 4.5669 (7.6); 4.2451 (7.3); 4.2038 (6.1); 3.8757 (1.4); 3.8659 (2.2); 3.8559 (2.9); 3.8460 (3.2); 3.8343 (3.0); 3.8243 (2.5); 3.8145 (1.3); 3.1693 (1.0); 2.7965 (3.6); 2.7869 (3.8); 2.7570 (4.8); 2.7473 (4.5); 2.6704 (0.6); 2.5280 (4.8); 2.5241 (2.3); 2.5192 (2.3); 2.5105 (34.0); 2.5059 (76.5); 2.5013 (100.6); 2.4966 (70.6); 2.4920 (33.0); 2.4661 (4.1); 2.4595 (0.8); 2.4530 (1.5); 2.4506 (1.4); 2.4447 (1.3); 2.4374 (1.1); 2.4292 (3.5); 2.4110 (2.9); 2.4067 (2.6); 2.3981 (1.1); 2.3897 (1.4); 2.3760 (0.9); 2.3326 (0.8); 2.3273 (2.4); 2.3150 (2.2); 2.3028 (3.7); 2.2909 (3.6); 2.2615 (5.5); 2.2518 (3.7); 2.2409 (2.1); 2.2344 (1.6); 2.2224 (2.9); 2.2169 (1.4); 2.2102 (1.0); 2.2029 (1.6); 2.1980 (1.7); 2.1787 (0.8); 2.0854 (1.1); 2.0721 (1.2); 1.8182 (0.6); 1.7942 (2.4); 1.7829 (1.8); 1.7725 (2.9); 1.7647 (1.5); 1.7605 (1.5); 1.7555 (1.6); 1.7511 (1.6); 1.7405 (1.6); 1.7290 (1.0); -0.0002 (17.4); -0.0085 (0.6) I.1-276: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 12.7513 (0.8); 8.3582 (1.4); 8.3380 (1.7); 8.3201 (0.5); 7.2799 (1.5); 7.2617 (3.3); 7.2591 (2.6); 7.2494 (1.4); 7.2441 (4.1); 7.2321 (1.2); 7.2146 (6.6); 7.2063 (5.1); 7.1980 (7.6); 7.1944 (7.8); 7.1855 (2.9); 7.1678 (1.0); 7.1598 (1.3); 7.1537 (1.0); 7.1409 (2.0); 7.1343 (1.5); 7.1258 (1.0); 7.1194 (0.9); 7.0800 (2.7); 7.0610 (1.7); 4.7136 (2.0); 4.6747 (2.1); 4.4937 (0.5); 4.4813 (0.7); 4.4684 (0.9); 4.4606 (0.8); 4.4475 (0.7); 4.4355 (0.7); 4.0224 (1.7); 3.9826 (1.8); 3.9401 (0.6); 3.5620 (0.9); 3.3136 (215.0); 3.2630 (0.6); 3.1651 (0.6); 3.0917 (0.9); 3.0792 (1.2); 3.0564 (1.2); 3.0445 (1.3); 2.8333 (1.3); 2.8081 (1.4); 2.7992 (1.2); 2.7737 (1.1); 2.6788 (0.7); 2.6743 (1.6); 2.6697 (2.3); 2.6651 (1.6); 2.6605 (0.8); 2.5958 (1.0); 2.5829 (2.3); 2.5785 (2.4); 2.5639 (2.3); 2.5400 (1.1); 2.5232 (5.2); 2.5185 (8.0); 2.5098 (132.6); 2.5052 (291.5); 2.5006 (408.6); 2.4960 (288.1); 2.4914 (129.1); 2.4737 (2.5); 2.4499 (3.2); 2.4403 (2.2); 2.4002 (0.6); 2.3366 (1.2); 2.3321 (1.9); 2.3275 (2.7); 2.3228 (1.9); 2.2943 (1.0); 2.2715 (1.4); 2.2492 (0.8); 2.2006 (1.0); 2.1899 (1.1); 2.1760 (1.2); 2.1615 (2.1); 2.1478 (0.8); 2.1386 (1.5); 2.1266 (1.7); 2.1042 (1.0); 2.0730 (0.6); 1.8077 (0.6); 1.7850 (0.7); 1.7736 (0.7); 1.7530 (0.6); 1.4179 (0.7); 1.4088 (0.8); 1.1223 (7.0); 1.1035 (16.0); 1.0847 (6.8); 0.1462 (0.6); 0.0080 (5.8); 0.0063 (1.9); 0.0054 (2.3); - 0.0002 (189.8); -0.0060 (1.8); -0.0068 (1.5); -0.0085 (5.3); -0.0506 (0.8); -0.1496 (0.6) I.1-277: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 7.1453 (0.7); 7.1245 (3.7); 7.1170 (2.6); 7.1122 (2.3); 7.0962 (0.5); 4.6622 (0.8); 4.6239 (0.8); 4.0234 (0.8); 3.3765 (0.7); 3.3272 (115.7); 3.1665 (0.6); 2.6745 (0.6); 2.6699 (0.9); 2.6653 (0.6); 2.5549 (0.5); 2.5503 (0.7); 2.5454 (0.9); 2.5402 (0.8); 2.5342 (0.8); 2.5234 (2.5); 2.5187 (3.5); 2.5100 (47.9); 2.5054 (103.6); 2.5008 (145.0); 2.4962 (101.4); 2.4916 (45.3); 2.4715 (0.9); 2.4629 (0.6); 2.3323 (0.9); 2.3276 (1.1); 2.3229 (0.7); 2.2761 (7.4); 2.0270 (16.0); -0.0002 (14.6) I.1-278: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 12.7174 (1.1); 8.3395 (1.6); 8.3182 (1.5); 7.2541 (1.2); 7.2372 (2.9); 7.2324 (2.4); 7.2198 (7.2); 7.2061 (9.6); 7.2019 (7.3); 7.1945 (3.4); 7.1911 (3.3); 7.1858 (2.8); 7.1659 (1.3); 7.1464 (1.8); 7.1405 (1.7); 7.1311 (1.0); 7.1248 (1.1); 7.0804 (2.5); 7.0625 (1.7); 4.7166 (2.1); 4.6783 (2.2); 4.4073 (0.9); 4.3741 (0.6); 3.9794 (2.0); 3.9397 (1.8); 3.5354 (1.1); 3.3636 (1.2); 3.3131 (528.4); 3.2523 (0.6); 3.1666 (1.2); 3.0775 (1.0); 3.0665 (1.0); 3.0429 (1.4); 3.0312 (1.1); 2.8299 (1.3); 2.8050 (1.3); 2.7963 (1.2); 2.7714 (1.1); 2.6789 (1.7); 2.6743 (3.5); 2.6697 (5.0); 2.6650 (3.5); 2.6605 (1.6); 2.5918 (1.2); 2.5747 (2.8); 2.5640 (1.3); 2.5527 (3.5); 2.5400 (4.9); 2.5232 (13.4); 2.5185 (19.6); 2.5098 (276.2); 2.5052 (600.5); 2.5006 (843.5); 2.4960 (590.3); 2.4914 (260.2); 2.4472 (1.6); 2.4368 (1.6); 2.3981 (0.6); 2.3366 (1.6); 2.3320 (3.4); 2.3275 (5.0); 2.3228 (3.7); 2.3001 (0.9); 2.2799 (0.8); 2.2584 (1.3); 2.2345 (0.7); 2.2018 (0.8); 2.1909 (1.2); 2.1847 (1.5); 2.1769 (1.1); 2.1609 (1.8); 2.1501 (1.5); 2.1265 (1.6); 2.0730 (2.0); 1.8728 (0.8); 1.8530 (0.7); 1.6909 (0.9); 1.1217 (6.9); 1.1030 (16.0); 1.0841 (6.7); 0.1458 (1.1); 0.0080 (10.9); 0.0062 (3.0); 0.0054 (3.4); -0.0002 (419.6); -0.0060 (4.4); -0.0069 (3.8); -0.0085 (12.4); -0.0156 (1.2); -0.0204 (0.7); -0.1496 (1.2) I.1-280: 1 H-NMR (400.1 MHz, d6-DMSO): δ= 17.6767 (1.3); 16.6147 (1.9); 16.6008 (1.6); 12.3224 (2.0); 12.2518 (1.4); 11.4451 (1.3); 8.2865 (1.2); 7.3927 (2.5); 7.3808 (5.4); 7.3686 (5.8); 7.3604 (7.0); 7.3461 (6.6); 7.2003 (1.5); 7.1932 (6.2); 7.1709 (12.2); 7.1666 (5.1); 7.1493 (6.2); 7.1445 (5.4); 7.1211 (2.5); 5.1036 (2.0); 5.0764 (3.5); 5.0688 (1.7); 5.0583 (3.4); 5.0413 (1.9); 5.0377 (1.2); 3.9960 (1.2); 3.9788 (1.4); 3.9719 (1.3); 3.6203 (2.0); 3.6157 (1.6); 3.5967 (2.3); 3.5775 (1.5); 3.3804 (3.1); 3.3307 (519.4); 3.2798 (2.6); 3.1668 (4.0); 2.6750 (6.0); 2.6712 (7.1); 2.6660 (5.7); 2.6381 (2.6); 2.6295 (2.8); 2.5980 (3.4); 2.5900 (3.2); 2.5604 (2.9); 2.5562 (5.1); 2.5514 (6.5); 2.5470 (4.3); 2.5242 (17.1); 2.5194 (25.7); 2.5107 (465.4); 2.5062 (1018.1); 2.5017 (1408.0); 2.4971 (1005.3); 2.4927 (461.8); 2.4571 (6.7); 2.4516 (5.8); 2.4472 (4.1); 2.4169 (4.9); 2.3987 (4.5); 2.3825 (1.7); 2.3738 (4.0); 2.3590 (3.7); 2.3380 (8.9); 2.3336 (8.1); 2.3283 (7.7); 2.3242 (5.9); 2.1939 (2.0); 2.1842 (2.2); 2.1703 (4.4); 2.1603 (3.7); 2.1437 (3.0); 2.1286 (3.9); 2.1201 (4.1); 2.1032 (1.3); 2.0854 (1.4); 2.0753 (3.4); 2.0644 (1.8); 2.0545 (2.8); 2.0297 (3.2); 2.0131 (2.4); 1.9892 (1.6); 1.6894 (1.4); 1.6579 (2.6); 1.6513 (2.6); 1.6275 (1.6); 1.5830 (6.7); 1.5652 (6.7); 1.5353 (16.0); 1.5172 (15.6); 1.3476 (1.2); 0.3393 (1.2); 0.1463 (1.7); 0.0084 (8.3) I.1-282: 1 H-NMR (400.1 MHz, d 6 -DMSO): δ= 19.9309 (0.5); 16.9434 (0.6); 16.3191 (0.5); 16.2540 (0.7); 15.0797 (0.6); 12.5949 (0.6); 11.9690 (1.2); 11.9603 (1.3); 11.9296 (0.6); 11.1973 (0.6); 9.2239 (0.5); 8.2723 (1.9); 8.2527 (2.0); 7.3711 (1.6); 7.3506 (3.2); 7.3354 (3.7); 7.3312 (2.6); 7.3153 (2.2); 7.1370 (4.0); 7.1186 (5.2); 7.0899 (2.3); 7.0506 (1.7); 7.0458 (1.4); 7.0288 (2.8); 7.0086 (1.5); 7.0022 (1.4); 4.9424 (0.6); 4.9261 (1.8); 4.9076 (2.6); 4.8897 (2.0); 4.7848 (0.5); 4.7193 (3.3); 4.7055 (3.3); 3.8206 (0.9); 3.8076 (1.4); 3.7859 (1.6); 3.7793 (1.4); 3.5764 (0.6); 3.3556 (1.5); 3.3444 (1.0); 3.3060 (784.9); 3.1750 (0.8); 3.1626 (0.8); 2.6739 (1.9); 2.6689 (2.0); 2.6645 (1.7); 2.5536 (0.6); 2.5230 (3.5); 2.5180 (4.8); 2.5093 (131.4); 2.5047 (290.5); 2.5002 (407.7); 2.4956 (290.0); 2.4910 (133.9); 2.4196 (0.6); 2.4013 (0.6); 2.3432 (1.3); 2.3314 (2.7); 2.3273 (2.8); 2.3217 (2.4); 2.3055 (2.6); 2.2969 (3.0); 2.2930 (2.8); 2.2838 (2.4); 2.2675 (1.0); 2.2553 (3.5); 2.2351 (4.5); 2.2219 (2.2); 2.1980 (2.8); 2.1802 (1.4); 2.1723 (2.0); 2.1639 (1.3); 2.1565 (1.6); 2.1516 (1.2); 2.1353 (1.2); 2.1194 (0.8); 2.1115 (0.5); 2.0709 (1.2); 1.6935 (1.0); 1.6590 (1.4); 1.6431 (1.7); 1.6338 (1.4); 1.6246 (1.1); 1.6088 (0.9); 1.5736 (0.8); 1.5506 (1.4); 1.5356 (1.7); 1.5156 (1.6); 1.5031 (0.9); 1.4952 (0.9); 1.4791 (0.7); 1.3276 (15.8); 1.3101 (16.0); 1.2351 (0.6); 0.1467 (0.6); 0.0078 (2.1) I.1-283: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.1442 (2.1); 7.1238 (7.3); 7.1119 (3.4); 7.1044 (4.1); 7.0852 (1.7); 7.0616 (0.8); 4.7118 (0.6); 4.6744 (0.7); 4.6221 (0.6); 4.5910 (0.7); 4.5177 (0.6); 4.4877 (0.7); 4.1884 (0.9); 4.0780 (0.8); 4.0405 (0.7); 3.9924 (0.7); 3.7313 (0.8); 3.6440 (0.8); 3.6195 (0.7); 3.4882 (1.4); 3.3733 (218.5); 3.1679 (2.5); 2.7418 (0.8); 2.6750 (1.6); 2.6702 (2.3); 2.6656 (1.8); 2.5405 (0.8); 2.5236 (5.2); 2.5189 (7.5); 2.5103 (118.5); 2.5057 (260.9); 2.5011 (365.3); 2.4965 (254.0); 2.4919 (113.7); 2.4559 (1.6); 2.4511 (2.0); 2.4465 (1.5); 2.3859 (1.0); 2.3473 (1.0); 2.3325 (1.9); 2.3279 (2.6); 2.3233 (2.0); 2.2749 (16.0); 2.2381 (1.4); 2.0727 (2.1); 1.9136 (1.6); 1.8673 (1.4); 1.8488 (1.7); 1.6495 (0.8); 1.0627 (0.6); -0.0002 (14.8) I.1-284: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 12.2226 (1.3); 8.4673 (1.8); 8.4522 (3.3); 8.4376 (1.8); 7.9438 (1.0); 7.9228 (1.2); 7.8145 (1.5); 7.7926 (15.1); 7.7881 (5.3); 7.7761 (5.5); 7.7715 (16.0); 7.6553 (1.0); 7.6339 (0.9); 7.4330 (13.6); 7.4118 (12.3); 5.6780 (0.8); 5.6629 (1.4); 5.6391 (2.7); 5.6242 (9.3); 5.6211 (5.0); 5.6158 (3.3); 5.6104 (4.8); 5.6074 (9.7); 5.5926 (3.3); 5.5853 (1.4); 5.5813 (1.9); 5.5772 (1.2); 5.5714 (1.3); 5.5688 (1.8); 5.5540 (0.9); 4.7066 (0.5); 4.6662 (0.6); 4.3367 (11.4); 4.3216 (11.2); 4.2817 (0.6); 4.2423 (0.6); 4.1569 (0.5); 4.1437 (0.5); 3.3412 (37.7); 3.0073 (10.6); 3.0045 (9.4); 2.9997 (5.5); 2.9940 (14.2); 2.9505 (11.6); 2.9368 (9.4); 2.6751 (0.8); 2.6703 (1.2); 2.6387 (0.5); 2.6287 (0.6); 2.5237 (3.7); 2.5188 (5.6); 2.5103 (57.2); 2.5058 (118.6); 2.5012 (161.2); 2.4966 (114.3); 2.4921 (52.3); 2.4672 (0.8); 2.4613 (0.9); 2.4177 (0.6); 2.3938 (0.6); 2.3492 (0.7); 2.3373 (0.7); 2.3326 (1.0); 2.3277 (1.4); 2.3233 (1.0); 2.3092 (0.7); 2.2961 (0.5); 2.2870 (0.6); 2.2825 (0.5); -0.0002 (6.6) I.1-285: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 7.8174 (0.6); 7.7987 (0.5); 7.3539 (0.6); 7.3317 (0.6); 7.1883 (0.6); 7.1846 (0.7); 7.1722 (0.7); 7.0709 (0.6); 7.0548 (0.9); 4.7290 (1.0); 4.6893 (1.2); 4.2374 (1.3); 4.1974 (1.1); 3.8137 (0.6); 3.8078 (0.5); 3.7974 (1.3); 3.7873 (0.9); 3.7785 (1.2); 3.7669 (0.6); 3.7624 (0.6); 3.3212 (46.0); 2.5232 (0.5); 2.5185 (0.8); 2.5098 (16.1); 2.5053 (35.6); 2.5007 (49.9); 2.4961 (35.5); 2.4916 (16.4); 2.4664 (1.1); 2.4543 (1.1); 2.4317 (1.2); 2.4197 (1.1); 2.3571 (0.8); 2.3372 (0.8); 2.3149 (0.6); 2.2867 (0.6); 2.2733 (0.7); 2.2628 (0.8); 2.2493 (0.8); 2.1643 (1.2); 2.1435 (1.3); 2.1295 (1.1); 2.1086 (1.2); 2.1026 (0.5); 2.0950 (0.7); 2.0710 (0.5); 1.7451 (0.5); 1.0207 (16.0); 1.0042 (15.9); -0.0002 (11.0) I.1-286: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.3796 (0.9); 7.3589 (2.2); 7.3373 (2.2); 7.3163 (1.1); 7.2081 (1.1); 7.1992 (1.0); 7.1918 (2.0); 7.1883 (2.2); 7.1759 (2.2); 7.1718 (1.7); 7.1679 (1.6); 7.1555 (1.2); 7.0969 (1.2); 7.0810 (2.2); 7.0612 (1.6); 7.0452 (0.7); 5.0694 (1.0); 5.0605 (1.9); 5.0476 (1.1); 4.7892 (1.5); 4.7757 (1.2); 4.7526 (3.0); 4.7392 (1.2); 4.7151 (2.0); 4.3019 (0.7); 4.2884 (1.6); 4.2643 (2.0); 4.2487 (1.4); 4.2375 (1.0); 4.2240 (1.7); 4.1958 (0.9); 4.1811 (0.7); 4.1674 (1.5); 4.1500 (2.2); 4.1354 (1.5); 4.1327 (2.0); 4.1301 (2.4); 4.1230 (2.0); 4.1177 (1.6); 4.1123 (4.3); 4.1099 (3.6); 4.1052 (5.6); 4.0945 (3.7); 4.0921 (3.4); 4.0874 (5.6); 4.0766 (1.2); 4.0697 (1.8); 3.8576 (0.9); 3.8485 (1.0); 3.8383 (0.9); 3.8264 (0.9); 3.8153 (0.9); 3.8046 (0.9); 3.7932 (0.9); 3.7838 (1.2); 3.7744 (1.0); 3.7392 (1.0); 3.7061 (0.6); 3.3521 (0.9); 3.3172 (207.4); 3.2934 (5.9); 3.0627 (0.5); 3.0443 (0.6); 3.0371 (0.8); 3.0305 (0.8); 3.0197 (0.9); 3.0124 (0.9); 2.9876 (0.6); 2.9416 (6.9); 2.8973 (1.1); 2.8866 (0.9); 2.8652 (0.6); 2.8568 (1.4); 2.8461 (1.1); 2.8392 (0.9); 2.8289 (0.9); 2.7991 (1.1); 2.7894 (1.0); 2.6748 (0.8); 2.6701 (1.2); 2.6655 (0.9); 2.5986 (1.2); 2.5908 (1.5); 2.5766 (1.8); 2.5588 (1.2); 2.5451 (0.8); 2.5404 (1.4); 2.5361 (1.3); 2.5236 (2.0); 2.5189 (3.7); 2.5102 (68.7); 2.5056 (152.9); 2.5010 (215.3); 2.4964 (151.0); 2.4918 (68.4); 2.4813 (3.5); 2.4730 (2.5); 2.4684 (2.0); 2.4633 (1.6); 2.4509 (0.7); 2.4409 (1.8); 2.4314 (1.4); 2.4183 (1.3); 2.4001 (2.0); 2.3778 (1.2); 2.3572 (0.8); 2.3374 (1.0); 2.3325 (1.3); 2.3278 (1.5); 2.3231 (1.3); 2.3188 (1.1); 2.3012 (0.7); 2.2777 (1.3); 2.2696 (0.9); 2.2652 (1.1); 2.2574 (1.0); 2.2533 (1.7); 2.2450 (1.4); 2.2412 (1.8); 2.2333 (1.3); 2.2119 (1.6); 2.2046 (1.9); 2.1925 (1.5); 2.1798 (0.8); 2.1708 (1.4); 2.1606 (1.4); 2.1471 (1.5); 2.1402 (1.6); 2.1158 (1.4); 2.0963 (1.5); 2.0734 (1.0); 2.0620 (1.3); 1.7125 (0.6); 1.7002 (0.6); 1.6875 (1.1); 1.6820 (1.0); 1.6576 (1.7); 1.6468 (2.1); 1.6148 (2.6); 1.6051 (2.5); 1.5825 (1.9); 1.5442 (0.8); 1.5292 (0.9); 1.5100 (1.1); 1.5010 (0.8); 1.4936 (0.8); 1.4776 (0.7); 1.4685 (0.5); 1.3801 (0.5); 1.3479 (0.6); 1.2847 (0.5); 1.2518 (0.9); 1.2432 (1.4); 1.2254 (2.3); 1.2148 (4.8); 1.2076 (1.8); 1.1970 (9.6); 1.1944 (8.8); 1.1889 (4.5); 1.1821 (8.5); 1.1793 (6.2); 1.1766 (16.0); 1.1712 (7.7); 1.1644 (15.5); 1.1588 (7.6); 1.1534 (3.7); 1.1466 (6.8); -0.0002 (2.2) I.1-287: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 7.1873 (0.5); 7.1808 (2.0); 7.1728 (7.6); 7.1681 (4.3); 7.1632 (1.2); 7.1559 (1.7); 7.1506 (0.7); 7.1436 (1.2); 7.1094 (1.5); 7.0968 (1.2); 7.0909 (0.6); 4.7105 (1.7); 4.6711 (2.0); 4.0769 (1.8); 4.0375 (1.6); 3.9636 (1.1); 3.6728 (0.7); 3.6629 (0.7); 3.6590 (0.6); 3.6528 (0.8); 3.6496 (0.9); 3.6437 (0.6); 3.6394 (0.8); 3.6297 (0.8); 3.5374 (1.7); 3.5051 (1.3); 3.1673 (9.4); 2.6773 (1.2); 2.6681 (1.3); 2.6377 (1.5); 2.6284 (1.5); 2.5233 (0.5); 2.5186 (0.8); 2.5100 (11.6); 2.5054 (25.4); 2.5008 (35.5); 2.4962 (24.9); 2.4916 (11.3); 2.4555 (0.6); 2.4514 (0.7); 2.4318 (0.9); 2.4113 (0.9); 2.3898 (0.6); 2.3573 (1.7); 2.3339 (1.7); 2.3178 (1.5); 2.3049 (0.7); 2.2941 (1.9); 2.2803 (1.1); 2.2687 (1.0); 2.2387 (0.8); 2.2242 (16.0); 2.2087 (0.6); 2.1895 (0.8); 2.1777 (0.6); 2.1650 (0.5); 2.1579 (0.8); 2.1334 (0.6); 1.7506 (0.6); 1.7289 (0.7); 1.7194 (0.7); -0.0002 (8.4) I.1-288: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 12.4475 (0.8); 8.1332 (1.0); 8.1120 (1.3); 8.0881 (0.9); 7.2016 (1.9); 7.1811 (3.9); 7.1444 (3.4); 7.1241 (1.7); 4.6852 (1.0); 4.6455 (1.1); 4.3392 (0.6); 4.3224 (0.6); 4.1931 (0.6); 3.9904 (1.2); 3.9516 (1.0); 3.6687 (0.5); 3.3215 (161.4); 3.1672 (7.5); 2.8755 (0.7); 2.8584 (1.0); 2.8416 (0.8); 2.6789 (1.3); 2.6743 (3.0); 2.6697 (4.2); 2.6651 (2.8); 2.6604 (1.2); 2.5232 (12.6); 2.5184 (18.3); 2.5098 (240.9); 2.5052 (517.3); 2.5006 (719.5); 2.4960 (504.1); 2.4914 (224.8); 2.4655 (0.7); 2.4499 (1.4); 2.4454 (1.4); 2.3367 (1.8); 2.3319 (3.3); 2.3274 (4.6); 2.3227 (3.8); 2.2996 (0.7); 2.2370 (0.7); 2.2235 (0.7); 2.1886 (0.9); 2.1640 (0.7); 2.1545 (0.7); 2.1305 (0.6); 2.0731 (4.5); 1.9650 (0.6); 1.7248 (0.5); 1.5995 (0.8); 1.5825 (0.8); 1.5650 (0.9); 1.5311 (0.7); 1.5017 (0.9); 1.4885 (0.9); 1.4658 (0.8); 1.4320 (1.3); 1.4141 (1.4); 1.1936 (16.0); 1.1763 (15.8); 0.8866 (5.4); 0.8798 (5.2); 0.8704 (5.8); 0.8632 (5.7); 0.8467 (1.3); 0.8333 (4.8); 0.8173 (8.7); 0.8015 (4.7); 0.7796 (1.0); 0.1460 (0.8); 0.0080 (7.6); -0.0002 (278.8); -0.0085 (8.7); -0.1497 (1.0) I.1-290: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.4076 (1.4); 7.4012 (11.5); 7.3965 (4.0); 7.3850 (4.6); 7.3801 (16.0); 7.3739 (2.1); 7.2602 (12.3); 7.2390 (9.2); 7.2038 (3.0); 7.0722 (6.5); 6.9405 (3.3); 4.6044 (4.3); 4.5654 (5.0); 4.1446 (5.0); 4.1056 (4.4); 3.8098 (1.1); 3.7993 (1.8); 3.7887 (2.4); 3.7782 (2.7); 3.7682 (2.5); 3.7577 (2.0); 3.7474 (1.2); 3.7311 (0.6); 3.7202 (0.6); 3.6832 (0.5); 3.5964 (0.7); 3.5503 (2.5); 3.1697 (0.5); 2.8085 (2.6); 2.7981 (2.7); 2.7689 (3.3); 2.7586 (3.2); 2.5240 (0.5); 2.5192 (0.9); 2.5106 (19.6); 2.5061 (42.3); 2.5015 (58.4); 2.4969 (42.5); 2.4923 (20.8); 2.4670 (0.7); 2.4529 (3.8); 2.4474 (1.3); 2.4426 (1.4); 2.4309 (3.3); 2.4239 (1.7); 2.4136 (3.1); 2.4001 (2.6); 2.3914 (2.8); 2.3818 (2.4); 2.3771 (2.1); 2.3585 (1.9); 2.3281 (0.5); 2.3008 (1.6); 2.2875 (2.0); 2.2765 (2.5); 2.2632 (2.6); 2.2461 (0.9); 2.2346 (1.5); 2.2219 (1.6); 2.1901 (1.0); 2.1712 (1.6); 2.1664 (1.0); 2.1587 (1.3); 2.1523 (1.2); 2.1469 (1.4); 2.1398 (1.9); 2.1347 (1.2); 2.1282 (0.9); 2.1204 (1.2); 2.1153 (1.4); 2.0962 (0.7); 1.7316 (0.8); 1.7197 (1.3); 1.7084 (1.7); 1.6978 (1.6); 1.6880 (1.6); 1.6766 (1.6); 1.6652 (1.1); 1.6525 (0.7); -0.0002 (18.5); -0.0085 (0.8) I.1-291: 1 H-NMR (400.1 MHz, CDCl 3 ): δ= 7.2620 (21.2); 7.2599 (23.3); 7.1516 (0.6); 7.1301 (2.8); 7.1098 (6.7); 7.0917 (2.5); 7.0840 (6.6); 7.0640 (2.6); 5.2993 (2.5); 5.2973 (2.7); 4.8264 (2.0); 4.7888 (2.2); 4.6068 (0.3); 4.0072 (2.2); 3.9694 (2.1); 3.9557 (0.7); 3.9460 (1.1); 3.9360 (1.2); 3.9259 (1.1); 3.9161 (0.7); 3.9060 (0.4); 3.2797 (0.4); 3.2626 (0.3); 2.8558 (0.6); 2.8306 (0.6); 2.8164 (2.0); 2.7968 (1.2); 2.7856 (1.2); 2.7567 (1.5); 2.7458 (1.5); 2.5760 (1.8); 2.5564 (2.1); 2.5353 (2.0); 2.5154 (1.9); 2.4901 (0.9); 2.4784 (0.9); 2.4667 (1.1); 2.4542 (1.2); 2.4421 (1.2); 2.4234 (0.4); 2.4107 (0.6); 2.3988 (0.5); 2.3339 (1.2); 2.3176 (16.0); 2.2898 (0.6); 2.2680 (0.8); 2.2564 (0.6); 2.2454 (0.8); 2.2353 (0.9); 2.2245 (0.4); 2.2121 (0.8); 1.8761 (0.4); 1.8654 (0.7); 1.8539 (0.7); 1.8426 (0.9); 1.8322 (0.9); 1.8212 (0.6); 1.8095 (0.6); 1.7988 (0.4); 1.2594 (0.3); 1.1924 (0.5); 1.1730 (0.9); 1.1553 (0.4); 0.0020 (5.5) I.1-292: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.8237 (3.9); 7.3694 (0.8); 7.3653 (0.8); 7.3494 (0.6); 7.3435 (0.8); 7.1987 (0.8); 7.1952 (0.9); 7.1862 (0.8); 7.1829 (0.9); 7.1787 (0.6); 7.1749 (0.6); 7.1069 (0.7); 7.0906 (1.0); 7.0716 (0.6); 4.7754 (1.1); 4.7358 (1.3); 4.2921 (1.6); 4.2524 (1.5); 4.0350 (0.7); 3.9146 (0.6); 3.9045 (0.9); 3.8936 (1.1); 3.8843 (1.2); 3.8731 (1.0); 3.8630 (0.8); 3.5986 (16.0); 3.1667 (0.7); 2.8870 (0.6); 2.8770 (0.6); 2.8495 (0.7); 2.8398 (0.7); 2.7718 (0.5); 2.5541 (0.8); 2.5310 (1.0); 2.5236 (1.6); 2.5188 (2.6); 2.5102 (27.6); 2.5057 (58.6); 2.5011 (81.0); 2.4965 (57.0); 2.4919 (25.9); 2.4689 (0.6); 2.4270 (1.0); 2.4082 (0.9); 2.4043 (0.8); 2.3867 (0.6); 2.3279 (1.1); 2.3151 (0.7); 2.3035 (1.0); 2.2909 (1.0); 2.2618 (0.7); 2.2515 (1.1); 2.2347 (0.7); 2.2227 (0.6); 2.2038 (0.8); 2.1793 (0.5); 1.8635 (0.5); 1.8521 (0.6); 1.8414 (0.6); 1.8340 (0.6); 0.0080 (1.1); -0.0002 (35.3); -0.0085 (1.0) I.1-293: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 12.4987 (1.2); 8.2519 (1.7); 8.2321 (1.6); 7.2274 (1.6); 7.2231 (2.1); 7.2129 (4.3); 7.2094 (6.0); 7.1972 (0.8); 7.1738 (1.0); 7.1677 (0.9); 7.1550 (2.0); 7.1479 (2.0); 7.1411 (1.3); 7.1268 (2.7); 7.1091 (0.9); 4.7638 (2.3); 4.7248 (2.5); 4.1909 (0.6); 4.1707 (1.0); 4.1548 (1.1); 4.1333 (0.7); 4.0633 (2.1); 4.0242 (1.9); 3.6789 (0.6); 3.6562 (1.0); 3.6338 (0.6); 3.3120 (147.6); 2.6790 (0.7); 2.6744 (1.4); 2.6697 (2.0); 2.6651 (1.5); 2.6605 (0.6); 2.6292 (1.0); 2.6104 (2.8); 2.6062 (2.7); 2.5916 (2.7); 2.5877 (2.8); 2.5717 (2.1); 2.5616 (1.4); 2.5489 (0.8); 2.5399 (2.5); 2.5378 (2.4); 2.5233 (6.1); 2.5185 (8.6); 2.5098 (112.3); 2.5053 (243.0); 2.5006 (338.8); 2.4960 (236.7); 2.4914 (104.2); 2.4700 (0.7); 2.4504 (0.6); 2.4458 (0.6); 2.4376 (0.7); 2.4145 (1.0); 2.3955 (0.9); 2.3732 (1.4); 2.3509 (0.8); 2.3369 (0.7); 2.3321 (1.4); 2.3274 (2.0); 2.3228 (1.4); 2.3181 (0.7); 2.2897 (0.8); 2.2796 (1.0); 2.2655 (1.2); 2.2553 (1.1); 2.2480 (0.8); 2.2383 (1.9); 2.2237 (0.7); 2.2148 (1.9); 2.2045 (1.4); 2.1808 (1.2); 2.0731 (0.6); 2.0430 (0.7); 2.0316 (0.6); 2.0203 (0.7); 2.0094 (0.9); 1.9888 (0.8); 1.8419 (0.6); 1.8329 (0.5); 1.8195 (0.9); 1.8097 (0.9); 1.6112 (0.6); 1.5952 (0.8); 1.5795 (0.7); 1.5058 (1.5); 1.4987 (1.6); 1.4929 (1.3); 1.4833 (2.7); 1.4693 (1.2); 1.4621 (1.2); 1.1437 (6.9); 1.1250 (16.0); 1.1061 (6.6); 0.8940 (9.8); 0.8776 (9.5); 0.8266 (9.9); 0.8104 (9.7); 0.1459 (0.5); 0.0118 (0.5); 0.0080 (5.2); 0.0063 (1.5); 0.0055 (1.8); 0.0047 (2.1); -0.0002 (181.9); -0.0051 (2.5); -0.0060 (1.9); -0.0068 (1.7); -0.0085 (5.3); -0.0107 (1.0); -0.0115 (0.8); -0.0140 (0.5); -0.1497 (0.6) I.1-294: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.3499 (1.7); 8.3286 (1.7); 7.2815 (1.7); 7.2634 (4.1); 7.2607 (3.0); 7.2509 (1.5); 7.2457 (4.9); 7.2175 (6.6); 7.2003 (3.8); 7.1866 (2.4); 7.1691 (0.9); 7.1272 (3.2); 7.1072 (7.0); 7.0806 (7.1); 7.0600 (3.1); 7.0365 (0.5); 4.6001 (1.9); 4.5618 (2.3); 4.4842 (0.6); 4.4731 (0.8); 4.4594 (1.1); 4.4517 (0.9); 4.4383 (0.8); 4.4276 (0.8); 3.9908 (2.2); 3.9529 (1.9); 3.5914 (1.0); 3.5805 (1.0); 3.3813 (10.8); 3.1637 (1.8); 3.0918 (1.1); 3.0791 (1.2); 3.0563 (1.4); 3.0453 (1.3); 2.8284 (1.4); 2.8027 (1.5); 2.7936 (1.2); 2.7679 (1.0); 2.6744 (1.2); 2.6697 (1.6); 2.6651 (1.2); 2.5378 (1.3); 2.5333 (2.5); 2.5232 (5.3); 2.5185 (6.9); 2.5098 (94.1); 2.5052 (204.3); 2.5006 (283.4); 2.4960 (195.9); 2.4914 (86.0); 2.4658 (0.8); 2.4563 (1.7); 2.4443 (1.7); 2.3320 (1.2); 2.3274 (1.5); 2.3227 (1.1); 2.2670 (16.0); 2.2497 (1.2); 2.2304 (1.2); 2.2072 (0.9); 2.1834 (1.1); 2.1701 (1.2); 2.1595 (1.3); 2.1455 (1.2); 2.1284 (0.7); 2.1177 (0.7); 2.0931 (1.6); 2.0699 (1.4); 2.0585 (1.3); 2.0361 (1.2); 1.7645 (0.7); 1.7403 (0.8); 1.7322 (0.9); 1.7085 (0.8); 1.3834 (0.8); 1.3738 (0.7); 1.3506 (0.6); 0.0328 (0.6); 0.0080 (2.8); 0.0055 (1.2); 0.0047 (1.3); 0.0023 (4.2); - 0.0002 (91.0); -0.0027 (4.6); -0.0052 (1.0); -0.0068 (0.7); -0.0085 (2.4) I.1-295: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 11.8188 (0.8); 7.1858 (5.3); 7.1754 (8.0); 7.1478 (1.2); 7.0934 (1.2); 7.0862 (0.9); 7.0722 (0.9); 4.7125 (1.1); 4.6892 (0.8); 4.6726 (1.0); 4.6494 (0.9); 4.0782 (1.2); 4.0550 (1.5); 4.0385 (1.4); 4.0151 (1.5); 3.8680 (2.2); 3.7796 (2.2); 3.7433 (2.0); 3.7328 (2.0); 3.6115 (1.0); 3.5938 (1.2); 3.5682 (1.1); 3.5501 (0.9); 3.4235 (0.5); 3.2303 (3.3); 3.1896 (10.3); 3.1783 (2.4); 3.1672 (2.2); 3.1479 (1.5); 3.1299 (1.3); 3.1086 (1.3); 3.0868 (1.1); 3.0423 (0.9); 3.0278 (1.7); 3.0034 (1.0); 2.9899 (0.8); 2.9558 (0.8); 2.7659 (6.0); 2.7539 (5.7); 2.7268 (0.7); 2.7164 (0.7); 2.6886 (0.9); 2.6786 (1.0); 2.6745 (1.3); 2.6699 (1.6); 2.6653 (1.1); 2.5233 (2.9); 2.5186 (4.7); 2.5099 (77.6); 2.5053 (170.7); 2.5007 (240.2); 2.4961 (170.6); 2.4916 (78.3); 2.4508 (1.4); 2.4461 (1.4); 2.4274 (1.5); 2.4050 (1.3); 2.3956 (1.1); 2.3894 (1.1); 2.3673 (0.9); 2.3321 (1.6); 2.3274 (2.2); 2.3231 (2.0); 2.3125 (1.4); 2.2994 (1.6); 2.2886 (1.4); 2.2474 (3.0); 2.2305 (16.0); 2.1951 (0.9); 2.1837 (0.8); 2.1710 (0.9); 2.1499 (0.6); 2.0731 (0.5); 1.8163 (0.7); 1.7968 (0.9); 1.7775 (0.8); 1.7607 (0.8); 1.7509 (0.7); 1.7372 (0.7); 1.7283 (0.6); 1.7065 (0.5); 1.1869 (1.4); 1.1756 (1.5); 1.1325 (0.7); 1.0641 (2.4); 1.0461 (5.3); 1.0281 (2.4); 0.0080 (1.2); -0.0002 (43.6); -0.0085 (1.4) I.1-296: 1 H-NMR (400.0 MHz, CDCl 3 ): δ= 7.5204 (1.0); 7.2615 (178.9); 7.2514 (2.9); 7.2467 (2.4); 7.2382 (1.8); 7.2328 (4.2); 7.2278 (3.5); 7.2130 (4.7); 7.2081 (3.1); 7.1994 (2.4); 7.1946 (3.0); 7.1900 (3.0); 7.1854 (2.8); 7.1710 (6.9); 7.1665 (6.2); 7.1522 (4.7); 7.1476 (3.8); 7.1180 (1.4); 7.1022 (7.5); 7.0995 (8.0); 7.0932 (5.0); 7.0837 (10.5); 7.0810 (11.6); 7.0677 (6.4); 7.0622 (5.3); 7.0490 (15.2); 7.0426 (11.4); 7.0384 (8.2); 7.0337 (16.0); 7.0254 (10.9); 7.0148 (1.5); 7.0062 (4.7); 6.9976 (1.3); 5.4657 (3.0); 4.8462 (6.0); 4.8429 (6.1); 4.8075 (6.8); 4.8041 (6.9); 4.2303 (8.8); 4.1916 (7.7); 3.9338 (1.4); 3.9230 (2.9); 3.9120 (3.7); 3.9016 (4.0); 3.8918 (3.6); 3.8809 (3.0); 3.8699 (1.4); 3.5661 (0.5); 3.5490 (1.3); 3.5326 (3.5); 3.5156 (8.7); 3.4996 (12.2); 3.4835 (9.0); 3.4671 (3.5); 3.4499 (1.4); 3.4337 (0.5); 2.8632 (8.2); 2.8462 (15.7); 2.8292 (7.4); 2.5900 (5.8); 2.5792 (5.8); 2.5539 (6.8); 2.5431 (6.7); 2.5146 (1.3); 2.4955 (1.7); 2.4910 (1.6); 2.4715 (4.6); 2.4524 (4.0); 2.4483 (4.0); 2.4292 (3.9); 2.4132 (4.1); 2.3986 (4.6); 2.3890 (5.5); 2.3746 (5.6); 2.3559 (1.6); 2.3460 (2.5); 2.3318 (2.5); 2.2578 (2.1); 2.2386 (3.4); 2.2340 (1.9); 2.2250 (2.5); 2.2196 (2.1); 2.2146 (2.8); 2.2060 (3.9); 2.2010 (2.3); 2.1957 (1.6); 2.1867 (2.2); 2.1818 (3.0); 2.1626 (1.4); 2.1191 (7.2); 2.0965 (7.1); 2.0831 (6.3); 2.0604 (6.2); 1.8139 (2.2); 1.7998 (2.7); 1.7893 (3.4); 1.7796 (3.3); 1.7662 (3.4); 1.7560 (3.2); 1.7460 (2.8); 1.7317 (2.7); 0.0078 (1.5); -0.0002 (46.8); -0.0084 (1.6) I.1-298: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.3558 (0.8); 7.3347 (0.8); 7.1868 (0.8); 7.1740 (0.8); 7.1701 (0.7); 7.1663 (0.5); 7.0966 (0.6); 7.0806 (0.8); 4.7607 (0.9); 4.7213 (1.0); 4.7000 (0.5); 4.2677 (1.1); 4.2286 (1.0); 4.2047 (2.5); 4.1741 (0.5); 4.0381 (3.8); 4.0344 (3.7); 3.8308 (0.6); 3.8210 (0.7); 3.8112 (0.7); 3.8017 (0.6); 3.6734 (7.7); 3.6200 (16.0); 3.4115 (14.4); 3.1660 (1.4); 2.9682 (14.8); 2.8500 (0.6); 2.8396 (0.6); 2.8092 (0.9); 2.7991 (0.8); 2.7689 (5.6); 2.6743 (1.0); 2.6699 (1.2); 2.6652 (0.8); 2.5695 (1.0); 2.5554 (0.6); 2.5507 (0.8); 2.5469 (1.2); 2.5401 (0.8); 2.5286 (1.8); 2.5233 (3.2); 2.5186 (4.7); 2.5099 (61.2); 2.5053 (131.9); 2.5007 (182.5); 2.4961 (127.8); 2.4916 (57.4); 2.4327 (0.7); 2.4087 (0.8); 2.3961 (0.5); 2.3322 (0.9); 2.3275 (1.2); 2.3229 (0.8); 2.2562 (0.5); 2.2432 (0.8); 2.2316 (0.8); 2.2019 (0.6); 2.1948 (1.2); 2.1792 (0.6); 2.1479 (0.7); 0.0080 (2.4); -0.0002 (81.5); -0.0085 (2.4) I.1-299: 1 H-NMR (400.1 MHz, d6-DMSO): δ= 7.6319 (0.3); 3.3264 (16.0); 2.7602 (3.9); 2.5096 (2.8); 2.5051 (6.0); 2.5005 (8.5); 2.4959 (6.2); 2.4913 (3.0) I.1-301: 1 H-NMR (400.0 MHz, CDCl3): δ= 7.2611 (68.1); 7.2065 (0.8); 7.2018 (0.7); 7.1855 (1.6); 7.1809 (0.6); 7.1692 (0.7); 7.1646 (1.0); 7.1483 (0.5); 7.1125 (25.7); 6.8810 (2.0); 6.8614 (2.6); 6.8413 (1.7); 5.3513 (0.6); 4.6990 (1.8); 4.6615 (2.1); 4.1199 (1.9); 4.0824 (1.6); 3.9310 (0.7); 3.9202 (0.8); 3.9098 (1.0); 3.9001 (0.8); 3.8893 (0.7); 3.4923 (0.8); 3.4757 (1.2); 3.4592 (1.1); 3.4222 (1.0); 3.4067 (1.1); 3.3899 (0.7); 2.8688 (1.2); 2.8545 (2.2); 2.8521 (2.2); 2.8380 (1.0); 2.8353 (1.0); 2.5024 (1.3); 2.4912 (1.5); 2.4724 (1.0); 2.4662 (1.5); 2.4548 (2.1); 2.4305 (0.7); 2.4127 (0.9); 2.3984 (1.0); 2.3884 (1.1); 2.3743 (1.2); 2.3456 (0.6); 2.3314 (0.7); 2.3213 (16.0); 2.1863 (0.7); 2.1730 (0.5); 2.1621 (0.7); 2.1537 (0.8); 2.1488 (0.5); 2.1342 (0.5); 2.1293 (0.7); 2.0619 (1.6); 2.0400 (1.6); 2.0257 (1.4); 2.0038 (1.4); 1.7392 (0.5); 1.7286 (0.7); 1.7188 (0.6); 1.7057 (0.6); 1.6954 (0.6); -0.0002 (18.6); -0.0085 (0.6) I.1-302: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.0108 (1.0); 8.0010 (1.0); 7.2249 (1.5); 7.2213 (1.7); 7.2130 (2.7); 7.2099 (4.1); 7.2070 (6.2); 7.1946 (0.7); 7.1765 (1.1); 7.1697 (1.0); 7.1576 (1.6); 7.1503 (1.6); 7.1432 (0.9); 7.1359 (1.0); 7.1000 (2.3); 7.0819 (1.4); 4.7470 (2.1); 4.7078 (2.4); 4.0548 (2.1); 4.0155 (1.9); 3.7070 (0.6); 3.6971 (0.9); 3.6863 (1.1); 3.6757 (0.9); 3.6658 (0.5); 3.5009 (5.9); 2.6237 (0.9); 2.6046 (3.0); 2.5942 (1.0); 2.5859 (3.7); 2.5762 (1.5); 2.5665 (2.2); 2.5483 (0.9); 2.5457 (0.7); 2.5402 (0.7); 2.5234 (1.0); 2.5187 (1.5); 2.5100 (23.2); 2.5055 (50.9); 2.5008 (71.4); 2.4962 (49.7); 2.4916 (22.1); 2.4379 (1.3); 2.4269 (1.3); 2.4029 (1.6); 2.3916 (1.9); 2.3685 (0.9); 2.3473 (1.4); 2.3243 (0.9); 2.2847 (0.8); 2.2734 (1.0); 2.2603 (1.2); 2.2493 (1.2); 2.2426 (0.6); 2.2316 (0.6); 2.2183 (0.6); 2.2074 (0.6); 2.1282 (1.7); 2.1060 (1.8); 2.0932 (1.5); 2.0819 (0.8); 2.0710 (1.9); 2.0584 (0.7); 2.0498 (0.9); 2.0264 (0.7); 1.7374 (0.6); 1.7285 (0.5); 1.7247 (0.5); 1.7158 (0.9); 1.7052 (0.9); 1.1446 (6.8); 1.1259 (16.0); 1.1070 (6.7); 0.6058 (0.9); 0.5936 (2.7); 0.5883 (3.6); 0.5759 (3.4); 0.5704 (3.0); 0.5584 (1.2); 0.3497 (1.3); 0.3397 (3.2); 0.3334 (2.8); 0.3284 (2.7); 0.3234 (2.8); 0.3115 (1.1); -0.0002 (5.5) I.1-303: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 11.8166 (10.6); 8.0474 (2.6); 7.3838 (2.8); 7.3668 (5.4); 7.3424 (5.8); 7.3215 (3.5); 7.2101 (3.3); 7.1938 (5.9); 7.1782 (5.8); 7.1616 (3.6); 7.0731 (5.9); 7.0571 (7.6); 7.0409 (5.2); 7.0210 (2.4); 4.7204 (8.1); 4.6804 (9.2); 4.2464 (9.6); 4.2071 (8.5); 3.8462 (3.6); 3.8357 (4.9); 3.8259 (5.5); 3.8153 (4.6); 3.4014 (5.1); 3.3446 (566.1); 3.2334 (18.4); 3.2120 (111.6); 3.1658 (16.0); 2.7482 (7.1); 2.7376 (6.2); 2.7098 (7.4); 2.6993 (7.2); 2.6744 (15.0); 2.6698 (20.9); 2.6651 (14.7); 2.5623 (7.1); 2.5573 (5.4); 2.5232 (52.8); 2.5185 (81.7); 2.5098 (1173.9); 2.5053 (2552.9); 2.5007 (3561.7); 2.4961 (2494.2); 2.4915 (1123.6); 2.4606 (20.4); 2.4561 (23.2); 2.4514 (20.1); 2.4467 (9.1); 2.4375 (5.1); 2.4156 (10.0); 2.3988 (13.9); 2.3777 (12.1); 2.3564 (6.2); 2.3368 (8.4); 2.3322 (16.6); 2.3274 (22.3); 2.3229 (16.4); 2.3184 (8.5); 2.3038 (6.0); 2.2920 (5.8); 2.2800 (7.4); 2.2676 (7.2); 2.2381 (4.8); 2.2236 (5.9); 2.2047 (6.5); 2.1934 (4.4); 2.1741 (5.6); 2.1503 (4.3); 2.0732 (6.3); 1.7786 (3.5); 1.7677 (3.7); 1.7488 (4.5); 1.7241 (2.8); 1.1327 (2.5); 0.1461 (5.4); 0.0080 (44.0); -0.0002 (1593.3); -0.0086 (48.3); -0.0496 (8.1); -0.1495 (5.3) I.1-304: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 7.3794 (0.9); 7.3592 (1.9); 7.3374 (2.0); 7.3160 (0.9); 7.2080 (1.0); 7.1881 (2.0); 7.1756 (1.9); 7.1557 (1.0); 7.0970 (1.2); 7.0810 (1.8); 7.0623 (1.4); 5.0609 (1.7); 4.7885 (1.4); 4.7758 (1.1); 4.7522 (2.6); 4.7150 (1.7); 4.2886 (1.4); 4.2643 (1.8); 4.2493 (1.2); 4.2381 (0.8); 4.2230 (1.5); 4.1983 (0.7); 4.1804 (0.7); 4.1671 (1.3); 4.1498 (1.8); 4.1302 (2.2); 4.1228 (1.7); 4.1122 (3.7); 4.1050 (4.8); 4.0945 (3.2); 4.0873 (4.6); 4.0764 (1.0); 4.0694 (1.4); 3.8482 (1.0); 3.8147 (0.8); 3.7834 (1.1); 3.7395 (1.0); 3.7053 (0.6); 3.4581 (16.0); 3.1667 (1.2); 3.0383 (0.8); 3.0128 (0.8); 2.8972 (1.1); 2.8862 (0.8); 2.8567 (1.3); 2.8465 (1.0); 2.8293 (0.8); 2.7991 (1.0); 2.7893 (1.0); 2.6745 (1.0); 2.6700 (1.4); 2.6655 (0.9); 2.5981 (1.2); 2.5913 (1.4); 2.5760 (1.5); 2.5590 (0.6); 2.5368 (2.0); 2.5235 (4.2); 2.5188 (6.2); 2.5101 (83.2); 2.5056 (178.8); 2.5010 (248.2); 2.4963 (172.2); 2.4918 (75.6); 2.4622 (0.9); 2.4403 (1.3); 2.4001 (1.6); 2.3780 (1.0); 2.3324 (1.3); 2.3278 (1.6); 2.3231 (1.2); 2.3015 (0.5); 2.2781 (1.0); 2.2648 (1.0); 2.2531 (1.4); 2.2410 (1.4); 2.2043 (1.7); 2.1921 (1.4); 2.1708 (1.2); 2.1402 (1.3); 2.1158 (1.1); 2.0962 (1.2); 2.0608 (1.1); 1.6470 (1.9); 1.6141 (2.2); 1.5103 (0.8); 1.3485 (0.5); 1.2147 (4.0); 1.1970 (7.8); 1.1943 (7.2); 1.1888 (3.8); 1.1820 (6.9); 1.1765 (12.8); 1.1711 (6.1); 1.1643 (11.9); 1.1588 (5.9); 1.1534 (2.9); 1.1466 (5.2); 0.0080 (1.4); -0.0002 (47.2); -0.0086 (1.2) I.1-305: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 10.4725 (1.2); 8.1108 (0.9); 8.1085 (1.0); 8.0899 (1.0); 8.0876 (1.0); 7.8869 (1.0); 7.8834 (1.1); 7.8670 (1.1); 7.8635 (1.1); 7.6090 (0.6); 7.6048 (0.6); 7.5905 (0.7); 7.5868 (0.8); 7.5842 (0.6); 7.5698 (0.6); 7.5657 (0.6); 7.2211 (0.8); 7.2181 (0.8); 7.2026 (1.0); 7.2013 (1.0); 7.1997 (1.0); 7.1985 (1.0); 7.1830 (0.8); 7.1800 (0.7); 7.1015 (7.5); 4.6827 (0.9); 4.6446 (1.0); 4.1027 (1.0); 4.0647 (0.9); 3.8249 (16.0); 3.8111 (0.5); 3.6473 (1.5); 2.8263 (0.6); 2.8150 (0.6); 2.7893 (0.8); 2.7780 (0.7); 2.5236 (0.6); 2.5189 (1.0); 2.5102 (14.4); 2.5056 (31.1); 2.5010 (43.5); 2.4964 (30.6); 2.4918 (14.3); 2.4767 (0.9); 2.4556 (0.7); 2.4254 (0.5); 2.2801 (0.6); 2.2667 (0.6); 2.2496 (8.1); 2.0732 (0.6); -0.0002 (5.1) I.1-306: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 9.9796 (1.2); 7.5544 (1.5); 7.5515 (1.9); 7.5468 (0.6); 7.5327 (2.1); 7.5301 (1.9); 7.3081 (1.7); 7.3032 (0.6); 7.2895 (2.2); 7.2871 (1.9); 7.2728 (0.6); 7.2683 (1.7); 7.1246 (16.0); 7.0552 (0.8); 7.0368 (1.3); 7.0183 (0.6); 4.6938 (1.0); 4.6558 (1.1); 4.0696 (1.1); 4.0316 (1.0); 3.8135 (0.6); 3.3228 (17.6); 2.7593 (0.7); 2.7482 (0.7); 2.7233 (0.9); 2.7122 (0.8); 2.5102 (6.6); 2.5056 (14.3); 2.5010 (20.0); 2.4963 (14.0); 2.4917 (6.2); 2.3892 (1.0); 2.3728 (0.6); 2.3671 (1.1); 2.3527 (0.9); 2.3309 (0.7); 2.2918 (0.6); 2.2811 (1.0); 2.2731 (9.7); 2.0730 (0.9); -0.0002 (2.5) I.1-307: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.2756 (1.9); 8.2707 (1.9); 8.2395 (0.6); 8.2338 (0.6); 7.6813 (1.2); 7.6750 (1.2); 7.6607 (1.5); 7.6545 (1.5); 7.5234 (0.8); 7.5038 (0.6); 7.4882 (2.4); 7.4869 (2.4); 7.4678 (2.0); 7.4664 (2.0); 7.1415 (1.2); 7.1212 (5.0); 7.1093 (5.6); 7.0886 (1.3); 7.0765 (1.2); 7.0414 (1.3); 7.0215 (0.6); 4.6772 (1.2); 4.6390 (1.7); 4.5249 (0.9); 4.5167 (0.8); 4.5074 (0.8); 4.4873 (2.3); 4.4519 (2.3); 4.4140 (0.8); 4.0595 (1.4); 4.0219 (1.6); 3.7925 (0.6); 3.7800 (0.7); 3.7701 (0.6); 3.7602 (0.6); 3.5480 (2.4); 2.8634 (16.0); 2.8351 (0.8); 2.8254 (0.8); 2.7940 (1.0); 2.7847 (0.9); 2.7549 (4.1); 2.5238 (1.0); 2.5191 (1.6); 2.5104 (22.7); 2.5058 (49.6); 2.5012 (69.8); 2.4966 (48.8); 2.4920 (22.6); 2.4744 (1.0); 2.4513 (1.1); 2.4294 (0.6); 2.4121 (0.7); 2.3939 (0.6); 2.3704 (0.6); 2.3282 (0.5); 2.2740 (10.3); 2.2594 (3.3); 2.2411 (1.0); 2.2285 (0.8); 2.1995 (0.5); 2.1876 (0.6); 2.1350 (0.6); 2.1229 (0.5); 2.1154 (0.6); 2.1037 (0.7); 1.6496 (0.5); 1.6416 (0.6); 1.6306 (0.5); 0.0080 (1.0); -0.0002 (33.4); -0.0085 (1.0) I.1-308: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.9138 (2.4); 8.8925 (2.4); 7.3672 (0.6); 7.3634 (0.7); 7.3441 (4.2); 7.3408 (4.6); 7.3370 (2.2); 7.3280 (5.4); 7.3254 (7.4); 7.3225 (8.7); 7.3199 (7.9); 7.3063 (6.4); 7.3041 (7.4); 7.2603 (3.8); 7.2533 (16.0); 7.2451 (5.4); 7.2348 (9.3); 7.2312 (7.2); 7.2263 (2.0); 7.2221 (1.2); 7.2180 (1.2); 7.2146 (0.6); 7.1875 (0.7); 7.1838 (0.8); 7.1749 (0.7); 7.1711 (0.9); 7.1676 (1.3); 7.1641 (1.4); 7.1548 (1.3); 7.1516 (1.4); 7.1476 (0.9); 7.1435 (0.9); 7.1346 (0.8); 7.1312 (0.8); 7.0655 (1.4); 7.0495 (1.9); 7.0301 (1.0); 6.1065 (3.0); 6.0853 (2.9); 4.7258 (2.1); 4.6859 (2.4); 4.2210 (2.6); 4.1813 (2.3); 3.8224 (0.8); 3.8119 (1.2); 3.8016 (1.5); 3.7917 (1.2); 3.7812 (0.9); 3.4995 (3.8); 3.1668 (1.2); 2.6716 (1.9); 2.6607 (1.9); 2.6369 (2.1); 2.6258 (1.9); 2.5232 (1.7); 2.5185 (2.5); 2.5099 (32.0); 2.5053 (69.1); 2.5007 (95.9); 2.4961 (67.1); 2.4915 (30.0); 2.3845 (2.3); 2.3627 (2.7); 2.3497 (1.8); 2.3391 (1.6); 2.3277 (2.4); 2.3187 (1.7); 2.2968 (1.2); 2.2678 (1.1); 2.2547 (1.3); 2.2438 (1.6); 2.2308 (1.6); 2.2130 (0.6); 2.2018 (0.8); 2.1891 (0.8); 2.1245 (0.6); 2.1049 (1.0); 2.0929 (0.8); 2.0854 (0.7); 2.0811 (0.9); 2.0732 (1.4); 2.0537 (0.7); 2.0494 (1.0); 1.7912 (0.5); 1.7789 (0.8); 1.7680 (1.1); 1.7579 (1.0); 1.7465 (1.0); 1.7364 (1.0); 1.7254 (0.6); 0.0080 (1.2); -0.0002 (40.1); -0.0086 (1.1) I.1-309: 1 H-NMR (400.1 MHz, CDCl3): δ= 7.5185 (0.4); 7.2603 (76.8); 7.2598 (81.3); 7.2462 (0.4); 7.1586 (1.4); 7.1440 (1.3); 7.1378 (8.3); 7.1285 (8.4); 7.1076 (1.5); 6.9958 (0.4); 5.3280 (0.8); 4.6982 (0.3); 4.6600 (2.1); 4.6224 (2.4); 4.2056 (2.3); 4.1934 (0.3); 4.1680 (2.0); 4.1308 (0.5); 4.1130 (0.5); 3.9876 (0.4); 3.9764 (0.7); 3.9673 (0.9); 3.9562 (1.5); 3.9450 (0.9); 3.9360 (0.8); 3.9246 (0.4); 2.6555 (0.5); 2.6475 (0.9); 2.6381 (1.2); 2.6297 (1.3); 2.6206 (1.0); 2.6121 (0.6); 2.5317 (0.4); 2.5128 (0.5); 2.4894 (1.2); 2.4681 (2.4); 2.4561 (1.5); 2.4469 (1.1); 2.4319 (1.8); 2.4202 (2.2); 2.4100 (1.1); 2.3996 (1.4); 2.3859 (1.3); 2.3812 (0.8); 2.3674 (0.5); 2.3569 (0.9); 2.3431 (0.8); 2.3295 (16.0); 2.3186 (2.4); 2.2677 (0.6); 2.2482 (0.9); 2.2436 (0.5); 2.2352 (0.6); 2.2288 (0.5); 2.2242 (0.7); 2.2158 (1.0); 2.2111 (0.6); 2.2049 (0.4); 2.1961 (0.5); 2.1915 (0.8); 2.1719 (0.4); 2.0805 (1.8); 2.0601 (1.8); 2.0435 (3.3); 2.0240 (1.5); 1.8274 (0.4); 1.8143 (0.6); 1.8034 (0.8); 1.7937 (0.8); 1.7807 (0.8); 1.7706 (0.8); 1.7600 (0.6); 1.7467 (0.4); 1.5517 (10.0); 1.2764 (0.6); 1.2585 (1.3); 1.2411 (0.6); 0.7667 (1.0); 0.7584 (1.0); 0.7508 (2.8); 0.7365 (2.2); 0.7334 (2.4); 0.7279 (1.1); 0.7214 (1.1); 0.4283 (0.9); 0.4240 (1.1); 0.4175 (2.8); 0.4087 (2.7); 0.4040 (2.0); 0.3944 (0.8); 0.0083 (0.9); 0.0000 (35.8) I.1-310: 1 H-NMR (400.1 MHz, d 6 -DMSO): δ= 12.2691 (1.0); 7.4362 (1.3); 7.4309 (1.4); 7.4221 (1.6); 7.4168 (1.5); 7.4112 (1.6); 7.4007 (6.2); 7.3952 (3.4); 7.3811 (6.4); 7.3742 (5.7); 7.3609 (3.1); 7.3549 (4.2); 7.3439 (1.8); 7.3338 (2.0); 7.1955 (1.6); 7.1903 (1.8); 7.1799 (3.1); 7.1745 (3.0); 7.1690 (3.0); 7.1638 (2.9); 7.1534 (1.5); 7.1480 (1.3); 5.0782 (0.8); 5.0605 (2.6); 5.0424 (2.7); 5.0249 (0.9); 5.0067 (0.8); 4.9887 (2.5); 4.9708 (2.6); 4.9530 (0.8); 4.0291 (0.5); 4.0203 (1.1); 4.0107 (1.3); 4.0049 (1.3); 4.0004 (1.6); 3.9970 (1.6); 3.9917 (1.3); 3.9869 (1.4); 3.9770 (1.3); 3.9679 (0.6); 3.7143 (0.6); 3.7056 (1.1); 3.6945 (1.1); 3.6898 (1.2); 3.6856 (1.5); 3.6815 (1.6); 3.6707 (1.2); 3.6618 (1.2); 3.6539 (0.6); 3.5507 (0.7); 3.4161 (0.4); 3.3841 (0.4); 3.3736 (0.4); 3.3191 (65.5); 3.2699 (1.2); 3.1688 (1.1); 2.6791 (0.4); 2.6747 (0.8); 2.6700 (1.1); 2.6655 (0.9); 2.6573 (2.3); 2.6485 (2.3); 2.6174 (3.1); 2.6085 (3.1); 2.5986 (0.8); 2.5940 (0.6); 2.5735 (0.4); 2.5235 (2.5); 2.5188 (3.7); 2.5100 (56.5); 2.5056 (123.5); 2.5010 (173.8); 2.4964 (128.1); 2.4919 (62.3); 2.4753 (3.6); 2.4520 (5.0); 2.4474 (2.8); 2.4308 (4.0); 2.4196 (4.7); 2.4110 (2.9); 2.3953 (3.8); 2.3797 (2.6); 2.3555 (2.6); 2.3371 (0.5); 2.3325 (0.9); 2.3279 (1.2); 2.3233 (0.9); 2.2678 (2.3); 2.2587 (2.4); 2.2276 (4.0); 2.2186 (4.1); 2.2108 (1.3); 2.2025 (2.0); 2.1971 (1.6); 2.1928 (2.1); 2.1858 (5.4); 2.1781 (5.0); 2.1684 (4.0); 2.1614 (2.9); 2.1528 (4.3); 2.1399 (5.2); 2.1307 (3.1); 2.1161 (4.8); 2.1001 (2.9); 2.0935 (1.1); 2.0890 (1.1); 2.0823 (1.8); 2.0763 (2.9); 2.0593 (1.2); 2.0377 (0.5); 1.7216 (0.9); 1.7121 (1.4); 1.7055 (2.4); 1.6973 (1.2); 1.6897 (2.7); 1.6839 (3.8); 1.6683 (1.8); 1.6603 (1.6); 1.6523 (1.8); 1.6426 (0.9); 1.5865 (16.0); 1.5684 (16.0); 1.5436 (14.8); 1.5256 (14.7) I.1-312: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.1436 (2.3); 7.1242 (7.0); 7.1038 (5.4); 7.0830 (2.3); 3.3907 (1.1); 3.3314 (1260.6); 3.2803 (4.0); 3.1676 (4.2); 2.7554 (2.3); 2.6746 (3.3); 2.6700 (4.8); 2.6655 (3.4); 2.5235 (9.0); 2.5188 (14.0); 2.5102 (259.8); 2.5056 (572.3); 2.5010 (802.6); 2.4965 (566.1); 2.4919 (258.8); 2.4550 (3.3); 2.4499 (3.4); 2.4128 (2.4); 2.3325 (3.9); 2.3278 (5.7); 2.3232 (4.2); 2.2749 (16.0); 2.0728 (3.5); 1.8865 (2.1); 1.6493 (1.2); 1.0877 (1.2); 1.0692 (2.2); 1.0514 (1.4); -0.0002 (9.4) I.1-314: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 10.6278 (0.8); 8.0424 (0.7); 7.2236 (1.9); 7.2226 (2.0); 7.2018 (2.1); 7.2007 (2.2); 7.1386 (1.1); 7.1185 (3.2); 7.0998 (3.6); 7.0794 (2.5); 7.0741 (1.5); 6.9990 (1.6); 6.9929 (1.6); 6.7205 (1.2); 6.7145 (1.1); 6.6988 (1.0); 6.6928 (1.0); 4.6611 (0.9); 4.6233 (1.0); 4.0014 (1.0); 3.9635 (0.9); 3.7458 (16.0); 3.4762 (7.2); 3.3174 (0.9); 3.3023 (1.0); 3.2841 (0.5); 2.7724 (0.9); 2.7542 (1.5); 2.7359 (0.8); 2.5188 (0.5); 2.5101 (9.0); 2.5055 (19.8); 2.5009 (27.4); 2.4963 (19.5); 2.4917 (8.4); 2.4727 (0.7); 2.4616 (0.7); 2.3265 (0.6); 2.2735 (7.2); 2.2362 (0.5); 2.2260 (0.6); 2.2122 (0.6); 2.1202 (0.7); 2.0976 (0.7); 2.0856 (0.6); 2.0727 (0.7); 2.0629 (0.6); -0.0002 (1.2) I.1-318: 1 H-NMR (400.1 MHz, d6-DMSO): δ= 11.4836 (1.4); 7.2489 (0.3); 7.2321 (0.3); 7.1991 (0.4); 7.1792 (0.4); 7.1314 (4.1); 7.1202 (4.3); 4.6747 (1.0); 4.6373 (1.2); 4.6032 (0.4); 4.4149 (0.3); 4.3513 (0.3); 4.3082 (0.3); 4.2870 (0.4); 4.2644 (0.4); 4.2499 (0.4); 4.2284 (0.4); 4.2148 (0.4); 4.1761 (0.4); 4.1732 (0.4); 4.1404 (0.5); 4.1281 (0.4); 4.1103 (0.4); 4.0872 (0.5); 4.0828 (0.5); 4.0689 (0.5); 4.0539 (0.5); 4.0104 (1.4); 3.9748 (1.3); 3.9426 (0.6); 3.9256 (0.6); 3.9098 (0.6); 3.8889 (0.6); 3.8618 (0.6); 3.8241 (0.6); 3.7866 (0.7); 3.7538 (0.8); 3.7078 (1.5); 3.6998 (1.4); 3.6480 (0.9); 3.5854 (1.0); 3.5828 (1.0); 3.5663 (1.0); 3.5352 (1.1); 3.4436 (1.3); 3.3391 (18.2); 3.2785 (1.2); 3.2364 (0.9); 3.2182 (0.9); 3.1982 (0.8); 3.1902 (0.9); 3.1703 (0.9); 3.1399 (0.9); 3.1315 (0.9); 3.0964 (1.0); 3.0809 (1.1); 3.0708 (1.0); 3.0671 (1.0); 3.0547 (1.0); 3.0504 (1.0); 3.0119 (1.2); 2.9768 (1.2); 2.9718 (1.2); 2.9397 (1.4); 2.8992 (1.5); 2.8906 (1.5); 2.8650 (1.7); 2.7710 (16.0); 2.7032 (2.7); 2.6750 (3.0); 2.5785 (3.0); 2.4997 (46.7); 2.4063 (1.3); 2.3781 (1.5); 2.3578 (2.0); 2.3354 (2.0); 2.2779 (6.6); 2.2245 (0.7); 2.1373 (0.4); 2.1212 (0.7); 2.0937 (0.8); 2.0686 (0.7); 1.7201 (0.7); 1.7097 (0.8); 1.6700 (0.5); 0.0274 (0.5) I.1-319: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.4865 (0.9); 8.4679 (1.5); 8.4490 (1.0); 7.2890 (0.8); 7.2703 (2.0); 7.2675 (1.9); 7.2530 (3.2); 7.2392 (0.6); 7.2327 (2.2); 7.2307 (2.3); 7.2142 (2.2); 7.2114 (2.3); 7.2006 (4.5); 7.1840 (2.3); 7.1713 (1.5); 7.1624 (4.6); 7.1581 (7.1); 7.1434 (1.3); 7.1320 (0.9); 7.1273 (0.8); 7.0623 (1.8); 7.0475 (1.4); 4.6617 (1.7); 4.6221 (1.9); 4.5089 (0.5); 4.4563 (0.6); 4.4479 (0.5); 4.4368 (0.5); 3.9971 (1.1); 3.9741 (1.1); 3.9585 (1.0); 3.9348 (1.0); 3.5991 (15.8); 3.5939 (16.0); 3.5716 (0.8); 3.5483 (0.7); 3.4108 (8.0); 3.0655 (0.5); 3.0520 (1.0); 3.0389 (0.6); 3.0311 (0.8); 3.0179 (1.4); 3.0047 (0.7); 2.8671 (1.1); 2.8429 (1.2); 2.8333 (0.9); 2.8092 (0.8); 2.6741 (0.6); 2.6695 (0.9); 2.6649 (0.6); 2.5229 (2.3); 2.5183 (3.6); 2.5096 (51.8); 2.5050 (112.3); 2.5004 (155.8); 2.4958 (109.0); 2.4912 (49.4); 2.4732 (1.4); 2.4682 (1.4); 2.4576 (1.2); 2.4495 (1.3); 2.4396 (0.9); 2.3319 (0.8); 2.3272 (1.0); 2.3227 (0.7); 2.3122 (0.8); 2.2914 (1.0); 2.2704 (1.5); 2.2482 (0.9); 2.2233 (0.8); 2.2051 (11.5); 2.2020 (12.2); 2.1699 (1.3); 2.1597 (1.1); 2.1432 (1.0); 2.1358 (0.9); 2.1087 (0.6); 2.0851 (1.1); 0.0080 (2.4); -0.0002 (80.7); -0.0086 (2.3) I.1-320: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.5024 (0.6); 8.4876 (0.7); 8.4829 (0.7); 8.4684 (0.6); 7.2706 (1.0); 7.2683 (1.0); 7.2532 (1.5); 7.2375 (0.7); 7.2336 (0.8); 7.2203 (1.9); 7.2149 (1.8); 7.2064 (3.0); 7.1934 (3.2); 7.1742 (2.9); 7.1069 (1.8); 7.0949 (1.8); 7.0868 (1.2); 7.0746 (1.2); 4.6414 (0.6); 4.6272 (0.6); 4.6031 (0.7); 4.5893 (0.6); 3.9586 (0.6); 3.9204 (0.6); 3.8827 (0.6); 3.8447 (0.6); 3.6013 (16.0); 3.4826 (1.8); 3.0304 (0.6); 3.0182 (0.5); 2.8693 (1.0); 2.8566 (0.6); 2.8445 (0.7); 2.8389 (0.8); 2.8347 (0.9); 2.5310 (0.5); 2.5186 (1.1); 2.5097 (13.6); 2.5052 (29.1); 2.5006 (40.4); 2.4960 (28.9); 2.4914 (13.0); 2.4738 (0.6); 2.1868 (0.6); 2.1760 (0.6); 2.1626 (0.6); 2.1304 (0.9); 2.1202 (0.6); 2.0960 (0.6); 1.1912 (8.7); 1.1874 (9.0); 1.1739 (8.7); 1.1701 (8.8); -0.0002 (14.5) I.1-321: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 9.7394 (0.5); 8.3515 (1.0); 7.1505 (2.5); 7.1299 (8.7); 7.1152 (11.1); 7.0945 (2.8); 4.7081 (0.9); 4.6707 (1.1); 4.6600 (2.0); 4.6217 (2.3); 4.3155 (0.8); 4.0303 (2.4); 4.0107 (1.1); 3.9921 (2.1); 3.9724 (1.0); 3.7278 (0.9); 3.7170 (1.1); 3.7073 (1.4); 3.6967 (1.2); 3.6857 (0.9); 3.1685 (0.9); 2.7695 (0.5); 2.7586 (0.5); 2.7316 (0.6); 2.7215 (0.6); 2.6700 (0.5); 2.6119 (27.4); 2.5646 (4.4); 2.5237 (1.2); 2.5190 (2.0); 2.5103 (35.9); 2.5057 (79.5); 2.5011 (111.6); 2.4965 (78.9); 2.4919 (36.1); 2.4654 (1.6); 2.4550 (1.8); 2.4305 (1.8); 2.4195 (1.7); 2.3993 (1.3); 2.3756 (1.9); 2.3650 (6.9); 2.3385 (2.0); 2.3277 (1.0); 2.3234 (1.0); 2.3154 (1.0); 2.2780 (16.0); 2.2608 (1.6); 2.2469 (1.4); 2.2274 (0.9); 2.2191 (0.8); 2.2054 (0.7); 2.0976 (0.6); 2.0879 (1.6); 2.0788 (1.0); 2.0731 (1.0); 2.0657 (2.2); 2.0531 (2.1); 2.0469 (1.3); 2.0301 (1.7); 1.7149 (0.6); 1.7045 (0.8); 1.6860 (0.8); 1.6726 (0.8); 1.6623 (0.7); -0.0002 (18.9); -0.0086 (0.6) I.1-322: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.9181 (1.7); 8.8964 (1.7); 7.3487 (1.8); 7.3424 (2.0); 7.3386 (1.4); 7.3280 (4.7); 7.3217 (4.1); 7.3120 (4.8); 7.3055 (4.1); 7.2645 (7.8); 7.2549 (8.1); 7.2467 (5.6); 7.2367 (5.3); 7.2281 (1.2); 7.2183 (0.8); 7.1463 (2.7); 7.1260 (6.3); 7.0943 (6.3); 7.0738 (2.8); 6.1132 (2.1); 6.0923 (2.0); 4.6655 (1.8); 4.6278 (2.0); 3.9849 (2.0); 3.9465 (1.7); 3.7375 (0.6); 3.7268 (0.8); 3.7161 (0.9); 3.7070 (0.9); 3.6959 (0.6); 3.3526 (1.0); 3.3183 (139.8); 3.1677 (0.8); 2.6742 (0.8); 2.6696 (1.1); 2.6651 (0.8); 2.6565 (1.2); 2.6451 (1.1); 2.6217 (1.3); 2.6104 (1.3); 2.5934 (1.2); 2.5739 (3.6); 2.5550 (4.0); 2.5355 (2.1); 2.5231 (1.8); 2.5184 (3.2); 2.5098 (61.4); 2.5052 (135.6); 2.5006 (189.8); 2.4960 (133.7); 2.4914 (60.6); 2.3531 (0.6); 2.3312 (2.2); 2.3228 (1.1); 2.3082 (2.0); 2.2952 (1.5); 2.2734 (1.2); 2.2602 (0.8); 2.2463 (1.0); 2.2358 (1.0); 2.2225 (1.0); 2.1941 (0.6); 2.0730 (0.8); 2.0326 (0.6); 2.0074 (0.6); 2.0004 (0.9); 1.9760 (0.7); 1.7313 (0.6); 1.7185 (0.7); 1.7077 (0.7); 1.6859 (0.6); 1.1728 (7.0); 1.1538 (16.0); 1.1348 (6.8); -0.0002 (15.8) I.1-323: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.1791 (3.6); 7.1587 (10.4); 7.1375 (7.8); 7.1219 (3.0); 7.1173 (3.2); 7.0997 (1.9); 7.0790 (0.8); 5.0635 (1.3); 5.0563 (1.3); 5.0497 (1.3); 4.7506 (1.3); 4.7120 (2.2); 4.6985 (1.2); 4.6727 (0.8); 4.6601 (1.6); 4.3056 (0.5); 4.2712 (0.5); 4.1686 (1.1); 4.1510 (1.8); 4.1334 (1.4); 4.1255 (1.4); 4.1142 (1.6); 4.1083 (2.8); 4.1058 (2.7); 4.0963 (4.3); 4.0905 (3.6); 4.0882 (3.5); 4.0785 (4.2); 4.0729 (1.0); 4.0608 (1.5); 4.0506 (2.3); 4.0099 (1.6); 3.9699 (0.7); 3.9627 (0.6); 3.7635 (0.6); 3.7524 (0.8); 3.7433 (1.1); 3.7330 (1.2); 3.7217 (1.3); 3.7101 (1.5); 3.7005 (1.4); 3.6909 (1.2); 3.6657 (1.4); 3.5718 (5.9); 3.1659 (2.5); 3.0075 (0.6); 2.9870 (0.5); 2.9621 (0.6); 2.9552 (0.6); 2.8547 (1.0); 2.8448 (0.7); 2.8146 (1.1); 2.8041 (1.1); 2.7924 (0.7); 2.7627 (0.8); 2.7534 (0.8); 2.6790 (0.5); 2.6743 (1.1); 2.6697 (1.6); 2.6651 (1.1); 2.6604 (0.5); 2.6033 (2.0); 2.5843 (6.3); 2.5654 (6.2); 2.5456 (3.0); 2.5401 (1.6); 2.5358 (0.7); 2.5231 (3.7); 2.5185 (6.3); 2.5098 (90.4); 2.5052 (196.0); 2.5006 (275.0); 2.4960 (194.0); 2.4914 (87.1); 2.4766 (2.7); 2.4725 (2.5); 2.4678 (2.0); 2.4632 (1.1); 2.4590 (0.8); 2.4359 (1.1); 2.4137 (1.8); 2.3909 (2.2); 2.3735 (1.7); 2.3514 (1.2); 2.3368 (0.9); 2.3320 (1.3); 2.3274 (1.7); 2.3227 (1.3); 2.3181 (0.9); 2.2693 (1.3); 2.2565 (1.3); 2.2450 (1.9); 2.2318 (1.7); 2.2147 (0.8); 2.2034 (1.1); 2.1907 (1.0); 2.1214 (1.2); 2.1028 (1.3); 2.0843 (2.0); 2.0730 (2.1); 2.0473 (1.4); 1.9086 (1.0); 1.6587 (0.6); 1.6380 (1.6); 1.6276 (1.8); 1.6166 (1.9); 1.6060 (1.8); 1.5962 (1.9); 1.5855 (1.8); 1.5654 (1.5); 1.5330 (1.3); 1.5094 (0.6); 1.4999 (0.7); 1.4869 (0.8); 1.2173 (3.4); 1.1995 (6.1); 1.1900 (6.0); 1.1817 (7.3); 1.1777 (7.5); 1.1722 (15.2); 1.1643 (10.1); 1.1589 (13.6); 1.1572 (13.9); 1.1543 (16.0); 1.1458 (4.7); 1.1397 (6.4); 1.1381 (6.7); 0.0080 (3.4); -0.0002 (123.4); -0.0085 (3.7); -0.0333 (0.8) I.1-324: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.2668 (1.7); 8.2466 (1.8); 7.1437 (1.8); 7.1231 (8.0); 7.1112 (8.3); 7.0904 (1.8); 4.6609 (1.9); 4.6225 (2.0); 4.2420 (0.6); 4.2272 (0.8); 4.2193 (0.8); 4.2073 (1.0); 4.1841 (0.7); 4.0555 (2.0); 4.0174 (1.8); 3.7200 (0.6); 3.7097 (0.9); 3.6991 (1.1); 3.6887 (0.9); 3.6786 (0.7); 3.3760 (0.8); 3.3562 (1.6); 3.3244 (311.6); 3.2739 (2.1); 3.1676 (0.8); 2.6746 (1.0); 2.6701 (1.3); 2.6655 (0.9); 2.5236 (3.9); 2.5188 (5.2); 2.5102 (79.8); 2.5056 (175.6); 2.5010 (245.7); 2.4963 (171.1); 2.4918 (77.6); 2.4551 (1.6); 2.4505 (1.8); 2.4460 (1.4); 2.3660 (0.6); 2.3472 (1.2); 2.3278 (2.4); 2.3232 (1.8); 2.3061 (0.9); 2.2760 (16.0); 2.2546 (1.1); 2.2440 (1.2); 2.2299 (1.2); 2.2149 (1.6); 2.2016 (0.7); 2.1935 (1.5); 2.1812 (1.2); 2.1592 (1.1); 2.0729 (0.8); 2.0329 (0.6); 2.0203 (0.6); 2.0079 (0.7); 2.0006 (0.9); 1.9763 (0.7); 1.7170 (0.6); 1.7064 (0.7); 1.6954 (0.7); 1.6746 (0.6); 1.6014 (0.7); 1.5845 (0.7); 1.5699 (0.5); 1.5099 (1.4); 1.4991 (1.7); 1.4849 (2.2); 1.4739 (1.3); 1.4629 (1.2); 0.8910 (9.1); 0.8746 (8.8); 0.8248 (9.0); 0.8085 (8.8); 0.0080 (1.0); -0.0002 (34.1); -0.0085 (1.0) I.1-325: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.4143 (3.5); 7.3966 (9.3); 7.3773 (7.7); 7.3360 (5.4); 7.3149 (4.4); 7.2941 (1.8); 7.2198 (10.3); 7.2165 (13.7); 7.1984 (10.2); 7.1280 (2.6); 7.1130 (2.5); 6.9106 (2.5); 4.5335 (2.1); 4.4938 (2.4); 4.1158 (2.5); 4.0738 (2.0); 3.8120 (2.3); 3.3795 (69.8); 3.1666 (4.9); 3.1037 (16.0); 2.6746 (1.9); 2.6700 (2.6); 2.6654 (1.8); 2.5546 (0.8); 2.5500 (1.0); 2.5404 (1.4); 2.5370 (0.7); 2.5234 (7.1); 2.5187 (11.0); 2.5101 (146.5); 2.5055 (316.7); 2.5009 (439.2); 2.4963 (307.5); 2.4917 (137.4); 2.4728 (2.3); 2.4679 (2.2); 2.4499 (0.8); 2.4273 (1.8); 2.3851 (2.0); 2.3808 (2.1); 2.3370 (1.2); 2.3323 (2.2); 2.3278 (2.8); 2.3231 (2.1); 2.2394 (3.8); 2.2185 (4.4); 2.2055 (3.8); 2.1769 (3.0); 2.1419 (2.2); 2.1213 (1.7); 2.0992 (1.8); 2.0733 (2.9); 2.0365 (1.2); 1.6575 (1.8); 0.0080 (3.2); -0.0002 (105.9); -0.0085 (3.0) I.1-326: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.0055 (5.1); 7.9960 (5.0); 7.3809 (2.0); 7.3771 (2.1); 7.3604 (4.2); 7.3565 (4.6); 7.3505 (2.3); 7.3407 (3.0); 7.3347 (4.5); 7.3306 (3.9); 7.3141 (2.4); 7.3103 (2.3); 7.2073 (2.5); 7.2034 (2.7); 7.1945 (2.8); 7.1906 (3.4); 7.1874 (4.7); 7.1836 (5.0); 7.1746 (4.6); 7.1710 (5.1); 7.1672 (3.0); 7.1630 (2.9); 7.1542 (2.4); 7.1506 (2.6); 7.0670 (4.7); 7.0509 (6.4); 7.0315 (3.4); 4.7189 (7.5); 4.6791 (8.7); 4.2216 (9.4); 4.1817 (8.0); 3.8117 (1.5); 3.8006 (3.1); 3.7903 (4.2); 3.7802 (5.8); 3.7701 (4.3); 3.7599 (3.1); 3.7488 (1.6); 3.4239 (15.9); 3.1669 (0.9); 2.6750 (0.9); 2.6703 (1.2); 2.6658 (0.8); 2.6005 (1.0); 2.5906 (2.8); 2.5809 (4.0); 2.5724 (6.2); 2.5626 (6.6); 2.5539 (4.0); 2.5444 (3.2); 2.5342 (1.8); 2.5238 (4.0); 2.5191 (5.6); 2.5104 (75.1); 2.5059 (162.0); 2.5012 (225.4); 2.4967 (158.0); 2.4921 (71.3); 2.4711 (0.7); 2.4571 (7.3); 2.4453 (7.2); 2.4220 (8.3); 2.4102 (7.9); 2.3899 (1.8); 2.3703 (2.4); 2.3673 (2.3); 2.3478 (5.5); 2.3281 (6.5); 2.3056 (4.4); 2.2827 (4.4); 2.2692 (5.3); 2.2587 (6.5); 2.2453 (6.2); 2.2411 (2.6); 2.2274 (2.1); 2.2168 (3.3); 2.2037 (3.2); 2.1445 (8.8); 2.1296 (4.7); 2.1234 (9.5); 2.1175 (3.8); 2.1095 (9.2); 2.0982 (5.1); 2.0936 (3.5); 2.0881 (7.9); 2.0787 (2.9); 2.0741 (3.9); 2.0548 (1.5); 1.7474 (2.1); 1.7347 (3.0); 1.7240 (4.2); 1.7138 (3.4); 1.7025 (3.4); 1.6921 (3.8); 1.6816 (2.2); 1.6684 (1.6); 0.6075 (5.0); 0.5954 (12.4); 0.5904 (16.0); 0.5782 (15.3); 0.5725 (13.3); 0.5608 (5.8); 0.5390 (0.7); 0.5209 (0.6); 0.3885 (0.6); 0.3789 (0.6); 0.3484 (5.5); 0.3373 (14.4); 0.3313 (12.8); 0.3272 (12.7); 0.3217 (12.6); 0.3107 (4.2); 0.0080 (2.9); -0.0002 (93.3); -0.0085 (2.8) I.1-327: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 7.9099 (0.9); 7.1438 (2.0); 7.1236 (7.3); 7.1086 (8.0); 7.1031 (1.5); 7.0880 (2.1); 4.6644 (2.0); 4.6265 (2.2); 4.0109 (2.3); 3.9730 (2.0); 3.7199 (0.7); 3.7088 (1.0); 3.6984 (1.1); 3.6888 (0.9); 3.6778 (0.8); 3.3241 (48.4); 3.0688 (0.8); 3.0549 (1.1); 3.0507 (2.7); 3.0369 (2.9); 3.0326 (2.9); 3.0189 (2.8); 3.0147 (1.1); 3.0008 (0.9); 2.5229 (1.0); 2.5182 (1.4); 2.5095 (20.8); 2.5050 (45.0); 2.5003 (62.6); 2.4957 (43.2); 2.4911 (19.3); 2.4834 (1.9); 2.4719 (1.6); 2.4486 (1.8); 2.4374 (1.7); 2.3424 (1.2); 2.3227 (1.2); 2.3001 (0.9); 2.2758 (16.0); 2.2651 (1.3); 2.2512 (1.2); 2.2408 (1.4); 2.2271 (1.4); 2.2093 (0.6); 2.1989 (0.7); 2.1853 (0.7); 2.0985 (1.8); 2.0761 (1.8); 2.0711 (0.6); 2.0640 (1.6); 2.0488 (0.9); 2.0416 (1.6); 2.0363 (0.7); 2.0298 (0.5); 2.0247 (0.7); 2.0172 (1.0); 2.0123 (0.6); 1.9979 (0.6); 1.9930 (0.8); 1.7022 (0.6); 1.6913 (0.8); 1.6807 (0.7); 1.6695 (0.6); 1.6592 (0.7); 1.0000 (7.3); 0.9820 (15.7); 0.9639 (7.0) I.1-328: 1 H-NMR (400.1 MHz, d6-DMSO): δ= 7.8524 (0.8); 7.8419 (0.8); 7.6457 (2.1); 7.1439 (1.9); 7.1233 (6.7); 7.1069 (7.3); 7.0864 (2.1); 7.0155 (5.2); 4.6677 (1.9); 4.6298 (2.1); 4.0010 (2.2); 3.9631 (2.0); 3.7275 (0.4); 3.7167 (0.8); 3.7057 (1.0); 3.6953 (1.2); 3.6855 (1.1); 3.6746 (0.9); 3.6638 (0.6); 3.3479 (3.8); 3.1713 (0.6); 2.5497 (9.8); 2.5382 (9.9); 2.5243 (0.5); 2.5189 (0.6); 2.5105 (8.4); 2.5061 (18.0); 2.5016 (25.5); 2.4971 (19.8); 2.4926 (9.5); 2.4857 (2.1); 2.4616 (1.7); 2.4506 (1.5); 2.3831 (0.4); 2.3644 (0.6); 2.3599 (0.5); 2.3411 (1.1); 2.3227 (1.0); 2.3186 (1.0); 2.2991 (0.9); 2.2756 (16.0); 2.2639 (1.5); 2.2564 (0.5); 2.2498 (1.2); 2.2396 (1.4); 2.2258 (1.3); 2.2080 (0.5); 2.1976 (0.7); 2.1840 (0.6); 2.1117 (1.6); 2.0892 (1.6); 2.0768 (1.4); 2.0690 (0.7); 2.0543 (1.4); 2.0495 (0.9); 2.0449 (0.5); 2.0367 (0.6); 2.0301 (0.5); 2.0252 (0.7); 2.0176 (0.9); 2.0129 (0.6); 2.0062 (0.4); 1.9982 (0.5); 1.9934 (0.7); 1.9742 (0.3); 1.9095 (0.4); 1.7078 (0.4); 1.6946 (0.6); 1.6837 (0.9); 1.6736 (0.7); 1.6620 (0.7); 1.6517 (0.8); 1.6409 (0.5); 1.6276 (0.3) I.1-329: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 9.6096 (3.8); 8.6453 (3.5); 8.6295 (4.5); 8.6128 (0.8); 8.2597 (1.8); 8.2360 (2.5); 8.2172 (2.0); 7.8831 (1.4); 7.8676 (2.4); 7.8325 (2.7); 7.8125 (2.7); 7.7945 (1.4); 7.1251 (4.2); 7.1192 (2.4); 7.1111 (2.4); 7.1050 (6.7); 7.0816 (7.4); 7.0611 (2.7); 4.8193 (0.6); 4.8045 (0.7); 4.7811 (1.6); 4.7666 (1.6); 4.7442 (1.6); 4.7305 (1.7); 4.7062 (0.7); 4.6924 (0.7); 4.6421 (2.3); 4.6257 (0.5); 4.6041 (2.5); 4.2998 (0.5); 4.1116 (0.6); 4.0739 (0.6); 4.0490 (0.5); 3.9870 (2.4); 3.9490 (2.1); 3.7538 (0.8); 3.7428 (1.0); 3.7318 (1.1); 3.7223 (1.0); 3.7116 (0.8); 3.5971 (0.5); 3.5798 (0.6); 3.1667 (2.7); 2.7678 (3.4); 2.7580 (2.9); 2.6705 (0.7); 2.6088 (1.2); 2.5982 (1.2); 2.5739 (1.4); 2.5632 (1.4); 2.5240 (1.3); 2.5193 (1.9); 2.5107 (33.4); 2.5060 (74.0); 2.5014 (103.9); 2.4968 (73.2); 2.4922 (32.8); 2.3375 (0.7); 2.3330 (0.6); 2.3283 (0.7); 2.3236 (0.7); 2.3184 (1.3); 2.2988 (1.1); 2.2947 (1.2); 2.2687 (16.0); 2.2552 (1.3); 2.2410 (1.5); 2.2367 (2.0); 2.2311 (1.6); 2.2143 (2.3); 2.2017 (1.6); 2.1890 (0.8); 2.1793 (1.6); 2.0736 (0.9); 2.0532 (0.8); 2.0488 (0.5); 2.0406 (0.6); 2.0339 (0.5); 2.0289 (0.7); 2.0217 (0.9); 2.0168 (0.6); 2.0021 (0.6); 1.9973 (0.7); 1.7126 (0.7); 1.7018 (1.0); 1.6913 (0.9); 1.6803 (0.9); 1.6696 (0.9); 1.6595 (0.6); 1.0699 (0.7); 1.0520 (1.6); 1.0339 (0.7); 1.0267 (0.6); 1.0093 (1.4); 0.9916 (0.6); 0.0080 (2.0); 0.0064 (0.6); 0.0056 (0.7); 0.0048 (0.8); 0.0039 (1.0); 0.0022 (2.8); -0.0002 (67.1); -0.0051 (0.9); -0.0059 (0.7); -0.0067 (0.6); -0.0085 (1.9) I.1-330: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.9359 (3.3); 7.9214 (6.3); 7.9072 (3.3); 7.3843 (1.9); 7.3803 (2.1); 7.3636 (4.3); 7.3596 (4.6); 7.3538 (2.4); 7.3438 (3.0); 7.3377 (4.6); 7.3337 (4.0); 7.3175 (2.4); 7.3137 (2.3); 7.2093 (2.5); 7.2054 (2.6); 7.1966 (2.6); 7.1925 (3.3); 7.1890 (4.7); 7.1856 (5.0); 7.1765 (4.6); 7.1731 (5.1); 7.1691 (3.1); 7.1651 (3.0); 7.1562 (2.5); 7.1527 (2.7); 7.0727 (4.8); 7.0566 (6.5); 7.0372 (3.5); 4.7347 (7.5); 4.6948 (8.7); 4.2353 (9.3); 4.1954 (8.1); 3.8113 (3.1); 3.8002 (4.9); 3.7899 (6.5); 3.7798 (8.0); 3.7699 (6.8); 3.7596 (5.6); 3.7485 (3.8); 2.9174 (1.2); 2.9024 (1.8); 2.8849 (6.1); 2.8674 (11.6); 2.8523 (12.0); 2.8353 (5.9); 2.8174 (1.8); 2.8025 (1.3); 2.6770 (0.7); 2.6721 (1.0); 2.6674 (0.8); 2.5221 (7.9); 2.5121 (64.4); 2.5076 (133.3); 2.5030 (184.6); 2.4984 (130.0); 2.4938 (58.7); 2.4883 (11.4); 2.4762 (8.2); 2.4566 (0.9); 2.4004 (2.1); 2.3810 (2.4); 2.3585 (5.3); 2.3390 (5.4); 2.3355 (5.2); 2.3250 (1.4); 2.3162 (4.2); 2.2899 (4.0); 2.2764 (4.9); 2.2659 (6.0); 2.2525 (5.9); 2.2346 (2.2); 2.2240 (3.2); 2.2117 (9.7); 2.1907 (7.7); 2.1773 (6.5); 2.1559 (6.4); 2.1440 (2.2); 2.1245 (3.8); 2.1124 (2.8); 2.1052 (2.4); 2.1006 (3.5); 2.0931 (4.5); 2.0886 (2.9); 2.0813 (1.7); 2.0734 (2.7); 2.0689 (3.5); 2.0496 (1.5); 1.7686 (2.0); 1.7558 (2.8); 1.7451 (4.0); 1.7346 (3.4); 1.7237 (3.4); 1.7132 (3.6); 1.7027 (2.3); 1.6895 (2.0); 1.6558 (5.3); 1.6330 (16.0); 1.6060 (11.1); 1.3506 (1.7); 1.3411 (2.0); 1.3313 (2.5); 1.3235 (3.0); 1.3154 (2.6); 1.3045 (2.2); 1.2963 (2.0); 1.2783 (0.9); 1.1972 (1.3); 1.1666 (4.1); 1.1350 (8.7); 1.1196 (6.6); 1.1091 (6.2); 1.0787 (1.7); 1.0489 (0.6); 0.8691 (2.7); 0.8415 (5.9); 0.8164 (4.9); 0.7889 (1.7); 0.7801 (1.8); 0.0080 (1.0); -0.0002 (37.0); -0.0086 (1.1) I.1-331: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 12.7492 (0.6); 8.4977 (1.2); 8.4764 (1.2); 8.3071 (1.5); 8.2884 (1.6); 8.1752 (1.6); 8.1533 (2.0); 8.1346 (1.2); 7.2623 (1.5); 7.2450 (4.7); 7.2410 (5.0); 7.2324 (12.1); 7.2264 (9.4); 7.2210 (8.2); 7.2057 (8.6); 7.1919 (7.2); 7.1725 (5.5); 7.1592 (8.4); 7.1560 (8.7); 7.1484 (5.0); 7.1410 (6.9); 7.1378 (6.5); 7.1300 (3.6); 7.1220 (1.7); 7.1108 (1.6); 7.0980 (3.0); 7.0813 (2.1); 7.0357 (2.3); 7.0206 (1.9); 4.6177 (3.0); 4.5783 (3.1); 4.5388 (0.8); 4.5212 (0.7); 4.4587 (0.9); 4.4466 (1.0); 4.4386 (1.1); 4.4270 (1.0); 4.4056 (0.6); 3.9611 (1.3); 3.9337 (1.8); 3.9225 (1.2); 3.8931 (1.5); 3.5973 (0.6); 3.5532 (3.0); 3.5374 (2.2); 3.3639 (85.4); 3.1673 (4.3); 3.0967 (1.3); 3.0759 (1.5); 3.0538 (1.3); 3.0408 (1.2); 2.9863 (0.9); 2.9620 (1.1); 2.9513 (1.0); 2.9423 (1.2); 2.9202 (1.2); 2.9079 (0.8); 2.8854 (0.8); 2.8490 (0.8); 2.8242 (0.8); 2.7906 (0.6); 2.6743 (4.1); 2.6696 (6.2); 2.6651 (5.0); 2.6605 (2.5); 2.6316 (1.3); 2.6052 (1.2); 2.5498 (2.2); 2.5451 (2.9); 2.5399 (3.6); 2.5350 (2.8); 2.5300 (2.5); 2.5231 (13.3); 2.5184 (21.2); 2.5097 (309.4); 2.5052 (669.1); 2.5006 (935.7); 2.4960 (657.9); 2.4914 (295.3); 2.4634 (1.8); 2.4587 (0.8); 2.4495 (0.9); 2.4450 (1.0); 2.4182 (2.3); 2.4077 (2.2); 2.3841 (2.9); 2.3742 (2.4); 2.3566 (1.3); 2.3367 (2.2); 2.3320 (4.3); 2.3273 (5.8); 2.3227 (4.3); 2.3183 (2.1); 2.2839 (1.6); 2.2598 (1.3); 2.2396 (1.1); 2.2193 (2.8); 2.1922 (16.0); 2.1831 (12.6); 2.1592 (1.4); 2.1370 (1.7); 2.1230 (1.4); 2.1119 (1.4); 2.0946 (1.6); 2.0857 (1.9); 2.0730 (2.3); 2.0618 (1.8); 2.0522 (1.4); 2.0284 (1.2); 1.7478 (0.9); 1.7244 (0.7); 1.6381 (0.6); 1.5491 (0.8); 1.2439 (0.7); 0.1462 (1.2); 0.0080 (10.5); -0.0002 (385.4); -0.0086 (11.6); -0.0332 (1.4); - 0.1497 (1.2) I.1-332: 1 H-NMR (400.0 MHz, CDCl3): δ= 7.2619 (25.2); 7.1191 (2.5); 7.1134 (29.1); 7.1062 (2.2); 7.0978 (2.6); 7.0901 (1.0); 7.0844 (2.3); 7.0030 (2.8); 6.9976 (0.9); 6.9866 (0.8); 6.9813 (4.7); 6.9758 (0.8); 6.9649 (0.7); 6.9596 (1.9); 5.3536 (0.6); 5.2980 (1.0); 4.7087 (1.8); 4.6712 (2.0); 4.1166 (1.8); 4.0791 (1.6); 3.9393 (0.6); 3.9292 (0.7); 3.9188 (1.1); 3.9084 (0.7); 3.8983 (0.6); 3.4713 (0.8); 3.4532 (1.3); 3.4427 (0.6); 3.4381 (1.2); 3.4253 (1.2); 3.4205 (0.6); 3.4105 (1.2); 3.3930 (0.7); 2.7523 (1.8); 2.7346 (3.6); 2.7170 (1.7); 2.4898 (1.4); 2.4784 (1.3); 2.4642 (0.9); 2.4539 (1.5); 2.4423 (2.2); 2.4216 (0.8); 2.4144 (0.9); 2.4001 (1.0); 2.3902 (1.1); 2.3761 (1.2); 2.3474 (0.6); 2.3330 (0.8); 2.3241 (16.0); 2.2019 (0.7); 2.1888 (0.5); 2.1779 (0.6); 2.1694 (0.8); 2.1647 (0.6); 2.1452 (0.7); 2.0716 (1.5); 2.0504 (1.5); 2.0356 (1.3); 2.0144 (1.3); 1.7359 (0.6); 1.7263 (0.6); 1.7130 (0.6); 1.7029 (0.5); -0.0002 (7.5) I.1-333: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.9199 (1.7); 8.8986 (1.8); 7.3478 (2.0); 7.3425 (2.3); 7.3380 (1.4); 7.3269 (5.3); 7.3245 (4.2); 7.3216 (4.5); 7.3112 (5.0); 7.3055 (4.7); 7.2640 (8.3); 7.2544 (8.8); 7.2461 (5.9); 7.2363 (5.6); 7.2276 (1.3); 7.2219 (0.7); 7.2181 (0.9); 7.2054 (1.3); 7.1865 (3.1); 7.1677 (2.0); 7.0643 (1.8); 7.0454 (1.4); 6.9735 (3.2); 6.9508 (1.4); 6.1123 (2.2); 6.0911 (2.2); 4.6660 (1.9); 4.6276 (2.1); 3.9922 (2.1); 3.9538 (1.9); 3.7536 (0.6); 3.7431 (0.9); 3.7328 (1.0); 3.7227 (0.9); 3.7117 (0.6); 3.3152 (48.3); 2.6741 (0.6); 2.6694 (0.8); 2.6649 (0.6); 2.6531 (1.2); 2.6421 (1.2); 2.6185 (1.5); 2.6075 (1.4); 2.5308 (0.6); 2.5229 (2.3); 2.5182 (3.4); 2.5095 (46.1); 2.5050 (99.7); 2.5004 (139.2); 2.4958 (97.8); 2.4912 (43.8); 2.4673 (0.5); 2.3609 (0.5); 2.3416 (1.2); 2.3322 (2.1); 2.3272 (1.3); 2.3225 (1.7); 2.3104 (1.6); 2.2982 (2.0); 2.2754 (2.3); 2.2649 (16.0); 2.2509 (1.3); 2.2373 (1.2); 2.2089 (0.6); 2.1957 (0.6); 2.0729 (0.8); 2.0470 (0.7); 2.0346 (0.5); 2.0230 (0.7); 2.0152 (0.9); 1.9913 (0.7); 1.7403 (0.6); 1.7296 (0.8); 1.7196 (0.7); 1.7079 (0.7); 1.6978 (0.7); 0.0080 (1.9); -0.0002 (62.8); -0.0085 (1.8) I.1-334: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 7.4143 (3.5); 7.3966 (9.3); 7.3774 (7.7); 7.3357 (5.3); 7.3144 (4.4); 7.2936 (1.8); 7.2198 (10.2); 7.2166 (13.7); 7.1986 (10.3); 7.1265 (2.6); 7.1137 (2.5); 6.9103 (2.5); 4.5349 (2.1); 4.4944 (2.4); 4.1148 (2.5); 4.0751 (2.1); 3.8108 (2.4); 3.5617 (9.8); 3.1666 (2.1); 3.1039 (16.0); 2.6794 (0.6); 2.6747 (1.3); 2.6701 (1.8); 2.6655 (1.3); 2.6609 (0.6); 2.5512 (0.6); 2.5404 (1.0); 2.5236 (4.8); 2.5189 (7.4); 2.5102 (101.8); 2.5057 (220.3); 2.5011 (306.7); 2.4965 (214.8); 2.4919 (96.8); 2.4243 (1.8); 2.3894 (2.1); 2.3372 (0.9); 2.3325 (1.6); 2.3279 (2.1); 2.3233 (1.6); 2.2399 (3.8); 2.2185 (4.4); 2.2049 (3.8); 2.1774 (2.9); 2.1419 (2.2); 2.1229 (1.7); 2.0992 (1.8); 2.0735 (2.1); 2.0586 (1.4); 2.0369 (1.2); 1.6579 (1.8); 0.0080 (4.3); - 0.0002 (139.5); -0.0086 (4.0) I.1-337: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 7.3557 (0.7); 7.3346 (0.8); 7.2064 (0.5); 7.1867 (0.9); 7.1741 (0.8); 7.1701 (0.6); 7.0964 (0.6); 7.0807 (0.8); 4.7602 (0.8); 4.7216 (1.0); 4.7007 (0.5); 4.2677 (1.1); 4.2288 (1.0); 4.2046 (2.5); 4.0381 (3.8); 4.0344 (3.7); 3.8314 (0.6); 3.8214 (0.7); 3.8116 (0.7); 3.8014 (0.6); 3.6734 (7.6); 3.6199 (16.0); 3.3789 (32.3); 3.1663 (1.6); 2.9682 (14.8); 2.8497 (0.6); 2.8394 (0.6); 2.8092 (0.9); 2.7989 (0.8); 2.7689 (5.6); 2.6791 (0.5); 2.6744 (1.0); 2.6699 (1.3); 2.6652 (0.9); 2.5693 (1.0); 2.5469 (1.5); 2.5401 (1.2); 2.5344 (0.9); 2.5290 (1.4); 2.5233 (3.0); 2.5186 (4.7); 2.5099 (69.4); 2.5054 (150.9); 2.5007 (209.7); 2.4961 (147.6); 2.4916 (66.4); 2.4326 (0.6); 2.4082 (0.8); 2.3322 (1.0); 2.3275 (1.3); 2.3230 (1.0); 2.2558 (0.5); 2.2431 (0.8); 2.2318 (0.7); 2.2018 (0.6); 2.1947 (1.2); 2.1795 (0.6); 2.1478 (0.7); 1.6716 (0.5); 0.0080 (1.5); -0.0002 (51.2); -0.0086 (1.5) I.1-338: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.4209 (1.1); 7.4031 (2.7); 7.3842 (2.3); 7.3583 (0.9); 7.3409 (0.8); 7.1848 (3.9); 7.1811 (5.5); 7.1761 (1.5); 7.1636 (4.0); 7.1541 (0.6); 7.1296 (2.6); 7.1104 (3.1); 6.9988 (2.0); 6.9811 (1.5); 4.4267 (0.7); 4.3888 (0.8); 3.9487 (1.2); 3.9107 (1.2); 3.7862 (0.8); 3.7760 (1.0); 3.7662 (1.1); 3.7563 (0.9); 3.7463 (0.7); 3.1663 (0.7); 3.1072 (5.9); 2.6107 (1.5); 2.5917 (4.9); 2.5727 (5.0); 2.5537 (1.8); 2.5442 (0.5); 2.5384 (0.6); 2.5336 (0.8); 2.5235 (1.4); 2.5188 (2.0); 2.5101 (23.7); 2.5056 (50.5); 2.5010 (70.0); 2.4964 (48.9); 2.4918 (21.6); 2.4392 (0.6); 2.4104 (0.6); 2.4055 (0.7); 2.4008 (0.7); 2.2136 (1.2); 2.1996 (1.3); 2.1852 (1.0); 2.1063 (0.6); 2.0858 (0.6); 2.0734 (0.9); 2.0546 (0.6); 2.0031 (0.5); 1.6010 (0.5); 1.1927 (7.3); 1.1737 (16.0); 1.1547 (7.1); 0.0080 (1.2); -0.0002 (39.8); -0.0085 (1.1) I.1-339: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.0320 (1.0); 7.1438 (1.9); 7.1236 (7.4); 7.1095 (8.2); 7.0889 (2.0); 4.6690 (2.0); 4.6312 (2.2); 4.0083 (2.2); 3.9701 (2.0); 3.7116 (0.6); 3.7010 (0.9); 3.6907 (1.1); 3.6806 (0.9); 3.6696 (0.7); 3.3116 (121.2); 3.2917 (5.4); 3.2606 (0.5); 3.2248 (38.3); 3.2048 (1.3); 3.2020 (1.3); 3.1916 (2.6); 3.1879 (2.5); 3.1782 (2.3); 3.1731 (1.9); 3.1682 (1.2); 3.1646 (0.9); 3.1585 (0.8); 2.6741 (0.6); 2.6695 (0.8); 2.6648 (0.6); 2.5230 (1.8); 2.5183 (2.6); 2.5096 (47.1); 2.5050 (101.4); 2.5004 (141.9); 2.4958 (100.0); 2.4912 (44.6); 2.4735 (2.2); 2.4623 (1.8); 2.3656 (0.6); 2.3461 (1.2); 2.3272 (1.8); 2.3229 (1.5); 2.3040 (0.9); 2.2758 (16.0); 2.2604 (1.0); 2.2470 (1.2); 2.2363 (1.3); 2.2228 (1.3); 2.2053 (0.6); 2.1944 (0.7); 2.1810 (0.7); 2.1501 (1.7); 2.1278 (1.7); 2.1156 (1.6); 2.0933 (1.4); 2.0716 (0.7); 2.0403 (0.8); 2.0277 (0.6); 2.0207 (0.5); 2.0160 (0.7); 2.0088 (0.9); 1.9843 (0.8); 1.7100 (0.6); 1.6993 (0.8); 1.6882 (0.7); 1.6765 (0.7); 1.6671 (0.7); -0.0002 (0.6) I.1-340: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 7.3790 (1.0); 7.3587 (2.4); 7.3373 (2.4); 7.3133 (1.2); 7.2083 (1.2); 7.1881 (2.4); 7.1758 (2.3); 7.1555 (1.2); 7.0974 (1.4); 7.0810 (2.4); 7.0613 (1.8); 5.0604 (2.1); 4.7896 (1.6); 4.7776 (1.3); 4.7532 (3.2); 4.7154 (2.2); 4.2889 (1.8); 4.2645 (2.1); 4.2490 (1.5); 4.2378 (1.1); 4.2237 (1.8); 4.1984 (0.9); 4.1817 (0.8); 4.1674 (1.5); 4.1501 (2.4); 4.1302 (2.6); 4.1231 (2.2); 4.1178 (1.8); 4.1124 (4.6); 4.1100 (4.0); 4.1052 (5.8); 4.0945 (3.8); 4.0922 (3.6); 4.0875 (5.7); 4.0766 (1.2); 4.0698 (1.8); 3.8478 (1.2); 3.8370 (1.0); 3.8262 (1.0); 3.8149 (1.0); 3.8028 (1.0); 3.7943 (1.0); 3.7835 (1.2); 3.7373 (1.3); 3.7079 (0.8); 3.5386 (9.0); 3.1670 (1.4); 3.0621 (0.6); 3.0306 (0.9); 3.0202 (1.0); 3.0122 (1.0); 2.9884 (0.5); 2.8968 (1.2); 2.8868 (1.0); 2.8572 (1.5); 2.8464 (1.2); 2.8397 (1.0); 2.8291 (0.9); 2.7991 (1.2); 2.7893 (1.1); 2.6749 (0.8); 2.6704 (1.1); 2.6658 (0.8); 2.5986 (1.3); 2.5909 (1.7); 2.5767 (1.9); 2.5589 (0.8); 2.5367 (1.6); 2.5237 (3.4); 2.5190 (5.0); 2.5103 (68.7); 2.5057 (148.7); 2.5011 (207.4); 2.4965 (144.5); 2.4919 (63.9); 2.4622 (1.5); 2.4540 (0.5); 2.4408 (1.9); 2.4316 (1.4); 2.4177 (1.5); 2.4002 (2.0); 2.3780 (1.4); 2.3326 (1.3); 2.3280 (1.4); 2.3234 (1.3); 2.3013 (0.7); 2.2778 (1.3); 2.2653 (1.3); 2.2533 (1.8); 2.2411 (1.8); 2.2331 (1.4); 2.2120 (1.7); 2.2045 (2.0); 2.1926 (1.7); 2.1706 (1.6); 2.1607 (1.5); 2.1408 (1.6); 2.1173 (1.4); 2.0967 (1.5); 2.0629 (1.4); 1.7127 (0.6); 1.6878 (1.3); 1.6471 (2.3); 1.6150 (2.7); 1.5438 (0.9); 1.5288 (0.9); 1.5101 (0.9); 1.4921 (0.9); 1.3803 (0.5); 1.3487 (0.7); 1.2852 (0.6); 1.2149 (5.0); 1.1971 (9.6); 1.1945 (9.0); 1.1891 (4.7); 1.1822 (8.6); 1.1794 (6.6); 1.1767 (16.0); 1.1713 (7.6); 1.1645 (15.0); 1.1589 (7.6); 1.1536 (3.6); 1.1467 (6.5); 0.0080 (2.5); -0.0002 (80.2); -0.0086 (2.3) I.1-341: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.1804 (1.6); 7.1723 (5.2); 7.1678 (5.4); 7.1622 (2.6); 7.1547 (1.7); 7.1427 (1.2); 7.1037 (1.2); 7.0901 (1.0); 4.6999 (0.6); 4.6894 (1.2); 4.6610 (0.6); 4.6496 (1.3); 4.0858 (1.2); 4.0455 (1.1); 3.7002 (0.5); 3.6882 (0.7); 3.6777 (0.6); 3.6680 (0.6); 3.5945 (0.7); 3.5374 (16.0); 3.4021 (20.2); 3.2054 (0.8); 3.1879 (1.0); 3.1670 (1.0); 2.7499 (0.8); 2.7401 (0.8); 2.7259 (0.5); 2.7103 (1.0); 2.7005 (1.0); 2.6791 (0.7); 2.6744 (1.1); 2.6697 (1.5); 2.6651 (1.1); 2.5544 (0.5); 2.5498 (1.2); 2.5453 (1.6); 2.5400 (1.9); 2.5353 (1.4); 2.5301 (1.0); 2.5232 (4.0); 2.5185 (6.3); 2.5098 (83.7); 2.5052 (180.3); 2.5006 (251.0); 2.4960 (176.6); 2.4915 (80.0); 2.4703 (1.8); 2.4531 (0.7); 2.4445 (0.6); 2.4306 (1.6); 2.4137 (0.8); 2.3903 (0.8); 2.3761 (0.6); 2.3322 (1.5); 2.3275 (1.6); 2.3228 (1.2); 2.3088 (0.6); 2.2974 (0.6); 2.2843 (1.0); 2.2727 (1.0); 2.2670 (0.6); 2.2599 (0.7); 2.2469 (0.9); 2.2427 (0.9); 2.2317 (2.6); 2.2193 (13.2); 2.1913 (0.6); 2.1599 (0.8); 2.1353 (0.5); 1.7192 (0.5); 1.7097 (0.5); 1.0178 (0.7); 0.9998 (1.7); 0.9819 (0.7); 0.9667 (0.8); 0.9491 (1.9); 0.9313 (0.9); 0.8833 (1.3); 0.8739 (1.1); 0.8669 (1.4); 0.8577 (0.9); 0.8342 (0.9); 0.8281 (1.0); 0.8181 (1.4); 0.8079 (1.0); 0.8022 (0.8); 0.7919 (0.7); 0.0080 (1.3); -0.0002 (47.9); -0.0085 (1.4) I.1-342: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.0995 (1.0); 7.1450 (1.8); 7.1247 (7.6); 7.1120 (8.4); 7.0913 (1.8); 5.8113 (0.5); 5.7980 (1.2); 5.7852 (1.0); 5.7723 (1.3); 5.7683 (0.7); 5.7590 (0.6); 5.7550 (1.4); 5.7421 (1.1); 5.7293 (1.4); 5.7160 (0.6); 5.1332 (0.7); 5.1288 (2.2); 5.1244 (2.3); 5.1199 (0.8); 5.0902 (0.6); 5.0857 (1.9); 5.0813 (2.0); 5.0770 (0.7); 5.0631 (0.8); 5.0591 (2.3); 5.0549 (2.1); 5.0509 (0.7); 5.0374 (0.8); 5.0334 (2.1); 5.0292 (2.0); 5.0253 (0.7); 4.6760 (2.0); 4.6379 (2.2); 4.0133 (2.3); 3.9753 (2.0); 3.7254 (0.7); 3.7144 (1.0); 3.7041 (1.0); 3.6938 (1.0); 3.6831 (2.2); 3.6697 (2.9); 3.6560 (1.5); 3.6532 (1.4); 3.3111 (79.1); 3.1683 (0.6); 2.6693 (0.5); 2.5493 (1.5); 2.5383 (1.7); 2.5227 (1.4); 2.5094 (30.7); 2.5048 (67.2); 2.5003 (92.4); 2.4957 (64.5); 2.4911 (29.2); 2.3492 (1.2); 2.3310 (1.3); 2.3270 (1.5); 2.3071 (0.9); 2.2760 (16.0); 2.2557 (1.2); 2.2454 (1.3); 2.2316 (1.3); 2.2140 (0.6); 2.2035 (0.7); 2.1899 (0.7); 2.1715 (1.8); 2.1489 (1.7); 2.1368 (1.5); 2.1141 (1.5); 2.0712 (0.6); 2.0561 (0.8); 2.0435 (0.6); 2.0319 (0.7); 2.0243 (0.9); 2.0194 (0.6); 2.0050 (0.6); 2.0002 (0.8); 1.7207 (0.6); 1.7097 (0.8); 1.6997 (0.7); 1.6879 (0.6); 1.6774 (0.7) I.1-346: 1 H-NMR (400.0 MHz, CDCl3): δ= 7.5510 (1.7); 7.5480 (1.8); 7.5311 (1.9); 7.5280 (2.0); 7.2656 (1.2); 7.2618 (31.4); 7.2470 (1.8); 7.2439 (1.8); 7.2287 (1.6); 7.2255 (1.6); 7.1880 (1.7); 7.1837 (2.1); 7.1689 (1.1); 7.1647 (1.1); 7.1214 (1.6); 7.1130 (27.4); 7.1032 (1.6); 7.1016 (1.6); 7.0986 (1.4); 7.0970 (1.4); 7.0906 (0.6); 7.0834 (0.9); 7.0787 (0.8); 5.4350 (0.6); 5.2975 (2.6); 4.7045 (1.8); 4.6670 (2.0); 4.1255 (1.8); 4.0880 (1.6); 3.9441 (0.6); 3.9335 (0.8); 3.9234 (1.0); 3.9134 (0.8); 3.9027 (0.7); 3.5134 (0.8); 3.4957 (1.8); 3.4801 (2.1); 3.4636 (1.8); 3.4468 (0.8); 2.9380 (2.3); 2.9205 (4.6); 2.9030 (2.1); 2.5063 (1.3); 2.4949 (1.5); 2.4704 (1.8); 2.4587 (1.6); 2.4552 (0.9); 2.4533 (0.9); 2.4507 (0.9); 2.4309 (0.7); 2.4128 (0.9); 2.3987 (1.0); 2.3886 (1.1); 2.3746 (1.1); 2.3458 (0.6); 2.3317 (0.7); 2.3220 (16.0); 2.1953 (0.7); 2.1820 (0.5); 2.1711 (0.6); 2.1627 (0.9); 2.1579 (0.5); 2.1384 (0.7); 2.0789 (1.6); 2.0573 (1.5); 2.0427 (1.4); 2.0212 (1.3); 1.7530 (0.5); 1.7425 (0.7); 1.7325 (0.6); 1.7199 (0.6); 1.7095 (0.6); -0.0002 (9.8) I.1-347: 1 H-NMR (400.0 MHz, CDCl3): δ= 7.5189 (2.4); 7.3490 (1.5); 7.3293 (2.5); 7.3095 (2.6); 7.2916 (0.6); 7.2601 (442.4); 7.2105 (0.7); 7.1380 (0.6); 7.1156 (20.5); 7.1018 (2.4); 7.0828 (1.8); 6.9961 (4.2); 5.2334 (0.7); 4.6919 (1.9); 4.6547 (2.2); 4.1504 (2.0); 4.1128 (1.8); 3.9441 (0.7); 3.9334 (0.8); 3.9235 (1.2); 3.9141 (0.8); 3.9031 (0.7); 3.5006 (0.8); 3.4917 (0.5); 3.4828 (1.3); 3.4673 (1.3); 3.4442 (1.2); 3.4291 (1.3); 3.4113 (0.8); 2.8044 (2.1); 2.7870 (4.3); 2.7695 (2.0); 2.4961 (1.4); 2.4850 (1.4); 2.4683 (1.0); 2.4602 (1.5); 2.4488 (2.4); 2.4257 (0.8); 2.4190 (0.9); 2.4045 (1.1); 2.3948 (1.2); 2.3805 (1.3); 2.3519 (0.6); 2.3377 (0.6); 2.3210 (16.0); 2.2097 (0.8); 2.1963 (0.5); 2.1857 (0.6); 2.1776 (0.8); 2.1530 (0.7); 2.0640 (1.6); 2.0427 (1.6); 2.0278 (1.4); 2.0066 (1.8); 1.7427 (0.5); 1.7319 (0.7); 1.7222 (0.7); 1.7095 (0.7); 1.6986 (0.5); 1.5459 (33.9); 0.0080 (3.5); -0.0002 (117.5); -0.0085 (3.6) I.1-348: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.9220 (1.5); 8.9005 (1.5); 7.3943 (0.6); 7.3755 (1.2); 7.3729 (1.1); 7.3581 (1.8); 7.3476 (1.7); 7.3421 (1.3); 7.3396 (1.9); 7.3353 (1.4); 7.3314 (2.3); 7.3287 (3.6); 7.3265 (3.2); 7.3209 (5.2); 7.3182 (4.8); 7.3109 (4.6); 7.3029 (5.3); 7.2623 (2.5); 7.2530 (6.0); 7.2499 (6.7); 7.2345 (5.8); 7.2314 (3.4); 7.2297 (3.5); 7.2146 (1.5); 7.2106 (1.3); 7.1988 (3.3); 7.1956 (3.5); 7.1929 (2.9); 7.1783 (0.8); 7.1586 (0.8); 7.1534 (0.6); 7.1398 (1.6); 7.1340 (1.5); 7.1246 (1.1); 7.1188 (1.3); 7.1118 (2.0); 7.1086 (2.1); 7.0920 (0.7); 6.1076 (1.8); 6.0862 (1.8); 4.7515 (1.7); 4.7124 (1.9); 4.0426 (1.6); 4.0032 (1.5); 3.7133 (0.6); 3.7027 (0.8); 3.6918 (0.7); 3.4521 (3.7); 3.1667 (16.0); 2.6434 (0.9); 2.6324 (0.9); 2.6084 (1.2); 2.5978 (1.1); 2.5712 (0.8); 2.5522 (2.2); 2.5337 (2.4); 2.5229 (1.1); 2.5095 (22.9); 2.5050 (50.2); 2.5003 (70.5); 2.4957 (49.2); 2.4911 (21.7); 2.3931 (0.7); 2.3824 (1.3); 2.3721 (0.8); 2.3602 (1.3); 2.3479 (1.5); 2.3266 (1.4); 2.2769 (0.6); 2.2660 (0.7); 2.2525 (0.9); 2.2420 (0.8); 2.2104 (0.5); 2.0605 (0.5); 2.0378 (0.5); 2.0289 (0.7); 2.0061 (0.6); 1.7644 (0.7); 1.7552 (0.7); 1.1071 (5.3); 1.0883 (12.6); 1.0694 (5.2); 0.0079 (0.8); -0.0002 (27.1); -0.0085 (0.8) I.1-349: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.8214 (4.4); 7.2304 (1.4); 7.2166 (4.2); 7.1896 (0.7); 7.1710 (1.1); 7.1633 (1.3); 7.1497 (1.1); 7.1410 (1.6); 7.1228 (1.0); 5.9803 (0.5); 4.8016 (1.1); 4.7619 (1.2); 4.7287 (0.7); 4.1215 (1.2); 4.0826 (1.1); 3.7849 (0.7); 3.5782 (12.4); 3.4873 (16.0); 3.2242 (3.0); 3.1860 (0.7); 3.1658 (1.0); 2.8426 (0.6); 2.7967 (0.7); 2.6743 (1.5); 2.6699 (2.2); 2.6652 (1.4); 2.6180 (1.7); 2.6002 (2.4); 2.5820 (1.3); 2.5400 (1.9); 2.5233 (5.3); 2.5186 (7.7); 2.5099 (112.4); 2.5053 (247.0); 2.5007 (345.6); 2.4961 (240.3); 2.4915 (106.3); 2.4321 (0.8); 2.3322 (1.5); 2.3274 (2.4); 2.3228 (1.5); 2.3015 (0.8); 2.2678 (0.6); 2.1625 (0.8); 1.8416 (0.5); 1.1493 (4.0); 1.1418 (1.7); 1.1305 (9.5); 1.1230 (3.6); 1.1117 (3.9); 1.1041 (1.7); 0.0080 (3.2); -0.0002 (121.1); -0.0086 (3.4) I.1-350: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 10.8364 (3.1); 8.3208 (2.1); 8.3086 (2.3); 8.3010 (2.4); 8.2892 (2.0); 7.5306 (4.2); 7.5110 (4.4); 7.3301 (4.3); 7.3099 (4.9); 7.1204 (8.2); 7.1030 (6.7); 7.0791 (8.1); 7.0734 (6.0); 7.0681 (6.8); 7.0587 (5.3); 7.0559 (5.4); 7.0353 (2.8); 6.9941 (5.6); 6.9848 (3.9); 6.9741 (4.3); 6.9672 (4.2); 6.9651 (4.4); 6.9475 (2.0); 4.6162 (1.9); 4.5793 (2.5); 4.5468 (2.0); 4.5167 (0.7); 4.5041 (0.9); 4.4938 (1.7); 4.4815 (1.7); 4.4733 (1.6); 4.4610 (1.6); 4.4501 (0.8); 4.4381 (0.6); 4.0020 (2.1); 3.9639 (2.0); 3.8724 (2.2); 3.8341 (2.1); 3.6021 (2.6); 3.4973 (1.2); 3.4431 (2.0); 3.3438 (107.3); 3.1865 (1.9); 3.1743 (1.9); 3.1499 (2.6); 3.1384 (2.3); 3.0029 (1.9); 2.9956 (1.9); 2.9796 (2.0); 2.9721 (2.2); 2.9584 (1.6); 2.9430 (1.6); 2.9354 (1.5); 2.6704 (2.0); 2.6011 (2.0); 2.5058 (90.1); 2.5014 (117.7); 2.4971 (91.6); 2.4567 (3.0); 2.4445 (2.4); 2.3644 (0.7); 2.3327 (1.1); 2.3282 (1.3); 2.3111 (1.0); 2.2890 (1.8); 2.2638 (16.0); 2.2553 (15.1); 2.2268 (2.3); 2.2052 (1.2); 2.1926 (1.2); 2.1791 (1.4); 2.1739 (1.5); 2.1688 (1.7); 2.1507 (2.9); 2.1360 (2.0); 2.1264 (2.8); 2.1173 (2.2); 2.1024 (2.0); 2.0940 (2.3); 2.0853 (2.8); 2.0734 (6.2); 2.0707 (2.6); 1.9040 (0.8); 1.8913 (0.7); 1.8801 (0.8); 1.8717 (1.0); 1.8483 (0.8); 1.7845 (0.7); 1.7728 (0.6); 1.7613 (0.8); 1.7530 (0.9); 1.7295 (0.8); 1.6613 (0.7); 1.6506 (0.8); 1.6406 (0.9); 1.6286 (0.8); 1.6186 (0.7); 1.4158 (0.6); 1.4050 (0.8); 1.3948 (0.8); 1.3834 (0.8); 1.3729 (0.7); -0.0002 (6.4) I.1-351: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 12.7159 (1.6); 8.3393 (1.5); 8.3200 (1.5); 7.2542 (1.2); 7.2372 (3.2); 7.2324 (2.9); 7.2199 (7.4); 7.2060 (10.1); 7.1909 (3.5); 7.1834 (3.0); 7.1658 (1.5); 7.1466 (2.0); 7.1404 (1.7); 7.1308 (1.0); 7.1248 (1.0); 7.0815 (2.5); 7.0625 (1.7); 4.7171 (2.1); 4.6779 (2.4); 4.4317 (0.7); 4.4205 (1.0); 4.4071 (1.1); 4.3997 (1.0); 4.3872 (0.9); 3.9790 (2.1); 3.9390 (1.9); 3.5341 (1.0); 3.3118 (379.1); 3.1656 (0.9); 3.0778 (1.1); 3.0654 (1.2); 3.0424 (1.4); 3.0316 (1.3); 2.8309 (1.4); 2.8048 (1.5); 2.7961 (1.2); 2.7710 (1.1); 2.6790 (2.0); 2.6744 (4.0); 2.6697 (5.9); 2.6651 (4.0); 2.5940 (1.1); 2.5713 (2.7); 2.5561 (4.0); 2.5400 (4.2); 2.5232 (14.8); 2.5185 (21.6); 2.5098 (316.9); 2.5052 (689.5); 2.5006 (962.0); 2.4960 (677.0); 2.4914 (302.2); 2.4569 (1.8); 2.4473 (1.9); 2.4375 (1.4); 2.3367 (2.0); 2.3321 (4.2); 2.3274 (5.9); 2.3228 (4.6); 2.3000 (1.1); 2.2787 (1.0); 2.2577 (1.6); 2.2349 (0.9); 2.2012 (1.0); 2.1845 (1.7); 2.1774 (1.4); 2.1613 (2.0); 2.1504 (1.6); 2.1269 (1.6); 2.0731 (1.2); 1.9056 (0.8); 1.8735 (1.0); 1.8530 (0.9); 1.6915 (1.0); 1.1217 (7.0); 1.1029 (16.0); 1.0840 (6.6); 0.1459 (1.5); 0.0302 (0.6); 0.0142 (1.3); 0.0080 (14.8); 0.0063 (5.2); 0.0055 (5.7); 0.0046 (6.9); -0.0002 (475.2); -0.0060 (5.2); -0.0068 (4.5); -0.0085 (13.8); -0.0115 (1.9); -0.0140 (1.2); -0.0155 (1.1); -0.1497 (1.4) I.1-352: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.9141 (1.9); 8.8929 (2.0); 7.3635 (0.5); 7.3443 (3.4); 7.3409 (3.7); 7.3371 (1.8); 7.3281 (4.4); 7.3254 (6.0); 7.3225 (7.0); 7.3199 (6.3); 7.3077 (5.1); 7.3064 (5.1); 7.3042 (6.0); 7.2603 (3.2); 7.2532 (12.8); 7.2450 (4.4); 7.2347 (7.2); 7.2332 (6.8); 7.2311 (5.7); 7.2264 (1.5); 7.2221 (0.9); 7.2180 (0.9); 7.1877 (0.6); 7.1839 (0.6); 7.1750 (0.6); 7.1712 (0.7); 7.1678 (1.0); 7.1642 (1.1); 7.1549 (1.0); 7.1517 (1.2); 7.1476 (0.7); 7.1437 (0.7); 7.1346 (0.6); 7.1313 (0.6); 7.0654 (1.1); 7.0494 (1.5); 7.0300 (0.8); 6.1062 (2.4); 6.0851 (2.4); 4.7257 (1.7); 4.6860 (2.0); 4.2208 (2.1); 4.1811 (1.8); 3.8225 (0.7); 3.8118 (1.0); 3.8016 (1.2); 3.7914 (1.0); 3.7810 (0.7); 3.3941 (5.4); 3.3384 (0.6); 3.1671 (16.0); 2.6715 (1.6); 2.6651 (0.7); 2.6606 (1.5); 2.6368 (1.7); 2.6258 (1.5); 2.5233 (1.9); 2.5186 (2.6); 2.5099 (29.6); 2.5054 (63.4); 2.5008 (87.9); 2.4962 (61.6); 2.4916 (27.1); 2.4554 (0.5); 2.4507 (0.6); 2.3843 (1.9); 2.3625 (2.1); 2.3495 (1.5); 2.3390 (1.3); 2.3276 (2.0); 2.3191 (1.4); 2.2967 (0.9); 2.2678 (0.9); 2.2547 (1.0); 2.2438 (1.3); 2.2308 (1.3); 2.2018 (0.6); 2.1891 (0.6); 2.1049 (0.8); 2.0930 (0.6); 2.0853 (0.5); 2.0811 (0.8); 2.0732 (1.2); 2.0536 (0.6); 2.0494 (0.8); 1.7786 (0.6); 1.7678 (0.9); 1.7578 (0.8); 1.7464 (0.8); 1.7362 (0.8); 0.0080 (0.8); -0.0002 (25.9); -0.0085 (0.7) I.1-353: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 10.7926 (1.6); 8.0592 (0.8); 8.0451 (1.6); 8.0306 (0.8); 7.5178 (2.2); 7.4980 (2.3); 7.3369 (1.9); 7.3347 (3.0); 7.3326 (2.0); 7.3167 (2.2); 7.3146 (3.6); 7.3124 (2.2); 7.1404 (2.5); 7.1205 (9.4); 7.1008 (7.9); 7.0802 (2.6); 7.0758 (1.7); 7.0728 (1.5); 7.0580 (2.0); 7.0553 (2.6); 7.0379 (1.7); 7.0350 (1.6); 6.9835 (2.0); 6.9809 (2.1); 6.9659 (1.8); 6.9636 (3.0); 6.9612 (2.2); 6.9463 (1.4); 6.9437 (1.4); 4.6629 (1.9); 4.6249 (2.2); 4.0034 (2.2); 3.9653 (2.0); 3.7194 (0.7); 3.7082 (0.9); 3.6975 (1.0); 3.6878 (0.9); 3.6770 (0.7); 3.3680 (40.1); 3.3427 (1.8); 3.3249 (2.4); 3.3102 (2.3); 3.2915 (1.2); 2.8068 (2.1); 2.7887 (3.5); 2.7704 (1.8); 2.5232 (0.8); 2.5185 (1.3); 2.5098 (22.1); 2.5053 (47.7); 2.5006 (66.6); 2.4960 (47.1); 2.4914 (20.5); 2.4733 (1.8); 2.4622 (1.6); 2.3502 (0.5); 2.3274 (1.5); 2.3082 (1.0); 2.2749 (16.0); 2.2519 (1.2); 2.2383 (1.2); 2.2279 (1.3); 2.2142 (1.3); 2.1964 (0.6); 2.1861 (0.7); 2.1724 (0.6); 2.1192 (1.6); 2.0967 (1.6); 2.0847 (1.4); 2.0621 (1.4); 2.0192 (0.8); 2.0147 (0.5); 2.0066 (0.6); 1.9951 (0.8); 1.9876 (0.9); 1.9828 (0.6); 1.9634 (0.8); 1.6758 (0.6); 1.6654 (0.8); 1.6549 (0.7); 1.6438 (0.7); 1.6331 (0.7); -0.0002 (3.3) I.1-355: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.1786 (1.4); 7.1577 (4.6); 7.1378 (4.1); 7.1171 (1.4); 7.1093 (1.6); 7.0886 (0.7); 4.7069 (1.2); 4.6957 (0.6); 4.6688 (1.2); 4.1766 (2.4); 4.0614 (1.2); 4.0320 (5.9); 4.0235 (1.3); 3.9483 (0.6); 3.7206 (0.7); 3.7103 (0.6); 3.6726 (7.2); 3.6165 (16.0); 3.3883 (13.2); 3.1656 (1.7); 2.9334 (14.4); 2.8043 (0.7); 2.7949 (0.7); 2.7660 (5.8); 2.7547 (0.9); 2.6698 (1.3); 2.6650 (1.0); 2.6044 (0.9); 2.5852 (2.6); 2.5658 (2.8); 2.5472 (0.8); 2.5231 (2.1); 2.5184 (3.8); 2.5098 (71.5); 2.5052 (157.3); 2.5006 (220.5); 2.4960 (154.6); 2.4914 (69.7); 2.4725 (1.7); 2.4678 (1.5); 2.4639 (1.5); 2.4461 (1.8); 2.4240 (1.0); 2.3989 (0.8); 2.3752 (0.6); 2.3368 (1.0); 2.3319 (1.1); 2.3274 (1.4); 2.3227 (1.1); 2.2621 (0.5); 2.2497 (0.7); 2.2374 (0.8); 2.2255 (0.8); 2.0731 (1.0); 1.6253 (0.5); 1.6027 (0.5); 1.1839 (2.0); 1.1785 (4.2); 1.1650 (4.6); 1.1595 (9.6); 1.1460 (2.0); 1.1405 (4.1); 0.0080 (3.0); -0.0002 (115.4); -0.0086 (3.5); -0.0332 (0.6); -0.0506 (0.6) I.1-356: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.1476 (0.6); 8.1335 (1.1); 8.1193 (0.5); 7.3701 (0.7); 7.3660 (0.8); 7.3439 (0.7); 7.1960 (0.7); 7.1921 (0.8); 7.1795 (0.8); 7.0823 (0.7); 7.0664 (1.0); 7.0468 (0.5); 4.7458 (1.1); 4.7061 (1.3); 4.2400 (1.4); 4.2005 (1.3); 3.7998 (0.7); 3.7896 (0.9); 3.7795 (0.7); 3.7691 (0.5); 3.3360 (47.4); 3.1857 (0.5); 3.1333 (1.0); 3.1148 (2.7); 3.1036 (3.3); 3.0965 (3.0); 3.0854 (2.8); 3.0781 (1.8); 3.0670 (1.0); 3.0248 (0.7); 3.0116 (1.0); 2.9984 (1.0); 2.9842 (1.1); 2.9725 (0.7); 2.5314 (1.1); 2.5197 (1.9); 2.5109 (16.0); 2.5063 (35.2); 2.5017 (49.4); 2.4970 (35.0); 2.4924 (15.3); 2.4849 (1.5); 2.3681 (0.8); 2.3490 (0.8); 2.3261 (0.8); 2.3009 (0.6); 2.2873 (0.8); 2.2768 (1.0); 2.2634 (0.9); 2.2350 (1.6); 2.2215 (0.5); 2.2137 (1.2); 2.1998 (1.0); 2.1784 (1.0); 2.1454 (0.6); 2.1214 (0.5); 2.1141 (0.7); 2.0897 (0.5); 2.0735 (1.1); 1.7614 (0.7); 1.7518 (0.9); 1.7357 (1.2); 1.7297 (1.1); 1.7165 (1.2); 1.7073 (1.0); 1.6946 (0.9); 1.1858 (7.0); 1.1677 (16.0); 1.1495 (6.7); -0.0002 (1.4) I.1-357: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 11.8206 (1.5); 7.2326 (1.0); 7.2291 (1.2); 7.2204 (1.9); 7.2176 (2.9); 7.2146 (4.5); 7.2017 (0.6); 7.1863 (0.9); 7.1796 (0.8); 7.1675 (1.2); 7.1602 (1.1); 7.1527 (0.6); 7.1459 (0.7); 7.1051 (1.6); 7.0867 (1.0); 4.7484 (1.5); 4.7089 (1.6); 4.0799 (1.4); 4.0407 (1.3); 3.7407 (0.5); 3.7292 (0.8); 3.7183 (0.5); 3.3981 (15.1); 3.1911 (16.0); 3.1657 (2.3); 2.7257 (0.8); 2.7156 (0.9); 2.6876 (1.1); 2.6776 (1.2); 2.6698 (0.9); 2.6652 (0.6); 2.6293 (0.6); 2.6257 (0.6); 2.6109 (1.7); 2.6069 (1.8); 2.5920 (1.9); 2.5882 (1.9); 2.5698 (0.8); 2.5401 (0.5); 2.5326 (0.5); 2.5233 (2.1); 2.5186 (3.1); 2.5099 (43.3); 2.5053 (94.4); 2.5007 (131.7); 2.4961 (92.3); 2.4915 (40.9); 2.4390 (0.6); 2.4317 (1.1); 2.4186 (0.7); 2.4092 (1.1); 2.3963 (1.2); 2.3713 (1.0); 2.3321 (0.6); 2.3275 (0.8); 2.3229 (0.6); 2.3114 (0.5); 2.3009 (0.7); 2.2869 (0.8); 2.2765 (0.8); 2.2450 (0.5); 2.2349 (0.5); 2.1669 (0.5); 2.1343 (0.6); 1.7642 (0.7); 1.7545 (0.6); 1.1511 (4.8); 1.1324 (11.3); 1.1135 (4.7); 0.0080 (2.1); 0.0064 (0.6); 0.0055 (0.7); 0.0047 (0.9); 0.0039 (1.1); -0.0002 (66.5); -0.0059 (0.7); -0.0067 (0.6); -0.0085 (1.9) I.1-358: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 12.7555 (1.2); 8.3581 (1.8); 8.3378 (2.1); 7.2800 (1.8); 7.2618 (4.3); 7.2440 (5.2); 7.2321 (1.6); 7.2148 (8.4); 7.2066 (5.7); 7.1980 (9.5); 7.1945 (9.5); 7.1858 (3.4); 7.1679 (1.1); 7.1602 (1.5); 7.1534 (1.1); 7.1410 (2.2); 7.1344 (1.7); 7.1258 (1.1); 7.1195 (1.0); 7.0805 (3.3); 7.0612 (2.1); 4.7139 (2.4); 4.6744 (2.7); 4.4933 (0.7); 4.4821 (0.8); 4.4687 (1.1); 4.4605 (1.1); 4.4474 (0.9); 4.4358 (0.8); 4.0230 (2.3); 3.9834 (2.3); 3.5631 (1.2); 3.3137 (221.5); 3.1655 (1.2); 3.0910 (1.2); 3.0793 (1.4); 3.0563 (1.6); 3.0448 (1.5); 2.8332 (1.6); 2.8077 (1.9); 2.7991 (1.7); 2.7739 (1.3); 2.6743 (1.7); 2.6697 (2.4); 2.6652 (1.8); 2.5827 (3.3); 2.5787 (3.4); 2.5641 (3.2); 2.5399 (3.5); 2.5231 (9.2); 2.5097 (149.9); 2.5052 (307.9); 2.5007 (417.4); 2.4961 (298.5); 2.4916 (138.7); 2.4493 (1.8); 2.4391 (1.8); 2.3947 (0.7); 2.3321 (2.3); 2.3275 (2.8); 2.3228 (2.1); 2.2929 (1.3); 2.2722 (1.7); 2.2497 (0.9); 2.2002 (1.0); 2.1898 (1.3); 2.1763 (1.4); 2.1613 (2.4); 2.1483 (1.0); 2.1385 (1.8); 2.1271 (1.9); 2.1041 (1.4); 2.0731 (1.0); 1.8053 (0.8); 1.7853 (0.8); 1.7749 (1.0); 1.7527 (0.8); 1.4425 (0.7); 1.4182 (1.0); 1.4083 (1.0); 1.1223 (7.5); 1.1035 (16.0); 1.0847 (7.1); 0.1461 (0.5); 0.0079 (6.0); -0.0002 (163.4); -0.0085 (6.2); -0.1496 (0.6) I.1-359: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.8770 (2.3); 8.8727 (2.5); 8.8665 (2.5); 8.8622 (2.5); 8.6378 (0.8); 8.6231 (1.5); 8.6083 (0.7); 8.3395 (1.4); 8.3370 (1.5); 8.3183 (1.6); 8.3159 (1.5); 7.9876 (2.6); 7.9660 (2.9); 7.7767 (2.6); 7.7733 (2.7); 7.6512 (2.2); 7.6463 (2.0); 7.6295 (1.9); 7.6245 (1.8); 7.5414 (2.5); 7.5309 (2.4); 7.5207 (2.4); 7.5102 (2.4); 7.1485 (0.7); 7.1295 (3.0); 7.1098 (8.4); 7.0980 (8.4); 7.0919 (2.0); 7.0826 (0.9); 7.0771 (1.9); 4.6895 (1.8); 4.6514 (2.0); 4.4621 (1.7); 4.4482 (3.1); 4.4343 (1.7); 4.0218 (2.0); 4.0107 (0.5); 3.9839 (1.8); 3.7722 (0.7); 3.7614 (0.9); 3.7507 (1.0); 3.7411 (0.9); 3.7304 (0.7); 3.3420 (12.1); 3.1665 (5.7); 3.1518 (0.6); 3.1344 (0.6); 3.1162 (0.6); 3.0085 (0.5); 2.7663 (3.1); 2.7570 (2.6); 2.6703 (0.6); 2.6323 (1.4); 2.6215 (1.3); 2.5974 (1.5); 2.5867 (1.4); 2.5516 (0.6); 2.5238 (1.1); 2.5191 (1.7); 2.5104 (29.4); 2.5058 (65.2); 2.5012 (91.5); 2.4966 (64.5); 2.4920 (29.0); 2.4039 (0.6); 2.3840 (0.7); 2.3614 (1.2); 2.3424 (1.0); 2.3377 (1.0); 2.3328 (0.6); 2.3280 (0.8); 2.3188 (1.1); 2.2781 (4.3); 2.2671 (16.0); 2.2583 (2.3); 2.2475 (2.1); 2.2447 (1.8); 2.2350 (1.6); 2.2270 (0.8); 2.2128 (1.5); 2.2026 (0.7); 2.1077 (0.6); 2.0885 (0.7); 2.0839 (0.5); 2.0761 (0.6); 2.0737 (0.6); 2.0695 (0.5); 2.0643 (0.7); 2.0571 (0.9); 2.0521 (0.6); 2.0376 (0.5); 2.0327 (0.7); 1.7924 (0.8); 1.7793 (0.8); 1.7687 (1.0); 1.7579 (0.7); 1.7471 (0.7); 1.7365 (0.7); 1.7260 (0.5); 1.1941 (1.0); 1.1759 (2.0); 1.1576 (1.0); 1.0701 (1.6); 1.0521 (3.6); 1.0342 (1.6); 0.0081 (1.7); -0.0002 (63.2); -0.0085 (1.9) I.1-360: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.4942 (4.6); 8.4801 (9.1); 8.4658 (4.6); 7.3832 (2.4); 7.3792 (2.7); 7.3629 (9.3); 7.3527 (3.5); 7.3415 (12.6); 7.3327 (5.6); 7.3247 (10.1); 7.3197 (6.8); 7.3126 (3.3); 7.3030 (5.2); 7.2408 (6.2); 7.2344 (6.5); 7.2173 (7.2); 7.2146 (7.8); 7.2109 (8.0); 7.2082 (8.1); 7.2046 (4.1); 7.2005 (3.8); 7.1912 (9.3); 7.1846 (12.3); 7.1809 (6.8); 7.1716 (5.7); 7.1682 (6.4); 7.1643 (4.0); 7.1602 (3.7); 7.1512 (3.2); 7.1478 (3.4); 7.0717 (8.1); 7.0690 (10.1); 7.0655 (8.6); 7.0505 (15.9); 7.0481 (16.0); 7.0441 (10.6); 7.0417 (9.1); 7.0326 (4.9); 7.0292 (6.7); 7.0267 (5.3); 7.0226 (3.9); 7.0202 (3.8); 4.7280 (9.4); 4.6882 (10.8); 4.2834 (0.8); 4.2693 (1.0); 4.2412 (12.7); 4.2308 (13.0); 4.2180 (13.0); 4.2029 (1.3); 4.1780 (10.4); 3.8238 (3.0); 3.8131 (5.3); 3.8026 (7.3); 3.7924 (8.9); 3.7824 (8.3); 3.7719 (7.4); 3.7608 (6.2); 3.7323 (6.0); 2.6765 (1.3); 2.6719 (1.8); 2.6673 (1.3); 2.5923 (7.7); 2.5810 (7.7); 2.5573 (8.8); 2.5458 (8.3); 2.5254 (5.2); 2.5207 (7.8); 2.5119 (100.3); 2.5074 (218.4); 2.5028 (303.3); 2.4982 (214.5); 2.4936 (95.6); 2.4578 (1.7); 2.4532 (1.8); 2.4485 (1.1); 2.3866 (2.1); 2.3670 (2.9); 2.3444 (6.6); 2.3342 (2.0); 2.3249 (7.8); 2.3021 (5.3); 2.2789 (5.6); 2.2719 (10.6); 2.2657 (7.1); 2.2549 (8.9); 2.2503 (10.8); 2.2417 (8.7); 2.2369 (11.2); 2.2238 (3.0); 2.2148 (9.5); 2.2000 (3.8); 2.1410 (2.6); 2.1216 (4.7); 2.1174 (3.0); 2.1094 (3.5); 2.1021 (3.0); 2.0977 (4.3); 2.0900 (5.8); 2.0857 (3.6); 2.0783 (2.2); 2.0704 (3.2); 2.0660 (4.3); 2.0466 (1.8); 1.7666 (2.4); 1.7540 (3.6); 1.7432 (5.0); 1.7331 (4.3); 1.7217 (4.2); 1.7114 (4.4); 1.7009 (2.6); 1.6878 (1.9); 0.0080 (3.5); -0.0002 (114.0); -0.0085 (3.3); -0.0499 (0.6) I.1-361: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 10.4717 (6.2); 10.4673 (6.3); 8.0564 (2.9); 8.0424 (6.0); 8.0283 (3.0); 7.3806 (1.5); 7.3767 (1.6); 7.3601 (3.2); 7.3561 (3.5); 7.3503 (1.9); 7.3404 (2.3); 7.3341 (3.5); 7.3302 (3.1); 7.3140 (1.9); 7.3101 (1.9); 7.2094 (1.9); 7.2055 (2.1); 7.1966 (2.0); 7.1929 (2.5); 7.1894 (3.6); 7.1858 (4.0); 7.1766 (3.5); 7.1733 (4.0); 7.1692 (2.4); 7.1652 (2.4); 7.1563 (2.0); 7.1528 (2.2); 7.1191 (14.0); 7.1181 (14.5); 7.0977 (15.2); 7.0966 (16.0); 7.0758 (3.8); 7.0597 (5.1); 7.0565 (4.9); 7.0403 (2.7); 7.0115 (10.8); 7.0060 (10.6); 6.8070 (12.8); 6.8013 (13.5); 6.5921 (8.9); 6.5864 (8.4); 6.5706 (8.2); 6.5650 (8.0); 4.7455 (5.8); 4.7058 (6.7); 4.2352 (7.3); 4.1955 (6.5); 3.8190 (9.1); 3.8084 (10.1); 3.7979 (10.6); 3.7878 (10.7); 3.7778 (9.2); 3.7673 (7.4); 3.7565 (5.4); 3.5746 (0.7); 3.3148 (0.8); 3.3007 (2.5); 3.2824 (5.1); 3.2689 (5.6); 3.2574 (5.1); 3.2397 (2.7); 3.2252 (0.8); 3.1692 (2.7); 2.7061 (6.9); 2.6876 (12.8); 2.6693 (6.5); 2.5408 (0.7); 2.5275 (4.9); 2.5244 (3.5); 2.5192 (4.6); 2.5108 (55.1); 2.5062 (120.4); 2.5016 (168.8); 2.4969 (119.4); 2.4924 (58.0); 2.4813 (6.4); 2.3951 (1.4); 2.3754 (1.9); 2.3722 (2.0); 2.3529 (4.1); 2.3331 (4.6); 2.3190 (0.9); 2.3106 (3.1); 2.2751 (3.0); 2.2618 (3.7); 2.2510 (4.6); 2.2378 (4.4); 2.2334 (2.2); 2.2200 (1.9); 2.2089 (3.0); 2.2036 (6.0); 2.1962 (2.9); 2.1820 (5.6); 2.1688 (4.8); 2.1472 (4.7); 2.1271 (1.6); 2.1076 (2.8); 2.1034 (1.9); 2.0953 (2.2); 2.0881 (1.9); 2.0836 (2.7); 2.0760 (3.6); 2.0730 (6.9); 2.0644 (1.4); 2.0564 (2.0); 2.0519 (2.6); 2.0324 (1.2); 1.7572 (1.5); 1.7447 (2.2); 1.7339 (3.0); 1.7235 (2.6); 1.7124 (2.6); 1.7020 (2.7); 1.6912 (1.6); 1.6784 (1.2); -0.0002 (6.7) I.1-362: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 7.9622 (0.5); 7.1434 (0.9); 7.1232 (3.1); 7.1082 (3.4); 7.1027 (0.6); 7.0875 (0.9); 4.6629 (0.8); 4.6249 (0.9); 4.0121 (0.9); 3.9741 (0.8); 3.5746 (16.0); 3.5056 (1.8); 3.0376 (1.0); 3.0337 (0.8); 3.0234 (0.8); 3.0196 (1.0); 2.5105 (3.6); 2.5060 (8.0); 2.5013 (11.6); 2.4967 (7.8); 2.4921 (3.7); 2.4666 (0.7); 2.4556 (0.7); 2.3072 (1.3); 2.3019 (0.5); 2.2885 (2.7); 2.2751 (6.9); 2.2702 (2.6); 2.2562 (0.5); 2.2460 (0.6); 2.2320 (0.5); 2.1100 (0.7); 2.0875 (0.7); 2.0753 (0.6); 2.0528 (0.6); 1.6560 (0.6); 1.6388 (1.2); 1.6204 (1.6); 1.6024 (1.0); -0.0002 (0.6) I.1-363: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 9.1990 (1.9); 9.1917 (1.8); 8.3022 (0.5); 8.2973 (0.5); 7.1311 (0.9); 7.1107 (2.3); 7.0920 (1.7); 7.0748 (1.7); 7.0547 (0.7); 6.9941 (1.7); 6.9734 (2.0); 6.6563 (1.4); 6.6509 (0.6); 6.6469 (1.5); 6.6408 (0.7); 6.6350 (1.3); 6.6304 (0.6); 6.6255 (1.3); 3.3215 (48.3); 3.2978 (2.4); 2.5101 (7.2); 2.5055 (15.5); 2.5009 (21.9); 2.4963 (15.2); 2.4917 (7.0); 2.4665 (0.6); 2.2688 (4.5); 2.0851 (3.3); 2.0725 (2.1); 1.3289 (16.0); 1.3189 (15.4); -0.0002 (16.2); -0.0028 (0.9) I.1-365: 1 H-NMR (400.1 MHz, CDCl3): δ= 7.5206 (1.2); 7.3094 (0.6); 7.2903 (0.4); 7.2618 (208.0); 7.2093 (0.4); 7.1312 (0.4); 7.1177 (0.8); 7.1064 (1.5); 7.0961 (1.0); 7.0888 (1.6); 7.0817 (1.7); 7.0728 (1.0); 7.0631 (6.2); 7.0529 (5.7); 7.0444 (2.2); 7.0395 (1.8); 6.9978 (1.2); 4.9135 (2.3); 4.8746 (2.5); 4.7178 (1.0); 4.7067 (1.0); 4.6906 (2.0); 4.6796 (2.0); 4.6635 (1.1); 4.6521 (1.0); 4.2430 (3.1); 4.2044 (2.9); 3.8931 (0.5); 3.8831 (0.9); 3.8726 (1.3); 3.8623 (1.5); 3.8510 (1.3); 3.8402 (0.9); 3.8304 (0.5); 2.7332 (2.0); 2.7239 (2.0); 2.6955 (2.5); 2.6862 (2.4); 2.5623 (0.5); 2.5439 (0.7); 2.5389 (0.7); 2.5202 (1.8); 2.5012 (1.5); 2.4963 (1.3); 2.4776 (1.4); 2.4394 (1.2); 2.4252 (1.4); 2.4149 (1.7); 2.4020 (4.0); 2.3796 (2.7); 2.3720 (1.2); 2.3647 (2.3); 2.3581 (1.1); 2.3420 (2.0); 2.2946 (0.7); 2.2754 (1.1); 2.2699 (0.7); 2.2623 (0.9); 2.2560 (0.8); 2.2515 (0.9); 2.2432 (1.2); 2.2376 (0.8); 2.2323 (0.5); 2.2234 (0.8); 2.2184 (0.9); 2.1989 (0.5); 1.9539 (1.2); 1.9239 (1.3); 1.9009 (0.6); 1.8883 (0.9); 1.8762 (1.2); 1.8663 (1.0); 1.8530 (1.0); 1.8429 (1.1); 1.8321 (0.8); 1.8185 (0.9); 1.8074 (1.0); 1.8008 (1.0); 1.7898 (1.4); 1.7837 (1.2); 1.7725 (1.0); 1.7654 (1.0); 1.7544 (0.4); 1.7487 (0.4); 1.6932 (2.4); 1.6669 (2.4); 1.6610 (2.5); 1.6525 (1.6); 1.6058 (0.5); 1.5582 (142.5); 1.5209 (0.4); 1.5050 (0.7); 1.4818 (1.0); 1.4741 (1.0); 1.4660 (0.9); 1.4361 (0.5); 1.4284 (0.4); 1.3964 (0.5); 1.3897 (0.9); 1.3819 (0.5); 1.3595 (1.5); 1.3388 (0.7); 1.3309 (1.0); 1.3237 (0.6); 1.0960 (0.4); 1.0857 (0.5); 1.0594 (1.1); 1.0533 (1.3); 1.0283 (1.5); 1.0213 (1.2); 0.9961 (1.6); 0.9665 (2.3); 0.9381 (2.5); 0.9105 (15.1); 0.8991 (16.0); 0.8943 (14.6); 0.8818 (14.2); 0.8477 (1.0); 0.8190 (0.5); 0.7477 (13.4); 0.7303 (12.9); 0.1460 (0.4); 0.0074 (4.4) I.1-366: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 7.1490 (2.2); 7.1288 (7.6); 7.1149 (7.5); 7.1000 (2.1); 7.0946 (1.9); 7.0767 (1.2); 5.0631 (1.0); 5.0498 (1.0); 4.7472 (1.2); 4.7091 (1.6); 4.7004 (1.1); 4.6620 (1.4); 4.2185 (1.2); 4.2132 (1.2); 4.2007 (1.3); 4.1955 (1.4); 4.1779 (0.6); 4.1690 (0.9); 4.1514 (1.4); 4.1337 (1.1); 4.1266 (1.1); 4.1156 (1.7); 4.1089 (2.1); 4.1059 (1.8); 4.0977 (3.6); 4.0912 (1.9); 4.0882 (1.7); 4.0799 (3.3); 4.0706 (1.4); 4.0621 (1.0); 4.0352 (1.3); 3.9976 (1.0); 3.9528 (0.5); 3.7401 (0.5); 3.7273 (0.8); 3.7173 (1.1); 3.7077 (1.1); 3.6979 (0.7); 3.6841 (0.8); 3.3160 (77.1); 3.2923 (2.8); 3.0160 (3.0); 2.9754 (0.7); 2.9687 (0.6); 2.8546 (0.6); 2.8446 (0.5); 2.8149 (0.7); 2.8037 (0.8); 2.7923 (0.5); 2.7622 (0.8); 2.7531 (0.8); 2.6698 (0.5); 2.5401 (0.5); 2.5233 (2.0); 2.5186 (2.7); 2.5099 (31.4); 2.5054 (67.6); 2.5007 (94.4); 2.4961 (65.4); 2.4916 (29.4); 2.4774 (1.0); 2.4665 (0.5); 2.4616 (0.8); 2.4511 (0.5); 2.4380 (0.7); 2.4300 (0.6); 2.4132 (1.2); 2.3902 (1.4); 2.3739 (1.0); 2.3509 (0.9); 2.3324 (0.6); 2.3276 (0.6); 2.2742 (16.0); 2.2522 (1.1); 2.2408 (1.3); 2.2280 (1.5); 2.2106 (0.6); 2.1990 (0.8); 2.1865 (0.8); 2.1312 (0.5); 2.1123 (0.8); 2.0922 (1.4); 2.0874 (1.3); 2.0729 (1.0); 2.0648 (1.0); 2.0550 (1.1); 2.0452 (1.0); 1.6554 (0.7); 1.6346 (1.6); 1.6240 (1.6); 1.6129 (1.5); 1.6006 (1.6); 1.5927 (1.6); 1.5830 (1.3); 1.5691 (1.2); 1.5377 (0.9); 1.5277 (0.6); 1.5029 (0.5); 1.4921 (0.5); 1.2430 (3.0); 1.2253 (6.4); 1.2178 (2.6); 1.2075 (3.7); 1.2001 (5.5); 1.1905 (4.5); 1.1862 (2.9); 1.1823 (3.3); 1.1729 (10.3); 1.1685 (4.4); 1.1558 (9.8); 1.1509 (2.3); 1.1382 (3.8); -0.0002 (7.6) I.1-367: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.2132 (1.0); 8.1942 (1.0); 7.1773 (0.7); 7.1704 (0.5); 7.1568 (2.4); 7.1495 (0.9); 7.1391 (2.4); 7.1185 (0.7); 7.1101 (0.6); 6.9512 (1.0); 6.9322 (1.0); 4.7072 (0.6); 4.6691 (0.6); 4.0642 (0.6); 4.0583 (0.9); 3.9375 (2.1); 3.3166 (4.3); 3.1608 (16.0); 3.1228 (1.4); 3.1045 (4.6); 3.0863 (4.7); 3.0681 (1.4); 2.9165 (4.6); 2.7642 (2.0); 2.6699 (0.6); 2.6651 (0.6); 2.6045 (0.5); 2.5851 (1.4); 2.5663 (1.2); 2.5451 (0.5); 2.5233 (1.5); 2.5186 (2.2); 2.5100 (27.5); 2.5054 (59.0); 2.5008 (81.8); 2.4962 (57.2); 2.4916 (25.3); 2.4679 (0.6); 2.4548 (0.6); 2.4501 (1.0); 2.4456 (1.2); 2.4409 (0.7); 2.3276 (0.7); 1.1919 (5.0); 1.1830 (2.0); 1.1787 (2.1); 1.1737 (10.8); 1.1641 (4.0); 1.1598 (4.0); 1.1554 (5.0); 1.1451 (1.7); 1.1408 (1.7); 0.0080 (1.4); -0.0002 (43.6); -0.0085 (1.2); -0.0507 (0.5) I.1-368: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.4192 (1.8); 7.4014 (4.6); 7.3828 (3.9); 7.3560 (1.6); 7.3394 (1.5); 7.1810 (8.6); 7.1773 (12.9); 7.1721 (5.7); 7.1598 (13.0); 7.1570 (16.0); 7.1430 (1.7); 7.1296 (1.5); 7.1241 (1.5); 7.1112 (1.9); 6.9189 (1.5); 6.9024 (1.3); 4.5229 (1.2); 4.4835 (1.3); 4.0986 (0.6); 4.0589 (0.5); 3.9052 (1.4); 3.8662 (1.2); 3.7476 (1.3); 3.7376 (1.5); 3.7286 (1.3); 3.0944 (9.2); 2.5236 (0.8); 2.5188 (1.1); 2.5102 (15.9); 2.5056 (34.6); 2.5010 (48.4); 2.4964 (34.3); 2.4918 (15.6); 2.4045 (1.0); 2.3661 (1.1); 2.3279 (0.5); 2.2610 (1.2); 2.2230 (3.4); 2.2109 (2.6); 2.1587 (13.1); 2.1216 (1.4); 2.1108 (1.6); 2.0909 (1.6); 2.0730 (2.2); 2.0381 (0.7); 1.6701 (1.0); -0.0002 (15.4) I.1-369: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 9.9728 (8.7); 7.5405 (10.7); 7.5377 (13.4); 7.5329 (4.1); 7.5188 (15.3); 7.5163 (13.5); 7.3672 (1.5); 7.3632 (1.6); 7.3467 (3.1); 7.3426 (3.5); 7.3366 (1.9); 7.3270 (2.3); 7.3207 (3.6); 7.3165 (3.3); 7.3089 (2.2); 7.3044 (12.7); 7.2995 (5.3); 7.2857 (16.0); 7.2835 (13.3); 7.2690 (4.2); 7.2645 (12.0); 7.2595 (1.5); 7.2069 (1.9); 7.2030 (2.0); 7.1942 (1.9); 7.1903 (2.3); 7.1870 (3.6); 7.1833 (3.8); 7.1742 (3.5); 7.1709 (3.9); 7.1666 (2.4); 7.1628 (2.3); 7.1538 (2.0); 7.1504 (2.2); 7.1247 (0.5); 7.0986 (3.6); 7.0826 (4.8); 7.0631 (2.7); 7.0569 (3.8); 7.0540 (6.0); 7.0511 (3.5); 7.0355 (9.6); 7.0199 (2.6); 7.0171 (4.4); 7.0142 (2.4); 4.7617 (5.5); 4.7220 (6.4); 4.2976 (7.0); 4.2577 (5.9); 3.9367 (1.1); 3.9255 (2.4); 3.9154 (3.2); 3.9052 (4.2); 3.8954 (3.2); 3.8852 (2.4); 3.8743 (1.1); 3.3566 (0.6); 3.3226 (130.9); 3.1676 (0.9); 2.7690 (4.9); 2.7574 (5.0); 2.7327 (6.1); 2.7211 (5.9); 2.6752 (0.8); 2.6705 (1.1); 2.6658 (0.8); 2.5448 (0.7); 2.5407 (1.2); 2.5356 (0.9); 2.5307 (0.8); 2.5240 (2.6); 2.5193 (4.1); 2.5106 (58.5); 2.5060 (126.9); 2.5014 (176.7); 2.4968 (123.5); 2.4922 (54.7); 2.4742 (0.9); 2.4643 (6.0); 2.4431 (6.2); 2.4281 (6.3); 2.4069 (8.7); 2.3879 (3.6); 2.3841 (3.3); 2.3655 (2.9); 2.3328 (1.0); 2.3280 (1.7); 2.3239 (3.5); 2.3110 (3.4); 2.3001 (4.6); 2.2871 (4.5); 2.2827 (1.9); 2.2700 (1.1); 2.2583 (2.6); 2.2462 (2.8); 2.2323 (2.1); 2.2139 (3.1); 2.2086 (1.4); 2.2018 (2.3); 2.1949 (1.9); 2.1898 (2.2); 2.1828 (3.6); 2.1778 (2.0); 2.1710 (1.2); 2.1633 (2.0); 2.1586 (2.5); 2.1393 (1.1); 2.0736 (2.2); 1.8493 (1.4); 1.8381 (2.3); 1.8269 (3.0); 1.8167 (2.5); 1.8073 (2.7); 1.7956 (2.6); 1.7844 (1.7); 1.7717 (1.1); 0.0079 (0.6); -0.0002 (21.0); -0.0085 (0.6) I.1-370: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.2326 (0.8); 7.2139 (1.8); 7.2083 (0.9); 7.1952 (1.1); 7.1895 (0.6); 7.0805 (1.4); 7.0614 (1.1); 7.0277 (1.6); 7.0162 (1.0); 6.9972 (1.4); 4.7011 (1.0); 4.6839 (0.5); 4.6629 (1.2); 4.6455 (0.5); 4.1772 (2.4); 4.0732 (1.2); 4.0333 (7.0); 4.0056 (0.6); 3.9673 (0.5); 3.7694 (1.1); 3.7568 (1.4); 3.7470 (1.7); 3.7370 (1.8); 3.7272 (1.6); 3.6884 (0.8); 3.6696 (7.6); 3.6168 (16.0); 2.9361 (14.5); 2.8063 (0.6); 2.7967 (0.7); 2.7660 (6.1); 2.7566 (0.9); 2.5232 (1.0); 2.5185 (1.4); 2.5099 (21.0); 2.5053 (45.7); 2.5007 (63.5); 2.4961 (44.5); 2.4916 (20.3); 2.4699 (1.1); 2.4527 (0.9); 2.4295 (0.9); 2.4060 (0.6); 2.3276 (0.6); 2.2858 (12.7); 2.2650 (0.6); 2.2529 (0.7); 2.2406 (0.7); 2.1257 (0.5); 2.0935 (0.6); -0.0002 (7.9) I.1-371: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 12.5439 (0.9); 8.2863 (1.7); 8.2662 (1.7); 7.2246 (1.6); 7.2209 (2.0); 7.2133 (3.2); 7.2098 (5.0); 7.2070 (6.6); 7.1950 (1.0); 7.1772 (1.2); 7.1704 (1.1); 7.1584 (1.9); 7.1510 (1.8); 7.1445 (1.2); 7.1368 (1.2); 7.1148 (2.6); 7.0968 (1.4); 4.7613 (2.3); 4.7220 (2.5); 4.2514 (0.6); 4.2367 (0.8); 4.2304 (0.9); 4.2168 (1.0); 4.2077 (0.7); 4.1931 (0.7); 4.0911 (2.1); 4.0518 (1.9); 3.7082 (0.5); 3.6963 (0.8); 3.6868 (1.0); 3.6771 (0.9); 3.6662 (0.6); 3.3163 (112.8); 3.2937 (12.0); 2.6791 (0.6); 2.6744 (1.2); 2.6698 (1.7); 2.6651 (1.2); 2.6274 (1.1); 2.6088 (3.2); 2.5902 (3.5); 2.5716 (1.5); 2.5400 (1.1); 2.5233 (4.5); 2.5186 (6.6); 2.5099 (91.1); 2.5053 (199.1); 2.5007 (277.2); 2.4961 (194.8); 2.4915 (86.8); 2.4701 (2.0); 2.4555 (0.9); 2.4506 (0.9); 2.4321 (0.6); 2.4094 (1.0); 2.3890 (1.0); 2.3674 (1.4); 2.3448 (0.8); 2.3368 (0.7); 2.3321 (1.3); 2.3275 (1.7); 2.3229 (1.3); 2.2908 (1.7); 2.2834 (1.0); 2.2693 (1.9); 2.2573 (2.0); 2.2482 (1.3); 2.2418 (1.2); 2.2350 (1.4); 2.2164 (0.8); 2.2062 (0.8); 2.0852 (1.3); 2.0731 (1.7); 2.0665 (0.7); 2.0558 (0.6); 2.0483 (1.0); 2.0341 (0.9); 2.0109 (0.8); 1.7879 (0.6); 1.7737 (0.6); 1.7648 (0.9); 1.7546 (0.9); 1.6219 (0.6); 1.6013 (0.7); 1.5861 (0.7); 1.5123 (1.4); 1.5013 (2.0); 1.4876 (2.4); 1.4788 (1.5); 1.4653 (1.2); 1.1557 (0.6); 1.1419 (6.8); 1.1232 (16.0); 1.1043 (6.6); 0.8912 (9.9); 0.8748 (9.6); 0.8232 (10.0); 0.8069 (9.7); 0.0119 (0.6); 0.0111 (0.7); 0.0103 (0.8); 0.0080 (5.0); 0.0064 (1.6); 0.0055 (1.8); 0.0047 (2.2); 0.0038 (3.0); -0.0002 (156.6); -0.0059 (1.6); -0.0067 (1.4); -0.0085 (4.4); -0.0107 (0.8); -0.0114 (0.7); -0.1496 (0.5) I.1-372: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.0190 (4.2); 8.0107 (4.1); 7.3768 (1.6); 7.3555 (3.4); 7.3353 (3.5); 7.3136 (1.8); 7.2048 (2.1); 7.1887 (3.4); 7.1851 (3.6); 7.1725 (3.7); 7.1522 (1.7); 7.0668 (3.4); 7.0512 (4.6); 7.0316 (2.5); 4.7196 (5.5); 4.6795 (6.3); 4.5964 (1.8); 4.2215 (7.1); 4.1818 (6.1); 4.0942 (1.0); 4.0309 (1.0); 3.9862 (1.0); 3.8929 (1.0); 3.8003 (2.4); 3.7911 (3.8); 3.7806 (4.6); 3.7702 (3.3); 3.7593 (2.7); 3.6865 (1.2); 3.5959 (3.2); 3.5560 (2.5); 3.5425 (2.1); 3.5259 (5.2); 3.5014 (2.1); 3.4917 (8.8); 3.4842 (9.0); 3.4456 (111.1); 3.4280 (96.8); 3.3529 (39.9); 3.3315 (6.4); 3.3131 (7.5); 3.2917 (13.7); 3.2753 (18.0); 3.2549 (3.8); 3.2479 (4.7); 3.1952 (5.0); 3.1853 (3.0); 3.1696 (16.0); 3.1419 (1.6); 3.0478 (0.9); 2.8950 (0.9); 2.7713 (2.1); 2.7590 (1.5); 2.6780 (5.8); 2.6734 (8.2); 2.6688 (6.0); 2.5906 (1.9); 2.5808 (2.7); 2.5723 (5.5); 2.5624 (9.0); 2.5595 (9.7); 2.5548 (11.9); 2.5504 (5.3); 2.5433 (5.4); 2.5377 (5.8); 2.5334 (5.9); 2.5267 (19.1); 2.5220 (28.5); 2.5134 (461.3); 2.5088 (1013.8); 2.5042 (1430.8); 2.4996 (1017.2); 2.4950 (462.7); 2.4676 (3.4); 2.4605 (3.6); 2.4568 (3.3); 2.4459 (1.9); 2.4224 (6.9); 2.4106 (6.3); 2.3923 (3.1); 2.3689 (2.2); 2.3504 (4.6); 2.3402 (3.6); 2.3356 (7.2); 2.3310 (12.5); 2.3265 (9.4); 2.3079 (3.7); 2.2841 (3.3); 2.2706 (3.6); 2.2599 (4.9); 2.2470 (4.4); 2.2286 (1.9); 2.2181 (2.4); 2.2050 (2.6); 2.1468 (6.6); 2.1257 (7.8); 2.1181 (3.0); 2.1115 (6.6); 2.0984 (3.7); 2.0905 (5.7); 2.0717 (4.9); 2.0555 (1.4); 1.7468 (1.4); 1.7345 (2.2); 1.7237 (3.0); 1.7105 (2.4); 1.7019 (2.5); 1.6917 (2.8); 1.6809 (1.7); 1.6677 (1.4); 1.1413 (1.0); 1.0689 (1.0); 1.0507 (1.7); 1.0303 (2.2); 0.6097 (3.2); 0.5973 (8.5); 0.5925 (11.0); 0.5804 (10.8); 0.5746 (9.4); 0.5630 (4.3); 0.3484 (3.7); 0.3376 (10.8); 0.3311 (8.9); 0.3276 (9.6); 0.3219 (9.2); 0.3107 (3.4); 0.1460 (1.2); 0.0503 (2.1); 0.0080 (8.6); -0.0002 (340.1); -0.0085 (11.2); -0.0486 (0.9); -0.1497 (1.1) I.1-373: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.0075 (1.3); 7.2288 (1.4); 7.2099 (3.2); 7.1912 (2.0); 7.0792 (1.9); 7.0591 (1.4); 7.0154 (2.9); 7.0027 (1.8); 6.9821 (1.3); 4.6598 (2.1); 4.6215 (2.3); 4.0119 (2.2); 3.9732 (2.0); 3.7250 (0.9); 3.7141 (1.1); 3.3164 (183.3); 3.1923 (0.8); 2.7808 (1.8); 2.6744 (1.9); 2.6696 (2.7); 2.6653 (1.8); 2.6002 (1.1); 2.5910 (0.9); 2.5820 (1.6); 2.5722 (1.9); 2.5629 (1.4); 2.5539 (1.5); 2.5384 (2.6); 2.5339 (4.0); 2.5291 (4.5); 2.5233 (8.8); 2.5185 (12.2); 2.5099 (160.8); 2.5053 (346.8); 2.5007 (479.5); 2.4961 (331.8); 2.4915 (146.3); 2.4557 (2.4); 2.4455 (1.9); 2.4213 (2.0); 2.4099 (2.0); 2.3321 (2.1); 2.3274 (3.0); 2.3226 (2.9); 2.2854 (16.0); 2.2673 (1.2); 2.2569 (1.4); 2.2434 (1.4); 2.2145 (0.7); 2.0770 (1.8); 2.0550 (1.8); 2.0426 (1.8); 2.0201 (1.9); 1.6831 (0.9); 1.6731 (0.8); 1.1752 (1.0); 1.1066 (1.3); 1.0883 (0.7); 0.8280 (0.8); 0.6104 (1.3); 0.5985 (3.1); 0.5936 (3.7); 0.5813 (3.2); 0.5756 (2.8); 0.5644 (1.0); 0.3578 (1.2); 0.3471 (3.3); 0.3405 (3.0); 0.3372 (2.8); 0.3310 (2.7); 0.3211 (0.9); 0.0080 (2.3); -0.0002 (81.5); -0.0086 (2.3) I.1-374: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.1530 (1.0); 8.1492 (0.6); 8.1394 (0.6); 8.1355 (1.0); 7.1851 (0.9); 7.1437 (0.7); 7.1395 (0.6); 6.7515 (1.0); 6.7476 (0.6); 6.7380 (0.6); 6.7340 (0.9); 3.0597 (0.9); 3.0408 (16.0); 3.0233 (2.9); 3.0052 (0.9); 2.5102 (6.6); 2.5057 (14.2); 2.5011 (19.8); 2.4965 (13.9); 2.4919 (6.2); 1.1950 (4.4); 1.1777 (4.4); 1.1695 (3.7); 1.1513 (7.6); 1.1331 (3.4); 0.8479 (1.9); 0.8306 (2.9); 0.8123 (0.6); -0.0002 (8.2) I.1-375: 1 H-NMR (400.0 MHz, CDCl 3 ): δ= 7.5564 (0.5); 7.5203 (2.9); 7.5147 (3.6); 7.4955 (6.1); 7.4556 (4.1); 7.4367 (8.0); 7.4166 (12.5); 7.3808 (6.6); 7.3619 (3.7); 7.3118 (0.8); 7.3013 (0.5); 7.2798 (0.9); 7.2734 (1.3); 7.2726 (1.4); 7.2710 (1.8); 7.2702 (1.9); 7.2686 (2.7); 7.2678 (3.1); 7.2615 (294.4); 7.2573 (3.3); 7.2564 (2.0); 7.2556 (1.4); 7.2548 (0.8); 7.2540 (0.6); 7.2532 (0.6); 7.1258 (1.1); 7.1163 (1.7); 7.1098 (1.6); 7.1010 (4.0); 7.0884 (3.0); 7.0860 (2.8); 7.0823 (3.2); 7.0756 (4.0); 7.0661 (2.0); 7.0621 (2.4); 7.0580 (4.6); 7.0543 (8.4); 7.0468 (12.5); 7.0442 (7.7); 7.0381 (10.8); 7.0310 (4.2); 7.0276 (5.9); 7.0160 (1.0); 7.0097 (0.7); 6.9974 (1.6); 5.4611 (2.5); 4.8482 (5.3); 4.8445 (5.1); 4.8095 (6.0); 4.8058 (5.8); 4.2384 (7.4); 4.1997 (6.6); 3.9526 (1.2); 3.9416 (2.5); 3.9308 (3.2); 3.9203 (3.6); 3.9105 (3.2); 3.8996 (2.6); 3.8885 (1.3); 3.5985 (0.8); 3.5808 (1.9); 3.5646 (3.4); 3.5467 (5.9); 3.5316 (7.1); 3.5144 (6.8); 3.4997 (5.4); 3.4825 (3.3); 3.4656 (1.7); 3.4484 (0.8); 2.9086 (0.5); 2.8906 (8.7); 2.8730 (16.0); 2.8554 (7.1); 2.6016 (5.3); 2.5908 (5.3); 2.5654 (6.2); 2.5546 (6.0); 2.5311 (1.1); 2.5120 (1.4); 2.5089 (1.3); 2.4886 (3.8); 2.4691 (3.6); 2.4657 (3.4); 2.4458 (3.4); 2.4375 (3.9); 2.4228 (4.5); 2.4133 (5.2); 2.3988 (5.3); 2.3945 (1.9); 2.3797 (1.5); 2.3701 (2.2); 2.3557 (2.1); 2.2713 (1.9); 2.2521 (3.0); 2.2474 (1.9); 2.2385 (2.4); 2.2330 (2.0); 2.2280 (2.6); 2.2195 (3.4); 2.2144 (2.2); 2.2091 (1.5); 2.2002 (2.1); 2.1951 (2.6); 2.1761 (1.4); 2.1393 (6.7); 2.1170 (6.5); 2.1031 (5.9); 2.0808 (5.7); 2.0067 (1.1); 1.8070 (1.7); 1.7956 (1.9); 1.7927 (2.2); 1.7816 (2.4); 1.7722 (2.5); 1.7689 (2.1); 1.7627 (1.9); 1.7595 (2.5); 1.7484 (2.2); 1.7393 (1.7); 1.7361 (1.5); 1.7246 (1.3); 0.0079 (2.9); 0.0062 (1.0); -0.0002 (96.0); -0.0061 (0.7); -0.0069 (0.6); -0.0085 (2.6) I.1-376: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.2689 (0.6); 8.2555 (1.2); 8.2411 (0.6); 7.3663 (0.8); 7.3443 (0.8); 7.1964 (0.8); 7.1928 (0.9); 7.1804 (0.9); 7.1724 (0.6); 7.1601 (0.5); 7.0780 (1.0); 7.0617 (1.2); 7.0427 (0.6); 4.7388 (1.3); 4.6990 (1.5); 4.2424 (1.6); 4.2027 (1.4); 3.8203 (0.5); 3.8098 (0.7); 3.8001 (0.9); 3.7900 (0.8); 3.7797 (0.6); 3.3844 (0.9); 3.3674 (2.2); 3.3329 (82.6); 3.2829 (0.9); 3.1617 (2.1); 3.1496 (2.4); 3.1441 (2.4); 3.1327 (2.2); 3.1149 (0.9); 3.0926 (0.9); 3.0766 (1.6); 3.0639 (1.7); 2.7819 (0.7); 2.6704 (0.5); 2.5621 (1.2); 2.5509 (1.0); 2.5241 (1.5); 2.5192 (1.8); 2.5105 (30.0); 2.5060 (66.1); 2.5013 (93.4); 2.4967 (65.1); 2.4921 (29.0); 2.4555 (0.5); 2.4509 (0.6); 2.3743 (1.0); 2.3555 (0.9); 2.3327 (1.1); 2.3235 (0.5); 2.3061 (0.8); 2.2925 (0.9); 2.2819 (1.2); 2.2683 (1.2); 2.2621 (1.6); 2.2506 (0.5); 2.2404 (1.8); 2.2263 (1.6); 2.2046 (1.1); 2.1575 (0.6); 2.1450 (0.5); 2.1333 (0.6); 2.1258 (0.8); 2.1016 (0.6); 2.0733 (0.9); 1.7658 (0.5); 1.7552 (0.7); 1.7444 (0.6); 1.7339 (0.6); 1.7234 (0.6); 1.1915 (7.2); 1.1734 (16.0); 1.1552 (6.8); 1.1419 (1.1); - 0.0002 (2.7) I.1-377: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.4891 (0.8); 8.4748 (1.6); 8.4603 (0.8); 7.3658 (0.8); 7.3489 (1.0); 7.3441 (1.7); 7.3274 (1.8); 7.3224 (1.0); 7.3056 (1.0); 7.2441 (1.2); 7.2377 (1.2); 7.2206 (1.3); 7.2179 (1.4); 7.2142 (1.4); 7.2115 (1.4); 7.1944 (1.2); 7.1880 (1.2); 7.1361 (2.7); 7.1162 (6.6); 7.0911 (7.5); 7.0706 (3.5); 7.0555 (1.6); 7.0529 (1.6); 7.0489 (1.4); 7.0466 (1.4); 7.0342 (0.7); 7.0315 (0.8); 7.0275 (0.6); 7.0251 (0.6); 4.6602 (2.0); 4.6223 (2.2); 4.2452 (3.6); 4.2311 (3.5); 3.9880 (2.3); 3.9498 (2.0); 3.7239 (0.8); 3.7130 (1.0); 3.7021 (1.2); 3.6927 (1.1); 3.6820 (0.9); 3.6710 (0.6); 3.6067 (1.5); 2.5755 (1.3); 2.5645 (1.3); 2.5406 (1.8); 2.5297 (1.8); 2.5251 (1.0); 2.5203 (1.3); 2.5115 (16.6); 2.5069 (36.2); 2.5023 (50.4); 2.4977 (35.2); 2.4932 (15.5); 2.3330 (1.3); 2.3136 (1.1); 2.2909 (1.0); 2.2725 (16.0); 2.2503 (1.2); 2.2400 (1.3); 2.2263 (1.3); 2.2084 (0.6); 2.1950 (1.8); 2.1846 (0.7); 2.1724 (1.7); 2.1600 (1.5); 2.1375 (1.4); 2.0414 (0.8); 2.0369 (0.6); 2.0288 (0.6); 2.0222 (0.5); 2.0173 (0.7); 2.0098 (1.0); 2.0051 (0.6); 1.9901 (0.6); 1.9856 (0.8); 1.7014 (0.6); 1.6909 (0.9); 1.6806 (0.7); 1.6693 (0.7); 1.6588 (0.7); -0.0002 (15.7) I.1-378: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 10.4685 (1.8); 10.4643 (1.8); 8.0451 (0.8); 8.0308 (1.7); 8.0163 (0.8); 7.1423 (2.3); 7.1221 (7.5); 7.1181 (6.0); 7.1052 (8.3); 7.0965 (4.8); 7.0955 (4.8); 7.0846 (2.4); 7.0112 (3.0); 7.0056 (2.9); 6.8073 (3.5); 6.8015 (3.7); 6.5917 (2.5); 6.5860 (2.3); 6.5702 (2.3); 6.5644 (2.2); 4.6693 (1.9); 4.6312 (2.1); 4.0078 (2.2); 3.9697 (2.0); 3.7244 (0.8); 3.7134 (1.0); 3.7027 (1.2); 3.6932 (1.1); 3.6822 (0.9); 3.6716 (0.6); 3.5741 (2.3); 3.5187 (14.0); 3.3003 (1.0); 3.2831 (1.9); 3.2664 (1.9); 3.2490 (1.2); 3.1681 (1.0); 2.7098 (1.9); 2.6906 (2.9); 2.6732 (1.9); 2.6656 (0.7); 2.5235 (1.4); 2.5187 (2.3); 2.5101 (35.0); 2.5055 (77.3); 2.5009 (107.4); 2.4963 (75.4); 2.4917 (33.8); 2.4810 (2.2); 2.4698 (1.8); 2.3593 (0.5); 2.3555 (0.6); 2.3366 (1.4); 2.3277 (0.8); 2.3230 (0.7); 2.3179 (1.2); 2.2940 (0.9); 2.2748 (16.0); 2.2573 (1.0); 2.2436 (1.1); 2.2332 (1.3); 2.2195 (1.2); 2.2017 (0.6); 2.1914 (0.7); 2.1777 (0.6); 2.1261 (1.5); 2.1035 (1.5); 2.0915 (1.3); 2.0727 (2.7); 2.0690 (1.4); 2.0304 (0.7); 2.0181 (0.6); 2.0112 (0.5); 2.0062 (0.7); 1.9987 (0.9); 1.9941 (0.6); 1.9793 (0.6); 1.9746 (0.7); 1.6903 (0.6); 1.6795 (0.8); 1.6693 (0.7); 1.6579 (0.7); 1.6475 (0.7); -0.0002 (6.8) I.1-379: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.9122 (1.5); 8.8909 (1.6); 7.3450 (1.7); 7.3402 (2.2); 7.3259 (4.0); 7.3236 (4.0); 7.3215 (4.1); 7.3190 (3.5); 7.3082 (3.9); 7.3034 (4.5); 7.2594 (2.5); 7.2498 (8.5); 7.2428 (3.7); 7.2340 (5.6); 7.2297 (4.8); 7.2213 (1.0); 7.2173 (0.8); 7.1693 (0.5); 7.1637 (1.7); 7.1593 (1.8); 7.1546 (5.9); 7.1512 (6.9); 7.1436 (1.2); 7.1346 (1.6); 7.1244 (1.3); 7.1121 (0.6); 7.0914 (1.8); 7.0760 (1.1); 6.1043 (1.9); 6.0830 (1.8); 4.6928 (1.7); 4.6534 (1.9); 4.0259 (1.8); 3.9866 (1.6); 3.7134 (0.7); 3.7027 (0.9); 3.6918 (0.7); 3.3537 (33.4); 2.6742 (0.7); 2.6696 (1.0); 2.6650 (0.7); 2.6446 (1.0); 2.6339 (1.0); 2.6097 (1.3); 2.5993 (1.4); 2.5230 (3.0); 2.5183 (4.4); 2.5097 (56.2); 2.5051 (120.0); 2.5005 (166.7); 2.4959 (116.6); 2.4914 (51.9); 2.4550 (0.8); 2.4506 (0.8); 2.4459 (0.6); 2.3876 (0.7); 2.3733 (1.4); 2.3677 (1.0); 2.3507 (1.6); 2.3456 (1.5); 2.3386 (1.4); 2.3319 (1.0); 2.3272 (1.4); 2.3227 (1.5); 2.3164 (1.2); 2.2879 (0.7); 2.2765 (0.8); 2.2637 (1.1); 2.2524 (1.0); 2.2217 (0.6); 2.2106 (0.5); 2.1829 (16.0); 2.0852 (0.6); 2.0733 (0.6); 2.0618 (0.6); 2.0531 (0.8); 2.0301 (0.6); 1.7790 (0.5); 1.7575 (0.7); 1.7466 (0.7); 0.0080 (1.0); -0.0002 (33.6); - 0.0085 (0.9) I.1-380: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 7.1541 (4.6); 7.1412 (2.7); 3.4508 (16.0); 3.2086 (1.9); 3.1672 (5.4); 2.7569 (2.0); 2.6697 (4.4); 2.5866 (3.4); 2.5673 (4.5); 2.5392 (6.3); 2.5347 (7.1); 2.5298 (6.3); 2.5231 (13.3); 2.5183 (20.0); 2.5097 (267.7); 2.5052 (569.6); 2.5006 (783.0); 2.4960 (547.4); 2.4915 (245.6); 2.3273 (4.9); 2.0732 (1.5); 1.1827 (3.0); 1.1637 (6.2); 1.1445 (3.7); 0.8481 (4.4); 0.8305 (5.7); 0.0080 (6.9); -0.0002 (264.6); -0.0085 (9.0); -0.1496 (1.3) I.1-381: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.2396 (0.5); 8.2262 (1.0); 8.2127 (0.5); 7.5640 (4.2); 7.2896 (4.4); 7.2881 (4.4); 7.1391 (1.8); 7.1191 (5.1); 7.0984 (5.7); 7.0779 (1.8); 4.6597 (1.4); 4.6216 (1.6); 4.0839 (1.9); 4.0656 (9.2); 4.0509 (4.1); 4.0476 (7.0); 4.0294 (2.0); 3.9861 (1.7); 3.9481 (1.6); 3.7882 (1.2); 3.7384 (0.6); 3.7276 (0.8); 3.7167 (1.0); 3.7061 (1.0); 3.6964 (0.9); 3.6856 (0.7); 2.5167 (1.4); 2.5102 (7.3); 2.5056 (16.4); 2.5010 (21.7); 2.4963 (15.0); 2.4918 (6.6); 2.4823 (1.3); 2.4712 (1.2); 2.3326 (0.9); 2.3134 (0.8); 2.2901 (0.8); 2.2742 (11.9); 2.2596 (0.8); 2.2460 (0.9); 2.2355 (1.0); 2.2220 (1.0); 2.1936 (0.5); 2.1468 (1.3); 2.1244 (1.3); 2.1122 (1.2); 2.0898 (1.1); 2.0457 (0.6); 2.0215 (0.6); 2.0140 (0.7); 1.9898 (0.6); 1.6967 (0.7); 1.6865 (0.5); 1.6751 (0.5); 1.6647 (0.6); 1.3340 (7.2); 1.3158 (16.0); 1.2976 (7.1); -0.0002 (1.8) I.1-382: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.2616 (0.6); 8.2474 (1.2); 8.2336 (0.6); 7.1503 (2.1); 7.1303 (6.0); 7.1100 (6.9); 7.0895 (2.2); 4.6680 (1.7); 4.6297 (1.8); 4.0313 (1.9); 3.9930 (1.7); 3.7401 (0.6); 3.7291 (0.8); 3.7180 (0.9); 3.7087 (0.8); 3.6979 (0.6); 3.3842 (0.8); 3.3680 (2.1); 3.3520 (2.6); 3.3290 (44.3); 3.1851 (0.6); 3.1560 (2.0); 3.1460 (2.4); 3.1287 (2.2); 3.0714 (1.5); 3.0592 (1.5); 3.0436 (0.7); 2.5498 (1.2); 2.5391 (1.2); 2.5236 (1.0); 2.5188 (1.6); 2.5102 (22.6); 2.5056 (49.4); 2.5010 (69.1); 2.4964 (48.3); 2.4918 (21.5); 2.3607 (1.0); 2.3419 (0.9); 2.3374 (1.0); 2.3278 (0.6); 2.3187 (0.9); 2.2909 (1.0); 2.2784 (14.4); 2.2670 (1.4); 2.2530 (1.2); 2.2250 (0.6); 2.2112 (0.6); 2.1780 (1.4); 2.1554 (1.4); 2.1425 (1.2); 2.1198 (1.3); 2.0835 (0.6); 2.0710 (0.5); 2.0594 (0.6); 2.0521 (0.8); 2.0470 (0.5); 2.0278 (0.6); 1.7189 (0.5); 1.7081 (0.7); 1.6976 (0.6); 1.6866 (0.6); 1.6759 (0.6); 1.1869 (7.2); 1.1688 (16.0); 1.1506 (6.9); -0.0002 (13.6); -0.0028 (0.7) I.1-383: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 9.1745 (0.5); 7.2333 (1.6); 7.2152 (2.9); 7.1961 (1.7); 7.0881 (2.0); 7.0687 (1.5); 7.0136 (4.3); 6.9921 (1.4); 4.6549 (1.7); 4.6166 (2.0); 4.0776 (1.9); 4.0386 (2.0); 3.8293 (1.8); 3.6033 (7.0); 3.5848 (6.8); 3.2132 (2.1); 3.1870 (1.3); 3.1672 (9.0); 3.1520 (2.6); 3.1376 (2.2); 3.1210 (1.1); 3.1089 (1.2); 3.0373 (1.1); 3.0254 (2.6); 2.9999 (2.2); 2.9588 (1.2); 2.9504 (1.1); 2.7659 (14.8); 2.7535 (14.4); 2.6790 (1.8); 2.6743 (3.7); 2.6697 (5.3); 2.6651 (3.9); 2.6435 (0.9); 2.5371 (2.6); 2.5321 (5.6); 2.5232 (17.4); 2.5185 (23.4); 2.5098 (273.0); 2.5053 (582.8); 2.5007 (807.5); 2.4961 (563.2); 2.4915 (248.7); 2.4662 (2.2); 2.4554 (4.0); 2.4506 (4.1); 2.4141 (1.6); 2.3948 (1.8); 2.3723 (0.8); 2.3321 (3.8); 2.3274 (5.2); 2.3228 (3.9); 2.3182 (2.1); 2.2931 (7.0); 2.2836 (16.0); 2.2479 (1.1); 2.1765 (1.0); 2.1440 (1.0); 2.1229 (0.8); 2.0732 (2.4); 1.7974 (1.2); 1.7764 (1.4); 1.7388 (0.8); 1.6943 (0.9); 1.6840 (0.8); 1.1853 (1.1); 1.0708 (5.6); 1.0528 (12.5); 1.0348 (5.4); 0.1460 (1.2); 0.0324 (0.9); 0.0080 (10.0); -0.0002 (334.8); -0.0085 (9.6); -0.0344 (1.1); -0.0504 (1.0); -0.1496 (1.2) I.1-384: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.0053 (1.0); 7.9959 (1.0); 7.1758 (1.9); 7.1677 (8.0); 7.1629 (4.1); 7.1585 (1.2); 7.1513 (1.6); 7.1455 (0.6); 7.1387 (1.0); 7.0821 (1.4); 7.0699 (1.3); 7.0628 (0.6); 4.6886 (1.7); 4.6490 (1.9); 4.0323 (1.7); 3.9928 (1.6); 3.6967 (0.7); 3.6858 (0.9); 3.6751 (0.8); 3.3258 (7.9); 3.1848 (1.0); 3.1156 (0.5); 3.1039 (0.5); 3.0972 (0.5); 3.0859 (0.5); 2.5914 (0.6); 2.5817 (0.8); 2.5732 (1.2); 2.5634 (1.3); 2.5551 (0.8); 2.5453 (0.6); 2.5232 (0.5); 2.5185 (0.8); 2.5098 (12.2); 2.5053 (26.6); 2.5007 (36.9); 2.4961 (25.8); 2.4915 (11.6); 2.4418 (1.2); 2.4308 (1.1); 2.4070 (1.6); 2.3960 (1.3); 2.3860 (0.7); 2.3652 (0.8); 2.3442 (1.2); 2.3225 (0.8); 2.2955 (0.8); 2.2839 (1.0); 2.2714 (1.1); 2.2599 (1.0); 2.2420 (0.8); 2.2287 (16.0); 2.2184 (0.7); 2.1225 (1.5); 2.1079 (0.7); 2.1000 (1.6); 2.0876 (1.6); 2.0760 (0.8); 2.0731 (0.8); 2.0652 (1.3); 2.0526 (0.6); 1.7136 (0.8); 1.7024 (0.7); 1.1934 (1.7); 1.1752 (3.7); 1.1570 (1.7); 0.6043 (0.9); 0.5923 (2.2); 0.5870 (2.9); 0.5748 (2.8); 0.5692 (2.4); 0.5574 (1.0); 0.3484 (1.1); 0.3372 (2.6); 0.3319 (2.4); 0.3271 (2.3); 0.3220 (2.4); 0.3101 (0.9); -0.0002 (15.4) I.1-385: 1 H-NMR (400.0 MHz, CDCl3): δ= 7.2614 (11.3); 7.1099 (8.7); 6.3376 (0.9); 6.3320 (0.7); 6.3061 (2.2); 6.3005 (1.6); 4.7115 (0.6); 4.6740 (0.6); 4.1104 (0.6); 4.0729 (0.5); 3.7717 (16.0); 2.7192 (0.6); 2.7020 (1.2); 2.6848 (0.5); 2.4502 (0.7); 2.3200 (4.9); -0.0002 (3.1) I.1-387: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.2276 (2.3); 7.2237 (2.7); 7.2141 (6.4); 7.2105 (5.7); 7.2048 (2.1); 7.1784 (1.2); 7.1714 (0.8); 7.1647 (1.8); 7.1580 (2.3); 7.1516 (1.8); 7.1447 (2.0); 7.1386 (3.0); 7.1185 (1.4); 7.0991 (0.5); 7.0770 (0.7); 5.0488 (1.4); 5.0345 (1.4); 4.8145 (1.3); 4.7999 (0.8); 4.7748 (2.5); 4.7663 (1.0); 4.7353 (1.8); 4.2880 (0.6); 4.2547 (0.6); 4.1695 (1.0); 4.1517 (1.3); 4.1358 (2.1); 4.1150 (3.0); 4.1057 (2.9); 4.1024 (3.0); 4.0972 (3.3); 4.0896 (4.3); 4.0848 (2.8); 4.0790 (1.8); 4.0720 (4.4); 4.0544 (1.2); 4.0447 (0.7); 4.0304 (0.7); 4.0062 (0.6); 3.7082 (1.2); 3.6845 (1.3); 3.3773 (33.3); 3.1659 (0.7); 3.0069 (0.6); 2.9840 (0.5); 2.9607 (0.6); 2.8572 (0.8); 2.8170 (0.9); 2.7905 (0.5); 2.7809 (0.6); 2.7504 (0.7); 2.7414 (0.6); 2.6697 (1.2); 2.6652 (0.8); 2.6183 (1.4); 2.5994 (4.4); 2.5933 (2.2); 2.5808 (4.6); 2.5749 (3.0); 2.5624 (1.9); 2.5560 (2.7); 2.5469 (1.0); 2.5400 (1.2); 2.5232 (3.4); 2.5186 (4.2); 2.5099 (66.9); 2.5053 (147.4); 2.5007 (206.9); 2.4961 (145.1); 2.4914 (64.4); 2.4596 (1.7); 2.4356 (1.9); 2.4122 (1.3); 2.3964 (1.2); 2.3738 (0.7); 2.3529 (0.7); 2.3321 (1.1); 2.3275 (1.2); 2.3227 (1.0); 2.2787 (1.0); 2.2688 (1.0); 2.2627 (0.8); 2.2546 (1.4); 2.2441 (1.2); 2.2375 (1.3); 2.2129 (0.7); 2.2028 (0.9); 2.1959 (0.7); 2.1459 (0.6); 2.1272 (1.0); 2.0768 (1.6); 2.0474 (1.1); 1.6844 (0.8); 1.5986 (1.5); 1.2184 (3.2); 1.2006 (6.0); 1.1880 (6.4); 1.1828 (4.0); 1.1807 (3.8); 1.1702 (16.0); 1.1628 (6.0); 1.1522 (14.6); 1.1450 (3.5); 1.1388 (6.2); 1.1344 (5.6); 1.1221 (12.1); 1.1201 (12.0); 1.1036 (7.8); 1.0851 (1.8); 0.0119 (0.6); 0.0111 (0.7); 0.0080 (4.9); 0.0063 (1.6); 0.0055 (1.8); 0.0047 (2.2); 0.0039 (2.8); 0.0022 (7.2); -0.0002 (154.3); -0.0027 (8.7); -0.0051 (2.0); -0.0060 (1.5); -0.0068 (1.3); -0.0085 (4.3) I.1-388: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.3036 (1.6); 8.2987 (1.5); 8.2776 (0.7); 8.2726 (0.7); 7.7143 (1.0); 7.7080 (1.0); 7.6938 (1.6); 7.6875 (1.5); 7.6734 (0.5); 7.6672 (0.5); 7.4920 (2.0); 7.4903 (2.2); 7.4714 (1.7); 7.4698 (1.8); 4.6733 (1.0); 4.6342 (1.3); 4.6002 (0.6); 4.2092 (1.2); 4.1941 (2.3); 4.1860 (0.7); 4.1701 (1.0); 4.0410 (6.0); 3.8300 (0.6); 3.8214 (0.8); 3.8119 (0.6); 3.6737 (7.2); 3.6249 (16.0); 3.3996 (70.1); 3.1671 (1.5); 3.0144 (0.7); 2.9640 (14.4); 2.8432 (0.6); 2.8317 (0.6); 2.8026 (0.8); 2.7910 (0.8); 2.7730 (5.0); 2.6747 (1.0); 2.6701 (1.4); 2.6654 (1.0); 2.5605 (0.6); 2.5559 (1.3); 2.5513 (1.7); 2.5465 (1.5); 2.5404 (1.3); 2.5318 (0.6); 2.5235 (4.1); 2.5189 (5.0); 2.5102 (77.1); 2.5056 (169.2); 2.5010 (236.4); 2.4963 (165.7); 2.4917 (73.5); 2.4722 (0.8); 2.4674 (0.9); 2.4626 (0.7); 2.4152 (0.7); 2.3910 (0.6); 2.3819 (0.6); 2.3608 (0.5); 2.3417 (0.6); 2.3324 (1.2); 2.3277 (1.6); 2.3231 (1.2); 2.2525 (0.7); 2.2398 (0.7); 2.2005 (0.6); 2.1929 (0.7); 2.1756 (0.6); 2.1444 (0.6); 1.6346 (0.5); 0.0079 (1.3); 0.0046 (0.5); -0.0002 (49.9); -0.0085 (1.5) I.1-389: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 9.5994 (14.1); 8.6430 (14.2); 8.6273 (16.0); 8.6165 (2.6); 8.2522 (5.8); 8.2321 (6.6); 8.2187 (6.9); 8.2028 (6.4); 7.8746 (4.3); 7.8593 (7.6); 7.8239 (8.6); 7.8037 (8.4); 7.7858 (4.6); 7.3755 (1.4); 7.3715 (1.5); 7.3550 (3.0); 7.3511 (3.2); 7.3451 (1.8); 7.3351 (2.3); 7.3289 (3.1); 7.3248 (2.7); 7.3087 (1.6); 7.3049 (1.6); 7.1952 (1.9); 7.1913 (2.1); 7.1824 (1.9); 7.1787 (2.4); 7.1753 (3.4); 7.1715 (3.7); 7.1624 (3.2); 7.1591 (3.7); 7.1550 (2.3); 7.1510 (2.1); 7.1421 (1.8); 7.1386 (2.0); 7.0662 (3.4); 7.0501 (4.6); 7.0308 (2.3); 4.8187 (2.0); 4.8043 (2.0); 4.7804 (5.0); 4.7659 (5.0); 4.7402 (5.1); 4.7267 (5.3); 4.7146 (5.6); 4.7024 (2.5); 4.6886 (2.4); 4.6750 (6.3); 4.2669 (2.0); 4.2195 (7.8); 4.1799 (7.0); 3.9648 (1.2); 3.8860 (1.1); 3.8516 (1.7); 3.8410 (2.7); 3.8305 (3.6); 3.8203 (4.2); 3.8101 (3.6); 3.7996 (2.7); 3.7890 (1.5); 3.6215 (0.6); 3.6027 (0.9); 3.5859 (0.8); 3.1666 (6.9); 3.1521 (0.6); 3.1341 (0.5); 3.0336 (0.7); 2.7710 (4.2); 2.7600 (3.2); 2.6799 (0.6); 2.6753 (1.3); 2.6707 (2.0); 2.6660 (1.5); 2.6614 (0.6); 2.6301 (3.8); 2.6192 (4.0); 2.5949 (4.6); 2.5839 (4.7); 2.5242 (3.7); 2.5195 (5.8); 2.5108 (103.8); 2.5062 (230.3); 2.5016 (323.4); 2.4970 (228.1); 2.4924 (102.3); 2.4219 (0.6); 2.4054 (0.8); 2.3713 (1.2); 2.3484 (1.6); 2.3286 (5.4); 2.3239 (2.3); 2.3131 (6.8); 2.2916 (6.0); 2.2782 (4.9); 2.2688 (3.2); 2.2560 (6.9); 2.2448 (4.6); 2.2315 (4.3); 2.2138 (1.4); 2.2029 (2.2); 2.1901 (2.2); 2.1517 (1.6); 2.1323 (2.6); 2.1202 (1.9); 2.1130 (1.7); 2.1085 (2.3); 2.1010 (3.1); 2.0965 (2.0); 2.0893 (1.2); 2.0811 (1.8); 2.0770 (2.3); 2.0739 (1.6); 2.0574 (1.0); 1.8103 (0.5); 1.7771 (1.4); 1.7648 (2.1); 1.7538 (2.8); 1.7434 (2.4); 1.7327 (2.4); 1.7220 (2.6); 1.7114 (1.5); 1.6983 (1.1); 1.0684 (1.7); 1.0504 (4.0); 1.0325 (1.8); 0.1460 (0.6); 0.0080 (6.2); -0.0002 (228.7); -0.0086 (6.4); -0.1494 (0.6) I.1-390: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.1681 (3.8); 7.5413 (2.6); 7.4244 (5.1); 7.3955 (8.8); 7.3769 (6.9); 7.3513 (2.8); 7.3337 (2.8); 7.2059 (11.1); 7.2022 (16.0); 7.1848 (10.3); 4.3884 (1.8); 4.3494 (2.7); 4.1620 (2.8); 4.1233 (2.1); 3.8371 (2.3); 3.4475 (3.4); 3.4047 (3.0); 3.3472 (1325.9); 3.2990 (11.7); 3.2298 (1.6); 3.1671 (7.6); 3.1053 (14.8); 2.6746 (7.0); 2.6701 (9.5); 2.6655 (6.6); 2.6060 (2.6); 2.6020 (2.8); 2.5401 (4.6); 2.5234 (27.6); 2.5186 (42.8); 2.5100 (546.6); 2.5055 (1157.8); 2.5009 (1594.9); 2.4963 (1136.1); 2.4918 (519.3); 2.4559 (10.5); 2.4517 (11.0); 2.4117 (3.0); 2.3779 (2.9); 2.3323 (8.0); 2.3277 (10.6); 2.3231 (7.6); 2.2226 (4.1); 2.1741 (2.4); 2.0731 (2.1); 2.0061 (1.8); 1.6126 (1.7); 0.0080 (7.4); -0.0002 (242.4); -0.0085 (8.1); -0.0496 (1.3) I.1-391: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.0095 (1.2); 7.9997 (1.2); 7.1738 (2.6); 7.1533 (6.7); 7.1283 (6.4); 7.1078 (2.4); 4.6657 (1.8); 4.6276 (2.0); 3.9973 (2.0); 3.9592 (1.8); 3.7202 (0.6); 3.7093 (0.8); 3.6990 (1.0); 3.6891 (0.8); 3.6782 (0.6); 3.3160 (17.9); 2.7917 (0.6); 2.6698 (0.6); 2.6054 (1.3); 2.6001 (0.9); 2.5866 (4.0); 2.5822 (2.0); 2.5676 (4.1); 2.5481 (1.5); 2.5399 (0.6); 2.5346 (0.5); 2.5298 (0.5); 2.5233 (1.5); 2.5186 (2.2); 2.5099 (33.2); 2.5053 (72.2); 2.5007 (101.1); 2.4961 (71.3); 2.4916 (32.1); 2.4648 (1.4); 2.4534 (1.2); 2.4301 (1.6); 2.4189 (1.5); 2.3326 (1.3); 2.3276 (0.8); 2.3229 (0.6); 2.3143 (1.0); 2.2916 (0.8); 2.2657 (0.8); 2.2520 (1.0); 2.2416 (1.2); 2.2279 (1.2); 2.1997 (0.6); 2.1861 (0.6); 2.0734 (1.9); 2.0561 (0.9); 2.0512 (1.9); 2.0437 (0.7); 2.0385 (1.6); 2.0323 (0.8); 2.0246 (0.9); 2.0164 (1.5); 2.0051 (0.5); 2.0004 (0.7); 1.6865 (0.6); 1.6757 (0.8); 1.6655 (0.7); 1.6540 (0.6); 1.6436 (0.7); 1.1837 (7.1); 1.1751 (0.8); 1.1647 (16.0); 1.1457 (6.8); 0.6097 (1.0); 0.5977 (2.4); 0.5928 (3.1); 0.5808 (2.8); 0.5749 (2.5); 0.5633 (1.1); 0.3582 (1.1); 0.3474 (3.0); 0.3407 (2.7); 0.3374 (2.6); 0.3314 (2.5); 0.3212 (0.8); 0.0080 (1.6); -0.0002 (54.8); - 0.0086 (1.6) I.1-392: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.9258 (1.0); 8.9045 (1.0); 7.3517 (0.8); 7.3494 (1.1); 7.3453 (1.1); 7.3432 (1.2); 7.3280 (2.7); 7.3228 (2.1); 7.3126 (2.9); 7.3066 (2.5); 7.2681 (3.8); 7.2571 (4.1); 7.2507 (2.9); 7.2477 (2.5); 7.2390 (2.9); 7.2314 (0.6); 7.2283 (0.6); 7.1779 (2.2); 7.1577 (3.8); 7.0996 (3.4); 7.0792 (2.0); 6.1162 (1.3); 6.0949 (1.2); 4.6735 (1.1); 4.6356 (1.2); 3.9725 (1.2); 3.9344 (1.1); 3.7317 (0.5); 3.7218 (0.6); 3.7117 (0.5); 3.3556 (12.2); 2.8645 (0.7); 2.8472 (0.9); 2.8299 (0.7); 2.6741 (0.5); 2.6693 (1.2); 2.6651 (0.6); 2.6576 (0.7); 2.6341 (0.8); 2.6231 (0.7); 2.5442 (0.7); 2.5395 (0.8); 2.5339 (0.8); 2.5230 (2.1); 2.5183 (3.0); 2.5096 (33.6); 2.5051 (71.0); 2.5004 (98.0); 2.4958 (68.0); 2.4913 (29.7); 2.4447 (0.5); 2.3405 (0.9); 2.3321 (1.0); 2.3273 (0.8); 2.3223 (0.7); 2.3182 (1.2); 2.3060 (0.9); 2.2908 (0.5); 2.2838 (0.7); 2.2471 (0.5); 2.2365 (0.6); 2.2230 (0.6); 1.1837 (16.0); 1.1664 (15.8); 0.0080 (1.0); -0.0002 (30.6); -0.0086 (0.8) I.1-393: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 7.1728 (8.2); 7.1553 (1.7); 7.1468 (1.2); 7.1431 (1.4); 7.1322 (1.8); 7.1182 (0.9); 7.1129 (1.0); 5.0468 (1.0); 5.0371 (1.0); 4.7629 (0.9); 4.7439 (0.6); 4.7235 (1.3); 4.7182 (1.1); 4.7102 (0.7); 4.6789 (1.2); 4.1698 (0.7); 4.1521 (0.9); 4.1359 (0.9); 4.1173 (2.0); 4.1072 (2.2); 4.1037 (1.8); 4.0991 (2.0); 4.0900 (3.8); 4.0861 (1.8); 4.0813 (1.2); 4.0724 (3.2); 4.0548 (1.4); 3.7241 (0.6); 3.7139 (0.6); 3.7040 (0.7); 3.6942 (0.7); 3.6800 (0.7); 3.6687 (0.9); 3.6606 (0.9); 3.4557 (2.5); 3.1678 (0.7); 2.8472 (0.6); 2.8377 (0.5); 2.8074 (0.7); 2.7978 (0.6); 2.7473 (0.6); 2.7386 (0.5); 2.5554 (0.6); 2.5490 (0.9); 2.5326 (0.6); 2.5233 (1.6); 2.5184 (1.9); 2.5098 (22.9); 2.5052 (48.4); 2.5006 (66.7); 2.4960 (46.0); 2.4914 (20.4); 2.4664 (0.8); 2.4606 (1.0); 2.4371 (0.7); 2.4207 (1.1); 2.3977 (0.9); 2.3272 (0.6); 2.2897 (0.5); 2.2787 (1.0); 2.2656 (0.8); 2.2543 (1.1); 2.2480 (0.9); 2.2183 (16.0); 2.2133 (6.1); 2.1989 (3.5); 2.1553 (0.5); 2.1317 (0.8); 2.1226 (0.8); 2.1118 (0.8); 2.1047 (0.8); 2.0807 (1.0); 2.0731 (1.0); 2.0424 (0.7); 1.6828 (0.6); 1.6729 (0.7); 1.6596 (0.7); 1.6499 (1.0); 1.6405 (0.9); 1.6270 (1.0); 1.6169 (1.0); 1.5949 (1.1); 1.5621 (1.0); 1.2197 (2.1); 1.2020 (4.4); 1.1892 (4.0); 1.1842 (3.0); 1.1812 (2.4); 1.1713 (10.2); 1.1633 (3.7); 1.1533 (9.9); 1.1457 (1.8); 1.1354 (3.4); 0.0080 (0.7); -0.0002 (25.0); -0.0085 (0.7) I.1-395: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.3570 (0.9); 7.3344 (0.9); 7.1983 (0.6); 7.1903 (0.9); 7.1871 (0.9); 7.1785 (1.0); 7.1704 (0.7); 7.1667 (0.8); 7.1583 (0.5); 7.0993 (0.7); 7.0831 (0.9); 7.0642 (0.7); 4.7584 (1.3); 4.7187 (1.6); 4.2737 (1.3); 4.2341 (1.1); 4.1986 (0.7); 4.1597 (0.6); 4.0877 (2.2); 3.9436 (3.9); 3.9370 (3.8); 3.8362 (0.7); 3.8255 (0.9); 3.8158 (0.8); 3.8049 (0.6); 3.3304 (61.3); 2.9487 (16.0); 2.8403 (0.7); 2.8300 (0.7); 2.7997 (0.9); 2.7895 (1.0); 2.7633 (7.2); 2.6754 (0.6); 2.6708 (0.9); 2.6663 (0.6); 2.5293 (1.7); 2.5243 (3.2); 2.5196 (4.6); 2.5109 (49.9); 2.5064 (105.5); 2.5018 (145.5); 2.4972 (101.6); 2.4927 (44.8); 2.4726 (0.8); 2.4680 (1.1); 2.4634 (1.0); 2.4562 (1.0); 2.4513 (1.1); 2.4469 (0.9); 2.4334 (0.8); 2.4137 (0.7); 2.3999 (0.7); 2.3777 (0.6); 2.3374 (0.8); 2.3333 (0.8); 2.3286 (1.1); 2.3239 (0.8); 2.2660 (0.7); 2.2543 (0.7); 2.2416 (1.2); 2.2302 (1.1); 2.2004 (0.9); 2.1942 (1.4); 2.1795 (0.8); 2.1676 (0.6); 2.1605 (0.5); 2.1487 (0.9); 2.1286 (0.5); 2.1246 (0.6); 1.6732 (0.6); 0.0080 (1.6); -0.0002 (51.1); -0.0086 (1.4) I.1-397: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 7.9285 (0.7); 7.9140 (1.4); 7.8997 (0.7); 7.1445 (2.0); 7.1243 (7.4); 7.1093 (8.2); 7.0886 (2.2); 4.6685 (2.0); 4.6306 (2.2); 4.0119 (2.2); 3.9740 (2.0); 3.7161 (0.5); 3.7052 (0.9); 3.6943 (1.2); 3.6832 (1.5); 3.6743 (1.5); 3.6631 (1.5); 3.6528 (1.3); 2.8885 (1.3); 2.8713 (2.6); 2.8562 (2.7); 2.8396 (1.3); 2.5247 (0.7); 2.5200 (1.0); 2.5112 (16.1); 2.5067 (33.0); 2.5021 (46.4); 2.4975 (32.6); 2.4929 (14.4); 2.4768 (1.8); 2.4659 (1.6); 2.3430 (1.1); 2.3242 (1.1); 2.3200 (1.0); 2.3007 (0.9); 2.2755 (16.0); 2.2561 (1.2); 2.2459 (1.3); 2.2320 (1.2); 2.2143 (0.6); 2.2041 (0.6); 2.1902 (0.6); 2.1319 (1.6); 2.1093 (1.6); 2.0976 (1.4); 2.0750 (1.4); 2.0393 (0.7); 2.0348 (0.5); 2.0267 (0.6); 2.0201 (0.5); 2.0151 (0.7); 2.0078 (0.9); 2.0028 (0.6); 1.9883 (0.6); 1.9835 (0.7); 1.7026 (0.6); 1.6917 (0.9); 1.6812 (1.0); 1.6672 (1.5); 1.6595 (1.8); 1.6359 (3.6); 1.6057 (2.3); 1.3373 (0.6); 1.3285 (0.7); 1.3200 (0.6); 1.1666 (0.8); 1.1339 (1.9); 1.1093 (1.4); 0.8712 (0.6); 0.8434 (1.3); 0.8193 (1.1); -0.0002 (9.0) I.1-398: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.3034 (1.9); 8.2982 (2.0); 8.2906 (2.1); 8.2856 (2.0); 8.2727 (1.4); 8.2644 (0.9); 7.7136 (1.2); 7.7084 (2.0); 7.7026 (1.4); 7.6929 (1.9); 7.6882 (2.8); 7.6821 (1.8); 7.6752 (0.9); 7.6692 (1.3); 7.6634 (0.7); 7.4907 (5.5); 7.4836 (1.3); 7.4702 (4.6); 7.4631 (1.0); 5.0695 (0.8); 5.0600 (0.9); 5.0437 (0.9); 5.0333 (0.9); 4.6988 (1.3); 4.6603 (2.0); 4.6456 (0.6); 4.6252 (1.8); 4.6064 (0.7); 4.5869 (1.6); 4.2755 (1.9); 4.2365 (1.3); 4.2126 (2.6); 4.1731 (2.5); 4.1639 (1.5); 4.1463 (2.3); 4.1388 (1.2); 4.1291 (3.4); 4.1208 (1.6); 4.1130 (5.7); 4.1023 (1.2); 4.0953 (5.5); 4.0933 (4.3); 4.0846 (0.7); 4.0775 (1.8); 4.0754 (1.5); 3.8875 (1.2); 3.8760 (1.6); 3.8676 (2.0); 3.8562 (2.7); 3.8430 (3.1); 3.8324 (3.7); 3.8221 (4.7); 3.8020 (6.4); 3.7913 (6.9); 3.6761 (1.2); 3.1688 (0.8); 3.0576 (0.6); 3.0502 (0.8); 3.0257 (1.2); 3.0182 (1.3); 2.9932 (0.8); 2.9859 (0.7); 2.8683 (0.9); 2.8558 (0.8); 2.8418 (0.5); 2.8273 (1.3); 2.8143 (1.3); 2.7843 (1.0); 2.7732 (0.9); 2.5838 (1.0); 2.5701 (0.6); 2.5632 (1.1); 2.5504 (1.0); 2.5437 (1.0); 2.5413 (1.1); 2.5243 (1.4); 2.5199 (1.6); 2.5112 (23.8); 2.5066 (52.1); 2.5019 (72.8); 2.4973 (51.2); 2.4927 (22.9); 2.4736 (1.2); 2.4643 (0.5); 2.4531 (1.2); 2.4473 (1.0); 2.4329 (1.3); 2.4231 (1.5); 2.4131 (1.4); 2.4061 (1.5); 2.3995 (1.3); 2.3830 (1.4); 2.3659 (0.9); 2.3517 (0.6); 2.3335 (0.8); 2.3288 (0.8); 2.3167 (0.6); 2.2959 (0.5); 2.2820 (1.0); 2.2693 (1.1); 2.2576 (1.7); 2.2447 (1.7); 2.2163 (1.2); 2.2059 (1.6); 2.1892 (0.9); 2.1790 (0.8); 2.1699 (1.1); 2.1580 (1.1); 2.1485 (1.3); 2.1391 (1.2); 2.1269 (0.6); 2.1146 (1.0); 2.0953 (1.1); 2.0738 (0.7); 2.0565 (1.0); 1.6859 (0.7); 1.6754 (0.8); 1.6678 (1.0); 1.6545 (1.4); 1.6405 (2.0); 1.6334 (1.8); 1.6225 (2.2); 1.6150 (2.2); 1.6013 (2.2); 1.5818 (1.7); 1.5682 (1.4); 1.5430 (0.9); 1.5338 (0.8); 1.5283 (0.9); 1.5191 (0.8); 1.5098 (0.9); 1.4999 (0.8); 1.4949 (0.8); 1.4857 (0.6); 1.3657 (0.5); 1.2485 (0.7); 1.2376 (1.0); 1.2115 (4.4); 1.1938 (12.6); 1.1880 (4.3); 1.1843 (7.2); 1.1760 (16.0); 1.1702 (6.2); 1.1665 (12.9); 1.1583 (6.0); 1.1525 (3.1); 1.1488 (5.7); -0.0002 (3.8) I.1-399: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.9127 (2.5); 8.8915 (2.5); 7.3674 (0.7); 7.3631 (0.7); 7.3467 (2.9); 7.3441 (4.4); 7.3407 (4.8); 7.3369 (2.2); 7.3281 (5.6); 7.3253 (7.7); 7.3223 (9.0); 7.3197 (7.9); 7.3076 (6.5); 7.3061 (6.5); 7.3040 (7.8); 7.2602 (3.9); 7.2530 (16.0); 7.2446 (5.8); 7.2358 (9.1); 7.2342 (9.0); 7.2326 (8.8); 7.2306 (7.7); 7.2179 (1.2); 7.2146 (0.5); 7.1875 (0.7); 7.1838 (0.8); 7.1749 (0.8); 7.1710 (1.0); 7.1677 (1.4); 7.1641 (1.5); 7.1547 (1.4); 7.1516 (1.6); 7.1474 (0.9); 7.1434 (0.9); 7.1345 (0.8); 7.1312 (0.8); 7.0651 (1.4); 7.0491 (2.0); 7.0298 (1.0); 6.1058 (3.1); 6.0846 (3.1); 4.7250 (2.2); 4.6854 (2.5); 4.2205 (2.7); 4.1809 (2.3); 3.8221 (0.9); 3.8116 (1.3); 3.8012 (1.5); 3.7913 (1.3); 3.7807 (0.9); 3.3166 (219.2); 3.2928 (12.2); 3.2839 (0.6); 3.2654 (0.5); 2.6706 (2.3); 2.6651 (1.1); 2.6603 (2.1); 2.6364 (2.2); 2.6253 (2.0); 2.5492 (0.5); 2.5447 (0.8); 2.5400 (1.3); 2.5351 (0.9); 2.5304 (0.9); 2.5232 (2.7); 2.5185 (4.0); 2.5098 (54.1); 2.5052 (116.7); 2.5006 (162.6); 2.4960 (113.6); 2.4914 (50.3); 2.3839 (2.4); 2.3621 (2.8); 2.3492 (2.0); 2.3387 (1.7); 2.3320 (1.2); 2.3274 (2.9); 2.3187 (1.8); 2.2966 (1.2); 2.2676 (1.1); 2.2545 (1.4); 2.2436 (1.7); 2.2306 (1.7); 2.2127 (0.6); 2.2017 (0.9); 2.1888 (0.8); 2.1244 (0.6); 2.1047 (1.0); 2.0927 (0.8); 2.0809 (1.0); 2.0730 (1.6); 2.0613 (0.5); 2.0535 (0.8); 2.0492 (1.0); 1.7908 (0.6); 1.7783 (0.8); 1.7676 (1.1); 1.7577 (1.0); 1.7461 (1.0); 1.7358 (1.0); 1.7247 (0.6); 0.0080 (0.6); -0.0002 (18.5); -0.0086 (0.5) I.1-400: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 7.8779 (0.6); 7.1436 (1.1); 7.1234 (4.0); 7.1083 (4.5); 7.1028 (0.9); 7.0876 (1.2); 4.6651 (1.1); 4.6271 (1.2); 4.0106 (1.2); 3.9727 (1.1); 3.7011 (0.5); 3.6903 (0.6); 3.6810 (0.5); 3.4361 (2.0); 3.0460 (0.5); 3.0423 (0.9); 3.0374 (0.6); 3.0329 (1.0); 3.0283 (0.9); 3.0234 (0.7); 3.0192 (0.9); 2.5103 (4.5); 2.5057 (10.0); 2.5011 (14.0); 2.4964 (9.9); 2.4918 (4.6); 2.4778 (0.8); 2.4545 (0.9); 2.4434 (0.8); 2.3402 (0.6); 2.3212 (0.6); 2.3176 (0.5); 2.2758 (8.8); 2.2676 (0.9); 2.2533 (0.7); 2.2431 (0.8); 2.2292 (0.8); 2.1060 (1.0); 2.0835 (1.0); 2.0717 (0.9); 2.0491 (0.9); 2.0092 (0.5); 1.5568 (0.6); 1.5400 (0.9); 1.5232 (0.8); 1.2811 (1.1); 1.2632 (2.8); 1.2456 (2.7); 1.2276 (0.9); 0.8548 (16.0); 0.8382 (15.4); -0.0002 (1.5) I.1-401: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.0162 (0.7); 8.0064 (0.7); 7.2049 (2.1); 7.1847 (3.9); 7.1340 (3.4); 7.1136 (1.9); 4.6736 (1.2); 4.6354 (1.3); 3.9877 (1.2); 3.9495 (1.1); 3.7164 (0.5); 3.7062 (0.6); 3.6962 (0.5); 2.8773 (0.7); 2.8601 (1.0); 2.8428 (0.7); 2.5918 (0.5); 2.5833 (0.8); 2.5734 (0.8); 2.5650 (0.5); 2.5190 (0.6); 2.5103 (6.8); 2.5058 (14.6); 2.5011 (20.2); 2.4965 (14.1); 2.4920 (6.2); 2.4769 (0.8); 2.4656 (0.8); 2.4422 (0.9); 2.4309 (0.8); 2.3346 (0.6); 2.3154 (0.6); 2.2537 (0.6); 2.2433 (0.7); 2.2297 (0.7); 2.0858 (1.0); 2.0634 (1.3); 2.0509 (1.1); 2.0290 (1.1); 1.1950 (16.0); 1.1884 (1.2); 1.1777 (15.7); 1.1715 (0.9); 0.6106 (0.6); 0.5986 (1.4); 0.5937 (1.8); 0.5818 (1.7); 0.5758 (1.6); 0.5644 (0.7); 0.3592 (0.7); 0.3483 (1.9); 0.3416 (1.6); 0.3382 (1.6); 0.3323 (1.5); -0.0002 (8.8) I.1-402: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.1670 (1.2); 8.1634 (0.6); 8.1528 (0.6); 8.1492 (1.2); 7.2025 (0.9); 7.1871 (0.5); 7.1823 (1.9); 7.1423 (1.7); 7.1219 (0.9); 6.8012 (1.2); 6.7974 (0.7); 6.7873 (0.7); 6.7833 (1.2); 4.6736 (0.6); 4.6352 (0.6); 4.0119 (0.6); 3.9737 (0.6); 3.0703 (16.0); 3.0668 (2.2); 3.0483 (1.3); 2.9434 (7.3); 2.6120 (0.9); 2.5107 (4.0); 2.5061 (8.9); 2.5015 (12.5); 2.4969 (8.9); 2.4924 (4.1); 1.1952 (7.7); 1.1779 (8.8); 1.1593 (2.9); 1.1411 (1.3); -0.0002 (4.7) I.1-409: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.1537 (0.6); 8.1400 (1.1); 8.1257 (0.6); 7.1495 (1.6); 7.1293 (5.4); 7.1138 (6.0); 7.0931 (1.6); 4.6803 (1.4); 4.6422 (1.5); 4.0201 (1.6); 3.9819 (1.4); 3.7152 (0.7); 3.7047 (0.8); 3.6947 (0.7); 3.6839 (0.5); 3.3370 (20.0); 3.1848 (0.5); 3.1414 (0.8); 3.1242 (1.7); 3.1095 (3.1); 3.0991 (2.9); 3.0925 (2.8); 3.0816 (3.1); 3.0642 (1.4); 3.0479 (0.6); 3.0200 (0.6); 3.0081 (0.9); 2.9934 (1.0); 2.9809 (0.9); 2.9696 (0.6); 2.7766 (1.1); 2.5211 (1.2); 2.5107 (11.3); 2.5062 (23.1); 2.5015 (32.3); 2.4969 (22.5); 2.4923 (10.1); 2.4868 (1.6); 2.4757 (1.2); 2.3541 (0.8); 2.3315 (0.8); 2.3118 (0.6); 2.2780 (11.7); 2.2699 (1.3); 2.2593 (1.0); 2.2453 (0.9); 2.1569 (1.2); 2.1344 (1.2); 2.1220 (1.0); 2.0994 (1.0); 2.0732 (1.2); 2.0679 (0.5); 2.0437 (0.5); 2.0364 (0.6); 2.0120 (0.5); 1.7371 (1.0); 1.7270 (1.1); 1.7167 (1.5); 1.7093 (1.3); 1.6956 (1.3); 1.6847 (0.7); 1.2137 (0.8); 1.1956 (1.8); 1.1825 (7.1); 1.1644 (16.0); 1.1462 (6.7); 1.1251 (1.2); - 0.0002 (2.0) I.1-414: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 9.0195 (1.8); 9.0157 (2.0); 9.0085 (2.0); 9.0047 (1.9); 8.6720 (1.2); 8.6498 (1.2); 8.5925 (0.7); 8.5779 (1.4); 8.5632 (0.7); 8.0121 (2.0); 7.9909 (2.5); 7.8176 (1.8); 7.7999 (2.2); 7.7966 (1.7); 7.7786 (1.7); 7.6990 (1.4); 7.6881 (1.4); 7.6777 (1.4); 7.6667 (1.2); 7.5966 (2.1); 7.5790 (1.8); 7.1255 (2.7); 7.1056 (6.7); 7.0832 (7.5); 7.0628 (2.6); 6.8939 (0.6); 4.8201 (0.6); 4.8057 (0.6); 4.7825 (1.5); 4.7683 (1.5); 4.7432 (1.5); 4.7294 (1.6); 4.7049 (0.6); 4.6923 (0.6); 4.6448 (1.9); 4.6069 (2.2); 3.9873 (2.6); 3.9490 (2.5); 3.7521 (4.9); 3.7414 (5.0); 3.7301 (4.9); 3.7209 (4.5); 3.7099 (3.8); 3.1660 (3.8); 2.7560 (0.5); 2.6747 (1.0); 2.6701 (1.4); 2.6654 (1.1); 2.6002 (1.3); 2.5893 (1.1); 2.5655 (1.7); 2.5548 (1.9); 2.5403 (0.9); 2.5235 (3.8); 2.5188 (5.4); 2.5102 (77.3); 2.5056 (168.9); 2.5010 (235.3); 2.4963 (164.7); 2.4917 (72.6); 2.3372 (0.9); 2.3324 (1.2); 2.3278 (1.6); 2.3229 (1.5); 2.3188 (1.6); 2.3004 (1.4); 2.2692 (16.0); 2.2552 (1.5); 2.2414 (1.3); 2.2311 (1.6); 2.2217 (2.0); 2.2175 (1.7); 2.1994 (2.1); 2.1872 (1.7); 2.1754 (0.7); 2.1644 (1.5); 2.1582 (0.7); 2.0732 (1.0); 2.0500 (0.8); 2.0377 (0.6); 2.0260 (0.8); 2.0186 (0.9); 1.9942 (0.7); 1.7034 (0.6); 1.6928 (0.9); 1.6825 (0.7); 1.6711 (0.7); 1.6610 (0.7); 0.0118 (0.6); 0.0110 (0.6); 0.0102 (0.7); 0.0079 (4.4); 0.0063 (1.5); 0.0055 (1.7); 0.0047 (2.0); 0.0038 (2.6); 0.0029 (4.1); 0.0022 (6.6); -0.0002 (144.5); -0.0027 (7.7); -0.0043 (2.8); -0.0052 (1.8); -0.0060 (1.3); -0.0068 (1.2); - 0.0085 (4.1); -0.0099 (0.8); -0.0108 (0.6); -0.0116 (0.5) I.1-415: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.3132 (1.5); 8.3054 (1.8); 8.2939 (12.5); 8.2890 (12.9); 8.2876 (12.2); 7.9887 (4.1); 7.9787 (4.1); 7.7399 (0.8); 7.7336 (0.8); 7.7192 (1.7); 7.7130 (1.8); 7.7071 (8.0); 7.7007 (8.0); 7.6865 (9.4); 7.6802 (9.4); 7.4954 (16.0); 7.4940 (16.0); 7.4749 (13.2); 7.4734 (13.3); 5.5653 (0.6); 5.5614 (0.6); 4.8408 (0.6); 4.8245 (0.7); 4.8085 (0.6); 4.7904 (0.6); 4.6152 (9.4); 4.5761 (11.2); 4.4426 (2.0); 4.3359 (1.7); 4.3217 (1.7); 4.3118 (2.3); 4.2973 (2.2); 4.2688 (1.7); 4.1918 (10.2); 4.1526 (8.5); 3.8136 (1.4); 3.8014 (3.1); 3.7932 (3.1); 3.7813 (5.4); 3.7699 (3.2); 3.7613 (3.1); 3.7495 (1.6); 3.1671 (0.6); 2.8937 (0.5); 2.7866 (0.7); 2.7745 (0.8); 2.6758 (1.0); 2.6711 (1.3); 2.6663 (0.9); 2.6053 (1.1); 2.5951 (2.6); 2.5853 (3.6); 2.5769 (5.8); 2.5671 (6.8); 2.5573 (4.5); 2.5492 (3.7); 2.5413 (2.2); 2.5245 (2.8); 2.5199 (4.8); 2.5112 (71.5); 2.5065 (158.5); 2.5019 (222.1); 2.4973 (156.0); 2.4927 (69.1); 2.4772 (1.8); 2.4682 (6.3); 2.4558 (6.9); 2.4328 (7.4); 2.4205 (7.0); 2.3813 (1.6); 2.3642 (2.1); 2.3576 (1.9); 2.3393 (5.0); 2.3335 (2.0); 2.3288 (2.4); 2.3217 (4.6); 2.3162 (4.2); 2.2980 (4.2); 2.2843 (4.3); 2.2694 (5.0); 2.2603 (6.1); 2.2456 (5.7); 2.2276 (1.8); 2.2184 (2.9); 2.2039 (2.7); 2.1366 (2.4); 2.1177 (3.1); 2.1129 (2.2); 2.1018 (8.4); 2.0937 (3.1); 2.0863 (4.0); 2.0810 (9.7); 2.0665 (8.0); 2.0455 (6.8); 1.7135 (1.8); 1.6991 (2.5); 1.6875 (2.7); 1.6780 (2.7); 1.6670 (2.7); 1.6638 (2.3); 1.6554 (2.3); 1.6463 (1.9); 1.6316 (1.4); 0.6109 (4.2); 0.5987 (10.8); 0.5938 (14.5); 0.5816 (13.6); 0.5759 (12.3); 0.5641 (5.3); 0.5420 (0.6); 0.3911 (0.7); 0.3812 (0.7); 0.3657 (0.9); 0.3507 (5.4); 0.3394 (12.6); 0.3336 (10.8); 0.3294 (11.0); 0.3240 (10.9); 0.3130 (3.9); 0.0081 (3.1); -0.0002 (102.8); -0.0086 (2.7) I.1-417: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 7.2528 (0.5); 7.2263 (0.6); 7.2246 (0.6); 7.2081 (1.4); 7.1964 (0.5); 7.1901 (0.6); 7.1617 (0.7); 7.1415 (1.3); 7.1024 (0.7); 7.0869 (0.7); 7.0822 (0.5); 3.6001 (6.1); 3.1336 (1.1); 3.1216 (1.2); 3.1154 (3.7); 3.1034 (3.7); 3.0971 (3.7); 3.0851 (3.7); 3.0790 (1.2); 3.0670 (1.3); 2.5820 (0.5); 2.5626 (0.6); 2.5187 (0.8); 2.5100 (11.1); 2.5055 (24.3); 2.5008 (33.8); 2.4962 (23.8); 2.4916 (10.7); 1.1944 (7.2); 1.1762 (16.0); 1.1579 (9.1); 1.1415 (1.0); 1.1389 (1.0); -0.0002 (16.2) I.1-419: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.2217 (2.2); 7.2088 (5.8); 7.1790 (0.8); 7.1718 (1.2); 7.1603 (1.5); 7.1523 (2.0); 7.1391 (1.5); 7.1303 (2.0); 7.1087 (0.8); 7.0884 (1.0); 7.0699 (0.6); 4.7986 (0.8); 4.7828 (1.4); 4.7599 (1.1); 4.7438 (1.6); 4.1180 (1.5); 4.0721 (3.3); 4.0547 (0.9); 4.0161 (1.0); 3.9762 (1.3); 3.9328 (3.6); 3.9195 (3.6); 3.8761 (0.5); 3.7184 (0.9); 3.5901 (0.9); 3.4810 (7.5); 3.1676 (1.4); 2.9247 (16.0); 2.8786 (1.2); 2.8372 (0.5); 2.7910 (0.9); 2.7817 (0.8); 2.7528 (7.9); 2.7270 (0.6); 2.6744 (1.1); 2.6697 (1.7); 2.6650 (1.4); 2.6240 (1.3); 2.6048 (3.0); 2.5853 (3.6); 2.5656 (2.0); 2.5232 (4.0); 2.5184 (6.3); 2.5098 (95.5); 2.5052 (207.9); 2.5006 (289.3); 2.4960 (203.2); 2.4914 (92.1); 2.4510 (1.7); 2.4438 (1.7); 2.4222 (1.0); 2.3797 (0.9); 2.3563 (1.0); 2.3323 (1.4); 2.3275 (1.8); 2.3227 (1.3); 2.2675 (0.9); 2.2572 (1.0); 2.2430 (1.3); 2.2329 (1.0); 2.2166 (0.7); 2.2017 (0.8); 2.1924 (0.7); 2.1171 (0.8); 2.0936 (0.8); 2.0859 (1.0); 2.0729 (0.7); 2.0629 (0.8); 1.6652 (0.9); 1.6568 (0.8); 1.6493 (0.6); 1.6340 (0.7); 1.1688 (0.6); 1.1538 (0.8); 1.1394 (4.5); 1.1281 (2.7); 1.1207 (10.2); 1.1095 (5.6); 1.1019 (4.6); 1.0905 (2.3); 0.0080 (2.3); -0.0002 (87.3); -0.0085 (2.8) I.1-420: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.4218 (1.1); 7.4038 (2.9); 7.3850 (2.4); 7.3608 (1.0); 7.3437 (0.9); 7.1807 (4.5); 7.1770 (6.3); 7.1714 (2.9); 7.1595 (4.5); 7.1508 (1.5); 7.0673 (2.3); 7.0484 (1.6); 6.8775 (2.1); 6.8541 (0.9); 4.4165 (0.8); 4.3787 (0.9); 3.9651 (0.9); 3.9264 (0.8); 3.7882 (0.9); 3.7785 (1.0); 3.7689 (0.9); 3.7582 (0.6); 3.6080 (2.0); 3.1038 (6.3); 2.5235 (1.5); 2.5188 (2.1); 2.5101 (25.4); 2.5055 (54.6); 2.5009 (75.9); 2.4963 (53.0); 2.4918 (23.7); 2.4182 (0.7); 2.3845 (0.8); 2.3277 (0.5); 2.2617 (16.0); 2.2266 (1.4); 2.2128 (1.4); 2.1208 (0.7); 2.1010 (0.8); 2.0892 (0.8); 2.0733 (1.1); 2.0321 (0.5); 2.0114 (0.6); 1.6176 (0.6); -0.0002 (15.1) I.1-421: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.1892 (1.1); 8.1860 (0.6); 8.1740 (0.6); 8.1708 (1.1); 7.2303 (0.7); 7.2116 (1.7); 7.1929 (1.0); 7.0782 (1.0); 7.0594 (0.7); 7.0246 (1.5); 7.0113 (1.0); 6.9918 (0.8); 6.8744 (1.1); 6.8710 (0.6); 6.8598 (0.6); 6.8560 (1.1); 5.3212 (1.8); 4.6616 (1.0); 4.6230 (1.1); 4.0322 (1.1); 3.9937 (1.0); 3.7446 (0.5); 3.4001 (0.6); 3.3884 (0.6); 3.3777 (0.7); 3.3692 (0.8); 3.3573 (1.1); 3.3202 (1.9); 3.2996 (1.8); 3.2634 (0.9); 3.2211 (0.7); 3.1147 (16.0); 3.1099 (5.7); 3.0895 (1.2); 3.0711 (1.2); 3.0596 (11.0); 3.0305 (0.7); 3.0155 (0.7); 3.0014 (0.6); 2.9976 (0.6); 2.9835 (0.6); 2.9304 (0.7); 2.6843 (1.7); 2.6358 (0.7); 2.6250 (0.7); 2.5986 (0.8); 2.5878 (0.8); 2.5234 (1.2); 2.5187 (1.8); 2.5100 (23.5); 2.5055 (50.2); 2.5009 (69.7); 2.4963 (49.0); 2.4917 (22.1); 2.3773 (0.6); 2.3579 (0.6); 2.3329 (0.7); 2.3276 (0.7); 2.2875 (9.1); 2.2763 (0.8); 2.2649 (0.8); 2.2539 (1.1); 2.2320 (0.9); 2.2231 (0.5); 2.2172 (0.8); 2.1948 (0.7); 2.0967 (0.5); 2.0731 (0.6); 1.1864 (0.8); 1.1682 (1.6); 1.1499 (0.8); 0.9981 (1.1); 0.9835 (0.8); 0.9801 (2.4); 0.9622 (1.1); 0.0080 (0.8); -0.0002 (27.8); -0.0086 (0.8) I.1-422: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.2095 (2.2); 7.2052 (1.7); 7.1893 (4.3); 7.1850 (2.3); 7.1443 (3.5); 7.1238 (1.9); 7.1163 (1.6); 7.0959 (0.9); 4.6986 (1.3); 4.6605 (1.4); 4.1738 (2.4); 4.0683 (1.3); 4.0305 (5.4); 3.9855 (0.7); 3.9472 (0.5); 3.7531 (0.5); 3.7407 (0.7); 3.7308 (0.7); 3.7209 (0.5); 3.6748 (7.0); 3.6167 (15.6); 2.9250 (14.2); 2.8763 (0.9); 2.8591 (1.2); 2.8419 (0.9); 2.8028 (0.7); 2.7929 (0.7); 2.7675 (5.3); 2.7526 (0.8); 2.5190 (0.6); 2.5103 (9.4); 2.5057 (20.6); 2.5011 (28.7); 2.4965 (20.3); 2.4919 (9.3); 2.4645 (0.9); 2.4474 (0.8); 2.4243 (0.8); 2.4193 (0.6); 2.3996 (0.6); 2.3409 (0.6); 2.2518 (0.5); 2.2397 (0.7); 2.2273 (0.6); 2.0839 (0.6); 1.1957 (7.8); 1.1912 (16.0); 1.1784 (8.0); 1.1739 (15.7); -0.0002 (2.1) I.1-423: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 10.6982 (0.5); 7.8200 (5.7); 7.1861 (1.8); 7.1787 (8.0); 7.1728 (3.8); 7.1640 (1.7); 7.1559 (0.9); 7.1192 (1.0); 7.1085 (0.9); 4.7434 (1.3); 4.7036 (1.4); 4.1010 (1.3); 4.0612 (1.2); 3.8091 (0.6); 3.7991 (0.6); 3.7867 (0.8); 3.7771 (0.7); 3.7667 (0.6); 3.5767 (16.0); 3.3796 (121.0); 3.1677 (1.6); 2.8463 (0.6); 2.8376 (0.6); 2.8098 (0.8); 2.7996 (0.8); 2.7669 (1.4); 2.7546 (1.4); 2.6747 (1.2); 2.6701 (1.7); 2.6655 (1.1); 2.5437 (1.7); 2.5393 (2.3); 2.5345 (2.8); 2.5297 (2.7); 2.5236 (5.2); 2.5188 (7.2); 2.5102 (92.1); 2.5056 (197.8); 2.5010 (274.6); 2.4964 (192.3); 2.4918 (86.1); 2.4752 (0.8); 2.4489 (0.9); 2.4283 (1.0); 2.4072 (0.7); 2.3507 (0.6); 2.3374 (0.9); 2.3325 (1.4); 2.3276 (2.3); 2.3233 (1.5); 2.3147 (1.0); 2.2841 (0.6); 2.2738 (0.7); 2.2408 (13.8); 2.2303 (2.4); 2.2104 (0.5); 2.1979 (0.6); 2.1901 (0.7); 2.1663 (0.5); 1.8481 (0.6); 1.8374 (0.6); 1.0646 (0.6); 1.0466 (1.4); 1.0287 (0.6); 0.0080 (1.4); -0.0002 (50.8); -0.0085 (1.5) I.1-424: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.1788 (2.0); 7.1634 (1.4); 7.1580 (6.7); 7.1404 (6.8); 7.1198 (2.0); 4.6950 (1.8); 4.6568 (2.0); 4.0328 (1.9); 3.9947 (1.7); 3.6934 (0.6); 3.6833 (0.8); 3.6737 (0.8); 3.6703 (0.8); 3.6608 (0.8); 3.6508 (0.6); 3.3385 (1.0); 2.7050 (1.4); 2.6955 (1.4); 2.6655 (1.8); 2.6560 (1.6); 2.6066 (1.1); 2.5877 (3.6); 2.5687 (3.7); 2.5497 (1.2); 2.5105 (4.9); 2.5059 (10.8); 2.5013 (15.0); 2.4967 (10.6); 2.4921 (4.8); 2.3946 (1.0); 2.3765 (0.7); 2.3711 (0.7); 2.3532 (0.7); 2.3169 (1.8); 2.2937 (1.7); 2.2827 (0.8); 2.2775 (1.6); 2.2690 (0.9); 2.2581 (1.3); 2.2543 (1.6); 2.2445 (1.1); 2.2164 (0.7); 2.2033 (0.7); 2.1504 (0.6); 2.1380 (0.5); 2.1196 (0.7); 2.0943 (0.5); 1.7120 (0.6); 1.7008 (0.8); 1.6899 (0.6); 1.6805 (0.6); 1.6690 (0.7); 1.1828 (6.9); 1.1639 (16.0); 1.1449 (6.8); -0.0002 (0.8) I.1-425: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 7.2311 (1.4); 7.2273 (1.7); 7.2199 (2.5); 7.2164 (4.0); 7.2132 (5.9); 7.2011 (0.8); 7.1818 (1.1); 7.1751 (1.0); 7.1629 (1.8); 7.1555 (1.8); 7.1489 (1.0); 7.1415 (1.2); 7.1241 (2.4); 7.1061 (1.2); 4.7703 (2.2); 4.7312 (2.4); 4.0959 (2.1); 4.0568 (1.9); 3.7185 (0.5); 3.6846 (0.8); 3.6756 (1.2); 3.6661 (1.0); 3.6614 (1.0); 3.6552 (1.3); 3.6525 (1.4); 3.6466 (0.9); 3.6418 (1.0); 3.6322 (1.0); 3.6234 (0.6); 2.6804 (1.4); 2.6712 (1.5); 2.6408 (1.9); 2.6316 (1.8); 2.6248 (0.9); 2.6206 (0.9); 2.6061 (2.4); 2.6017 (2.5); 2.5871 (2.5); 2.5831 (2.7); 2.5681 (0.9); 2.5646 (1.0); 2.5109 (4.5); 2.5063 (10.0); 2.5017 (14.2); 2.4971 (10.0); 2.4925 (4.5); 2.4835 (0.5); 2.4604 (0.7); 2.4401 (1.0); 2.4194 (1.1); 2.3974 (0.7); 2.3596 (2.1); 2.3362 (2.0); 2.3200 (1.7); 2.2965 (1.8); 2.2936 (1.0); 2.2821 (0.9); 2.2685 (1.2); 2.2575 (1.2); 2.2515 (0.6); 2.2407 (0.5); 2.2267 (0.8); 2.2161 (0.8); 2.1618 (0.8); 2.1501 (0.6); 2.1372 (0.6); 2.1298 (1.0); 2.1257 (0.5); 2.1094 (0.6); 2.1053 (0.7); 2.0853 (0.6); 1.7553 (0.6); 1.7419 (0.5); 1.7333 (0.9); 1.7231 (0.9); 1.7141 (0.5); 1.1423 (6.8); 1.1235 (16.0); 1.1046 (6.7); -0.0002 (2.1) I.1-431: 1 H-NMR (400.0 MHz, CDCl3): δ= 7.5189 (11.8); 7.3098 (3.4); 7.2977 (1.7); 7.2938 (1.5); 7.2913 (1.9); 7.2866 (2.1); 7.2850 (2.2); 7.2826 (2.5); 7.2802 (3.0); 7.2786 (2.6); 7.2770 (2.9); 7.2754 (3.2); 7.2746 (3.3); 7.2738 (3.7); 7.2730 (3.9); 7.2722 (4.3); 7.2706 (6.3); 7.2699 (6.5); 7.2691 (6.7); 7.2674 (10.4); 7.2666 (12.2); 7.2650 (19.2); 7.2600 (2279.1); 7.2095 (4.8); 7.1443 (5.4); 7.1388 (2.6); 7.1309 (5.6); 7.1224 (7.5); 7.1090 (7.3); 7.0998 (3.0); 7.0827 (2.2); 7.0733 (2.5); 7.0540 (8.4); 7.0439 (5.6); 7.0403 (8.6); 7.0296 (3.9); 7.0159 (9.1); 7.0104 (3.0); 6.9959 (16.0); 6.9941 (15.8); 6.9777 (2.3); 6.9723 (6.0); 5.3388 (1.7); 4.8461 (3.4); 4.8112 (3.9); 4.2304 (5.1); 4.1914 (4.6); 3.9189 (1.5); 3.9078 (2.2); 3.8983 (2.2); 3.8877 (2.2); 3.8767 (1.6); 3.7384 (3.2); 3.5069 (2.4); 3.5019 (2.2); 3.4890 (5.4); 3.4741 (4.7); 3.4699 (5.6); 3.4564 (2.4); 3.4528 (2.3); 2.7895 (5.4); 2.7716 (10.9); 2.7542 (5.0); 2.5815 (3.7); 2.5704 (3.7); 2.5453 (4.2); 2.5345 (4.2); 2.4752 (2.6); 2.4502 (2.2); 2.4334 (2.4); 2.4206 (2.5); 2.4057 (3.0); 2.3964 (3.9); 2.3819 (3.5); 2.3534 (1.6); 2.3390 (1.8); 2.2707 (1.3); 2.2513 (2.1); 2.2379 (1.8); 2.2273 (1.7); 2.2189 (2.1); 2.2009 (4.2); 2.1943 (1.9); 2.1236 (4.5); 2.1012 (4.7); 2.0874 (4.0); 2.0650 (3.8); 1.8074 (1.4); 1.7972 (1.8); 1.7886 (1.5); 1.7745 (1.6); 1.7631 (1.4); 1.7540 (1.3); 1.5442 (113.1); 1.4634 (2.2); 1.3860 (2.2); 0.0079 (4.9); -0.0002 (178.1); -0.0085 (5.8) I.1-433: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 10.6262 (0.8); 8.0512 (0.7); 7.2229 (1.9); 7.2219 (1.9); 7.2012 (2.2); 7.2001 (2.2); 7.1827 (0.5); 7.1701 (0.5); 7.0787 (1.4); 7.0728 (1.5); 7.0515 (0.6); 6.9969 (1.6); 6.9908 (1.6); 6.7182 (1.2); 6.7123 (1.1); 6.6964 (1.0); 6.6905 (1.0); 4.7360 (0.7); 4.6960 (0.8); 4.2301 (0.9); 4.1903 (0.8); 3.7837 (0.5); 3.7457 (16.0); 3.3965 (17.0); 3.3117 (0.9); 3.2930 (0.9); 2.7656 (0.9); 2.7469 (1.4); 2.7290 (0.8); 2.5236 (0.5); 2.5103 (11.5); 2.5057 (25.4); 2.5011 (34.9); 2.4965 (24.5); 2.4919 (10.9); 2.4831 (1.0); 2.4713 (0.8); 2.3420 (0.5); 2.3231 (0.6); 2.2446 (0.6); 2.2313 (0.6); 2.1974 (0.8); 2.1759 (0.7); 2.1626 (0.6); 2.1411 (0.6); 2.0730 (0.7); -0.0002 (1.6) I.1-434: 1H-NMR (400.0 MHz, d 6 -DMSO): δ= 11.8018 (6.5); 8.5752 (1.6); 8.3106 (16.0); 8.3089 (15.9); 8.3062 (13.2); 8.3044 (15.9); 7.7392 (3.6); 7.7329 (3.6); 7.7185 (7.5); 7.7158 (9.0); 7.7123 (8.0); 7.7095 (8.1); 7.6951 (9.5); 7.6888 (8.8); 7.5018 (14.4); 7.5003 (14.2); 7.4950 (4.5); 7.4935 (4.4); 7.4895 (7.1); 7.4879 (7.2); 7.4812 (12.4); 7.4797 (12.2); 7.4744 (3.4); 7.4730 (3.4); 7.4689 (5.4); 7.4674 (5.8); 4.8581 (0.9); 4.8394 (1.9); 4.8246 (2.4); 4.8075 (2.1); 4.7893 (0.9); 4.6424 (2.1); 4.6078 (8.1); 4.5685 (9.4); 4.3376 (0.7); 4.3109 (6.6); 4.2963 (6.9); 4.2712 (0.8); 4.2266 (2.7); 4.2161 (8.9); 4.1875 (2.2); 4.1767 (7.4); 3.9641 (3.2); 3.8599 (1.7); 3.8488 (3.1); 3.8382 (4.0); 3.8285 (4.7); 3.8186 (4.1); 3.8079 (3.3); 3.7965 (2.0); 3.7732 (1.7); 3.7622 (2.1); 3.7509 (2.4); 3.7419 (2.4); 3.7318 (2.6); 3.6391 (8.7); 3.5770 (3.7); 3.3928 (0.6); 3.2705 (0.6); 3.2206 (76.9); 3.1960 (1.4); 3.1652 (4.7); 3.0450 (0.7); 2.9093 (1.6); 2.7732 (0.8); 2.7648 (0.7); 2.7490 (4.8); 2.7379 (4.8); 2.7104 (6.2); 2.6994 (5.7); 2.6732 (3.2); 2.6702 (3.8); 2.6655 (2.6); 2.6624 (2.4); 2.6421 (0.5); 2.6039 (1.2); 2.5872 (0.8); 2.5671 (5.9); 2.5554 (7.9); 2.5491 (7.0); 2.5462 (4.1); 2.5406 (9.2); 2.5236 (7.8); 2.5191 (13.8); 2.5103 (170.6); 2.5057 (377.6); 2.5011 (530.9); 2.4965 (373.4); 2.4919 (166.5); 2.4765 (5.4); 2.4648 (4.2); 2.4587 (0.7); 2.4534 (2.8); 2.4444 (1.2); 2.4327 (2.2); 2.4279 (2.3); 2.4209 (2.4); 2.4096 (4.3); 2.4030 (2.9); 2.3928 (6.7); 2.3863 (5.0); 2.3703 (9.9); 2.3629 (4.2); 2.3541 (5.7); 2.3477 (4.1); 2.3325 (7.5); 2.3279 (5.2); 2.3233 (2.9); 2.3157 (1.6); 2.3079 (2.9); 2.3040 (3.8); 2.2986 (2.2); 2.2956 (2.8); 2.2912 (4.4); 2.2842 (2.9); 2.2804 (6.2); 2.2670 (6.2); 2.2554 (2.4); 2.2497 (1.6); 2.2433 (1.5); 2.2387 (3.0); 2.2260 (3.4); 2.2175 (1.8); 2.2100 (2.4); 2.1911 (3.2); 2.1790 (2.6); 2.1727 (2.6); 2.1672 (2.5); 2.1602 (3.6); 2.1549 (2.2); 2.1486 (1.7); 2.1414 (2.0); 2.1359 (2.2); 2.1171 (1.1); 2.0735 (0.6); 1.9304 (1.2); 1.9113 (1.2); 1.9073 (2.3); 1.8990 (1.1); 1.8882 (2.2); 1.8843 (1.2); 1.8798 (1.2); 1.8759 (1.9); 1.8652 (1.1); 1.8568 (1.8); 1.8531 (1.0); 1.8337 (0.8); 1.7547 (1.5); 1.7425 (2.7); 1.7315 (3.8); 1.7208 (3.2); 1.7116 (3.2); 1.7000 (3.1); 1.6891 (2.5); 1.6756 (1.8); 1.0471 (0.6); 0.1458 (0.8); 0.0495 (2.7); 0.0081 (8.2); -0.0002 (288.1); -0.0086 (7.9); -0.1496 (0.8) I.1-435: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.3377 (2.2); 8.3316 (2.3); 8.3079 (0.5); 7.8272 (4.6); 7.7406 (1.4); 7.7343 (1.4); 7.7198 (1.8); 7.7136 (1.8); 7.5038 (3.0); 7.4932 (0.7); 7.4833 (2.6); 7.4727 (0.6); 4.6706 (1.3); 4.6320 (1.6); 4.2586 (1.9); 4.2194 (1.7); 3.9041 (0.8); 3.8939 (1.1); 3.8826 (1.1); 3.8738 (1.1); 3.8631 (1.0); 3.7461 (1.6); 3.6323 (1.2); 3.6007 (16.0); 3.1649 (1.0); 2.8970 (0.6); 2.8607 (0.6); 2.6700 (1.1); 2.6653 (0.8); 2.5403 (0.9); 2.5234 (2.6); 2.5188 (3.8); 2.5101 (64.9); 2.5055 (143.2); 2.5009 (200.3); 2.4963 (140.5); 2.4917 (62.7); 2.4631 (1.2); 2.4380 (1.0); 2.4133 (1.1); 2.3952 (1.1); 2.3712 (0.9); 2.3279 (1.7); 2.3146 (0.8); 2.3044 (1.0); 2.2900 (1.0); 2.2629 (0.6); 2.2497 (0.6); 2.2360 (0.5); 2.2177 (0.7); 2.1877 (0.7); 2.1693 (0.6); 1.8254 (0.6); 1.8135 (0.6); 1.7948 (0.6); 0.0079 (3.0); -0.0002 (102.0); -0.0085 (2.9) I.1-436: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.3178 (1.1); 8.3117 (1.7); 8.2956 (2.4); 8.1843 (0.5); 8.1623 (0.5); 8.1018 (0.6); 8.0803 (0.6); 8.0579 (0.6); 8.0369 (0.6); 7.7244 (0.8); 7.7179 (1.3); 7.7096 (1.0); 7.7034 (1.9); 7.6975 (1.9); 7.6892 (1.2); 7.6828 (1.2); 7.6784 (0.8); 7.4968 (3.1); 7.4764 (2.8); 4.6618 (1.0); 4.6472 (0.7); 4.6391 (0.5); 4.6230 (1.2); 4.6086 (0.8); 4.5998 (0.6); 4.3897 (0.6); 4.3784 (0.6); 4.3678 (0.6); 4.3562 (0.7); 4.3507 (0.6); 4.3391 (0.6); 4.3290 (0.6); 4.3173 (0.8); 4.2333 (0.8); 4.2128 (2.1); 4.1933 (1.2); 4.1869 (0.8); 4.1733 (2.0); 4.1651 (0.6); 3.7733 (0.9); 3.7618 (0.9); 3.3777 (8.6); 2.6705 (1.0); 2.6607 (0.6); 2.6369 (0.6); 2.6257 (0.5); 2.6034 (0.9); 2.5821 (0.6); 2.5686 (1.0); 2.5405 (0.6); 2.5238 (1.5); 2.5191 (2.3); 2.5104 (39.0); 2.5059 (86.2); 2.5012 (120.5); 2.4966 (83.7); 2.4920 (37.2); 2.3555 (0.9); 2.3496 (1.1); 2.3328 (1.6); 2.3280 (1.9); 2.3082 (1.2); 2.2936 (1.3); 2.2732 (1.9); 2.2650 (1.1); 2.2515 (1.5); 2.2377 (0.8); 2.2234 (0.5); 2.2091 (0.5); 2.0914 (0.6); 2.0784 (0.7); 2.0675 (0.8); 2.0603 (0.8); 1.8609 (0.6); 1.8430 (0.6); 1.7444 (0.9); 1.2573 (0.5); 1.2423 (0.6); 1.1631 (0.5); 1.1451 (0.6); 1.1330 (0.6); 1.1149 (0.5); 0.8502 (10.5); 0.8333 (16.0); 0.8154 (4.4); 0.0079 (1.7); -0.0002 (55.5); -0.0085 (1.6) I.1-437: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.5763 (0.7); 8.3150 (12.6); 8.3137 (14.0); 8.3089 (13.7); 8.3074 (13.7); 8.2979 (1.1); 8.2914 (0.9); 7.7399 (1.6); 7.7337 (1.6); 7.7193 (10.2); 7.7130 (9.9); 7.6986 (10.3); 7.6923 (9.9); 7.4951 (16.0); 7.4936 (16.0); 7.4897 (3.9); 7.4880 (3.5); 7.4746 (13.6); 7.4731 (13.6); 7.4691 (3.0); 7.4675 (2.8); 7.4605 (0.6); 5.5893 (0.5); 4.8408 (0.9); 4.8255 (1.1); 4.8084 (1.0); 4.6435 (9.1); 4.6042 (11.0); 4.3379 (0.8); 4.3223 (1.0); 4.3118 (3.5); 4.2972 (3.6); 4.2723 (1.7); 4.2577 (1.5); 4.2275 (11.1); 4.1883 (9.8); 4.0855 (2.2); 3.8233 (0.6); 3.7849 (1.9); 3.7740 (3.1); 3.7631 (4.4); 3.7537 (4.5); 3.7434 (4.2); 3.7327 (3.2); 3.7216 (1.6); 3.1675 (1.0); 2.9874 (0.5); 2.9260 (0.6); 2.7131 (7.1); 2.7027 (7.3); 2.6730 (9.3); 2.6626 (8.8); 2.5682 (2.4); 2.5652 (1.2); 2.5564 (2.5); 2.5501 (2.6); 2.5415 (3.7); 2.5330 (0.7); 2.5246 (2.6); 2.5202 (5.2); 2.5112 (61.4); 2.5067 (136.8); 2.5020 (193.1); 2.4974 (137.1); 2.4928 (61.3); 2.4774 (2.3); 2.4655 (1.8); 2.4586 (0.7); 2.4541 (1.8); 2.4451 (0.8); 2.4368 (2.0); 2.4205 (2.5); 2.4107 (2.8); 2.3957 (5.3); 2.3784 (4.3); 2.3701 (12.5); 2.3566 (3.5); 2.3482 (9.3); 2.3300 (8.7); 2.3164 (1.1); 2.3082 (8.1); 2.2956 (3.9); 2.2814 (4.2); 2.2710 (6.1); 2.2571 (6.1); 2.2441 (0.9); 2.2411 (0.9); 2.2295 (3.9); 2.2181 (6.2); 2.2038 (2.7); 2.2009 (3.2); 2.1897 (3.1); 2.1846 (2.6); 2.1797 (1.6); 2.1764 (2.0); 2.1726 (3.5); 2.1654 (2.2); 2.1603 (1.6); 2.1530 (2.5); 2.1461 (2.2); 2.1286 (1.4); 1.9082 (1.0); 1.8891 (1.0); 1.8851 (0.6); 1.8807 (0.5); 1.8768 (0.8); 1.8577 (0.8); 1.7426 (1.7); 1.7327 (3.3); 1.7212 (3.7); 1.7145 (2.3); 1.7103 (2.9); 1.7036 (3.6); 1.6966 (2.2); 1.6903 (3.6); 1.6786 (2.4); 1.6650 (1.6); 0.0080 (4.2); 0.0064 (1.1); 0.0055 (1.2); 0.0047 (1.4); 0.0039 (1.9); 0.0022 (5.7); -0.0002 (148.7); -0.0026 (9.6); -0.0051 (2.7); - 0.0059 (2.0); -0.0068 (1.7); -0.0085 (4.6); -0.0107 (1.0); -0.0115 (0.9); -0.0123 (0.7); -0.0131 (0.7); - 0.0139 (0.6); -0.0147 (0.6); -0.0155 (0.5) I.1-438: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.9047 (2.5); 8.8833 (2.5); 8.2435 (4.2); 8.2384 (4.2); 7.6532 (2.7); 7.6469 (2.6); 7.6326 (3.2); 7.6263 (3.2); 7.4570 (5.4); 7.4556 (5.5); 7.4365 (4.6); 7.4351 (4.6); 7.3496 (3.0); 7.3453 (2.4); 7.3430 (3.0); 7.3393 (1.9); 7.3288 (7.4); 7.3242 (5.6); 7.3218 (6.3); 7.3129 (7.2); 7.3062 (7.0); 7.2897 (0.5); 7.2632 (12.6); 7.2551 (11.2); 7.2450 (8.9); 7.2377 (7.7); 7.2326 (4.1); 7.2269 (1.9); 7.2233 (1.5); 7.2197 (1.4); 6.1111 (3.0); 6.0899 (3.0); 4.6195 (2.8); 4.5802 (3.3); 4.1498 (3.2); 4.1108 (2.8); 3.9640 (0.7); 3.8213 (0.9); 3.8125 (1.0); 3.8013 (1.7); 3.7895 (1.1); 3.7813 (1.0); 3.5550 (2.6); 3.1653 (16.0); 2.6830 (1.8); 2.6705 (2.3); 2.6479 (2.1); 2.6358 (2.0); 2.5506 (0.6); 2.5402 (0.5); 2.5234 (1.6); 2.5187 (2.4); 2.5100 (40.0); 2.5054 (88.3); 2.5008 (123.5); 2.4962 (86.5); 2.4916 (38.4); 2.3418 (2.2); 2.3279 (2.3); 2.3209 (2.4); 2.3065 (2.9); 2.2857 (2.8); 2.2770 (1.3); 2.2622 (1.5); 2.2532 (1.7); 2.2383 (1.7); 2.2201 (0.5); 2.2115 (0.7); 2.1967 (0.7); 2.1151 (0.6); 2.0963 (0.9); 2.0833 (0.8); 2.0723 (1.0); 2.0651 (1.1); 2.0539 (0.5); 2.0408 (0.8); 1.7296 (0.8); 1.7189 (0.8); 1.7091 (0.9); 1.6977 (0.9); 1.6863 (0.8); 1.6774 (0.6); 0.0080 (1.7); -0.0002 (60.1); -0.0086 (1.6) I.1-439: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.4189 (0.6); 7.4005 (1.5); 7.3817 (1.3); 7.3540 (0.5); 7.1708 (3.6); 7.1510 (3.3); 7.0121 (1.1); 6.9940 (0.9); 3.7781 (0.5); 3.5027 (0.9); 3.1068 (3.4); 2.8819 (0.8); 2.8645 (1.1); 2.8472 (0.9); 2.5188 (0.7); 2.5101 (11.3); 2.5056 (24.8); 2.5010 (34.7); 2.4964 (24.4); 2.4918 (11.0); 2.2013 (0.8); 2.0733 (0.9); 1.2036 (16.0); 1.1863 (15.8); -0.0002 (12.7) I.1-440: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.2104 (2.4); 7.1902 (4.3); 7.1437 (2.8); 7.1274 (1.7); 7.1236 (1.8); 7.1067 (0.9); 5.0578 (0.6); 5.0489 (0.5); 4.7482 (0.6); 4.7106 (0.8); 4.6526 (0.6); 4.1683 (0.6); 4.1507 (0.9); 4.1332 (0.7); 4.1256 (0.5); 4.1131 (0.8); 4.1081 (1.0); 4.1059 (1.0); 4.0954 (2.5); 4.0905 (1.0); 4.0881 (0.8); 4.0776 (2.2); 4.0598 (1.1); 4.0554 (0.8); 4.0164 (1.0); 3.7391 (0.5); 3.7287 (0.6); 3.7183 (0.6); 3.7047 (0.5); 3.6945 (0.6); 3.6017 (2.4); 2.8766 (0.8); 2.8594 (1.2); 2.8426 (0.8); 2.5293 (0.5); 2.5234 (1.3); 2.5187 (1.7); 2.5100 (24.2); 2.5054 (52.9); 2.5008 (74.0); 2.4962 (52.5); 2.4917 (23.7); 2.4325 (0.7); 2.4126 (0.7); 2.3902 (0.9); 2.3728 (0.6); 2.2704 (0.6); 2.2585 (0.5); 2.2465 (0.7); 2.2341 (0.7); 2.2055 (0.5); 2.1090 (0.7); 2.0961 (0.6); 2.0850 (0.8); 2.0771 (0.9); 2.0732 (0.8); 2.0522 (0.6); 1.6416 (0.6); 1.6301 (0.7); 1.6113 (0.7); 1.5995 (0.7); 1.5880 (0.8); 1.5477 (0.6); 1.5297 (0.5); 1.2171 (1.8); 1.1993 (3.9); 1.1950 (6.2); 1.1894 (13.7); 1.1814 (3.0); 1.1778 (6.5); 1.1718 (16.0); 1.1610 (1.7); 1.1531 (6.2); 1.1432 (0.8); 1.1352 (2.4); - 0.0002 (5.3) I.1-441: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 7.8259 (4.8); 7.2164 (1.6); 7.1961 (4.0); 7.1678 (3.2); 7.1470 (1.4); 4.7298 (1.0); 4.6916 (1.1); 4.0565 (1.0); 4.0182 (0.9); 3.8080 (0.6); 3.5911 (12.5); 3.5066 (11.8); 3.1677 (1.5); 2.8808 (1.0); 2.8632 (1.0); 2.8460 (1.1); 2.6743 (1.0); 2.6700 (1.2); 2.6651 (0.8); 2.5232 (3.2); 2.5186 (4.8); 2.5099 (78.0); 2.5053 (170.2); 2.5007 (237.2); 2.4961 (167.3); 2.4916 (75.2); 2.4488 (0.9); 2.4311 (0.6); 2.4120 (0.7); 2.3900 (0.7); 2.3712 (0.5); 2.3320 (1.0); 2.3275 (1.4); 2.3231 (1.1); 2.3043 (0.6); 2.2938 (0.6); 2.2798 (0.7); 2.1411 (0.6); 2.0731 (0.7); 1.1946 (16.0); 1.1774 (15.7); -0.0002 (12.5) I.1-442: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 7.2275 (1.2); 7.2237 (1.5); 7.2181 (1.5); 7.2122 (3.8); 7.2102 (4.1); 7.1805 (0.6); 7.1734 (0.8); 7.1616 (1.0); 7.1537 (1.2); 7.1486 (0.9); 7.1403 (0.9); 7.1267 (1.4); 7.1087 (0.6); 7.0874 (0.6); 4.7820 (1.4); 4.7431 (1.6); 4.1869 (2.4); 4.1179 (1.1); 4.0789 (1.0); 4.0380 (0.6); 4.0254 (3.2); 4.0180 (3.1); 3.7118 (0.6); 3.6994 (0.5); 3.6917 (0.5); 3.6708 (7.8); 3.6113 (16.0); 3.4035 (20.6); 2.9426 (14.5); 2.8002 (0.6); 2.7913 (0.6); 2.7550 (5.7); 2.6698 (0.6); 2.6222 (0.7); 2.6034 (2.4); 2.5848 (2.9); 2.5660 (1.6); 2.5465 (1.0); 2.5401 (0.9); 2.5342 (1.3); 2.5233 (1.9); 2.5186 (2.7); 2.5100 (36.7); 2.5054 (77.7); 2.5008 (108.3); 2.4961 (76.0); 2.4915 (33.8); 2.4700 (0.9); 2.4443 (0.8); 2.4389 (0.5); 2.4223 (0.6); 2.3323 (0.5); 2.3276 (0.7); 2.3230 (0.7); 2.2598 (0.5); 2.2450 (0.7); 2.2351 (0.6); 2.0865 (0.6); 1.6615 (0.5); 1.6523 (0.6); 1.1399 (3.6); 1.1296 (1.9); 1.1211 (8.4); 1.1109 (4.0); 1.1022 (3.5); 1.0920 (1.6); -0.0002 (8.8) I.1-443: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.1789 (1.8); 7.1716 (6.4); 7.1660 (4.5); 7.1559 (1.5); 7.1492 (1.0); 7.1425 (0.7); 7.1169 (1.0); 7.1053 (0.8); 7.0826 (0.5); 4.7268 (1.6); 4.6874 (1.8); 4.1824 (2.5); 4.0990 (1.2); 4.0596 (1.1); 4.0236 (4.0); 4.0179 (3.6); 3.9828 (0.5); 3.7116 (0.7); 3.7011 (0.6); 3.6913 (0.6); 3.6722 (7.6); 3.6117 (16.0); 3.1680 (0.6); 2.9380 (14.8); 2.7978 (0.6); 2.7884 (0.6); 2.7551 (6.0); 2.7484 (1.0); 2.5369 (1.0); 2.5334 (0.5); 2.5233 (1.1); 2.5186 (1.4); 2.5100 (14.3); 2.5054 (29.9); 2.5008 (41.2); 2.4962 (29.0); 2.4916 (12.4); 2.4726 (0.6); 2.4583 (0.6); 2.4381 (0.7); 2.3878 (0.6); 2.2704 (0.6); 2.2564 (0.8); 2.2509 (0.6); 2.2460 (0.8); 2.2396 (0.7); 2.2231 (11.0); 2.2147 (1.0); 2.2078 (5.3); 2.1474 (0.6); 2.1156 (0.6); 1.6612 (0.5); 1.6518 (0.6); 0.0080 (0.5); -0.0002 (15.7) I.1-444: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.2065 (1.5); 7.1979 (1.4); 7.1863 (3.2); 7.1777 (2.1); 7.1451 (2.6); 7.1245 (1.4); 7.1167 (1.9); 7.0963 (1.2); 4.7035 (0.8); 4.6980 (0.9); 4.6658 (0.8); 4.6600 (1.0); 4.0717 (0.9); 4.0336 (0.9); 3.9479 (0.7); 3.9099 (0.7); 3.8923 (4.2); 3.8663 (1.4); 3.8630 (1.4); 3.7538 (0.5); 3.7437 (0.7); 3.7338 (0.7); 3.7239 (0.6); 2.9765 (0.7); 2.9673 (3.4); 2.9515 (0.7); 2.8942 (9.3); 2.8739 (1.1); 2.8565 (1.6); 2.8511 (1.6); 2.8392 (1.7); 2.8300 (3.2); 2.8124 (3.8); 2.7940 (1.3); 2.7818 (0.7); 2.7720 (1.0); 2.7483 (5.9); 2.7415 (1.0); 2.7386 (1.0); 2.7317 (0.7); 2.7101 (0.6); 2.6701 (0.6); 2.5189 (0.8); 2.5102 (13.6); 2.5056 (30.0); 2.5010 (42.0); 2.4965 (29.9); 2.4919 (13.6); 2.4545 (0.8); 2.4314 (0.8); 2.4143 (1.0); 2.3912 (0.9); 2.3122 (0.7); 2.2888 (0.5); 2.2476 (0.8); 2.2353 (0.7); 2.2230 (0.9); 2.1816 (0.5); 2.0812 (0.6); 1.1934 (10.3); 1.1907 (13.4); 1.1761 (10.3); 1.1734 (13.1); 1.0943 (7.8); 1.0762 (16.0); 1.0581 (7.6); -0.0002 (3.1) I.1-445: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 7.4171 (2.4); 7.3988 (5.9); 7.3801 (5.0); 7.3564 (2.1); 7.2401 (1.5); 7.2213 (4.5); 7.2010 (5.8); 7.1896 (5.8); 7.1639 (11.1); 7.1602 (16.0); 7.1549 (3.4); 7.1429 (10.7); 7.1399 (10.4); 7.1143 (3.0); 7.0964 (1.5); 6.9331 (2.0); 4.5561 (1.6); 4.5174 (1.8); 3.9547 (1.8); 3.9197 (1.5); 3.7483 (2.0); 3.3705 (0.6); 3.3514 (1.0); 3.3187 (341.0); 3.2683 (1.4); 3.1666 (2.2); 3.0888 (11.4); 2.6747 (1.3); 2.6700 (1.9); 2.6654 (1.4); 2.6608 (0.7); 2.5516 (1.3); 2.5235 (6.4); 2.5187 (8.8); 2.5100 (111.3); 2.5055 (243.2); 2.5008 (342.2); 2.4962 (239.3); 2.4916 (106.5); 2.4501 (1.4); 2.3836 (1.3); 2.3324 (2.6); 2.3277 (2.6); 2.3232 (2.0); 2.2184 (3.2); 2.1778 (1.0); 2.1225 (1.7); 2.0910 (2.6); 2.0730 (3.3); 1.6739 (1.4); 1.2341 (0.6); 1.0961 (6.9); 1.0775 (13.3); 1.0586 (6.4); 0.0080 (0.7); -0.0002 (24.2); -0.0086 (0.7) I.1-446: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.8292 (6.0); 7.1878 (0.8); 7.1662 (8.0); 7.1616 (7.5); 7.1398 (0.9); 7.1343 (0.7); 4.7234 (1.3); 4.6851 (1.4); 4.1054 (0.6); 4.0669 (1.9); 4.0486 (0.8); 4.0287 (1.9); 4.0109 (0.8); 3.8244 (0.6); 3.8138 (0.8); 3.8023 (0.8); 3.7924 (0.8); 3.7819 (0.6); 3.5916 (16.0); 3.1119 (0.6); 2.8740 (0.5); 2.8640 (0.6); 2.8369 (0.7); 2.8271 (0.6); 2.7697 (1.1); 2.7573 (1.1); 2.6083 (1.1); 2.5893 (3.5); 2.5703 (3.6); 2.5516 (1.3); 2.5236 (0.6); 2.5189 (1.0); 2.5103 (15.8); 2.5057 (34.8); 2.5011 (49.1); 2.4965 (35.0); 2.4919 (16.0); 2.4760 (1.0); 2.4679 (0.8); 2.4628 (0.9); 2.4377 (0.7); 2.4321 (0.5); 2.4132 (0.8); 2.3945 (0.7); 2.3902 (0.7); 2.3713 (0.6); 2.3171 (0.5); 2.3036 (0.6); 2.2926 (0.8); 2.2793 (0.8); 2.1665 (0.5); 2.1350 (0.6); 1.8130 (0.5); 1.8023 (0.5); 1.7921 (0.5); 1.1833 (5.8); 1.1644 (13.0); 1.1454 (5.7); 1.0511 (0.9); -0.0002 (4.4) I.1-447: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.2344 (1.4); 7.2155 (3.5); 7.1969 (2.3); 7.0832 (2.0); 7.0644 (1.6); 7.0317 (2.1); 7.0145 (1.9); 6.9963 (1.9); 5.0649 (1.0); 5.0571 (1.0); 5.0501 (1.0); 4.7558 (1.0); 4.7175 (1.4); 4.7097 (1.4); 4.6712 (1.7); 4.1706 (0.7); 4.1526 (1.1); 4.1347 (0.9); 4.1252 (1.0); 4.1175 (0.9); 4.1107 (2.0); 4.1075 (2.8); 4.0997 (0.9); 4.0950 (3.2); 4.0898 (2.8); 4.0824 (1.3); 4.0774 (3.1); 4.0722 (0.9); 4.0596 (1.0); 4.0473 (1.2); 4.0075 (1.0); 3.9682 (0.8); 3.7471 (0.7); 3.7419 (0.7); 3.7330 (0.7); 3.7281 (0.7); 3.7188 (0.8); 3.7093 (0.8); 3.6996 (0.6); 3.6719 (0.7); 3.4407 (6.2); 2.8714 (0.7); 2.8617 (0.7); 2.8315 (0.9); 2.8216 (0.9); 2.7779 (0.6); 2.7683 (0.6); 2.6698 (0.6); 2.5287 (1.0); 2.5233 (1.9); 2.5185 (2.6); 2.5099 (32.9); 2.5053 (71.3); 2.5007 (99.0); 2.4961 (69.4); 2.4915 (31.1); 2.4801 (1.0); 2.4644 (1.1); 2.4611 (1.2); 2.4561 (1.3); 2.4514 (1.1); 2.4464 (0.8); 2.4412 (0.9); 2.4208 (1.4); 2.3974 (1.6); 2.3811 (1.2); 2.3582 (0.8); 2.3274 (0.8); 2.3228 (0.6); 2.2856 (16.0); 2.2705 (1.2); 2.2586 (1.3); 2.2460 (1.3); 2.2409 (0.9); 2.2289 (0.6); 2.2166 (0.9); 2.2044 (0.7); 2.1337 (1.0); 2.1207 (0.6); 2.1144 (1.0); 2.1093 (0.9); 2.1013 (1.2); 2.0904 (1.3); 2.0822 (1.3); 2.0731 (1.0); 2.0576 (1.0); 1.6466 (0.9); 1.6382 (1.2); 1.6252 (1.4); 1.6146 (1.4); 1.6074 (1.2); 1.5938 (1.4); 1.5688 (1.1); 1.5448 (0.8); 1.5361 (0.8); 1.5206 (0.5); 1.5019 (0.6); 1.4868 (0.6); 1.2178 (2.3); 1.2000 (4.2); 1.1916 (4.6); 1.1822 (2.8); 1.1794 (2.6); 1.1738 (8.7); 1.1709 (4.4); 1.1616 (3.9); 1.1561 (4.5); 1.1531 (7.7); 1.1439 (1.9); 1.1353 (3.2); 0.0080 (0.6); -0.0002 (22.4); -0.0085 (0.6) I.1-515: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.2755 (0.7); 8.2547 (1.7); 8.2341 (1.2); 7.1741 (2.3); 7.1533 (8.3); 7.1384 (5.8); 7.1340 (4.1); 7.1179 (1.8); 4.6778 (2.0); 4.6398 (2.2); 4.2019 (0.7); 4.1875 (0.8); 4.1641 (0.6); 4.1440 (0.5); 4.0525 (0.8); 4.0175 (1.7); 3.9805 (1.2); 3.7054 (0.7); 3.6946 (0.9); 3.6856 (0.8); 3.3875 (14.2); 3.1680 (1.2); 2.6743 (1.1); 2.6698 (1.5); 2.6651 (1.1); 2.6057 (1.6); 2.5868 (5.1); 2.5682 (4.6); 2.5493 (2.4); 2.5399 (2.2); 2.5296 (1.9); 2.5232 (4.2); 2.5185 (6.0); 2.5099 (90.2); 2.5053 (196.6); 2.5006 (273.5); 2.4960 (191.2); 2.4914 (85.2); 2.3547 (0.8); 2.3322 (1.9); 2.3275 (2.0); 2.2726 (0.6); 2.2597 (0.8); 2.2482 (0.9); 2.2289 (1.0); 2.2182 (0.6); 2.2064 (1.1); 2.1940 (1.0); 2.1864 (1.0); 2.1713 (0.6); 2.1627 (1.0); 2.1516 (0.8); 2.1285 (0.8); 2.0064 (0.7); 1.9974 (0.7); 1.7569 (0.5); 1.7352 (0.6); 1.7248 (0.5); 1.6004 (0.7); 1.5127 (1.3); 1.5007 (2.0); 1.4875 (1.9); 1.4763 (1.4); 1.4652 (1.0); 1.1836 (7.2); 1.1645 (16.0); 1.1457 (6.8); 0.8936 (7.4); 0.8772 (7.2); 0.8287 (6.7); 0.8125 (6.6); 0.0335 (0.6); 0.0080 (4.4); 0.0064 (1.5); 0.0056 (1.8); 0.0048 (2.0); 0.0039 (2.6); -0.0002 (142.0); -0.0059 (1.7); -0.0067 (1.4); -0.0085 (4.0) I.1-516: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 12.5667 (0.9); 8.1997 (0.8); 8.1777 (0.8); 8.1480 (1.7); 8.1270 (1.8); 7.2257 (1.9); 7.2206 (2.9); 7.2115 (5.4); 7.2070 (7.8); 7.1952 (1.2); 7.1722 (1.0); 7.1669 (0.9); 7.1534 (2.4); 7.1464 (2.5); 7.1408 (2.3); 7.1364 (4.1); 7.1335 (3.6); 7.1189 (1.8); 7.1008 (0.6); 4.7684 (2.7); 4.7292 (3.0); 4.2250 (0.8); 4.2102 (0.8); 4.2035 (0.8); 4.1888 (0.8); 4.1555 (1.6); 4.1406 (1.7); 4.1347 (1.7); 4.1198 (1.6); 4.0849 (1.0); 4.0611 (2.1); 4.0458 (0.9); 4.0222 (1.9); 3.6785 (0.8); 3.6686 (0.9); 3.6583 (0.9); 3.6481 (1.1); 3.6269 (0.6); 3.3176 (97.6); 2.6744 (0.9); 2.6697 (1.3); 2.6652 (1.0); 2.6253 (1.5); 2.6091 (4.8); 2.6059 (4.6); 2.5900 (4.4); 2.5873 (4.6); 2.5771 (1.8); 2.5681 (2.7); 2.5502 (0.8); 2.5402 (1.2); 2.5233 (4.1); 2.5185 (6.3); 2.5099 (74.0); 2.5053 (158.8); 2.5007 (219.4); 2.4961 (153.2); 2.4915 (68.3); 2.4450 (0.8); 2.4227 (1.0); 2.4004 (1.0); 2.3807 (1.6); 2.3759 (1.7); 2.3540 (1.2); 2.3416 (0.7); 2.3366 (0.7); 2.3321 (1.1); 2.3275 (1.4); 2.3228 (1.2); 2.3191 (1.0); 2.3127 (1.6); 2.2890 (1.7); 2.2784 (1.9); 2.2615 (1.3); 2.2550 (1.9); 2.2452 (0.9); 2.2337 (0.7); 2.2194 (0.7); 2.2099 (0.7); 2.0607 (0.6); 2.0397 (0.9); 2.0063 (1.0); 1.9840 (0.8); 1.8404 (0.5); 1.8308 (0.8); 1.8082 (1.1); 1.7983 (1.2); 1.7901 (0.8); 1.7758 (1.2); 1.7674 (1.3); 1.7571 (1.0); 1.7459 (1.1); 1.7297 (0.8); 1.4077 (0.7); 1.4002 (0.6); 1.3891 (0.9); 1.3849 (0.8); 1.3739 (1.0); 1.3663 (0.8); 1.3553 (0.8); 1.2098 (0.8); 1.1914 (1.1); 1.1690 (1.0); 1.1533 (1.0); 1.1431 (7.2); 1.1401 (5.0); 1.1244 (16.0); 1.1213 (10.0); 1.1055 (6.9); 1.1025 (4.3); 0.8565 (5.3); 0.8468 (12.6); 0.8382 (11.8); 0.8298 (15.0); 0.8196 (4.5); 0.8122 (2.5); 0.0081 (2.4); -0.0002 (82.4); -0.0085 (2.4) I.1-517: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.9552 (2.6); 8.5539 (0.9); 8.5332 (0.9); 7.3878 (2.5); 7.1400 (1.9); 7.1201 (4.5); 7.0942 (4.8); 7.0738 (1.9); 4.6568 (0.6); 4.6370 (1.8); 4.6234 (0.6); 4.5996 (1.4); 3.9779 (1.2); 3.9399 (1.3); 3.6394 (16.0); 3.6289 (3.0); 3.3504 (22.2); 3.1613 (0.6); 3.1491 (0.7); 3.1240 (0.9); 3.1111 (0.9); 2.9957 (0.9); 2.9716 (0.8); 2.9584 (0.7); 2.9338 (0.6); 2.6737 (0.6); 2.6691 (0.9); 2.6645 (0.6); 2.5393 (0.5); 2.5335 (0.9); 2.5226 (2.9); 2.5178 (3.3); 2.5092 (49.5); 2.5046 (107.9); 2.5000 (151.2); 2.4954 (104.4); 2.4908 (47.0); 2.3314 (0.8); 2.3268 (1.1); 2.3222 (0.9); 2.3010 (0.8); 2.2736 (11.2); 2.2596 (0.7); 2.2438 (0.6); 2.2297 (0.7); 2.2198 (0.8); 2.2056 (0.8); 2.1635 (1.2); 2.1415 (0.8); 2.1280 (0.7); 2.1065 (0.7); 0.0080 (1.2); - 0.0002 (41.8); -0.0085 (1.2) I.1-518: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.3453 (1.8); 8.3245 (1.9); 7.7051 (0.6); 7.2609 (1.0); 7.2576 (1.2); 7.2436 (2.1); 7.2403 (3.0); 7.2363 (3.1); 7.2217 (8.2); 7.2154 (8.0); 7.2029 (3.3); 7.1993 (3.7); 7.1819 (2.2); 7.1730 (0.6); 7.1658 (0.7); 7.1265 (3.6); 7.1069 (6.4); 7.0805 (1.0); 7.0565 (6.5); 7.0364 (3.6); 4.5962 (2.0); 4.5584 (2.1); 4.4474 (0.7); 4.4355 (0.8); 4.4216 (1.1); 4.4148 (1.0); 4.4013 (0.9); 4.3894 (0.7); 3.8739 (2.1); 3.8360 (2.0); 3.5738 (0.7); 3.5632 (1.0); 3.5532 (1.4); 3.5431 (1.0); 3.5314 (0.8); 3.4204 (4.2); 3.1645 (0.7); 3.0876 (1.1); 3.0761 (1.2); 3.0529 (1.5); 3.0418 (1.3); 2.8341 (1.4); 2.8086 (1.5); 2.7994 (1.3); 2.7742 (1.2); 2.6697 (1.0); 2.6650 (0.7); 2.5401 (0.6); 2.5231 (0.9); 2.5185 (2.3); 2.5098 (53.5); 2.5052 (119.7); 2.5006 (168.6); 2.4960 (118.5); 2.4914 (53.6); 2.4791 (3.0); 2.4724 (2.3); 2.4681 (2.8); 2.4451 (1.8); 2.4346 (1.5); 2.3321 (0.7); 2.3275 (1.0); 2.3226 (0.7); 2.2708 (16.0); 2.2529 (1.4); 2.2324 (1.4); 2.2097 (0.9); 2.1844 (0.9); 2.1714 (1.2); 2.1605 (1.3); 2.1473 (1.2); 2.1239 (1.6); 2.1010 (1.6); 2.0899 (1.4); 2.0669 (1.3); 1.8759 (0.6); 1.8641 (0.6); 1.8520 (0.7); 1.8441 (0.9); 1.8200 (0.8); 1.6448 (0.6); 1.6339 (0.9); 1.6243 (0.8); 1.6121 (0.8); 1.6018 (0.7); 0.0080 (1.3); -0.0002 (40.8); -0.0085 (1.1) I.1-519: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.3565 (1.0); 7.3349 (1.0); 7.1982 (0.6); 7.1870 (1.0); 7.1782 (1.0); 7.1702 (0.8); 7.1667 (0.8); 7.1581 (0.6); 7.0990 (0.7); 7.0828 (1.0); 7.0640 (0.8); 7.0508 (0.5); 4.7582 (1.4); 4.7182 (1.6); 4.2737 (1.3); 4.2339 (1.2); 4.1995 (0.7); 4.1596 (0.6); 4.0870 (2.3); 3.9436 (4.0); 3.9370 (3.9); 3.8356 (0.8); 3.8262 (0.9); 3.8157 (0.9); 3.8054 (0.7); 3.3316 (54.4); 2.9487 (16.0); 2.8403 (0.8); 2.8298 (0.8); 2.7997 (1.0); 2.7894 (1.0); 2.7633 (7.3); 2.6755 (0.6); 2.6709 (0.9); 2.6663 (0.6); 2.6555 (0.5); 2.6453 (0.6); 2.5533 (0.9); 2.5409 (0.7); 2.5363 (0.9); 2.5311 (1.4); 2.5243 (2.1); 2.5196 (3.4); 2.5109 (46.9); 2.5064 (99.8); 2.5018 (138.4); 2.4972 (98.6); 2.4927 (45.2); 2.4698 (0.8); 2.4560 (0.8); 2.4515 (0.8); 2.4330 (0.8); 2.4119 (0.7); 2.3994 (0.7); 2.3773 (0.6); 2.3333 (0.8); 2.3286 (1.0); 2.3240 (0.8); 2.2658 (0.7); 2.2542 (0.7); 2.2416 (1.2); 2.2299 (1.1); 2.2002 (1.0); 2.1942 (1.4); 2.1793 (0.9); 2.1676 (0.7); 2.1609 (0.6); 2.1485 (1.0); 2.1244 (0.6); 1.6949 (0.5); 1.6727 (0.6); 1.6556 (0.5); 0.0080 (1.3); -0.0002 (43.1); -0.0085 (1.4) I.1-522: 1 H-NMR (400.0 MHz, CDCl 3 ): δ= 7.3270 (0.8); 7.3239 (1.5); 7.3198 (0.6); 7.3111 (0.9); 7.3065 (3.6); 7.3029 (2.0); 7.2913 (1.3); 7.2879 (3.0); 7.2825 (0.6); 7.2666 (0.6); 7.2658 (0.7); 7.2650 (0.9); 7.2603 (62.9); 7.2553 (1.1); 7.2534 (1.8); 7.2497 (1.0); 7.2408 (0.5); 7.2349 (1.7); 7.2166 (0.6); 7.1601 (2.4); 7.1563 (3.4); 7.1510 (0.8); 7.1395 (2.4); 7.1383 (2.3); 7.1364 (1.9); 7.1096 (28.3); 5.2981 (1.1); 5.2743 (0.5); 4.7065 (1.8); 4.6690 (2.0); 4.1086 (1.8); 4.0711 (1.6); 3.9313 (0.7); 3.9209 (0.7); 3.9108 (1.1); 3.9007 (0.7); 3.8901 (0.7); 3.5138 (0.8); 3.4962 (1.3); 3.4810 (1.3); 3.4788 (1.2); 3.4638 (1.2); 3.4615 (1.3); 3.4467 (1.2); 3.4296 (0.8); 2.7830 (2.0); 2.7657 (4.0); 2.7484 (1.8); 2.4840 (1.3); 2.4725 (1.3); 2.4562 (0.9); 2.4480 (1.5); 2.4366 (2.2); 2.4139 (0.7); 2.4052 (0.9); 2.3908 (1.0); 2.3810 (1.2); 2.3668 (1.2); 2.3383 (0.6); 2.3221 (16.0); 2.1924 (0.7); 2.1792 (0.5); 2.1683 (0.6); 2.1600 (0.8); 2.1551 (0.5); 2.1356 (0.7); 2.0491 (1.5); 2.0277 (1.5); 2.0131 (1.3); 1.9916 (1.3); 1.7359 (0.5); 1.7252 (0.6); 1.7155 (0.6); 1.7028 (0.6); 1.6920 (0.5); 1.5819 (0.8); 0.0079 (0.5); -0.0002 (18.4); -0.0085 (0.5) I.1-525: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.4851 (2.4); 8.4751 (3.2); 8.0299 (2.2); 7.7108 (1.2); 7.6921 (2.4); 7.6763 (1.5); 7.2369 (3.1); 7.2313 (3.1); 7.2188 (4.7); 7.1385 (2.7); 7.1195 (7.1); 7.0959 (7.0); 7.0770 (3.8); 4.6431 (2.2); 4.6051 (2.4); 3.9711 (2.5); 3.9326 (2.3); 3.9028 (2.2); 3.8912 (1.0); 3.6766 (0.8); 3.6666 (1.4); 3.6557 (1.8); 3.6462 (1.8); 3.6367 (1.4); 3.4924 (0.4); 3.4823 (0.3); 3.3991 (3.4); 3.3851 (4.3); 3.3739 (3.4); 3.3322 (138.2); 3.1656 (0.4); 2.8554 (2.8); 2.8375 (5.6); 2.8205 (3.2); 2.6670 (1.1); 2.5019 (178.1); 2.4981 (194.3); 2.4411 (2.0); 2.4306 (2.5); 2.3519 (0.5); 2.3290 (1.8); 2.3252 (1.9); 2.3123 (1.8); 2.2892 (2.0); 2.2737 (16.0); 2.2438 (1.3); 2.2302 (1.4); 2.2198 (1.7); 2.2031 (1.6); 2.1894 (0.9); 2.1786 (0.8); 2.1643 (0.8); 2.0878 (1.4); 2.0648 (1.6); 2.0533 (2.0); 2.0307 (1.3); 2.0069 (0.5); 1.9842 (0.9); 1.9749 (1.0); 1.9636 (1.2); 1.9533 (1.4); 1.9320 (1.2); 1.9128 (0.5); 1.6508 (0.4); 1.6381 (0.9); 1.6279 (1.2); 1.6157 (1.4); 1.6052 (1.4); 1.5965 (1.3); 1.5844 (1.0); 1.5724 (0.6); 1.3557 (0.4); 1.3355 (0.6); 1.2338 (0.5); 1.2245 (0.8); - 0.0006 (1.8); -0.0110 (0.9) I.1-526: 1 H-NMR (400.0 MHz, CDCl3): δ= 7.5085 (0.8); 7.4890 (1.3); 7.4420 (0.9); 7.4230 (1.7); 7.4014 (1.6); 7.3966 (2.1); 7.3565 (1.4); 7.3375 (0.9); 7.2649 (0.6); 7.2615 (37.0); 7.1115 (27.2); 5.3901 (0.6); 4.6910 (1.8); 4.6534 (2.0); 4.1345 (1.8); 4.0969 (1.6); 3.9441 (0.6); 3.9335 (0.7); 3.9234 (1.1); 3.9133 (0.8); 3.9029 (0.7); 3.5347 (0.5); 3.5189 (0.8); 3.5007 (1.3); 3.4853 (1.1); 3.4674 (0.9); 3.4495 (1.0); 3.4347 (1.1); 3.4172 (0.7); 2.8491 (2.0); 2.8314 (3.9); 2.8137 (1.8); 2.5025 (1.3); 2.4912 (1.3); 2.4665 (1.5); 2.4554 (2.0); 2.4371 (0.9); 2.4347 (0.8); 2.4141 (0.8); 2.4104 (1.0); 2.3958 (1.0); 2.3861 (1.1); 2.3719 (1.2); 2.3433 (0.5); 2.3289 (0.6); 2.3185 (16.0); 2.1993 (0.7); 2.1862 (0.5); 2.1753 (0.7); 2.1669 (0.8); 2.1622 (0.5); 2.1426 (0.7); 2.0674 (1.6); 2.0459 (1.6); 2.0313 (1.4); 2.0098 (1.4); 1.7205 (0.6); 1.7110 (0.6); 1.6979 (0.6); 1.6873 (0.5); - 0.0002 (12.3) I.1-527: 1 H-NMR (400.0 MHz, CDCl 3 ): δ= 7.5204 (1.4); 7.2615 (276.4); 7.2548 (0.8); 7.2539 (0.6); 7.2531 (0.6); 7.2114 (1.3); 7.2056 (7.2); 7.1997 (3.2); 7.1896 (5.0); 7.1834 (25.2); 7.1786 (4.8); 7.1650 (14.6); 7.1632 (14.4); 7.1427 (5.0); 7.1407 (4.3); 7.1244 (1.1); 7.1129 (2.0); 7.1067 (1.0); 7.0996 (3.9); 7.0910 (1.7); 7.0877 (2.2); 7.0831 (2.8); 7.0811 (2.9); 7.0732 (3.8); 7.0682 (1.4); 7.0618 (2.2); 7.0569 (4.0); 7.0540 (11.1); 7.0492 (7.2); 7.0472 (7.6); 7.0438 (7.0); 7.0398 (12.2); 7.0354 (3.8); 7.0291 (4.6); 7.0202 (0.8); 6.9974 (1.5); 5.4183 (2.3); 5.2994 (2.3); 4.8484 (4.6); 4.8447 (4.5); 4.8097 (5.2); 4.8060 (5.1); 4.2338 (6.7); 4.1951 (6.0); 3.9321 (1.1); 3.9210 (2.2); 3.9102 (2.8); 3.9002 (3.1); 3.8901 (2.8); 3.8792 (2.3); 3.8681 (1.1); 3.5481 (1.0); 3.5319 (2.7); 3.5140 (5.8); 3.5008 (6.6); 3.4993 (6.6); 3.4862 (5.6); 3.4691 (2.8); 3.4520 (0.9); 2.8266 (8.3); 2.8090 (16.0); 2.7915 (7.0); 2.5917 (4.8); 2.5809 (4.7); 2.5556 (5.5); 2.5447 (5.4); 2.5126 (0.9); 2.4942 (1.2); 2.4907 (1.2); 2.4704 (3.4); 2.4512 (3.1); 2.4477 (2.9); 2.4276 (2.9); 2.4178 (3.5); 2.4030 (4.1); 2.3937 (4.8); 2.3791 (4.8); 2.3749 (1.7); 2.3601 (1.4); 2.3507 (2.1); 2.3362 (2.0); 2.2599 (1.8); 2.2408 (2.7); 2.2361 (1.7); 2.2273 (2.2); 2.2218 (1.8); 2.2167 (2.3); 2.2084 (3.0); 2.2032 (2.0); 2.1979 (1.4); 2.1891 (1.9); 2.1838 (2.4); 2.1649 (1.3); 2.1346 (6.0); 2.1123 (5.9); 2.0984 (5.3); 2.0762 (5.2); 1.8064 (1.7); 1.7951 (1.8); 1.7922 (2.1); 1.7809 (2.3); 1.7716 (2.2); 1.7684 (1.9); 1.7623 (1.8); 1.7590 (2.2); 1.7477 (2.0); 1.7387 (1.6); 1.7356 (1.4); 1.7240 (1.3); 1.4557 (1.2); 0.0080 (2.5); -0.0002 (89.4); - 0.0085 (2.5) I.1-528: 1 H-NMR (400.0 MHz, CDCl3): δ= 7.5213 (1.0); 7.3828 (3.5); 7.3798 (4.2); 7.3779 (4.6); 7.3750 (4.3); 7.3631 (4.3); 7.3602 (4.9); 7.3582 (5.8); 7.3553 (5.1); 7.3210 (6.9); 7.3170 (11.2); 7.3129 (6.0); 7.2712 (1.0); 7.2696 (1.3); 7.2624 (175.4); 7.2566 (1.0); 7.2558 (0.8); 7.2550 (0.5); 7.2542 (0.5); 7.2001 (6.2); 7.1808 (13.4); 7.1614 (8.0); 7.1231 (1.3); 7.1149 (5.3); 7.1122 (8.6); 7.1110 (7.7); 7.1081 (6.1); 7.0981 (4.8); 7.0960 (4.2); 7.0929 (4.8); 7.0918 (5.0); 7.0891 (4.6); 7.0824 (2.9); 7.0797 (3.2); 7.0719 (4.7); 7.0659 (1.6); 7.0603 (2.0); 7.0557 (4.6); 7.0524 (9.6); 7.0455 (9.3); 7.0422 (7.1); 7.0374 (12.5); 7.0289 (5.3); 7.0267 (4.7); 7.0165 (0.9); 7.0099 (0.8); 6.9983 (1.0); 5.4452 (2.4); 4.8476 (4.9); 4.8439 (4.8); 4.8089 (5.5); 4.8051 (5.4); 4.2337 (7.1); 4.1949 (6.3); 3.9411 (1.2); 3.9300 (2.4); 3.9190 (2.9); 3.9084 (3.2); 3.8990 (2.9); 3.8880 (2.5); 3.8770 (1.2); 3.5608 (0.7); 3.5433 (1.7); 3.5267 (3.2); 3.5093 (5.5); 3.4941 (5.5); 3.4797 (5.3); 3.4770 (3.2); 3.4648 (5.3); 3.4478 (3.2); 3.4308 (1.6); 3.4137 (0.7); 2.7917 (8.3); 2.7744 (16.0); 2.7570 (7.1); 2.5937 (5.1); 2.5828 (5.0); 2.5576 (5.9); 2.5467 (5.7); 2.5197 (1.0); 2.5012 (1.4); 2.4977 (1.2); 2.4780 (3.6); 2.4582 (3.3); 2.4547 (3.0); 2.4349 (3.0); 2.4222 (3.7); 2.4075 (4.4); 2.3981 (5.2); 2.3836 (5.2); 2.3794 (1.8); 2.3647 (1.4); 2.3551 (2.3); 2.3408 (2.3); 2.2730 (1.9); 2.2539 (3.0); 2.2491 (1.8); 2.2404 (2.3); 2.2350 (1.9); 2.2298 (2.4); 2.2214 (3.2); 2.2163 (2.1); 2.2110 (1.4); 2.2023 (2.0); 2.1970 (2.5); 2.1782 (1.3); 2.1259 (6.5); 2.1034 (6.3); 2.0898 (5.6); 2.0673 (5.5); 2.0066 (1.4); 1.8159 (2.0); 1.8045 (2.3); 1.8017 (2.6); 1.7905 (3.1); 1.7810 (3.5); 1.7779 (3.3); 1.7718 (3.4); 1.7687 (3.9); 1.7667 (3.7); 1.7596 (3.3); 1.7574 (3.5); 1.7482 (2.7); 1.7451 (2.4); 1.7336 (2.0); 0.0080 (1.8); 0.0064 (0.6); 0.0056 (0.7); 0.0047 (0.8); 0.0039 (1.1); 0.0023 (2.6); -0.0002 (58.3); -0.0051 (0.7); -0.0059 (0.5); -0.0085 (1.6) I.1-529: 1 H-NMR (400.0 MHz, CDCl 3 ): δ= 7.5205 (0.8); 7.3114 (0.6); 7.3010 (8.5); 7.2802 (11.9); 7.2617 (146.4); 7.2117 (0.8); 7.1892 (6.7); 7.1833 (12.8); 7.1773 (10.3); 7.1710 (3.9); 7.1565 (6.0); 7.1502 (4.0); 7.1228 (0.8); 7.1107 (1.7); 7.0979 (3.1); 7.0866 (1.8); 7.0797 (2.6); 7.0737 (3.5); 7.0620 (1.9); 7.0553 (10.4); 7.0488 (6.8); 7.0447 (6.1); 7.0414 (10.1); 7.0367 (2.9); 7.0307 (3.6); 7.0221 (0.8); 6.9977 (0.9); 5.4829 (2.2); 4.8556 (4.1); 4.8522 (4.1); 4.8168 (4.6); 4.8134 (4.6); 4.2473 (6.0); 4.2086 (5.3); 3.9505 (1.0); 3.9395 (1.9); 3.9286 (2.4); 3.9172 (2.6); 3.9083 (2.4); 3.8973 (2.0); 3.8864 (1.0); 3.5808 (0.5); 3.5634 (1.2); 3.5469 (2.7); 3.5294 (4.7); 3.5209 (2.0); 3.5137 (4.5); 3.5039 (4.3); 3.4965 (2.2); 3.4884 (4.5); 3.4713 (2.6); 3.4543 (1.2); 3.4374 (0.5); 2.9322 (8.1); 2.9149 (16.0); 2.8976 (7.0); 2.6153 (4.1); 2.6047 (4.0); 2.5791 (4.7); 2.5685 (4.5); 2.5306 (0.9); 2.5115 (1.2); 2.5077 (1.1); 2.4878 (3.1); 2.4688 (2.8); 2.4645 (2.5); 2.4459 (2.6); 2.4299 (2.8); 2.4153 (3.3); 2.4058 (3.9); 2.3914 (4.0); 2.3872 (1.5); 2.3724 (1.1); 2.3628 (1.8); 2.3485 (1.8); 2.2856 (1.5); 2.2666 (2.4); 2.2618 (1.4); 2.2529 (1.8); 2.2476 (1.4); 2.2425 (1.9); 2.2340 (2.7); 2.2289 (1.6); 2.2237 (1.0); 2.2148 (1.5); 2.2097 (2.0); 2.1908 (1.0); 2.1331 (5.0); 2.1102 (4.9); 2.0970 (4.4); 2.0741 (4.2); 1.8267 (1.4); 1.8127 (1.8); 1.8022 (2.2); 1.7922 (2.1); 1.7795 (2.1); 1.7686 (2.0); 1.7590 (1.7); 1.7561 (1.6); 1.7444 (1.7); 1.7063 (1.9); 0.0079 (1.6); -0.0002 (46.6); -0.0085 (1.2) I.1-535: 1 H-NMR (400.0 MHz, CDCl3): δ= 7.2622 (28.4); 7.1141 (19.2); 6.8093 (1.4); 6.7878 (1.9); 6.6949 (0.7); 6.6899 (1.4); 6.6824 (1.7); 6.6777 (1.8); 6.6735 (1.3); 4.7194 (1.1); 4.6819 (1.2); 4.1171 (1.1); 4.0795 (1.0); 3.9428 (0.7); 3.8604 (15.8); 3.8581 (16.0); 3.4772 (0.7); 3.4620 (0.9); 3.4444 (0.9); 3.4297 (0.7); 2.7305 (1.1); 2.7130 (2.3); 2.6954 (1.0); 2.5025 (0.8); 2.4907 (0.8); 2.4858 (0.6); 2.4663 (1.3); 2.4547 (0.8); 2.4361 (0.5); 2.4219 (0.6); 2.4119 (0.7); 2.3979 (0.6); 2.3232 (9.9); 2.0777 (0.9); 2.0565 (0.9); 2.0416 (0.8); 2.0204 (0.8); - 0.0002 (5.0) I.1-536: 1 H-NMR (400.0 MHz, CDCl3): δ= 7.2635 (11.5); 7.2470 (0.6); 7.2426 (0.6); 7.2281 (0.8); 7.2267 (0.8); 7.2237 (0.9); 7.2079 (0.7); 7.2035 (0.7); 7.1060 (0.9); 7.1016 (0.9); 7.0873 (1.2); 7.0833 (1.5); 7.0711 (0.5); 7.0583 (1.0); 7.0389 (1.3); 7.0307 (2.0); 7.0286 (1.2); 7.0219 (1.5); 7.0204 (1.5); 7.0155 (0.6); 7.0113 (0.9); 6.9205 (0.8); 6.9178 (0.9); 6.9020 (1.3); 6.8993 (1.6); 6.8829 (1.7); 6.8808 (1.8); 6.8618 (1.2); 4.8305 (0.8); 4.8270 (0.8); 4.7917 (0.9); 4.7882 (0.8); 4.2146 (1.1); 4.1758 (1.0); 3.9003 (0.5); 3.8983 (0.5); 3.8297 (0.8); 3.8251 (16.0); 3.4764 (1.2); 3.4719 (0.9); 3.4629 (1.0); 3.4585 (1.2); 2.8261 (1.4); 2.8094 (2.7); 2.7927 (1.3); 2.5611 (0.8); 2.5500 (0.8); 2.5254 (0.9); 2.5143 (0.9); 2.4612 (0.6); 2.4418 (0.5); 2.4062 (0.6); 2.3916 (0.7); 2.3821 (0.8); 2.3676 (0.8); 2.1896 (0.5); 2.0897 (1.0); 2.0672 (1.0); 2.0540 (0.9); 2.0314 (0.8); - 0.0002 (3.6) I.1-537: 1 H-NMR (400.0 MHz, CDCl 3 ): δ= 7.2619 (50.3); 7.0993 (0.6); 7.0723 (0.6); 7.0567 (0.7); 7.0528 (1.5); 7.0459 (1.4); 7.0426 (1.1); 7.0379 (1.9); 7.0294 (0.8); 7.0274 (0.7); 6.8156 (1.4); 6.7940 (2.1); 6.7121 (0.8); 6.7070 (1.5); 6.6996 (1.8); 6.6949 (1.9); 6.6906 (1.3); 4.8496 (0.8); 4.8461 (0.7); 4.8110 (0.8); 4.8073 (0.8); 4.2323 (1.1); 4.1936 (1.0); 3.9200 (0.6); 3.8672 (16.0); 3.8622 (16.0); 3.5004 (1.2); 3.4971 (1.0); 3.4860 (1.0); 3.4825 (1.2); 2.7612 (1.2); 2.7438 (2.5); 2.7264 (1.1); 2.5867 (0.8); 2.5756 (0.8); 2.5506 (0.9); 2.5395 (0.9); 2.4867 (0.6); 2.4668 (0.6); 2.4635 (0.5); 2.4442 (0.5); 2.4332 (0.6); 2.4185 (0.7); 2.4090 (0.8); 2.3946 (0.9); 2.2253 (0.5); 2.1335 (1.0); 2.1114 (0.9); 2.0975 (0.8); 2.0753 (0.8); 0.0079 (0.5); -0.0002 (16.3) I.1-542: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 7.9699 (0.5); 7.0570 (0.6); 7.0536 (0.6); 4.7310 (0.7); 4.6912 (0.8); 4.2321 (0.9); 4.1924 (0.8); 3.7806 (0.5); 3.5759 (16.0); 3.3644 (17.6); 3.0358 (0.7); 3.0263 (0.8); 3.0216 (0.8); 3.0122 (0.7); 2.5108 (7.3); 2.5062 (14.7); 2.5016 (20.6); 2.4970 (14.4); 2.4924 (6.3); 2.4762 (0.8); 2.4646 (0.7); 2.3579 (0.5); 2.3383 (0.5); 2.3050 (1.4); 2.2865 (3.0); 2.2740 (0.6); 2.2676 (1.6); 2.2638 (0.8); 2.2501 (0.6); 2.1890 (0.8); 2.1676 (0.8); 2.1541 (0.7); 2.1325 (0.7); 1.6347 (1.2); 1.6164 (1.7); 1.5984 (1.0); -0.0002 (0.7) I.1-545: 1 H-NMR (400.0 MHz, CDCl3): δ= 7.2918 (1.9); 7.2863 (1.1); 7.2749 (1.0); 7.2694 (2.9); 7.2626 (24.2); 7.1681 (7.4); 7.1629 (2.5); 7.1508 (2.3); 7.1445 (1.1); 7.1172 (25.7); 5.4808 (0.6); 5.2982 (7.9); 4.6998 (1.8); 4.6622 (2.0); 4.1443 (1.8); 4.1067 (1.6); 3.9543 (0.6); 3.9436 (0.8); 3.9334 (1.0); 3.9235 (0.8); 3.9128 (0.7); 3.4984 (0.8); 3.4806 (1.4); 3.4650 (1.6); 3.4476 (1.6); 3.4325 (1.2); 3.4153 (0.8); 2.8928 (2.3); 2.8753 (4.6); 2.8579 (2.0); 2.5212 (1.2); 2.5097 (1.5); 2.4850 (2.3); 2.4737 (1.4); 2.4648 (0.9); 2.4621 (0.8); 2.4419 (0.7); 2.4293 (0.8); 2.4151 (1.0); 2.4051 (1.1); 2.3911 (1.1); 2.3623 (0.5); 2.3213 (16.0); 2.2209 (0.7); 2.1968 (0.6); 2.1884 (0.8); 2.1836 (0.5); 2.1640 (0.7); 2.0838 (1.5); 2.0620 (1.5); 2.0476 (1.3); 2.0258 (1.3); 1.7488 (0.6); 1.7390 (0.6); 1.7262 (0.6); 1.7157 (0.5); -0.0002 (8.4) I.1-557: 1 H-NMR (400.1 MHz, d6-DMSO): δ= 19.0524 (0.8); 18.7806 (0.8); 18.5751 (0.8); 17.5432 (0.8); 14.8014 (0.8); 10.4423 (0.8); 8.3532 (0.8); 8.3495 (0.8); 8.2886 (4.0); 8.2482 (4.8); 8.2443 (4.5); 8.2005 (0.9); 8.1750 (0.8); 7.3607 (1.9); 7.3373 (3.9); 7.3315 (2.4); 7.3147 (1.9); 7.3076 (1.3); 7.2734 (1.6); 7.2555 (1.8); 7.2498 (3.1); 7.2442 (2.1); 7.2318 (1.2); 7.2262 (2.2); 7.2016 (1.3); 7.1736 (4.7); 7.1569 (9.0); 7.1515 (8.5); 7.1356 (6.5); 7.1177 (1.9); 7.1112 (2.5); 7.1057 (1.5); 7.0934 (2.4); 7.0876 (4.4); 7.0820 (2.4); 7.0729 (1.8); 7.0643 (2.0); 7.0592 (1.4); 7.0000 (1.1); 6.9953 (1.3); 6.9780 (1.7); 6.9719 (3.2); 6.9666 (1.9); 6.9482 (2.2); 6.9205 (4.9); 6.9150 (6.0); 6.8985 (10.1); 6.8820 (5.4); 6.8758 (4.0); 5.7681 (0.8); 4.2471 (1.5); 4.2393 (1.3); 3.9892 (1.9); 3.9811 (1.8); 3.6110 (0.8); 3.5256 (0.9); 3.5089 (1.4); 3.4775 (1.0); 3.4510 (0.9); 3.4449 (0.8); 3.4334 (1.0); 3.4094 (3.8); 3.3730 (3.7); 3.3611 (7.2); 3.3101 (3466.6); 3.2608 (8.4); 3.2382 (2.1); 3.2123 (2.8); 3.1903 (1.0); 3.1687 (6.2); 3.0134 (0.8); 2.9895 (0.9); 2.6963 (1.3); 2.6781 (6.0); 2.6739 (9.7); 2.6691 (12.7); 2.6644 (10.0); 2.6599 (6.4); 2.6508 (1.4); 2.6441 (1.5); 2.5994 (2.0); 2.5954 (2.2); 2.5678 (1.8); 2.5553 (3.6); 2.5505 (4.0); 2.5462 (3.4); 2.5420 (2.1); 2.5226 (18.8); 2.5178 (26.4); 2.5092 (663.4); 2.5046 (1486.8); 2.5001 (2112.1); 2.4955 (1515.8); 2.4909 (706.4); 2.4550 (5.1); 2.4504 (5.3); 2.4458 (4.2); 2.4349 (1.7); 2.4188 (1.4); 2.4161 (1.4); 2.4064 (2.0); 2.3969 (1.3); 2.3570 (0.8); 2.3363 (4.0); 2.3315 (8.6); 2.3269 (12.4); 2.3223 (8.9); 2.3178 (4.3); 2.2569 (0.9); 2.2425 (1.1); 2.2194 (2.3); 2.2059 (1.9); 2.1976 (2.2); 2.1893 (1.7); 2.1785 (2.2); 2.1644 (2.3); 2.1520 (3.7); 2.1351 (3.8); 2.1170 (2.8); 2.0971 (1.4); 2.0712 (5.2); 1.2391 (1.6); 1.2162 (13.6); 1.1991 (13.5); 1.1741 (16.0); 1.1568 (15.6); 0.1460 (1.7); 0.0116 (2.7); 0.0082 (10.6); 0.0000 (384.6) I.1-561: 1 H-NMR (400.0 MHz, CDCl 3 ): δ= 7.2620 (36.0); 7.1364 (0.7); 7.1176 (29.3); 7.0989 (1.5); 7.0942 (0.8); 7.0779 (0.7); 6.8360 (0.5); 6.8295 (0.6); 6.8272 (0.7); 6.8152 (0.8); 6.8071 (2.4); 6.7863 (1.5); 6.7842 (1.3); 6.7763 (0.7); 6.7604 (0.9); 6.7540 (0.6); 5.3835 (0.5); 5.2986 (1.5); 4.7020 (1.8); 4.6645 (2.0); 4.1351 (1.8); 4.0975 (1.6); 3.9384 (0.6); 3.9279 (0.8); 3.9177 (1.1); 3.9076 (0.8); 3.8972 (0.7); 3.4539 (0.8); 3.4362 (1.2); 3.4257 (0.6); 3.4207 (1.2); 3.4086 (1.1); 3.4034 (0.6); 3.3933 (1.2); 3.3761 (0.7); 2.7847 (1.4); 2.7673 (2.7); 2.7499 (1.3); 2.4974 (1.5); 2.4860 (1.3); 2.4731 (0.9); 2.4613 (1.5); 2.4499 (2.1); 2.4307 (0.7); 2.4188 (0.8); 2.4046 (1.0); 2.3946 (1.1); 2.3805 (1.1); 2.3518 (0.5); 2.3378 (0.6); 2.3245 (16.0); 2.2054 (0.8); 2.1922 (0.6); 2.1812 (0.7); 2.1728 (0.9); 2.1681 (0.6); 2.1533 (0.5); 2.1485 (0.7); 2.0804 (1.6); 2.0590 (1.6); 2.0442 (1.4); 2.0228 (1.4); 1.7479 (0.6); 1.7379 (0.6); 1.7253 (0.6); 1.7148 (0.5); -0.0002 (10.9) I.1-562: 1 H-NMR (400.0 MHz, CDCl3): δ= 7.3829 (0.8); 7.3803 (1.0); 7.3782 (1.0); 7.3756 (0.9); 7.3632 (1.0); 7.3604 (1.1); 7.3584 (1.3); 7.3558 (1.1); 7.3038 (1.5); 7.2997 (2.5); 7.2955 (1.4); 7.2612 (38.6); 7.1921 (1.4); 7.1728 (2.9); 7.1533 (1.7); 7.1151 (28.1); 7.0899 (1.6); 7.0708 (1.0); 5.3541 (0.5); 5.2984 (1.8); 4.7062 (1.5); 4.6687 (1.7); 4.1309 (1.6); 4.0934 (1.5); 3.9385 (0.6); 3.9281 (0.8); 3.9179 (0.6); 3.4928 (0.6); 3.4752 (0.9); 3.4596 (0.8); 3.4428 (0.6); 3.4263 (0.7); 3.4113 (0.8); 3.3941 (0.6); 2.7567 (1.8); 2.7393 (3.4); 2.7220 (1.6); 2.5058 (0.9); 2.4942 (0.8); 2.4871 (0.7); 2.4692 (1.3); 2.4584 (1.0); 2.4441 (0.6); 2.4349 (0.6); 2.4206 (0.6); 2.4107 (0.7); 2.3965 (0.7); 2.3235 (16.0); 2.1805 (0.5); 2.0748 (0.8); 2.0534 (0.8); 2.0387 (0.7); 2.0174 (0.6); -0.0002 (12.7) I.1-565: 1 H-NMR (400.0 MHz, CDCl3): δ= 7.2621 (36.5); 7.1409 (0.6); 7.1188 (22.5); 6.2271 (0.6); 4.7750 (1.8); 4.7375 (2.0); 4.0818 (1.8); 4.0444 (1.6); 3.9702 (0.5); 3.9612 (0.8); 3.9511 (0.9); 3.9404 (0.8); 3.3028 (0.6); 3.2857 (1.0); 3.2706 (1.0); 3.2536 (0.6); 3.2473 (1.0); 3.2329 (1.0); 3.2163 (0.6); 2.5482 (1.1); 2.5359 (1.5); 2.5127 (2.1); 2.5004 (1.3); 2.4919 (1.0); 2.4700 (0.6); 2.4308 (0.7); 2.4182 (0.9); 2.4063 (1.0); 2.3936 (1.3); 2.3888 (2.5); 2.3718 (4.4); 2.3636 (1.0); 2.3546 (2.5); 2.3259 (1.8); 2.3190 (16.0); 2.2092 (0.7); 2.1846 (0.8); 2.1805 (1.6); 2.1770 (1.0); 2.1726 (0.6); 2.1598 (1.5); 2.1523 (0.8); 2.1449 (1.2); 2.1242 (1.1); 1.8348 (0.6); 1.8269 (0.7); 1.8177 (2.4); 1.8012 (3.1); 1.7940 (1.2); 1.7840 (2.4); 1.7674 (0.6); 1.4319 (0.6); 1.2216 (1.2); -0.0002 (10.7) I.1-569: 1 H-NMR (400.0 MHz, CDCl 3 ): δ= 7.5189 (10.3); 7.3794 (6.3); 7.3746 (6.5); 7.3602 (7.2); 7.3554 (7.5); 7.3335 (1.2); 7.3088 (1.3); 7.2937 (2.1); 7.2898 (2.1); 7.2858 (2.5); 7.2600 (2050.6); 7.2533 (6.5); 7.2524 (5.5); 7.2516 (5.9); 7.2500 (2.9); 7.2492 (2.8); 7.2484 (2.1); 7.2477 (2.0); 7.2453 (1.5); 7.2445 (1.3); 7.2332 (1.5); 7.2317 (1.2); 7.2099 (3.8); 7.1729 (5.4); 7.1538 (14.4); 7.1347 (11.8); 7.1254 (8.6); 7.1206 (9.0); 7.1117 (2.5); 7.1063 (4.4); 7.0990 (3.6); 7.0872 (1.7); 7.0822 (2.4); 7.0746 (3.7); 7.0561 (11.8); 7.0495 (6.4); 7.0458 (6.9); 7.0430 (9.1); 7.0374 (3.0); 7.0317 (3.8); 6.9960 (10.6); 5.4251 (2.2); 4.8537 (3.7); 4.8112 (4.6); 4.2458 (5.6); 4.2078 (5.0); 3.9341 (1.8); 3.9228 (2.3); 3.9130 (2.5); 3.9032 (2.4); 3.8918 (1.9); 3.5566 (2.3); 3.5485 (2.0); 3.5387 (5.1); 3.5315 (4.9); 3.5236 (4.9); 3.5160 (5.1); 3.5059 (2.3); 3.4991 (2.5); 3.0103 (7.7); 2.9929 (16.0); 2.9755 (7.2); 2.6007 (3.8); 2.5901 (4.0); 2.5646 (4.6); 2.5537 (4.4); 2.5118 (1.2); 2.4887 (3.1); 2.4699 (2.5); 2.4454 (2.5); 2.4286 (2.9); 2.4141 (3.4); 2.4045 (4.0); 2.3901 (4.0); 2.3707 (1.2); 2.3616 (1.9); 2.3473 (2.1); 2.2673 (1.6); 2.2480 (2.3); 2.2346 (1.7); 2.2241 (1.9); 2.2153 (2.3); 2.2106 (1.7); 2.1967 (1.9); 2.1908 (2.0); 2.1720 (1.2); 2.1325 (5.0); 2.1099 (4.9); 2.0963 (4.3); 2.0737 (4.3); 1.8045 (1.8); 1.7949 (1.9); 1.7844 (2.0); 1.7692 (2.0); 1.7600 (1.9); 1.7505 (1.5); 1.5999 (9.2); 1.4632 (1.9); 0.1458 (2.2); 0.0110 (2.5); 0.0079 (19.2); 0.0062 (6.6); 0.0054 (7.6); 0.0046 (9.0); 0.0037 (12.3); - 0.0002 (674.6); -0.0028 (35.2); -0.0044 (13.0); -0.0052 (7.7); -0.0061 (5.8); -0.0069 (5.0); -0.0085 (19.7); -0.0108 (2.6); -0.0117 (2.2); -0.0124 (2.1); -0.0132 (1.4); -0.0141 (1.3); -0.0148 (1.6); -0.0172 (1.1); - 0.0196 (1.1); -0.0504 (1.7); -0.1495 (1.7) I.1-570: 1 H-NMR (400.0 MHz, CDCl3): δ= 7.5194 (0.5); 7.2606 (101.1); 7.1825 (0.8); 7.1751 (0.6); 7.1672 (0.8); 7.1599 (8.6); 7.1547 (5.8); 7.1377 (0.6); 7.1300 (0.8); 7.1163 (28.1); 6.9965 (0.5); 5.2827 (0.6); 4.7029 (1.8); 4.6654 (2.0); 4.1391 (1.8); 4.1016 (1.6); 3.9416 (0.6); 3.9316 (0.7); 3.9211 (1.1); 3.9105 (0.7); 3.9006 (0.7); 3.4977 (0.8); 3.4794 (1.3); 3.4641 (1.1); 3.4585 (0.6); 3.4462 (0.7); 3.4407 (1.1); 3.4259 (1.2); 3.4086 (0.7); 2.7889 (2.3); 2.7712 (4.6); 2.7536 (2.0); 2.4969 (1.3); 2.4855 (1.3); 2.4688 (0.9); 2.4608 (1.5); 2.4493 (2.2); 2.4264 (0.8); 2.4210 (0.9); 2.4066 (1.0); 2.3968 (1.2); 2.3825 (1.1); 2.3397 (0.5); 2.3237 (16.0); 2.1983 (0.7); 2.1851 (0.5); 2.1742 (0.7); 2.1657 (0.8); 2.1610 (0.6); 2.1415 (0.7); 2.0759 (1.6); 2.0547 (1.5); 2.0398 (1.4); 2.0186 (1.4); 1.7357 (0.5); 1.7252 (0.6); 1.7153 (0.6); 1.7025 (0.6); 1.6919 (0.5); 0.0080 (1.0); -0.0002 (34.0); -0.0085 (0.9) I.1-572: 1 H-NMR (400.0 MHz, CDCl 3 ): δ= 7.7562 (2.0); 7.6093 (4.5); 7.2618 (40.2); 7.1161 (25.1); 4.6782 (1.7); 4.6406 (2.0); 4.1609 (1.5); 4.1233 (1.3); 3.9619 (0.6); 3.9514 (0.7); 3.9412 (1.0); 3.9311 (0.7); 3.9206 (0.6); 3.5227 (0.8); 3.5042 (1.1); 3.4887 (1.0); 3.4705 (0.8); 3.4521 (0.9); 3.4370 (1.0); 3.4191 (0.7); 2.9325 (1.8); 2.9146 (3.7); 2.8967 (1.6); 2.5189 (1.2); 2.5075 (1.2); 2.4827 (1.6); 2.4713 (1.4); 2.4618 (0.8); 2.4402 (0.8); 2.4197 (1.2); 2.4055 (0.8); 2.3959 (0.9); 2.3816 (0.9); 2.3174 (16.0); 2.2195 (0.6); 2.1957 (0.6); 2.1871 (0.7); 2.1630 (0.6); 2.0839 (1.5); 2.0625 (1.4); 2.0477 (1.3); 2.0262 (1.3); 1.7243 (0.5); 1.7150 (0.5); 1.7012 (0.5); -0.0002 (8.8) I.1-573: 1 H-NMR (400.0 MHz, CDCl 3 ): δ= 7.7604 (6.9); 7.6337 (16.0); 7.5227 (0.6); 7.2637 (122.0); 7.2603 (2.2); 7.2595 (1.6); 7.2586 (1.3); 7.2578 (1.0); 7.2570 (0.8); 7.2562 (0.7); 7.2554 (0.6); 7.2546 (0.5); 7.1244 (0.9); 7.1151 (1.3); 7.1086 (1.3); 7.0998 (3.1); 7.0873 (2.4); 7.0849 (2.2); 7.0810 (2.5); 7.0748 (5.1); 7.0665 (1.6); 7.0647 (1.6); 7.0630 (1.8); 7.0560 (7.6); 7.0480 (9.9); 7.0452 (6.2); 7.0392 (8.2); 7.0322 (3.1); 7.0286 (4.3); 7.0174 (0.8); 7.0109 (0.5); 6.9996 (0.6); 5.6265 (1.9); 4.8452 (4.1); 4.8416 (4.0); 4.8065 (4.6); 4.8029 (4.5); 4.2410 (5.8); 4.2023 (5.2); 3.9567 (0.9); 3.9456 (1.9); 3.9347 (2.4); 3.9240 (2.7); 3.9146 (2.5); 3.9037 (2.0); 3.8927 (1.0); 3.6128 (0.6); 3.5949 (1.6); 3.5790 (2.7); 3.5607 (4.2); 3.5452 (3.6); 3.5313 (1.7); 3.5272 (1.9); 3.5133 (3.0); 3.4980 (3.6); 3.4808 (2.6); 3.4637 (1.3); 3.4466 (0.7); 2.9777 (4.6); 2.9583 (7.7); 2.9435 (3.5); 2.9401 (3.6); 2.6155 (4.2); 2.6046 (4.2); 2.5792 (4.8); 2.5684 (4.7); 2.5128 (0.8); 2.4935 (1.0); 2.4900 (1.0); 2.4699 (3.0); 2.4504 (2.8); 2.4469 (2.7); 2.4274 (2.8); 2.4222 (3.1); 2.4074 (3.4); 2.3981 (4.1); 2.3836 (4.1); 2.3793 (1.4); 2.3645 (1.0); 2.3551 (1.8); 2.3408 (1.7); 2.2809 (1.6); 2.2618 (2.6); 2.2573 (1.6); 2.2484 (2.0); 2.2428 (1.6); 2.2379 (2.2); 2.2294 (2.9); 2.2244 (1.8); 2.2190 (1.2); 2.2102 (1.7); 2.2051 (2.3); 2.1862 (1.2); 2.1495 (5.4); 2.1270 (5.3); 2.1132 (4.7); 2.0908 (4.6); 1.8044 (1.3); 1.7931 (1.5); 1.7903 (1.7); 1.7793 (1.9); 1.7699 (1.9); 1.7666 (1.6); 1.7604 (1.5); 1.7572 (1.9); 1.7461 (1.7); 1.7370 (1.3); 1.7339 (1.2); 1.7224 (1.1); 0.0080 (1.1); 0.0023 (1.5); -0.0002 (38.7); - 0.0050 (0.7); -0.0059 (0.6); -0.0067 (0.5); -0.0085 (1.2) I.1-594: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.3935 (2.8); 8.3733 (3.0); 7.2803 (1.2); 7.2622 (3.4); 7.2500 (1.5); 7.2446 (4.4); 7.2262 (8.3); 7.2177 (15.8); 7.2091 (3.4); 7.1851 (2.7); 7.1581 (5.3); 7.1379 (9.8); 7.1042 (5.7); 7.0837 (7.2); 7.0634 (2.7); 4.6179 (1.8); 4.5803 (2.0); 4.4744 (0.8); 4.4607 (1.0); 4.4490 (1.0); 4.4208 (0.9); 3.9881 (1.9); 3.9499 (1.6); 3.8788 (1.7); 3.8411 (1.5); 3.6314 (9.1); 3.5654 (2.4); 3.1661 (2.4); 3.0799 (1.2); 3.0557 (1.5); 3.0465 (1.4); 2.8363 (1.8); 2.8101 (2.0); 2.8017 (1.5); 2.7767 (1.4); 2.6760 (1.4); 2.6713 (1.9); 2.6667 (1.3); 2.5983 (1.3); 2.5780 (3.8); 2.5589 (4.0); 2.5392 (1.7); 2.5248 (6.7); 2.5201 (9.1); 2.5114 (116.1); 2.5068 (251.5); 2.5022 (347.2); 2.4976 (240.9); 2.4931 (107.4); 2.4721 (1.7); 2.4611 (3.1); 2.3336 (1.4); 2.3291 (2.0); 2.3243 (1.5); 2.2986 (0.7); 2.2795 (0.8); 2.2578 (1.5); 2.2374 (1.8); 2.2140 (1.0); 2.1844 (1.3); 2.1714 (1.6); 2.1606 (1.7); 2.1472 (1.9); 2.1293 (0.9); 2.1159 (2.7); 2.1049 (1.8); 2.0935 (1.2); 2.0815 (1.8); 2.0748 (1.1); 2.0589 (1.0); 1.8439 (0.7); 1.8198 (0.6); 1.7689 (0.7); 1.7364 (0.8); 1.7125 (0.7); 1.6465 (0.7); 1.6367 (0.8); 1.3732 (1.0); 1.3552 (1.2); 1.3321 (0.6); 1.2368 (1.5); 1.1794 (6.8); 1.1761 (7.3); 1.1605 (14.4); 1.1571 (16.0); 1.1414 (6.5); 1.1381 (6.8); -0.0002 (6.9) I.2-1: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.5740 (0.6); 8.5594 (1.2); 8.5448 (0.6); 7.3984 (0.5); 7.3921 (5.0); 7.3870 (1.7); 7.3759 (2.0); 7.3707 (7.3); 7.3645 (0.9); 7.2835 (0.8); 7.2774 (5.5); 7.2721 (1.6); 7.2609 (1.4); 7.2558 (3.8); 4.2738 (3.2); 4.2589 (3.1); 3.5265 (1.3); 3.5043 (2.2); 3.5025 (2.3); 3.4804 (2.0); 3.4091 (4.6); 3.3804 (2.1); 3.3655 (2.1); 3.3563 (1.4); 3.3414 (1.5); 3.1637 (0.6); 3.1600 (0.8); 3.1488 (0.6); 3.1446 (0.8); 3.1417 (0.9); 3.1378 (0.6); 3.1264 (0.8); 3.0189 (0.7); 2.9995 (0.8); 2.9857 (1.9); 2.9662 (1.9); 2.9467 (1.8); 2.9286 (1.8); 2.9134 (0.7); 2.8953 (0.7); 2.5236 (0.6); 2.5189 (0.8); 2.5103 (11.6); 2.5057 (25.6); 2.5011 (36.1); 2.4964 (24.8); 2.4919 (11.0); 2.4796 (0.6); 2.4608 (2.4); 2.4393 (3.5); 2.4217 (2.3); 2.3987 (0.6); 1.8499 (0.8); 1.8329 (1.0); 1.8158 (0.8); 0.8216 (10.5); 0.8057 (16.0); 0.7898 (10.2); -0.0002 (8.2) I.2-11: 1 H-NMR (400.0 MHz, CDCl3): δ= 8.5586 (1.3); 8.5561 (1.5); 8.5543 (1.5); 8.5519 (1.3); 8.5462 (1.3); 8.5438 (1.6); 8.5420 (1.5); 8.5396 (1.3); 7.7246 (1.3); 7.7201 (1.3); 7.7054 (2.4); 7.7010 (2.4); 7.6862 (1.6); 7.6818 (1.5); 7.5194 (1.0); 7.4757 (0.6); 7.4692 (5.2); 7.4644 (1.7); 7.4529 (1.8); 7.4479 (6.1); 7.4415 (0.6); 7.2857 (2.3); 7.2742 (0.5); 7.2726 (0.7); 7.2661 (3.9); 7.2654 (4.0); 7.2645 (4.6); 7.2606 (162.9); 7.2564 (2.2); 7.2556 (1.5); 7.2547 (1.0); 7.2540 (0.8); 7.2531 (0.7); 7.2523 (0.7); 7.2515 (0.7); 7.2499 (1.0); 7.2485 (1.3); 7.2475 (1.3); 7.2460 (1.3); 7.2443 (1.1); 7.2421 (1.3); 7.2405 (1.1); 7.2396 (1.1); 7.2299 (1.1); 7.2270 (1.1); 7.2105 (1.4); 7.1814 (4.0); 7.1799 (4.4); 7.1595 (3.9); 7.1579 (3.4); 7.1064 (0.8); 6.9965 (0.9); 4.6177 (5.4); 4.6060 (5.3); 4.1966 (2.2); 4.1773 (2.4); 4.1724 (2.7); 4.1531 (2.9); 3.9960 (2.7); 3.9744 (3.2); 3.9718 (2.6); 3.9501 (2.2); 3.3318 (1.2); 3.3099 (1.4); 3.2895 (1.2); 3.2672 (0.5); 3.0280 (2.1); 3.0056 (1.7); 2.9857 (3.2); 2.9633 (3.0); 2.8681 (3.3); 2.8445 (3.0); 2.8257 (2.0); 2.8021 (1.9); 2.3262 (16.0); 1.6273 (3.2); 0.0080 (1.8); -0.0002 (70.3); -0.0085 (2.0) I.2-12: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.4468 (0.5); 7.1785 (1.9); 7.1732 (0.6); 7.1620 (0.7); 7.1566 (2.3); 6.8903 (2.8); 6.8850 (0.8); 6.8738 (0.7); 6.8685 (2.4); 4.2122 (1.4); 4.1976 (1.3); 3.7255 (16.0); 3.5129 (0.6); 3.4906 (0.9); 3.4890 (1.0); 3.4669 (0.8); 3.3730 (0.8); 3.3579 (0.8); 3.3490 (0.6); 3.3339 (0.6); 2.9843 (0.8); 2.9649 (0.8); 2.9462 (0.8); 2.9281 (0.8); 2.5100 (3.8); 2.5054 (8.3); 2.5008 (11.6); 2.4962 (8.1); 2.4916 (3.6); 2.4447 (1.1); 2.4327 (1.1); 2.4222 (1.0); 2.4137 (1.1); 0.8219 (4.6); 0.8107 (4.8); 0.8053 (4.7); 0.7941 (4.5); -0.0002 (1.3) I.2-14: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.5422 (0.9); 8.5280 (1.7); 8.5136 (0.9); 7.3424 (2.1); 7.3385 (1.1); 7.3298 (1.4); 7.3236 (4.5); 7.3215 (3.9); 7.3152 (1.0); 7.3058 (5.5); 7.2543 (7.0); 7.2464 (2.5); 7.2397 (4.5); 7.2348 (3.9); 7.2264 (1.1); 7.2228 (1.0); 4.2935 (3.8); 4.2902 (3.8); 4.2788 (3.8); 4.2756 (3.7); 3.8969 (0.9); 3.5315 (1.8); 3.5077 (3.4); 3.4855 (2.7); 3.3921 (2.4); 3.3771 (2.8); 3.3680 (1.8); 3.3530 (2.0); 3.1902 (0.5); 3.1750 (0.7); 3.1709 (1.0); 3.1683 (1.2); 3.1559 (1.0); 3.1528 (1.3); 3.1492 (1.5); 3.1340 (1.2); 3.1270 (0.7); 3.0232 (1.1); 3.0038 (1.1); 2.9900 (2.7); 2.9705 (2.8); 2.9502 (2.6); 2.9322 (2.7); 2.9170 (1.1); 2.8989 (1.1); 2.5231 (0.5); 2.5096 (11.2); 2.5052 (23.7); 2.5006 (31.7); 2.4961 (22.6); 2.4916 (10.5); 2.4626 (3.6); 2.4496 (4.0); 2.4402 (3.7); 2.4306 (3.6); 2.4081 (0.6); 1.8737 (0.6); 1.8561 (1.2); 1.8389 (1.6); 1.8218 (1.2); 1.8042 (0.7); 0.8246 (14.1); 0.8122 (16.0); 0.8080 (15.4); 0.7956 (13.8); -0.0002 (4.2) I.2-16: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.5398 (0.9); 7.4562 (0.9); 7.4532 (1.7); 7.4496 (0.8); 7.4381 (1.3); 7.4358 (2.2); 7.4322 (1.3); 7.3400 (0.9); 7.3361 (2.3); 7.3339 (1.4); 7.3266 (5.8); 7.3232 (4.7); 7.3187 (2.6); 7.3081 (0.9); 7.3056 (0.5); 7.3007 (1.2); 7.2898 (1.0); 4.3623 (2.1); 4.3566 (2.0); 4.3479 (2.1); 4.3423 (2.1); 3.5477 (1.0); 3.5256 (1.7); 3.5238 (1.8); 3.5017 (1.6); 3.4045 (1.4); 3.3896 (1.7); 3.3803 (1.4); 3.3657 (7.2); 3.2169 (0.5); 3.2131 (0.6); 3.1979 (0.6); 3.1949 (0.8); 3.1797 (0.6); 3.0248 (0.6); 3.0054 (0.6); 2.9915 (1.5); 2.9721 (1.5); 2.9518 (1.4); 2.9338 (1.4); 2.9186 (0.6); 2.9005 (0.6); 2.5190 (0.8); 2.5101 (7.9); 2.5055 (17.6); 2.5009 (24.7); 2.4963 (17.4); 2.4917 (7.6); 2.4782 (1.9); 2.4588 (2.3); 2.4557 (2.2); 2.4406 (1.9); 1.8576 (0.6); 1.8406 (0.8); 1.8235 (0.6); 0.8252 (8.4); 0.8088 (16.0); 0.7924 (8.2); -0.0002 (6.1) I.2-17: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.5855 (0.8); 8.5712 (1.5); 8.5569 (0.8); 7.6134 (4.8); 7.6081 (4.9); 7.4380 (2.2); 7.4327 (2.0); 7.4172 (3.5); 7.4119 (3.4); 7.3515 (4.3); 7.3306 (2.6); 4.3318 (2.7); 4.3272 (2.7); 4.3175 (2.7); 4.3129 (2.7); 3.9308 (0.6); 3.5405 (1.5); 3.5183 (2.4); 3.5165 (2.6); 3.4944 (2.2); 3.3917 (2.0); 3.3769 (2.2); 3.3675 (1.4); 3.3528 (1.7); 3.2104 (0.5); 3.2070 (0.7); 3.2029 (0.8); 3.1923 (0.7); 3.1874 (0.9); 3.1851 (1.1); 3.1806 (0.6); 3.1698 (0.8); 3.1656 (0.5); 3.1623 (0.5); 3.0208 (0.8); 3.0014 (0.9); 2.9876 (2.1); 2.9681 (2.2); 2.9479 (2.0); 2.9298 (2.1); 2.9147 (0.8); 2.8965 (0.8); 2.5198 (0.6); 2.5112 (8.4); 2.5066 (18.5); 2.5020 (25.9); 2.4974 (18.0); 2.4928 (8.4); 2.4748 (2.5); 2.4505 (3.9); 2.4313 (2.5); 2.4080 (0.7); 2.3898 (0.6); 1.8512 (0.9); 1.8341 (1.2); 1.8170 (0.9); 0.8223 (11.9); 0.8041 (16.0); 0.7871 (11.6); -0.0002 (6.3) I.2-21: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.6901 (1.2); 8.6752 (2.2); 7.6547 (6.9); 7.6518 (7.8); 7.6467 (2.6); 7.6351 (4.3); 7.6326 (8.6); 7.6300 (6.8); 7.6243 (0.6); 7.5139 (1.5); 7.5101 (4.4); 7.5071 (3.8); 7.4908 (4.3); 7.4879 (6.5); 7.4841 (1.6); 7.4577 (0.6); 7.4439 (0.9); 7.4364 (1.0); 7.4230 (1.4); 7.4028 (16.0); 7.3932 (6.2); 7.3879 (2.0); 7.3835 (4.3); 7.3748 (7.7); 7.3718 (5.4); 7.3577 (2.2); 7.3530 (6.1); 7.1582 (1.7); 7.1554 (3.3); 7.1527 (1.8); 7.1371 (4.8); 7.1213 (1.3); 7.1185 (2.1); 7.1157 (1.0); 5.7549 (1.1); 4.3761 (7.1); 4.3618 (6.9); 4.0686 (2.6); 4.0471 (3.7); 4.0442 (4.3); 4.0228 (3.6); 3.9297 (3.5); 3.9149 (3.6); 3.9054 (2.6); 3.8906 (2.7); 3.8090 (1.3); 3.3719 (3.4); 3.3211 (379.4); 3.2709 (4.2); 3.2207 (0.8); 2.8176 (2.5); 2.7942 (2.4); 2.7753 (4.7); 2.7520 (4.1); 2.6957 (4.4); 2.6782 (5.0); 2.6748 (2.8); 2.6700 (3.4); 2.6655 (2.2); 2.6536 (2.3); 2.6359 (2.2); 2.5509 (1.9); 2.5463 (1.5); 2.5235 (9.6); 2.5189 (13.6); 2.5102 (177.2); 2.5056 (387.1); 2.5010 (542.7); 2.4963 (376.1); 2.4917 (164.1); 2.4601 (2.5); 2.4555 (4.2); 2.4509 (5.4); 2.4462 (4.0); 2.4417 (2.3); 2.3324 (2.6); 2.3277 (3.4); 2.3230 (2.6); 2.0731 (1.6); 1.4820 (1.2); 0.9264 (1.2); -0.0002 (11.5) I.2-22: 1 H-NMR (400.0 MHz, CDCl 3 ): δ= 7.5203 (6.5); 7.4249 (5.5); 7.4043 (6.1); 7.3636 (4.9); 7.3575 (4.4); 7.3204 (2.0); 7.3107 (6.9); 7.3080 (7.3); 7.2949 (4.9); 7.2878 (4.5); 7.2615 (903.3); 7.2589 (209.3); 7.2517 (6.1); 7.2476 (3.2); 7.2468 (3.2); 7.2397 (2.0); 7.2365 (1.9); 7.2341 (1.3); 7.2112 (10.3); 7.1985 (1.0); 7.1621 (2.2); 7.1291 (2.2); 7.1238 (2.3); 7.1085 (1.8); 7.1034 (1.9); 6.9974 (5.0); 5.8413 (1.0); 4.4815 (0.8); 4.4663 (0.8); 4.4435 (2.4); 4.4284 (2.4); 4.4117 (2.4); 4.3971 (2.2); 4.3749 (0.8); 4.3597 (0.7); 3.7088 (1.8); 3.6916 (1.9); 3.6842 (2.2); 3.6673 (2.3); 3.5374 (2.2); 3.5157 (2.7); 3.5129 (2.6); 3.4914 (2.0); 3.1684 (0.9); 3.1494 (1.2); 3.1352 (2.1); 3.1152 (2.2); 3.0862 (2.6); 3.0676 (2.4); 3.0344 (1.3); 3.0201 (0.6); 2.7594 (0.9); 2.7388 (0.8); 2.7168 (2.5); 2.6967 (2.3); 2.6775 (2.4); 2.6534 (2.2); 2.6355 (0.8); 2.6119 (0.7); 2.0090 (0.9); 1.9492 (1.1); 1.9310 (1.7); 1.9131 (2.0); 1.8960 (1.7); 1.8790 (1.4); 1.6751 (1.4); 1.6184 (1.6); 1.6069 (4.4); 1.5604 (274.2); 1.5101 (4.0); 0.9150 (13.8); 0.9117 (16.0); 0.8983 (13.5); 0.8950 (15.2); 0.1464 (1.3); 0.0753 (0.6); 0.0466 (2.1); 0.0079 (10.7); -0.0002 (249.5); -0.0029 (57.5); -0.0085 (8.1); -0.0505 (2.6); -0.1496 (0.8) I.2-26: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.5315 (4.1); 8.5239 (4.3); 8.5115 (4.4); 8.5032 (4.1); 8.2049 (11.4); 7.8558 (5.2); 7.8354 (6.2); 7.6521 (3.2); 7.6486 (3.2); 7.6319 (6.2); 7.6281 (6.3); 7.6124 (3.4); 7.5058 (7.9); 7.4865 (6.0); 7.4215 (0.7); 7.2692 (4.4); 7.2503 (13.0); 7.2341 (9.9); 7.2248 (15.6); 7.2223 (16.0); 7.2174 (14.2); 7.2119 (11.2); 7.2048 (6.2); 7.1998 (6.7); 7.1952 (6.0); 7.1818 (3.7); 7.1645 (1.2); 5.3366 (2.6); 5.3173 (7.5); 5.2976 (7.6); 5.2777 (2.5); 4.4095 (0.6); 4.1318 (3.0); 4.1077 (5.9); 4.1022 (3.4); 4.0861 (5.0); 4.0805 (5.1); 4.0779 (5.8); 4.0564 (4.6); 4.0299 (4.8); 4.0149 (5.1); 4.0055 (4.0); 4.0018 (5.4); 3.9905 (4.2); 3.9869 (5.5); 3.9774 (3.2); 3.9625 (3.2); 3.3290 (47.4); 3.2960 (13.3); 3.2788 (7.9); 3.2568 (3.7); 2.9805 (2.0); 2.9725 (2.3); 2.9584 (2.4); 2.9501 (2.5); 2.9411 (3.9); 2.9326 (4.2); 2.9189 (4.2); 2.9105 (3.9); 2.8628 (2.8); 2.8556 (3.2); 2.8349 (6.8); 2.8202 (8.2); 2.8147 (5.9); 2.8075 (3.0); 2.7972 (9.8); 2.7870 (12.5); 2.7681 (8.1); 2.7650 (7.7); 2.7553 (7.5); 2.7438 (3.0); 2.7372 (6.8); 2.7257 (2.3); 2.7128 (2.3); 2.6947 (2.1); 2.6740 (2.8); 2.6695 (3.8); 2.6649 (2.7); 2.6602 (1.3); 2.5943 (0.6); 2.5499 (2.0); 2.5316 (2.7); 2.5229 (11.4); 2.5182 (16.0); 2.5095 (203.3); 2.5050 (439.3); 2.5004 (611.4); 2.4958 (431.3); 2.4912 (195.0); 2.4757 (1.8); 2.4710 (1.1); 2.4563 (1.0); 2.4479 (1.6); 2.4366 (2.7); 2.4292 (3.5); 2.4212 (2.8); 2.4171 (3.5); 2.4092 (3.3); 2.4053 (3.1); 2.3981 (3.9); 2.3897 (2.5); 2.3783 (1.9); 2.3700 (1.2); 2.3365 (1.2); 2.3317 (2.6); 2.3272 (3.6); 2.3225 (2.5); 2.0721 (1.1); 1.8555 (1.3); 1.8493 (1.3); 1.8340 (3.0); 1.8275 (3.2); 1.8142 (3.2); 1.8075 (3.4); 1.7960 (3.1); 1.7828 (3.0); 1.7760 (2.9); 1.7611 (1.2); 1.7540 (1.4); 1.2457 (0.7); 0.9327 (0.9); 0.9145 (1.9); 0.8958 (1.0); 0.8583 (1.1); 0.0080 (4.0); -0.0002 (137.7); -0.0086 (4.0) I.2-31: 1 H-NMR (400.0 MHz, CDCl 3 ): δ= 8.3132 (7.0); 8.3004 (7.1); 8.1306 (16.0); 7.6652 (6.9); 7.5197 (0.8); 7.2713 (0.9); 7.2697 (1.1); 7.2690 (1.2); 7.2607 (149.2); 7.1730 (0.8); 7.1487 (4.3); 7.1454 (4.5); 7.1359 (4.2); 7.1326 (4.3); 6.9967 (0.8); 6.9093 (8.2); 6.9078 (8.1); 6.8382 (0.8); 6.1246 (1.9); 5.2987 (4.2); 4.5985 (0.5); 4.5833 (0.6); 4.5589 (5.9); 4.5515 (6.0); 4.5437 (5.9); 4.5362 (5.9); 4.5119 (0.6); 4.4965 (0.6); 4.2887 (4.1); 4.2710 (4.4); 4.2649 (5.2); 4.2472 (5.2); 4.0882 (4.8); 4.0668 (6.0); 4.0645 (5.1); 4.0430 (4.0); 3.3264 (0.9); 3.3053 (2.2); 3.2877 (2.3); 3.2847 (2.8); 3.2816 (2.7); 3.2640 (2.5); 3.2608 (1.6); 3.2429 (1.1); 3.0354 (2.8); 3.0146 (2.3); 2.9925 (7.5); 2.9837 (0.9); 2.9717 (6.9); 2.9629 (0.9); 2.9537 (7.6); 2.9299 (6.7); 2.9108 (2.7); 2.8870 (2.3); 1.5612 (5.6); 1.3227 (1.1); 1.2746 (1.5); 1.2561 (0.8); 0.0080 (1.6); -0.0002 (55.6); - 0.0085 (1.6) I.2-34: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.4829 (2.2); 7.7137 (3.4); 7.7074 (4.6); 7.7011 (4.6); 7.6952 (5.8); 7.6902 (5.7); 7.6843 (5.4); 7.6778 (5.2); 7.6719 (4.6); 7.2432 (6.3); 7.2378 (7.7); 7.2314 (5.1); 7.2157 (16.0); 7.1986 (7.4); 7.1938 (6.4); 5.3158 (3.9); 5.2949 (3.4); 4.0287 (2.6); 4.0067 (2.4); 3.9981 (3.0); 3.9763 (2.8); 3.9553 (2.2); 3.9401 (2.4); 3.9304 (3.5); 3.9158 (3.8); 3.3156 (95.1); 3.2682 (3.3); 3.2491 (2.6); 2.9287 (2.2); 2.9160 (2.2); 2.9064 (2.0); 2.8330 (3.4); 2.8113 (2.4); 2.7927 (2.4); 2.7638 (4.1); 2.7406 (5.1); 2.7289 (3.4); 2.7205 (3.9); 2.7130 (3.4); 2.7067 (3.3); 2.6940 (3.4); 2.6697 (3.1); 2.5227 (9.0); 2.5093 (174.6); 2.5048 (377.9); 2.5002 (523.1); 2.4956 (367.1); 2.4910 (163.6); 2.4258 (2.3); 2.3271 (2.8); 1.8242 (2.2); 1.7921 (2.1); 0.0079 (3.2); -0.0002 (99.6); -0.0087 (2.6) I.2-35: 1 H-NMR (400.0 MHz, CDCl3): δ= 7.4142 (0.7); 7.3996 (0.7); 7.3932 (0.5); 7.3784 (0.5); 7.2749 (1.8); 7.2719 (2.3); 7.2593 (88.1); 7.2423 (1.8); 7.2317 (0.9); 7.2200 (0.6); 6.9406 (0.5); 6.9353 (0.6); 6.9290 (0.8); 6.9232 (0.9); 6.9212 (1.0); 6.9141 (0.6); 6.9084 (1.3); 6.9020 (0.9); 6.8874 (0.6); 5.5358 (0.7); 5.5165 (0.7); 4.1157 (0.6); 4.0976 (0.6); 4.0918 (0.8); 4.0740 (0.8); 3.9712 (0.9); 3.9495 (1.1); 3.9260 (0.7); 3.2268 (0.6); 2.9800 (0.9); 2.9593 (0.7); 2.9375 (1.3); 2.9292 (0.8); 2.9169 (1.1); 2.9093 (0.6); 2.7970 (1.2); 2.7735 (1.1); 2.7545 (0.8); 2.7310 (0.7); 1.5383 (16.0); 0.0080 (1.0); -0.0002 (32.1); -0.0085 (1.0) I.2-36: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.6951 (0.6); 8.3351 (1.2); 8.3303 (1.2); 7.7654 (0.8); 7.7591 (0.8); 7.7449 (1.0); 7.7386 (0.9); 7.5429 (2.9); 7.5371 (0.8); 7.5256 (0.9); 7.5198 (3.2); 7.5002 (1.6); 7.4797 (1.3); 7.4781 (1.3); 6.9434 (3.2); 6.9376 (0.8); 6.9262 (0.8); 6.9204 (2.8); 5.7553 (0.6); 4.3371 (1.9); 4.3225 (1.9); 3.9873 (0.6); 3.9633 (1.0); 3.9415 (0.8); 3.8657 (0.9); 3.8501 (0.9); 3.8414 (0.6); 3.8257 (0.7); 3.7390 (16.0); 3.7197 (0.6); 3.3184 (142.9); 3.2776 (0.6); 3.2684 (1.1); 2.7434 (0.5); 2.7012 (1.1); 2.6780 (1.2); 2.6747 (0.8); 2.6700 (0.8); 2.6652 (0.6); 2.6563 (1.2); 2.6378 (1.1); 2.5234 (2.1); 2.5187 (3.1); 2.5100 (44.5); 2.5055 (97.6); 2.5008 (137.3); 2.4962 (96.0); 2.4916 (42.5); 2.4603 (0.7); 2.4557 (1.1); 2.4510 (1.3); 2.4464 (0.9); 2.4420 (0.6); 2.3323 (0.6); 2.3277 (0.9); 2.3230 (0.6); 2.0733 (0.6); 0.0080 (0.6); -0.0002 (19.7); -0.0085 (0.6) I.2-37: 1 H-NMR (400.0 MHz, CDCl 3 ): δ= 7.3917 (1.9); 7.3831 (1.5); 7.3771 (1.9); 7.3685 (2.6); 7.3008 (0.6); 7.2965 (0.8); 7.2820 (0.9); 7.2801 (0.9); 7.2777 (1.2); 7.2759 (1.1); 7.2705 (0.6); 7.2604 (23.7); 7.2572 (2.9); 7.2514 (2.3); 7.2456 (2.0); 7.2417 (1.8); 7.2368 (3.5); 7.0017 (0.8); 6.9986 (1.0); 6.9827 (1.3); 6.9796 (1.4); 6.9636 (0.7); 6.9604 (0.8); 6.9501 (1.4); 6.9473 (1.2); 6.9294 (1.2); 6.9266 (1.0); 4.5805 (3.4); 4.5658 (3.3); 4.0044 (0.9); 3.9882 (1.0); 3.9798 (1.3); 3.9636 (1.4); 3.8920 (1.4); 3.8712 (1.5); 3.8673 (1.0); 3.8465 (1.0); 3.7551 (16.0); 3.2475 (0.7); 2.9062 (0.8); 2.8875 (0.7); 2.8638 (1.6); 2.8451 (1.4); 2.7970 (1.4); 2.7734 (1.3); 2.7546 (0.7); 2.7310 (0.6); -0.0002 (7.2) I.2-38: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.5225 (3.6); 8.5149 (3.5); 8.5021 (3.6); 7.6485 (10.4); 7.6431 (10.3); 7.6376 (4.0); 7.5019 (2.7); 7.4965 (3.6); 7.4836 (4.6); 7.4811 (4.7); 7.4785 (5.3); 7.4758 (7.1); 7.4494 (5.9); 7.4439 (5.8); 7.4286 (12.0); 7.4244 (9.6); 7.4088 (3.7); 7.4031 (3.4); 7.2675 (3.7); 7.2428 (16.0); 7.2403 (15.4); 7.2207 (15.7); 7.2154 (11.6); 7.2103 (10.3); 7.2042 (8.4); 7.1820 (2.9); 7.1636 (1.2); 7.0576 (5.8); 7.0551 (5.3); 6.9692 (5.1); 6.9493 (4.9); 5.3329 (1.9); 5.3136 (5.7); 5.2933 (5.7); 5.2736 (1.9); 4.0763 (2.4); 4.0520 (4.6); 4.0466 (2.8); 4.0302 (4.0); 4.0227 (4.5); 4.0011 (3.4); 3.9717 (3.7); 3.9567 (4.0); 3.9448 (4.2); 3.9299 (4.3); 3.9201 (2.4); 3.9053 (2.4); 3.3645 (3.4); 3.3135 (510.2); 3.2739 (6.9); 3.2577 (4.1); 3.2361 (1.6); 2.9796 (1.7); 2.9712 (2.0); 2.9571 (2.0); 2.9489 (2.2); 2.9396 (3.3); 2.9311 (3.5); 2.9172 (3.4); 2.9092 (3.3); 2.8542 (2.6); 2.8335 (5.4); 2.8130 (4.4); 2.8062 (2.5); 2.7972 (7.1); 2.7832 (2.4); 2.7743 (6.4); 2.7633 (10.5); 2.7447 (5.9); 2.7410 (6.0); 2.7328 (5.8); 2.7205 (2.4); 2.7145 (5.5); 2.7022 (1.9); 2.6900 (2.0); 2.6738 (5.6); 2.6694 (7.3); 2.6647 (5.1); 2.5553 (3.2); 2.5506 (3.6); 2.5460 (2.8); 2.5341 (5.0); 2.5228 (21.3); 2.5180 (31.5); 2.5093 (390.1); 2.5048 (831.9); 2.5002 (1151.0); 2.4956 (811.4); 2.4911 (366.7); 2.4688 (1.5); 2.4638 (1.2); 2.4510 (2.8); 2.4459 (2.6); 2.4345 (1.8); 2.4266 (2.3); 2.4145 (2.4); 2.4026 (3.1); 2.3960 (3.3); 2.3879 (2.3); 2.3316 (4.9); 2.3270 (6.8); 2.3224 (4.9); 2.0717 (1.5); 1.8445 (1.0); 1.8287 (2.6); 1.8231 (2.6); 1.8089 (2.4); 1.8032 (2.9); 1.7976 (2.6); 1.7915 (2.3); 1.7775 (2.5); 1.7717 (2.4); 1.7559 (1.1); 1.7501 (1.1); 0.9216 (0.7); 0.8583 (0.6); 0.0080 (1.5); -0.0002 (52.2); -0.0086 (1.3) I.2-39: 1 H-NMR (400.0 MHz, CDCl 3 ): δ= 7.4202 (0.5); 7.4118 (0.9); 7.3972 (0.9); 7.3909 (0.7); 7.3761 (0.6); 7.2933 (0.7); 7.2770 (2.9); 7.2731 (2.2); 7.2682 (5.2); 7.2594 (85.0); 7.2476 (0.8); 6.9401 (0.6); 6.9373 (0.7); 6.9312 (0.7); 6.9251 (1.2); 6.9200 (1.1); 6.9180 (1.2); 6.9101 (0.7); 6.9043 (1.5); 6.9000 (0.9); 6.8985 (0.9); 6.8832 (0.7); 5.5354 (0.9); 5.5163 (0.8); 4.1043 (0.7); 4.0864 (0.8); 4.0804 (1.0); 4.0626 (1.0); 3.9497 (1.1); 3.9278 (1.4); 3.9045 (0.9); 3.2430 (0.6); 3.2250 (0.6); 3.2223 (0.8); 3.2196 (0.7); 3.2016 (0.6); 3.0060 (0.6); 2.9956 (1.7); 2.9840 (0.6); 2.9749 (1.3); 2.9532 (1.7); 2.9420 (0.5); 2.9326 (1.6); 2.9223 (1.0); 2.9022 (0.7); 2.8213 (1.6); 2.7976 (1.5); 2.7788 (1.1); 2.7552 (0.9); 2.6534 (0.5); 2.6427 (0.6); 2.6209 (0.6); 2.6103 (0.5); 1.8480 (0.5); 1.5409 (16.0); 0.0080 (1.0); -0.0002 (32.4); -0.0085 (0.9) I.2-40: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.5157 (3.5); 8.5035 (3.4); 8.4954 (3.2); 7.9893 (8.8); 7.7752 (4.5); 7.7575 (5.2); 7.5542 (2.9); 7.5337 (5.6); 7.5112 (2.9); 7.3773 (1.5); 7.3516 (6.0); 7.3310 (4.9); 7.2693 (3.8); 7.2508 (8.6); 7.2343 (7.1); 7.2236 (16.0); 7.2115 (11.6); 7.2027 (8.3); 7.1993 (8.2); 7.1807 (7.1); 7.0456 (7.8); 7.0418 (7.5); 6.9061 (3.6); 6.9022 (3.6); 5.3368 (2.1); 5.3173 (5.9); 5.2975 (5.8); 5.2779 (1.8); 4.3426 (0.8); 4.3241 (1.4); 4.1056 (2.3); 4.0815 (4.8); 4.0757 (2.7); 4.0599 (4.1); 4.0518 (4.5); 4.0303 (3.7); 3.9989 (4.0); 3.9842 (4.0); 3.9724 (4.6); 3.9574 (4.4); 3.9481 (2.4); 3.9330 (2.5); 3.3159 (380.2); 3.2513 (3.2); 2.9802 (1.7); 2.9715 (1.8); 2.9589 (1.8); 2.9487 (2.0); 2.9399 (3.5); 2.9313 (3.7); 2.9184 (4.0); 2.9097 (3.7); 2.8907 (1.2); 2.8693 (1.2); 2.8547 (2.4); 2.8466 (2.2); 2.8336 (5.1); 2.8235 (1.9); 2.8132 (5.7); 2.8040 (5.9); 2.7945 (3.5); 2.7811 (5.8); 2.7733 (8.5); 2.7555 (5.6); 2.7481 (6.1); 2.7437 (6.8); 2.7309 (2.2); 2.7253 (5.6); 2.7128 (1.6); 2.7012 (1.8); 2.6783 (2.9); 2.6739 (6.0); 2.6693 (8.7); 2.6647 (6.1); 2.5539 (6.0); 2.5494 (11.1); 2.5449 (10.2); 2.5402 (7.2); 2.5227 (26.3); 2.5180 (36.9); 2.5093 (483.2); 2.5048 (1053.6); 2.5002 (1473.3); 2.4956 (1048.9); 2.4910 (480.8); 2.4571 (1.3); 2.4361 (2.3); 2.4279 (3.1); 2.4167 (3.1); 2.4048 (3.0); 2.3975 (3.4); 2.3899 (2.6); 2.3697 (1.9); 2.3316 (7.0); 2.3270 (9.1); 2.3224 (6.7); 2.3178 (3.1); 2.0719 (1.8); 1.8501 (1.3); 1.8297 (3.5); 1.8197 (1.4); 1.8080 (3.5); 1.7985 (3.4); 1.7764 (3.1); 1.7546 (1.3); 1.7053 (0.8); 1.6836 (1.0); 1.2478 (3.4); 0.9110 (1.6); 0.8907 (0.9); 0.8747 (1.7); 0.8584 (6.1); 0.8407 (2.4); 0.0080 (1.9); -0.0002 (64.3); -0.0086 (2.0) I.2-41: 1 H-NMR (400.0 MHz, CDCl3): δ= 8.7289 (7.2); 7.9794 (7.8); 7.9747 (7.8); 7.5284 (4.8); 7.5230 (9.4); 7.5186 (5.9); 7.4529 (3.3); 7.4505 (3.8); 7.4477 (3.0); 7.4452 (3.0); 7.4321 (5.5); 7.4298 (5.6); 7.4270 (5.5); 7.4246 (4.8); 7.3768 (7.7); 7.3563 (12.2); 7.3357 (5.2); 7.3108 (0.6); 7.2601 (369.0); 7.2104 (0.7); 7.1773 (2.6); 6.9962 (2.1); 6.9415 (3.6); 6.9376 (3.6); 6.9214 (3.3); 6.9174 (3.2); 6.7141 (7.8); 6.5296 (16.0); 6.3450 (8.1); 4.7741 (10.1); 4.7632 (10.0); 4.2299 (5.5); 4.2113 (5.6); 4.2057 (6.7); 4.1872 (7.0); 4.0528 (6.3); 4.0313 (7.7); 4.0288 (6.0); 4.0072 (5.2); 3.4180 (1.2); 3.3965 (3.0); 3.3756 (3.5); 3.3546 (3.1); 3.3331 (1.3); 3.0692 (5.1); 3.0477 (4.3); 3.0266 (8.4); 3.0050 (7.9); 2.9357 (8.5); 2.9121 (7.8); 2.8930 (4.7); 2.8693 (4.2); 2.1350 (0.5); 1.6131 (3.4); 1.3655 (0.8); 0.0694 (0.7); 0.0080 (4.0); -0.0002 (133.3); -0.0086 (3.8); -0.1494 (0.5) I.2-42: 1 H-NMR (400.0 MHz, CDCl 3 ): δ= 8.7265 (9.9); 7.9820 (10.5); 7.9774 (10.9); 7.9060 (4.9); 7.8852 (5.8); 7.8496 (10.0); 7.5186 (8.5); 7.5004 (8.5); 7.4801 (5.6); 7.4299 (7.6); 7.4105 (4.6); 7.3094 (2.3); 7.2945 (0.6); 7.2906 (1.3); 7.2875 (1.8); 7.2597 (961.1); 7.2267 (1.0); 7.2201 (0.9); 7.1987 (2.2); 7.1836 (3.8); 7.1600 (1.3); 6.9957 (5.5); 4.7781 (14.4); 4.7672 (14.2); 4.2752 (7.5); 4.2570 (8.1); 4.2512 (10.0); 4.2330 (9.9); 4.0919 (9.3); 4.0705 (11.2); 4.0680 (8.9); 4.0465 (7.6); 3.4381 (1.6); 3.4167 (4.3); 3.3959 (5.0); 3.3934 (4.8); 3.3751 (4.4); 3.3537 (1.9); 3.0851 (7.0); 3.0638 (5.8); 3.0423 (12.3); 3.0210 (11.4); 2.9567 (12.4); 2.9331 (11.5); 2.9140 (6.5); 2.8903 (6.0); 2.1352 (0.6); 2.0049 (1.1); 1.5577 (16.0); 1.4330 (1.5); 1.4147 (2.6); 1.3966 (1.3); 0.1460 (1.2); 0.0691 (0.8); 0.0496 (0.7); 0.0079 (10.5); -0.0002 (354.1); -0.0085 (10.4); -0.1496 (1.3) I.2-43: 1 H-NMR (400.0 MHz, CDCl 3 ): δ= 7.6507 (2.5); 7.6306 (5.3); 7.6099 (3.1); 7.4101 (3.5); 7.3911 (6.8); 7.3719 (3.5); 7.2595 (15.1); 7.1975 (5.1); 7.1788 (6.8); 7.1605 (5.3); 7.1292 (1.9); 7.0741 (1.2); 7.0542 (0.8); 6.9731 (0.7); 6.9559 (0.8); 6.9404 (0.6); 5.9440 (0.5); 4.9827 (0.7); 4.6648 (1.0); 4.6387 (1.1); 4.6001 (0.6); 4.5834 (0.9); 4.5692 (1.0); 4.5573 (0.8); 4.5440 (0.8); 3.7431 (0.8); 3.7175 (1.4); 3.6883 (1.6); 3.6618 (1.1); 3.2461 (0.8); 3.2119 (1.5); 3.1861 (1.0); 3.1708 (1.2); 3.1445 (0.8); 2.8481 (1.9); 2.7953 (1.9); 2.7712 (5.4); 2.7555 (4.9); 2.7316 (1.3); 2.7140 (1.5); 2.6965 (3.6); 2.6585 (7.5); 2.1085 (1.2); 2.0838 (1.6); 2.0378 (1.4); 2.0170 (1.5); 2.0008 (1.6); 1.9585 (0.7); 1.8846 (0.6); 1.8592 (1.1); 1.8451 (1.1); 1.8313 (1.1); 1.8152 (1.1); 1.7879 (0.8); 1.7499 (0.5); 1.6540 (4.6); 1.6074 (16.0); 1.5919 (2.6); -0.0002 (16.8); -0.0085 (0.5) I.2-46: 1 H-NMR (400.0 MHz, CDCl3): δ= 7.5204 (3.5); 7.3764 (1.6); 7.3237 (4.0); 7.3116 (5.6); 7.2616 (452.1); 7.2084 (1.4); 7.1618 (0.9); 7.1485 (1.8); 7.1434 (1.8); 7.1298 (4.4); 7.1085 (3.9); 7.0871 (1.2); 6.9975 (2.6); 5.8317 (1.0); 4.4717 (0.8); 4.4569 (0.8); 4.4347 (2.5); 4.4198 (2.5); 4.4072 (2.4); 4.3925 (2.4); 4.3704 (0.7); 4.3542 (0.7); 3.7090 (1.8); 3.6923 (1.9); 3.6847 (2.2); 3.6675 (2.3); 3.5350 (2.3); 3.5121 (2.8); 3.4890 (1.8); 3.1677 (1.1); 3.1482 (1.2); 3.1343 (2.4); 3.1142 (2.5); 3.0967 (0.7); 3.0855 (2.5); 3.0674 (2.5); 3.0524 (2.3); 3.0341 (2.0); 3.0145 (0.6); 2.7574 (1.1); 2.7368 (1.0); 2.7151 (2.7); 2.6948 (2.5); 2.6732 (2.8); 2.6492 (2.4); 2.6315 (1.0); 2.6074 (0.9); 1.9651 (0.7); 1.9475 (1.1); 1.9303 (1.7); 1.9131 (1.9); 1.8959 (1.7); 1.8787 (1.2); 1.6118 (2.5); 1.5610 (189.7); 1.5084 (0.9); 0.9148 (13.8); 0.9114 (16.0); 0.8982 (13.3); 0.8948 (15.2); 0.1458 (1.0); 0.0495 (1.2); 0.0078 (6.2); -0.0002 (133.1); -0.0083 (5.0); -0.1497 (0.7) I.2-48: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.6804 (1.2); 8.6657 (2.4); 8.6510 (1.2); 7.6570 (6.6); 7.6542 (8.1); 7.6490 (2.1); 7.6399 (2.4); 7.6374 (4.4); 7.6350 (9.2); 7.6324 (7.8); 7.6266 (0.9); 7.4068 (1.0); 7.4006 (9.5); 7.3955 (4.1); 7.3908 (6.9); 7.3846 (4.9); 7.3792 (16.0); 7.3725 (9.4); 7.3694 (6.4); 7.3641 (1.0); 7.3554 (2.2); 7.3507 (6.7); 7.3452 (0.8); 7.3128 (1.6); 7.3068 (11.4); 7.3014 (3.2); 7.2904 (2.6); 7.2851 (7.2); 7.2790 (0.8); 7.1571 (1.7); 7.1543 (3.4); 7.1515 (1.9); 7.1359 (5.4); 7.1202 (1.4); 7.1174 (2.5); 7.1146 (1.3); 4.3072 (7.8); 4.2924 (7.7); 4.0428 (2.7); 4.0213 (3.9); 4.0186 (4.6); 3.9971 (3.9); 3.9145 (3.9); 3.8991 (4.1); 3.8902 (2.8); 3.8749 (2.9); 3.3373 (0.9); 3.3195 (142.6); 3.3037 (1.4); 3.2980 (2.1); 3.2810 (1.4); 3.2776 (1.1); 3.2747 (1.0); 3.2696 (1.2); 3.2594 (0.8); 2.7896 (2.4); 2.7664 (2.3); 2.7473 (5.5); 2.7241 (5.0); 2.6947 (5.4); 2.6764 (5.2); 2.6699 (0.9); 2.6653 (0.6); 2.6525 (2.3); 2.6341 (2.2); 2.5234 (1.5); 2.5188 (2.2); 2.5100 (33.9); 2.5054 (74.9); 2.5008 (104.6); 2.4962 (72.9); 2.4916 (32.0); 2.4555 (0.6); 2.4510 (0.9); 2.4463 (0.7); 2.3277 (0.7); 0.0081 (1.3); -0.0002 (48.6); -0.0086 (1.4) I.2-49: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.6500 (2.0); 8.6348 (3.7); 8.6205 (2.0); 7.6604 (11.0); 7.6575 (13.6); 7.6524 (3.7); 7.6432 (4.2); 7.6407 (7.7); 7.6383 (15.5); 7.6357 (13.2); 7.6300 (1.7); 7.3960 (1.6); 7.3910 (10.8); 7.3858 (3.4); 7.3780 (2.2); 7.3725 (13.8); 7.3696 (10.9); 7.3643 (2.0); 7.3553 (6.0); 7.3511 (14.1); 7.3455 (1.9); 7.3359 (9.0); 7.3335 (12.2); 7.3311 (9.0); 7.3207 (4.7); 7.3158 (13.7); 7.3141 (10.1); 7.2809 (15.4); 7.2801 (16.0); 7.2745 (3.6); 7.2696 (5.9); 7.2670 (7.2); 7.2647 (8.3); 7.2633 (9.7); 7.2545 (3.1); 7.2489 (6.3); 7.2427 (1.4); 7.2351 (1.4); 7.2313 (2.2); 7.2275 (1.1); 7.1566 (3.0); 7.1539 (5.7); 7.1511 (3.2); 7.1354 (9.0); 7.1197 (2.4); 7.1170 (4.2); 7.1142 (2.2); 4.3235 (13.7); 4.3088 (13.5); 4.0466 (4.6); 4.0251 (6.6); 4.0224 (7.9); 4.0010 (6.8); 3.9226 (6.8); 3.9072 (7.1); 3.8983 (4.9); 3.8830 (5.0); 3.7288 (1.0); 3.3436 (1.3); 3.3189 (235.3); 3.3099 (3.8); 3.3042 (4.0); 3.2875 (2.4); 3.2837 (1.9); 3.2686 (1.7); 3.2655 (1.4); 2.7910 (3.9); 2.7679 (3.6); 2.7488 (9.6); 2.7257 (8.8); 2.7013 (9.4); 2.6830 (8.9); 2.6744 (1.1); 2.6696 (1.4); 2.6650 (1.1); 2.6591 (3.9); 2.6407 (3.5); 2.5231 (2.7); 2.5184 (4.2); 2.5097 (64.8); 2.5051 (142.5); 2.5005 (198.5); 2.4959 (138.8); 2.4913 (61.9); 2.4591 (0.7); 2.4549 (1.1); 2.4502 (1.5); 2.4456 (1.3); 2.3320 (0.9); 2.3273 (1.3); 2.3227 (0.9); 2.0731 (0.5); 0.0080 (2.5); 0.0063 (0.9); -0.0002 (85.7); -0.0060 (1.0); -0.0068 (1.0); -0.0085 (2.6) I.2-50: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.6437 (0.6); 7.5448 (2.9); 7.5391 (0.9); 7.5277 (0.8); 7.5218 (3.2); 7.3993 (2.3); 7.3942 (0.8); 7.3831 (1.0); 7.3779 (3.7); 7.3030 (2.7); 7.2977 (0.8); 7.2814 (1.8); 6.9447 (3.1); 6.9389 (0.9); 6.9274 (0.8); 6.9217 (2.9); 4.3038 (1.8); 4.2890 (1.8); 3.9913 (0.6); 3.9695 (0.9); 3.9672 (1.1); 3.9455 (0.8); 3.8699 (0.8); 3.8543 (0.9); 3.8457 (0.6); 3.8302 (0.7); 3.7400 (16.0); 3.3119 (17.0); 2.7039 (1.2); 2.6806 (1.1); 2.6610 (1.3); 2.6424 (1.1); 2.5229 (0.7); 2.5182 (1.0); 2.5095 (12.3); 2.5050 (26.7); 2.5003 (37.2); 2.4957 (25.9); 2.4911 (11.5); -0.0002 (5.0) I.2-56: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.6925 (2.2); 8.6775 (4.2); 8.6639 (2.1); 7.6562 (10.8); 7.6533 (12.9); 7.6482 (3.5); 7.6366 (7.7); 7.6342 (14.6); 7.6315 (12.3); 7.6238 (12.7); 7.6187 (12.8); 7.4455 (5.3); 7.4403 (4.6); 7.4247 (10.8); 7.4194 (10.6); 7.3924 (14.1); 7.3903 (16.0); 7.3741 (13.7); 7.3708 (12.6); 7.3573 (3.8); 7.3525 (10.2); 7.1585 (2.9); 7.1557 (5.3); 7.1530 (2.9); 7.1373 (8.4); 7.1216 (2.2); 7.1188 (3.8); 7.1161 (1.9); 4.3612 (12.7); 4.3468 (12.4); 4.0558 (4.2); 4.0343 (6.0); 4.0316 (6.8); 4.0101 (6.0); 3.9225 (6.0); 3.9072 (6.3); 3.8981 (4.3); 3.8829 (4.6); 3.5625 (0.7); 3.5190 (1.0); 3.3778 (1.1); 3.3556 (2.2); 3.3392 (4.0); 3.3185 (567.2); 3.3007 (2.0); 3.2686 (4.7); 2.8035 (3.9); 2.7803 (3.6); 2.7613 (8.3); 2.7380 (7.4); 2.7019 (8.0); 2.6838 (7.6); 2.6746 (2.0); 2.6700 (2.6); 2.6653 (2.0); 2.6597 (4.1); 2.6415 (3.6); 2.5235 (6.3); 2.5188 (9.4); 2.5101 (134.3); 2.5055 (292.0); 2.5009 (405.2); 2.4963 (283.0); 2.4917 (125.6); 2.4601 (1.8); 2.4557 (3.0); 2.4508 (3.6); 2.4463 (2.4); 2.3323 (1.8); 2.3277 (2.4); 2.3231 (1.8); 2.0854 (7.5); 2.0735 (1.6); 1.2358 (1.8); 0.8905 (1.7); 0.8739 (1.8); 0.8523 (0.6); 0.8436 (0.8); 0.8245 (0.8); 0.1461 (0.5); 0.0079 (4.8); -0.0002 (173.4); -0.0068 (2.1); -0.0085 (5.4); -0.0502 (1.2) I.2-58: 1 H-NMR (400.0 MHz, CDCl 3 ): δ= 8.5551 (0.5); 8.5527 (0.6); 8.5509 (0.6); 8.5485 (0.6); 8.5428 (0.6); 8.5404 (0.6); 8.5386 (0.6); 8.5362 (0.5); 7.7139 (0.6); 7.7094 (0.6); 7.6947 (1.0); 7.6902 (1.0); 7.6755 (0.7); 7.6710 (0.7); 7.4853 (3.0); 7.4795 (0.9); 7.4681 (0.9); 7.4623 (3.3); 7.2762 (1.0); 7.2609 (28.2); 7.2568 (1.2); 7.2512 (0.6); 7.2387 (0.5); 7.2323 (0.5); 6.9123 (3.2); 6.9066 (0.9); 6.8951 (0.9); 6.8894 (2.9); 4.6119 (2.3); 4.6003 (2.2); 4.1822 (0.9); 4.1632 (0.9); 4.1581 (1.1); 4.1391 (1.1); 3.9757 (1.1); 3.9541 (1.3); 3.9516 (1.0); 3.9299 (0.9); 3.7980 (16.0); 3.3089 (0.6); 3.3068 (0.6); 3.2876 (0.5); 3.0161 (0.8); 2.9941 (0.7); 2.9738 (1.3); 2.9517 (1.2); 2.8613 (1.3); 2.8376 (1.2); 2.8189 (0.8); 2.7953 (0.7); -0.0002 (12.2) I.2-59: 1 H-NMR (400.0 MHz, CDCl3): δ= 8.5583 (3.7); 8.5559 (4.3); 8.5540 (4.5); 8.5516 (3.9); 8.5460 (3.9); 8.5436 (4.5); 8.5417 (4.4); 8.5393 (3.8); 7.7219 (4.0); 7.7174 (4.0); 7.7027 (7.1); 7.6982 (7.1); 7.6835 (4.8); 7.6791 (4.6); 7.6043 (10.8); 7.6014 (13.0); 7.5962 (3.6); 7.5872 (4.1); 7.5848 (7.6); 7.5823 (14.8); 7.5796 (13.2); 7.5739 (1.6); 7.5199 (1.2); 7.3954 (1.7); 7.3904 (10.6); 7.3888 (4.5); 7.3852 (3.5); 7.3772 (2.2); 7.3718 (13.2); 7.3693 (9.8); 7.3638 (1.7); 7.3550 (4.0); 7.3522 (4.1); 7.3503 (10.4); 7.3449 (1.4); 7.2835 (6.9); 7.2610 (218.3); 7.2560 (5.1); 7.2520 (1.2); 7.2512 (1.1); 7.2504 (1.0); 7.2464 (3.9); 7.2449 (3.6); 7.2434 (3.6); 7.2416 (3.0); 7.2399 (3.8); 7.2384 (3.3); 7.2370 (3.2); 7.2275 (3.5); 7.2261 (3.0); 7.2247 (2.9); 7.2112 (1.7); 7.1815 (3.1); 7.1787 (5.8); 7.1758 (3.3); 7.1637 (3.4); 7.1602 (9.0); 7.1583 (4.1); 7.1565 (3.0); 7.1444 (2.8); 7.1416 (4.8); 7.1388 (3.0); 7.1217 (2.1); 6.9970 (1.2); 4.6189 (16.0); 4.6072 (15.9); 4.2258 (6.5); 4.2066 (6.9); 4.2016 (8.1); 4.1824 (8.4); 4.0255 (7.8); 4.0039 (9.2); 4.0013 (7.4); 3.9797 (6.6); 3.3625 (1.4); 3.3401 (3.4); 3.3176 (4.0); 3.2979 (3.6); 3.2759 (1.6); 3.0454 (6.3); 3.0230 (5.2); 3.0029 (9.9); 2.9805 (9.1); 2.8848 (9.8); 2.8612 (9.0); 2.8423 (6.0); 2.8188 (5.4); 1.6779 (4.1); 0.0080 (2.4); -0.0002 (92.6); - 0.0085 (2.7); -0.0499 (0.8) I.2-60: 1 H-NMR (400.0 MHz, CDCl3): δ= 7.3113 (0.7); 7.3069 (0.9); 7.2924 (1.0); 7.2905 (1.1); 7.2881 (1.3); 7.2863 (1.3); 7.2718 (1.2); 7.2672 (2.6); 7.2601 (32.4); 7.2472 (1.7); 7.2431 (1.2); 7.1180 (1.3); 7.1122 (1.4); 7.1002 (1.1); 7.0969 (1.7); 7.0918 (0.5); 7.0796 (1.5); 7.0674 (1.0); 7.0657 (0.8); 7.0582 (0.6); 7.0469 (0.7); 7.0120 (1.0); 7.0089 (1.1); 6.9930 (1.4); 6.9899 (1.6); 6.9738 (0.8); 6.9707 (0.9); 6.9651 (1.5); 6.9623 (1.2); 6.9444 (1.3); 6.9415 (1.1); 4.5671 (2.2); 4.5523 (2.1); 3.9973 (1.0); 3.9819 (1.0); 3.9724 (1.5); 3.9570 (1.5); 3.8965 (1.5); 3.8761 (1.7); 3.8717 (1.1); 3.8512 (1.0); 3.7881 (16.0); 3.2466 (0.8); 2.8907 (0.6); 2.8728 (0.6); 2.8483 (1.9); 2.8304 (1.8); 2.8163 (1.9); 2.7929 (1.8); 2.7739 (0.6); 2.7505 (0.6); -0.0002 (12.7) I.2-61: 1 H-NMR (400.0 MHz, CDCl 3 ): δ= 7.5492 (3.1); 7.5434 (1.1); 7.5373 (3.2); 7.5317 (1.8); 7.5262 (3.3); 7.5198 (1.2); 7.5143 (3.2); 7.2596 (103.2); 7.1450 (0.7); 7.1393 (1.4); 7.1345 (0.8); 7.1276 (0.7); 7.1207 (1.2); 7.1155 (2.9); 7.1013 (2.3); 7.0936 (2.0); 7.0825 (1.6); 7.0805 (1.5); 7.0775 (3.8); 7.0722 (1.8); 7.0658 (0.9); 7.0601 (1.6); 7.0569 (4.6); 7.0546 (3.8); 7.0453 (0.6); 7.0397 (1.1); 7.0339 (3.1); 6.9956 (0.6); 5.9914 (0.6); 4.5727 (3.1); 4.5578 (3.0); 4.1673 (1.7); 4.1489 (1.9); 4.1433 (2.2); 4.1249 (2.2); 3.9427 (2.2); 3.9211 (2.6); 3.9186 (2.1); 3.8971 (1.8); 3.1899 (1.0); 3.1715 (1.0); 3.1688 (1.2); 3.1663 (1.2); 3.1478 (1.1); 2.9551 (1.5); 2.9336 (1.2); 2.9127 (2.8); 2.8912 (2.5); 2.8344 (2.8); 2.8105 (2.5); 2.7920 (1.4); 2.7681 (1.2); 1.5434 (16.0); 0.0080 (1.1); -0.0002 (36.1); -0.0085 (1.1) I.2-62: 1 H-NMR (400.0 MHz, CDCl3): δ= 7.5551 (0.5); 7.5462 (4.4); 7.5404 (1.5); 7.5343 (4.5); 7.5287 (2.6); 7.5231 (4.8); 7.5170 (1.6); 7.5112 (4.6); 7.4093 (3.2); 7.4038 (1.5); 7.4015 (2.8); 7.3975 (3.8); 7.3960 (3.0); 7.3913 (1.6); 7.3858 (4.4); 7.3769 (0.7); 7.2910 (1.0); 7.2870 (0.6); 7.2798 (5.0); 7.2779 (5.0); 7.2727 (3.0); 7.2679 (4.1); 7.2661 (4.3); 7.2596 (114.1); 7.2557 (8.4); 7.0821 (0.6); 7.0732 (5.1); 7.0673 (1.7); 7.0615 (0.7); 7.0558 (1.8); 7.0526 (5.8); 7.0502 (5.0); 7.0469 (1.7); 7.0412 (0.6); 7.0354 (1.4); 7.0295 (4.4); 6.9956 (0.6); 6.0423 (0.9); 4.5866 (8.5); 4.5718 (8.2); 4.1655 (2.6); 4.1470 (2.7); 4.1414 (3.1); 4.1229 (3.2); 3.9350 (3.0); 3.9135 (3.7); 3.9110 (3.0); 3.8895 (2.6); 3.7847 (1.5); 3.2102 (0.6); 3.1885 (1.4); 3.1700 (1.4); 3.1675 (1.6); 3.1649 (1.6); 3.1464 (1.5); 3.1435 (0.9); 3.1249 (0.7); 2.9576 (2.3); 2.9360 (1.8); 2.9152 (4.0); 2.8936 (3.5); 2.8266 (4.0); 2.8028 (3.5); 2.7842 (2.2); 2.7604 (1.9); 1.5486 (16.0); 0.0079 (1.2); -0.0002 (41.1); -0.0085 (1.3) I.2-63: 1 H-NMR (400.0 MHz, CDCl3): δ= 8.5469 (3.9); 8.5444 (4.5); 8.5427 (4.6); 8.5403 (4.0); 8.5346 (4.1); 8.5322 (4.5); 8.5304 (4.4); 8.5280 (3.8); 7.7052 (4.0); 7.7008 (4.0); 7.6860 (7.3); 7.6815 (7.3); 7.6668 (4.8); 7.6624 (4.6); 7.5227 (0.7); 7.2637 (133.3); 7.2439 (8.4); 7.2427 (8.6); 7.2303 (3.7); 7.2289 (3.4); 7.2276 (3.4); 7.2256 (2.8); 7.2239 (3.7); 7.2212 (2.9); 7.2115 (3.3); 7.2102 (3.0); 7.2088 (2.8); 7.0238 (2.2); 6.9997 (1.2); 4.5821 (16.0); 4.5704 (15.7); 4.5374 (1.0); 4.5167 (3.5); 4.4965 (4.7); 4.4765 (2.9); 4.4567 (0.7); 3.6664 (4.3); 3.6481 (4.8); 3.6422 (6.6); 3.6239 (7.0); 3.5586 (6.8); 3.5370 (8.2); 3.5347 (5.6); 3.5128 (5.0); 3.1933 (1.4); 3.1749 (1.8); 3.1719 (3.3); 3.1536 (3.2); 3.1508 (3.9); 3.1480 (3.7); 3.1297 (3.4); 3.1267 (2.1); 3.1084 (1.5); 2.7938 (4.7); 2.7726 (4.2); 2.7520 (9.3); 2.7308 (8.7); 2.6794 (9.8); 2.6554 (9.1); 2.6376 (4.9); 2.6136 (4.4); 2.1074 (1.4); 1.8792 (1.0); 1.8659 (2.1); 1.8619 (2.1); 1.8541 (3.6); 1.8503 (2.8); 1.8456 (2.9); 1.8429 (2.9); 1.8340 (4.2); 1.8228 (2.4); 1.8130 (1.6); 1.8084 (2.0); 1.7278 (0.8); 1.7169 (1.5); 1.7104 (2.1); 1.7041 (2.9); 1.6937 (4.3); 1.6898 (5.0); 1.6821 (4.5); 1.6734 (5.5); 1.6685 (4.7); 1.6522 (3.1); 1.6396 (3.1); 1.6301 (1.6); 1.6207 (2.7); 1.6148 (3.3); 1.6085 (3.1); 1.6061 (3.4); 1.6007 (3.8); 1.5866 (4.6); 1.5783 (5.5); 1.5731 (3.7); 1.5624 (2.5); 1.5521 (2.4); 1.5433 (1.7); 1.5343 (1.6); 1.5222 (1.9); 1.5095 (1.5); 1.5019 (1.8); 1.4912 (1.7); 1.4725 (1.4); 0.0080 (1.4); -0.0002 (51.4); -0.0085 (1.5) I.2-64: 1 H-NMR (400.0 MHz, CDCl 3 ): δ= 8.5566 (4.0); 8.5524 (4.7); 8.5499 (4.2); 8.5443 (4.3); 8.5419 (4.8); 8.5377 (4.1); 7.7210 (3.9); 7.7165 (3.9); 7.7018 (7.3); 7.6974 (7.0); 7.6826 (4.8); 7.6781 (4.6); 7.5810 (1.0); 7.5720 (10.6); 7.5663 (3.9); 7.5601 (11.2); 7.5545 (6.7); 7.5489 (12.2); 7.5428 (4.3); 7.5370 (11.8); 7.5281 (1.5); 7.5191 (1.9); 7.2796 (7.3); 7.2602 (304.7); 7.2461 (5.8); 7.2448 (5.4); 7.2434 (5.4); 7.2414 (4.7); 7.2396 (5.2); 7.2370 (4.5); 7.2273 (4.6); 7.1111 (2.3); 7.0899 (2.1); 7.0811 (12.8); 7.0752 (4.2); 7.0693 (2.1); 7.0637 (5.1); 7.0604 (14.4); 7.0579 (12.9); 7.0546 (4.6); 7.0489 (1.9); 7.0431 (4.1); 7.0372 (11.3); 7.0283 (1.3); 6.9962 (1.8); 4.6152 (16.0); 4.6036 (16.0); 4.2000 (6.3); 4.1813 (6.9); 4.1760 (7.8); 4.1573 (8.1); 3.9926 (7.6); 3.9710 (9.3); 3.9686 (7.4); 3.9470 (6.6); 3.3593 (1.4); 3.3375 (3.5); 3.3187 (3.6); 3.3165 (3.9); 3.3142 (3.9); 3.2954 (3.7); 3.2924 (2.3); 3.2737 (1.6); 3.0282 (5.7); 3.0064 (4.8); 2.9857 (9.5); 2.9638 (8.7); 2.8820 (9.5); 2.8583 (8.8); 2.8394 (5.6); 2.8158 (5.0); 1.6538 (2.2); 1.2553 (0.9); 0.0079 (4.0); -0.0002 (109.2); -0.0085 (3.6) I.2-65: 1 H-NMR (600.1 MHz, CD3CN): δ= 8.5099 (4.8); 8.5088 (4.9); 8.5019 (5.0); 8.5008 (4.9); 7.7267 (3.6); 7.7237 (3.7); 7.7139 (6.9); 7.7109 (6.9); 7.7011 (4.1); 7.6981 (4.1); 7.2815 (7.2); 7.2684 (6.8); 7.2333 (3.7); 7.2324 (3.8); 7.2315 (3.6); 7.2252 (3.8); 7.2243 (4.0); 7.2234 (3.9); 7.2219 (3.2); 7.2208 (4.0); 7.2199 (3.9); 7.2190 (3.6); 7.2127 (3.6); 7.2118 (3.7); 7.2109 (3.4); 7.1179 (1.5); 4.5484 (0.9); 4.5338 (2.3); 4.5197 (4.1); 4.5061 (2.4); 4.5043 (2.4); 4.4904 (1.1); 4.4543 (16.0); 4.4447 (15.9); 3.6815 (5.3); 3.6657 (8.5); 3.6511 (7.3); 3.5582 (6.7); 3.5478 (7.1); 3.5422 (5.4); 3.5318 (5.5); 3.1796 (1.7); 3.1692 (1.9); 3.1668 (2.3); 3.1647 (3.0); 3.1564 (2.3); 3.1540 (3.3); 3.1521 (3.4); 3.1500 (2.5); 3.1414 (2.9); 3.1396 (2.4); 3.1372 (2.0); 3.1267 (1.6); 2.5327 (1.4); 2.5199 (1.7); 2.5049 (12.6); 2.4985 (13.0); 2.4922 (12.0); 2.4831 (12.1); 2.4707 (1.5); 2.4554 (1.7); 2.2529 (0.8); 2.2505 (0.6); 2.2474 (0.9); 2.2404 (0.7); 2.2365 (2.6); 2.2336 (2.6); 2.2311 (3.3); 2.2243 (1.7); 2.2198 (3.5); 2.2175 (4.6); 2.2145 (4.6); 2.2124 (3.9); 2.2080 (1.9); 2.2011 (3.5); 2.1981 (3.0); 2.1954 (2.9); 2.1845 (1.2); 2.1814 (0.8); 2.1790 (1.1); 2.1385 (85.9); 2.0632 (0.4); 2.0606 (0.4); 2.0572 (1.0); 2.0540 (1.2); 2.0499 (2.6); 2.0459 (3.4); 2.0441 (3.2); 2.0419 (2.1); 2.0382 (4.6); 2.0331 (5.2); 2.0313 (4.5); 2.0262 (5.2); 2.0206 (4.1); 2.0185 (3.4); 2.0138 (3.4); 2.0080 (1.8); 2.0058 (1.3); 2.0035 (1.0); 2.0011 (1.1); 1.9952 (0.4); 1.9633 (8.2); 1.9552 (8.9); 1.9511 (10.1); 1.9472 (58.1); 1.9432 (102.5); 1.9390 (148.1); 1.9349 (100.8); 1.9308 (50.4); 1.9220 (1.0); 1.8281 (0.6); 1.8240 (0.8); 1.8199 (0.6); 1.7218 (0.5); 1.7093 (0.7); 1.7040 (1.8); 1.6914 (3.2); 1.6868 (3.8); 1.6822 (2.2); 1.6805 (2.8); 1.6744 (5.8); 1.6694 (3.4); 1.6662 (4.2); 1.6646 (4.6); 1.6629 (4.0); 1.6608 (2.9); 1.6593 (2.9); 1.6575 (3.2); 1.6551 (1.4); 1.6532 (1.6); 1.6502 (2.2); 1.6486 (2.6); 1.6465 (2.3); 1.6445 (1.5); 1.6431 (1.3); 1.6370 (0.3); 1.6322 (0.4); 1.6307 (0.3); -0.0001 (10.2); -0.0057 (0.4) I.2-66: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.6963 (1.2); 8.6821 (2.1); 8.6681 (1.0); 7.7120 (1.2); 7.7041 (10.6); 7.6985 (3.0); 7.6869 (3.6); 7.6813 (12.6); 7.6733 (1.1); 7.6591 (2.0); 7.6522 (3.7); 7.6452 (2.1); 7.5111 (2.2); 7.5087 (4.3); 7.5045 (2.8); 7.4907 (2.9); 7.4865 (6.1); 7.4842 (2.7); 7.4643 (2.8); 7.4599 (1.0); 7.4429 (5.4); 7.4400 (16.0); 7.4345 (3.5); 7.4228 (3.6); 7.4174 (12.2); 7.4091 (1.3); 7.4006 (14.9); 7.3965 (4.0); 7.3825 (3.7); 7.3760 (1.8); 7.3650 (2.1); 7.3585 (1.4); 7.3441 (2.8); 7.3376 (2.6); 7.3231 (0.9); 7.3165 (1.0); 4.3713 (6.6); 4.3571 (6.4); 4.2897 (0.5); 4.2746 (0.6); 4.0594 (2.2); 4.0379 (3.7); 4.0351 (3.8); 4.0137 (3.7); 3.9168 (2.9); 3.9020 (3.0); 3.8925 (2.1); 3.8778 (2.3); 3.8265 (6.8); 3.3225 (62.5); 2.8283 (2.2); 2.8050 (2.2); 2.7860 (3.8); 2.7625 (3.4); 2.6962 (3.7); 2.6789 (4.2); 2.6748 (2.1); 2.6701 (2.6); 2.6655 (1.8); 2.6538 (1.9); 2.6364 (1.9); 2.5508 (0.9); 2.5348 (1.3); 2.5237 (7.6); 2.5190 (10.5); 2.5103 (143.4); 2.5057 (315.4); 2.5010 (445.4); 2.4964 (310.1); 2.4918 (136.1); 2.4600 (2.6); 2.4556 (4.1); 2.4511 (5.1); 2.4465 (3.8); 2.4065 (0.7); 2.3324 (2.1); 2.3279 (2.8); 2.3232 (2.0); 2.0734 (1.1); 1.4995 (1.5); 1.4767 (3.0); 0.9406 (2.0); 0.9264 (2.9); 0.9232 (3.8); 0.9051 (1.3); 0.8826 (0.6); 0.8583 (0.8); -0.0002 (10.5) I.2-67: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.7285 (1.5); 8.7136 (2.7); 8.6995 (1.4); 8.3359 (5.4); 8.3311 (5.1); 7.7665 (3.9); 7.7602 (3.7); 7.7459 (4.4); 7.7396 (4.2); 7.7120 (1.5); 7.7039 (13.0); 7.6984 (3.9); 7.6868 (4.3); 7.6812 (15.3); 7.6732 (1.3); 7.4994 (7.1); 7.4775 (5.9); 7.4437 (1.8); 7.4358 (16.0); 7.4303 (4.1); 7.4186 (3.8); 7.4131 (13.1); 7.4051 (1.0); 5.7554 (1.1); 4.3365 (8.3); 4.3220 (8.2); 4.0297 (2.6); 4.0054 (4.5); 3.9838 (3.7); 3.8975 (3.8); 3.8823 (4.1); 3.8732 (2.8); 3.8580 (2.8); 3.3701 (1.0); 3.3187 (399.0); 3.2906 (2.9); 3.2690 (4.0); 3.2517 (0.9); 3.2189 (0.5); 2.7965 (2.5); 2.7732 (2.3); 2.7540 (5.0); 2.7308 (4.7); 2.6924 (5.3); 2.6745 (6.8); 2.6699 (3.4); 2.6655 (2.2); 2.6500 (2.2); 2.6320 (2.4); 2.5556 (1.3); 2.5234 (8.8); 2.5187 (12.8); 2.5101 (164.1); 2.5055 (357.8); 2.5009 (501.3); 2.4963 (353.8); 2.4917 (160.4); 2.4556 (3.5); 2.4512 (3.8); 2.4011 (1.0); 2.3323 (2.4); 2.3277 (3.2); 2.3230 (2.3); 2.0735 (1.6); 0.0080 (2.5); -0.0002 (92.6); -0.0085 (3.0); -0.0499 (0.6) I.2-68: 1 H-NMR (400.0 MHz, CDCl3): δ= 7.5195 (1.6); 7.4057 (3.9); 7.3958 (1.5); 7.3915 (5.0); 7.3827 (8.0); 7.3706 (18.8); 7.3649 (20.2); 7.3470 (5.4); 7.3284 (16.9); 7.3071 (28.4); 7.2607 (270.8); 7.2485 (15.5); 7.2422 (13.8); 7.2271 (9.0); 7.2209 (8.2); 6.9966 (1.6); 6.9373 (3.3); 6.9346 (2.0); 6.9301 (5.2); 6.9276 (6.5); 6.9238 (6.7); 6.9178 (9.2); 6.9154 (5.3); 6.9102 (10.4); 6.9082 (10.8); 6.9028 (8.2); 6.8968 (13.2); 6.8904 (10.4); 6.8836 (2.1); 6.8762 (6.6); 6.8694 (4.0); 6.1072 (3.8); 4.5768 (1.2); 4.5618 (1.2); 4.5392 (15.9); 4.5337 (16.0); 4.5242 (15.6); 4.5186 (15.6); 4.4963 (1.1); 4.4811 (1.1); 4.0477 (5.9); 4.0296 (6.5); 4.0236 (9.3); 4.0056 (9.4); 3.9395 (10.3); 3.9180 (12.2); 3.8943 (7.2); 3.2999 (2.2); 3.2790 (5.3); 3.2609 (5.3); 3.2582 (6.8); 3.2555 (6.1); 3.2375 (5.6); 3.2167 (2.4); 2.9298 (8.6); 2.9092 (7.5); 2.8872 (15.3); 2.8666 (14.2); 2.8004 (15.0); 2.7768 (13.9); 2.7579 (8.1); 2.7343 (7.3); 1.5678 (4.4); 1.2577 (0.8); 0.0079 (3.2); -0.0002 (101.3); - 0.0085 (2.9) I.2-69: 1 H-NMR (400.0 MHz, CDCl 3 ): δ= 8.7236 (2.9); 7.9669 (3.1); 7.9655 (3.2); 7.9620 (3.1); 7.5196 (1.4); 7.3110 (0.8); 7.2775 (0.6); 7.2767 (0.7); 7.2751 (0.8); 7.2744 (0.8); 7.2727 (1.0); 7.2720 (1.2); 7.2711 (1.2); 7.2687 (2.4); 7.2680 (2.5); 7.2672 (2.8); 7.2663 (3.3); 7.2655 (4.2); 7.2647 (5.2); 7.2607 (255.0); 7.2566 (2.5); 7.2557 (1.4); 7.2549 (1.1); 7.2541 (0.8); 7.2533 (0.5); 7.2105 (1.8); 7.0812 (0.9); 6.9967 (1.4); 4.7451 (4.0); 4.7344 (3.9); 3.7383 (1.9); 3.7211 (2.1); 3.7139 (2.6); 3.6966 (2.7); 3.5906 (2.7); 3.5689 (3.3); 3.5662 (2.4); 3.5444 (2.3); 3.2811 (0.5); 3.2602 (0.9); 3.2394 (1.4); 3.2187 (1.0); 3.2149 (0.7); 3.1977 (0.5); 3.1758 (0.8); 3.1564 (0.8); 3.1421 (2.5); 3.1226 (2.6); 3.1111 (2.4); 3.0928 (2.4); 3.0773 (0.8); 3.0588 (0.8); 2.8336 (1.1); 2.8137 (1.0); 2.7918 (2.6); 2.7716 (2.5); 2.7404 (2.5); 2.7160 (2.3); 2.6980 (1.0); 2.6737 (0.9); 2.1370 (0.6); 1.9670 (0.5); 1.9487 (1.0); 1.9318 (1.4); 1.9151 (1.1); 1.8961 (0.6); 1.5825 (3.0); 0.9278 (16.0); 0.9245 (16.0); 0.9111 (15.9); 0.9078 (15.6); 0.0079 (3.4); 0.0064 (0.9); 0.0055 (1.0); 0.0047 (1.3); -0.0002 (109.2); -0.0051 (1.4); -0.0059 (1.2); -0.0068 (1.0); -0.0085 (3.1); -0.0504 (0.8) I.2-70: 1 H-NMR (400.0 MHz, CDCl3): δ= 8.7233 (11.7); 8.7207 (11.6); 7.9672 (13.0); 7.9658 (13.2); 7.9623 (12.9); 7.9610 (12.2); 7.5198 (4.3); 7.3111 (2.0); 7.2834 (1.1); 7.2785 (1.8); 7.2746 (2.4); 7.2706 (4.1); 7.2610 (763.5); 7.2569 (5.6); 7.2560 (3.4); 7.2552 (2.2); 7.2544 (1.7); 7.2536 (1.2); 7.2527 (1.4); 7.2520 (1.3); 7.2504 (0.9); 7.2496 (0.8); 7.2488 (0.8); 7.2109 (6.9); 7.1610 (0.7); 7.0886 (4.1); 6.9969 (4.5); 4.7429 (15.6); 4.7318 (15.3); 4.6851 (0.6); 4.5543 (1.5); 4.5333 (5.4); 4.5131 (7.2); 4.4930 (4.4); 4.4733 (1.1); 3.6977 (6.5); 3.6799 (7.4); 3.6734 (10.0); 3.6556 (10.7); 3.5894 (10.2); 3.5680 (12.4); 3.5654 (8.2); 3.5437 (7.6); 3.2522 (2.1); 3.2314 (4.7); 3.2136 (4.5); 3.2105 (5.9); 3.2074 (5.3); 3.1895 (4.7); 3.1864 (3.1); 3.1685 (2.1); 2.8173 (6.3); 2.7966 (5.7); 2.7755 (15.2); 2.7548 (14.2); 2.7268 (16.0); 2.7028 (15.1); 2.6850 (6.6); 2.6611 (6.0); 2.1370 (0.8); 1.8691 (5.2); 1.8600 (4.6); 1.8490 (6.1); 1.8238 (3.1); 1.7157 (3.8); 1.7056 (5.6); 1.7012 (6.9); 1.6936 (5.1); 1.6857 (5.8); 1.6800 (4.4); 1.6638 (3.5); 1.6520 (5.2); 1.6277 (8.4); 1.6189 (9.8); 1.6129 (10.3); 1.6024 (9.4); 1.5915 (9.9); 1.5652 (4.2); 1.5377 (3.2); 1.5179 (2.9); 1.5070 (2.7); 1.4884 (2.1); 1.4376 (1.0); 1.4190 (1.7); 1.4006 (0.9); 1.2562 (0.6); 0.1461 (0.9); 0.0690 (2.7); 0.0499 (0.6); 0.0080 (8.8); -0.0002 (343.2); -0.0085 (9.8); -0.0503 (3.3); -0.1498 (0.9) I.2-71: 1 H-NMR (400.0 MHz, CDCl3): δ= 7.5189 (1.1); 7.4090 (1.8); 7.3943 (2.1); 7.3860 (3.3); 7.3712 (3.2); 7.3652 (2.2); 7.3503 (2.2); 7.3101 (0.5); 7.2928 (0.8); 7.2912 (0.8); 7.2888 (0.9); 7.2857 (1.1); 7.2832 (1.2); 7.2816 (1.4); 7.2808 (1.4); 7.2800 (1.5); 7.2792 (1.5); 7.2784 (1.6); 7.2776 (1.7); 7.2768 (1.8); 7.2761 (1.8); 7.2752 (1.9); 7.2745 (2.0); 7.2737 (2.1); 7.2729 (2.2); 7.2721 (2.3); 7.2713 (2.4); 7.2704 (2.7); 7.2697 (2.8); 7.2689 (3.0); 7.2681 (3.3); 7.2672 (3.7); 7.2601 (191.3); 7.2544 (3.2); 7.2535 (2.4); 7.2527 (1.9); 7.2519 (1.5); 7.2511 (1.1); 7.2503 (1.0); 7.2495 (0.8); 7.2487 (0.7); 7.2479 (0.6); 7.1588 (0.9); 7.1535 (1.0); 7.1394 (1.8); 7.1337 (3.4); 7.1288 (2.2); 7.1222 (2.1); 7.1152 (3.1); 7.1097 (6.6); 7.0955 (5.9); 7.0886 (5.1); 7.0776 (3.4); 7.0758 (2.9); 7.0677 (2.5); 7.0640 (1.4); 7.0583 (1.1); 7.0533 (1.3); 7.0482 (0.7); 7.0393 (0.5); 7.0362 (0.6); 6.9960 (1.1); 6.9381 (1.6); 6.9355 (1.1); 6.9311 (2.4); 6.9285 (3.0); 6.9245 (3.1); 6.9186 (4.0); 6.9162 (2.6); 6.9111 (4.5); 6.9091 (4.7); 6.9035 (3.5); 6.8974 (5.6); 6.8913 (4.4); 6.8845 (0.9); 6.8764 (2.6); 6.8702 (1.6); 5.9992 (1.7); 4.5669 (8.4); 4.5520 (8.0); 4.0427 (2.5); 4.0234 (2.9); 4.0185 (4.0); 4.0006 (3.9); 3.9342 (4.3); 3.9124 (5.2); 3.8889 (3.0); 3.2770 (1.0); 3.2562 (2.4); 3.2381 (2.4); 3.2354 (3.0); 3.2327 (2.6); 3.2147 (2.4); 3.1939 (1.0); 2.9285 (3.7); 2.9080 (3.2); 2.8860 (6.4); 2.8654 (5.9); 2.7943 (6.3); 2.7707 (5.8); 2.7518 (3.5); 2.7282 (3.1); 1.5464 (16.0); 1.2583 (0.5); 0.0144 (0.7); 0.0136 (0.8); 0.0080 (2.9); 0.0064 (1.8); -0.0002 (75.2); -0.0085 (2.4) I.2-72: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.7179 (3.3); 8.7035 (5.9); 8.6903 (3.4); 7.6190 (12.0); 7.4690 (3.9); 7.4478 (10.2); 7.4344 (9.8); 7.4154 (16.0); 7.3944 (4.4); 7.3667 (2.2); 7.3474 (4.5); 7.3276 (4.9); 7.3218 (5.2); 7.3080 (3.3); 7.2312 (14.4); 7.2170 (2.8); 7.2058 (2.9); 7.1965 (5.8); 7.1855 (7.5); 7.1782 (9.3); 7.1704 (10.1); 7.0461 (6.8); 6.9611 (5.6); 6.9415 (5.5); 4.3919 (13.8); 4.3780 (14.1); 4.0521 (4.4); 4.0285 (8.4); 4.0061 (5.8); 3.9090 (5.9); 3.8939 (6.3); 3.8838 (5.8); 3.8697 (5.3); 3.3226 (25.2); 2.8171 (4.0); 2.7938 (3.8); 2.7746 (7.5); 2.7512 (6.9); 2.6931 (7.7); 2.6753 (9.2); 2.6510 (4.5); 2.6332 (4.3); 2.5043 (449.7); 2.5001 (613.5); 2.4958 (479.2); 2.3270 (3.8); 1.4336 (2.0); 1.1642 (0.6); 0.9077 (1.8); 0.8898 (2.4); 0.1458 (0.9); -0.0002 (190.4); -0.1496 (0.9) I.2-73: 1 H-NMR (400.0 MHz, CDCl3): δ= 7.8781 (4.0); 7.8571 (4.6); 7.8297 (8.2); 7.5184 (5.0); 7.5098 (3.3); 7.4907 (7.0); 7.4700 (4.6); 7.4229 (9.6); 7.4035 (4.1); 7.3946 (10.8); 7.3884 (11.5); 7.3417 (10.4); 7.3204 (16.9); 7.2935 (4.6); 7.2726 (8.6); 7.2596 (873.2); 7.2412 (5.9); 7.2350 (5.1); 7.1899 (2.8); 7.1836 (2.6); 7.1694 (1.7); 7.1628 (1.6); 6.9956 (4.6); 6.0424 (2.3); 4.5950 (0.9); 4.5580 (11.2); 4.5432 (10.7); 4.5401 (10.6); 4.2300 (5.9); 4.2116 (6.3); 4.2060 (7.3); 4.1875 (7.4); 4.0165 (6.6); 3.9950 (8.4); 3.9925 (6.7); 3.9710 (5.8); 3.9238 (9.6); 3.2502 (1.3); 3.2287 (3.2); 3.2077 (4.0); 3.1866 (3.6); 3.1651 (1.4); 2.9974 (5.2); 2.9759 (4.0); 2.9547 (10.0); 2.9332 (8.8); 2.8842 (9.9); 2.8604 (8.7); 2.8415 (4.7); 2.8178 (4.3); 2.0453 (1.1); 1.5654 (16.0); 1.2837 (1.0); 1.2565 (2.0); 0.1458 (1.0); 0.0079 (10.1); -0.0002 (335.2); -0.0085 (9.6); -0.1495 (1.1) I.2-74: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.7153 (3.8); 8.7013 (6.2); 8.6868 (3.4); 7.9615 (11.1); 7.7503 (6.2); 7.7295 (6.8); 7.5418 (5.7); 7.5221 (10.5); 7.5023 (5.6); 7.3732 (2.2); 7.3665 (2.8); 7.3469 (9.8); 7.3215 (8.8); 7.3077 (2.3); 7.2174 (2.4); 7.1978 (6.1); 7.1851 (10.3); 7.1810 (8.9); 7.1736 (14.0); 7.1617 (6.7); 7.1461 (2.0); 7.0339 (15.3); 6.8945 (7.6); 4.3958 (16.0); 4.3815 (15.7); 4.0807 (5.9); 4.0566 (10.0); 4.0351 (8.0); 3.9381 (8.2); 3.9231 (8.9); 3.9139 (6.4); 3.8990 (6.3); 3.3588 (6.3); 3.3075 (657.4); 3.2827 (2.6); 3.2582 (4.8); 2.8238 (5.9); 2.8005 (5.5); 2.7813 (11.2); 2.7581 (10.3); 2.7044 (11.7); 2.6868 (10.8); 2.6739 (6.8); 2.6692 (10.1); 2.6622 (8.3); 2.6444 (6.2); 2.5551 (13.6); 2.5505 (14.7); 2.5456 (14.4); 2.5227 (65.2); 2.5179 (83.1); 2.5093 (562.0); 2.5048 (1152.6); 2.5002 (1565.7); 2.4956 (1106.5); 2.4910 (506.6); 2.4688 (3.6); 2.4554 (7.4); 2.4507 (9.0); 2.4460 (6.2); 2.3997 (1.8); 2.3317 (6.8); 2.3270 (9.2); 2.3224 (6.6); 1.2339 (1.5); 0.1458 (2.2); 0.0498 (3.1); 0.0080 (24.0); -0.0002 (669.3); -0.0085 (22.5); -0.0326 (1.3); -0.0497 (4.0); -0.1495 (2.2) I.2-75: 1 H-NMR (400.0 MHz, CDCl 3 ): δ= 7.5021 (0.8); 7.4967 (1.6); 7.4912 (0.9); 7.4202 (0.6); 7.4129 (1.4); 7.4057 (1.1); 7.4002 (1.9); 7.3967 (1.4); 7.3943 (1.7); 7.3918 (2.0); 7.3603 (1.3); 7.3400 (1.9); 7.3195 (0.8); 7.2839 (1.8); 7.2823 (1.8); 7.2769 (1.1); 7.2724 (1.5); 7.2705 (1.6); 7.2662 (1.6); 7.2595 (79.6); 6.9288 (0.6); 6.9088 (0.6); 6.7030 (1.3); 6.5184 (2.6); 6.3338 (1.3); 4.5912 (3.2); 4.5763 (3.1); 4.1732 (0.9); 4.1545 (0.9); 4.1490 (1.1); 4.1304 (1.1); 3.9622 (1.0); 3.9406 (1.3); 3.9382 (1.0); 3.9165 (0.9); 3.1872 (0.5); 3.1640 (0.6); 3.1451 (0.6); 2.9825 (0.9); 2.9607 (0.6); 2.9399 (1.5); 2.9181 (1.2); 2.8436 (1.4); 2.8199 (1.3); 2.8010 (0.8); 2.7773 (0.7); 1.5385 (16.0); 0.0080 (0.9); -0.0002 (27.6); -0.0085 (0.8) I.2-76: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.3883 (1.5); 8.3768 (2.9); 8.3657 (1.5); 7.6210 (5.6); 7.6159 (3.5); 7.5178 (8.9); 7.5163 (9.0); 7.4970 (16.0); 7.4620 (1.1); 7.4562 (1.6); 7.4514 (1.2); 7.4394 (4.2); 7.4352 (7.4); 7.4307 (8.3); 7.4169 (5.0); 7.4128 (6.0); 7.4003 (6.9); 7.3922 (2.1); 7.3818 (5.4); 7.3786 (4.9); 7.3601 (4.0); 7.2318 (9.1); 7.0467 (4.6); 6.9590 (2.6); 6.9532 (1.8); 6.9405 (2.6); 5.7530 (1.8); 4.5530 (6.1); 4.5497 (6.2); 4.5414 (6.1); 4.5381 (6.1); 4.4836 (0.6); 4.4707 (0.6); 4.0187 (2.1); 3.9944 (3.9); 3.9729 (3.1); 3.8856 (3.2); 3.8713 (3.3); 3.8613 (2.4); 3.8469 (2.4); 3.3091 (134.7); 3.2587 (2.3); 3.2433 (1.3); 3.2356 (1.2); 3.2216 (0.8); 2.7826 (2.3); 2.7592 (2.2); 2.7401 (4.4); 2.7167 (4.0); 2.6739 (2.8); 2.6692 (4.2); 2.6645 (7.1); 2.6472 (4.3); 2.6219 (2.4); 2.6047 (2.5); 2.5454 (1.6); 2.5227 (10.8); 2.5180 (15.8); 2.5094 (211.5); 2.5048 (459.9); 2.5002 (640.4); 2.4956 (457.2); 2.4910 (210.2); 2.3316 (2.7); 2.3270 (3.7); 2.3224 (2.7); 2.3179 (1.3); 2.0721 (1.0); 1.3578 (6.4); 0.8659 (0.7); 0.1461 (1.3); 0.0080 (10.2); -0.0002 (344.1); -0.0085 (10.9); -0.1497 (1.3) I.2-77: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.3899 (1.4); 8.3787 (2.7); 8.3676 (1.4); 7.9616 (4.2); 7.7397 (2.1); 7.7369 (2.0); 7.7216 (2.0); 7.7190 (2.6); 7.7162 (2.6); 7.5366 (3.1); 7.5161 (13.3); 7.4970 (16.0); 7.4805 (0.8); 7.4624 (1.4); 7.4591 (1.7); 7.4434 (1.3); 7.4381 (1.1); 7.4189 (1.7); 7.4004 (7.5); 7.3819 (5.1); 7.3787 (5.5); 7.3602 (3.8); 7.3421 (3.4); 7.3344 (1.4); 7.3225 (2.6); 7.3160 (1.2); 7.3126 (0.8); 7.2940 (0.5); 7.1743 (2.8); 7.0348 (6.0); 6.8953 (2.9); 4.5556 (7.8); 4.5439 (7.7); 4.2285 (0.5); 4.2090 (0.6); 4.1039 (5.4); 4.0482 (2.3); 4.0265 (3.5); 4.0242 (4.0); 4.0027 (3.1); 3.9130 (3.2); 3.8985 (3.3); 3.8888 (2.4); 3.8744 (2.5); 3.6012 (0.5); 3.4936 (0.7); 3.3127 (0.8); 3.2955 (1.2); 3.2906 (1.3); 3.2810 (1.2); 3.2745 (2.0); 3.2587 (1.3); 3.2533 (1.1); 3.2364 (0.7); 2.7891 (2.1); 2.7658 (2.0); 2.7467 (4.2); 2.7234 (3.8); 2.6776 (4.4); 2.6696 (1.3); 2.6604 (4.2); 2.6351 (2.0); 2.6179 (1.9); 2.5231 (2.7); 2.5184 (3.9); 2.5097 (53.4); 2.5051 (116.3); 2.5005 (163.1); 2.4959 (116.3); 2.4914 (53.3); 2.3320 (0.7); 2.3273 (1.0); 2.3227 (0.7); 1.4582 (0.9); 1.4226 (0.5); 0.9357 (0.5); 0.9192 (1.1); 0.9094 (0.8); 0.8887 (1.1); 0.8855 (1.0); 0.8705 (2.2); 0.8673 (2.2); 0.8524 (1.6); 0.8492 (1.7); 0.0080 (3.0); -0.0002 (98.2); -0.0085 (2.9) I.2-78: 1 H-NMR (400.0 MHz, CDCl 3 ): δ= 7.5184 (0.7); 7.4085 (1.4); 7.3981 (1.7); 7.3935 (2.6); 7.3850 (2.3); 7.3824 (2.1); 7.3700 (1.0); 7.3637 (0.7); 7.3488 (0.6); 7.2881 (0.6); 7.2765 (2.6); 7.2695 (2.1); 7.2596 (129.6); 7.2531 (4.0); 6.9956 (0.7); 6.9256 (0.8); 6.9220 (0.8); 6.9156 (1.0); 6.9062 (1.3); 6.9009 (1.0); 6.8948 (1.5); 6.8882 (1.2); 6.8739 (0.8); 4.5857 (4.1); 4.5709 (4.0); 4.0456 (0.7); 4.0272 (0.8); 4.0220 (1.1); 4.0037 (1.1); 3.9303 (1.3); 3.9089 (1.5); 3.8850 (0.9); 3.2560 (0.6); 3.2351 (0.8); 3.2144 (0.7); 2.9371 (1.1); 2.9164 (0.9); 2.8946 (1.8); 2.8739 (1.7); 2.7921 (1.8); 2.7686 (1.6); 2.7496 (1.0); 2.7260 (0.9); 1.5369 (16.0); 0.0079 (1.5); - 0.0002 (45.8); -0.0084 (1.4) I.2-79: 1 H-NMR (400.0 MHz, CDCl3): δ= 7.5562 (1.4); 7.5473 (10.2); 7.5415 (3.9); 7.5354 (10.5); 7.5299 (6.3); 7.5243 (11.0); 7.5184 (5.4); 7.5124 (10.4); 7.5035 (1.1); 7.3655 (14.8); 7.3449 (25.1); 7.3084 (0.8); 7.2886 (1.4); 7.2597 (361.7); 7.2414 (10.0); 7.2228 (8.3); 7.2198 (7.1); 7.2012 (5.5); 7.0815 (1.4); 7.0726 (11.2); 7.0668 (3.7); 7.0609 (2.2); 7.0551 (5.0); 7.0520 (13.5); 7.0496 (11.6); 7.0462 (4.1); 7.0406 (1.7); 7.0347 (3.5); 7.0289 (9.8); 7.0201 (0.8); 6.9957 (1.9); 5.8324 (2.3); 4.8656 (0.6); 4.8524 (0.7); 4.8306 (11.8); 4.8272 (11.3); 4.8170 (11.2); 4.8135 (10.9); 4.7921 (0.6); 4.7783 (0.6); 4.6906 (0.7); 4.1869 (5.7); 4.1683 (6.3); 4.1628 (7.0); 4.1442 (6.9); 3.9275 (6.7); 3.9059 (8.4); 3.9036 (6.8); 3.8819 (5.9); 3.1923 (1.1); 3.1706 (3.2); 3.1519 (3.5); 3.1495 (3.9); 3.1469 (3.7); 3.1283 (3.6); 3.1067 (1.5); 2.9666 (5.4); 2.9449 (4.1); 2.9241 (8.7); 2.9024 (7.6); 2.8179 (8.4); 2.7940 (7.6); 2.7754 (4.9); 2.7516 (4.4); 2.6512 (0.8); 1.9903 (0.9); 1.5446 (16.0); 1.2559 (1.2); 1.1636 (0.7); 0.0079 (4.8); -0.0002 (129.2); -0.0085 (4.0) I.2-80: 1 H-NMR (400.0 MHz, CDCl3): δ= 7.5187 (0.8); 7.5073 (1.3); 7.5018 (2.6); 7.4965 (1.5); 7.4228 (0.9); 7.4202 (1.0); 7.4177 (0.8); 7.4150 (0.8); 7.4021 (1.7); 7.3995 (1.8); 7.3970 (1.7); 7.3943 (1.5); 7.3884 (2.7); 7.3821 (2.9); 7.3657 (2.2); 7.3454 (3.3); 7.3390 (2.7); 7.3249 (1.4); 7.3178 (4.4); 7.2598 (150.3); 7.2536 (3.1); 7.2382 (1.4); 7.2320 (1.3); 6.9958 (0.8); 6.9344 (1.0); 6.9310 (1.0); 6.9147 (0.9); 6.9110 (0.9); 6.7062 (2.4); 6.5217 (4.8); 6.3371 (2.5); 6.0477 (0.6); 4.5531 (2.6); 4.5494 (2.6); 4.5381 (2.5); 4.5343 (2.6); 4.1823 (1.5); 4.1637 (1.6); 4.1581 (1.9); 4.1395 (1.9); 3.9776 (1.8); 3.9560 (2.2); 3.9534 (1.7); 3.9319 (1.5); 3.2103 (0.8); 3.1892 (1.0); 3.1681 (0.9); 2.9825 (1.4); 2.9607 (1.1); 2.9399 (2.5); 2.9181 (2.3); 2.8615 (2.5); 2.8378 (2.2); 2.8190 (1.3); 2.7952 (1.1); 1.5440 (16.0); 0.0080 (1.6); -0.0002 (52.8); -0.0085 (1.4) I.2-81: 1 H-NMR (400.0 MHz, CDCl 3 ): δ= 7.4144 (0.7); 7.4091 (0.7); 7.3598 (0.6); 7.3390 (0.7); 7.2597 (66.6); 4.5411 (0.8); 4.5259 (0.8); 2.8763 (0.5); 1.5380 (16.0); 0.0079 (0.7); -0.0002 (23.2); -0.0085 (0.6) I.2-82: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.6770 (2.8); 7.9630 (5.1); 7.7535 (2.8); 7.7358 (3.2); 7.5463 (2.8); 7.5264 (4.9); 7.5079 (7.4); 7.4879 (7.1); 7.4860 (7.4); 7.4014 (16.0); 7.3812 (4.5); 7.3747 (2.6); 7.3465 (3.6); 7.3274 (2.9); 7.1767 (3.4); 7.0370 (7.1); 6.8975 (3.5); 4.3778 (9.0); 4.3633 (8.8); 4.1085 (2.8); 4.0843 (4.6); 4.0630 (3.9); 3.9656 (3.7); 3.9510 (3.9); 3.9413 (2.8); 3.9268 (2.9); 3.4127 (0.9); 3.3904 (1.4); 3.3748 (2.2); 3.3602 (2.3); 3.3106 (277.9); 2.8517 (2.9); 2.8286 (2.8); 2.8094 (5.0); 2.7861 (4.6); 2.7215 (5.1); 2.7044 (4.7); 2.6790 (3.2); 2.6698 (2.0); 2.6619 (3.2); 2.5231 (6.0); 2.5184 (7.9); 2.5097 (117.9); 2.5052 (257.5); 2.5006 (358.3); 2.4959 (249.4); 2.4914 (110.0); 2.3273 (2.2); 1.2356 (1.9); -0.0002 (24.8) I.2-83: 1 H-NMR (400.0 MHz, CDCl3): δ= 8.7245 (8.8); 7.9774 (9.5); 7.9738 (9.6); 7.5796 (10.4); 7.5741 (4.2); 7.5677 (11.1); 7.5623 (6.9); 7.5566 (12.3); 7.5506 (4.6); 7.5447 (11.7); 7.5185 (4.5); 7.3104 (3.1); 7.2979 (3.5); 7.2597 (772.4); 7.1640 (3.8); 7.0913 (12.3); 7.0855 (4.3); 7.0706 (14.4); 7.0683 (13.4); 7.0533 (4.0); 7.0477 (11.4); 6.9956 (4.2); 4.7737 (12.1); 4.7625 (12.4); 4.2270 (6.0); 4.2086 (6.6); 4.2028 (7.7); 4.1845 (8.0); 4.0259 (7.5); 4.0044 (9.0); 4.0019 (7.6); 3.9804 (6.5); 3.4163 (1.5); 3.3949 (3.9); 3.3741 (4.4); 3.3533 (3.8); 3.3313 (1.6); 3.0471 (5.1); 3.0256 (4.7); 3.0046 (9.5); 2.9832 (8.7); 2.9231 (9.8); 2.8994 (9.2); 2.8806 (4.9); 2.8569 (4.3); 1.5508 (16.0); 1.4172 (1.4); 0.0080 (10.0); -0.0002 (272.0); -0.0084 (12.2) I.2-84: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.6670 (6.0); 7.6848 (8.8); 7.6726 (9.9); 7.6624 (10.6); 7.6498 (9.4); 7.6200 (11.7); 7.6154 (11.5); 7.4427 (4.5); 7.4222 (9.3); 7.4176 (8.8); 7.3871 (12.7); 7.3663 (5.9); 7.2337 (9.2); 7.2116 (15.8); 7.1898 (7.8); 4.3586 (16.0); 4.3447 (15.5); 4.0406 (3.8); 4.0178 (7.9); 3.9949 (5.6); 3.9102 (5.4); 3.8949 (6.2); 3.8864 (4.4); 3.8705 (4.1); 3.3094 (372.2); 2.7966 (3.2); 2.7728 (3.2); 2.7541 (7.0); 2.7310 (6.4); 2.6919 (7.6); 2.6739 (9.8); 2.6490 (3.6); 2.6317 (3.4); 2.5004 (645.8); 2.3280 (3.9); -0.0002 (41.5) I.2-85: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.6954 (4.1); 7.7513 (1.1); 7.6844 (6.0); 7.6615 (7.5); 7.6486 (6.2); 7.5072 (4.5); 7.4853 (6.2); 7.4563 (1.8); 7.3986 (16.0); 7.3806 (4.8); 7.3420 (3.1); 7.2340 (6.0); 7.2125 (9.9); 7.1903 (5.3); 4.3726 (10.6); 4.3586 (10.4); 4.2850 (2.0); 4.2690 (2.1); 4.0558 (2.5); 4.0310 (5.4); 4.0100 (3.6); 3.9167 (3.8); 3.9028 (4.2); 3.8791 (2.6); 3.3101 (294.1); 2.8094 (2.6); 2.7866 (2.8); 2.7667 (4.4); 2.7448 (4.5); 2.6857 (5.9); 2.6689 (9.1); 2.6434 (4.6); 2.6249 (5.1); 2.5005 (680.7); 2.3274 (4.4); 0.8529 (1.8); -0.0002 (43.1) I.2-86: 1 H-NMR (400.0 MHz, CDCl 3 ): δ= 7.3537 (2.7); 7.3526 (2.7); 7.3332 (4.7); 7.2937 (0.7); 7.2893 (0.8); 7.2749 (0.9); 7.2730 (0.9); 7.2705 (1.3); 7.2688 (1.4); 7.2604 (35.0); 7.2560 (1.8); 7.2502 (1.3); 7.2406 (1.6); 7.2365 (1.1); 7.2274 (1.9); 7.2088 (1.5); 7.2058 (1.4); 7.1872 (1.1); 6.9960 (1.0); 6.9928 (1.0); 6.9769 (1.3); 6.9738 (1.4); 6.9578 (0.7); 6.9546 (0.8); 6.9465 (1.3); 6.9437 (1.1); 6.9259 (1.2); 6.9232 (1.0); 4.8186 (2.7); 4.8050 (2.6); 4.0121 (1.0); 3.9948 (1.0); 3.9876 (1.4); 3.9703 (1.5); 3.8806 (1.4); 3.8594 (1.6); 3.8561 (1.2); 3.8349 (1.1); 3.7666 (16.0); 3.2246 (0.7); 3.2216 (0.6); 3.2043 (0.5); 2.9299 (1.0); 2.9099 (0.9); 2.8876 (1.6); 2.8677 (1.4); 2.7694 (1.6); 2.7458 (1.5); 2.7271 (1.0); 2.7035 (0.9); 1.5731 (0.5); -0.0002 (12.1) I.2-87: 1 H-NMR (400.0 MHz, CDCl 3 ): δ= 7.5190 (1.1); 7.4036 (2.4); 7.3887 (2.7); 7.3806 (4.6); 7.3657 (5.2); 7.3598 (17.0); 7.3440 (5.0); 7.3394 (23.8); 7.3073 (0.8); 7.2885 (0.7); 7.2844 (0.6); 7.2602 (191.0); 7.2365 (10.7); 7.2179 (8.7); 7.2148 (7.8); 7.1962 (5.8); 6.9962 (1.1); 6.9323 (2.0); 6.9295 (1.4); 6.9253 (2.9); 6.9225 (3.5); 6.9168 (3.8); 6.9106 (5.5); 6.9052 (6.1); 6.9033 (6.0); 6.8956 (4.0); 6.8899 (7.9); 6.8852 (5.2); 6.8839 (5.5); 6.8785 (1.5); 6.8687 (3.8); 6.8622 (2.5); 5.8333 (2.6); 4.8222 (16.0); 4.8086 (15.5); 4.7866 (0.7); 4.7722 (0.5); 4.0547 (3.5); 4.0353 (4.1); 4.0308 (5.3); 4.0126 (5.3); 3.9183 (5.5); 3.8965 (7.2); 3.8730 (4.3); 3.2587 (1.2); 3.2376 (3.2); 3.2191 (3.4); 3.2166 (4.1); 3.2141 (3.7); 3.1958 (3.4); 3.1747 (1.5); 2.9435 (5.4); 2.9226 (4.6); 2.9009 (8.3); 2.8800 (7.6); 2.7736 (8.0); 2.7499 (7.5); 2.7310 (5.2); 2.7073 (4.6); 2.0419 (0.7); 1.5554 (2.4); 1.2579 (0.9); 0.0080 (2.4); -0.0002 (71.8); -0.0085 (3.0) I.2-88: 1 H-NMR (400.0 MHz, CDCl3): δ= 7.7456 (0.9); 7.3973 (0.6); 7.3914 (0.5); 7.2854 (0.9); 7.2782 (0.6); 7.2743 (0.8); 7.2719 (0.8); 7.2680 (0.9); 7.2594 (69.6); 6.6341 (0.7); 4.5960 (1.4); 4.5812 (1.4); 3.9768 (0.6); 2.9520 (0.6); 2.9302 (0.6); 2.8574 (0.6); 2.8336 (0.5); 1.5343 (16.0); 0.0080 (0.8); -0.0002 (24.9); -0.0085 (0.7) I.2-89: 1 H-NMR (400.0 MHz, CDCl3): δ= 8.7265 (5.0); 8.7240 (4.9); 7.9801 (5.3); 7.9788 (5.5); 7.9752 (5.4); 7.9740 (5.0); 7.5877 (1.4); 7.5800 (13.4); 7.5745 (4.2); 7.5629 (4.7); 7.5573 (16.0); 7.5496 (1.7); 7.5205 (0.6); 7.3551 (2.0); 7.3475 (17.1); 7.3419 (4.7); 7.3303 (4.4); 7.3248 (13.5); 7.3171 (1.3); 7.2729 (0.8); 7.2713 (1.0); 7.2697 (1.2); 7.2689 (1.3); 7.2681 (1.5); 7.2616 (102.2); 7.2113 (1.0); 7.1808 (1.8); 6.9976 (0.6); 4.7709 (7.1); 4.7599 (6.9); 4.2214 (4.0); 4.2029 (4.2); 4.1973 (4.9); 4.1788 (5.1); 4.0277 (4.7); 4.0062 (5.8); 4.0036 (4.5); 3.9821 (4.0); 3.4170 (0.8); 3.3953 (2.2); 3.3767 (2.3); 3.3744 (2.5); 3.3720 (2.4); 3.3534 (2.3); 3.3504 (1.4); 3.3318 (0.9); 3.0540 (3.6); 3.0323 (3.0); 3.0113 (6.3); 2.9897 (5.9); 2.9253 (6.4); 2.9017 (5.9); 2.8827 (3.4); 2.8590 (3.1); 2.0448 (0.8); 1.5796 (5.8); 1.2591 (0.6); 0.0080 (1.4); -0.0002 (43.8); -0.0085 (1.3) I.2-90: 1 H-NMR (400.0 MHz, CDCl 3 ): δ= 8.7297 (8.1); 8.7276 (9.7); 8.7250 (9.5); 7.9699 (10.6); 7.9685 (10.9); 7.9650 (10.5); 7.9636 (10.0); 7.5226 (1.0); 7.2781 (0.5); 7.2765 (0.6); 7.2757 (0.6); 7.2749 (0.7); 7.2741 (0.7); 7.2733 (0.9); 7.2725 (1.0); 7.2709 (1.6); 7.2701 (1.9); 7.2693 (2.1); 7.2685 (2.7); 7.2677 (3.2); 7.2637 (189.6); 7.2604 (3.8); 7.2595 (2.4); 7.2587 (1.5); 7.2579 (1.0); 7.2571 (0.7); 7.2562 (0.6); 7.2554 (0.6); 7.2547 (0.5); 7.2138 (1.4); 7.1117 (3.2); 6.9996 (1.1); 4.7481 (13.4); 4.7371 (13.2); 4.7042 (1.1); 4.6833 (3.1); 4.6604 (5.3); 4.6405 (2.9); 4.6167 (1.2); 3.7788 (4.2); 3.7605 (5.0); 3.7546 (10.0); 3.7363 (10.5); 3.7223 (10.3); 3.7009 (11.7); 3.6983 (6.0); 3.6766 (5.0); 3.2646 (1.8); 3.2461 (2.3); 3.2434 (4.2); 3.2407 (2.8); 3.2250 (4.0); 3.2222 (5.2); 3.2193 (4.8); 3.2010 (4.3); 3.1982 (2.8); 3.1797 (1.9); 2.8260 (5.9); 2.8049 (5.3); 2.7840 (12.2); 2.7629 (11.5); 2.7188 (13.0); 2.6947 (12.2); 2.6768 (6.2); 2.6527 (5.6); 2.2580 (0.6); 2.2341 (1.9); 2.2293 (2.6); 2.2082 (3.6); 2.2050 (6.2); 2.2021 (4.1); 2.1807 (7.4); 2.1734 (5.0); 2.1600 (6.6); 2.1562 (7.4); 2.1537 (9.2); 2.1462 (6.2); 2.1428 (5.2); 2.1396 (6.5); 2.1306 (5.7); 2.1264 (6.0); 2.1180 (2.6); 2.1140 (2.1); 2.1060 (1.2); 2.1016 (0.9); 1.7417 (2.0); 1.7359 (1.4); 1.7338 (1.4); 1.7246 (6.4); 1.7170 (3.9); 1.7124 (5.5); 1.7008 (10.1); 1.6922 (2.6); 1.6876 (6.0); 1.6769 (4.8); 1.6645 (1.4); 1.6621 (1.7); 1.6033 (16.0); 1.2560 (0.7); 0.0080 (2.4); 0.0065 (0.8); 0.0057 (0.9); 0.0049 (1.0); 0.0041 (1.2); 0.0024 (3.0); -0.0002 (81.4); -0.0058 (0.6); -0.0085 (2.1); -0.0500 (0.6) I.2-91: 1 H-NMR (400.0 MHz, CDCl3): δ= 8.5555 (4.9); 8.5435 (4.9); 7.8965 (4.0); 7.8761 (4.5); 7.8442 (8.2); 7.7242 (3.2); 7.7198 (3.1); 7.7050 (6.3); 7.7007 (6.0); 7.6858 (3.8); 7.6814 (3.5); 7.5194 (0.9); 7.5081 (2.9); 7.4886 (6.4); 7.4682 (4.1); 7.4173 (5.9); 7.3978 (3.6); 7.2836 (7.0); 7.2606 (132.3); 7.2493 (5.0); 7.2428 (4.1); 7.2303 (3.3); 7.1492 (2.7); 6.9966 (0.7); 4.6194 (16.0); 4.6079 (15.6); 4.2470 (4.8); 4.2283 (5.7); 4.2230 (6.3); 4.2044 (6.2); 4.0562 (5.8); 4.0345 (8.0); 4.0107 (4.8); 3.3810 (1.1); 3.3592 (3.2); 3.3382 (4.0); 3.3174 (3.4); 3.2957 (1.3); 3.0652 (4.5); 3.0435 (3.8); 3.0224 (7.5); 3.0007 (6.8); 2.9155 (7.4); 2.8919 (6.8); 2.8726 (4.3); 2.8490 (3.9); 1.6454 (2.8); 1.2522 (1.6); -0.0002 (47.6); -0.0084 (2.0) I.2-92: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.7249 (3.9); 8.7101 (6.5); 8.6975 (3.3); 8.1750 (12.6); 7.8313 (6.1); 7.8111 (7.0); 7.6398 (4.9); 7.6200 (9.7); 7.5998 (5.2); 7.4993 (8.4); 7.4799 (6.2); 7.3741 (2.0); 7.3675 (2.4); 7.3496 (4.7); 7.3354 (5.1); 7.3294 (3.9); 7.3226 (4.0); 7.3096 (2.1); 7.2177 (2.3); 7.1982 (6.2); 7.1860 (11.2); 7.1778 (10.1); 7.1713 (11.0); 4.3960 (16.0); 4.3817 (15.5); 4.1073 (5.6); 4.0831 (9.5); 4.0616 (8.1); 3.9666 (7.8); 3.9516 (8.4); 3.9421 (5.7); 3.9274 (6.0); 3.3645 (7.3); 3.3140 (679.5); 3.2647 (3.5); 2.8397 (5.5); 2.8165 (5.5); 2.7973 (10.3); 2.7741 (9.5); 2.7161 (10.3); 2.6985 (9.7); 2.6738 (11.4); 2.6698 (9.6); 2.6653 (6.9); 2.6561 (7.0); 2.5518 (9.6); 2.5470 (7.9); 2.5229 (55.5); 2.5096 (562.0); 2.5052 (1074.2); 2.5006 (1387.8); 2.4961 (970.0); 2.4917 (441.8); 2.4608 (8.4); 2.4003 (1.5); 2.3566 (1.9); 2.3320 (6.2); 2.3274 (8.1); 2.3230 (5.6); 2.0726 (1.2); -0.0002 (33.3) I.2-93: 1 H-NMR (400.0 MHz, CDCl 3 ): δ= 7.3630 (1.8); 7.3568 (1.9); 7.3193 (1.9); 7.3082 (0.7); 7.3039 (0.9); 7.2980 (3.1); 7.2894 (0.9); 7.2875 (0.9); 7.2850 (1.1); 7.2833 (1.1); 7.2686 (2.2); 7.2644 (2.8); 7.2604 (29.4); 7.2490 (1.7); 7.2448 (1.2); 7.2352 (1.6); 7.2289 (1.4); 7.2139 (1.0); 7.2077 (0.9); 7.0094 (0.9); 7.0063 (1.0); 6.9904 (1.4); 6.9873 (1.5); 6.9713 (0.7); 6.9681 (0.8); 6.9615 (1.4); 6.9587 (1.2); 6.9408 (1.2); 6.9380 (1.0); 4.5356 (3.2); 4.5205 (3.1); 4.0157 (0.9); 3.9995 (1.0); 3.9910 (1.4); 3.9748 (1.5); 3.9067 (1.4); 3.8860 (1.6); 3.8820 (1.1); 3.8613 (1.0); 3.7866 (16.0); 3.2663 (0.7); 2.9037 (0.7); 2.8850 (0.6); 2.8614 (1.8); 2.8427 (1.6); 2.8139 (1.7); 2.7904 (1.6); 2.7716 (0.7); 2.7480 (0.6); -0.0002 (10.5) I.2-94: 1 H-NMR (400.0 MHz, CDCl 3 ): δ= 8.7615 (0.5); 8.7241 (11.8); 7.9738 (12.4); 7.9697 (12.6); 7.9421 (0.7); 7.8895 (0.5); 7.5192 (2.2); 7.4402 (3.3); 7.4316 (1.2); 7.4252 (4.5); 7.4170 (6.6); 7.4024 (6.4); 7.3961 (4.6); 7.3813 (4.5); 7.3113 (0.6); 7.2892 (0.8); 7.2604 (401.7); 7.2101 (0.7); 7.1587 (4.1); 6.9963 (2.1); 6.9491 (2.8); 6.9395 (6.5); 6.9371 (6.2); 6.9311 (5.2); 6.9271 (3.7); 6.9221 (8.8); 6.9202 (9.6); 6.9159 (7.0); 6.9103 (10.2); 6.9026 (6.8); 6.8956 (1.8); 6.8894 (5.7); 6.8827 (3.4); 5.2985 (0.7); 4.7703 (16.0); 4.7596 (15.7); 4.3860 (0.7); 4.2517 (1.3); 4.1133 (4.9); 4.0941 (5.6); 4.0893 (7.8); 4.0713 (8.0); 4.0138 (8.7); 3.9923 (10.5); 3.9686 (6.0); 3.6197 (0.6); 3.4830 (1.8); 3.4622 (4.7); 3.4414 (5.8); 3.4206 (4.8); 3.3997 (1.9); 3.0187 (7.3); 2.9979 (6.6); 2.9761 (12.9); 2.9553 (12.2); 2.8787 (12.8); 2.8552 (12.2); 2.8361 (7.3); 2.8126 (6.5); 2.1351 (1.0); 1.7417 (0.7); 1.4796 (0.8); 1.2449 (0.7); 0.0695 (0.5); 0.0080 (4.4); -0.0002 (146.2); -0.0085 (4.2); -0.1498 (0.6) I.2-95: 1 H-NMR (400.0 MHz, CDCl3): δ= 8.7259 (10.0); 7.9786 (10.9); 7.9751 (10.9); 7.7773 (14.9); 7.7748 (16.0); 7.7606 (6.6); 7.7579 (7.2); 7.7551 (5.6); 7.5190 (2.8); 7.4910 (3.5); 7.4714 (6.6); 7.4494 (4.4); 7.3264 (7.1); 7.3071 (5.9); 7.2602 (482.4); 7.1850 (4.5); 6.9961 (2.8); 6.7866 (6.1); 6.6456 (12.5); 6.5047 (6.2); 4.7768 (13.4); 4.7660 (13.6); 4.2703 (6.8); 4.2519 (7.7); 4.2461 (9.6); 4.2278 (9.0); 4.0887 (8.4); 4.0672 (10.4); 4.0646 (8.2); 4.0431 (7.0); 3.4327 (1.5); 3.4110 (4.1); 3.3901 (4.8); 3.3877 (4.7); 3.3694 (4.3); 3.3479 (1.9); 3.0935 (0.8); 3.0796 (6.4); 3.0582 (5.6); 3.0369 (11.0); 3.0155 (10.2); 2.9469 (11.0); 2.9234 (10.2); 2.9042 (6.0); 2.8806 (5.5); 1.6381 (2.8); 1.3637 (1.3); 0.0696 (1.0); 0.0080 (5.4); -0.0002 (171.9); -0.0085 (6.7); -0.1496 (0.7) I.2-96: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.7150 (0.8); 8.7001 (1.6); 8.6854 (0.7); 8.3351 (2.9); 8.3303 (2.9); 8.3288 (2.7); 7.7657 (2.1); 7.7593 (2.1); 7.7451 (2.5); 7.7388 (2.4); 7.5289 (5.8); 7.5241 (1.9); 7.5124 (2.1); 7.5075 (6.7); 7.4993 (4.1); 7.4977 (3.9); 7.4787 (3.4); 7.4772 (3.3); 7.1799 (4.7); 7.1594 (4.2); 4.3366 (4.8); 4.3220 (4.7); 4.0046 (1.5); 3.9827 (2.3); 3.9802 (2.7); 3.9586 (2.1); 3.8763 (2.3); 3.8608 (2.4); 3.8519 (1.6); 3.8365 (1.7); 3.3701 (0.8); 3.3204 (93.2); 3.2801 (1.3); 3.2703 (1.1); 3.2635 (1.0); 2.7609 (1.3); 2.7377 (1.2); 2.7187 (3.1); 2.6954 (2.8); 2.6709 (3.7); 2.6653 (0.9); 2.6525 (2.8); 2.6288 (1.1); 2.6103 (1.2); 2.5552 (0.9); 2.5506 (1.2); 2.5456 (1.2); 2.5234 (3.9); 2.5188 (5.3); 2.5101 (56.0); 2.5055 (120.0); 2.5009 (166.7); 2.4962 (116.4); 2.4916 (51.5); 2.4552 (1.0); 2.4507 (1.5); 2.4459 (1.2); 2.4416 (0.7); 2.3323 (0.8); 2.3277 (1.1); 2.3230 (0.9); 2.2748 (16.0); 2.0734 (0.7); 0.1265 (1.3); 0.0081 (1.0); -0.0002 (34.2); -0.0086 (1.0) I.2-97: 1 H-NMR (400.0 MHz, CDCl 3 ): δ= 8.7241 (7.8); 8.7215 (7.7); 7.9759 (8.5); 7.9745 (8.7); 7.9710 (8.6); 7.9697 (8.1); 7.6151 (1.9); 7.6134 (2.3); 7.6108 (11.9); 7.6079 (14.1); 7.6027 (3.7); 7.5937 (4.5); 7.5913 (8.1); 7.5888 (16.0); 7.5861 (13.9); 7.5804 (1.6); 7.5202 (0.9); 7.4045 (1.9); 7.3995 (11.2); 7.3978 (4.8); 7.3943 (3.7); 7.3863 (2.4); 7.3809 (14.2); 7.3783 (10.3); 7.3729 (1.7); 7.3641 (4.1); 7.3614 (4.4); 7.3594 (11.3); 7.3539 (1.4); 7.2733 (0.5); 7.2725 (0.6); 7.2717 (0.7); 7.2709 (0.8); 7.2701 (0.9); 7.2693 (1.0); 7.2685 (1.3); 7.2677 (1.6); 7.2669 (1.8); 7.2613 (162.9); 7.2571 (1.8); 7.2563 (1.2); 7.2555 (0.9); 7.2547 (0.6); 7.2538 (0.6); 7.2531 (0.6); 7.2112 (1.3); 7.1923 (5.4); 7.1895 (8.8); 7.1867 (6.1); 7.1745 (5.0); 7.1728 (5.2); 7.1710 (10.2); 7.1692 (4.8); 7.1673 (3.6); 7.1552 (2.7); 7.1524 (4.5); 7.1496 (2.3); 6.9972 (0.9); 4.7735 (11.1); 4.7625 (11.0); 4.2503 (6.7); 4.2315 (7.2); 4.2260 (8.5); 4.2073 (8.8); 4.0596 (8.2); 4.0381 (9.7); 4.0353 (7.6); 4.0139 (6.9); 3.4200 (1.4); 3.4011 (1.9); 3.3982 (3.6); 3.3793 (3.7); 3.3773 (4.0); 3.3750 (4.1); 3.3561 (3.8); 3.3533 (2.3); 3.3344 (1.6); 3.0629 (6.2); 3.0410 (5.3); 3.0204 (10.5); 2.9986 (9.8); 2.9248 (10.5); 2.9012 (9.9); 2.8823 (6.0); 2.8588 (5.4); 1.5844 (8.5); 0.0080 (2.0); 0.0056 (0.6); 0.0048 (0.8); -0.0002 (68.9); - 0.0085 (1.8) I.2-98: 1 H-NMR (400.0 MHz, CDCl3): δ= 8.7224 (1.4); 8.7200 (1.4); 7.9635 (1.5); 7.9596 (1.5); 7.3080 (2.2); 7.3035 (1.3); 7.2907 (1.9); 7.2882 (2.6); 7.2842 (1.5); 7.2728 (1.3); 7.2684 (0.9); 7.2604 (36.2); 7.2001 (0.5); 7.0163 (0.8); 7.0132 (1.0); 6.9969 (1.2); 6.9942 (1.8); 6.9755 (1.9); 6.9544 (1.2); 6.9511 (0.9); 4.7744 (2.0); 4.7631 (1.9); 4.0791 (0.9); 4.0612 (1.0); 4.0548 (1.5); 4.0368 (1.5); 3.9874 (1.5); 3.9662 (1.7); 3.9630 (1.1); 3.9419 (1.0); 3.8345 (16.0); 3.4461 (0.6); 3.4280 (0.6); 3.4254 (0.7); 3.4227 (0.6); 3.4047 (0.6); 3.0108 (1.0); 2.9903 (0.9); 2.9687 (1.6); 2.9481 (1.5); 2.8635 (1.6); 2.8400 (1.6); 2.8213 (1.0); 2.7978 (0.9); 1.5634 (6.0); - 0.0002 (13.4) I.2-99: 1 H-NMR (400.0 MHz, CDCl3): δ= 8.3042 (3.7); 8.2988 (3.7); 7.6318 (2.8); 7.6254 (2.8); 7.6113 (3.1); 7.6050 (3.1); 7.5214 (0.6); 7.3220 (4.7); 7.3015 (4.3); 7.2625 (107.4); 7.2126 (0.8); 6.9985 (0.6); 6.0973 (1.0); 4.5131 (1.2); 4.4985 (1.1); 4.4903 (1.9); 4.4757 (3.7); 4.4699 (3.0); 4.4607 (3.6); 4.4479 (4.4); 4.4326 (3.5); 4.4099 (1.0); 4.3950 (1.0); 3.6439 (2.1); 3.6262 (2.3); 3.6196 (3.2); 3.6019 (3.2); 3.5262 (3.1); 3.5047 (3.8); 3.5021 (2.8); 3.4804 (2.4); 3.0792 (0.7); 3.0613 (0.9); 3.0581 (1.5); 3.0554 (1.1); 3.0404 (1.5); 3.0373 (2.0); 3.0342 (1.8); 3.0164 (1.6); 3.0132 (1.1); 2.9953 (0.7); 2.7072 (1.5); 2.6865 (1.4); 2.6657 (4.7); 2.6449 (4.4); 2.6322 (4.8); 2.6082 (4.3); 2.5906 (1.6); 2.5666 (1.4); 1.8484 (1.5); 1.8371 (1.6); 1.8189 (1.8); 1.7982 (1.0); 1.6958 (1.9); 1.6887 (2.0); 1.6812 (1.6); 1.6720 (1.9); 1.6492 (1.0); 1.6403 (1.3); 1.6283 (1.0); 1.6216 (1.8); 1.6173 (2.0); 1.6087 (2.0); 1.6013 (2.6); 1.5885 (16.0); 1.5727 (1.8); 1.5580 (1.3); 1.5487 (1.2); 1.5369 (1.0); 1.5279 (1.1); 1.5193 (1.0); 1.5071 (1.0); 1.4987 (1.1); 1.4887 (1.0); 1.4850 (0.9); 1.4782 (1.0); 1.4680 (0.9); 1.4491 (0.7); 0.0080 (1.2); -0.0002 (43.3); -0.0085 (1.5) I.2-100: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.6849 (3.4); 7.6210 (13.3); 7.6160 (11.7); 7.5991 (6.6); 7.5932 (5.7); 7.5798 (4.3); 7.5408 (2.6); 7.4723 (4.5); 7.4496 (8.1); 7.4433 (5.6); 7.4381 (9.7); 7.4224 (9.9); 7.4182 (16.0); 7.3982 (3.9); 7.3920 (9.5); 7.3713 (4.2); 7.2331 (12.6); 7.0480 (6.3); 6.9663 (3.0); 6.9440 (3.3); 4.3593 (8.6); 4.3446 (8.1); 4.0656 (3.6); 4.0407 (5.4); 4.0196 (4.0); 3.9270 (3.6); 3.9125 (4.1); 3.9029 (3.0); 3.8874 (2.9); 3.8636 (8.2); 3.3802 (15.6); 2.8313 (2.4); 2.8082 (2.6); 2.7890 (5.4); 2.7656 (4.7); 2.7136 (4.9); 2.6962 (4.8); 2.6701 (4.8); 2.6537 (2.3); 2.5232 (8.4); 2.5184 (12.7); 2.5097 (204.1); 2.5051 (454.2); 2.5005 (639.7); 2.4959 (456.1); 2.4913 (207.7); 2.3271 (3.4); 1.4615 (3.0); 0.9137 (3.3); -0.0002 (70.9) I.2-101: 1 H-NMR (400.0 MHz, CDCl3): δ= 7.5223 (0.5); 7.4041 (0.8); 7.3936 (4.2); 7.3894 (3.7); 7.3885 (3.6); 7.3860 (4.6); 7.3840 (2.7); 7.3815 (6.1); 7.3787 (4.6); 7.3775 (4.8); 7.3745 (4.7); 7.3705 (6.2); 7.3660 (5.0); 7.3617 (1.2); 7.3565 (0.6); 7.3546 (0.7); 7.2755 (2.0); 7.2732 (1.8); 7.2715 (1.2); 7.2706 (1.4); 7.2698 (1.5); 7.2690 (1.7); 7.2682 (2.0); 7.2635 (96.3); 7.2609 (3.4); 7.2601 (2.4); 7.2591 (2.1); 7.2568 (6.9); 7.2549 (8.1); 7.2510 (6.6); 7.2487 (6.1); 7.2457 (0.9); 7.2412 (13.6); 7.2299 (0.8); 7.2135 (0.6); 6.0633 (1.5); 4.5529 (16.0); 4.5380 (15.5); 4.5085 (0.8); 4.4878 (2.9); 4.4675 (3.8); 4.4474 (2.3); 3.9589 (0.6); 3.6353 (3.4); 3.6174 (3.7); 3.6110 (4.8); 3.5931 (5.0); 3.5063 (5.0); 3.4848 (6.0); 3.4822 (4.3); 3.4605 (3.8); 3.0632 (1.1); 3.0452 (1.4); 3.0420 (2.4); 3.0392 (1.6); 3.0241 (2.3); 3.0210 (3.0); 3.0179 (2.7); 3.0027 (1.4); 3.0000 (2.5); 2.9968 (1.6); 2.9788 (1.2); 2.7195 (3.2); 2.6987 (2.8); 2.6779 (7.4); 2.6570 (6.8); 2.6233 (7.5); 2.5992 (6.9); 2.5817 (3.3); 2.5576 (2.9); 1.8575 (0.7); 1.8545 (0.8); 1.8385 (1.7); 1.8326 (2.3); 1.8293 (2.3); 1.8230 (2.0); 1.8180 (2.0); 1.8144 (2.2); 1.8092 (2.5); 1.8028 (1.9); 1.7994 (2.0); 1.7863 (1.3); 1.7835 (1.1); 1.7187 (0.6); 1.6992 (1.7); 1.6941 (1.9); 1.6829 (3.1); 1.6784 (3.6); 1.6707 (3.0); 1.6654 (2.7); 1.6608 (3.4); 1.6559 (2.6); 1.6468 (1.2); 1.6397 (1.8); 1.6283 (2.1); 1.6182 (1.4); 1.6098 (2.1); 1.6043 (2.7); 1.5954 (2.6); 1.5891 (2.9); 1.5852 (2.7); 1.5786 (2.3); 1.5755 (2.5); 1.5677 (3.1); 1.5624 (2.2); 1.5598 (2.1); 1.5511 (1.9); 1.5379 (1.6); 1.5286 (1.1); 1.5210 (1.5); 1.5151 (1.4); 1.5119 (1.3); 1.4999 (1.4); 1.4945 (1.5); 1.4813 (1.3); 1.4743 (1.4); 1.4629 (1.2); 1.4597 (1.1); 1.4441 (1.0); 0.0079 (1.0); 0.0021 (1.3); -0.0002 (38.2); -0.0028 (1.8); -0.0044 (0.7); -0.0053 (0.5); -0.0085 (1.2) I.2-102: 1 H-NMR (400.0 MHz, CDCl3): δ= 8.5504 (4.5); 8.5480 (5.2); 8.5466 (5.2); 8.5442 (4.5); 8.5382 (4.6); 8.5359 (5.1); 7.7139 (3.7); 7.7095 (3.6); 7.6947 (7.0); 7.6903 (6.7); 7.6755 (4.3); 7.6711 (4.0); 7.4314 (2.3); 7.4223 (1.1); 7.4167 (3.2); 7.4083 (4.6); 7.3936 (4.5); 7.3876 (3.2); 7.3727 (2.9); 7.2742 (8.5); 7.2627 (74.1); 7.2546 (7.8); 7.2384 (4.0); 7.2371 (3.9); 7.2359 (3.8); 7.2320 (3.8); 7.2196 (3.4); 7.2184 (3.1); 7.1258 (2.8); 6.9380 (2.2); 6.9355 (1.5); 6.9309 (3.5); 6.9284 (4.6); 6.9255 (4.3); 6.9195 (4.5); 6.9160 (3.3); 6.9110 (6.5); 6.9090 (6.8); 6.9043 (5.3); 6.8986 (7.1); 6.8914 (5.3); 6.8844 (1.4); 6.8779 (3.6); 6.8712 (2.2); 4.6075 (16.0); 4.5958 (15.2); 4.0851 (3.4); 4.0653 (4.3); 4.0612 (5.5); 4.0427 (5.4); 3.9775 (5.9); 3.9555 (7.6); 3.9322 (4.1); 3.4254 (1.3); 3.4041 (3.4); 3.3832 (4.3); 3.3624 (3.4); 3.3411 (1.3); 2.9958 (5.1); 2.9746 (4.6); 2.9532 (8.1); 2.9321 (7.6); 2.8351 (8.0); 2.8116 (7.6); 2.7925 (4.9); 2.7690 (4.4); 1.7272 (0.7); 1.2562 (1.1); 0.0080 (1.6); -0.0002 (29.2); -0.0085 (0.9) I.2-103: 1 H-NMR (400.0 MHz, CDCl 3 ): δ= 8.7336 (15.9); 8.7213 (16.0); 7.5214 (0.8); 7.2706 (1.3); 7.2689 (1.7); 7.2626 (151.3); 7.2584 (2.6); 7.2568 (1.1); 7.2559 (0.8); 7.2551 (0.8); 7.2543 (0.6); 7.2535 (0.6); 7.2527 (0.6); 7.2495 (4.5); 7.2479 (6.3); 7.2373 (2.1); 7.2355 (3.1); 7.2127 (1.2); 6.9985 (0.9); 6.8999 (1.0); 4.7451 (3.6); 4.7415 (3.6); 4.7336 (3.8); 4.7300 (3.7); 4.7012 (0.7); 4.6815 (1.4); 4.6576 (2.3); 4.6377 (1.2); 4.6138 (0.5); 3.7889 (2.0); 3.7705 (2.4); 3.7647 (3.9); 3.7501 (1.1); 3.7462 (4.2); 3.7160 (4.1); 3.6943 (4.7); 3.6701 (2.4); 3.2455 (0.7); 3.2241 (1.7); 3.2056 (1.7); 3.2029 (2.0); 3.2001 (1.9); 3.1816 (1.8); 3.1600 (0.8); 2.8395 (2.5); 2.8182 (2.2); 2.7975 (4.6); 2.7762 (4.3); 2.7125 (5.1); 2.6884 (4.9); 2.6706 (2.8); 2.6464 (2.5); 2.2335 (0.9); 2.2286 (1.2); 2.2243 (0.6); 2.2087 (1.6); 2.2043 (2.5); 2.2002 (1.5); 2.1947 (0.7); 2.1845 (1.6); 2.1798 (2.7); 2.1762 (2.7); 2.1682 (1.8); 2.1592 (1.8); 2.1551 (3.4); 2.1525 (3.5); 2.1484 (2.9); 2.1430 (2.5); 2.1378 (2.2); 2.1338 (2.8); 2.1279 (2.8); 2.1213 (2.8); 2.1133 (1.1); 2.1082 (1.0); 2.1012 (0.5); 2.0944 (0.9); 1.7356 (0.9); 1.7304 (0.6); 1.7283 (0.6); 1.7189 (2.7); 1.7108 (1.8); 1.7058 (2.4); 1.6949 (4.3); 1.6818 (2.6); 1.6709 (2.1); 1.6588 (0.7); 1.6555 (0.9); 1.5992 (2.3); 0.0080 (1.9); -0.0002 (66.4); -0.0085 (1.8) I.2-104: 1 H-NMR (400.0 MHz, CDCl3): δ= 8.5582 (3.9); 8.5558 (4.6); 8.5541 (4.7); 8.5518 (4.1); 8.5459 (4.0); 8.5436 (4.6); 8.5419 (4.6); 8.5395 (3.7); 7.7685 (13.5); 7.7659 (14.2); 7.7494 (4.3); 7.7468 (5.0); 7.7440 (4.1); 7.7413 (2.8); 7.7223 (3.4); 7.7178 (3.4); 7.7031 (6.4); 7.6986 (6.3); 7.6839 (4.0); 7.6794 (3.8); 7.5193 (1.1); 7.4795 (3.0); 7.4774 (2.8); 7.4603 (5.6); 7.4582 (5.2); 7.4389 (3.0); 7.3164 (5.6); 7.3140 (4.5); 7.3100 (2.8); 7.2997 (4.1); 7.2972 (5.0); 7.2822 (8.2); 7.2750 (2.8); 7.2742 (2.7); 7.2734 (2.7); 7.2726 (2.8); 7.2717 (2.9); 7.2709 (3.1); 7.2701 (3.4); 7.2693 (3.7); 7.2603 (198.0); 7.2473 (4.0); 7.2460 (3.9); 7.2445 (3.8); 7.2427 (3.3); 7.2408 (3.8); 7.2284 (3.2); 7.2271 (3.1); 7.1351 (2.5); 6.9964 (1.1); 6.7791 (4.7); 6.6381 (9.5); 6.4972 (4.7); 4.6184 (16.0); 4.6068 (15.6); 4.2425 (5.5); 4.2237 (6.1); 4.2184 (7.0); 4.1997 (7.0); 4.0522 (6.6); 4.0306 (8.3); 4.0283 (6.9); 4.0066 (5.3); 3.3739 (1.3); 3.3521 (3.4); 3.3311 (4.0); 3.3291 (3.9); 3.3101 (3.5); 3.2883 (1.3); 3.0601 (5.3); 3.0382 (4.4); 3.0174 (8.5); 2.9955 (7.7); 2.9052 (8.4); 2.8816 (7.7); 2.8625 (5.0); 2.8389 (4.5); 1.6390 (3.5); 1.2552 (1.1); 0.0080 (2.7); -0.0002 (75.0); -0.0085 (2.5) I.2-105: 1 H-NMR (400.0 MHz, CDCl 3 ): δ= 8.5575 (4.7); 8.5470 (4.7); 7.7314 (3.3); 7.7269 (3.4); 7.7122 (6.4); 7.7078 (6.2); 7.6930 (3.9); 7.6885 (3.7); 7.5243 (5.7); 7.5186 (14.3); 7.5141 (5.5); 7.4434 (3.8); 7.4410 (4.4); 7.4382 (3.5); 7.4357 (3.4); 7.4227 (6.3); 7.4202 (6.5); 7.4174 (6.1); 7.4150 (5.0); 7.3671 (7.5); 7.3466 (11.6); 7.3261 (5.3); 7.3101 (1.8); 7.2874 (8.2); 7.2596 (1068.7); 7.2370 (3.6); 7.2305 (0.8); 7.2104 (2.1); 7.1285 (2.5); 6.9956 (5.9); 6.9306 (4.2); 6.9270 (3.9); 6.9103 (3.6); 6.9067 (3.6); 6.7088 (7.9); 6.5241 (15.9); 6.3395 (8.1); 4.6208 (16.0); 4.6092 (15.4); 4.2037 (5.2); 4.1849 (6.2); 4.1796 (7.1); 4.1608 (6.9); 4.0204 (6.6); 3.9987 (8.4); 3.9964 (6.6); 3.9747 (5.4); 3.3616 (1.2); 3.3399 (3.3); 3.3195 (3.9); 3.2976 (3.5); 3.2756 (1.2); 3.0509 (5.3); 3.0289 (4.3); 3.0082 (8.4); 2.9862 (7.8); 2.8973 (8.6); 2.8738 (7.8); 2.8546 (5.1); 2.8310 (4.5); 2.0051 (1.1); 1.5720 (14.7); 1.2560 (0.7); 0.1459 (1.2); 0.0079 (19.2); -0.0002 (403.6); -0.0085 (13.2); - 0.0315 (0.7); -0.0495 (0.9); -0.1497 (1.2) I.2-106: 1 H-NMR (400.0 MHz, CDCl 3 ): δ= 8.7300 (15.7); 8.7178 (16.0); 7.5210 (0.7); 7.2621 (139.5); 7.2571 (6.4); 7.2446 (7.0); 7.2323 (3.4); 7.2120 (1.5); 6.9981 (0.8); 6.8853 (1.5); 4.7402 (5.4); 4.7354 (5.7); 4.7288 (5.7); 4.7243 (5.5); 4.5502 (0.6); 4.5298 (2.0); 4.5096 (2.8); 4.4893 (1.6); 3.7088 (2.6); 3.6908 (3.0); 3.6845 (3.9); 3.6665 (4.0); 3.5820 (3.8); 3.5603 (4.8); 3.5361 (3.0); 3.2347 (0.8); 3.2134 (1.9); 3.1953 (1.9); 3.1924 (2.4); 3.1894 (2.2); 3.1714 (2.0); 3.1501 (0.8); 2.8302 (2.6); 2.8092 (2.3); 2.7884 (5.4); 2.7675 (5.0); 2.7181 (5.6); 2.6940 (5.2); 2.6763 (2.8); 2.6522 (2.5); 1.8743 (1.5); 1.8632 (2.4); 1.8544 (2.0); 1.8476 (2.3); 1.8434 (2.5); 1.8322 (1.7); 1.8229 (1.2); 1.8181 (1.3); 1.7368 (0.5); 1.7019 (2.5); 1.6979 (2.8); 1.6907 (2.3); 1.6822 (2.5); 1.6601 (1.3); 1.6467 (1.5); 1.6217 (2.4); 1.6132 (2.4); 1.6043 (3.4); 1.5878 (8.1); 1.5665 (1.9); 1.5569 (1.6); 1.5493 (1.4); 1.5353 (1.4); 1.5159 (1.2); 1.5040 (1.1); 1.4855 (0.9); 1.2539 (0.5); 0.0080 (1.8); -0.0002 (60.9); -0.0085 (2.4); -0.0503 (0.7) I.2-107: 1 H-NMR (400.0 MHz, CDCl3): δ= 8.7301 (9.9); 8.7178 (10.1); 7.2646 (48.3); 7.2603 (0.7); 7.2589 (1.2); 7.2572 (2.3); 7.2555 (1.2); 7.2467 (2.1); 7.2449 (4.1); 7.2432 (2.1); 7.2344 (1.0); 7.2326 (2.0); 7.2309 (1.0); 6.8970 (0.7); 4.7389 (3.8); 4.7272 (3.7); 3.7498 (1.8); 3.7322 (1.9); 3.7253 (2.3); 3.7077 (2.5); 3.5807 (2.5); 3.5589 (3.0); 3.5563 (2.2); 3.5344 (2.1); 3.2486 (0.6); 3.2452 (0.9); 3.2422 (0.7); 3.2276 (0.9); 3.2242 (1.3); 3.2209 (1.0); 3.2034 (0.9); 3.1998 (0.7); 3.1821 (0.5); 3.1725 (0.8); 3.1530 (0.8); 3.1388 (2.2); 3.1193 (2.3); 3.1046 (2.1); 3.0863 (2.1); 3.0708 (0.8); 3.0525 (0.8); 2.8474 (1.1); 2.8269 (1.0); 2.8055 (2.2); 2.7849 (2.0); 2.7299 (2.1); 2.7057 (1.9); 2.6879 (1.0); 2.6637 (1.0); 1.9644 (0.5); 1.9461 (0.9); 1.9291 (1.2); 1.9123 (1.0); 1.8935 (0.5); 1.6429 (0.5); 0.9224 (15.4); 0.9205 (16.0); 0.9058 (15.1); 0.9038 (15.6); 0.0080 (0.6); 0.0024 (0.6); 0.0016 (0.9); -0.0002 (22.6); -0.0085 (0.6) I.2-108: 1 H-NMR (400.0 MHz, CDCl3): δ= 8.3161 (3.8); 8.3147 (3.9); 8.3099 (3.9); 8.3084 (3.8); 7.6341 (3.0); 7.6278 (2.9); 7.6136 (3.4); 7.6073 (3.4); 7.5199 (1.6); 7.3289 (5.0); 7.3275 (5.0); 7.3084 (4.4); 7.3069 (4.5); 7.2770 (0.6); 7.2722 (0.9); 7.2714 (1.0); 7.2706 (1.1); 7.2698 (1.2); 7.2674 (2.4); 7.2610 (301.4); 7.2569 (3.3); 7.2560 (2.3); 7.2552 (1.6); 7.2544 (1.2); 7.2536 (1.2); 7.2528 (1.1); 7.2520 (0.8); 7.2512 (0.7); 7.2504 (0.6); 7.2496 (0.6); 7.2488 (0.5); 7.2108 (2.0); 6.9970 (1.6); 5.9814 (1.1); 4.6512 (1.5); 4.6277 (2.2); 4.6074 (1.3); 4.5245 (1.0); 4.5095 (1.0); 4.4868 (3.5); 4.4716 (3.4); 4.4561 (3.4); 4.4412 (3.4); 4.4185 (1.1); 4.4035 (1.0); 3.7254 (1.9); 3.7071 (2.2); 3.7012 (3.9); 3.6829 (4.0); 3.6586 (4.0); 3.6371 (4.6); 3.6129 (2.2); 3.0840 (0.7); 3.0627 (1.7); 3.0444 (1.6); 3.0415 (2.1); 3.0386 (2.0); 3.0203 (1.8); 2.9990 (0.8); 2.7263 (2.1); 2.7052 (1.9); 2.6846 (5.2); 2.6634 (4.7); 2.6372 (5.4); 2.6131 (4.9); 2.5954 (2.2); 2.5713 (1.9); 2.2022 (0.9); 2.1782 (1.6); 2.1751 (2.0); 2.1516 (2.9); 2.1450 (3.6); 2.1409 (2.7); 2.1322 (2.6); 2.1236 (4.6); 2.1182 (3.2); 2.1119 (1.9); 2.1016 (2.0); 2.0967 (1.4); 1.7346 (0.9); 1.7273 (0.7); 1.7170 (2.5); 1.7105 (1.9); 1.7045 (2.1); 1.6937 (3.9); 1.6865 (1.3); 1.6809 (2.0); 1.6711 (1.8); 1.6551 (0.7); 1.5602 (16.0); 0.0080 (3.1); -0.0002 (129.7); -0.0085 (3.8); -0.0503 (0.8) I.2-109: 1 H-NMR (400.0 MHz, CDCl3): δ= 8.5468 (2.0); 8.5362 (2.0); 7.7159 (1.4); 7.7115 (1.4); 7.6967 (2.7); 7.6923 (2.6); 7.6775 (1.7); 7.6731 (1.6); 7.5201 (0.7); 7.2723 (4.1); 7.2612 (131.9); 7.2532 (6.0); 7.2407 (2.4); 7.2344 (2.1); 7.2220 (1.6); 7.2116 (1.3); 7.0094 (1.0); 6.9972 (1.4); 4.5887 (6.8); 4.5770 (6.8); 3.7073 (1.9); 3.6895 (2.1); 3.6829 (2.7); 3.6652 (2.7); 3.5596 (2.6); 3.5378 (3.5); 3.5134 (2.2); 3.2235 (0.6); 3.2020 (1.2); 3.1813 (1.5); 3.1602 (2.0); 3.1395 (1.4); 3.1257 (2.8); 3.1061 (3.0); 3.0978 (2.8); 3.0794 (2.8); 3.0639 (0.9); 3.0455 (0.9); 2.8121 (1.3); 2.7916 (1.2); 2.7703 (2.7); 2.7496 (2.5); 2.6966 (2.6); 2.6724 (2.4); 2.6546 (1.3); 2.6306 (1.2); 1.9527 (0.6); 1.9352 (1.2); 1.9182 (1.5); 1.9012 (1.3); 1.8826 (0.6); 1.6314 (4.6); 0.9173 (16.0); 0.9133 (15.9); 0.9006 (16.0); 0.8966 (15.6); 0.0080 (1.9); -0.0002 (56.1); -0.0085 (2.5) I.2-110: 1 H-NMR (400.0 MHz, CDCl3): δ= 7.2678 (0.6); 7.2670 (0.6); 7.2661 (0.8); 7.2654 (1.0); 7.2645 (1.3); 7.2606 (73.7); 7.2572 (1.1); 7.2564 (0.7); 7.2556 (0.5); 7.2107 (0.5); 1.5458 (16.0); 0.9110 (2.0); 0.9083 (2.0); 0.8944 (2.0); 0.8916 (2.0); 0.0080 (0.9); -0.0002 (32.0); -0.0085 (0.9) I.2-111: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.7254 (2.6); 8.7110 (4.2); 8.6958 (2.3); 8.3387 (8.7); 8.3340 (8.6); 8.3324 (8.3); 7.7694 (6.4); 7.7631 (6.2); 7.7489 (7.4); 7.7425 (7.5); 7.6543 (12.0); 7.6514 (14.6); 7.6463 (3.8); 7.6346 (7.8); 7.6322 (16.0); 7.6296 (13.6); 7.5008 (11.6); 7.4991 (11.4); 7.4802 (9.8); 7.4786 (9.8); 7.3892 (11.8); 7.3840 (3.4); 7.3707 (14.4); 7.3677 (11.1); 7.3538 (4.0); 7.3491 (11.8); 7.1560 (3.1); 7.1532 (6.3); 7.1505 (3.5); 7.1348 (9.5); 7.1163 (4.6); 5.7555 (2.4); 4.3406 (14.4); 4.3259 (14.4); 4.2282 (0.9); 4.0387 (5.2); 4.0172 (6.8); 4.0144 (8.2); 3.9929 (7.1); 3.9106 (7.2); 3.8952 (7.4); 3.8864 (5.1); 3.8709 (5.4); 3.8258 (0.9); 3.3684 (2.6); 3.3184 (1093.9); 3.2981 (4.9); 3.2918 (4.8); 3.2684 (9.8); 3.2564 (2.3); 3.2186 (1.4); 2.7862 (4.4); 2.7629 (4.0); 2.7439 (9.8); 2.7206 (8.9); 2.6909 (9.5); 2.6725 (11.0); 2.6653 (4.6); 2.6607 (2.2); 2.6486 (3.9); 2.6303 (3.6); 2.5553 (1.6); 2.5507 (2.4); 2.5460 (2.1); 2.5234 (13.8); 2.5187 (20.2); 2.5100 (314.0); 2.5054 (701.2); 2.5008 (993.8); 2.4962 (697.4); 2.4916 (311.3); 2.4601 (4.0); 2.4555 (6.5); 2.4510 (8.2); 2.4463 (6.6); 2.4003 (1.7); 2.3369 (2.3); 2.3323 (4.6); 2.3276 (6.2); 2.3230 (4.8); 2.0733 (3.1); 0.0080 (5.8); 0.0048 (1.6); 0.0039 (2.3); 0.0023 (7.1); -0.0002 (206.0); -0.0051 (4.0); -0.0085 (6.4); -0.0501 (1.4) I.2-112: 1 H-NMR (400.0 MHz, CDCl 3 ): δ= 8.5527 (3.8); 8.5503 (4.3); 8.5484 (4.4); 8.5460 (4.0); 8.5405 (4.0); 8.5380 (4.4); 8.5362 (4.4); 8.5337 (3.8); 7.7130 (4.1); 7.7085 (4.2); 7.6938 (7.2); 7.6893 (7.2); 7.6746 (5.0); 7.6701 (4.8); 7.5218 (1.3); 7.3128 (0.6); 7.2813 (0.6); 7.2789 (0.7); 7.2781 (0.8); 7.2749 (2.6); 7.2733 (4.7); 7.2709 (8.1); 7.2694 (7.1); 7.2685 (6.9); 7.2670 (5.8); 7.2662 (6.5); 7.2629 (224.8); 7.2596 (4.5); 7.2587 (2.8); 7.2579 (2.1); 7.2571 (2.0); 7.2562 (2.1); 7.2554 (2.8); 7.2538 (4.6); 7.2506 (8.6); 7.2490 (7.5); 7.2476 (5.4); 7.2436 (0.8); 7.2428 (0.7); 7.2420 (0.7); 7.2380 (4.1); 7.2365 (3.4); 7.2351 (3.5); 7.2332 (3.0); 7.2315 (3.7); 7.2301 (3.5); 7.2286 (3.4); 7.2191 (3.4); 7.2178 (3.0); 7.2164 (2.9); 7.2131 (2.2); 7.0325 (2.1); 6.9988 (1.5); 4.6903 (0.8); 4.6697 (2.4); 4.6469 (4.1); 4.6271 (2.3); 4.6032 (1.1); 4.5903 (16.0); 4.5786 (15.8); 3.7467 (3.0); 3.7279 (3.8); 3.7226 (8.0); 3.7038 (8.4); 3.6947 (8.4); 3.6731 (9.4); 3.6490 (3.7); 3.2058 (1.5); 3.1842 (3.4); 3.1653 (3.3); 3.1628 (4.1); 3.1603 (3.9); 3.1414 (3.5); 3.1388 (2.2); 3.1198 (1.5); 2.8058 (5.1); 2.7843 (4.4); 2.7639 (9.1); 2.7423 (8.5); 2.6764 (9.6); 2.6524 (9.2); 2.6345 (5.4); 2.6104 (4.8); 2.2205 (1.5); 2.2157 (2.1); 2.1951 (2.5); 2.1914 (4.8); 2.1881 (3.0); 2.1823 (1.0); 2.1669 (5.7); 2.1643 (4.8); 2.1594 (4.0); 2.1465 (4.8); 2.1428 (5.3); 2.1399 (7.4); 2.1347 (4.9); 2.1328 (5.0); 2.1295 (3.9); 2.1261 (5.0); 2.1169 (4.6); 2.1128 (4.5); 2.1046 (2.0); 2.1005 (1.6); 2.0925 (0.9); 2.0825 (0.5); 1.7288 (1.6); 1.7231 (1.2); 1.7210 (1.2); 1.7115 (5.1); 1.7040 (3.3); 1.6987 (4.6); 1.6878 (8.3); 1.6745 (6.3); 1.6624 (11.2); 1.2553 (0.7); 0.0081 (2.6); 0.0066 (0.6); 0.0057 (0.6); 0.0049 (0.7); 0.0041 (0.9); 0.0024 (2.7); -0.0002 (98.1); -0.0085 (2.8); -0.0501 (0.9) I.2-114: 1 H-NMR (400.0 MHz, CDCl3): δ= 8.1118 (7.1); 8.0987 (7.1); 7.5182 (3.7); 7.2812 (8.8); 7.2593 (663.2); 7.2388 (8.2); 7.2332 (6.7); 7.2143 (0.9); 7.2078 (0.5); 6.9954 (3.6); 6.8651 (4.9); 6.8617 (4.9); 6.8520 (4.7); 6.8485 (4.6); 6.7227 (8.5); 6.6448 (1.7); 6.6391 (2.7); 6.6337 (1.4); 6.6229 (3.2); 6.6172 (5.3); 6.6116 (2.8); 6.6009 (1.8); 6.5952 (2.7); 6.5895 (1.3); 6.0172 (2.0); 4.7945 (5.3); 4.7732 (15.7); 4.7517 (16.0); 4.7303 (5.4); 4.5379 (1.1); 4.5236 (1.2); 4.4989 (5.9); 4.4854 (8.8); 4.4716 (5.6); 4.4468 (0.9); 4.4312 (0.8); 4.3331 (7.5); 4.3088 (7.7); 3.5797 (8.6); 3.5554 (8.0); 3.1429 (7.0); 3.1011 (8.1); 2.5660 (9.3); 2.5243 (7.9); 2.0432 (1.7); 1.5597 (41.8); 1.5332 (141.7); 1.3830 (0.9); 1.3652 (0.8); 1.3326 (0.6); 1.2840 (0.9); 1.2584 (2.0); 1.2404 (0.6); 0.1459 (1.0); 0.0079 (11.3); -0.0002 (260.6); -0.0084 (9.5); -0.1495 (0.9) I.2-115: 1 H-NMR (400.0 MHz, CDCl3): δ= 8.4896 (2.3); 8.4769 (2.3); 7.2740 (1.7); 7.2683 (2.3); 7.2604 (37.2); 7.2506 (1.7); 7.2450 (1.4); 6.9965 (0.6); 6.9158 (1.7); 6.9031 (1.6); 6.6311 (0.5); 6.6149 (0.6); 6.6091 (1.1); 6.6034 (0.6); 6.5872 (0.5); 4.5301 (2.9); 4.5181 (2.9); 4.3199 (1.6); 4.2955 (1.6); 3.5827 (1.8); 3.5583 (1.7); 3.2043 (1.5); 3.1622 (1.7); 2.5869 (0.8); 2.5791 (16.0); 2.5363 (1.7); 2.0433 (1.6); 1.5856 (8.9); 1.2584 (1.0); 0.0078 (0.6); - 0.0002 (14.2); -0.0085 (0.5) I.2-118: 1 H-NMR (400.0 MHz, CDCl 3 ): δ= 8.1116 (3.6); 8.0984 (3.6); 7.5186 (0.8); 7.3120 (0.9); 7.2596 (147.8); 7.2389 (4.1); 7.2334 (3.3); 7.2220 (0.6); 6.9956 (0.8); 6.7489 (2.3); 6.7388 (2.2); 6.6414 (1.0); 6.6358 (1.6); 6.6301 (1.0); 6.6196 (1.8); 6.6138 (2.9); 6.6081 (1.8); 6.5983 (4.7); 6.5921 (1.8); 6.5863 (0.8); 6.0297 (1.0); 4.4910 (0.6); 4.4657 (3.3); 4.4601 (3.3); 4.4511 (3.2); 4.4455 (3.0); 4.3339 (3.7); 4.3095 (3.9); 4.2696 (4.9); 4.2528 (9.7); 4.2359 (4.8); 3.5731 (4.1); 3.5488 (3.9); 3.1496 (3.5); 3.1077 (3.9); 2.5571 (4.4); 2.5153 (3.8); 1.8367 (0.8); 1.8183 (2.4); 1.8011 (4.7); 1.7827 (4.7); 1.7655 (2.6); 1.7473 (0.8); 1.5503 (19.9); 1.2564 (0.6); 1.0376 (8.2); 1.0191 (16.0); 1.0005 (7.2); 0.0079 (2.8); -0.0002 (55.5); -0.0084 (2.3) I.2-119: 1 H-NMR (400.0 MHz, CDCl3): δ= 8.1648 (3.8); 8.1509 (3.9); 7.6467 (3.6); 7.5874 (15.6); 7.5829 (16.0); 7.5180 (4.8); 7.4644 (8.0); 7.2941 (1.2); 7.2822 (5.1); 7.2592 (882.8); 7.2262 (1.6); 7.2088 (2.0); 7.1671 (4.4); 7.1626 (7.9); 7.1581 (4.0); 6.9952 (5.0); 6.9907 (2.9); 6.9775 (2.6); 6.7587 (4.8); 6.7570 (4.8); 6.0514 (1.1); 4.5269 (2.8); 4.5119 (3.0); 4.5065 (3.0); 4.4913 (2.9); 4.4655 (0.8); 4.3364 (4.0); 4.3120 (4.1); 3.5856 (4.6); 3.5610 (4.3); 3.1272 (4.0); 3.0853 (4.6); 2.5661 (5.0); 2.5242 (4.3); 2.1356 (1.0); 2.1005 (1.0); 2.0431 (1.8); 1.5592 (21.7); 1.5308 (184.7); 1.2585 (2.0); 1.2406 (0.8); 0.1463 (1.1); 0.0080 (12.4); -0.0002 (339.5); - 0.0085 (10.8); -0.1493 (1.0) I.2-120: 1 H-NMR (400.6 MHz, CDCl3): δ= 8.4663 (4.9); 8.4538 (5.0); 7.5946 (12.2); 7.5901 (13.0); 7.5853 (0.8); 7.5199 (1.0); 7.2867 (0.6); 7.2822 (0.9); 7.2743 (1.4); 7.2614 (172.4); 7.1549 (3.4); 7.1505 (6.1); 7.1460 (2.9); 6.9978 (1.0); 6.9561 (0.9); 6.8842 (3.6); 6.8717 (3.5); 4.5259 (5.7); 4.5146 (5.6); 4.4708 (2.4); 4.4531 (7.7); 4.4354 (7.8); 4.4178 (2.4); 4.3269 (3.0); 4.3026 (3.2); 4.1308 (1.0); 4.1130 (1.0); 3.5827 (3.4); 3.5584 (3.3); 3.1913 (2.9); 3.1492 (3.3); 2.5751 (3.8); 2.5332 (3.4); 2.1346 (0.6); 2.1016 (2.0); 2.0454 (4.8); 1.5761 (19.3); 1.5688 (8.9); 1.5365 (1.2); 1.4766 (7.8); 1.4590 (16.0); 1.4413 (7.5); 1.3326 (1.4); 1.2843 (2.0); 1.2774 (1.8); 1.2595 (4.7); 1.2555 (3.5); 1.2417 (1.7); 0.8800 (0.7); 0.0079 (1.6); -0.0002 (49.6); -0.0085 (1.6) I.2-122: 1 H-NMR (400.0 MHz, CDCl 3 ): δ= 8.1342 (1.2); 8.1328 (1.2); 8.1210 (1.2); 8.1196 (1.2); 7.2712 (0.6); 7.2601 (62.9); 7.2559 (1.9); 7.2542 (2.0); 7.2502 (0.7); 7.2405 (0.6); 7.2362 (1.4); 7.2305 (1.2); 6.7608 (0.8); 6.7571 (0.9); 6.7475 (0.8); 6.7439 (0.9); 6.6368 (0.5); 6.6206 (0.6); 6.6148 (1.1); 6.6091 (0.6); 6.5959 (1.3); 6.5939 (1.8); 6.5924 (1.8); 6.5904 (1.2); 5.2983 (2.2); 4.4685 (1.0); 4.4556 (1.3); 4.4426 (1.0); 4.3290 (1.3); 4.3046 (1.4); 3.9331 (16.0); 3.5700 (1.5); 3.5456 (1.4); 3.1425 (1.3); 3.1006 (1.4); 2.5533 (1.6); 2.5115 (1.4); 1.5476 (11.0); 1.2837 (0.6); 1.2558 (2.0); 0.0080 (0.7); -0.0002 (22.7); -0.0084 (0.7) I.2-123: 1 H-NMR (400.0 MHz, CDCl 3 ): δ= 8.1381 (1.7); 8.1249 (1.8); 7.5877 (7.6); 7.5833 (7.7); 7.5184 (3.1); 7.2595 (579.1); 7.2272 (0.6); 7.1626 (1.9); 7.1580 (3.6); 7.1535 (1.8); 6.9955 (3.2); 6.7624 (1.1); 6.7497 (1.1); 6.5993 (2.0); 4.4706 (1.2); 4.4606 (1.5); 4.4459 (1.2); 4.3371 (1.7); 4.3128 (2.0); 3.9399 (16.0); 3.5735 (2.1); 3.5491 (2.0); 3.1354 (1.7); 3.0934 (2.0); 2.5497 (2.2); 2.5079 (2.0); 2.0434 (1.6); 1.5436 (16.9); 1.5361 (33.2); 1.2842 (0.7); 1.2763 (0.8); 1.2584 (2.4); 1.2390 (0.9); 0.1459 (0.7); 0.0080 (6.5); -0.0002 (218.1); -0.0085 (6.1); -0.1495 (0.7) I.2-124: 1 H-NMR (400.6 MHz, CDCl3): δ= 8.4657 (5.4); 8.4532 (5.6); 7.5202 (0.9); 7.2689 (5.3); 7.2617 (169.9); 7.2496 (1.5); 7.2455 (3.1); 7.2399 (2.8); 7.2302 (0.6); 6.9981 (1.3); 6.9824 (0.9); 6.8873 (3.6); 6.8748 (3.5); 6.6372 (0.7); 6.6315 (1.2); 6.6257 (0.6); 6.6153 (1.4); 6.6096 (2.3); 6.6039 (1.2); 6.5934 (0.7); 6.5877 (1.2); 6.5819 (0.5); 4.5265 (5.8); 4.5142 (5.7); 4.4689 (2.3); 4.4512 (7.2); 4.4335 (7.4); 4.4158 (2.3); 4.3212 (3.0); 4.2969 (3.2); 4.2719 (0.5); 4.2470 (0.6); 3.6256 (0.6); 3.6006 (0.6); 3.5822 (3.5); 3.5579 (3.3); 3.2100 (0.6); 3.2001 (3.0); 3.1667 (0.7); 3.1580 (3.3); 2.6000 (0.7); 2.5839 (3.8); 2.5568 (0.6); 2.5418 (3.3); 2.1347 (1.5); 2.1031 (2.4); 1.5803 (17.6); 1.5593 (4.3); 1.5418 (1.2); 1.4741 (8.0); 1.4564 (16.0); 1.4388 (8.0); 1.4252 (1.0); 1.3324 (0.6); 1.2843 (0.8); 1.2554 (1.1); 0.0080 (1.7); -0.0002 (49.8); -0.0084 (1.6) I.2-125: 1 H-NMR (400.0 MHz, CDCl3): δ= 8.1135 (2.5); 8.1121 (2.6); 8.1004 (2.5); 8.0989 (2.5); 7.5181 (1.7); 7.2921 (1.0); 7.2739 (1.3); 7.2592 (317.9); 7.2393 (2.8); 7.2337 (2.4); 6.9952 (1.7); 6.7391 (1.7); 6.7354 (1.8); 6.7259 (1.6); 6.7222 (1.7); 6.6422 (0.6); 6.6364 (1.1); 6.6306 (0.6); 6.6202 (1.2); 6.6145 (2.1); 6.6088 (1.1); 6.5982 (0.6); 6.5925 (1.1); 6.5869 (0.6); 6.5755 (2.3); 6.5736 (3.1); 6.5718 (3.0); 6.5700 (2.3); 5.9659 (0.6); 4.4614 (2.1); 4.4542 (2.1); 4.4466 (2.1); 4.4395 (2.0); 4.3823 (2.2); 4.3647 (7.0); 4.3470 (7.3); 4.3323 (2.8); 4.3294 (2.7); 4.3080 (2.7); 3.5699 (2.9); 3.5455 (2.8); 3.1470 (2.5); 3.1052 (2.9); 2.5534 (3.2); 2.5114 (2.8); 2.0985 (0.5); 1.5480 (14.6); 1.5347 (37.5); 1.4025 (7.5); 1.3848 (16.0); 1.3672 (7.2); 1.2565 (0.6); 0.0079 (3.9); 0.0063 (1.5); 0.0054 (1.6); -0.0002 (119.3); -0.0068 (1.4); -0.0085 (3.5) I.2-126: 1 H-NMR (400.0 MHz, CDCl3): δ= 8.1155 (2.4); 8.1008 (2.5); 7.5892 (10.6); 7.5847 (11.1); 7.5180 (2.7); 7.2591 (510.6); 7.2509 (1.8); 7.2500 (1.5); 7.2493 (1.3); 7.2484 (1.3); 7.2476 (1.2); 7.2452 (0.8); 7.2436 (0.7); 7.2413 (0.6); 7.2341 (0.5); 7.1616 (2.9); 7.1570 (5.6); 7.1525 (2.7); 6.9952 (2.7); 6.7395 (1.6); 6.7358 (1.7); 6.7264 (1.5); 6.7227 (1.6); 6.5764 (2.3); 6.5746 (2.8); 6.5727 (2.8); 5.9585 (0.6); 4.4603 (1.9); 4.4532 (2.1); 4.4456 (2.0); 4.4385 (2.0); 4.3838 (2.0); 4.3661 (6.7); 4.3485 (6.8); 4.3389 (2.4); 4.3308 (2.2); 4.3145 (2.6); 3.5719 (2.8); 3.5478 (2.7); 3.1392 (2.4); 3.0972 (2.7); 2.5465 (3.1); 2.5045 (2.7); 2.0994 (0.6); 2.0428 (1.5); 1.5434 (14.3); 1.5330 (64.8); 1.4036 (7.6); 1.3860 (16.0); 1.3682 (7.2); 1.2761 (0.5); 1.2583 (1.3); 0.1460 (0.6); 0.0079 (5.7); 0.0062 (2.2); -0.0002 (186.9); -0.0060 (1.8); -0.0069 (1.5); -0.0085 (5.1); - 0.1497 (0.5) I.2-127: 1 H-NMR (400.0 MHz, CDCl 3 ): δ= 8.2233 (0.8); 8.2116 (0.8); 7.5974 (10.3); 7.5929 (10.8); 7.5191 (0.8); 7.2602 (137.9); 7.2098 (0.5); 7.1978 (0.5); 7.1573 (2.7); 7.1528 (4.8); 7.1483 (2.5); 6.9962 (0.8); 6.4868 (2.8); 6.4741 (2.8); 4.4197 (1.9); 4.4096 (2.5); 4.4011 (1.5); 4.3308 (2.6); 4.3065 (2.7); 4.1306 (0.6); 4.1128 (0.6); 3.5894 (3.2); 3.5650 (3.0); 3.1986 (2.4); 3.1564 (2.7); 3.0250 (7.9); 3.0127 (7.8); 2.5806 (3.6); 2.5384 (3.1); 2.1307 (0.9); 2.0985 (16.0); 2.0437 (3.0); 1.5864 (0.9); 1.5739 (13.8); 1.5468 (1.4); 1.3323 (1.1); 1.2842 (1.6); 1.2763 (1.2); 1.2584 (4.2); 1.2406 (1.1); 0.8800 (0.6); 0.0080 (1.6); -0.0002 (53.6); -0.0085 (1.9) I.2-129: 1 H-NMR (400.0 MHz, CDCl3): δ= 8.1052 (1.3); 8.1038 (1.3); 8.0921 (1.3); 8.0906 (1.3); 7.5182 (0.6); 7.2749 (0.5); 7.2685 (0.8); 7.2594 (105.3); 7.2442 (0.6); 7.2399 (1.4); 7.2343 (1.2); 6.9954 (0.6); 6.7095 (0.9); 6.7058 (1.0); 6.6964 (0.9); 6.6926 (0.9); 6.6359 (0.6); 6.6196 (0.6); 6.6140 (1.1); 6.6083 (0.5); 6.5920 (0.6); 6.5303 (1.2); 6.5285 (1.6); 6.5266 (1.6); 6.5248 (1.2); 5.3181 (1.0); 5.3026 (1.4); 5.2871 (1.0); 4.4478 (1.2); 4.4435 (1.2); 4.4331 (1.2); 4.4307 (1.1); 4.4288 (1.2); 4.3331 (1.4); 4.3086 (1.5); 3.5694 (1.6); 3.5450 (1.5); 3.1490 (1.3); 3.1071 (1.5); 2.5512 (1.7); 2.5094 (1.5); 1.5470 (8.2); 1.5397 (15.6); 1.3445 (16.0); 1.3356 (0.9); 1.3290 (15.9); 0.0080 (1.2); 0.0055 (0.5); -0.0002 (38.2); -0.0085 (1.0) I.2-130: 1 H-NMR (400.0 MHz, CDCl3): δ= 8.2280 (0.9); 8.2149 (0.9); 7.5183 (1.4); 7.2834 (0.8); 7.2719 (3.8); 7.2661 (5.8); 7.2595 (247.0); 7.2536 (2.6); 7.2528 (2.6); 7.2503 (2.4); 7.2482 (3.6); 7.2426 (3.2); 7.2369 (0.8); 7.2313 (0.6); 7.2297 (0.5); 6.9955 (1.4); 6.6380 (0.7); 6.6323 (1.3); 6.6266 (0.6); 6.6160 (1.4); 6.6103 (2.5); 6.6046 (1.3); 6.5941 (0.8); 6.5884 (1.3); 6.5827 (0.6); 6.4843 (3.3); 6.4717 (3.3); 4.4205 (2.0); 4.4101 (2.6); 4.4021 (1.7); 4.3273 (3.0); 4.3030 (3.1); 4.1304 (0.6); 4.1126 (0.5); 3.5835 (3.7); 3.5592 (3.5); 3.2081 (2.7); 3.1660 (3.1); 3.0242 (11.6); 3.0116 (11.3); 2.5905 (0.7); 2.5855 (3.8); 2.5435 (3.3); 2.1938 (0.5); 2.1693 (0.5); 2.1312 (0.8); 2.0988 (16.0); 2.0430 (2.8); 1.5789 (15.9); 1.5531 (1.7); 1.3325 (1.2); 1.2842 (1.7); 1.2761 (1.0); 1.2582 (3.2); 1.2404 (0.9); 0.0079 (3.0); -0.0002 (99.8); -0.0060 (1.1); -0.0069 (0.9); -0.0085 (2.9) I.2-131: 1 H-NMR (400.0 MHz, CDCl 3 ): δ= 8.4817 (6.6); 8.4690 (6.8); 7.6056 (15.2); 7.6011 (16.0); 7.5186 (2.0); 7.3601 (0.8); 7.2918 (0.6); 7.2597 (357.0); 7.2547 (3.6); 7.2539 (2.5); 7.2531 (1.8); 7.2522 (1.5); 7.2514 (1.3); 7.2507 (1.1); 7.2498 (1.0); 7.2490 (0.8); 7.2483 (0.8); 7.2474 (0.7); 7.2467 (0.6); 7.1558 (4.0); 7.1513 (7.9); 7.1468 (3.9); 6.9957 (2.4); 6.9832 (0.9); 6.9065 (3.9); 6.8938 (3.9); 4.5245 (3.4); 4.5218 (3.4); 4.5124 (3.3); 4.5098 (3.4); 4.3262 (3.3); 4.3018 (3.5); 4.1304 (0.9); 4.1126 (1.0); 3.5856 (3.8); 3.5614 (3.7); 3.1984 (3.4); 3.1951 (3.2); 3.1766 (8.9); 3.1581 (10.7); 3.1398 (2.9); 2.5647 (4.2); 2.5226 (3.7); 2.0435 (4.6); 1.5788 (20.6); 1.4400 (9.8); 1.4216 (21.9); 1.4032 (9.6); 1.2765 (1.5); 1.2586 (3.3); 1.2407 (1.5); 0.0104 (0.6); 0.0095 (0.8); 0.0080 (4.2); 0.0065 (1.3); 0.0056 (1.4); 0.0048 (1.7); 0.0040 (2.3); 0.0031 (3.5); 0.0023 (5.6); -0.0002 (129.2); -0.0050 (1.9); -0.0058 (1.4); -0.0067 (1.2); -0.0085 (3.6); -0.0114 (0.6) I.2-132: 1 H-NMR (400.0 MHz, CDCl 3 ): δ= 8.1258 (1.5); 8.1242 (1.5); 8.1130 (1.5); 8.1113 (1.6); 7.5869 (6.8); 7.5824 (7.0); 7.5184 (0.7); 7.2596 (129.4); 7.1584 (1.7); 7.1539 (3.3); 7.1494 (1.6); 6.9956 (0.7); 6.3929 (1.0); 6.3895 (1.2); 6.3800 (1.0); 6.3766 (1.1); 6.3315 (1.9); 6.3301 (1.9); 4.4007 (1.3); 4.3880 (1.7); 4.3754 (1.3); 4.3400 (1.8); 4.3158 (1.8); 3.6067 (0.9); 3.5890 (3.0); 3.5713 (3.2); 3.5653 (2.2); 3.5536 (1.0); 3.5409 (1.9); 3.1334 (1.7); 3.0914 (1.9); 3.0211 (16.0); 2.5352 (2.2); 2.4933 (1.9); 2.0767 (2.2); 2.0429 (1.6); 1.5276 (9.1); 1.2761 (0.6); 1.2582 (1.4); 1.2404 (0.5); 1.1661 (3.8); 1.1484 (8.6); 1.1307 (3.8); 0.0079 (1.4); -0.0002 (52.0); - 0.0085 (1.6) I.2-133: 1 H-NMR (400.0 MHz, CDCl3): δ= 8.6204 (0.8); 8.6028 (15.9); 8.5901 (16.0); 7.5183 (7.1); 7.3601 (0.7); 7.3490 (0.7); 7.3220 (0.8); 7.3099 (2.5); 7.2909 (2.6); 7.2835 (3.4); 7.2721 (13.9); 7.2706 (12.4); 7.2659 (22.0); 7.2595 (1275.4); 7.2529 (11.4); 7.2512 (7.4); 7.2504 (7.7); 7.2487 (10.6); 7.2438 (15.8); 7.2369 (2.3); 7.2312 (11.2); 7.2249 (1.0); 7.2099 (1.7); 7.1598 (0.8); 6.9955 (6.9); 6.7503 (2.1); 6.6405 (1.8); 6.6348 (3.4); 6.6292 (1.8); 6.6186 (3.9); 6.6129 (6.9); 6.6072 (3.3); 6.5967 (2.1); 6.5910 (3.5); 6.5854 (1.6); 4.6415 (0.6); 4.5978 (9.4); 4.5950 (9.3); 4.5846 (9.0); 4.5818 (9.4); 4.3146 (8.9); 4.2901 (9.5); 4.1483 (0.7); 4.1304 (2.0); 4.1126 (1.8); 4.0949 (0.7); 3.5939 (10.4); 3.5695 (9.6); 3.1930 (8.6); 3.1508 (9.9); 2.5982 (11.2); 2.5561 (9.8); 2.1356 (0.6); 2.0434 (9.2); 1.5942 (48.4); 1.5343 (315.3); 1.4194 (1.4); 1.4020 (1.3); 1.3327 (1.2); 1.2842 (1.7); 1.2764 (3.0); 1.2585 (6.7); 1.2407 (2.7); 0.1460 (1.5); 0.0503 (0.9); 0.0080 (15.8); -0.0002 (525.0); -0.0085 (15.0); -0.0498 (0.8); -0.1496 (1.6) I.2-136: 1 H-NMR (400.0 MHz, CDCl3): δ= 8.0843 (12.6); 8.0712 (12.8); 7.5183 (4.9); 7.2946 (1.1); 7.2869 (1.9); 7.2751 (4.8); 7.2594 (869.3); 7.2445 (6.4); 7.2404 (13.8); 7.2347 (11.6); 7.2289 (2.6); 7.2261 (2.9); 7.2233 (1.7); 7.2159 (1.2); 6.9954 (4.7); 6.6872 (8.2); 6.6834 (8.5); 6.6741 (8.1); 6.6703 (8.2); 6.6406 (2.7); 6.6349 (5.1); 6.6292 (2.5); 6.6187 (5.5); 6.6130 (9.9); 6.6073 (4.9); 6.5967 (3.1); 6.5910 (5.0); 6.5854 (2.4); 6.5019 (11.7); 6.5001 (14.8); 6.4983 (14.4); 5.9232 (3.1); 4.4479 (0.9); 4.4235 (11.5); 4.4190 (11.5); 4.4088 (11.4); 4.4044 (11.2); 4.3800 (0.7); 4.3656 (0.7); 4.3322 (12.8); 4.3078 (13.5); 3.5657 (14.6); 3.5413 (13.8); 3.1488 (12.3); 3.1070 (13.9); 2.5450 (16.0); 2.5031 (14.1); 2.0041 (0.7); 1.7324 (1.1); 1.5918 (3.8); 1.5765 (394.5); 1.5533 (12.8); 1.5410 (74.1); 1.5360 (212.7); 1.4173 (1.8); 1.3727 (0.9); 1.3552 (0.8); 1.2839 (1.6); 1.2632 (3.4); 0.8987 (1.7); 0.8819 (5.1); 0.8644 (2.1); 0.1457 (1.1); 0.0080 (11.2); -0.0002 (335.7); -0.0085 (9.8); -0.0335 (0.7); -0.1496 (1.0) I.2-137: 1 H-NMR (400.0 MHz, CDCl 3 ): δ= 8.1245 (1.7); 8.1230 (1.6); 8.1117 (1.7); 8.1101 (1.6); 7.5185 (0.6); 7.2797 (0.6); 7.2724 (1.1); 7.2596 (116.4); 7.2514 (1.2); 7.2413 (0.8); 7.2373 (1.8); 7.2316 (1.6); 6.9956 (0.6); 6.6336 (0.7); 6.6174 (0.8); 6.6117 (1.4); 6.6060 (0.7); 6.5898 (0.7); 6.3935 (1.1); 6.3902 (1.2); 6.3806 (1.0); 6.3773 (1.1); 6.3330 (2.1); 4.4026 (1.4); 4.3899 (1.8); 4.3771 (1.3); 4.3356 (1.8); 4.3112 (1.9); 3.6070 (1.0); 3.5893 (3.1); 3.5716 (3.2); 3.5621 (2.2); 3.5539 (1.1); 3.5377 (1.9); 3.1412 (1.7); 3.0993 (2.0); 3.0351 (0.7); 3.0212 (16.0); 2.5413 (2.2); 2.4994 (1.9); 1.5519 (1.7); 1.5324 (10.1); 1.1657 (4.0); 1.1571 (0.6); 1.1480 (8.6); 1.1303 (3.8); 0.0080 (1.6); -0.0002 (45.7); -0.0085 (1.3) I.2-138: 1 H-NMR (400.0 MHz, CDCl3): δ= 8.1708 (6.2); 8.1693 (6.1); 8.1581 (6.3); 8.1565 (6.1); 7.5183 (3.8); 7.2985 (0.7); 7.2929 (1.3); 7.2794 (2.0); 7.2770 (2.9); 7.2755 (2.9); 7.2738 (3.4); 7.2722 (4.2); 7.2714 (4.7); 7.2691 (6.7); 7.2682 (7.0); 7.2674 (7.9); 7.2666 (8.9); 7.2594 (661.2); 7.2544 (9.0); 7.2536 (8.3); 7.2527 (9.4); 7.2505 (5.3); 7.2497 (4.0); 7.2488 (3.6); 7.2481 (3.5); 7.2465 (2.0); 7.2457 (1.5); 7.2449 (1.2); 7.2441 (1.3); 7.2433 (1.2); 7.2425 (1.1); 7.2409 (1.4); 7.2385 (2.9); 7.2345 (7.2); 7.2289 (6.2); 7.2233 (1.0); 7.2171 (1.0); 7.2098 (0.9); 6.9954 (3.6); 6.6436 (1.6); 6.6380 (2.8); 6.6322 (1.5); 6.6218 (3.1); 6.6160 (5.4); 6.6104 (2.6); 6.5998 (1.7); 6.5942 (2.7); 6.5884 (1.4); 6.5401 (4.1); 6.5368 (4.5); 6.5241 (4.5); 6.4974 (7.5); 5.9398 (1.6); 4.4177 (8.5); 4.4031 (8.2); 4.3318 (6.8); 4.3073 (7.1); 4.1479 (1.0); 4.1301 (2.8); 4.1122 (2.9); 4.0943 (1.0); 3.8264 (14.2); 3.8144 (16.0); 3.8018 (15.9); 3.5662 (7.9); 3.5418 (7.4); 3.5105 (15.9); 3.4978 (15.2); 3.4858 (13.0); 3.1259 (6.6); 3.0841 (7.5); 2.5532 (8.5); 2.5114 (7.3); 2.0861 (2.3); 2.0429 (13.5); 1.5573 (4.9); 1.5346 (38.4); 1.4291 (0.6); 1.4125 (0.6); 1.3492 (0.5); 1.3328 (0.6); 1.2839 (1.1); 1.2762 (4.2); 1.2584 (9.8); 1.2405 (4.1); 0.8804 (0.7); 0.1458 (0.7); 0.0079 (8.6); 0.0062 (4.0); -0.0002 (257.6); -0.0052 (3.1); -0.0060 (2.4); -0.0069 (2.3); -0.0085 (7.4); -0.0124 (0.8); -0.1496 (0.7) I.2-139: 1 H-NMR (400.0 MHz, CDCl3): δ= 8.0854 (3.9); 8.0842 (3.9); 8.0724 (4.0); 8.0711 (4.0); 7.5897 (15.8); 7.5852 (16.0); 7.5183 (1.1); 7.2594 (195.3); 7.2496 (0.7); 7.2480 (0.5); 7.1593 (4.0); 7.1548 (7.4); 7.1502 (3.8); 6.9954 (1.1); 6.6871 (2.6); 6.6833 (2.7); 6.6741 (2.5); 6.6703 (2.6); 6.5021 (3.5); 6.5004 (4.6); 6.4985 (4.5); 6.4968 (3.5); 5.9252 (1.0); 4.4214 (3.4); 4.4165 (3.5); 4.4069 (3.4); 4.4020 (3.4); 4.3377 (4.0); 4.3133 (4.2); 4.1295 (0.6); 4.1117 (0.6); 3.5673 (4.6); 3.5429 (4.3); 3.1401 (3.9); 3.0982 (4.4); 2.5367 (5.0); 2.4948 (4.4); 2.0964 (0.7); 2.0424 (2.7); 1.5916 (0.8); 1.5768 (130.4); 1.5534 (0.9); 1.5361 (26.4); 1.3042 (1.1); 1.2841 (1.5); 1.2758 (2.8); 1.2649 (5.4); 1.2582 (4.2); 1.2402 (1.2); 0.8989 (2.9); 0.8819 (10.6); 0.8642 (3.9); 0.0692 (0.5); 0.0080 (2.2); -0.0002 (80.5); -0.0085 (2.4) I.2-140: 1 H-NMR (400.0 MHz, CDCl 3 ): δ= 8.4522 (12.8); 8.4397 (13.0); 7.5198 (1.0); 7.2872 (1.2); 7.2797 (2.0); 7.2679 (10.7); 7.2609 (179.8); 7.2446 (8.3); 7.2391 (6.9); 7.2335 (1.4); 7.2274 (1.2); 7.2202 (0.5); 6.9968 (1.2); 6.9322 (2.5); 6.8524 (9.4); 6.8399 (9.1); 6.6350 (1.6); 6.6293 (2.9); 6.6236 (1.6); 6.6131 (3.3); 6.6073 (5.7); 6.6017 (2.9); 6.5911 (1.8); 6.5854 (2.9); 6.5797 (1.4); 5.3166 (1.9); 5.3009 (5.4); 5.2987 (4.8); 5.2855 (6.6); 5.2700 (4.9); 5.2545 (2.0); 4.5147 (16.0); 4.5026 (15.8); 4.3190 (8.1); 4.2947 (8.6); 3.5772 (9.3); 3.5529 (8.8); 3.1987 (7.9); 3.1565 (8.9); 2.5752 (10.1); 2.5497 (1.0); 2.5332 (8.9); 2.2833 (0.6); 2.1941 (0.8); 2.1295 (3.7); 2.0988 (0.9); 1.5769 (46.6); 1.4381 (2.8); 1.4262 (39.2); 1.4108 (38.7); 1.3328 (1.9); 1.2842 (2.7); 1.2568 (5.4); 0.8966 (0.7); 0.8803 (1.8); 0.8628 (0.9); 0.0079 (2.2); -0.0002 (64.4); -0.0084 (2.5) I.2-141: 1 H-NMR (400.0 MHz, CDCl3): δ= 8.1581 (7.2); 8.1451 (7.3); 7.6430 (7.5); 7.5192 (1.0); 7.4607 (16.0); 7.2784 (8.4); 7.2734 (1.7); 7.2604 (179.0); 7.2545 (7.7); 7.2489 (7.7); 7.2449 (2.8); 7.2352 (3.1); 7.2310 (7.6); 7.2254 (6.4); 7.2196 (1.1); 7.2138 (1.0); 6.9963 (1.2); 6.9888 (5.1); 6.9869 (4.3); 6.9851 (5.1); 6.9757 (4.8); 6.9739 (4.1); 6.9721 (4.9); 6.7545 (7.1); 6.7527 (8.9); 6.7510 (8.7); 6.7492 (6.5); 6.6465 (1.8); 6.6408 (3.2); 6.6351 (1.6); 6.6246 (3.6); 6.6189 (6.3); 6.6132 (3.1); 6.6027 (1.9); 6.5970 (3.1); 6.5913 (1.5); 6.1294 (1.7); 4.5629 (1.1); 4.5477 (1.2); 4.5232 (5.4); 4.5079 (5.9); 4.5057 (5.6); 4.5036 (5.8); 4.4884 (5.3); 4.4637 (1.2); 4.4488 (1.1); 4.3260 (7.7); 4.3015 (8.2); 4.1279 (0.7); 4.1101 (0.7); 3.5829 (9.0); 3.5585 (8.5); 3.1317 (7.5); 3.0898 (8.6); 2.5680 (9.8); 2.5262 (8.4); 2.1312 (0.7); 2.0420 (3.4); 1.5614 (42.6); 1.5545 (28.0); 1.2817 (0.7); 1.2756 (1.2); 1.2577 (3.0); 1.2399 (1.1); 0.0079 (2.3); -0.0002 (67.0); -0.0085 (1.9) I.2-142: 1 H-NMR (400.0 MHz, CDCl3): δ= 8.3342 (2.9); 8.3215 (2.9); 7.4361 (1.8); 7.4323 (3.2); 7.4276 (1.9); 7.2872 (2.9); 7.2628 (37.6); 7.1940 (3.5); 7.1924 (3.5); 7.1048 (2.0); 7.1031 (1.8); 7.1012 (1.9); 7.0920 (1.9); 7.0885 (1.8); 6.9815 (3.0); 6.3794 (0.8); 4.4895 (2.2); 4.4756 (3.7); 4.4614 (2.1); 4.3291 (3.1); 4.3044 (3.3); 4.1440 (0.9); 4.1262 (2.6); 4.1083 (2.7); 4.0904 (0.9); 3.5933 (3.6); 3.5686 (3.4); 3.0964 (2.9); 3.0547 (3.3); 2.9516 (0.9); 2.8673 (0.8); 2.5411 (3.7); 2.4994 (3.2); 2.3330 (16.0); 2.3320 (15.8); 2.0412 (12.3); 1.5458 (16.6); 1.2815 (0.5); 1.2752 (3.6); 1.2573 (8.0); 1.2395 (3.5); -0.0002 (13.4) I.2-143: 1 H-NMR (400.0 MHz, CDCl3): δ= 8.4912 (2.5); 8.4784 (2.5); 7.6050 (5.7); 7.6004 (5.8); 7.5185 (0.8); 7.2597 (139.2); 7.2474 (0.6); 7.2096 (0.6); 7.1563 (1.4); 7.1517 (2.7); 7.1473 (1.4); 6.9957 (1.0); 6.9162 (1.7); 6.9034 (1.7); 4.5299 (2.0); 4.5176 (2.0); 4.3262 (1.5); 4.3019 (1.6); 4.1305 (0.8); 4.1126 (0.8); 3.5883 (1.8); 3.5640 (1.6); 3.1986 (1.5); 3.1565 (1.7); 2.5810 (16.0); 2.5707 (2.0); 2.5286 (1.7); 2.0435 (3.8); 1.5815 (8.6); 1.5563 (2.2); 1.2765 (1.1); 1.2586 (2.4); 1.2407 (1.1); 0.0080 (1.8); -0.0002 (55.4); -0.0085 (1.8) I.2-144: 1 H-NMR (400.0 MHz, CDCl 3 ): δ= 8.3258 (11.8); 8.3130 (12.0); 7.5643 (10.6); 7.5613 (14.0); 7.5565 (4.0); 7.5422 (16.0); 7.5401 (14.8); 7.5343 (1.8); 7.5214 (0.9); 7.3967 (2.1); 7.3919 (12.9); 7.3866 (4.1); 7.3785 (2.8); 7.3732 (17.0); 7.3709 (13.0); 7.3654 (2.1); 7.3564 (4.6); 7.3517 (12.6); 7.3463 (1.5); 7.2746 (0.5); 7.2738 (0.5); 7.2731 (0.6); 7.2723 (0.6); 7.2698 (1.1); 7.2624 (148.7); 7.2008 (4.9); 7.1979 (12.6); 7.1949 (16.5); 7.1927 (14.2); 7.1831 (4.3); 7.1795 (11.4); 7.1758 (3.8); 7.1637 (3.0); 7.1609 (5.3); 7.1581 (2.7); 7.1004 (7.8); 7.0986 (6.8); 7.0968 (7.4); 7.0876 (7.6); 7.0859 (6.5); 7.0840 (7.1); 6.9984 (0.9); 6.4489 (2.5); 5.2977 (3.6); 4.5194 (1.5); 4.5041 (1.5); 4.4797 (8.0); 4.4639 (14.8); 4.4483 (7.9); 4.4235 (1.5); 4.4087 (1.4); 4.3672 (12.7); 4.3423 (13.5); 3.6248 (15.0); 3.6000 (14.1); 3.0962 (11.7); 3.0546 (13.4); 2.5431 (14.9); 2.5016 (13.0); 2.3141 (0.7); 2.3059 (0.6); 2.2632 (1.5); 2.0409 (1.3); 1.6433 (10.2); 1.5486 (66.9); 1.3286 (1.1); 1.2812 (1.7); 1.2747 (0.6); 1.2569 (3.7); 1.2390 (0.5); 0.8799 (0.7); 0.0079 (1.6); 0.0063 (0.6); -0.0002 (53.1); -0.0085 (1.5) I.2-145: 1 H-NMR (400.0 MHz, CDCl3): δ= 8.1134 (3.0); 8.1119 (3.0); 8.1002 (3.0); 8.0988 (3.1); 7.5874 (12.6); 7.5829 (13.0); 7.5189 (0.8); 7.2601 (135.1); 7.1607 (3.2); 7.1561 (5.9); 7.1516 (3.0); 6.9961 (0.8); 6.7371 (2.1); 6.7333 (2.2); 6.7239 (2.0); 6.7201 (2.1); 6.5877 (2.9); 6.5860 (3.7); 6.5841 (3.6); 6.5823 (2.8); 5.9868 (0.8); 4.4587 (2.5); 4.4513 (2.6); 4.4440 (2.5); 4.4366 (2.5); 4.3387 (3.1); 4.3143 (3.3); 4.2620 (4.9); 4.2451 (10.4); 4.2282 (5.0); 3.5727 (3.6); 3.5484 (3.4); 3.1391 (3.1); 3.0972 (3.5); 2.5458 (4.0); 2.5039 (3.5); 2.1316 (0.9); 2.0955 (2.2); 2.0426 (2.2); 1.8337 (0.6); 1.8151 (2.1); 1.7981 (4.2); 1.7796 (4.4); 1.7625 (2.2); 1.7442 (0.6); 1.5432 (19.7); 1.4236 (0.5); 1.2760 (0.8); 1.2581 (2.1); 1.2402 (0.7); 1.0364 (7.8); 1.0179 (16.0); 0.9993 (7.0); 0.0080 (1.6); 0.0065 (0.6); 0.0055 (0.6); -0.0002 (50.7); -0.0066 (0.7); -0.0085 (1.5) I.2-146: 1 H-NMR (400.0 MHz, CDCl3): δ= 8.0981 (3.9); 8.0968 (3.8); 8.0849 (3.9); 8.0836 (3.9); 7.5884 (15.6); 7.5838 (16.0); 7.5188 (1.1); 7.2599 (197.9); 7.1615 (4.0); 7.1570 (7.5); 7.1525 (3.8); 6.9959 (1.1); 6.7299 (2.6); 6.7262 (2.7); 6.7167 (2.5); 6.7130 (2.6); 6.5474 (3.6); 6.5457 (4.6); 6.5438 (4.5); 6.5421 (3.4); 5.9735 (1.0); 5.1931 (1.7); 5.1910 (1.1); 5.1757 (2.3); 5.1735 (2.3); 5.1582 (1.1); 5.1561 (1.7); 5.1539 (1.1); 4.4514 (3.2); 4.4444 (3.3); 4.4366 (3.2); 4.4296 (3.1); 4.3370 (4.0); 4.3126 (4.2); 4.1295 (0.7); 4.1117 (0.7); 3.5710 (4.6); 3.5467 (4.3); 3.1375 (3.9); 3.0956 (4.4); 2.5438 (5.0); 2.5019 (4.4); 2.4878 (0.9); 2.4811 (1.2); 2.4740 (0.9); 2.4703 (1.1); 2.4677 (1.3); 2.4638 (1.9); 2.4608 (1.7); 2.4572 (2.0); 2.4504 (2.0); 2.4436 (2.1); 2.4399 (1.8); 2.4370 (2.2); 2.4331 (1.4); 2.4306 (1.3); 2.4267 (1.0); 2.4195 (1.4); 2.4131 (1.0); 2.1731 (0.5); 2.1522 (1.0); 2.1475 (2.1); 2.1406 (1.4); 2.1325 (1.0); 2.1281 (2.1); 2.1234 (2.1); 2.1214 (2.1); 2.1167 (1.8); 2.1040 (1.5); 2.0968 (2.4); 2.0926 (1.0); 2.0794 (0.6); 2.0732 (0.6); 2.0427 (3.4); 1.8492 (0.9); 1.8460 (1.3); 1.8434 (1.0); 1.8393 (0.6); 1.8265 (0.7); 1.8242 (0.8); 1.8214 (1.3); 1.8188 (1.1); 1.7299 (0.5); 1.7097 (1.0); 1.7037 (0.8); 1.6894 (0.6); 1.6842 (1.9); 1.6790 (0.8); 1.6633 (0.8); 1.6588 (1.1); 1.6568 (1.5); 1.6370 (0.6); 1.6314 (0.7); 1.5420 (30.2); 1.2839 (0.5); 1.2760 (1.1); 1.2582 (2.8); 1.2403 (1.0); 0.0080 (2.6); -0.0002 (78.9); -0.0085 (2.4) I.2-147: 1 H-NMR (400.0 MHz, CDCl 3 ): δ= 8.4829 (10.6); 8.4702 (10.8); 7.5184 (4.5); 7.3099 (1.8); 7.2961 (1.2); 7.2767 (7.4); 7.2709 (10.2); 7.2596 (841.7); 7.2536 (10.2); 7.2489 (4.4); 7.2473 (6.3); 7.2417 (1.4); 7.2361 (0.9); 7.2282 (0.7); 7.2257 (0.8); 6.9956 (5.9); 6.9087 (6.6); 6.8959 (6.4); 6.6365 (1.5); 6.6309 (2.5); 6.6252 (1.3); 6.6147 (3.0); 6.6090 (5.0); 6.6032 (2.5); 6.5927 (1.4); 6.5870 (2.6); 6.5813 (1.2); 4.5256 (8.0); 4.5136 (8.0); 4.3192 (5.8); 4.2948 (6.3); 3.5805 (7.0); 3.5561 (6.4); 3.2054 (5.9); 3.1957 (4.8); 3.1772 (15.2); 3.1633 (7.2); 3.1588 (16.0); 3.1405 (4.9); 2.5717 (7.3); 2.5297 (6.5); 2.1011 (0.6); 2.0435 (1.0); 1.5835 (34.8); 1.5642 (10.6); 1.4396 (16.9); 1.4212 (35.9); 1.4028 (16.3); 1.3332 (0.6); 1.2843 (0.9); 1.2767 (0.8); 1.2585 (1.5); 0.1458 (0.9); 0.0079 (9.8); 0.0063 (3.7); 0.0054 (4.1); -0.0002 (313.2); -0.0060 (3.1); -0.0068 (2.5); - 0.0085 (8.9); -0.1496 (0.9) I.2-148: 1 H-NMR (400.0 MHz, CDCl3): δ= 8.1075 (1.3); 8.0944 (1.4); 7.5901 (6.2); 7.5856 (6.3); 7.5185 (0.7); 7.2596 (122.2); 7.2537 (0.8); 7.2529 (0.6); 7.1611 (1.5); 7.1566 (2.9); 7.1521 (1.4); 6.9956 (0.7); 6.7117 (0.9); 6.7081 (0.9); 6.6985 (0.8); 6.6949 (0.8); 6.5313 (1.6); 6.5295 (1.5); 5.3196 (1.0); 5.3041 (1.3); 5.2887 (1.0); 4.4476 (1.1); 4.4429 (1.1); 4.4331 (1.1); 4.4283 (1.1); 4.3398 (1.4); 4.3154 (1.5); 3.5717 (1.6); 3.5474 (1.5); 3.1417 (1.3); 3.0998 (1.5); 2.5446 (1.7); 2.5027 (1.5); 2.0427 (1.8); 1.5426 (14.6); 1.3463 (16.0); 1.3308 (15.9); 1.2760 (0.6); 1.2581 (1.4); 1.2403 (0.5); 0.0079 (1.4); 0.0054 (0.5); 0.0046 (0.6); -0.0002 (45.4); -0.0027 (2.4); -0.0052 (0.6); -0.0085 (1.3) I.2-149: 1 H-NMR (400.0 MHz, CDCl3): δ= 8.4536 (7.5); 8.4411 (7.6); 7.5944 (15.8); 7.5899 (16.0); 7.5186 (1.6); 7.2930 (0.9); 7.2597 (286.6); 7.1540 (4.1); 7.1495 (7.6); 7.1450 (3.9); 6.9957 (1.9); 6.9158 (1.5); 6.8519 (5.4); 6.8395 (5.3); 5.3165 (1.1); 5.3010 (2.8); 5.2855 (3.9); 5.2700 (2.9); 5.2544 (1.1); 4.5137 (9.4); 4.5016 (9.1); 4.3235 (4.7); 4.2993 (4.9); 4.1303 (0.6); 4.1123 (0.6); 3.5778 (5.3); 3.5535 (5.0); 3.1889 (4.6); 3.1467 (5.1); 2.5679 (5.9); 2.5494 (0.6); 2.5258 (5.1); 2.2832 (0.9); 2.2604 (0.5); 2.1940 (0.9); 2.1336 (2.7); 2.1008 (1.2); 2.0432 (2.8); 1.5720 (25.5); 1.5434 (11.9); 1.4392 (2.0); 1.4283 (25.1); 1.4128 (24.7); 1.3328 (1.0); 1.2841 (1.8); 1.2763 (1.6); 1.2586 (6.9); 1.2407 (1.3); 0.8970 (1.0); 0.8804 (2.5); 0.8628 (1.2); 0.8311 (0.7); 0.0080 (3.7); -0.0002 (112.2); -0.0085 (3.6) I.2-150: 1 H-NMR (400.0 MHz, CDCl 3 ): δ= 8.1318 (12.7); 8.1185 (12.7); 7.5181 (9.6); 7.2592 (1670.0); 7.2417 (16.3); 7.2361 (11.8); 7.2095 (2.1); 7.0964 (84.4); 7.0810 (51.0); 6.9952 (9.4); 6.8758 (8.9); 6.8592 (8.0); 6.7618 (14.9); 6.6444 (3.0); 6.6388 (4.7); 6.6228 (5.4); 6.6169 (8.9); 6.6116 (4.7); 6.5952 (4.8); 6.0423 (3.6); 4.5259 (9.9); 4.5124 (16.0); 4.4978 (9.0); 4.3344 (12.5); 4.3098 (13.0); 4.1306 (3.6); 4.1125 (3.3); 3.5821 (14.4); 3.5577 (12.9); 3.1378 (11.9); 3.0961 (13.4); 2.5712 (15.4); 2.5296 (13.1); 2.0433 (15.1); 2.0043 (2.0); 1.5579 (71.3); 1.5323 (327.0); 1.3330 (2.1); 1.2763 (4.7); 1.2585 (10.4); 1.2408 (4.2); 0.1463 (2.7); 0.0080 (31.6); -0.0002 (649.8); -0.0085 (27.5); -0.1497 (3.0) I.2-151: 1 H-NMR (400.0 MHz, CDCl 3 ): δ= 8.1343 (3.4); 8.1212 (3.4); 7.5906 (15.5); 7.5861 (16.0); 7.5181 (3.7); 7.3496 (1.1); 7.3106 (0.8); 7.2938 (1.2); 7.2903 (0.7); 7.2871 (0.9); 7.2752 (1.9); 7.2744 (1.9); 7.2736 (2.1); 7.2728 (2.2); 7.2704 (3.0); 7.2687 (4.2); 7.2680 (4.7); 7.2672 (5.2); 7.2593 (645.7); 7.2527 (4.4); 7.2519 (3.3); 7.2510 (2.4); 7.2502 (1.9); 7.2494 (1.7); 7.2486 (1.7); 7.2478 (1.5); 7.2470 (1.2); 7.2462 (1.1); 7.2454 (0.8); 7.2446 (0.8); 7.2438 (0.7); 7.2430 (0.5); 7.2093 (3.5); 7.1632 (3.8); 7.1588 (7.8); 7.1542 (3.6); 7.1396 (1.0); 7.0979 (27.8); 7.0815 (14.0); 6.9952 (3.6); 6.8758 (2.1); 6.8625 (2.1); 6.7611 (4.0); 6.0465 (0.9); 4.5238 (2.2); 4.5106 (3.5); 4.4971 (2.2); 4.3402 (3.5); 4.3157 (3.8); 4.1482 (0.5); 4.1303 (1.6); 4.1125 (1.7); 4.0945 (0.5); 3.5848 (4.2); 3.5604 (3.9); 3.1284 (3.4); 3.0865 (3.7); 2.5649 (4.2); 2.5230 (3.6); 2.1350 (1.2); 2.0989 (1.5); 2.0431 (8.0); 1.5523 (25.0); 1.4392 (0.7); 1.4250 (0.7); 1.2840 (0.5); 1.2763 (2.4); 1.2584 (5.4); 1.2406 (2.3); 0.1571 (0.6); 0.1458 (0.7); 0.0159 (0.5); 0.0151 (0.5); 0.0135 (0.6); 0.0127 (0.7); 0.0119 (0.8); 0.0080 (7.9); 0.0064 (2.7); 0.0055 (3.0); 0.0047 (3.5); -0.0002 (250.2); -0.0067 (2.9); -0.0085 (7.4); -0.0501 (1.5); -0.1495 (0.8) I.2-152: 1 H-NMR (400.0 MHz, CDCl3): δ= 7.7496 (12.3); 7.7037 (5.6); 7.4379 (0.5); 7.4205 (1.5); 7.4018 (1.3); 7.3809 (0.7); 7.3631 (0.7); 7.3020 (0.6); 7.2979 (0.6); 7.2895 (2.2); 7.2813 (1.6); 7.2749 (4.5); 7.2717 (4.7); 7.2598 (62.0); 7.1850 (4.2); 7.1654 (3.5); 7.1616 (2.7); 5.3602 (1.5); 5.3570 (1.6); 5.2846 (0.8); 4.8147 (1.7); 4.7782 (1.9); 4.6590 (0.6); 4.6172 (1.0); 4.5167 (1.1); 4.4751 (0.6); 4.3674 (2.6); 4.3534 (2.2); 4.3170 (1.8); 4.2413 (1.4); 3.4889 (0.8); 3.2271 (4.0); 3.1932 (1.9); 2.9746 (1.5); 2.9609 (9.4); 2.9515 (16.0); 2.9379 (0.9); 2.9253 (0.8); 2.7717 (0.5); 2.7655 (0.6); 2.7596 (0.6); 2.7535 (0.7); 2.7475 (0.6); 1.8688 (4.7); 1.8642 (6.5); 1.8590 (4.6); 1.7485 (2.5); 1.7439 (3.5); 1.7391 (2.4); 1.5557 (3.8); 1.2048 (6.5); 1.1866 (6.4); 1.1433 (3.3); 1.1251 (3.2); 0.0080 (0.8); -0.0002 (23.6); -0.0085 (0.7) I.2-153: 1 H-NMR (400.0 MHz, CDCl3): δ= 7.7081 (0.6); 7.6862 (16.0); 7.2611 (75.9); 6.6132 (0.7); 5.3506 (1.9); 4.5333 (2.7); 4.4471 (1.6); 3.5554 (1.1); 3.5462 (1.3); 3.5380 (1.2); 3.5295 (1.2); 3.4893 (2.7); 3.0063 (4.9); 2.7471 (0.6); 1.8541 (6.2); 1.8497 (8.1); 1.8441 (5.9); 1.3093 (4.8); 1.2912 (9.9); 1.2730 (4.8); 1.1800 (5.6); 1.1618 (5.5); 0.0080 (0.8); -0.0002 (29.0); -0.0085 (0.9) I.2-154: 1 H-NMR (400.0 MHz, CDCl 3 ): δ= 8.0493 (0.5); 8.0281 (0.6); 7.6706 (0.5); 7.5454 (1.0); 7.5409 (1.0); 7.5199 (1.8); 7.5142 (8.6); 7.5098 (9.0); 7.4902 (0.7); 7.4352 (0.5); 7.4315 (0.6); 7.2611 (114.7); 7.1132 (1.2); 7.1087 (1.8); 7.1041 (2.0); 6.9971 (0.7); 6.2263 (3.6); 5.3427 (2.3); 4.5394 (3.1); 4.4511 (1.8); 3.5589 (1.4); 3.5439 (1.8); 3.5280 (1.6); 3.5103 (1.0); 3.4889 (3.8); 3.0062 (4.2); 2.7462 (0.8); 1.9322 (0.6); 1.9279 (0.8); 1.9224 (0.6); 1.8424 (7.4); 1.8370 (10.1); 1.8324 (7.9); 1.5646 (0.8); 1.3094 (7.7); 1.2912 (16.0); 1.2731 (8.0); 1.2585 (1.3); 1.2479 (0.9); 1.2250 (0.7); 1.2088 (1.0); 1.1820 (5.2); 1.1639 (5.2); 0.0080 (1.0); -0.0002 (44.7); - 0.0085 (1.7) I.2-155: 1 H-NMR (400.0 MHz, CDCl3): δ= 8.2917 (1.6); 8.2791 (1.6); 7.6849 (16.0); 7.5189 (0.5); 7.2600 (94.6); 7.1345 (2.4); 7.0376 (1.4); 7.0342 (1.3); 7.0249 (1.4); 7.0214 (1.3); 6.9960 (0.5); 6.1709 (0.7); 5.3667 (1.5); 5.3636 (1.5); 4.5395 (2.4); 4.4676 (1.5); 4.4523 (1.5); 4.4414 (1.5); 4.4263 (1.5); 3.0025 (3.9); 2.9438 (1.2); 2.9315 (1.4); 2.7743 (0.5); 2.7683 (0.6); 2.7623 (0.6); 2.7561 (0.6); 1.8676 (4.9); 1.8633 (6.4); 1.8620 (6.4); 1.8576 (4.9); 1.5568 (3.7); 1.2023 (7.3); 1.1841 (7.2); 0.0080 (1.2); -0.0002 (37.2); -0.0085 (1.0) I.2-156: 1 H-NMR (400.0 MHz, CDCl3): δ= 8.1126 (3.6); 8.1111 (3.6); 8.0994 (3.7); 8.0980 (3.7); 7.5862 (16.0); 7.5817 (16.0); 7.5186 (1.2); 7.2727 (0.8); 7.2597 (218.9); 7.2101 (0.6); 7.1633 (4.0); 7.1588 (7.5); 7.1543 (3.8); 6.9957 (1.2); 6.8649 (2.5); 6.8613 (2.6); 6.8517 (2.4); 6.8481 (2.4); 6.7258 (3.4); 6.7241 (4.3); 6.7224 (4.3); 6.7206 (3.2); 6.0378 (0.9); 4.7958 (2.9); 4.7744 (9.3); 4.7530 (9.6); 4.7316 (3.2); 4.4954 (2.7); 4.4820 (3.9); 4.4686 (2.7); 4.3390 (3.8); 4.3146 (4.0); 4.1295 (1.0); 4.1117 (1.0); 3.5814 (4.4); 3.5571 (4.2); 3.1337 (3.6); 3.0918 (4.2); 2.5579 (4.7); 2.5161 (4.1); 2.0961 (0.6); 2.0427 (4.6); 1.5539 (25.0); 1.2760 (1.6); 1.2581 (3.6); 1.2403 (1.4); 0.8818 (0.6); 0.0079 (2.4); 0.0063 (0.8); 0.0054 (0.9); -0.0002 (82.2); -0.0068 (1.0); - 0.0085 (2.5) I.2-157: 1 H-NMR (400.0 MHz, CDCl3): δ= 8.1716 (3.6); 8.1702 (3.6); 8.1589 (3.7); 8.1574 (3.6); 7.5832 (15.9); 7.5787 (16.0); 7.5186 (1.6); 7.2840 (0.6); 7.2597 (296.4); 7.2098 (0.6); 7.1627 (3.9); 7.1581 (7.4); 7.1536 (3.7); 6.9957 (1.6); 6.5399 (2.4); 6.5366 (2.8); 6.5271 (2.3); 6.5238 (2.7); 6.4966 (4.6); 5.9512 (1.0); 4.4158 (5.5); 4.4012 (5.4); 4.3369 (4.0); 4.3125 (4.2); 4.1300 (1.0); 4.1122 (1.0); 3.8271 (8.4); 3.8151 (9.7); 3.8025 (9.7); 3.5698 (4.7); 3.5455 (4.5); 3.5100 (9.3); 3.4974 (9.1); 3.4854 (7.9); 3.1183 (4.0); 3.0763 (4.6); 2.5478 (5.1); 2.5059 (4.4); 2.0736 (10.5); 2.0430 (4.8); 1.6917 (0.6); 1.5846 (0.6); 1.5298 (21.4); 1.4288 (0.6); 1.4125 (0.6); 1.3327 (0.7); 1.2840 (0.9); 1.2762 (1.6); 1.2583 (4.1); 1.2405 (1.5); 0.0080 (3.5); 0.0055 (1.4); - 0.0002 (116.3); -0.0067 (1.6); -0.0085 (3.6) I.2-158: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.6611 (1.1); 8.6467 (2.2); 8.6331 (1.1); 7.7180 (1.0); 7.7100 (9.8); 7.7045 (3.0); 7.6929 (3.2); 7.6873 (11.7); 7.6793 (1.2); 7.4610 (2.8); 7.4578 (2.2); 7.4432 (5.5); 7.4382 (16.0); 7.4326 (4.8); 7.4209 (3.2); 7.4154 (11.0); 7.4108 (2.2); 7.3799 (1.0); 7.3741 (1.7); 7.3612 (3.6); 7.3567 (6.1); 7.3530 (3.9); 7.3481 (2.1); 7.3395 (6.1); 7.3353 (4.3); 7.3259 (4.6); 7.3219 (3.8); 7.3190 (3.4); 7.3077 (3.2); 7.3014 (2.5); 7.2962 (1.3); 7.2899 (1.9); 7.2838 (1.0); 7.2769 (1.0); 7.2713 (0.9); 6.6088 (0.9); 6.5930 (0.5); 4.3885 (7.4); 4.3741 (7.3); 4.3073 (3.0); 4.2921 (3.0); 4.0547 (2.0); 4.0331 (3.1); 4.0305 (3.5); 4.0090 (2.9); 3.9202 (2.9); 3.9052 (3.1); 3.8959 (2.1); 3.8808 (2.3); 3.3877 (0.5); 3.3653 (1.1); 3.3483 (1.7); 3.3321 (1.2); 3.3130 (31.9); 2.8194 (2.0); 2.7962 (1.9); 2.7770 (4.0); 2.7537 (3.7); 2.7133 (4.0); 2.6954 (3.7); 2.6708 (2.1); 2.6530 (1.8); 2.5232 (1.3); 2.5184 (1.9); 2.5098 (23.8); 2.5052 (51.3); 2.5006 (71.1); 2.4960 (49.8); 2.4915 (22.6); 2.0852 (1.0); 2.0726 (1.0); 0.0080 (0.7); -0.0002 (21.6); -0.0085 (0.7) I.2-159: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.6886 (1.3); 8.6749 (2.7); 8.6609 (1.4); 7.7131 (1.2); 7.7050 (11.0); 7.6995 (3.5); 7.6878 (3.7); 7.6823 (13.4); 7.6743 (1.5); 7.6200 (8.0); 7.6149 (8.5); 7.4424 (4.0); 7.4379 (16.0); 7.4324 (4.2); 7.4215 (8.8); 7.4158 (14.9); 7.4073 (1.3); 7.3880 (7.8); 7.3673 (3.6); 4.3579 (7.8); 4.3436 (7.7); 4.0470 (2.3); 4.0253 (3.6); 4.0227 (3.9); 4.0012 (3.1); 3.9096 (3.2); 3.8944 (3.4); 3.8852 (2.5); 3.8703 (2.5); 3.3764 (0.6); 3.3549 (1.2); 3.3378 (2.2); 3.3150 (48.9); 2.8146 (2.2); 2.7914 (2.2); 2.7722 (4.4); 2.7489 (4.0); 2.7038 (4.4); 2.6859 (4.1); 2.6613 (2.3); 2.6435 (2.0); 2.5236 (2.4); 2.5102 (37.8); 2.5056 (80.0); 2.5010 (110.0); 2.4964 (76.6); 2.4918 (34.5); 2.3278 (0.6); 2.0855 (1.5); 2.0731 (4.0); -0.0002 (6.2) I.2-160: 1H-NMR (400.0 MHz, d6-DMSO): δ= 8.6770 (1.3); 8.6624 (2.5); 8.6477 (1.3); 7.7140 (1.2); 7.7059 (12.4); 7.7004 (3.8); 7.6887 (3.9); 7.6831 (15.0); 7.6751 (1.6); 7.4439 (1.4); 7.4359 (16.0); 7.4304 (4.3); 7.4187 (4.0); 7.4132 (13.1); 7.4050 (2.2); 7.3985 (10.0); 7.3934 (3.6); 7.3823 (4.3); 7.3771 (16.0); 7.3709 (2.2); 7.3100 (1.7); 7.3039 (12.0); 7.2986 (3.4); 7.2874 (2.8); 7.2823 (7.7); 4.3030 (8.1); 4.2883 (8.1); 4.0343 (2.6); 4.0127 (3.8); 4.0102 (4.4); 3.9886 (3.6); 3.9012 (3.7); 3.8860 (3.9); 3.8770 (2.7); 3.8618 (2.8); 3.3356 (0.8); 3.3121 (54.3); 3.3026 (1.8); 3.2967 (2.2); 3.2803 (1.5); 3.2759 (1.2); 3.2574 (0.6); 2.8005 (2.5); 2.7773 (2.3); 2.7581 (5.2); 2.7348 (4.7); 2.6955 (5.1); 2.6775 (4.8); 2.6699 (0.8); 2.6531 (2.3); 2.6350 (2.3); 2.5233 (1.8); 2.5185 (2.6); 2.5099 (38.4); 2.5053 (84.1); 2.5007 (118.2); 2.4960 (82.7); 2.4914 (37.2); 2.3275 (0.7); 2.3229 (0.5); -0.0002 (7.1) I.2-161: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.5536 (0.6); 7.7055 (2.8); 7.7000 (0.9); 7.6883 (0.9); 7.6827 (3.4); 7.4339 (3.5); 7.4283 (1.0); 7.4166 (0.9); 7.4112 (3.1); 7.2038 (2.1); 7.1985 (0.7); 7.1873 (0.7); 7.1819 (2.4); 6.8975 (3.0); 6.8921 (0.9); 6.8809 (0.8); 6.8757 (2.6); 4.2411 (1.9); 4.2266 (1.9); 4.0226 (0.6); 4.0009 (0.9); 3.9984 (1.0); 3.9769 (0.8); 3.8915 (0.8); 3.8763 (0.9); 3.8672 (0.6); 3.8521 (0.6); 3.7290 (16.0); 3.3144 (6.9); 2.7850 (0.5); 2.7426 (1.2); 2.7194 (1.1); 2.6863 (1.2); 2.6683 (1.1); 2.6439 (0.5); 2.5097 (5.2); 2.5052 (11.3); 2.5005 (15.7); 2.4959 (11.0); 2.4913 (5.0); -0.0002 (0.9) I.2-164: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.6635 (0.8); 8.6483 (1.5); 8.6324 (0.8); 7.5306 (5.6); 7.5260 (1.9); 7.5142 (2.0); 7.5093 (6.6); 7.4047 (0.6); 7.3983 (5.8); 7.3932 (2.1); 7.3822 (2.5); 7.3769 (9.5); 7.3707 (1.3); 7.3029 (6.9); 7.2976 (2.0); 7.2864 (1.7); 7.2813 (4.5); 7.1809 (4.8); 7.1604 (4.3); 4.3031 (4.8); 4.2882 (4.8); 4.0084 (1.5); 3.9866 (2.3); 3.9841 (2.6); 3.9624 (2.1); 3.8801 (2.2); 3.8647 (2.3); 3.8558 (1.6); 3.8404 (1.7); 3.3118 (41.0); 3.2854 (1.2); 3.2678 (0.9); 2.7637 (1.3); 2.7405 (1.1); 2.7215 (3.0); 2.6982 (2.8); 2.6747 (3.3); 2.6563 (2.9); 2.6326 (1.2); 2.6141 (1.2); 2.5228 (1.5); 2.5182 (2.1); 2.5095 (28.3); 2.5049 (61.7); 2.5003 (86.1); 2.4957 (60.2); 2.4911 (27.0); 2.2757 (16.0); -0.0002 (5.4) I.2-166: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.5395 (1.2); 7.5299 (4.3); 7.5084 (4.9); 7.2396 (4.6); 7.2207 (3.5); 7.2154 (2.8); 7.2082 (2.9); 7.1813 (3.7); 7.1609 (3.4); 4.2847 (3.7); 4.2704 (3.6); 4.0219 (1.2); 3.9979 (1.9); 3.9762 (1.6); 3.8806 (1.6); 3.8655 (1.7); 3.8563 (1.2); 3.8412 (1.2); 3.3287 (0.8); 3.3119 (44.2); 2.7763 (1.1); 2.7530 (1.0); 2.7342 (2.1); 2.7108 (2.0); 2.6662 (2.5); 2.6482 (2.0); 2.6241 (1.0); 2.6061 (1.1); 2.5095 (31.0); 2.5049 (65.5); 2.5003 (89.5); 2.4957 (62.7); 2.4912 (28.4); 2.3273 (0.5); 2.2755 (12.5); 2.2492 (16.0); -0.0002 (4.6) I.2-173: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.5948 (0.5); 8.5812 (1.0); 8.5670 (0.5); 7.3452 (0.7); 7.3406 (0.8); 7.3194 (0.9); 7.3142 (0.8); 7.1915 (0.9); 7.1878 (1.0); 7.1790 (0.9); 7.1757 (1.1); 7.1711 (0.6); 7.1676 (0.7); 7.1587 (0.7); 7.1560 (0.8); 7.1433 (1.0); 7.1287 (1.2); 7.1255 (1.0); 7.1097 (0.5); 4.3616 (2.8); 4.3476 (2.9); 4.3009 (0.7); 4.2821 (1.0); 4.2627 (0.7); 3.5234 (1.2); 3.4999 (2.0); 3.4779 (1.6); 3.3445 (1.5); 3.3291 (1.7); 3.3207 (1.2); 3.3052 (1.3); 3.1411 (0.6); 3.1374 (0.6); 3.1257 (0.6); 3.1196 (0.9); 3.1153 (0.6); 3.1030 (0.6); 2.5106 (8.0); 2.5060 (18.0); 2.5014 (25.8); 2.4968 (18.6); 2.4922 (8.8); 2.4818 (1.3); 2.4585 (0.9); 2.4403 (2.6); 2.4170 (2.4); 2.4045 (2.6); 2.3858 (2.4); 2.3631 (0.9); 2.3444 (0.8); 2.0857 (16.0); 1.6807 (0.8); 1.6740 (1.0); 1.6566 (1.1); 1.6445 (1.6); 1.6353 (1.4); 1.6313 (1.4); 1.6264 (1.4); 1.6165 (0.9); 1.5357 (0.7); 1.5265 (1.1); 1.5171 (1.4); 1.5072 (2.0); 1.4920 (1.4); 1.4827 (1.1); 1.4706 (0.8); 1.4624 (0.6); -0.0002 (2.6) I.2-174: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.4693 (0.5); 8.4557 (1.0); 8.4414 (0.5); 7.2354 (0.5); 7.2301 (0.6); 7.2162 (1.4); 7.2104 (4.6); 7.2042 (5.0); 7.2026 (5.7); 7.1817 (0.8); 4.2616 (1.7); 4.2498 (2.2); 4.2368 (1.7); 3.5437 (1.3); 3.5216 (2.2); 3.5197 (2.4); 3.4976 (3.2); 3.4791 (3.8); 3.3850 (1.6); 3.3704 (1.8); 3.3610 (1.2); 3.3463 (1.4); 3.1946 (0.5); 3.1899 (0.6); 3.1799 (0.5); 3.1727 (0.8); 3.1575 (0.6); 3.0298 (0.7); 3.0104 (0.8); 2.9967 (1.5); 2.9771 (1.6); 2.9430 (1.4); 2.9250 (1.5); 2.9097 (0.7); 2.8917 (0.7); 2.5234 (0.7); 2.5188 (1.0); 2.5101 (19.3); 2.5055 (42.6); 2.5009 (60.1); 2.4962 (42.1); 2.4916 (18.7); 2.4699 (2.0); 2.4466 (2.0); 2.4390 (2.1); 2.4211 (1.9); 2.3976 (0.7); 2.3797 (0.5); 2.2372 (16.0); 1.8551 (0.7); 1.8377 (0.9); 1.8200 (0.7); 0.8239 (9.1); 0.8070 (10.7); 0.8051 (11.2); 0.7883 (9.0); 0.0080 (0.7); -0.0002 (29.8); -0.0085 (0.9) I.2-175: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.5627 (1.6); 8.5479 (3.0); 8.5337 (1.6); 7.3064 (5.6); 7.3009 (2.3); 7.2925 (6.4); 7.2843 (8.1); 7.2761 (2.8); 7.2704 (7.6); 7.2629 (0.8); 7.1794 (1.2); 7.1720 (10.2); 7.1665 (2.8); 7.1555 (3.0); 7.1496 (16.0); 7.1438 (3.0); 7.1328 (2.5); 7.1273 (7.3); 7.1198 (0.7); 4.4869 (0.7); 4.4667 (1.7); 4.4430 (3.4); 4.4231 (1.9); 4.3992 (0.8); 4.2738 (9.8); 4.2590 (9.7); 3.6510 (3.6); 3.6277 (6.3); 3.6051 (4.8); 3.4492 (4.6); 3.4331 (5.2); 3.4253 (3.8); 3.4093 (4.2); 3.3493 (29.5); 3.1617 (1.0); 3.1456 (1.3); 3.1395 (2.2); 3.1231 (2.3); 3.1197 (2.7); 3.1032 (2.3); 3.0972 (1.4); 3.0810 (1.0); 2.6744 (0.9); 2.6699 (1.3); 2.6653 (0.9); 2.5233 (4.0); 2.5186 (5.7); 2.5100 (74.4); 2.5054 (161.6); 2.5008 (225.3); 2.4961 (155.9); 2.4916 (68.6); 2.4622 (2.0); 2.4555 (1.4); 2.4507 (1.8); 2.4435 (9.4); 2.4284 (9.2); 2.4206 (8.8); 2.4085 (8.5); 2.3868 (1.8); 2.3669 (1.4); 2.3322 (1.2); 2.3276 (1.5); 2.3229 (1.1); 2.2239 (0.5); 2.1994 (1.7); 2.1949 (1.6); 2.1809 (2.2); 2.1751 (3.1); 2.1706 (3.2); 2.1637 (1.3); 2.1560 (2.9); 2.1517 (3.7); 2.1462 (3.0); 2.1320 (1.8); 2.1276 (2.7); 2.1031 (0.8); 2.0033 (1.4); 1.9926 (2.2); 1.9876 (2.4); 1.9805 (2.8); 1.9754 (3.1); 1.9687 (3.4); 1.9600 (3.2); 1.9488 (2.2); 1.9439 (2.0); 1.9328 (1.2); 1.6546 (1.2); 1.6484 (1.0); 1.6384 (3.5); 1.6295 (2.6); 1.6249 (3.4); 1.6140 (6.5); 1.6007 (3.7); 1.5894 (2.9); 1.5748 (1.1); 0.0080 (2.8); 0.0063 (1.0); 0.0055 (1.1); 0.0046 (1.3); -0.0002 (90.0); -0.0052 (1.2); -0.0060 (0.9); -0.0068 (0.8); - 0.0085 (2.6) I.2-176: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.5589 (1.6); 8.5446 (3.0); 8.5302 (1.6); 7.3547 (0.6); 7.3500 (2.5); 7.3475 (4.8); 7.3440 (1.6); 7.3356 (2.7); 7.3338 (2.4); 7.3289 (8.3); 7.3264 (10.1); 7.3185 (2.2); 7.3110 (11.8); 7.3064 (2.2); 7.2621 (14.4); 7.2607 (16.0); 7.2532 (3.2); 7.2492 (2.5); 7.2438 (11.0); 7.2399 (6.3); 7.2381 (5.8); 7.2329 (0.9); 7.2298 (1.4); 7.2261 (2.0); 7.2226 (0.9); 4.4902 (0.7); 4.4703 (1.8); 4.4666 (1.8); 4.4466 (3.5); 4.4266 (2.0); 4.4226 (1.9); 4.4027 (0.9); 4.2970 (10.9); 4.2822 (10.8); 4.2586 (0.6); 4.2436 (0.7); 4.2321 (0.6); 4.1315 (1.0); 3.6588 (3.8); 3.6353 (6.5); 3.6129 (5.1); 3.4603 (4.7); 3.4442 (5.2); 3.4364 (3.8); 3.4204 (4.2); 3.1753 (1.0); 3.1592 (1.3); 3.1533 (2.4); 3.1389 (2.2); 3.1369 (2.5); 3.1331 (2.9); 3.1168 (2.5); 3.1108 (1.4); 3.0947 (1.0); 2.5233 (0.7); 2.5186 (1.2); 2.5099 (18.7); 2.5053 (41.2); 2.5007 (57.6); 2.4961 (40.3); 2.4915 (19.1); 2.4685 (1.3); 2.4496 (9.6); 2.4381 (9.3); 2.4269 (9.0); 2.4180 (8.9); 2.3964 (1.5); 2.3764 (1.1); 2.2277 (0.5); 2.2102 (0.8); 2.2031 (1.6); 2.1987 (1.5); 2.1925 (0.8); 2.1854 (2.2); 2.1813 (2.4); 2.1785 (2.8); 2.1743 (3.2); 2.1679 (1.4); 2.1610 (2.9); 2.1570 (3.4); 2.1545 (2.7); 2.1500 (3.0); 2.1434 (1.1); 2.1370 (1.8); 2.1327 (2.6); 2.1257 (1.2); 2.1082 (0.8); 2.0054 (1.3); 1.9947 (2.2); 1.9891 (2.2); 1.9864 (2.2); 1.9823 (2.6); 1.9765 (3.4); 1.9710 (3.5); 1.9652 (3.1); 1.9615 (3.2); 1.9571 (2.7); 1.9511 (2.3); 1.9461 (2.0); 1.9415 (1.4); 1.9351 (1.0); 1.6554 (1.2); 1.6481 (0.9); 1.6393 (3.6); 1.6303 (2.7); 1.6261 (3.5); 1.6150 (6.6); 1.6017 (3.6); 1.5904 (3.0); 1.5788 (0.9); 1.5756 (1.0); -0.0002 (5.8) I.2-177: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.4635 (0.5); 7.1850 (2.0); 7.1797 (0.6); 7.1685 (0.7); 7.1631 (2.3); 6.8958 (2.9); 6.8904 (0.8); 6.8792 (0.8); 6.8739 (2.5); 4.4424 (0.6); 4.2182 (1.9); 4.2036 (1.9); 3.7275 (16.0); 3.6413 (0.6); 3.6181 (1.0); 3.5955 (0.8); 3.4417 (0.7); 3.4256 (0.8); 3.4179 (0.6); 3.4018 (0.6); 2.5101 (2.8); 2.5055 (6.2); 2.5008 (8.6); 2.4962 (6.0); 2.4916 (2.6); 2.4318 (1.5); 2.4219 (1.5); 2.4092 (1.4); 2.4017 (1.4); 2.1529 (0.6); 1.9734 (0.6); 1.9692 (0.5); 1.9581 (0.5); 1.6373 (0.6); 1.6239 (0.5); 1.6129 (1.0); 1.5995 (0.6); -0.0002 (1.0) I.2-178: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.5905 (1.3); 8.5758 (2.6); 8.5611 (1.3); 7.4038 (1.2); 7.3974 (10.8); 7.3924 (3.6); 7.3812 (4.4); 7.3760 (16.0); 7.3698 (1.9); 7.2901 (1.7); 7.2840 (12.3); 7.2787 (3.4); 7.2675 (3.0); 7.2624 (8.3); 7.2562 (0.8); 4.4878 (0.5); 4.4679 (1.4); 4.4644 (1.4); 4.4441 (2.7); 4.4241 (1.5); 4.4201 (1.4); 4.4004 (0.6); 4.2803 (8.6); 4.2655 (8.5); 3.6543 (4.7); 3.6311 (7.0); 3.6085 (4.8); 3.4516 (3.7); 3.4356 (4.0); 3.4277 (3.0); 3.4117 (3.2); 3.1695 (0.8); 3.1533 (1.0); 3.1494 (1.6); 3.1473 (1.7); 3.1335 (1.6); 3.1307 (1.8); 3.1276 (2.2); 3.1112 (1.8); 3.1050 (1.1); 3.0889 (0.8); 2.5240 (0.7); 2.5194 (1.0); 2.5107 (13.8); 2.5061 (30.2); 2.5014 (42.1); 2.4968 (29.4); 2.4922 (13.3); 2.4672 (1.2); 2.4485 (7.0); 2.4308 (7.1); 2.4256 (6.6); 2.4111 (6.4); 2.3891 (1.5); 2.3694 (1.2); 2.2002 (1.3); 2.1961 (1.2); 2.1886 (0.6); 2.1805 (1.7); 2.1759 (2.5); 2.1716 (2.4); 2.1643 (1.0); 2.1564 (2.2); 2.1524 (3.0); 2.1474 (2.3); 2.1401 (0.8); 2.1323 (1.4); 2.1282 (2.1); 2.1037 (0.6); 2.0035 (1.0); 1.9925 (1.8); 1.9883 (1.8); 1.9805 (2.2); 1.9766 (2.6); 1.9721 (2.3); 1.9686 (2.6); 1.9644 (2.2); 1.9606 (2.5); 1.9573 (2.4); 1.9522 (1.6); 1.9486 (1.7); 1.9446 (1.6); 1.9327 (1.0); 1.9291 (0.7); 1.6551 (0.9); 1.6477 (0.7); 1.6389 (2.8); 1.6300 (2.1); 1.6256 (2.6); 1.6146 (5.1); 1.6012 (2.8); 1.5899 (2.3); 1.5753 (0.8); -0.0002 (4.7) I.2-179: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.5694 (1.4); 8.5553 (2.7); 8.5414 (1.4); 7.4597 (2.8); 7.4568 (5.0); 7.4536 (2.6); 7.4412 (3.7); 7.4389 (7.0); 7.4357 (3.9); 7.3465 (3.4); 7.3428 (7.5); 7.3410 (4.3); 7.3328 (16.0); 7.3301 (13.6); 7.3224 (6.4); 7.3117 (3.1); 7.3096 (1.7); 7.3039 (3.3); 7.2989 (1.2); 7.2929 (2.9); 7.2809 (1.1); 4.4916 (0.6); 4.4720 (1.4); 4.4482 (2.8); 4.4283 (1.5); 4.4243 (1.5); 4.4042 (0.8); 4.3638 (10.2); 4.3493 (10.1); 3.6733 (3.1); 3.6499 (5.3); 3.6275 (4.2); 3.5015 (3.6); 3.4738 (5.4); 3.4579 (5.0); 3.4499 (3.7); 3.4340 (3.8); 3.2194 (0.9); 3.2036 (1.0); 3.1974 (1.7); 3.1839 (1.6); 3.1809 (1.9); 3.1779 (2.2); 3.1616 (1.8); 3.1553 (1.2); 3.1393 (0.8); 2.6744 (0.6); 2.6699 (0.9); 2.6652 (0.6); 2.5234 (1.9); 2.5187 (2.7); 2.5100 (45.9); 2.5054 (102.4); 2.5007 (143.4); 2.4961 (99.2); 2.4915 (43.7); 2.4845 (2.9); 2.4656 (7.6); 2.4557 (1.1); 2.4468 (8.1); 2.4426 (7.4); 2.4273 (6.9); 2.4052 (1.7); 2.3856 (1.3); 2.3322 (0.6); 2.3276 (0.9); 2.3230 (0.7); 2.2073 (1.4); 2.2032 (1.2); 2.1826 (3.0); 2.1789 (2.7); 2.1717 (1.0); 2.1618 (2.4); 2.1583 (3.5); 2.1545 (2.7); 2.1377 (1.4); 2.1339 (2.4); 2.1094 (0.7); 2.0060 (1.0); 1.9950 (2.0); 1.9906 (1.8); 1.9802 (2.8); 1.9750 (2.9); 1.9711 (2.3); 1.9677 (2.1); 1.9647 (2.5); 1.9606 (2.8); 1.9558 (1.8); 1.9504 (1.8); 1.9476 (1.6); 1.9358 (0.9); 1.6578 (1.0); 1.6526 (0.7); 1.6420 (2.9); 1.6327 (2.3); 1.6290 (2.9); 1.6177 (5.3); 1.6044 (2.8); 1.5931 (2.5); 1.5782 (0.9); 0.0080 (1.7); -0.0002 (61.3); -0.0052 (0.6); -0.0085 (1.7) I.2-180: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.5511 (0.8); 8.5366 (1.5); 8.5221 (0.8); 7.3014 (3.0); 7.2959 (1.2); 7.2875 (3.1); 7.2793 (4.4); 7.2711 (1.4); 7.2654 (3.7); 7.2578 (0.5); 7.1740 (0.6); 7.1667 (4.9); 7.1611 (1.3); 7.1501 (1.5); 7.1442 (7.7); 7.1384 (1.5); 7.1274 (1.2); 7.1220 (3.6); 4.2699 (4.2); 4.2551 (4.1); 4.0348 (0.7); 3.5247 (1.8); 3.5025 (2.8); 3.5008 (3.1); 3.4787 (2.6); 3.3816 (2.4); 3.3666 (2.7); 3.3574 (1.8); 3.3425 (2.1); 3.3236 (40.5); 3.1784 (0.5); 3.1634 (0.6); 3.1596 (0.9); 3.1562 (1.0); 3.1446 (0.9); 3.1409 (1.1); 3.1376 (1.3); 3.1341 (0.8); 3.1223 (1.1); 3.1191 (0.7); 3.1151 (0.6); 3.0197 (1.0); 3.0003 (1.0); 2.9865 (2.5); 2.9670 (2.6); 2.9474 (2.4); 2.9293 (2.5); 2.9141 (1.0); 2.8960 (1.0); 2.5194 (0.5); 2.5107 (7.7); 2.5061 (17.0); 2.5015 (24.0); 2.4969 (16.7); 2.4923 (7.4); 2.4770 (0.6); 2.4582 (3.2); 2.4517 (0.5); 2.4417 (3.5); 2.4355 (3.2); 2.4229 (3.2); 2.4002 (0.6); 2.3814 (0.5); 1.8688 (0.6); 1.8511 (1.1); 1.8341 (1.4); 1.8170 (1.1); 1.7989 (0.6); 0.8219 (14.1); 0.8084 (16.0); 0.8053 (15.6); 0.7918 (13.8); -0.0002 (2.8) I.2-181: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.5982 (2.4); 8.5838 (4.7); 8.5695 (2.4); 7.6185 (15.5); 7.6133 (16.0); 7.4450 (7.3); 7.4396 (6.6); 7.4242 (11.4); 7.4188 (11.0); 7.3573 (13.6); 7.3364 (8.5); 4.4885 (0.9); 4.4689 (2.3); 4.4653 (2.2); 4.4451 (4.4); 4.4251 (2.5); 4.4213 (2.4); 4.4014 (1.0); 4.3339 (14.7); 4.3196 (14.5); 3.6656 (4.8); 3.6421 (8.2); 3.6197 (6.4); 3.4628 (20.1); 3.4473 (14.3); 3.4391 (8.6); 3.4232 (6.8); 3.2100 (1.4); 3.1939 (1.7); 3.1905 (2.4); 3.1877 (2.6); 3.1746 (2.4); 3.1710 (3.0); 3.1686 (3.4); 3.1521 (2.7); 3.1457 (1.8); 3.1297 (1.2); 2.6750 (0.7); 2.6703 (1.0); 2.6658 (0.7); 2.5239 (2.4); 2.5192 (3.4); 2.5105 (50.4); 2.5059 (111.8); 2.5013 (155.8); 2.4966 (108.2); 2.4920 (47.2); 2.4807 (3.2); 2.4621 (11.2); 2.4561 (1.6); 2.4514 (1.8); 2.4466 (1.7); 2.4383 (17.8); 2.4185 (10.3); 2.3962 (2.9); 2.3768 (2.5); 2.3327 (0.7); 2.3281 (1.0); 2.3234 (0.7); 2.2276 (0.7); 2.2027 (2.3); 2.1991 (2.0); 2.1887 (1.4); 2.1781 (4.8); 2.1746 (4.2); 2.1646 (1.6); 2.1568 (3.9); 2.1535 (5.6); 2.1501 (4.4); 2.1431 (1.4); 2.1325 (2.3); 2.1290 (3.7); 2.1045 (1.0); 2.0856 (2.9); 2.0049 (1.4); 1.9928 (3.2); 1.9886 (2.8); 1.9795 (4.1); 1.9738 (4.5); 1.9675 (3.5); 1.9631 (3.8); 1.9598 (4.1); 1.9546 (2.7); 1.9483 (3.0); 1.9347 (1.3); 1.6572 (1.6); 1.6518 (1.2); 1.6411 (4.5); 1.6320 (3.5); 1.6279 (4.5); 1.6168 (8.3); 1.6034 (4.6); 1.5922 (3.8); 1.5774 (1.3); -0.0002 (17.0) I.2-182: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.4837 (0.6); 8.4697 (1.1); 8.4562 (0.6); 7.2339 (0.8); 7.2145 (7.1); 7.2070 (3.5); 7.2056 (3.2); 7.1863 (0.6); 4.4657 (0.6); 4.4451 (1.1); 4.4255 (0.6); 4.2630 (2.2); 4.2586 (2.1); 4.2488 (2.2); 4.2443 (2.1); 3.6694 (1.2); 3.6461 (2.0); 3.6237 (1.6); 3.4568 (1.5); 3.4412 (1.6); 3.4327 (1.1); 3.4172 (1.3); 3.3201 (159.6); 3.2704 (1.1); 3.1744 (0.6); 3.1624 (0.6); 3.1563 (0.8); 3.1399 (0.6); 2.6700 (0.5); 2.5235 (1.3); 2.5188 (1.9); 2.5101 (29.1); 2.5055 (63.8); 2.5009 (89.5); 2.4963 (62.3); 2.4917 (27.5); 2.4765 (1.1); 2.4581 (2.9); 2.4514 (0.8); 2.4468 (0.6); 2.4348 (2.4); 2.4257 (2.5); 2.4067 (2.4); 2.3841 (0.8); 2.3651 (0.7); 2.3277 (0.6); 2.2412 (16.0); 2.2042 (0.6); 2.1995 (0.5); 2.1793 (1.2); 2.1754 (1.2); 2.1552 (1.2); 2.1512 (1.6); 2.1311 (0.6); 2.1269 (1.0); 1.9964 (0.7); 1.9843 (0.9); 1.9793 (1.0); 1.9731 (1.1); 1.9672 (1.0); 1.9640 (1.0); 1.9529 (0.7); 1.9481 (0.7); 1.6411 (1.1); 1.6279 (1.1); 1.6167 (2.1); 1.6033 (1.2); 1.5921 (1.0); -0.0002 (1.8) I.3-1: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 9.2398 (5.1); 8.5853 (1.3); 8.1448 (5.0); 8.1417 (5.3); 8.0266 (2.0); 8.0181 (2.2); 8.0111 (3.3); 8.0064 (2.0); 8.0028 (2.2); 7.9969 (2.0); 7.6993 (1.5); 7.6781 (1.9); 7.6664 (7.3); 7.6605 (7.4); 7.6103 (10.0); 7.6081 (9.9); 7.6020 (4.7); 7.5986 (4.7); 7.5948 (5.4); 7.5749 (0.8); 7.4210 (4.5); 7.4149 (4.2); 7.3993 (3.8); 7.3933 (3.6); 4.9844 (1.0); 4.2768 (2.4); 4.2596 (2.6); 4.2506 (3.0); 4.2336 (2.4); 4.0559 (1.2); 4.0381 (3.5); 4.0204 (3.5); 4.0025 (1.2); 3.8234 (1.8); 3.8151 (1.9); 3.7968 (1.6); 3.7893 (1.7); 3.3652 (0.6); 3.3083 (239.8); 3.2782 (1.0); 3.2631 (0.7); 3.2571 (1.0); 3.0835 (2.4); 3.0629 (2.7); 3.0401 (3.0); 3.0195 (2.7); 2.6738 (1.9); 2.6694 (2.7); 2.6649 (1.9); 2.6000 (2.2); 2.5920 (2.5); 2.5227 (16.1); 2.5179 (21.3); 2.5094 (159.3); 2.5049 (328.5); 2.5003 (452.2); 2.4957 (325.7); 2.4912 (153.7); 2.3939 (0.8); 2.3317 (2.2); 2.3271 (2.8); 2.3227 (2.2); 2.0723 (0.6); 1.9877 (16.0); 1.2459 (1.5); 1.1923 (4.3); 1.1745 (8.5); 1.1567 (4.2); 0.8752 (0.8); 0.8583 (2.2); 0.8406 (0.8); -0.0002 (13.6) I.3-2: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.7226 (1.7); 8.7072 (1.6); 7.6936 (4.6); 7.6878 (1.6); 7.6813 (5.1); 7.6759 (2.5); 7.6704 (5.3); 7.6639 (1.8); 7.6581 (5.2); 7.4779 (5.2); 7.4715 (5.7); 7.4582 (5.4); 7.4368 (8.4); 7.3655 (4.6); 7.3590 (4.0); 7.3441 (2.9); 7.3376 (2.6); 7.2416 (5.2); 7.2357 (1.4); 7.2197 (7.1); 7.2026 (1.4); 7.1969 (4.6); 4.4172 (1.1); 4.1515 (2.3); 4.1346 (2.4); 4.1259 (2.9); 4.1093 (2.2); 3.6352 (2.2); 3.6275 (2.3); 3.6105 (16.0); 3.6023 (2.7); 3.3447 (0.6); 3.3128 (133.3); 3.3104 (175.4); 2.9460 (2.1); 2.9257 (2.4); 2.9032 (2.7); 2.8830 (2.4); 2.6741 (2.1); 2.6695 (2.8); 2.6648 (2.0); 2.5505 (0.9); 2.5230 (6.9); 2.5182 (10.4); 2.5096 (156.4); 2.5050 (344.5); 2.5004 (484.3); 2.4957 (340.7); 2.4912 (153.8); 2.4250 (2.3); 2.4160 (2.5); 2.3821 (2.0); 2.3734 (2.1); 2.3319 (2.1); 2.3272 (2.9); 2.3225 (2.1); 2.0726 (0.8); 0.0080 (1.8); -0.0002 (66.3); -0.0086 (1.8) I.3-3: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.7233 (2.0); 8.7066 (1.9); 7.5361 (0.6); 7.5296 (0.7); 7.5031 (0.9); 7.4910 (4.1); 7.4853 (4.7); 7.4756 (6.5); 7.4691 (8.6); 7.4608 (9.6); 7.4541 (1.6); 7.4485 (1.0); 7.4396 (9.9); 7.4281 (0.6); 7.3900 (0.5); 7.3835 (0.5); 7.3667 (5.2); 7.3602 (4.6); 7.3453 (3.3); 7.3388 (3.0); 7.0378 (0.8); 7.0320 (1.3); 7.0264 (0.8); 7.0149 (1.7); 7.0091 (2.7); 7.0033 (1.3); 6.9914 (1.0); 6.9860 (1.4); 5.7539 (1.0); 4.4504 (0.5); 4.4424 (0.8); 4.4334 (1.2); 4.4231 (1.1); 4.4152 (1.2); 4.4065 (0.9); 4.3979 (0.6); 4.1424 (2.3); 4.1256 (2.5); 4.1162 (3.0); 4.0994 (2.3); 3.7247 (2.0); 3.6659 (2.3); 3.6587 (2.2); 3.6398 (2.1); 3.6326 (2.1); 3.6048 (16.0); 3.3125 (42.0); 3.0086 (2.4); 2.9883 (2.6); 2.9654 (3.0); 2.9452 (2.6); 2.6744 (0.9); 2.6698 (1.2); 2.6651 (0.9); 2.5232 (3.9); 2.5185 (5.7); 2.5098 (73.6); 2.5053 (158.5); 2.5006 (221.2); 2.4960 (154.1); 2.4914 (68.4); 2.4631 (2.7); 2.4546 (2.8); 2.4199 (2.1); 2.4115 (2.1); 2.3321 (1.0); 2.3275 (1.3); 2.3228 (0.9); -0.0002 (7.0) I.3-5: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.7291 (2.1); 8.7132 (2.1); 7.8955 (4.5); 7.8897 (1.9); 7.8785 (3.0); 7.8726 (15.0); 7.8532 (14.5); 7.8473 (2.9); 7.8360 (1.7); 7.8303 (4.2); 7.4737 (5.8); 7.4673 (6.3); 7.4557 (5.9); 7.4343 (9.1); 7.3638 (4.7); 7.3572 (4.4); 7.3424 (3.1); 7.3358 (3.0); 5.7522 (5.5); 4.4386 (1.2); 4.1940 (2.3); 4.1771 (2.3); 4.1679 (2.8); 4.1514 (2.4); 4.0380 (0.5); 4.0205 (0.6); 3.7054 (2.2); 3.6980 (2.2); 3.6790 (2.0); 3.6720 (1.9); 3.6040 (16.0); 3.3057 (50.4); 3.0175 (2.3); 2.9972 (2.5); 2.9742 (2.9); 2.9542 (2.6); 2.6737 (1.4); 2.6692 (2.0); 2.6645 (1.3); 2.5226 (5.3); 2.5178 (7.7); 2.5092 (117.0); 2.5047 (250.0); 2.5001 (344.6); 2.4955 (241.8); 2.4910 (109.1); 2.4743 (2.9); 2.4399 (2.3); 2.4308 (2.0); 2.3317 (1.5); 2.3269 (2.0); 2.0101 (0.6); 1.9876 (2.3); 1.3457 (0.6); 1.3342 (0.8); 1.2392 (0.5); 1.1924 (0.6); 1.1746 (1.2); 1.1568 (0.6); 0.8882 (0.6); 0.8714 (0.7); 0.1460 (0.7); 0.0080 (5.0); -0.0002 (171.6); -0.0085 (5.3); -0.1494 (0.6) I.3-6: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.7226 (1.5); 8.7061 (1.5); 7.5379 (6.0); 7.5331 (1.9); 7.5214 (2.1); 7.5166 (6.7); 7.4888 (0.5); 7.4788 (4.1); 7.4723 (4.6); 7.4581 (4.4); 7.4367 (6.8); 7.3657 (3.9); 7.3592 (3.4); 7.3443 (2.4); 7.3378 (2.2); 7.1893 (4.7); 7.1689 (4.2); 5.7549 (0.6); 4.4242 (0.7); 4.4154 (0.8); 4.4073 (0.8); 4.3958 (0.8); 4.3872 (0.7); 4.1268 (1.8); 4.1101 (2.0); 4.1012 (2.3); 4.0845 (1.7); 3.7234 (0.7); 3.6190 (2.2); 3.6105 (12.5); 3.5935 (1.6); 3.5861 (1.5); 3.3694 (1.4); 3.3543 (0.6); 3.3517 (0.8); 3.3197 (533.8); 3.2703 (4.1); 2.9331 (1.7); 2.9128 (2.0); 2.8904 (2.1); 2.8700 (1.9); 2.6746 (1.0); 2.6701 (1.5); 2.6654 (1.1); 2.5341 (0.6); 2.5236 (3.5); 2.5189 (5.0); 2.5102 (79.8); 2.5056 (177.0); 2.5010 (249.4); 2.4963 (173.3); 2.4917 (76.1); 2.4604 (1.1); 2.4559 (1.9); 2.4512 (2.6); 2.4466 (1.9); 2.4128 (1.9); 2.4037 (2.0); 2.3702 (1.6); 2.3611 (1.6); 2.3324 (1.2); 2.3278 (1.7); 2.3231 (1.1); 2.2790 (16.0); 2.0731 (1.4); -0.0002 (2.3) I.3-7: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.7216 (0.9); 8.7053 (0.9); 7.5552 (3.4); 7.5496 (1.1); 7.5379 (1.2); 7.5324 (3.6); 7.4811 (2.1); 7.4747 (2.3); 7.4598 (2.0); 7.4384 (3.0); 7.3669 (1.6); 7.3605 (1.4); 7.3455 (1.0); 7.3390 (0.9); 6.9537 (3.7); 6.9481 (1.0); 6.9363 (1.1); 6.9309 (3.3); 4.1174 (0.9); 4.1006 (0.9); 4.0919 (1.1); 4.0752 (0.8); 3.7425 (16.0); 3.6139 (5.9); 3.6014 (1.0); 3.5936 (0.9); 3.5756 (0.8); 3.5682 (0.8); 3.3183 (33.3); 2.9147 (0.8); 2.8944 (0.9); 2.8722 (1.0); 2.8518 (0.9); 2.5234 (1.5); 2.5101 (14.9); 2.5056 (29.8); 2.5011 (39.8); 2.4966 (28.0); 2.4921 (13.0); 2.3980 (1.0); 2.3890 (0.9); 2.3555 (0.8); 2.3464 (0.8); 0.0080 (0.6); -0.0002 (15.0); -0.0084 (0.6) I.3-8: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.7062 (2.0); 8.6897 (2.0); 7.7218 (0.9); 7.7137 (9.0); 7.7083 (2.7); 7.6966 (2.9); 7.6910 (10.8); 7.6830 (1.1); 7.4538 (1.2); 7.4458 (11.4); 7.4403 (3.0); 7.4286 (2.9); 7.4232 (9.6); 7.4174 (2.9); 7.4109 (1.5); 7.4058 (2.6); 7.4019 (2.2); 7.3943 (3.6); 7.3855 (0.5); 7.3652 (1.9); 7.3577 (1.6); 7.3540 (2.6); 7.3482 (1.6); 7.3420 (3.2); 7.2948 (1.2); 7.2905 (0.8); 7.2834 (6.7); 7.2823 (6.3); 7.2764 (3.9); 7.2720 (4.2); 7.2702 (4.4); 7.2659 (3.1); 7.2595 (5.1); 7.2475 (0.6); 4.4429 (0.8); 4.4338 (1.0); 4.4263 (1.0); 4.4230 (1.0); 4.4151 (1.0); 4.4064 (0.8); 4.1509 (2.2); 4.1340 (2.3); 4.1252 (2.7); 4.1085 (2.1); 3.6492 (2.0); 3.6416 (2.0); 3.6236 (1.9); 3.6161 (1.9); 3.5883 (16.0); 3.3209 (108.5); 3.2705 (1.0); 2.9626 (2.2); 2.9423 (2.3); 2.9197 (2.7); 2.8994 (2.4); 2.5237 (1.0); 2.5190 (1.5); 2.5102 (20.8); 2.5057 (45.7); 2.5011 (64.0); 2.4965 (45.0); 2.4919 (20.3); 2.4600 (0.5); 2.4554 (0.7); 2.4508 (1.0); 2.4458 (2.7); 2.4366 (2.3); 2.4028 (2.0); 2.3938 (2.0); -0.0002 (4.4) I.3-9: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.7283 (2.2); 8.7122 (2.1); 7.7201 (1.1); 7.7120 (10.2); 7.7064 (3.1); 7.6948 (3.3); 7.6892 (12.3); 7.6812 (1.1); 7.4769 (5.7); 7.4706 (6.0); 7.4583 (6.3); 7.4537 (1.4); 7.4458 (13.0); 7.4401 (3.9); 7.4370 (9.7); 7.4285 (3.0); 7.4230 (10.5); 7.4150 (0.8); 7.3660 (5.2); 7.3595 (4.6); 7.3446 (3.3); 7.3381 (3.0); 4.4280 (1.0); 4.4199 (1.0); 4.4084 (1.0); 4.3998 (0.8); 4.1497 (2.3); 4.1329 (2.5); 4.1240 (2.9); 4.1073 (2.1); 3.6427 (2.2); 3.6354 (2.1); 3.6166 (2.6); 3.6078 (16.0); 3.3682 (0.8); 3.3510 (0.7); 3.3184 (408.3); 3.2683 (3.6); 2.9644 (2.4); 2.9441 (2.5); 2.9215 (2.9); 2.9012 (2.5); 2.6748 (1.0); 2.6700 (1.5); 2.6654 (1.0); 2.5236 (3.5); 2.5189 (5.0); 2.5102 (75.1); 2.5056 (166.7); 2.5010 (234.6); 2.4963 (162.9); 2.4917 (71.5); 2.4604 (1.1); 2.4556 (1.8); 2.4510 (2.4); 2.4464 (1.9); 2.4374 (2.7); 2.4285 (2.4); 2.3945 (2.1); 2.3856 (2.0); 2.3325 (1.1); 2.3278 (1.5); 2.3231 (1.0); 2.0735 (1.0); 1.9884 (2.1); 1.1923 (0.6); 1.1745 (1.4); 1.1566 (0.7); 0.0081 (1.5); 0.0041 (0.6); 0.0024 (1.6); -0.0002 (53.7); -0.0085 (1.6); -0.0502 (0.6) I.3-10: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.7826 (0.6); 7.7758 (0.7); 7.5032 (1.5); 7.4688 (5.6); 7.4626 (6.1); 7.4576 (6.3); 7.4363 (7.9); 7.4199 (0.6); 7.4054 (0.7); 7.3573 (4.5); 7.3507 (3.8); 7.3358 (3.1); 7.3293 (3.1); 7.3084 (0.7); 7.2734 (0.6); 7.2542 (2.0); 7.2361 (0.5); 7.0150 (1.6); 5.7538 (2.1); 4.5594 (1.1); 4.0380 (1.3); 4.0202 (1.2); 3.5680 (16.0); 3.3107 (324.8); 3.2608 (1.9); 3.1912 (0.6); 2.6741 (1.9); 2.6695 (2.7); 2.6648 (1.9); 2.5230 (6.7); 2.5183 (9.7); 2.5096 (147.3); 2.5050 (326.1); 2.5004 (460.0); 2.4957 (319.1); 2.4911 (140.6); 2.4595 (2.2); 2.4550 (3.2); 2.4504 (3.9); 2.4459 (2.7); 2.4007 (0.7); 2.3806 (1.0); 2.3319 (2.1); 2.3272 (2.9); 2.3225 (2.0); 2.0725 (0.8); 1.9878 (5.3); 1.2354 (1.0); 1.1923 (2.0); 1.1745 (3.6); 1.1567 (1.9); 0.1459 (0.8); 0.0080 (7.6); 0.0064 (1.2); 0.0055 (1.3); 0.0047 (1.7); 0.0038 (2.8); 0.0022 (9.2); -0.0002 (295.3); -0.0043 (6.6); -0.0052 (4.9); -0.0060 (4.1); -0.0068 (3.6); -0.0085 (9.4); -0.0107 (2.2); -0.0115 (1.9); - 0.0123 (1.7); -0.0132 (1.5); -0.0140 (1.4); -0.0148 (1.4); -0.0163 (1.2); -0.0171 (1.2); -0.0187 (1.0); - 0.0219 (0.9); -0.0322 (0.6); -0.0502 (1.9); -0.1200 (0.6); -0.1498 (0.9) I.3-11: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 16.1969 (1.7); 7.8949 (1.9); 7.5380 (4.4); 7.5344 (6.1); 7.5205 (5.2); 7.5186 (5.4); 7.5160 (6.7); 7.4871 (3.5); 7.4809 (3.5); 7.4700 (3.8); 7.4641 (5.0); 7.4570 (4.3); 7.4236 (3.7); 7.4097 (5.2); 7.4007 (5.0); 7.3854 (6.2); 7.3797 (6.5); 7.3668 (8.6); 7.3604 (7.8); 7.3577 (7.4); 7.3537 (5.1); 7.3483 (16.0); 7.3442 (9.3); 7.3397 (6.5); 7.3358 (8.7); 7.3305 (10.9); 7.3270 (11.5); 7.3225 (6.6); 7.3095 (6.0); 7.2986 (10.3); 7.2933 (10.4); 7.2896 (7.7); 7.2830 (9.2); 7.2756 (12.0); 7.2709 (5.4); 7.2627 (5.1); 7.2574 (9.6); 7.2528 (7.0); 7.2440 (5.8); 7.2401 (7.0); 7.2376 (6.5); 7.2344 (3.7); 7.2254 (4.7); 7.2200 (3.6); 7.2070 (1.8); 5.3133 (7.8); 4.1001 (3.0); 4.0566 (6.5); 4.0037 (6.4); 3.9598 (2.6); 3.7650 (13.2); 3.4143 (2.1); 3.4036 (4.3); 3.3954 (4.5); 3.3781 (4.9); 3.3669 (11.2); 3.3501 (3.2); 3.3459 (4.1); 3.3406 (17.1); 3.3128 (2813.9); 3.2941 (8.0); 3.2807 (4.9); 3.2783 (9.4); 3.2634 (15.8); 3.2220 (2.2); 3.2133 (2.5); 3.1936 (5.0); 2.6742 (8.2); 2.6695 (10.9); 2.6649 (7.7); 2.5231 (32.0); 2.5184 (45.3); 2.5097 (606.0); 2.5051 (1326.1); 2.5005 (1862.2); 2.4959 (1286.0); 2.4913 (559.9); 2.4656 (4.5); 2.4601 (6.9); 2.4552 (9.9); 2.4507 (11.9); 2.4461 (8.3); 2.4048 (2.8); 2.3320 (8.0); 2.3273 (11.8); 2.3226 (7.6); 2.0722 (2.2); 1.2361 (1.7); 1.1744 (5.2); 1.1566 (10.6); 1.1388 (4.7); 1.0458 (4.9); 1.0283 (10.2); 1.0106 (4.4); -0.0002 (37.3) I.3-12: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 9.2219 (6.0); 8.7998 (3.0); 8.7831 (3.1); 7.9455 (2.4); 7.6726 (11.5); 7.6698 (14.3); 7.6506 (16.0); 7.6481 (13.5); 7.6242 (4.5); 7.6212 (5.2); 7.6021 (5.8); 7.5995 (5.1); 7.5333 (11.0); 7.5117 (13.1); 7.4156 (4.8); 7.4074 (11.7); 7.4023 (4.5); 7.3972 (6.3); 7.3942 (5.9); 7.3889 (15.5); 7.3754 (4.8); 7.3721 (4.2); 7.3672 (11.9); 7.2928 (3.9); 7.2777 (3.3); 7.1904 (2.3); 7.1679 (6.8); 7.1494 (10.1); 7.1309 (4.5); 4.9216 (1.9); 4.8666 (1.7); 4.2616 (4.6); 4.2454 (5.4); 4.2356 (6.1); 4.2269 (2.8); 4.2195 (5.0); 4.2118 (2.3); 4.2004 (2.7); 4.1851 (2.6); 4.0002 (1.8); 3.9717 (1.4); 3.7942 (3.6); 3.7751 (3.3); 3.3090 (478.0); 3.2581 (2.1); 3.1898 (1.4); 3.0822 (2.3); 3.0642 (4.8); 3.0455 (4.2); 3.0395 (3.4); 3.0219 (6.6); 3.0027 (4.3); 2.7615 (1.7); 2.7536 (1.5); 2.6740 (5.4); 2.6695 (7.6); 2.6648 (5.6); 2.5634 (2.7); 2.5228 (21.4); 2.5182 (29.7); 2.5095 (441.1); 2.5049 (976.2); 2.5003 (1372.0); 2.4957 (956.4); 2.4911 (431.7); 2.4542 (2.7); 2.4496 (3.8); 2.4453 (3.7); 2.3318 (6.1); 2.3271 (8.6); 2.3225 (6.2); 1.9878 (1.8); 0.0080 (5.9); -0.0002 (224.2); -0.0085 (6.7) I.3-15: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.6226 (0.9); 8.6066 (0.9); 7.4931 (2.0); 7.4874 (2.2); 7.4676 (2.3); 7.4620 (1.8); 7.1686 (0.9); 7.1542 (1.8); 7.1479 (1.7); 7.1341 (1.4); 7.1289 (2.5); 7.1258 (2.4); 7.1180 (4.3); 7.1122 (3.2); 7.1025 (2.1); 7.0949 (1.9); 7.0879 (0.5); 7.0301 (0.7); 7.0125 (0.8); 7.0069 (1.3); 7.0012 (0.7); 6.9840 (0.7); 4.4297 (0.6); 4.4212 (0.6); 4.4113 (0.6); 4.4021 (0.5); 4.1361 (1.2); 4.1191 (1.3); 4.1100 (1.6); 4.0930 (1.2); 3.6489 (1.2); 3.6414 (1.1); 3.6232 (1.1); 3.6157 (1.0); 3.4362 (9.1); 3.3120 (63.5); 2.9956 (1.3); 2.9752 (1.3); 2.9525 (1.5); 2.9321 (1.4); 2.6741 (0.7); 2.6696 (1.0); 2.6649 (0.7); 2.5230 (3.2); 2.5182 (4.8); 2.5096 (58.8); 2.5051 (125.0); 2.5005 (172.4); 2.4959 (120.9); 2.4913 (53.9); 2.4567 (1.4); 2.4477 (1.3); 2.4135 (1.1); 2.4043 (1.1); 2.3319 (0.7); 2.3273 (1.0); 2.3226 (0.7); 2.2340 (16.0); -0.0002 (7.1) I.3-16: 1 H-NMR (400.0 MHz, CDCl 3 ): δ= 7.5176 (1.2); 7.3267 (0.9); 7.3227 (1.0); 7.3077 (1.9); 7.3034 (2.5); 7.2886 (2.2); 7.2840 (2.4); 7.2755 (2.6); 7.2588 (208.4); 7.2418 (3.4); 7.2370 (5.9); 7.2185 (1.9); 7.2117 (1.3); 7.2034 (0.8); 7.1959 (0.8); 7.1821 (2.2); 7.1759 (1.5); 7.1721 (1.6); 7.1656 (1.0); 7.1566 (1.7); 7.1526 (2.2); 7.1475 (1.4); 7.1332 (0.8); 7.1273 (1.0); 7.1207 (1.4); 7.1172 (1.0); 7.1002 (0.9); 7.0967 (0.8); 6.9948 (1.2); 5.5897 (0.6); 4.6966 (0.5); 4.6896 (0.7); 4.6805 (0.8); 4.6713 (0.7); 4.1086 (1.2); 4.0911 (1.2); 4.0822 (1.4); 4.0653 (1.3); 3.6136 (10.6); 3.5852 (1.3); 3.5763 (1.3); 3.5590 (1.2); 3.5503 (1.1); 2.9212 (1.6); 2.9013 (1.8); 2.8777 (1.9); 2.8578 (1.9); 2.3252 (1.6); 2.3146 (1.6); 2.2846 (16.0); 2.2718 (1.4); 1.5295 (26.4); 1.2593 (0.7); 0.0079 (3.0); -0.0002 (84.0); -0.0085 (2.7) I.3-17: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.5997 (1.4); 8.5826 (1.3); 7.8956 (3.2); 7.8899 (1.3); 7.8727 (9.8); 7.8497 (9.7); 7.8440 (1.9); 7.8325 (1.3); 7.8269 (3.0); 7.0134 (2.2); 6.9945 (3.3); 6.9509 (3.4); 6.9260 (2.2); 6.9067 (1.4); 5.7520 (3.1); 4.4371 (0.9); 4.1848 (1.6); 4.1680 (1.7); 4.1590 (1.9); 4.1425 (1.5); 3.6887 (1.5); 3.6811 (1.5); 3.6628 (1.3); 3.6555 (1.4); 3.3863 (11.0); 3.3036 (52.8); 3.0049 (1.6); 2.9847 (1.7); 2.9618 (1.9); 2.9416 (1.8); 2.6737 (1.3); 2.6688 (1.8); 2.6643 (1.3); 2.5224 (5.2); 2.5177 (7.4); 2.5090 (109.2); 2.5045 (231.4); 2.4999 (315.5); 2.4953 (220.4); 2.4908 (98.6); 2.4757 (2.4); 2.4667 (1.6); 2.4497 (0.6); 2.4328 (1.3); 2.4227 (1.4); 2.3313 (1.4); 2.3267 (1.9); 2.3224 (1.3); 2.1937 (15.6); 2.1699 (16.0); 0.1460 (0.6); 0.0080 (4.7); -0.0002 (153.6); -0.0085 (4.7); -0.1498 (0.7) I.3-20: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.6993 (1.5); 8.6829 (1.4); 7.5397 (5.7); 7.5349 (1.8); 7.5233 (2.1); 7.5184 (6.6); 7.4174 (2.0); 7.4107 (1.1); 7.4056 (2.1); 7.4017 (1.7); 7.3942 (2.7); 7.3654 (1.4); 7.3577 (1.2); 7.3539 (2.0); 7.3480 (1.3); 7.3418 (2.5); 7.2943 (1.1); 7.2829 (5.4); 7.2816 (4.8); 7.2760 (3.1); 7.2714 (3.3); 7.2697 (3.4); 7.2654 (2.5); 7.2591 (3.8); 7.1897 (4.7); 7.1693 (4.2); 5.7550 (1.5); 4.4295 (0.7); 4.4211 (0.8); 4.4100 (0.8); 4.4023 (0.8); 4.1276 (1.8); 4.1108 (2.0); 4.1020 (2.3); 4.0853 (1.7); 3.6258 (1.7); 3.6179 (1.7); 3.5998 (1.9); 3.5901 (13.1); 3.3523 (0.6); 3.3197 (510.1); 3.2856 (0.9); 3.2701 (5.6); 2.9309 (1.7); 2.9105 (1.8); 2.8882 (2.2); 2.8678 (1.9); 2.6746 (1.0); 2.6700 (1.4); 2.6652 (1.0); 2.5235 (3.0); 2.5188 (4.4); 2.5101 (73.5); 2.5055 (163.0); 2.5009 (229.4); 2.4963 (160.8); 2.4917 (71.5); 2.4608 (1.7); 2.4560 (2.5); 2.4514 (3.0); 2.4469 (2.0); 2.4208 (1.9); 2.4115 (2.0); 2.3779 (1.6); 2.3687 (1.7); 2.3323 (1.1); 2.3276 (1.5); 2.3231 (1.0); 2.2797 (16.0); 2.0731 (1.0); 1.9882 (1.2); 1.1744 (0.7); -0.0002 (2.2) I.3-21: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.5651 (2.4); 8.5488 (2.3); 7.4722 (6.8); 7.4661 (14.2); 7.4449 (11.1); 7.3701 (6.2); 7.3636 (5.4); 7.3488 (3.9); 7.3422 (3.6); 7.2551 (0.8); 7.2526 (0.7); 5.7541 (16.0); 4.5627 (0.6); 4.5107 (1.2); 4.4902 (2.3); 4.4701 (1.4); 4.4665 (1.3); 4.4466 (0.5); 4.3077 (0.6); 4.2990 (0.9); 4.2906 (1.2); 4.2812 (1.3); 4.2711 (1.2); 4.2629 (0.9); 4.2541 (0.6); 4.0384 (1.4); 4.0206 (1.4); 3.6977 (3.0); 3.6806 (3.2); 3.6723 (3.6); 3.6553 (3.0); 3.5947 (15.3); 3.3157 (59.2); 3.2474 (3.0); 3.2389 (3.0); 3.2220 (2.8); 3.2135 (2.7); 2.6485 (3.0); 2.6277 (3.4); 2.6063 (4.0); 2.5855 (3.5); 2.5238 (0.7); 2.5192 (1.1); 2.5105 (15.5); 2.5058 (34.1); 2.5012 (47.7); 2.4966 (33.2); 2.4920 (14.6); 2.1914 (0.5); 2.1803 (3.5); 2.1701 (4.9); 2.1422 (3.4); 2.1382 (5.3); 2.1278 (3.3); 2.1183 (2.5); 2.1142 (2.2); 2.0938 (0.8); 2.0895 (0.7); 2.0216 (0.6); 2.0188 (0.6); 2.0083 (1.3); 2.0063 (1.4); 1.9997 (1.6); 1.9962 (1.4); 1.9883 (8.8); 1.9809 (2.1); 1.9738 (1.9); 1.9706 (1.6); 1.9679 (1.7); 1.9626 (1.5); 1.9554 (1.6); 1.9368 (0.7); 1.6611 (0.8); 1.6521 (0.6); 1.6444 (2.4); 1.6362 (1.7); 1.6304 (2.1); 1.6198 (4.3); 1.6064 (2.5); 1.5952 (2.0); 1.5812 (0.8); 1.1927 (1.9); 1.1749 (4.0); 1.1571 (1.9); 0.0080 (1.0); -0.0002 (37.6); -0.0086 (1.0) I.3-22: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.6320 (0.9); 8.6150 (0.9); 7.6627 (2.8); 7.6598 (3.4); 7.6548 (0.9); 7.6406 (3.9); 7.6381 (3.3); 7.3951 (2.7); 7.3898 (0.9); 7.3766 (3.6); 7.3736 (2.8); 7.3597 (1.0); 7.3549 (2.8); 7.1715 (1.0); 7.1575 (2.8); 7.1500 (1.7); 7.1394 (3.1); 7.1311 (1.5); 7.1258 (2.6); 7.1232 (2.9); 7.1149 (4.3); 7.1091 (3.4); 7.0994 (2.2); 7.0919 (2.0); 7.0853 (0.6); 4.4234 (0.6); 4.4155 (0.6); 4.4046 (0.6); 4.3957 (0.5); 4.1549 (1.5); 4.1380 (1.5); 4.1292 (1.8); 4.1125 (1.4); 3.6362 (1.2); 3.6284 (1.2); 3.6108 (1.2); 3.6029 (1.2); 3.4434 (9.1); 3.3116 (40.7); 2.9446 (1.4); 2.9243 (1.4); 2.9019 (1.7); 2.8816 (1.5); 2.6692 (0.7); 2.5227 (2.0); 2.5180 (2.8); 2.5094 (37.9); 2.5048 (81.5); 2.5002 (113.2); 2.4956 (79.1); 2.4910 (35.5); 2.4265 (1.3); 2.4174 (1.3); 2.3839 (1.2); 2.3745 (1.1); 2.3271 (0.6); 2.2346 (16.0); -0.0002 (16.3) I.3-23: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.5308 (1.5); 8.5151 (1.5); 7.4204 (2.4); 7.4145 (1.4); 7.4077 (2.7); 7.4043 (2.2); 7.3973 (3.3); 7.3886 (0.5); 7.3544 (1.6); 7.3478 (1.5); 7.3444 (2.1); 7.3429 (1.5); 7.3372 (1.7); 7.3316 (3.1); 7.2981 (1.4); 7.2920 (0.6); 7.2863 (6.4); 7.2838 (5.4); 7.2798 (4.0); 7.2732 (6.2); 7.2671 (2.9); 7.2627 (3.5); 7.2607 (3.3); 7.2487 (0.6); 4.2971 (0.6); 4.2897 (0.9); 4.2800 (1.0); 4.2707 (0.9); 4.2640 (0.6); 3.6085 (2.6); 3.5912 (2.7); 3.5829 (3.3); 3.5704 (10.0); 3.3135 (202.8); 3.2638 (1.2); 3.1601 (2.4); 3.1511 (2.4); 3.1346 (2.2); 3.1257 (2.2); 3.0381 (1.0); 3.0189 (1.1); 3.0049 (2.6); 2.9860 (2.7); 2.9661 (2.4); 2.9478 (2.5); 2.9329 (1.0); 2.9147 (1.0); 2.6743 (0.6); 2.6697 (0.8); 2.6650 (0.6); 2.6498 (1.6); 2.6288 (1.7); 2.6076 (2.1); 2.5868 (1.9); 2.5231 (2.0); 2.5184 (2.8); 2.5097 (40.4); 2.5051 (89.6); 2.5005 (126.3); 2.4959 (87.2); 2.4913 (38.1); 2.4550 (0.6); 2.4505 (0.9); 2.4458 (0.6); 2.3319 (0.5); 2.3273 (0.8); 2.3226 (0.6); 2.2163 (2.1); 2.2057 (2.1); 2.1742 (1.8); 2.1636 (1.7); 1.8591 (0.6); 1.8412 (1.2); 1.8244 (1.6); 1.8076 (1.3); 1.7901 (0.6); 0.8324 (15.6); 0.8247 (16.0); 0.8158 (15.5); 0.8081 (15.2); -0.0002 (3.0) I.3-24: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.5915 (1.3); 8.5754 (1.3); 7.5039 (0.6); 7.4922 (2.8); 7.4865 (3.2); 7.4667 (3.2); 7.4611 (2.6); 7.0346 (0.6); 7.0287 (1.0); 7.0175 (2.4); 7.0117 (1.4); 7.0057 (2.2); 6.9990 (4.0); 6.9887 (0.7); 6.9827 (1.1); 6.9771 (0.5); 6.9555 (3.3); 6.9293 (2.1); 6.9108 (1.3); 5.7537 (0.6); 4.4321 (0.6); 4.4235 (0.8); 4.4155 (0.8); 4.4044 (0.8); 4.3956 (0.7); 4.1318 (1.8); 4.1150 (1.8); 4.1057 (2.2); 4.0890 (1.7); 3.6498 (1.6); 3.6421 (1.6); 3.6236 (1.5); 3.6163 (1.4); 3.3868 (11.2); 3.3110 (50.7); 2.9957 (1.8); 2.9754 (1.9); 2.9525 (2.2); 2.9322 (1.9); 2.6741 (0.6); 2.6695 (0.8); 2.6649 (0.6); 2.5230 (2.6); 2.5183 (3.8); 2.5096 (46.4); 2.5050 (99.6); 2.5004 (137.5); 2.4958 (95.7); 2.4912 (42.4); 2.4565 (1.9); 2.4476 (1.8); 2.4134 (1.5); 2.4045 (1.5); 2.3318 (0.7); 2.3272 (0.8); 2.3226 (0.6); 2.2013 (15.5); 2.1761 (16.0); -0.0002 (6.2) I.3-25: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.5923 (1.3); 8.5774 (1.3); 7.6929 (3.8); 7.6871 (1.3); 7.6806 (4.0); 7.6752 (2.0); 7.6697 (4.3); 7.6633 (1.3); 7.6574 (4.0); 7.2376 (4.2); 7.2318 (1.2); 7.2201 (1.4); 7.2156 (5.7); 7.2104 (1.3); 7.1987 (1.1); 7.1929 (3.7); 7.0151 (2.2); 6.9961 (3.3); 6.9578 (3.3); 6.9272 (2.0); 6.9085 (1.3); 5.7536 (1.0); 4.4229 (0.7); 4.4140 (0.8); 4.4056 (0.8); 4.3946 (0.8); 4.3864 (0.7); 4.1421 (1.9); 4.1254 (2.0); 4.1166 (2.4); 4.1000 (1.9); 3.6188 (1.7); 3.6112 (1.7); 3.5935 (1.5); 3.5858 (1.5); 3.3921 (11.3); 3.3102 (103.6); 3.0898 (0.6); 2.9339 (1.8); 2.9137 (2.0); 2.8911 (2.2); 2.8709 (2.0); 2.6740 (1.0); 2.6694 (1.4); 2.6647 (1.0); 2.5229 (3.7); 2.5182 (5.5); 2.5095 (80.6); 2.5049 (175.8); 2.5003 (246.2); 2.4957 (173.4); 2.4910 (77.6); 2.4183 (1.9); 2.4089 (1.9); 2.3756 (1.6); 2.3664 (1.5); 2.3317 (1.1); 2.3270 (1.5); 2.3225 (1.0); 2.2650 (0.5); 2.1986 (15.5); 2.1754 (16.0); 0.0080 (1.1); -0.0002 (36.0); -0.0085 (0.9) I.3-26: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.6014 (1.3); 8.5859 (1.3); 7.6619 (4.0); 7.6591 (4.9); 7.6540 (1.3); 7.6399 (5.5); 7.6374 (4.6); 7.3945 (4.0); 7.3893 (1.2); 7.3760 (5.0); 7.3730 (3.9); 7.3590 (1.3); 7.3543 (3.9); 7.1595 (1.2); 7.1567 (2.0); 7.1541 (1.1); 7.1383 (3.3); 7.1226 (0.9); 7.1199 (1.4); 7.0144 (2.2); 6.9952 (3.4); 6.9593 (3.2); 6.9263 (2.1); 6.9070 (1.4); 5.7535 (1.2); 4.4255 (0.7); 4.4168 (0.8); 4.4093 (0.9); 4.3988 (0.9); 4.3899 (0.7); 4.1514 (2.0); 4.1347 (2.0); 4.1258 (2.5); 4.1091 (1.9); 3.6379 (1.7); 3.6302 (1.7); 3.6122 (1.6); 3.6048 (1.5); 3.3938 (11.4); 3.3112 (73.0); 3.3103 (66.3); 2.9440 (1.9); 2.9238 (2.0); 2.9013 (2.4); 2.8810 (2.1); 2.6739 (0.8); 2.6693 (1.1); 2.6646 (0.8); 2.5227 (3.2); 2.5180 (4.5); 2.5094 (61.1); 2.5048 (131.8); 2.5002 (183.1); 2.4956 (126.9); 2.4910 (56.1); 2.4269 (1.8); 2.4178 (1.7); 2.3844 (1.6); 2.3752 (1.6); 2.3316 (0.9); 2.3270 (1.0); 2.3223 (0.7); 2.1965 (15.6); 2.1762 (16.0); 0.0080 (0.5); -0.0002 (19.0); -0.0085 (0.6) I.3-27: 1 H-NMR (400.0 MHz, CDCl 3 ): δ= 7.4922 (2.9); 7.4865 (1.0); 7.4804 (3.0); 7.4748 (1.8); 7.4692 (3.2); 7.4631 (1.0); 7.4573 (3.2); 7.2599 (44.0); 7.2513 (0.6); 7.2423 (0.7); 7.2389 (1.6); 7.2277 (2.5); 7.2232 (3.6); 7.2187 (3.7); 7.2018 (1.9); 7.1957 (1.3); 7.1854 (0.7); 7.1798 (0.9); 7.1762 (0.6); 7.1714 (1.4); 7.1680 (2.2); 7.1551 (0.5); 7.1511 (0.8); 7.0636 (3.4); 7.0578 (1.0); 7.0462 (1.2); 7.0431 (3.8); 7.0407 (3.3); 7.0374 (1.1); 7.0258 (1.0); 7.0201 (2.9); 5.6218 (0.6); 5.6064 (0.6); 4.6364 (0.7); 4.6322 (0.5); 4.6271 (0.8); 4.6222 (0.5); 4.6177 (0.6); 4.1642 (1.9); 4.1472 (1.9); 4.1382 (2.2); 4.1213 (1.9); 3.6182 (1.7); 3.6083 (1.9); 3.5988 (11.0); 3.5925 (2.0); 3.5826 (1.5); 2.9540 (1.7); 2.9331 (1.7); 2.9104 (2.0); 2.8896 (1.9); 2.6082 (1.0); 2.3496 (1.6); 2.3376 (1.6); 2.3061 (1.4); 2.2941 (1.5); 2.2682 (16.0); 1.5644 (6.0); 0.0080 (0.5); -0.0002 (16.4); -0.0085 (0.5) I.3-28: 1 H-NMR (400.0 MHz, CDCl 3 ): δ= 7.5180 (0.8); 7.3285 (1.0); 7.3245 (1.4); 7.3098 (2.2); 7.3052 (3.0); 7.2900 (2.2); 7.2856 (2.5); 7.2770 (1.7); 7.2705 (2.4); 7.2591 (129.0); 7.2504 (2.2); 7.2459 (1.3); 7.2378 (1.2); 7.2333 (0.9); 7.1764 (1.5); 7.1728 (1.9); 7.1575 (2.1); 7.1536 (3.1); 7.1485 (1.9); 7.1383 (1.0); 7.1343 (1.2); 7.1284 (1.5); 7.1216 (3.1); 7.1188 (3.0); 7.1011 (4.6); 7.0598 (2.2); 7.0401 (1.2); 6.9951 (1.0); 6.9859 (3.2); 5.6369 (0.9); 5.6196 (0.8); 4.6970 (0.7); 4.6897 (0.9); 4.6803 (1.0); 4.6720 (0.9); 4.6628 (0.7); 4.1062 (1.6); 4.0902 (1.6); 4.0799 (1.8); 4.0652 (1.6); 3.5918 (1.8); 3.5828 (1.9); 3.5671 (14.0); 3.5569 (1.8); 2.9204 (2.2); 2.9004 (2.3); 2.8769 (2.6); 2.8571 (2.4); 2.3305 (3.0); 2.3233 (15.8); 2.2873 (1.8); 2.2771 (1.8); 2.2274 (16.0); 1.5369 (8.9); 1.2586 (1.0); 0.0080 (1.9); -0.0002 (53.9); -0.0085 (1.8) I.3-29: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.5421 (1.2); 8.5264 (1.2); 7.4666 (4.1); 7.4625 (5.5); 7.4603 (4.9); 7.4413 (6.5); 7.3672 (3.5); 7.3607 (3.0); 7.3458 (2.2); 7.3393 (2.0); 5.7527 (0.6); 4.2858 (0.5); 4.2785 (0.8); 4.2689 (0.8); 4.2587 (0.8); 4.2492 (0.5); 4.1922 (0.6); 4.1753 (1.5); 4.1583 (2.1); 4.1414 (1.5); 4.1244 (0.6); 3.5909 (9.5); 3.5557 (1.9); 3.5388 (2.0); 3.5304 (2.3); 3.5135 (2.0); 3.3055 (21.0); 3.0869 (1.9); 3.0782 (1.9); 3.0616 (1.7); 3.0529 (1.7); 2.6694 (0.6); 2.6249 (1.9); 2.6040 (2.1); 2.5828 (2.5); 2.5621 (2.2); 2.5228 (1.9); 2.5181 (2.7); 2.5094 (35.9); 2.5049 (77.7); 2.5002 (108.3); 2.4956 (75.4); 2.4911 (34.1); 2.3270 (0.6); 2.1750 (2.1); 2.1645 (2.0); 2.1330 (1.7); 2.1225 (1.7); 1.0628 (12.1); 1.0454 (16.0); 1.0268 (11.7); 0.0080 (1.8); -0.0002 (63.1); -0.0085 (1.9) I.3-30: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.5935 (1.5); 8.5783 (1.5); 8.1378 (3.2); 8.1348 (3.4); 8.0274 (1.3); 8.0213 (1.3); 8.0121 (2.0); 8.0038 (1.5); 7.9980 (1.2); 7.6036 (6.2); 7.6016 (5.9); 7.5954 (2.8); 7.5919 (2.8); 7.5876 (3.4); 7.0164 (2.3); 6.9976 (3.4); 6.9563 (3.4); 6.9280 (2.2); 6.9093 (1.4); 5.7530 (5.6); 4.4386 (1.0); 4.1782 (1.6); 4.1615 (1.6); 4.1523 (2.0); 4.1356 (1.6); 3.6829 (1.6); 3.6750 (1.7); 3.6569 (1.5); 3.6495 (1.4); 3.4284 (0.9); 3.3904 (11.5); 3.3082 (241.4); 3.2579 (1.0); 2.9852 (1.6); 2.9651 (1.8); 2.9423 (2.0); 2.9221 (1.8); 2.6737 (2.4); 2.6693 (3.2); 2.6647 (2.5); 2.6202 (1.6); 2.5226 (18.7); 2.5179 (22.7); 2.5092 (177.7); 2.5047 (368.5); 2.5001 (509.9); 2.4956 (368.9); 2.4911 (175.8); 2.4637 (2.4); 2.4542 (2.9); 2.4491 (2.2); 2.4445 (2.4); 2.4208 (1.8); 2.4116 (1.8); 2.3316 (2.3); 2.3270 (3.0); 2.3223 (2.3); 2.1974 (15.8); 2.1765 (16.0); 1.9877 (0.7); 1.2415 (1.3); 0.8547 (0.7); -0.0002 (18.4) I.3-31: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.7210 (0.9); 8.7046 (0.8); 7.5549 (3.3); 7.5493 (1.0); 7.5377 (1.2); 7.5321 (3.6); 7.4809 (2.0); 7.4744 (2.2); 7.4597 (1.9); 7.4383 (3.0); 7.3668 (1.6); 7.3603 (1.4); 7.3454 (1.0); 7.3389 (0.9); 6.9535 (3.6); 6.9479 (1.0); 6.9362 (1.0); 6.9307 (3.2); 4.1172 (0.8); 4.1004 (0.9); 4.0916 (1.0); 4.0750 (0.8); 3.7424 (16.0); 3.6137 (5.5); 3.6011 (1.0); 3.5933 (0.9); 3.5754 (0.8); 3.5679 (0.8); 3.3172 (54.3); 2.9145 (0.8); 2.8941 (0.8); 2.8719 (1.0); 2.8515 (0.9); 2.5472 (0.5); 2.5232 (1.8); 2.5100 (18.9); 2.5055 (38.1); 2.5010 (51.1); 2.4964 (35.8); 2.4919 (16.4); 2.4559 (0.6); 2.4514 (0.6); 2.3978 (0.9); 2.3887 (0.9); 2.3553 (0.8); 2.3462 (0.8); 1.9884 (0.5); 0.0080 (0.7); -0.0002 (19.4); -0.0086 (0.8) I.3-32: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.4034 (1.2); 8.3877 (1.1); 7.0188 (2.2); 6.9998 (3.3); 6.9604 (3.3); 6.9321 (2.1); 6.9128 (1.3); 5.7520 (1.4); 4.2761 (0.6); 4.2688 (0.8); 4.2592 (1.0); 4.2493 (0.8); 4.2423 (0.6); 4.1875 (0.6); 4.1705 (1.6); 4.1536 (2.2); 4.1366 (1.6); 4.1196 (0.6); 3.5464 (2.0); 3.5295 (2.2); 3.5212 (2.4); 3.5043 (2.1); 3.4169 (0.7); 3.3798 (5.3); 3.3702 (5.4); 3.3332 (0.8); 3.3053 (27.6); 3.0572 (2.0); 3.0483 (2.0); 3.0320 (1.8); 3.0231 (1.8); 2.6117 (2.1); 2.5909 (2.2); 2.5698 (2.7); 2.5490 (2.3); 2.5223 (1.4); 2.5176 (1.9); 2.5090 (28.1); 2.5044 (62.0); 2.4998 (87.1); 2.4952 (61.0); 2.4906 (27.8); 2.4500 (0.5); 2.3265 (0.5); 2.2221 (15.4); 2.1819 (16.0); 2.1693 (2.5); 2.1585 (2.3); 2.1274 (1.8); 2.1166 (1.9); 1.0487 (12.9); 1.0393 (13.0); 1.0318 (13.3); 1.0224 (12.7); -0.0002 (13.2) I.3-33: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.4331 (0.8); 8.4172 (0.8); 7.1643 (0.8); 7.1510 (1.8); 7.1424 (2.0); 7.1342 (1.3); 7.1283 (2.7); 7.1259 (2.4); 7.1180 (4.5); 7.1128 (3.3); 7.1036 (2.1); 7.0971 (1.2); 7.0947 (1.0); 7.0913 (0.6); 4.2730 (0.6); 4.2633 (0.7); 4.2534 (0.6); 4.1701 (1.1); 4.1531 (1.5); 4.1361 (1.1); 3.5496 (1.4); 3.5326 (1.5); 3.5244 (1.7); 3.5074 (1.5); 3.4270 (4.3); 3.4194 (4.4); 3.3065 (35.2); 3.0606 (1.4); 3.0515 (1.4); 3.0354 (1.3); 3.0264 (1.3); 2.6123 (1.4); 2.5914 (1.5); 2.5703 (1.9); 2.5495 (1.5); 2.5225 (1.1); 2.5178 (1.6); 2.5091 (23.8); 2.5045 (51.4); 2.4999 (71.8); 2.4953 (50.5); 2.4907 (22.9); 2.2377 (16.0); 2.1693 (1.6); 2.1583 (1.6); 2.1274 (1.3); 2.1164 (1.3); 1.0500 (9.0); 1.0396 (9.2); 1.0331 (9.4); 1.0227 (8.8) I.3-34: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.5210 (11.0); 7.4573 (15.5); 7.4291 (11.2); 7.4162 (9.6); 7.3973 (8.9); 5.3584 (9.7); 5.3277 (7.9); 4.0832 (10.1); 3.4321 (8.6); 3.3112 (4874.4); 3.2610 (55.6); 3.2210 (8.2); 2.6695 (32.5); 2.5094 (2043.6); 2.5050 (3959.1); 2.5005 (5216.0); 2.4959 (3820.1); 2.4915 (1932.9); 2.4552 (70.8); 2.4505 (77.9); 2.4458 (57.7); 2.4099 (21.6); 2.3272 (35.9); 1.0554 (7.3); 0.8201 (11.8); 0.8035 (16.0); 0.7754 (12.8); 0.6877 (11.8); 0.6713 (10.2); 0.0079 (36.9); -0.0002 (893.7); -0.0504 (14.4) I.3-35: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.5374 (1.8); 8.5211 (1.8); 7.4252 (2.6); 7.4197 (1.6); 7.4145 (1.5); 7.4119 (2.4); 7.4088 (2.3); 7.4021 (3.6); 7.3932 (0.6); 7.3603 (1.8); 7.3535 (1.5); 7.3504 (2.1); 7.3478 (1.6); 7.3425 (1.9); 7.3371 (3.4); 7.3089 (0.5); 7.3027 (1.5); 7.2957 (0.6); 7.2905 (6.3); 7.2874 (5.6); 7.2843 (4.3); 7.2771 (8.5); 7.2703 (3.2); 7.2671 (3.6); 7.2641 (3.2); 7.2520 (0.7); 5.7538 (1.1); 4.5330 (0.7); 4.5144 (1.0); 4.4909 (1.9); 4.4708 (1.1); 4.4673 (1.0); 4.3030 (0.7); 4.2950 (1.0); 4.2855 (1.1); 4.2757 (1.0); 4.2678 (0.7); 4.0559 (1.0); 4.0381 (3.1); 4.0203 (3.1); 4.0025 (1.0); 3.6988 (2.4); 3.6816 (2.6); 3.6735 (3.0); 3.6563 (2.5); 3.6166 (0.8); 3.5780 (8.1); 3.5706 (8.2); 3.5320 (0.8); 3.3154 (55.5); 3.2555 (2.5); 3.2468 (2.5); 3.2301 (2.2); 3.2215 (2.2); 2.6448 (2.5); 2.6239 (2.8); 2.6025 (3.3); 2.5817 (2.9); 2.5231 (0.7); 2.5184 (1.0); 2.5097 (12.8); 2.5051 (28.0); 2.5005 (39.1); 2.4959 (27.1); 2.4913 (11.9); 2.1953 (0.6); 2.1880 (3.0); 2.1775 (3.1); 2.1705 (1.9); 2.1457 (5.1); 2.1354 (2.7); 2.1269 (1.0); 2.1195 (2.4); 2.0951 (0.8); 2.0193 (0.5); 2.0168 (0.5); 2.0063 (1.0); 2.0040 (1.1); 1.9990 (1.4); 1.9879 (16.0); 1.9837 (1.7); 1.9786 (1.7); 1.9727 (1.6); 1.9694 (1.4); 1.9662 (1.4); 1.9625 (1.2); 1.9586 (1.1); 1.9541 (1.2); 1.9463 (0.6); 1.9364 (0.6); 1.6607 (0.7); 1.6442 (2.0); 1.6358 (1.4); 1.6306 (1.8); 1.6198 (3.6); 1.6064 (2.0); 1.5952 (1.6); 1.5808 (0.6); 1.1922 (4.5); 1.1744 (8.9); 1.1566 (4.4); 0.0079 (0.8); -0.0002 (25.7); -0.0027 (1.1); -0.0085 (0.7) I.3-36: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 15.5677 (2.2); 15.5575 (1.9); 8.9875 (0.7); 8.9712 (0.6); 8.9426 (0.6); 8.9267 (0.6); 7.5529 (1.2); 7.5496 (1.4); 7.5343 (1.5); 7.5330 (1.6); 7.5306 (1.8); 7.4965 (0.8); 7.4905 (1.3); 7.4846 (1.3); 7.4802 (1.0); 7.4775 (0.8); 7.4738 (1.4); 7.4672 (1.1); 7.4565 (0.8); 7.4496 (0.6); 7.4446 (1.1); 7.4378 (1.5); 7.4320 (2.2); 7.4244 (1.4); 7.4217 (1.8); 7.4141 (2.0); 7.4085 (1.9); 7.3978 (0.8); 7.3946 (0.9); 7.3919 (0.9); 7.3890 (1.1); 7.3860 (0.8); 7.3832 (0.8); 7.3794 (0.7); 7.3772 (0.9); 7.3714 (1.2); 7.3645 (3.4); 7.3613 (2.7); 7.3589 (2.2); 7.3534 (2.6); 7.3512 (3.6); 7.3470 (3.0); 7.3411 (3.6); 7.3373 (3.2); 7.3316 (1.9); 7.3228 (0.9); 7.3180 (0.8); 7.3093 (1.9); 7.3030 (2.2); 7.3002 (2.5); 7.2941 (3.1); 7.2860 (4.4); 7.2797 (3.9); 7.2763 (2.6); 7.2697 (2.4); 7.2617 (1.0); 7.2572 (2.6); 7.2527 (2.1); 7.2464 (1.9); 7.2398 (2.3); 7.2341 (1.0); 7.2282 (1.4); 7.2224 (1.0); 7.2100 (0.5); 7.2043 (0.7); 7.1828 (0.6); 7.1743 (0.6); 7.1548 (0.5); 5.7541 (3.4); 5.2951 (2.9); 5.2706 (2.6); 4.4848 (0.6); 4.4563 (0.7); 4.4393 (0.6); 4.3554 (0.5); 4.3476 (0.5); 4.0915 (1.1); 4.0559 (1.2); 4.0480 (2.3); 4.0381 (3.4); 4.0203 (3.4); 4.0025 (1.1); 3.9833 (3.4); 3.9397 (1.6); 3.7665 (0.6); 3.7496 (0.6); 3.7408 (0.8); 3.7240 (0.6); 3.7167 (0.6); 3.7070 (0.6); 3.6966 (0.8); 3.6916 (1.0); 3.6810 (0.9); 3.6757 (0.7); 3.6651 (0.6); 3.3649 (1.2); 3.3584 (1.6); 3.3416 (2.4); 3.3324 (0.9); 3.3238 (1.2); 3.3133 (122.9); 3.2632 (1.0); 3.2494 (0.6); 3.2421 (0.5); 3.2162 (0.5); 3.1871 (0.6); 3.1728 (0.7); 3.1628 (0.6); 3.1575 (0.5); 3.1493 (0.7); 2.6974 (0.6); 2.6817 (0.7); 2.6769 (0.8); 2.6696 (0.7); 2.6649 (0.5); 2.6609 (0.9); 2.6550 (0.7); 2.6393 (0.8); 2.6346 (0.7); 2.6186 (0.7); 2.5231 (1.8); 2.5184 (2.8); 2.5097 (33.9); 2.5051 (74.6); 2.5005 (104.4); 2.4959 (73.1); 2.4913 (32.3); 2.4766 (1.0); 2.4710 (0.7); 2.4515 (1.6); 2.4456 (0.9); 2.4288 (0.7); 2.3273 (0.7); 2.3226 (0.5); 2.3153 (0.7); 2.2997 (0.7); 2.2855 (0.6); 2.2730 (0.5); 2.2688 (0.6); 2.1867 (1.2); 2.1777 (0.8); 2.1616 (1.3); 2.1443 (1.4); 2.1366 (1.8); 2.1131 (1.5); 2.1035 (1.0); 2.0921 (0.7); 2.0709 (1.0); 2.0613 (0.9); 1.9879 (16.0); 1.9685 (0.9); 1.9535 (1.0); 1.9379 (1.1); 1.9292 (0.9); 1.9106 (0.7); 1.6416 (0.6); 1.6257 (1.0); 1.6176 (1.5); 1.6090 (1.4); 1.6005 (1.6); 1.5947 (1.6); 1.5851 (1.4); 1.5609 (0.5); 1.2357 (0.6); 1.1922 (4.7); 1.1745 (9.6); 1.1567 (4.7); 0.0080 (2.0); 0.0063 (0.6); 0.0054 (0.6); 0.0046 (0.8); -0.0002 (70.4); -0.0052 (0.9); -0.0060 (0.7); -0.0068 (0.6); -0.0085 (2.0) I.3-37: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 7.5319 (6.8); 7.5109 (8.2); 7.4195 (8.0); 7.3799 (15.1); 7.3588 (16.0); 7.1665 (7.6); 7.1444 (5.5); 3.6619 (9.0); 3.3128 (232.5); 2.6695 (5.7); 2.5093 (399.5); 2.5048 (844.3); 2.5002 (1177.8); 2.4955 (845.7); 2.4910 (391.1); 2.4501 (5.9); 2.3270 (6.2); 0.0079 (12.6); -0.0002 (396.5); -0.0085 (14.3) I.4-11: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.0560 (3.6); 8.0504 (3.6); 7.7346 (9.3); 7.7290 (2.3); 7.7174 (2.2); 7.7118 (8.1); 7.7037 (0.7); 7.4571 (0.8); 7.4491 (8.4); 7.4436 (2.2); 7.4319 (2.0); 7.4264 (7.1); 7.4183 (0.6); 7.3082 (1.8); 7.2917 (1.8); 7.1445 (2.4); 7.1430 (2.3); 7.1242 (2.7); 7.1227 (2.7); 6.9179 (2.4); 6.9121 (2.3); 6.8977 (2.0); 6.8920 (2.0); 4.4047 (0.5); 4.3974 (0.7); 4.3884 (0.8); 4.3795 (0.7); 4.3720 (0.6); 4.1695 (1.6); 4.1535 (1.6); 4.1440 (2.0); 4.1281 (1.5); 3.6956 (1.4); 3.6872 (1.3); 3.6701 (1.3); 3.6621 (1.2); 3.3655 (0.6); 3.3152 (123.1); 3.0031 (1.6); 2.9837 (1.7); 2.9606 (2.0); 2.9412 (1.7); 2.5236 (1.3); 2.5189 (1.8); 2.5102 (24.7); 2.5056 (53.8); 2.5010 (75.4); 2.4964 (52.3); 2.4918 (22.8); 2.4449 (1.6); 2.4348 (1.5); 2.4024 (1.4); 2.3924 (1.3); 2.1383 (16.0); 2.0728 (0.8); 0.0080 (1.2); -0.0002 (42.8); -0.0085 (1.2) I.4-12: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.9179 (0.8); 8.5518 (4.1); 7.6652 (5.1); 7.6457 (6.3); 7.4692 (1.0); 7.4565 (1.1); 7.4462 (1.2); 7.4342 (1.1); 7.4105 (3.6); 7.3943 (6.0); 7.3887 (5.0); 7.3757 (9.6); 7.3545 (3.7); 7.1548 (2.0); 7.1364 (3.4); 7.1179 (1.9); 7.1095 (1.9); 7.0868 (1.3); 7.0779 (3.9); 7.0559 (6.9); 7.0337 (3.3); 6.8158 (2.2); 6.7993 (2.4); 4.3877 (1.3); 4.3789 (1.2); 4.1531 (2.0); 4.1362 (2.1); 4.1276 (2.4); 4.1111 (2.0); 3.6928 (2.0); 3.6833 (2.0); 3.6674 (1.9); 3.6579 (2.4); 3.3175 (18.7); 3.0806 (3.0); 3.0625 (3.0); 2.9439 (1.8); 2.9239 (2.0); 2.9014 (2.3); 2.8819 (2.1); 2.5059 (44.0); 2.5016 (56.3); 2.4977 (40.0); 2.4714 (3.0); 2.4599 (2.7); 2.4286 (1.9); 2.4174 (1.8); 2.0730 (1.6); 1.2056 (7.9); 1.1873 (16.0); 1.1692 (7.7); -0.0002 (2.4) I.4-21: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.1638 (4.0); 8.1600 (3.9); 8.1430 (4.3); 8.1391 (4.0); 7.9748 (6.0); 7.7398 (1.5); 7.7317 (11.6); 7.7261 (3.4); 7.7144 (3.9); 7.7089 (13.3); 7.7010 (1.1); 7.6234 (2.9); 7.6075 (2.8); 7.4580 (1.7); 7.4500 (14.2); 7.4445 (3.8); 7.4328 (3.5); 7.4273 (11.5); 7.4192 (1.2); 7.4089 (4.2); 7.4053 (4.5); 7.3890 (4.8); 7.3852 (4.6); 7.2660 (2.1); 7.2622 (2.0); 7.2445 (3.3); 7.2266 (2.2); 7.2230 (2.0); 6.9840 (3.3); 6.9800 (3.0); 6.9655 (3.5); 6.9616 (3.3); 6.9456 (2.6); 6.9416 (2.3); 4.4015 (1.4); 4.3923 (1.5); 4.1720 (2.6); 4.1560 (2.8); 4.1465 (3.4); 4.1306 (2.5); 4.0559 (0.9); 4.0381 (2.4); 4.0204 (2.2); 4.0024 (0.8); 3.6926 (2.3); 3.6854 (2.3); 3.6677 (2.3); 3.6594 (2.2); 3.3751 (3.5); 3.3275 (386.4); 3.2762 (5.1); 3.2238 (0.6); 3.1127 (0.9); 3.1008 (1.0); 3.0944 (1.0); 3.0825 (1.0); 3.0040 (2.7); 2.9848 (3.0); 2.9615 (3.4); 2.9420 (3.0); 2.6745 (2.5); 2.6699 (3.4); 2.6652 (2.4); 2.5465 (3.6); 2.5234 (9.1); 2.5187 (13.2); 2.5100 (188.1); 2.5054 (411.0); 2.5008 (576.8); 2.4961 (404.4); 2.4915 (180.2); 2.4599 (2.7); 2.4553 (5.1); 2.4505 (7.5); 2.4460 (6.3); 2.4357 (3.9); 2.4259 (3.0); 2.3928 (2.8); 2.3832 (2.6); 2.3323 (2.6); 2.3275 (3.4); 2.3229 (2.5); 2.0725 (11.7); 1.9880 (10.9); 1.9081 (16.0); 1.1956 (1.8); 1.1923 (3.4); 1.1773 (4.0); 1.1746 (6.8); 1.1568 (3.4); 0.1463 (0.7); 0.0080 (6.5); 0.0056 (1.5); -0.0002 (237.8); -0.0085 (7.6); -0.0504 (2.2); -0.1496 (0.8) I.4-29: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.1683 (2.5); 8.1645 (2.6); 8.1475 (2.8); 8.1436 (2.6); 7.9763 (3.8); 7.6271 (1.9); 7.6108 (1.9); 7.5661 (0.7); 7.5594 (5.8); 7.5546 (1.8); 7.5429 (1.9); 7.5380 (6.6); 7.5315 (0.6); 7.4074 (2.9); 7.4038 (2.9); 7.3874 (3.2); 7.3837 (3.0); 7.2646 (1.3); 7.2609 (1.2); 7.2460 (1.8); 7.2431 (2.2); 7.2254 (1.5); 7.2216 (1.4); 7.1965 (4.4); 7.1951 (4.8); 7.1747 (4.3); 7.1732 (3.7); 6.9813 (2.0); 6.9774 (2.1); 6.9629 (2.2); 6.9614 (2.2); 6.9590 (2.2); 6.9575 (2.2); 6.9430 (1.8); 6.9390 (1.6); 4.3940 (0.6); 4.3859 (0.8); 4.3777 (0.9); 4.3679 (0.8); 4.3603 (0.6); 4.1538 (1.9); 4.1379 (1.9); 4.1281 (2.3); 4.1124 (1.7); 3.6603 (1.6); 3.6524 (1.5); 3.6347 (1.5); 3.6268 (1.4); 3.3799 (0.8); 3.3311 (66.4); 3.2805 (1.2); 3.1108 (0.5); 3.0987 (0.5); 3.0925 (0.6); 3.0806 (0.6); 2.9767 (1.8); 2.9575 (1.9); 2.9344 (2.2); 2.9152 (1.9); 2.6746 (0.6); 2.6700 (0.8); 2.6653 (0.6); 2.5556 (0.8); 2.5513 (1.0); 2.5466 (0.8); 2.5235 (2.2); 2.5188 (3.1); 2.5101 (43.8); 2.5055 (96.0); 2.5009 (135.3); 2.4963 (93.9); 2.4917 (41.2); 2.4600 (0.8); 2.4556 (1.4); 2.4510 (1.8); 2.4464 (1.3); 2.4004 (1.9); 2.3908 (1.8); 2.3579 (1.5); 2.3484 (1.5); 2.3324 (0.7); 2.3277 (0.9); 2.3230 (0.7); 2.2801 (16.0); 1.9880 (0.6); 1.9084 (13.6); 1.1964 (1.0); 1.1782 (2.1); 1.1747 (0.6); 1.1600 (1.0); 0.0080 (0.7); -0.0002 (25.0); -0.0085 (0.7) I.4-30: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.1120 (0.5); 8.1067 (0.5); 8.0643 (3.5); 8.0586 (3.4); 7.8610 (3.5); 7.7410 (0.6); 7.7200 (0.5); 7.7172 (0.6); 7.6915 (3.5); 7.6886 (4.4); 7.6835 (1.1); 7.6695 (4.8); 7.6669 (4.0); 7.4094 (0.7); 7.4008 (3.4); 7.3956 (1.1); 7.3877 (1.2); 7.3823 (4.4); 7.3794 (3.4); 7.3692 (0.7); 7.3654 (1.2); 7.3606 (3.4); 7.2282 (1.7); 7.2114 (1.6); 7.1599 (4.2); 7.1577 (3.2); 7.1415 (4.2); 7.1394 (4.2); 7.1259 (0.9); 7.1232 (1.5); 7.1205 (0.8); 6.9293 (2.3); 6.9235 (2.3); 6.9092 (2.0); 6.9033 (2.2); 4.1188 (1.1); 4.1005 (2.5); 4.0854 (1.5); 4.0784 (2.3); 4.0570 (1.1); 4.0396 (0.9); 3.6095 (1.2); 3.5947 (1.8); 3.5881 (1.7); 3.5727 (0.8); 3.3109 (107.6); 3.2608 (0.8); 2.6740 (0.7); 2.6695 (1.0); 2.6650 (0.8); 2.6230 (1.2); 2.6048 (1.6); 2.5852 (1.2); 2.5230 (2.4); 2.5184 (3.5); 2.5097 (54.9); 2.5051 (120.8); 2.5004 (168.9); 2.4958 (117.7); 2.4912 (52.0); 2.4596 (0.9); 2.4552 (1.4); 2.4505 (1.6); 2.4459 (1.1); 2.4412 (0.5); 2.3318 (0.8); 2.3272 (1.1); 2.3226 (0.8); 2.2544 (0.7); 2.1705 (16.0); 2.1289 (2.4); 1.2301 (11.3); 1.2122 (11.0); 1.1729 (0.8); 1.1195 (1.5); 1.1012 (1.5); 0.0081 (2.0); -0.0002 (75.4); -0.0086 (2.2); -0.0502 (0.6) I.4-39: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.0631 (3.6); 8.0574 (3.6); 7.7333 (3.5); 7.5685 (0.7); 7.5619 (5.3); 7.5571 (1.6); 7.5455 (1.8); 7.5405 (6.0); 7.5340 (0.6); 7.3153 (1.7); 7.2989 (1.8); 7.1957 (4.0); 7.1942 (4.3); 7.1738 (3.9); 7.1722 (3.4); 7.1425 (2.4); 7.1409 (2.3); 7.1222 (2.7); 7.1207 (2.7); 6.9140 (2.4); 6.9084 (2.4); 6.8941 (2.0); 6.8883 (2.0); 4.3888 (0.5); 4.3813 (0.8); 4.3721 (0.8); 4.3633 (0.8); 4.3556 (0.6); 4.1511 (1.7); 4.1352 (1.7); 4.1255 (2.1); 4.1097 (1.6); 3.6624 (1.4); 3.6543 (1.4); 3.6369 (1.3); 3.6289 (1.2); 3.3411 (0.5); 3.3131 (184.7); 3.2805 (0.7); 3.2634 (1.5); 2.9757 (1.6); 2.9564 (1.8); 2.9334 (2.0); 2.9141 (1.8); 2.6743 (0.6); 2.6697 (0.8); 2.6650 (0.5); 2.5232 (2.4); 2.5185 (3.6); 2.5098 (43.9); 2.5052 (95.3); 2.5006 (133.6); 2.4959 (92.4); 2.4913 (40.4); 2.4690 (0.8); 2.4595 (0.7); 2.4553 (1.0); 2.4508 (1.2); 2.4460 (0.9); 2.4082 (1.5); 2.3986 (1.6); 2.3660 (1.3); 2.3562 (1.3); 2.3320 (0.6); 2.3274 (0.9); 2.3226 (0.6); 2.2797 (14.5); 2.2540 (0.6); 2.1379 (16.0); 2.0725 (0.5); 1.1764 (0.6); 0.0080 (2.2); -0.0002 (82.8); -0.0086 (2.4); -0.0500 (0.6) I.4-42: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.4569 (1.8); 8.0140 (1.1); 8.0059 (1.1); 7.9978 (1.1); 7.9896 (1.1); 7.9857 (1.1); 7.9775 (1.0); 7.9694 (1.0); 7.9613 (0.9); 7.7290 (0.8); 7.7209 (7.3); 7.7154 (2.1); 7.7038 (2.4); 7.6982 (8.6); 7.6902 (0.7); 7.4555 (1.0); 7.4475 (9.0); 7.4419 (2.3); 7.4303 (2.2); 7.4248 (7.6); 7.4167 (0.6); 7.3144 (1.8); 7.2977 (1.8); 7.2589 (1.0); 7.2460 (1.2); 7.2363 (1.2); 7.2314 (1.1); 7.2233 (1.2); 7.2184 (1.2); 7.2088 (1.1); 7.1957 (1.1); 6.7789 (0.7); 6.7701 (1.1); 6.7616 (0.8); 6.7592 (0.9); 6.7564 (0.8); 6.7499 (1.3); 6.7417 (0.7); 6.7366 (0.6); 6.7279 (0.9); 4.4168 (0.6); 4.4091 (0.8); 4.4004 (0.9); 4.3914 (0.8); 4.3838 (0.6); 4.1648 (1.8); 4.1484 (1.9); 4.1393 (2.2); 4.1231 (1.7); 4.0560 (0.5); 4.0383 (1.6); 4.0205 (1.6); 4.0027 (0.6); 3.6915 (1.7); 3.6827 (1.7); 3.6662 (1.7); 3.6573 (1.7); 3.5502 (1.3); 2.9905 (1.8); 2.9711 (1.9); 2.9481 (2.2); 2.9285 (2.0); 2.6747 (0.6); 2.6700 (0.8); 2.6654 (0.6); 2.5235 (2.5); 2.5188 (3.7); 2.5101 (48.2); 2.5055 (104.2); 2.5009 (144.6); 2.4963 (100.0); 2.4917 (43.8); 2.4554 (0.6); 2.4508 (0.9); 2.4444 (2.0); 2.4336 (1.7); 2.4019 (1.5); 2.3913 (1.4); 2.3323 (0.7); 2.3276 (0.9); 2.3231 (0.7); 1.9881 (7.4); 1.9084 (16.0); 1.1984 (0.7); 1.1925 (2.2); 1.1802 (1.5); 1.1747 (4.4); 1.1621 (0.7); 1.1569 (2.1); 0.0080 (1.3); -0.0002 (46.8); -0.0086 (1.4) I.4-43: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.4499 (1.7); 8.0179 (1.0); 8.0096 (1.0); 8.0016 (1.1); 7.9936 (1.0); 7.9893 (1.1); 7.9813 (1.0); 7.9731 (1.0); 7.9650 (1.0); 7.5471 (5.6); 7.5423 (1.6); 7.5307 (1.9); 7.5258 (6.4); 7.5191 (0.6); 7.3115 (1.7); 7.2949 (1.9); 7.2575 (1.0); 7.2445 (1.2); 7.2348 (1.2); 7.2300 (1.2); 7.2218 (1.2); 7.2170 (1.2); 7.2072 (1.2); 7.1940 (5.2); 7.1925 (4.9); 7.1720 (4.1); 7.1704 (3.6); 6.7761 (0.7); 6.7673 (1.0); 6.7564 (0.8); 6.7471 (1.3); 6.7389 (0.7); 6.7248 (0.9); 4.3928 (0.8); 4.3840 (0.9); 4.3756 (0.8); 4.1458 (1.8); 4.1297 (1.8); 4.1203 (2.3); 4.1040 (1.6); 3.6578 (1.5); 3.6492 (1.5); 3.6326 (1.5); 3.6242 (1.4); 3.3706 (26.6); 3.1089 (1.4); 3.0969 (1.4); 3.0906 (1.4); 3.0787 (1.4); 2.9634 (1.7); 2.9439 (1.9); 2.9211 (2.1); 2.9016 (1.9); 2.6744 (1.1); 2.6697 (1.6); 2.6651 (1.2); 2.5504 (0.7); 2.5457 (0.6); 2.5232 (4.0); 2.5185 (5.8); 2.5098 (87.0); 2.5052 (191.8); 2.5006 (268.7); 2.4960 (186.7); 2.4914 (81.8); 2.4597 (0.8); 2.4548 (1.2); 2.4503 (1.6); 2.4458 (1.4); 2.4073 (1.9); 2.3968 (1.8); 2.3649 (1.6); 2.3544 (1.5); 2.3367 (0.6); 2.3321 (1.3); 2.3274 (1.8); 2.3227 (1.3); 2.3180 (0.6); 2.2791 (15.3); 2.0725 (1.0); 1.9879 (1.1); 1.9081 (16.0); 1.1976 (2.6); 1.1794 (5.6); 1.1745 (0.9); 1.1611 (2.6); -0.0002 (16.0); -0.0085 (0.5) I.4-44: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.2290 (3.8); 8.2230 (3.6); 8.1023 (1.9); 8.0982 (1.9); 8.0816 (3.4); 8.0774 (3.4); 8.0609 (1.9); 8.0568 (1.7); 7.9072 (6.2); 7.9016 (2.4); 7.8900 (3.9); 7.8843 (15.9); 7.8797 (2.7); 7.8619 (3.0); 7.8573 (16.0); 7.8515 (3.2); 7.8401 (2.3); 7.8345 (6.2); 7.7652 (0.9); 7.7428 (0.7); 7.2088 (3.2); 7.1988 (2.9); 7.1950 (3.8); 7.1785 (2.5); 7.1748 (2.5); 7.1698 (2.1); 7.1661 (2.2); 7.1492 (2.3); 7.1457 (2.5); 7.1038 (1.7); 7.0845 (3.3); 7.0648 (1.9); 6.9714 (1.5); 6.9672 (1.6); 6.9586 (1.5); 6.9542 (2.0); 6.9483 (1.7); 6.9399 (1.7); 6.9355 (1.7); 6.9281 (0.9); 6.9196 (0.9); 6.9155 (0.8); 5.7537 (4.6); 4.4263 (1.4); 4.4176 (1.5); 4.4092 (1.5); 4.4009 (1.1); 4.2050 (2.7); 4.1886 (2.9); 4.1793 (3.4); 4.1630 (2.6); 3.7511 (2.3); 3.7418 (2.4); 3.7256 (2.2); 3.7162 (2.1); 3.3647 (3.3); 3.3492 (2.3); 3.3150 (562.8); 3.2845 (1.6); 3.2648 (4.7); 3.2162 (0.5); 3.0336 (2.7); 3.0140 (3.0); 2.9908 (3.5); 2.9712 (3.0); 2.6746 (1.5); 2.6699 (2.1); 2.6654 (1.4); 2.5552 (1.7); 2.5508 (2.5); 2.5462 (2.4); 2.5348 (1.6); 2.5300 (1.1); 2.5235 (4.6); 2.5188 (7.1); 2.5101 (108.1); 2.5055 (236.0); 2.5009 (331.8); 2.4963 (231.6); 2.4917 (104.9); 2.4696 (2.0); 2.4566 (4.0); 2.4509 (4.1); 2.4468 (5.1); 2.3324 (1.4); 2.3277 (2.1); 2.3232 (1.5); 2.0727 (0.6); 1.1744 (1.0); 0.8584 (0.7); 0.0080 (1.7); -0.0002 (63.7); -0.0086 (2.0) I.4-45: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.9073 (1.0); 7.9012 (1.1); 7.8840 (5.2); 7.8781 (6.1); 7.8736 (6.6); 7.8714 (5.6); 7.8505 (1.1); 7.8477 (0.7); 7.7149 (0.9); 7.7107 (1.3); 7.7039 (1.3); 7.6947 (1.1); 7.6907 (1.9); 7.6888 (1.1); 7.6852 (1.2); 7.5954 (0.8); 7.5907 (1.0); 7.5773 (1.9); 7.5722 (2.0); 7.5592 (1.6); 7.5525 (2.2); 7.5479 (0.8); 7.5409 (1.3); 7.5365 (1.5); 7.5330 (1.2); 7.5290 (1.4); 7.5224 (0.6); 7.5181 (0.6); 7.5147 (0.8); 7.5107 (0.7); 7.4980 (1.6); 7.4953 (1.6); 7.4914 (1.6); 7.4795 (1.0); 7.4763 (0.9); 5.7537 (16.0); 5.0869 (0.5); 5.0680 (0.8); 4.4238 (0.6); 4.4181 (0.6); 4.4038 (0.7); 4.3966 (1.1); 4.3903 (0.9); 4.3760 (0.6); 4.3693 (0.6); 4.1949 (0.6); 4.1894 (0.6); 4.1677 (0.5); 4.1614 (0.5); 4.0773 (0.6); 4.0717 (0.6); 4.0493 (0.6); 4.0436 (0.5); 3.3349 (25.3); 3.2438 (0.7); 3.2262 (0.6); 3.2191 (0.7); 3.1987 (0.9); 3.1812 (0.9); 3.1743 (0.7); 3.1569 (0.7); 3.0161 (0.8); 3.0094 (0.8); 2.9709 (0.6); 2.9641 (0.6); 2.9022 (0.7); 2.8956 (0.7); 2.8574 (0.6); 2.8507 (0.6); 2.6741 (1.1); 2.6695 (1.5); 2.6649 (1.1); 2.5229 (3.6); 2.5182 (5.4); 2.5096 (82.9); 2.5050 (183.7); 2.5003 (258.5); 2.4957 (178.9); 2.4911 (78.6); 2.4677 (1.0); 2.4553 (1.5); 2.4505 (1.8); 2.4459 (1.3); 2.3365 (0.5); 2.3317 (1.1); 2.3271 (1.5); 2.3225 (1.1); 2.0725 (0.5); 0.0080 (3.4); -0.0002 (129.6); -0.0085 (4.1); -0.0501 (2.0); -0.0641 (2.9) I.4-46: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.3583 (2.8); 8.3522 (2.8); 8.2506 (1.7); 8.2440 (1.7); 8.1648 (0.9); 8.1607 (0.9); 8.1440 (1.7); 8.1399 (1.8); 8.1287 (1.5); 8.1241 (2.0); 8.1192 (1.1); 8.1080 (2.8); 8.1039 (2.8); 8.0872 (1.5); 8.0831 (1.4); 7.7290 (3.0); 7.7233 (1.2); 7.7157 (6.6); 7.7111 (2.6); 7.7057 (4.2); 7.7032 (5.6); 7.6977 (3.2); 7.6926 (6.9); 7.6857 (1.8); 7.6799 (5.1); 7.2526 (3.5); 7.2468 (1.2); 7.2409 (5.7); 7.2351 (2.6); 7.2307 (4.9); 7.2236 (2.2); 7.2190 (7.7); 7.2139 (3.6); 7.2114 (2.6); 7.2080 (3.8); 7.2020 (1.8); 7.1960 (6.5); 7.1913 (2.8); 7.1858 (1.9); 7.1821 (1.8); 7.1753 (1.3); 7.1716 (1.4); 7.1655 (2.6); 7.1620 (2.7); 7.1459 (1.3); 7.1424 (1.3); 7.1181 (1.8); 7.1086 (2.2); 7.1038 (3.0); 7.0979 (3.3); 7.0899 (4.4); 7.0733 (1.8); 7.0629 (1.1); 6.9800 (1.2); 6.9757 (1.3); 6.9672 (1.3); 6.9627 (1.6); 6.9552 (1.5); 6.9486 (1.6); 6.9441 (1.5); 6.9413 (1.8); 6.9367 (1.7); 6.9290 (1.2); 6.9228 (1.1); 6.9182 (0.9); 6.9108 (0.5); 5.7544 (13.2); 4.5110 (0.8); 4.4971 (0.8); 4.1218 (1.4); 4.1081 (1.7); 4.0959 (2.0); 4.0911 (1.5); 4.0820 (2.1); 4.0790 (2.6); 4.0719 (3.9); 4.0650 (1.8); 4.0599 (3.4); 4.0485 (1.1); 4.0415 (1.0); 4.0392 (1.0); 4.0212 (0.7); 3.6255 (1.6); 3.6206 (1.6); 3.6058 (0.9); 3.5996 (1.6); 3.5947 (1.7); 3.5800 (2.8); 3.5743 (2.8); 3.5484 (0.7); 3.3698 (0.6); 3.3199 (102.6); 3.2698 (1.2); 2.9679 (1.5); 2.9501 (2.1); 2.9323 (1.5); 2.6081 (1.5); 2.5899 (2.0); 2.5702 (1.5); 2.5528 (0.8); 2.5248 (0.9); 2.5202 (1.4); 2.5115 (20.4); 2.5069 (44.8); 2.5023 (62.8); 2.4977 (44.0); 2.4931 (19.7); 2.4567 (0.6); 2.4522 (0.8); 2.4476 (0.6); 1.9889 (3.0); 1.2466 (0.6); 1.2186 (16.0); 1.2007 (15.7); 1.1932 (1.6); 1.1753 (1.9); 1.1575 (0.9); 1.1092 (9.0); 1.0909 (8.9); 0.8581 (1.1); - 0.0002 (11.1) I.4-47: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 9.3011 (0.8); 8.3178 (7.6); 8.3114 (7.8); 8.2233 (1.6); 8.2171 (1.3); 8.1356 (5.6); 7.8979 (3.7); 7.8928 (7.0); 7.8875 (3.6); 7.7586 (2.5); 7.7422 (2.6); 7.5776 (2.2); 7.5567 (2.7); 7.5535 (2.7); 7.5321 (1.3); 7.5107 (1.4); 7.4517 (8.3); 7.4340 (4.2); 7.4302 (9.3); 7.4137 (6.4); 7.3932 (3.5); 7.2236 (2.7); 7.2214 (3.0); 7.2185 (2.7); 7.2013 (2.3); 7.1985 (2.5); 7.1561 (0.8); 7.1414 (0.8); 7.1348 (0.9); 7.0394 (5.5); 7.0330 (5.3); 7.0180 (4.7); 7.0115 (4.9); 5.2979 (3.1); 4.3844 (1.3); 4.1862 (2.4); 4.1701 (2.1); 4.1605 (2.6); 4.1447 (2.1); 3.7295 (1.9); 3.7203 (1.9); 3.7035 (2.0); 3.6955 (1.9); 3.4103 (0.9); 3.3915 (1.2); 3.3734 (3.4); 3.3609 (3.1); 3.3553 (4.0); 3.3460 (3.3); 3.3116 (1178.7); 3.2632 (1.3); 3.0939 (3.3); 3.0773 (3.0); 3.0265 (2.1); 3.0073 (2.3); 2.9838 (2.8); 2.9647 (2.3); 2.6743 (2.8); 2.6698 (3.9); 2.6651 (2.6); 2.5231 (11.9); 2.5184 (17.2); 2.5098 (231.5); 2.5052 (496.6); 2.5006 (688.5); 2.4960 (477.6); 2.4914 (212.7); 2.4522 (2.3); 2.4432 (2.3); 2.4098 (1.7); 2.4008 (2.0); 2.3320 (2.9); 2.3274 (3.8); 2.3227 (2.8); 1.2499 (2.4); 1.2319 (4.8); 1.2136 (2.4); 1.1965 (8.1); 1.1783 (16.0); 1.1601 (7.8); -0.0002 (3.2) I.4-48: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.3213 (4.4); 8.3149 (4.2); 8.1320 (3.7); 7.7528 (1.8); 7.7361 (1.8); 7.5585 (4.9); 7.5371 (5.5); 7.5109 (0.6); 7.4494 (4.7); 7.4280 (5.0); 7.1955 (4.4); 7.1749 (4.0); 7.0358 (3.2); 7.0294 (3.0); 7.0144 (2.8); 7.0079 (2.7); 4.3756 (1.0); 4.1577 (1.6); 4.1422 (1.7); 4.1321 (2.0); 4.1163 (1.6); 3.6689 (1.6); 3.6610 (1.5); 3.6430 (1.4); 3.6347 (1.4); 3.5060 (1.0); 3.3641 (1.2); 3.3084 (380.4); 3.2744 (3.7); 3.2605 (3.6); 2.9854 (1.9); 2.9659 (1.8); 2.9427 (2.0); 2.9232 (1.9); 2.6739 (2.4); 2.6693 (3.1); 2.6648 (2.4); 2.5094 (170.5); 2.5049 (329.8); 2.5003 (436.0); 2.4957 (306.6); 2.4912 (145.4); 2.4027 (5.7); 2.3933 (5.3); 2.3601 (4.4); 2.3511 (4.2); 2.3318 (4.6); 2.3271 (5.2); 2.3224 (4.3); 2.2803 (16.0); 2.0720 (0.9); 1.2984 (0.7); 1.2585 (1.0); 1.2361 (1.6); 1.1722 (0.7); 0.0080 (1.5); -0.0002 (34.6); -0.0086 (1.4) I.4-49: 1 H-NMR (400.0 MHz, CDCl 3 ): δ= 7.5807 (1.7); 7.5611 (2.3); 7.5184 (3.4); 7.4208 (2.1); 7.4121 (1.2); 7.4023 (2.6); 7.3917 (1.6); 7.3807 (1.8); 7.3241 (1.8); 7.3035 (1.4); 7.2931 (1.0); 7.2875 (1.3); 7.2828 (1.2); 7.2812 (1.2); 7.2804 (1.2); 7.2788 (1.3); 7.2772 (1.7); 7.2756 (2.1); 7.2748 (2.2); 7.2740 (2.4); 7.2732 (2.7); 7.2724 (3.1); 7.2716 (3.4); 7.2709 (3.6); 7.2700 (3.9); 7.2692 (4.3); 7.2685 (5.0); 7.2677 (5.5); 7.2669 (6.2); 7.2661 (7.3); 7.2652 (8.6); 7.2644 (10.9); 7.2636 (13.9); 7.2628 (19.1); 7.2595 (583.5); 7.2555 (7.5); 7.2547 (5.0); 7.2538 (3.8); 7.2530 (3.0); 7.2522 (2.4); 7.2514 (2.1); 7.2506 (1.5); 7.2498 (1.3); 7.2491 (1.0); 7.2482 (0.8); 7.2474 (0.8); 7.2458 (0.7); 7.2450 (0.6); 7.2275 (1.4); 7.2218 (2.3); 7.2164 (2.2); 7.2095 (6.7); 7.1902 (0.6); 6.9955 (3.4); 5.1885 (0.6); 4.2691 (1.1); 4.2483 (0.9); 4.2267 (0.8); 4.2116 (0.6); 4.2015 (0.8); 4.1863 (0.9); 3.2349 (0.6); 3.2174 (0.6); 3.1844 (0.6); 3.1667 (0.6); 3.1063 (0.7); 3.0990 (0.7); 3.0832 (0.7); 3.0752 (0.7); 3.0322 (0.5); 2.1890 (10.0); 2.0439 (1.2); 1.5361 (16.0); 1.2588 (1.2); 0.8819 (1.7); 0.8639 (0.7); 0.1460 (0.6); 0.0112 (1.3); 0.0104 (1.5); 0.0080 (8.1); 0.0064 (3.1); 0.0056 (3.3); 0.0048 (4.2); 0.0039 (5.1); -0.0002 (244.4); -0.0042 (5.1); -0.0050 (3.3); -0.0059 (2.7); -0.0067 (2.3); - 0.0084 (6.9); -0.0146 (0.6); -0.0501 (2.3); -0.1494 (0.7) I.4-50: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 9.0282 (1.6); 9.0245 (1.7); 9.0172 (1.7); 8.6478 (0.9); 8.6273 (0.9); 8.0848 (1.6); 8.0626 (5.2); 8.0570 (3.9); 7.9759 (3.3); 7.8752 (1.4); 7.8577 (1.8); 7.7680 (1.6); 7.7480 (2.6); 7.7292 (1.7); 7.7128 (0.9); 7.6308 (0.8); 7.6143 (0.8); 7.1592 (2.4); 7.1389 (2.8); 6.9222 (2.2); 6.9166 (2.2); 6.9020 (1.9); 6.8964 (1.9); 5.7546 (0.6); 4.5690 (0.8); 4.3533 (1.6); 4.3365 (1.7); 4.3290 (2.0); 4.3122 (1.6); 3.8559 (2.9); 3.8449 (3.1); 3.8316 (3.4); 3.8206 (3.7); 3.7582 (4.9); 3.0082 (1.4); 2.9882 (1.6); 2.9660 (1.8); 2.9462 (1.6); 2.6710 (0.6); 2.5242 (2.0); 2.5109 (37.9); 2.5064 (80.4); 2.5018 (111.1); 2.4972 (82.2); 2.4927 (39.8); 2.4558 (2.3); 2.4473 (1.3); 2.4425 (1.9); 2.3334 (0.5); 2.3285 (0.7); 2.3239 (0.5); 2.1988 (16.0); 1.9092 (3.2); 1.2078 (0.6); 1.1897 (1.3); 1.1714 (0.6); -0.0002 (1.0) I.4-51: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.1600 (1.6); 8.1578 (2.8); 8.1547 (2.9); 8.1527 (2.3); 8.1512 (2.3); 8.0530 (4.5); 8.0474 (4.3); 8.0432 (1.4); 8.0381 (1.4); 8.0363 (1.4); 8.0335 (1.1); 8.0288 (1.4); 8.0229 (1.3); 7.7626 (3.6); 7.6171 (0.5); 7.6105 (6.0); 7.6084 (5.0); 7.6014 (2.7); 7.5980 (3.0); 7.5960 (3.3); 7.5945 (3.0); 7.3303 (1.7); 7.3141 (1.7); 7.1467 (2.3); 7.1453 (2.3); 7.1264 (2.7); 7.1250 (2.7); 6.9209 (2.3); 6.9152 (2.3); 6.9008 (2.0); 6.8950 (1.9); 4.4267 (0.5); 4.4190 (0.7); 4.4100 (0.8); 4.4008 (0.7); 4.3937 (0.6); 4.2053 (1.5); 4.1891 (1.5); 4.1796 (1.9); 4.1636 (1.4); 3.7622 (1.4); 3.7534 (1.3); 3.7365 (1.2); 3.7280 (1.2); 3.3638 (65.6); 3.3134 (1.1); 3.0354 (1.5); 3.0159 (1.6); 2.9927 (1.9); 2.9731 (1.7); 2.6704 (0.6); 2.5239 (1.2); 2.5192 (1.8); 2.5105 (31.4); 2.5059 (69.2); 2.5013 (97.4); 2.4967 (67.9); 2.4921 (30.0); 2.4754 (1.7); 2.4555 (0.8); 2.4509 (1.2); 2.4428 (1.7); 2.4326 (1.4); 2.3281 (0.6); 2.1423 (16.0); 2.0729 (1.7); 1.1795 (0.7); 0.0080 (1.0); -0.0002 (34.5); -0.0086 (1.0) I.4-52: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.0481 (3.5); 8.0424 (3.5); 7.9171 (3.8); 7.9117 (1.6); 7.8999 (2.0); 7.8942 (8.7); 7.8894 (1.5); 7.8655 (1.5); 7.8606 (8.7); 7.8549 (1.8); 7.8432 (1.4); 7.8378 (3.8); 7.7401 (3.6); 7.3094 (1.8); 7.2930 (1.7); 7.1448 (2.4); 7.1434 (2.3); 7.1246 (2.8); 7.1231 (2.8); 6.9202 (2.3); 6.9146 (2.3); 6.9002 (1.9); 6.8945 (1.9); 4.4279 (0.5); 4.4197 (0.7); 4.4113 (0.9); 4.4034 (0.8); 4.3948 (0.6); 4.2122 (1.5); 4.1960 (1.5); 4.1865 (1.9); 4.1704 (1.4); 3.7614 (1.3); 3.7531 (1.3); 3.7357 (1.2); 3.7272 (1.1); 3.3114 (70.1); 3.0520 (1.4); 3.0325 (1.6); 3.0092 (1.8); 2.9897 (1.6); 2.6698 (0.6); 2.5234 (1.4); 2.5186 (2.2); 2.5100 (34.3); 2.5054 (75.7); 2.5008 (106.7); 2.4961 (74.4); 2.4915 (34.3); 2.4593 (1.6); 2.4497 (1.8); 2.3275 (0.6); 2.1362 (16.0); 2.0728 (1.2); 0.0080 (1.4); 0.0048 (0.5); -0.0002 (48.5); -0.0085 (1.4) I.4-53: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 9.0202 (1.2); 9.0163 (1.3); 9.0094 (1.2); 9.0055 (1.2); 8.6258 (0.7); 8.6071 (0.6); 8.3850 (1.6); 8.3792 (1.5); 8.1303 (0.8); 8.1262 (0.9); 8.1095 (1.6); 8.1054 (1.6); 8.0888 (1.0); 8.0846 (0.9); 8.0729 (1.2); 8.0545 (1.3); 7.8544 (1.0); 7.8380 (1.4); 7.7594 (1.3); 7.7396 (1.7); 7.7297 (0.8); 7.7200 (1.4); 7.7087 (0.7); 7.6980 (0.6); 7.3997 (0.8); 7.3839 (0.7); 7.2175 (1.0); 7.2139 (1.0); 7.1970 (1.1); 7.1934 (1.1); 7.1881 (0.9); 7.1846 (1.0); 7.1678 (1.1); 7.1642 (1.2); 7.1105 (0.8); 7.0915 (1.4); 7.0718 (0.8); 6.9765 (0.7); 6.9723 (0.7); 6.9638 (0.8); 6.9594 (0.9); 6.9537 (0.7); 6.9451 (0.8); 6.9407 (0.8); 5.7549 (16.0); 4.5910 (0.6); 4.5751 (0.6); 4.3492 (1.4); 4.3323 (1.4); 4.3248 (1.8); 4.3079 (1.3); 3.8451 (3.9); 3.8339 (4.2); 3.8207 (4.3); 3.8098 (4.1); 3.1073 (0.8); 3.0952 (0.8); 3.0890 (2.6); 3.0769 (2.6); 3.0707 (2.6); 3.0587 (2.6); 3.0526 (0.9); 3.0405 (0.8); 2.9979 (1.3); 2.9780 (1.4); 2.9559 (1.6); 2.9361 (1.4); 2.6708 (0.7); 2.5518 (0.7); 2.5243 (1.6); 2.5196 (2.5); 2.5110 (37.4); 2.5064 (82.4); 2.5017 (116.7); 2.4971 (81.8); 2.4925 (36.4); 2.4708 (1.8); 2.4610 (0.6); 2.4562 (1.0); 2.4517 (1.2); 2.4472 (1.1); 2.4422 (1.5); 2.4288 (1.1); 2.3285 (0.7); 2.3239 (0.5); 2.0734 (9.7); 1.2073 (5.0); 1.1891 (10.8); 1.1708 (5.0); 0.0081 (1.8); 0.0049 (0.5); -0.0002 (68.8); -0.0086 (2.0) I.4-54: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.9897 (1.1); 8.9856 (1.2); 8.9791 (1.2); 8.9749 (1.1); 8.5619 (0.6); 8.5423 (0.6); 8.1743 (1.6); 8.1705 (1.6); 8.1535 (1.7); 8.1497 (1.6); 8.0996 (2.4); 8.0434 (1.0); 8.0264 (1.1); 7.8288 (1.0); 7.8106 (1.3); 7.7618 (0.9); 7.7443 (0.9); 7.7331 (1.3); 7.7130 (1.6); 7.6941 (0.9); 7.6866 (0.8); 7.6757 (0.7); 7.6657 (0.7); 7.6547 (0.7); 7.4276 (1.8); 7.4240 (1.8); 7.4075 (1.9); 7.4039 (1.9); 7.2715 (0.8); 7.2679 (0.8); 7.2529 (1.1); 7.2501 (1.3); 7.2323 (0.9); 7.2286 (0.9); 7.1928 (0.8); 7.1891 (0.9); 7.1730 (0.9); 7.1692 (0.9); 7.0446 (0.5); 7.0246 (0.7); 7.0208 (0.6); 7.0064 (0.7); 7.0027 (0.6); 6.9924 (1.2); 6.9884 (1.3); 6.9739 (1.4); 6.9724 (1.4); 6.9700 (1.3); 6.9684 (1.4); 6.9540 (1.1); 6.9500 (1.1); 6.8197 (0.8); 6.8158 (0.8); 6.7998 (0.6); 6.7956 (0.7); 6.5557 (0.6); 4.5556 (0.5); 4.3635 (1.2); 4.3468 (1.2); 4.3390 (1.5); 4.3223 (1.1); 4.0560 (0.8); 4.0381 (2.4); 4.0203 (2.4); 4.0025 (0.9); 3.8530 (1.5); 3.8424 (1.5); 3.8286 (1.6); 3.8177 (1.6); 3.6332 (6.3); 3.0977 (0.9); 3.0857 (0.9); 3.0795 (0.9); 3.0675 (0.8); 3.0101 (1.1); 2.9903 (1.2); 2.9682 (1.4); 2.9483 (1.2); 2.6748 (1.0); 2.6702 (1.5); 2.6654 (1.0); 2.5513 (1.6); 2.5468 (1.4); 2.5236 (3.9); 2.5189 (5.6); 2.5103 (80.4); 2.5056 (176.6); 2.5010 (248.4); 2.4964 (172.6); 2.4918 (76.0); 2.4722 (1.9); 2.4597 (2.3); 2.4557 (2.6); 2.4510 (3.4); 2.4464 (2.6); 2.4416 (1.4); 2.4303 (1.2); 2.4171 (1.0); 2.4008 (0.6); 2.3324 (1.2); 2.3278 (1.6); 2.3232 (1.1); 2.0728 (1.4); 1.9880 (10.9); 1.9084 (16.0); 1.2028 (1.6); 1.1923 (3.2); 1.1846 (3.4); 1.1745 (6.7); 1.1663 (1.7); 1.1567 (3.2); 0.0080 (3.4); 0.0063 (0.8); 0.0055 (0.8); 0.0046 (1.0); 0.0038 (1.4); -0.0002 (127.5); -0.0027 (5.9); -0.0043 (2.5); - 0.0052 (1.8); -0.0060 (1.5); -0.0068 (1.3); -0.0085 (3.9); -0.0502 (1.2) I.4-55: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 9.0260 (2.1); 8.1623 (10.4); 8.1585 (10.7); 8.1415 (11.6); 8.1377 (10.9); 8.0802 (1.7); 8.0760 (1.6); 8.0591 (1.6); 8.0554 (1.7); 7.9792 (16.0); 7.6227 (7.6); 7.6061 (7.6); 7.5301 (1.4); 7.5229 (2.3); 7.5115 (11.7); 7.5057 (13.1); 7.4859 (13.6); 7.4803 (11.6); 7.4687 (1.9); 7.4617 (2.8); 7.4580 (2.1); 7.4113 (11.7); 7.4077 (12.4); 7.3913 (12.7); 7.3876 (12.8); 7.3271 (0.8); 7.3050 (1.3); 7.2881 (0.9); 7.2690 (5.2); 7.2653 (5.1); 7.2503 (7.1); 7.2474 (8.7); 7.2298 (5.8); 7.2260 (5.4); 7.1767 (0.7); 7.1733 (0.8); 7.1570 (0.8); 7.1536 (0.7); 7.0849 (1.3); 7.0809 (1.3); 7.0609 (1.5); 7.0463 (1.2); 7.0419 (3.2); 7.0358 (4.6); 7.0298 (2.6); 7.0184 (5.5); 7.0126 (9.3); 7.0069 (4.8); 6.9953 (3.1); 6.9875 (10.2); 6.9835 (11.0); 6.9689 (9.2); 6.9674 (8.8); 6.9650 (9.0); 6.9635 (8.9); 6.9490 (7.3); 6.9450 (6.9); 6.7932 (0.8); 6.7895 (0.8); 6.7692 (0.8); 6.5454 (0.6); 6.5257 (0.6); 5.7538 (1.6); 4.4262 (1.4); 4.4172 (2.4); 4.4102 (3.3); 4.4012 (3.7); 4.3921 (3.5); 4.3841 (2.6); 4.3747 (1.6); 4.3662 (0.9); 4.1614 (7.0); 4.1452 (7.3); 4.1354 (8.8); 4.1194 (6.7); 3.7257 (6.2); 3.7173 (6.0); 3.6998 (5.7); 3.6915 (5.5); 3.3963 (3.1); 3.3480 (256.4); 3.2975 (4.3); 3.1280 (0.9); 3.1159 (0.9); 3.1098 (2.6); 3.0978 (2.4); 3.0916 (2.6); 3.0795 (2.5); 3.0613 (0.9); 3.0443 (7.2); 3.0247 (7.9); 3.0014 (9.1); 2.9820 (8.0); 2.6749 (2.2); 2.6702 (3.3); 2.6657 (2.2); 2.5513 (3.2); 2.5237 (7.1); 2.5190 (10.2); 2.5104 (165.9); 2.5058 (365.7); 2.5011 (514.8); 2.4965 (359.2); 2.4919 (158.6); 2.4769 (9.0); 2.4671 (8.5); 2.4558 (5.2); 2.4512 (6.5); 2.4468 (4.9); 2.4341 (6.7); 2.4241 (6.5); 2.3326 (2.5); 2.3280 (3.2); 2.3233 (2.3); 2.0729 (0.7); 1.9881 (0.9); 1.9086 (0.8); 1.1975 (4.9); 1.1794 (10.4); 1.1612 (4.9); 0.8583 (0.7); 0.8339 (0.5); 0.0080 (2.7); -0.0002 (91.5); -0.0085 (2.6); -0.0501 (0.6) I.4-56: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.9698 (2.1); 8.9657 (2.3); 8.9594 (2.2); 8.9550 (2.1); 8.5855 (1.8); 8.5146 (1.2); 8.4958 (1.3); 8.0356 (1.0); 8.0255 (2.2); 8.0214 (2.3); 8.0113 (1.2); 8.0048 (2.4); 8.0012 (2.3); 7.9909 (1.0); 7.9828 (0.9); 7.7965 (1.6); 7.7932 (1.7); 7.7782 (2.5); 7.7748 (2.3); 7.7108 (2.4); 7.6911 (2.8); 7.6720 (1.6); 7.6553 (1.6); 7.6447 (1.5); 7.6344 (1.5); 7.6235 (1.4); 7.4327 (1.7); 7.4154 (1.6); 7.2782 (1.0); 7.2652 (1.1); 7.2556 (1.1); 7.2507 (1.1); 7.2424 (1.1); 7.2377 (1.0); 7.2281 (1.1); 7.2149 (1.0); 6.7850 (0.7); 6.7763 (0.9); 6.7652 (0.9); 6.7558 (1.2); 6.7479 (0.7); 6.7336 (0.9); 4.5550 (0.9); 4.3655 (1.8); 4.3488 (1.8); 4.3408 (2.4); 4.3242 (1.7); 4.0561 (0.7); 4.0381 (2.0); 4.0204 (2.0); 4.0026 (0.8); 3.8438 (2.2); 3.8328 (2.4); 3.8187 (2.4); 3.8082 (2.5); 3.7188 (2.9); 3.1033 (0.8); 3.0913 (0.7); 3.0852 (0.7); 3.0731 (0.8); 3.0016 (1.7); 2.9818 (1.8); 2.9595 (2.1); 2.9397 (1.9); 2.6744 (1.4); 2.6697 (1.9); 2.6651 (1.4); 2.5233 (4.7); 2.5186 (7.0); 2.5099 (109.9); 2.5053 (240.8); 2.5007 (337.6); 2.4961 (235.8); 2.4915 (104.4); 2.4651 (2.5); 2.4512 (3.2); 2.4460 (1.9); 2.4228 (1.7); 2.4105 (2.0); 2.3322 (1.6); 2.3274 (2.1); 2.3230 (1.5); 1.9879 (8.7); 1.9083 (16.0); 1.2000 (1.4); 1.1923 (2.5); 1.1819 (3.0); 1.1746 (5.2); 1.1638 (1.4); 1.1568 (2.5); 0.0080 (2.6); -0.0002 (100.8); -0.0085 (3.0); -0.0501 (0.6) I.4-57: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.4557 (3.2); 8.0108 (1.9); 8.0028 (1.9); 7.9946 (1.8); 7.9865 (1.9); 7.9827 (2.0); 7.9745 (1.8); 7.9663 (1.8); 7.9582 (1.7); 7.5018 (5.0); 7.4961 (5.6); 7.4763 (5.6); 7.4707 (4.5); 7.2935 (3.4); 7.2766 (3.4); 7.2617 (1.9); 7.2488 (2.0); 7.2392 (2.0); 7.2342 (2.0); 7.2260 (2.1); 7.2212 (2.0); 7.2115 (1.9); 7.1986 (1.8); 7.0404 (1.2); 7.0348 (2.0); 7.0290 (1.0); 7.0174 (2.3); 7.0116 (3.9); 7.0058 (1.8); 6.9943 (1.3); 6.9884 (1.9); 6.7832 (1.2); 6.7741 (1.9); 6.7633 (1.6); 6.7541 (2.2); 6.7459 (1.4); 6.7320 (1.6); 6.7232 (0.8); 4.4072 (1.8); 4.3980 (1.6); 4.1563 (3.0); 4.1397 (3.2); 4.1305 (3.8); 4.1139 (2.9); 4.0560 (0.8); 4.0382 (2.2); 4.0204 (2.2); 4.0026 (0.6); 3.7204 (2.7); 3.7116 (2.7); 3.6949 (2.5); 3.6858 (2.4); 3.3177 (146.9); 3.2677 (1.2); 3.1139 (0.6); 3.0958 (0.6); 3.0840 (0.6); 3.0295 (3.2); 3.0098 (3.4); 2.9867 (3.8); 2.9670 (3.4); 2.6742 (2.1); 2.6695 (3.0); 2.6649 (2.1); 2.5230 (8.3); 2.5183 (12.4); 2.5097 (167.0); 2.5051 (361.6); 2.5005 (501.6); 2.4958 (348.5); 2.4912 (154.8); 2.4760 (4.8); 2.4554 (2.9); 2.4507 (3.7); 2.4442 (4.0); 2.4329 (2.8); 2.4006 (0.7); 2.3319 (2.3); 2.3272 (3.2); 2.3227 (2.2); 2.0724 (1.3); 1.9878 (10.2); 1.9079 (16.0); 1.2342 (0.6); 1.1924 (3.0); 1.1746 (6.4); 1.1568 (3.1); 0.0080 (3.9); -0.0002 (141.5); - 0.0085 (4.4); -0.0499 (0.8) I.4-58: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.5964 (1.2); 8.4671 (0.8); 8.0371 (0.5); 8.0289 (1.1); 8.0208 (1.3); 8.0127 (0.9); 8.0045 (0.8); 8.0004 (1.2); 7.9923 (1.0); 7.9842 (0.7); 7.9760 (0.6); 7.7237 (1.7); 7.7177 (0.7); 7.7118 (3.2); 7.7064 (1.4); 7.7004 (4.5); 7.6945 (1.7); 7.6893 (3.7); 7.6831 (0.8); 7.6772 (2.6); 7.2741 (0.7); 7.2611 (1.0); 7.2524 (2.6); 7.2465 (1.6); 7.2419 (3.6); 7.2296 (3.1); 7.2201 (6.2); 7.2145 (2.2); 7.2078 (2.7); 7.1971 (3.4); 6.7891 (0.5); 6.7802 (0.7); 6.7670 (0.7); 6.7584 (1.2); 6.7499 (0.8); 6.7383 (1.1); 6.7301 (0.7); 4.1225 (0.7); 4.1089 (0.8); 4.0964 (1.3); 4.0825 (1.7); 4.0747 (2.0); 4.0624 (1.8); 4.0523 (0.6); 4.0442 (0.5); 3.6294 (0.8); 3.6247 (0.8); 3.6032 (0.8); 3.5987 (0.8); 3.5818 (1.4); 3.5760 (1.4); 3.3223 (86.8); 3.2727 (0.7); 3.1267 (0.8); 3.1146 (0.8); 3.1085 (2.5); 3.0964 (2.5); 3.0902 (2.6); 3.0782 (2.5); 3.0720 (0.8); 3.0600 (0.7); 2.9770 (0.8); 2.9590 (1.0); 2.9412 (0.8); 2.6745 (0.9); 2.6699 (1.3); 2.6653 (1.0); 2.6096 (0.8); 2.5912 (1.0); 2.5719 (0.7); 2.5344 (0.6); 2.5297 (0.6); 2.5234 (3.0); 2.5187 (4.6); 2.5100 (72.6); 2.5054 (160.5); 2.5008 (225.5); 2.4962 (156.9); 2.4916 (68.9); 2.4695 (0.7); 2.4602 (0.6); 2.4554 (1.1); 2.4508 (1.5); 2.4463 (1.1); 2.3322 (1.0); 2.3276 (1.4); 2.3230 (1.0); 2.0727 (0.8); 1.9083 (16.0); 1.2153 (8.4); 1.1976 (12.2); 1.1799 (10.4); 1.1617 (4.7); 1.1027 (4.6); 1.0844 (4.6); -0.0002 (12.7) I.4-59: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 7.6164 (1.1); 7.6119 (1.1); 7.6035 (1.4); 7.5985 (2.1); 7.5937 (1.5); 7.5908 (1.5); 7.5855 (1.8); 7.5807 (1.7); 7.5774 (2.0); 7.5725 (1.4); 7.5644 (1.4); 7.5597 (1.3); 7.5218 (1.6); 7.5176 (2.0); 7.5018 (4.9); 7.4982 (5.3); 7.4805 (4.1); 7.4773 (4.0); 7.4728 (2.4); 7.4652 (2.9); 7.4607 (2.5); 7.4549 (1.7); 7.4517 (1.7); 7.4472 (2.5); 7.4424 (2.4); 7.4136 (3.1); 7.4103 (2.9); 7.3950 (2.9); 7.3754 (1.6); 7.3720 (1.6); 7.3654 (1.0); 7.3624 (1.5); 7.3581 (1.4); 7.3524 (1.1); 7.3424 (3.5); 7.3380 (2.7); 7.3316 (1.9); 7.3272 (1.7); 7.3220 (1.0); 7.3160 (2.2); 7.3118 (2.8); 7.2955 (1.2); 7.2906 (0.8); 7.2846 (2.6); 7.2792 (1.5); 7.2675 (2.5); 7.2650 (2.2); 7.2624 (1.9); 7.2480 (2.0); 7.2428 (1.2); 5.7537 (16.0); 5.1190 (0.9); 5.0977 (1.3); 5.0739 (0.9); 4.2810 (1.3); 4.2553 (1.9); 4.2344 (1.5); 4.0036 (1.8); 3.9958 (1.7); 3.9773 (1.5); 3.9699 (1.4); 3.3785 (8.6); 3.0723 (1.8); 3.0477 (2.1); 3.0280 (2.9); 3.0034 (2.4); 2.8529 (2.0); 2.8439 (1.9); 2.8085 (1.3); 2.7998 (1.4); 2.6739 (1.2); 2.6693 (1.8); 2.6645 (1.4); 2.6602 (0.6); 2.5501 (0.5); 2.5228 (3.9); 2.5181 (5.7); 2.5094 (102.3); 2.5048 (227.3); 2.5002 (322.9); 2.4955 (224.9); 2.4909 (99.5); 2.4651 (1.2); 2.4595 (1.3); 2.4548 (1.7); 2.4502 (2.1); 2.4455 (1.6); 2.4003 (0.6); 2.3363 (0.9); 2.3315 (1.5); 2.3269 (2.1); 2.3223 (1.5); 0.1460 (0.5); 0.0081 (5.1); 0.0041 (0.9); -0.0002 (221.5); -0.0086 (6.8); -0.0300 (0.6); -0.0501 (1.0); -0.1496 (0.6) I.4-60: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.7261 (1.8); 7.7220 (2.9); 7.7188 (2.6); 7.7086 (1.9); 7.7055 (2.5); 7.7034 (3.8); 7.7004 (2.3); 7.6166 (1.0); 7.6066 (1.6); 7.6024 (1.7); 7.5897 (3.0); 7.5830 (3.4); 7.5714 (3.8); 7.5650 (3.3); 7.5539 (3.2); 7.5520 (3.4); 7.5499 (3.7); 7.5478 (3.5); 7.5361 (2.7); 7.5342 (2.9); 7.5291 (6.1); 7.5241 (3.9); 7.5136 (2.7); 7.5101 (3.5); 7.5044 (2.0); 7.4941 (2.4); 7.4903 (1.9); 7.4745 (1.0); 7.4704 (1.2); 7.3644 (1.4); 7.3438 (4.5); 7.3388 (3.2); 7.3311 (1.6); 7.3168 (2.3); 7.3126 (2.9); 7.2958 (1.2); 7.2863 (1.6); 7.2826 (1.9); 7.2660 (2.4); 7.2496 (1.1); 7.2464 (1.2); 5.7537 (16.0); 5.1308 (0.9); 5.1094 (1.3); 5.0853 (1.0); 4.2966 (1.5); 4.2711 (2.0); 4.2500 (1.6); 4.0603 (1.4); 4.0525 (1.2); 4.0337 (1.1); 4.0259 (1.1); 3.9648 (1.3); 3.9572 (1.3); 3.9387 (1.1); 3.9309 (1.1); 3.3105 (122.6); 3.2604 (0.8); 3.0927 (1.9); 3.0823 (1.8); 3.0681 (1.8); 3.0577 (1.6); 3.0484 (1.8); 3.0377 (1.9); 3.0238 (1.4); 3.0131 (1.5); 2.9080 (1.5); 2.8994 (1.6); 2.8639 (1.0); 2.8550 (1.0); 2.8177 (1.5); 2.8089 (1.4); 2.7736 (1.0); 2.7645 (1.2); 2.6739 (2.0); 2.6693 (2.7); 2.6646 (1.9); 2.5228 (7.2); 2.5181 (10.4); 2.5094 (150.0); 2.5048 (327.1); 2.5002 (459.8); 2.4955 (318.0); 2.4909 (138.3); 2.4549 (2.0); 2.4503 (2.6); 2.4456 (1.8); 2.4005 (0.7); 2.3317 (2.0); 2.3270 (2.8); 2.3223 (2.0); 1.2338 (0.7); 1.1872 (2.8); 1.1692 (5.2); 1.1513 (2.7); 0.1464 (0.6); 0.0081 (6.3); - 0.0002 (244.3); -0.0086 (7.1); -0.0500 (1.2); -0.1499 (0.8) I.4-61: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.7245 (2.7); 7.7208 (2.6); 7.7137 (1.2); 7.7100 (1.7); 7.7064 (3.7); 7.7036 (3.0); 7.7017 (2.4); 7.6969 (1.0); 7.6945 (1.6); 7.6920 (1.0); 7.6826 (2.4); 7.6797 (3.2); 7.6752 (3.0); 7.6724 (3.3); 7.6675 (2.2); 7.6605 (3.6); 7.6579 (3.6); 7.6532 (4.0); 7.6505 (4.3); 7.6282 (2.0); 7.6254 (1.7); 7.6168 (1.0); 7.6082 (1.9); 7.5997 (1.2); 7.5939 (2.2); 7.5916 (2.0); 7.5848 (3.6); 7.5810 (1.4); 7.5762 (2.4); 7.5710 (3.0); 7.5656 (3.8); 7.5577 (3.9); 7.5555 (4.0); 7.5535 (4.2); 7.5519 (4.6); 7.5486 (3.4); 7.5468 (3.1); 7.5413 (4.5); 7.5381 (3.7); 7.5276 (1.3); 7.5239 (2.6); 7.5209 (3.2); 7.5109 (2.0); 7.5085 (1.8); 7.5050 (1.0); 7.4991 (0.6); 7.4238 (2.6); 7.4216 (2.9); 7.4112 (1.6); 7.4052 (3.9); 7.4028 (4.7); 7.3929 (1.6); 7.3890 (1.7); 7.3837 (3.8); 7.3814 (2.7); 7.3713 (1.5); 7.3660 (1.9); 7.3445 (1.5); 7.1991 (0.6); 7.1877 (1.6); 7.1855 (1.6); 7.1692 (2.6); 7.1673 (2.7); 7.1507 (1.2); 7.1484 (1.2); 7.1391 (0.8); 7.1208 (1.4); 7.1023 (0.7); 5.7536 (16.0); 5.1207 (0.6); 5.1001 (0.9); 5.0807 (0.6); 4.7360 (0.7); 4.7195 (1.9); 4.7014 (1.7); 4.6804 (1.0); 4.3925 (0.5); 4.3736 (0.6); 4.3633 (1.0); 4.3522 (0.6); 4.3453 (0.5); 4.2238 (0.9); 4.1980 (1.6); 4.1924 (1.9); 4.1838 (1.8); 4.1765 (1.4); 4.1719 (1.8); 4.1666 (1.8); 4.1045 (1.2); 4.0890 (1.2); 4.0790 (0.8); 4.0634 (0.8); 4.0123 (1.3); 3.9841 (1.1); 3.3096 (79.7); 3.2600 (0.7); 3.2391 (1.0); 3.2330 (1.3); 3.2149 (2.1); 3.1970 (1.5); 3.1743 (1.3); 3.1560 (2.0); 3.1378 (1.3); 3.1008 (0.7); 3.0824 (0.6); 2.6739 (1.2); 2.6692 (1.6); 2.6645 (1.1); 2.5227 (3.8); 2.5180 (5.6); 2.5093 (83.8); 2.5048 (183.4); 2.5001 (258.6); 2.4955 (178.7); 2.4909 (77.9); 2.4669 (0.8); 2.4550 (1.3); 2.4505 (1.6); 2.4460 (1.2); 2.3363 (0.6); 2.3317 (1.1); 2.3269 (1.7); 2.3223 (1.1); 2.0953 (0.6); 1.2985 (12.8); 1.2803 (12.4); 1.2348 (0.5); 1.1916 (1.8); 1.1735 (3.5); 1.1554 (1.7); 1.1081 (3.6); 1.0928 (3.5); 1.0897 (4.0); 1.0745 (2.9); 0.0081 (4.7); 0.0057 (1.3); 0.0049 (1.5); 0.0040 (2.0); -0.0002 (169.9); -0.0057 (1.7); -0.0066 (1.4); -0.0086 (4.7); - 0.0495 (0.7) I.4-62: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.7424 (0.5); 7.7161 (0.5); 7.7081 (4.8); 7.7025 (1.4); 7.6909 (1.6); 7.6852 (6.0); 7.6773 (0.6); 7.6060 (0.5); 7.6013 (0.6); 7.5931 (0.6); 7.5880 (1.0); 7.5850 (0.7); 7.5831 (0.8); 7.5803 (0.7); 7.5752 (0.7); 7.5702 (0.8); 7.5669 (1.0); 7.5620 (0.7); 7.5542 (0.6); 7.5492 (0.6); 7.5212 (0.7); 7.4985 (0.8); 7.4878 (1.0); 7.4846 (1.2); 7.4718 (0.9); 7.4638 (7.3); 7.4584 (2.7); 7.4466 (1.8); 7.4412 (7.0); 7.4332 (0.6); 7.4241 (1.2); 7.4191 (1.0); 7.3991 (1.6); 7.3958 (1.4); 7.3809 (1.3); 7.3779 (1.3); 7.3612 (0.6); 7.3577 (0.6); 5.7537 (16.0); 5.0406 (0.6); 5.0374 (0.6); 4.3596 (0.9); 4.3390 (1.1); 4.3322 (1.3); 4.3117 (1.0); 4.0592 (0.8); 4.0528 (0.8); 4.0316 (0.7); 4.0256 (0.7); 3.4163 (2.1); 3.1549 (0.9); 3.1302 (1.1); 3.1102 (1.4); 3.0855 (1.2); 2.9000 (1.0); 2.8925 (0.9); 2.8554 (0.7); 2.8482 (0.7); 2.6693 (0.6); 2.5228 (1.3); 2.5181 (2.0); 2.5094 (28.9); 2.5048 (63.4); 2.5002 (89.4); 2.4956 (61.6); 2.4910 (26.7); 2.4502 (0.5); 2.3270 (0.5); 1.1777 (0.7); 0.0080 (1.5); -0.0002 (61.9); -0.0060 (0.5); -0.0085 (1.8) I.4-63: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.1391 (8.0); 8.1359 (9.6); 8.1327 (8.3); 8.1305 (5.8); 8.0396 (2.3); 8.0340 (2.3); 8.0282 (3.2); 8.0220 (3.3); 8.0158 (3.2); 8.0138 (3.8); 8.0100 (3.2); 8.0017 (2.6); 7.9960 (2.3); 7.9865 (0.5); 7.7700 (0.6); 7.7187 (3.6); 7.7146 (5.1); 7.7112 (3.8); 7.7068 (5.4); 7.7002 (4.1); 7.6987 (4.4); 7.6947 (5.3); 7.6916 (4.3); 7.6881 (4.7); 7.6457 (1.0); 7.6265 (16.0); 7.6244 (14.6); 7.6216 (6.7); 7.6172 (7.4); 7.6143 (13.7); 7.6122 (14.7); 7.5984 (3.9); 7.5933 (5.3); 7.5800 (9.4); 7.5750 (8.7); 7.5613 (8.1); 7.5555 (9.6); 7.5522 (3.6); 7.5438 (5.5); 7.5395 (6.5); 7.5374 (5.4); 7.5333 (5.7); 7.5254 (3.1); 7.5211 (2.7); 7.5190 (3.5); 7.5150 (2.9); 7.5027 (10.7); 7.4982 (8.2); 7.4965 (8.0); 7.4840 (5.7); 7.4785 (4.2); 5.7537 (8.8); 5.0951 (1.5); 5.0896 (1.6); 5.0706 (3.0); 5.0504 (1.8); 4.4234 (2.1); 4.4154 (2.2); 4.4034 (2.6); 4.3953 (5.1); 4.3876 (3.2); 4.3757 (2.4); 4.3674 (2.3); 4.1889 (2.5); 4.1829 (2.6); 4.1613 (2.2); 4.1553 (2.0); 4.0692 (2.4); 4.0634 (2.4); 4.0413 (2.2); 4.0356 (2.1); 3.3107 (139.9); 3.2614 (0.9); 3.2255 (2.2); 3.2073 (2.2); 3.2010 (2.7); 3.1808 (3.8); 3.1624 (3.5); 3.1562 (2.9); 3.1383 (2.8); 3.1144 (0.9); 3.1025 (1.0); 3.0959 (0.8); 3.0845 (0.9); 3.0027 (3.0); 2.9956 (2.9); 2.9579 (2.0); 2.9510 (2.1); 2.8910 (2.8); 2.8842 (2.8); 2.8463 (2.2); 2.8395 (2.2); 2.6740 (2.0); 2.6694 (2.8); 2.6648 (2.0); 2.6601 (0.9); 2.5504 (0.6); 2.5229 (6.2); 2.5182 (9.4); 2.5095 (153.5); 2.5049 (338.6); 2.5003 (478.6); 2.4957 (332.0); 2.4910 (145.7); 2.4552 (2.6); 2.4504 (3.1); 2.4459 (2.2); 2.3317 (2.2); 2.3271 (3.0); 2.3224 (2.1); 2.0725 (1.1); 1.2346 (0.7); 1.1939 (2.6); 1.1757 (5.2); 1.1575 (2.4); 0.1460 (0.8); 0.0126 (0.6); 0.0119 (0.8); 0.0110 (1.0); 0.0103 (1.1); 0.0080 (9.1); 0.0063 (2.5); 0.0055 (2.7); 0.0047 (3.2); 0.0039 (4.1); 0.0022 (11.8); -0.0002 (312.7); -0.0027 (14.3); -0.0035 (9.1); -0.0043 (5.2); -0.0052 (3.7); -0.0060 (3.0); -0.0068 (2.7); -0.0085 (9.0); -0.0107 (1.4); -0.0115 (1.3); -0.0124 (1.1); -0.0132 (1.0); -0.0139 (1.0); -0.0148 (0.9); -0.0155 (0.8); -0.0164 (0.8); -0.0171 (0.6); -0.0179 (0.6); -0.0187 (0.7); -0.0203 (0.6); -0.0211 (0.5); -0.0330 (0.7); - 0.0500 (1.1); -0.1496 (0.9) I.4-64: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 9.7639 (2.7); 8.5660 (1.5); 7.6080 (2.4); 7.6033 (2.9); 7.5951 (2.7); 7.5899 (5.7); 7.5851 (4.0); 7.5823 (3.7); 7.5773 (3.4); 7.5722 (4.1); 7.5689 (6.1); 7.5640 (3.8); 7.5563 (3.4); 7.5513 (3.4); 7.4964 (2.7); 7.4898 (7.7); 7.4850 (12.4); 7.4791 (12.4); 7.4687 (5.9); 7.4642 (11.2); 7.4595 (16.0); 7.4537 (13.5); 7.4429 (6.6); 7.4390 (9.5); 7.4341 (6.9); 7.4211 (7.1); 7.4158 (6.0); 7.4007 (10.1); 7.3975 (8.7); 7.3827 (7.9); 7.3795 (7.8); 7.3629 (3.7); 7.3594 (3.6); 7.0539 (2.4); 7.0482 (4.2); 7.0425 (2.1); 7.0308 (5.2); 7.0251 (8.3); 7.0193 (3.9); 7.0079 (2.5); 7.0019 (4.1); 6.9961 (1.9); 5.7537 (3.1); 5.0613 (2.9); 5.0550 (2.1); 5.0409 (4.3); 5.0372 (4.1); 5.0226 (2.1); 5.0165 (2.9); 4.3656 (5.6); 4.3452 (6.5); 4.3376 (7.7); 4.3175 (5.9); 4.0760 (5.0); 4.0708 (4.9); 4.0480 (4.3); 3.3160 (188.2); 3.2660 (1.8); 3.2178 (5.6); 3.1931 (6.5); 3.1727 (8.0); 3.1481 (6.7); 2.9215 (5.4); 2.9150 (5.4); 2.8764 (4.2); 2.8699 (4.1); 2.6740 (3.5); 2.6694 (5.0); 2.6647 (3.4); 2.6602 (1.6); 2.5229 (12.2); 2.5182 (18.1); 2.5095 (260.3); 2.5049 (570.0); 2.5003 (804.0); 2.4956 (554.9); 2.4910 (247.1); 2.4549 (4.4); 2.4502 (5.6); 2.4458 (4.2); 2.3318 (3.6); 2.3271 (4.8); 2.3224 (3.5); 2.0724 (1.8); 1.1762 (1.0); 0.1458 (1.3); 0.0126 (1.0); 0.0118 (1.1); 0.0080 (15.7); 0.0063 (4.1); 0.0055 (4.4); 0.0046 (5.5); 0.0038 (7.4); 0.0022 (21.1); -0.0002 (556.5); -0.0028 (22.8); -0.0035 (14.4); -0.0044 (8.4); -0.0052 (6.3); -0.0060 (5.2); -0.0068 (4.5); -0.0085 (15.9); -0.0108 (2.4); -0.0116 (2.1); -0.0124 (1.9); -0.0132 (1.6); -0.0140 (1.5); -0.0148 (1.4); -0.0156 (1.2); -0.0164 (0.9); -0.0172 (1.0); -0.0180 (0.9); -0.0188 (0.9); -0.0291 (0.9); -0.0503 (2.7); -0.1495 (1.5) I.4-65: 1H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.0516 (3.6); 8.0459 (3.6); 7.7469 (3.5); 7.5139 (2.5); 7.5082 (2.8); 7.4884 (2.9); 7.4827 (2.4); 7.3064 (1.8); 7.2899 (1.8); 7.1473 (2.3); 7.1458 (2.3); 7.1270 (2.7); 7.1256 (2.7); 7.0415 (0.6); 7.0357 (1.0); 7.0183 (1.2); 7.0126 (2.1); 7.0068 (1.0); 6.9951 (0.7); 6.9894 (1.1); 6.9218 (2.4); 6.9161 (2.3); 6.9016 (2.0); 6.8960 (1.9); 4.4119 (0.5); 4.4041 (0.7); 4.3948 (0.8); 4.3862 (0.8); 4.3782 (0.6); 4.1589 (1.5); 4.1426 (1.6); 4.1330 (1.9); 4.1168 (1.4); 3.7256 (1.3); 3.7171 (1.3); 3.6998 (1.2); 3.6915 (1.2); 3.3159 (263.8); 3.2654 (1.6); 3.0415 (1.5); 3.0219 (1.7); 2.9987 (1.9); 2.9792 (1.7); 2.6746 (0.6); 2.6700 (0.9); 2.6655 (0.6); 2.5235 (1.7); 2.5188 (2.6); 2.5101 (47.1); 2.5055 (104.4); 2.5009 (147.8); 2.4963 (103.2); 2.4916 (45.6); 2.4755 (2.0); 2.4553 (0.8); 2.4506 (1.1); 2.4425 (1.6); 2.4325 (1.4); 2.3323 (0.7); 2.3277 (0.9); 2.3230 (0.7); 2.1402 (16.0); 2.0727 (0.6); 1.1771 (0.8); 0.0081 (1.5); -0.0002 (53.9); -0.0085 (1.5) I.4-66: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.1051 (2.4); 8.0995 (2.4); 8.0591 (3.6); 8.0535 (3.4); 7.8691 (3.6); 7.7495 (2.8); 7.7436 (3.2); 7.7373 (2.9); 7.7317 (1.6); 7.7263 (2.8); 7.7216 (3.7); 7.7141 (2.9); 7.7093 (3.6); 7.7041 (1.8); 7.6984 (3.7); 7.6918 (1.1); 7.6860 (3.5); 7.2549 (2.7); 7.2489 (1.1); 7.2431 (4.2); 7.2372 (2.3); 7.2318 (5.2); 7.2273 (3.4); 7.2213 (6.2); 7.2158 (3.3); 7.2102 (3.7); 7.2044 (2.2); 7.1984 (3.9); 7.1592 (2.4); 7.1375 (4.3); 7.1173 (1.9); 6.9292 (2.4); 6.9236 (2.3); 6.9090 (2.1); 6.9039 (2.6); 6.8997 (1.7); 6.8850 (1.4); 6.8795 (1.4); 4.5174 (0.6); 4.5035 (0.7); 4.1284 (1.0); 4.1149 (1.2); 4.1025 (2.2); 4.0888 (1.3); 4.0841 (2.7); 4.0674 (2.6); 4.0554 (1.2); 4.0380 (0.8); 3.6312 (1.2); 3.6268 (1.1); 3.6007 (1.5); 3.5861 (1.7); 3.5797 (1.8); 3.3113 (250.1); 3.2811 (0.5); 3.2785 (0.7); 3.2618 (1.6); 3.1107 (1.6); 3.0988 (1.7); 3.0925 (1.7); 3.0804 (1.6); 3.0623 (0.5); 2.9801 (1.2); 2.9624 (1.6); 2.9445 (1.1); 2.6743 (1.3); 2.6696 (1.8); 2.6650 (1.3); 2.6165 (1.0); 2.5986 (1.3); 2.5786 (1.1); 2.5231 (3.8); 2.5184 (5.8); 2.5098 (97.6); 2.5052 (215.8); 2.5005 (302.6); 2.4959 (211.6); 2.4913 (94.1); 2.4552 (2.0); 2.4507 (2.4); 2.4461 (1.8); 2.4004 (0.5); 2.3319 (1.4); 2.3273 (1.9); 2.3227 (1.3); 2.2555 (1.6); 2.1703 (16.0); 2.1319 (11.1); 2.0725 (2.5); 1.2243 (11.0); 1.2065 (10.8); 1.1964 (4.3); 1.1782 (8.6); 1.1600 (4.0); 1.1140 (6.9); 1.0957 (6.8); 0.0080 (3.1); 0.0055 (0.8); -0.0002 (116.9); -0.0068 (1.3); -0.0085 (3.5); -0.0499 (0.7) I.4-67: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 9.2529 (0.5); 8.1767 (2.9); 8.1726 (3.1); 8.1588 (4.3); 8.1562 (5.3); 8.1520 (3.6); 7.7285 (1.9); 7.7122 (1.9); 7.5637 (0.6); 7.5573 (5.8); 7.5525 (1.8); 7.5409 (1.9); 7.5360 (6.6); 7.5295 (0.7); 7.3449 (0.8); 7.3416 (1.0); 7.3310 (1.4); 7.2920 (2.0); 7.2717 (4.8); 7.2512 (3.7); 7.2244 (4.6); 7.2203 (5.3); 7.2043 (3.1); 7.2002 (3.0); 7.1950 (4.8); 7.1746 (4.3); 7.0247 (0.6); 7.0045 (1.1); 6.9845 (0.9); 6.7524 (0.7); 6.7488 (1.2); 6.7350 (1.3); 6.7315 (1.4); 6.7281 (1.0); 6.7155 (1.1); 6.7119 (0.8); 5.6679 (0.7); 4.3999 (0.6); 4.3922 (0.8); 4.3832 (0.9); 4.3744 (0.8); 4.3658 (0.6); 4.1569 (1.8); 4.1410 (1.9); 4.1312 (2.2); 4.1154 (1.7); 3.6661 (1.6); 3.6581 (1.5); 3.6404 (1.4); 3.6325 (1.4); 3.3147 (96.5); 3.0905 (0.9); 3.0730 (0.9); 2.9805 (1.7); 2.9612 (1.9); 2.9382 (2.1); 2.9188 (1.9); 2.5241 (1.0); 2.5194 (1.5); 2.5108 (19.9); 2.5062 (42.7); 2.5016 (59.1); 2.4970 (40.8); 2.4924 (18.0); 2.4086 (1.6); 2.3989 (1.5); 2.3662 (1.4); 2.3567 (1.4); 2.2805 (16.0); 1.2332 (0.6); 1.2011 (3.3); 1.1829 (6.9); 1.1646 (3.3) I.4-68: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 9.0261 (0.6); 8.2185 (2.1); 8.2119 (2.0); 8.1713 (0.7); 8.1147 (1.1); 8.1104 (1.1); 8.0939 (2.2); 8.0897 (2.1); 8.0732 (1.2); 8.0690 (1.1); 7.5484 (5.6); 7.5435 (1.8); 7.5318 (2.0); 7.5270 (6.4); 7.2352 (0.5); 7.2151 (0.7); 7.2017 (2.2); 7.1930 (6.0); 7.1764 (3.0); 7.1714 (4.9); 7.1641 (2.0); 7.1471 (1.9); 7.1435 (2.0); 7.1018 (1.0); 7.0828 (1.9); 7.0634 (1.1); 6.9661 (0.9); 6.9617 (0.9); 6.9531 (1.0); 6.9488 (1.2); 6.9414 (0.9); 6.9303 (1.0); 6.9227 (0.6); 6.9142 (0.5); 6.9098 (0.5); 4.3963 (0.6); 4.3884 (0.9); 4.3790 (0.9); 4.3706 (0.9); 4.1415 (1.8); 4.1253 (1.9); 4.1161 (2.2); 4.0999 (1.8); 3.6542 (1.6); 3.6456 (1.6); 3.6287 (1.4); 3.6202 (1.4); 3.3111 (267.5); 3.2612 (0.7); 2.9559 (1.8); 2.9364 (2.0); 2.9137 (2.2); 2.8942 (1.9); 2.6744 (0.7); 2.6697 (1.0); 2.6652 (0.8); 2.5230 (3.1); 2.5183 (4.7); 2.5097 (60.6); 2.5051 (130.2); 2.5005 (180.0); 2.4959 (124.1); 2.4913 (54.8); 2.4062 (1.7); 2.3958 (1.7); 2.3641 (1.5); 2.3534 (1.4); 2.3320 (0.8); 2.3274 (1.1); 2.3227 (0.7); 2.2791 (16.0); 1.9876 (0.8); 1.1922 (1.0); 1.1744 (2.0); 1.1564 (0.9); -0.0002 (1.1) I.4-69: 1 H-NMR (400.0 MHz, CDCl3): δ= 7.5179 (3.2); 7.4518 (5.0); 7.4306 (5.7); 7.3244 (0.6); 7.3123 (0.6); 7.2590 (577.6); 7.2324 (0.8); 7.2168 (1.0); 7.2100 (1.5); 7.1960 (2.0); 7.1709 (4.6); 7.1504 (3.8); 6.9950 (3.3); 6.9848 (3.5); 6.9650 (4.4); 6.9444 (2.3); 5.9592 (1.7); 5.1915 (1.0); 4.6158 (0.9); 4.2085 (2.0); 4.1928 (1.9); 4.1820 (2.4); 4.1663 (2.2); 3.8132 (1.9); 3.8054 (1.7); 3.7870 (1.6); 3.7790 (1.4); 3.0463 (1.7); 3.0264 (1.9); 3.0030 (2.2); 2.9828 (2.0); 2.4950 (1.6); 2.4852 (1.6); 2.4517 (1.4); 2.4421 (1.4); 2.3208 (16.0); 1.5350 (211.8); 1.4859 (0.6); 1.4214 (1.0); 1.4032 (1.8); 1.3849 (0.8); 0.1459 (0.8); 0.0079 (8.3); -0.0002 (221.0); -0.0085 (6.8); -0.1496 (0.8) I.4-70: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.8196 (1.9); 7.8016 (2.1); 7.6177 (3.3); 7.5239 (0.5); 7.5123 (2.5); 7.5065 (2.8); 7.4867 (2.9); 7.4811 (2.4); 7.1358 (1.8); 7.1246 (2.1); 7.1193 (1.9); 7.1078 (2.6); 7.0904 (1.7); 7.0708 (1.0); 7.0386 (0.6); 7.0328 (1.0); 7.0271 (0.5); 7.0154 (1.2); 7.0096 (2.0); 7.0038 (1.0); 6.9923 (0.6); 6.9864 (1.0); 6.9016 (1.3); 6.8986 (1.3); 6.8831 (2.2); 6.8801 (2.1); 6.8645 (0.9); 6.8615 (0.9); 4.4116 (0.6); 4.4039 (0.8); 4.3948 (0.8); 4.3856 (0.8); 4.3782 (0.6); 4.1520 (1.5); 4.1356 (1.6); 4.1262 (1.9); 4.1099 (1.5); 3.7125 (1.4); 3.7040 (1.4); 3.6868 (1.2); 3.6783 (1.2); 3.3136 (102.1); 3.2631 (0.8); 3.0262 (1.6); 3.0065 (1.7); 2.9834 (2.0); 2.9638 (1.7); 2.6697 (0.7); 2.6650 (0.5); 2.5232 (1.6); 2.5185 (2.5); 2.5098 (41.2); 2.5052 (90.7); 2.5006 (127.1); 2.4960 (89.5); 2.4914 (40.2); 2.4751 (2.0); 2.4551 (1.0); 2.4505 (1.3); 2.4427 (1.7); 2.4323 (1.4); 2.3320 (0.6); 2.3274 (0.8); 2.3227 (0.6); 2.1611 (16.0); 1.1949 (0.8); 1.1766 (1.6); 1.1586 (0.8); 0.0080 (1.7); -0.0002 (62.2); -0.0068 (0.8); -0.0085 (2.0) I.4-71: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.1645 (8.0); 8.1606 (8.2); 8.1436 (8.9); 8.1397 (8.6); 8.0370 (12.3); 7.6441 (6.1); 7.6280 (5.9); 7.5028 (3.2); 7.4985 (3.8); 7.4830 (6.9); 7.4789 (7.2); 7.4634 (4.1); 7.4592 (4.3); 7.4188 (9.1); 7.4152 (9.4); 7.3988 (10.1); 7.3951 (10.0); 7.3739 (1.0); 7.3645 (1.7); 7.3573 (3.6); 7.3530 (3.6); 7.3470 (2.7); 7.3402 (10.7); 7.3370 (6.7); 7.3344 (7.3); 7.3264 (5.0); 7.3221 (4.4); 7.3127 (5.3); 7.3084 (7.1); 7.2920 (2.6); 7.2874 (1.8); 7.2742 (6.3); 7.2682 (7.5); 7.2645 (4.5); 7.2571 (6.5); 7.2548 (5.9); 7.2500 (8.7); 7.2476 (8.3); 7.2378 (5.3); 7.2323 (3.6); 7.2291 (4.6); 7.2253 (4.2); 6.9886 (6.6); 6.9846 (6.8); 6.9701 (7.0); 6.9686 (6.8); 6.9662 (6.9); 6.9646 (6.8); 6.9501 (5.6); 6.9462 (5.4); 4.4508 (2.0); 4.4436 (2.7); 4.4349 (3.2); 4.4254 (2.7); 4.4188 (2.2); 4.1185 (4.5); 4.1024 (4.5); 4.0947 (5.4); 4.0788 (4.5); 4.0559 (1.2); 4.0381 (3.0); 4.0204 (3.1); 4.0025 (1.1); 3.6109 (5.0); 3.6021 (4.9); 3.5862 (4.7); 3.5772 (4.6); 3.3980 (0.7); 3.3658 (2.5); 3.3165 (697.7); 3.2857 (1.5); 3.2663 (6.6); 3.2159 (1.0); 3.1128 (1.8); 3.1008 (1.9); 3.0946 (2.1); 3.0825 (1.9); 3.0644 (0.6); 2.9360 (6.1); 2.9164 (6.7); 2.8935 (7.6); 2.8740 (6.6); 2.6745 (2.7); 2.6699 (3.8); 2.6652 (2.7); 2.5886 (0.7); 2.5444 (3.6); 2.5234 (10.0); 2.5187 (13.8); 2.5100 (198.0); 2.5054 (436.7); 2.5008 (616.8); 2.4962 (434.7); 2.4916 (196.9); 2.4557 (5.1); 2.4511 (7.1); 2.4465 (5.8); 2.3704 (5.8); 2.3597 (5.7); 2.3277 (8.6); 2.3230 (3.6); 2.3176 (5.8); 2.0727 (2.4); 1.9880 (14.6); 1.9083 (16.0); 1.1954 (3.7); 1.1923 (4.8); 1.1772 (7.7); 1.1746 (9.5); 1.1589 (3.8); 1.1568 (5.1); 0.1462 (0.8); 0.0080 (7.5); 0.0064 (2.0); 0.0055 (2.2); 0.0047 (2.8); -0.0002 (258.2); -0.0067 (4.0); -0.0085 (8.2); - 0.0499 (1.8); -0.1498 (0.8) I.4-72: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.1972 (3.7); 8.1933 (3.7); 8.1763 (4.0); 8.1724 (3.9); 8.1675 (2.9); 8.1637 (3.1); 8.1467 (3.2); 8.1429 (3.2); 8.0904 (4.7); 8.0344 (5.4); 7.7455 (5.4); 7.7396 (1.8); 7.7332 (6.0); 7.7276 (3.1); 7.7222 (6.3); 7.7180 (5.0); 7.7099 (6.2); 7.7057 (5.0); 7.7004 (2.6); 7.6948 (5.0); 7.6883 (1.5); 7.6824 (4.7); 7.5243 (2.0); 7.5083 (2.0); 7.4937 (2.8); 7.4725 (2.7); 7.4238 (3.5); 7.4202 (3.5); 7.4034 (4.7); 7.4019 (5.2); 7.3986 (5.4); 7.3819 (4.5); 7.3783 (4.7); 7.2733 (1.7); 7.2698 (1.7); 7.2638 (2.4); 7.2598 (2.5); 7.2559 (7.7); 7.2505 (3.8); 7.2431 (8.3); 7.2387 (4.5); 7.2343 (10.1); 7.2211 (8.3); 7.2171 (2.7); 7.2113 (6.0); 7.2042 (1.6); 7.1984 (4.5); 6.9962 (2.5); 6.9922 (2.7); 6.9777 (2.9); 6.9762 (2.8); 6.9737 (5.4); 6.9696 (3.5); 6.9578 (2.6); 6.9551 (3.7); 6.9537 (5.1); 6.9512 (3.3); 6.9497 (3.4); 6.9352 (2.7); 6.9312 (2.6); 5.7535 (1.3); 4.5401 (0.7); 4.5238 (1.4); 4.5096 (1.5); 4.4924 (0.7); 4.1283 (2.4); 4.1147 (2.7); 4.1071 (1.6); 4.1024 (3.3); 4.0888 (5.6); 4.0770 (1.9); 4.0710 (3.2); 4.0563 (1.9); 4.0383 (2.7); 4.0205 (2.2); 4.0026 (0.7); 3.6300 (2.7); 3.6255 (2.8); 3.6040 (2.7); 3.5994 (3.0); 3.5836 (2.4); 3.5772 (2.4); 3.5646 (0.7); 3.4000 (0.8); 3.3657 (2.5); 3.3510 (1.1); 3.3486 (1.4); 3.3169 (717.5); 3.2888 (1.3); 3.2835 (1.0); 3.2667 (5.7); 3.2553 (0.9); 3.2164 (1.0); 3.1983 (0.6); 2.9942 (0.7); 2.9760 (2.7); 2.9581 (3.6); 2.9404 (2.6); 2.9226 (0.6); 2.6747 (1.4); 2.6702 (2.0); 2.6655 (1.5); 2.6028 (1.5); 2.5847 (2.1); 2.5649 (1.4); 2.5505 (1.8); 2.5236 (5.8); 2.5190 (8.2); 2.5103 (108.8); 2.5057 (238.6); 2.5010 (336.1); 2.4964 (232.6); 2.4918 (101.4); 2.4557 (2.6); 2.4511 (3.1); 2.4464 (2.2); 2.4006 (0.7); 2.3325 (1.6); 2.3278 (2.1); 2.3232 (1.5); 1.9881 (10.2); 1.9085 (2.2); 1.2267 (14.8); 1.2088 (14.3); 1.1925 (3.4); 1.1746 (6.5); 1.1569 (3.1); 1.1133 (16.0); 1.0950 (15.8); 0.8755 (0.6); 0.8583 (2.7); 0.8406 (0.8); -0.0002 (19.2); -0.0085 (0.6) I.4-73: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.2316 (10.1); 8.2259 (10.1); 8.1741 (0.6); 8.1068 (5.1); 8.1026 (5.5); 8.0860 (10.6); 8.0819 (10.7); 8.0653 (6.0); 8.0613 (5.6); 7.5221 (1.4); 7.5151 (2.5); 7.5035 (13.5); 7.4978 (15.6); 7.4780 (16.0); 7.4723 (13.4); 7.4669 (3.0); 7.4606 (2.5); 7.4535 (1.5); 7.2010 (8.3); 7.1973 (14.2); 7.1805 (15.0); 7.1776 (13.6); 7.1720 (7.3); 7.1684 (7.2); 7.1516 (7.1); 7.1480 (7.8); 7.1029 (4.6); 7.0869 (9.3); 7.0669 (5.8); 7.0381 (3.3); 7.0323 (5.6); 7.0266 (2.9); 7.0150 (6.4); 7.0092 (10.9); 7.0034 (5.5); 6.9918 (3.6); 6.9860 (5.7); 6.9804 (2.8); 6.9726 (4.7); 6.9683 (4.8); 6.9598 (5.0); 6.9554 (6.1); 6.9481 (4.9); 6.9410 (5.3); 6.9367 (5.3); 6.9293 (3.1); 6.9208 (3.0); 6.9165 (2.9); 4.4292 (1.6); 4.4198 (2.8); 4.4121 (4.1); 4.4030 (4.6); 4.3942 (4.2); 4.3863 (3.0); 4.3765 (2.1); 4.1531 (8.5); 4.1366 (8.9); 4.1274 (10.8); 4.1109 (8.3); 4.0383 (1.4); 4.0205 (1.3); 3.7144 (7.5); 3.7054 (7.5); 3.6887 (7.0); 3.6797 (6.8); 3.3623 (3.4); 3.3462 (0.8); 3.3403 (0.7); 3.3121 (330.1); 3.2858 (1.9); 3.2791 (0.8); 3.2624 (5.7); 3.2130 (0.6); 3.1941 (0.7); 3.0230 (8.8); 3.0032 (9.4); 2.9802 (10.9); 2.9605 (9.8); 2.6746 (2.0); 2.6700 (2.9); 2.6653 (2.1); 2.5557 (3.3); 2.5510 (4.9); 2.5464 (3.4); 2.5289 (0.8); 2.5236 (6.1); 2.5188 (9.0); 2.5101 (156.2); 2.5055 (346.7); 2.5009 (491.5); 2.4963 (348.4); 2.4917 (160.0); 2.4746 (14.2); 2.4603 (5.2); 2.4558 (7.9); 2.4512 (10.0); 2.4464 (8.3); 2.4423 (11.1); 2.4317 (8.6); 2.4010 (1.6); 2.3818 (1.5); 2.3324 (2.4); 2.3277 (3.3); 2.3230 (2.4); 2.0730 (2.1); 1.9881 (6.4); 1.9085 (6.7); 1.2333 (0.8); 1.1925 (2.0); 1.1748 (4.0); 1.1569 (2.1); 0.1460 (0.8); 0.0499 (2.2); 0.0081 (7.6); -0.0002 (282.6); -0.0086 (9.1); -0.0500 (4.0); -0.1198 (0.6); -0.1495 (0.8) I.4-74: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.1649 (2.9); 8.1611 (3.2); 8.1571 (2.1); 8.1547 (3.7); 8.1517 (3.7); 8.1496 (3.0); 8.1481 (3.1); 8.1462 (2.8); 8.1442 (3.5); 8.1403 (3.1); 8.0510 (1.7); 8.0451 (1.6); 8.0416 (1.7); 8.0366 (1.8); 8.0347 (1.8); 8.0319 (1.6); 8.0273 (1.9); 8.0214 (1.8); 7.9901 (4.4); 7.6480 (2.0); 7.6316 (2.0); 7.6213 (0.8); 7.6180 (0.7); 7.6113 (7.8); 7.6092 (6.2); 7.6021 (3.6); 7.5988 (3.9); 7.5968 (4.2); 7.5952 (3.9); 7.4108 (3.2); 7.4073 (3.4); 7.3908 (3.5); 7.3871 (3.5); 7.2686 (1.4); 7.2649 (1.4); 7.2500 (1.9); 7.2471 (2.4); 7.2443 (1.6); 7.2294 (1.6); 7.2256 (1.5); 6.9866 (2.4); 6.9827 (2.5); 6.9682 (2.5); 6.9667 (2.4); 6.9643 (2.5); 6.9627 (2.5); 6.9482 (2.0); 6.9442 (2.0); 4.4328 (0.6); 4.4249 (0.9); 4.4162 (1.0); 4.4070 (0.9); 4.3993 (0.7); 4.2080 (1.9); 4.1919 (2.0); 4.1823 (2.4); 4.1663 (1.8); 4.0562 (1.1); 4.0384 (3.3); 4.0206 (3.4); 4.0028 (1.1); 3.7616 (1.7); 3.7533 (1.7); 3.7361 (1.6); 3.7277 (1.6); 3.4674 (4.6); 3.1187 (0.5); 3.1067 (0.6); 3.1004 (1.7); 3.0884 (1.7); 3.0822 (1.7); 3.0702 (1.8); 3.0641 (0.6); 3.0520 (0.6); 3.0376 (2.0); 3.0181 (2.2); 2.9949 (2.4); 2.9754 (2.1); 2.6706 (0.6); 2.5516 (0.6); 2.5469 (0.5); 2.5241 (1.4); 2.5194 (2.1); 2.5107 (33.0); 2.5061 (73.2); 2.5015 (103.9); 2.4969 (72.4); 2.4923 (32.0); 2.4773 (2.4); 2.4671 (2.1); 2.4608 (0.8); 2.4560 (1.0); 2.4515 (1.4); 2.4468 (1.1); 2.4345 (1.7); 2.4245 (1.7); 2.3283 (0.7); 1.9883 (16.0); 1.9090 (10.5); 1.2022 (3.2); 1.1926 (5.0); 1.1841 (7.0); 1.1748 (9.8); 1.1658 (3.2); 1.1570 (4.6); 0.0080 (1.4); 0.0038 (0.6); -0.0002 (48.0); -0.0052 (0.6); -0.0060 (0.5); -0.0085 (1.4) I.4-75: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.2925 (10.6); 8.2865 (10.4); 8.1686 (1.2); 8.1208 (5.6); 8.1167 (5.6); 8.1001 (11.2); 8.0959 (11.0); 8.0795 (6.3); 8.0751 (5.6); 7.4949 (5.3); 7.4913 (6.0); 7.4755 (11.0); 7.4715 (11.5); 7.4560 (6.4); 7.4517 (6.7); 7.3772 (1.9); 7.3730 (1.6); 7.3636 (2.5); 7.3595 (3.6); 7.3564 (5.9); 7.3522 (5.9); 7.3463 (3.9); 7.3388 (16.0); 7.3331 (11.2); 7.3256 (7.8); 7.3213 (7.1); 7.3179 (3.7); 7.3111 (8.7); 7.3069 (10.9); 7.2905 (4.0); 7.2860 (3.0); 7.2724 (9.8); 7.2681 (6.1); 7.2554 (10.2); 7.2530 (8.7); 7.2500 (8.3); 7.2359 (9.0); 7.2305 (5.8); 7.2211 (10.1); 7.2092 (9.5); 7.2054 (15.3); 7.1889 (7.5); 7.1853 (7.7); 7.1801 (6.5); 7.1765 (6.8); 7.1596 (7.4); 7.1561 (7.8); 7.1062 (4.8); 7.0872 (9.6); 7.0673 (5.9); 6.9720 (4.7); 6.9677 (5.0); 6.9592 (4.9); 6.9548 (6.1); 6.9475 (4.9); 6.9404 (5.3); 6.9362 (5.3); 6.9286 (2.8); 6.9201 (2.8); 6.9157 (2.6); 5.7537 (1.3); 4.4477 (4.2); 4.4392 (4.7); 4.4303 (4.5); 4.4230 (3.0); 4.1054 (7.4); 4.0894 (7.5); 4.0807 (8.6); 4.0656 (7.5); 4.0382 (1.4); 4.0203 (1.2); 3.6048 (8.0); 3.5956 (7.8); 3.5800 (7.7); 3.5711 (7.4); 3.3767 (1.4); 3.3658 (8.7); 3.3640 (6.3); 3.3156 (1864.4); 3.2914 (3.7); 3.2830 (3.2); 3.2656 (21.3); 3.2509 (1.9); 3.2333 (3.6); 3.2251 (2.2); 3.2157 (3.2); 2.9178 (9.9); 2.8982 (10.6); 2.8753 (12.4); 2.8558 (10.9); 2.6746 (4.8); 2.6699 (6.5); 2.6654 (4.9); 2.5503 (5.7); 2.5234 (15.7); 2.5187 (22.8); 2.5100 (355.8); 2.5054 (783.2); 2.5008 (1104.3); 2.4962 (771.9); 2.4916 (341.8); 2.4559 (11.2); 2.4513 (14.2); 2.4468 (11.0); 2.4007 (2.6); 2.3727 (10.0); 2.3617 (9.8); 2.3301 (10.7); 2.3230 (6.5); 2.3189 (10.2); 2.0726 (4.7); 1.9880 (5.5); 1.9082 (6.0); 1.1923 (1.7); 1.1746 (3.2); 1.1567 (1.5); 0.0080 (5.1); -0.0002 (188.5); -0.0085 (5.6); -0.0497 (1.4) I.4-76: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.3569 (3.4); 8.2478 (1.3); 8.1606 (0.7); 8.1447 (1.3); 8.1289 (1.7); 8.1244 (2.0); 8.1080 (3.0); 8.1042 (2.8); 8.0874 (1.6); 8.0834 (1.4); 7.6953 (2.9); 7.6835 (5.6); 7.6807 (7.4); 7.6760 (4.8); 7.6616 (6.9); 7.4066 (2.3); 7.3981 (5.0); 7.3848 (3.6); 7.3795 (7.0); 7.3664 (2.4); 7.3580 (4.6); 7.2145 (1.8); 7.2108 (1.8); 7.1903 (2.7); 7.1851 (2.0); 7.1818 (2.0); 7.1611 (4.6); 7.1403 (6.5); 7.1218 (3.9); 7.1128 (3.8); 7.0924 (3.7); 7.0731 (2.0); 7.0611 (0.8); 6.9791 (1.1); 6.9748 (1.2); 6.9662 (1.4); 6.9614 (1.8); 6.9472 (1.9); 6.9272 (1.3); 5.7540 (4.4); 4.5110 (0.7); 4.1309 (1.1); 4.1172 (1.2); 4.1043 (2.3); 4.0856 (4.2); 4.0722 (4.4); 4.0645 (2.8); 4.0465 (1.3); 3.6279 (1.2); 3.6125 (1.2); 3.6016 (1.6); 3.5863 (3.0); 3.5803 (2.8); 3.5546 (0.8); 3.3650 (4.2); 3.3159 (320.3); 3.2651 (4.2); 3.2154 (0.9); 3.1133 (0.9); 3.1011 (1.0); 3.0953 (0.9); 3.0832 (0.9); 2.9755 (1.0); 2.9579 (1.4); 2.9397 (1.0); 2.6743 (1.4); 2.6700 (1.8); 2.6653 (1.4); 2.6302 (0.8); 2.6122 (1.8); 2.5930 (2.7); 2.5746 (2.4); 2.5554 (3.0); 2.5509 (3.9); 2.5462 (3.8); 2.5231 (8.7); 2.5098 (106.4); 2.5054 (213.7); 2.5008 (286.1); 2.4963 (202.7); 2.4918 (93.6); 2.4551 (3.1); 2.4507 (4.2); 2.4462 (3.4); 2.4009 (0.8); 2.3324 (1.4); 2.3275 (1.7); 2.3232 (1.2); 1.2217 (16.0); 1.2039 (15.8); 1.1952 (2.7); 1.1769 (4.0); 1.1587 (1.9); 1.1121 (6.1); 1.0938 (6.0); 0.0501 (0.6); 0.0079 (4.0); - 0.0002 (100.1); -0.0085 (4.0); -0.0501 (1.2) I.4-77: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.1545 (2.8); 8.1509 (2.8); 8.1336 (3.0); 8.1300 (2.8); 7.9750 (4.7); 7.4699 (2.0); 7.4535 (2.0); 7.4090 (2.9); 7.4055 (3.0); 7.3890 (3.1); 7.3855 (3.1); 7.2610 (1.5); 7.2575 (1.4); 7.2398 (2.7); 7.2218 (1.6); 7.2184 (1.4); 6.9795 (1.8); 6.9758 (1.8); 6.9603 (2.6); 6.9568 (2.6); 6.9411 (1.5); 6.9374 (1.4); 4.3754 (1.2); 4.3559 (1.7); 4.3359 (1.1); 4.2484 (1.2); 4.2404 (1.3); 4.2315 (1.2); 3.6412 (2.7); 3.6250 (3.0); 3.6159 (3.4); 3.5997 (3.2); 3.5124 (4.0); 3.1408 (2.2); 3.1323 (2.2); 3.1154 (2.1); 3.1069 (2.2); 3.1006 (1.0); 3.0883 (0.9); 3.0821 (0.9); 3.0697 (0.8); 2.6850 (2.0); 2.6653 (2.5); 2.6432 (2.4); 2.6234 (2.2); 2.5517 (1.0); 2.5102 (33.8); 2.5059 (68.0); 2.5015 (91.7); 2.4970 (67.7); 2.4930 (33.9); 2.4519 (1.7); 2.3284 (0.6); 2.1329 (2.2); 2.1226 (2.3); 2.0911 (2.0); 2.0809 (2.0); 1.9882 (1.1); 1.9087 (16.0); 1.7200 (1.4); 1.6930 (1.6); 1.6719 (1.4); 1.6424 (2.5); 1.6289 (1.7); 1.5292 (3.3); 1.5131 (4.1); 1.2022 (1.4); 1.1840 (2.9); 1.1747 (0.8); 1.1658 (1.4); -0.0002 (10.7) I.4-78: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.2465 (0.7); 8.2403 (0.7); 8.1511 (0.6); 8.1487 (1.1); 8.1457 (1.1); 8.1437 (0.9); 8.1422 (0.9); 8.1405 (0.7); 8.0922 (0.8); 8.0881 (0.8); 8.0421 (0.5); 8.0329 (0.5); 8.0275 (0.6); 8.0260 (0.6); 8.0184 (0.6); 8.0125 (0.5); 7.6082 (2.4); 7.6060 (2.0); 7.5992 (1.1); 7.5959 (1.2); 7.5936 (1.2); 7.5921 (1.2); 7.2279 (0.7); 7.2111 (0.7); 7.1773 (0.5); 7.1482 (0.6); 7.0876 (0.6); 4.1998 (0.6); 4.1834 (0.6); 4.1743 (0.7); 4.1580 (0.6); 3.7542 (0.5); 3.7450 (0.5); 3.3200 (14.1); 3.0193 (0.6); 2.9996 (0.7); 2.9766 (0.8); 2.9570 (0.7); 2.5119 (3.3); 2.5074 (7.2); 2.5027 (10.1); 2.4981 (7.0); 2.4935 (3.1); 2.4861 (0.7); 2.4750 (0.6); 2.4433 (0.5); 2.0743 (16.0); 1.1829 (1.0); -0.0002 (6.2) I.4-79: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.1588 (4.0); 8.1549 (4.0); 8.1379 (4.3); 8.1340 (4.0); 7.9766 (6.2); 7.9149 (6.8); 7.9093 (2.5); 7.8977 (3.6); 7.8920 (16.0); 7.8871 (2.5); 7.8661 (2.9); 7.8613 (15.7); 7.8556 (3.1); 7.8439 (2.4); 7.8384 (6.4); 7.7740 (0.6); 7.6311 (2.8); 7.6142 (2.8); 7.4089 (4.5); 7.4054 (4.8); 7.3889 (5.2); 7.3852 (4.8); 7.2665 (2.1); 7.2632 (1.9); 7.2452 (3.4); 7.2274 (2.4); 7.2237 (2.2); 6.9859 (3.2); 6.9819 (3.3); 6.9674 (3.6); 6.9660 (3.5); 6.9636 (3.4); 6.9620 (3.5); 6.9474 (2.8); 6.9435 (2.6); 4.4245 (1.3); 4.4155 (1.6); 4.4090 (1.4); 4.2145 (2.5); 4.1985 (2.6); 4.1888 (3.2); 4.1729 (2.5); 4.0382 (0.6); 4.0202 (0.7); 3.7600 (2.2); 3.7517 (2.2); 3.7346 (2.1); 3.7261 (2.1); 3.3682 (3.0); 3.3517 (2.0); 3.3196 (489.3); 3.2819 (1.1); 3.2697 (5.3); 3.2375 (0.9); 3.2189 (0.8); 3.1288 (1.0); 3.1164 (1.1); 3.1103 (3.4); 3.0983 (3.4); 3.0920 (3.4); 3.0801 (3.3); 3.0745 (1.1); 3.0619 (1.1); 3.0537 (2.7); 3.0344 (2.9); 3.0109 (3.3); 2.9915 (2.9); 2.6744 (2.2); 2.6698 (3.0); 2.6651 (2.1); 2.5511 (3.1); 2.5462 (3.1); 2.5233 (8.8); 2.5186 (12.3); 2.5099 (163.7); 2.5053 (357.2); 2.5007 (503.5); 2.4961 (351.7); 2.4915 (157.0); 2.4600 (3.1); 2.4556 (5.1); 2.4510 (8.7); 2.4464 (5.7); 2.4414 (4.6); 2.4012 (1.2); 2.3321 (2.3); 2.3275 (3.1); 2.3228 (2.3); 2.0727 (3.8); 1.9879 (3.3); 1.9082 (1.7); 1.1968 (6.3); 1.1923 (1.5); 1.1786 (13.2); 1.1746 (2.9); 1.1604 (6.2); 0.1458 (0.6); 0.0499 (0.5); 0.0080 (6.4); 0.0055 (1.8); -0.0002 (227.1); -0.0085 (7.0); -0.0499 (2.5); -0.1499 (0.8) I.4-80: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.1794 (0.5); 8.1723 (1.8); 8.1684 (1.9); 8.1514 (2.0); 8.1476 (1.9); 8.0939 (2.9); 8.0433 (0.6); 7.7165 (0.6); 7.7137 (0.8); 7.6943 (1.1); 7.6917 (1.3); 7.6884 (2.9); 7.6855 (3.6); 7.6804 (0.9); 7.6687 (1.9); 7.6663 (3.9); 7.6638 (3.3); 7.5425 (1.2); 7.5259 (1.3); 7.4237 (2.1); 7.4201 (2.2); 7.4102 (0.8); 7.4036 (2.8); 7.4003 (5.1); 7.3956 (1.4); 7.3918 (1.0); 7.3879 (1.0); 7.3821 (3.6); 7.3793 (3.3); 7.3701 (0.8); 7.3652 (1.0); 7.3605 (2.8); 7.2739 (1.0); 7.2701 (1.0); 7.2553 (1.3); 7.2524 (1.6); 7.2347 (1.1); 7.2310 (1.0); 7.1632 (1.0); 7.1605 (1.8); 7.1578 (1.1); 7.1421 (2.8); 7.1264 (0.8); 7.1236 (1.3); 7.1209 (0.7); 6.9957 (1.5); 6.9917 (1.6); 6.9772 (1.6); 6.9758 (1.6); 6.9733 (1.6); 6.9718 (1.8); 6.9573 (1.3); 6.9533 (1.5); 4.1237 (1.1); 4.1052 (1.9); 4.0886 (1.3); 4.0831 (1.6); 4.0787 (1.0); 4.0587 (1.0); 4.0412 (0.7); 3.6078 (1.2); 3.5922 (1.5); 3.5855 (1.4); 3.5699 (0.8); 3.3536 (13.4); 3.1092 (0.6); 3.0972 (0.5); 3.0909 (0.6); 3.0789 (0.6); 2.6701 (0.5); 2.6096 (1.1); 2.5916 (1.4); 2.5718 (1.0); 2.5520 (0.6); 2.5236 (1.2); 2.5189 (1.8); 2.5102 (26.2); 2.5056 (57.2); 2.5010 (80.1); 2.4964 (55.8); 2.4918 (24.7); 2.4557 (0.8); 2.4512 (1.1); 2.4466 (0.8); 1.9881 (0.9); 1.9086 (16.0); 1.2325 (9.3); 1.2146 (9.0); 1.1968 (1.1); 1.1786 (2.2); 1.1746 (0.7); 1.1604 (1.0); 1.1192 (1.8); 1.1009 (1.8); -0.0002 (15.7) I.4-81: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.5863 (1.4); 8.4650 (0.6); 8.0326 (1.1); 8.0245 (1.2); 8.0165 (0.9); 8.0084 (0.9); 8.0042 (1.2); 7.9961 (1.0); 7.9880 (0.8); 7.9800 (0.7); 7.6946 (1.3); 7.6918 (1.6); 7.6828 (3.0); 7.6799 (3.8); 7.6749 (1.8); 7.6727 (1.9); 7.6700 (1.6); 7.6608 (4.1); 7.6582 (3.3); 7.4069 (1.3); 7.3993 (3.0); 7.3941 (1.2); 7.3883 (1.8); 7.3856 (1.8); 7.3808 (3.8); 7.3779 (2.9); 7.3718 (0.7); 7.3666 (1.4); 7.3639 (1.1); 7.3591 (2.8); 7.2746 (0.8); 7.2616 (0.9); 7.2522 (1.1); 7.2471 (1.0); 7.2391 (1.1); 7.2340 (1.0); 7.2244 (1.4); 7.2122 (1.9); 7.1989 (1.8); 7.1629 (1.2); 7.1602 (2.0); 7.1575 (1.1); 7.1417 (3.3); 7.1259 (0.9); 7.1232 (1.4); 6.7894 (0.5); 6.7806 (0.8); 6.7697 (0.7); 6.7664 (0.7); 6.7604 (1.1); 6.7470 (0.7); 6.7380 (1.0); 4.1333 (0.6); 4.1199 (0.6); 4.1078 (1.0); 4.0904 (2.5); 4.0776 (2.1); 4.0707 (1.4); 4.0559 (0.7); 4.0382 (0.9); 4.0204 (0.9); 3.6386 (0.6); 3.6335 (0.6); 3.6164 (0.7); 3.6125 (0.7); 3.6073 (0.7); 3.5904 (1.6); 3.5843 (1.6); 3.3252 (43.8); 3.2422 (0.8); 2.9866 (0.6); 2.9688 (0.8); 2.9512 (0.6); 2.6746 (0.7); 2.6699 (1.0); 2.6653 (0.7); 2.6171 (0.9); 2.5975 (1.2); 2.5791 (0.9); 2.5233 (2.6); 2.5186 (4.0); 2.5100 (53.9); 2.5054 (116.1); 2.5008 (160.7); 2.4961 (111.9); 2.4915 (49.6); 2.4553 (0.8); 2.4507 (1.0); 2.4459 (0.7); 2.3322 (0.7); 2.3275 (1.0); 2.3229 (0.7); 2.0727 (0.6); 1.9880 (4.0); 1.9083 (16.0); 1.2210 (9.4); 1.2032 (9.2); 1.1924 (1.3); 1.1746 (2.3); 1.1568 (1.1); 1.1081 (3.5); 1.0898 (3.4); -0.0002 (10.2) I.4-82: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.4655 (1.6); 8.3876 (1.3); 7.8586 (1.8); 7.8535 (3.4); 7.8484 (1.8); 7.5226 (12.2); 7.5092 (1.9); 7.5024 (16.0); 7.4575 (2.0); 7.4375 (3.0); 7.4170 (1.5); 7.3212 (3.9); 7.3010 (4.3); 7.2807 (2.7); 7.2570 (1.2); 7.2547 (1.4); 7.2520 (1.3); 7.2495 (1.3); 7.2373 (1.1); 7.2349 (1.1); 7.2322 (1.1); 7.2298 (1.0); 5.3101 (5.7); 4.2554 (1.0); 4.2380 (1.3); 4.2273 (1.2); 4.2101 (1.3); 4.0629 (0.5); 4.0442 (0.8); 3.8252 (1.1); 3.8197 (1.0); 3.7971 (1.0); 3.7914 (1.0); 3.3950 (1.5); 3.3767 (5.0); 3.3586 (5.3); 3.3405 (2.1); 3.3148 (180.7); 3.2644 (0.7); 3.0969 (0.8); 3.0780 (3.0); 3.0603 (2.6); 3.0423 (0.8); 3.0325 (1.4); 3.0120 (1.3); 2.6698 (0.5); 2.6072 (1.1); 2.6000 (1.1); 2.5625 (0.9); 2.5557 (1.0); 2.5233 (1.7); 2.5186 (2.3); 2.5100 (34.2); 2.5054 (74.2); 2.5008 (104.1); 2.4962 (73.6); 2.4916 (33.7); 2.3276 (0.6); 1.2509 (4.2); 1.2328 (9.0); 1.2146 (4.3); 1.2091 (3.9); 1.1908 (7.4); 1.1726 (3.4) I.4-83: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.0365 (2.6); 8.0309 (2.6); 7.7443 (2.4); 7.1955 (1.0); 7.1793 (1.0); 7.1444 (1.7); 7.1430 (1.6); 7.1242 (2.0); 7.1227 (2.0); 6.9131 (1.7); 6.9075 (1.7); 6.8932 (1.5); 6.8873 (1.4); 4.2384 (0.6); 4.2293 (0.5); 3.6544 (1.4); 3.6382 (1.6); 3.6289 (1.7); 3.6126 (1.5); 3.4839 (2.2); 3.1887 (1.2); 3.1797 (1.2); 3.1631 (1.2); 3.1543 (1.1); 3.0119 (2.7); 2.9936 (2.9); 2.7097 (1.0); 2.6898 (1.1); 2.6681 (1.4); 2.6481 (1.1); 2.5235 (1.0); 2.5188 (1.5); 2.5101 (24.6); 2.5055 (54.4); 2.5009 (77.1); 2.4962 (53.7); 2.4916 (23.7); 2.4510 (0.6); 2.1581 (1.2); 2.1427 (11.8); 2.1165 (1.0); 2.1057 (1.0); 1.9879 (0.6); 1.9083 (16.0); 1.8717 (0.7); 1.8549 (0.9); 1.8381 (0.7); 1.1992 (0.5); 1.1810 (1.1); 1.1628 (0.5); 0.8500 (8.4); 0.8340 (13.0); 0.8181 (8.2); 0.0081 (1.5); 0.0040 (0.6); 0.0024 (1.9); -0.0002 (56.1); -0.0050 (0.8); -0.0058 (0.7); -0.0066 (0.6); -0.0085 (1.6) I.4-84: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.4504 (2.0); 8.0164 (1.2); 8.0083 (1.2); 8.0001 (1.2); 7.9921 (1.2); 7.9880 (1.2); 7.9801 (1.0); 7.9716 (1.2); 7.9637 (1.0); 7.2598 (1.3); 7.2468 (1.3); 7.2372 (1.4); 7.2322 (1.4); 7.2242 (1.4); 7.2192 (1.4); 7.2095 (1.3); 7.1966 (1.2); 7.1501 (1.9); 7.1331 (1.8); 6.7718 (0.8); 6.7630 (1.2); 6.7544 (0.9); 6.7519 (1.0); 6.7492 (0.8); 6.7428 (1.5); 6.7346 (0.9); 6.7293 (0.7); 6.7206 (1.0); 6.7121 (0.6); 4.3677 (1.0); 4.3488 (1.5); 4.3282 (0.9); 4.2592 (0.7); 4.2513 (1.0); 4.2427 (1.1); 4.2335 (0.9); 4.2259 (0.7); 3.6398 (2.1); 3.6234 (2.3); 3.6142 (2.6); 3.5981 (2.3); 3.4492 (10.8); 3.1318 (2.0); 3.1233 (2.3); 3.1058 (3.4); 3.0976 (2.0); 3.0936 (2.0); 3.0873 (1.9); 3.0754 (1.8); 3.0692 (0.6); 3.0571 (0.5); 2.6752 (2.9); 2.6699 (1.6); 2.6652 (1.0); 2.6558 (2.4); 2.6338 (2.8); 2.6141 (2.6); 2.5233 (3.4); 2.5187 (5.3); 2.5100 (80.0); 2.5054 (174.8); 2.5008 (243.6); 2.4961 (169.2); 2.4915 (74.7); 2.4555 (1.1); 2.4509 (1.4); 2.4462 (1.0); 2.3322 (1.0); 2.3276 (1.5); 2.3230 (1.0); 2.1319 (2.1); 2.1213 (2.1); 2.0901 (1.9); 2.0796 (1.9); 2.0727 (0.6); 1.9081 (16.0); 1.7032 (1.1); 1.6874 (1.3); 1.6546 (1.6); 1.6418 (1.8); 1.5291 (2.3); 1.5183 (2.6); 1.5121 (2.8); 1.4884 (1.5); 1.4695 (0.9); 1.1994 (3.5); 1.1812 (7.5); 1.1629 (3.5); -0.0002 (14.5) I.4-85: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.2277 (2.5); 8.2219 (2.4); 8.1207 (1.4); 8.1165 (1.5); 8.1000 (2.8); 8.0958 (2.8); 8.0792 (1.6); 8.0750 (1.5); 7.1997 (1.6); 7.1961 (1.7); 7.1793 (1.9); 7.1757 (2.0); 7.1704 (1.6); 7.1668 (1.8); 7.1500 (1.9); 7.1465 (2.1); 7.1009 (1.2); 7.0793 (2.6); 7.0701 (1.9); 7.0623 (2.1); 7.0531 (1.9); 6.9628 (1.2); 6.9585 (1.3); 6.9500 (1.3); 6.9456 (1.6); 6.9442 (1.5); 6.9425 (1.3); 6.9382 (1.3); 6.9312 (1.4); 6.9270 (1.3); 6.9254 (1.3); 6.9195 (0.8); 6.9110 (0.8); 6.9067 (0.8); 4.5204 (1.0); 4.5004 (1.8); 4.4799 (1.0); 4.2656 (0.7); 4.2581 (1.0); 4.2489 (1.1); 4.2397 (1.0); 4.2319 (0.7); 4.0381 (0.7); 4.0203 (0.7); 3.7354 (2.6); 3.7189 (2.8); 3.7101 (3.2); 3.6936 (2.8); 3.5543 (3.9); 3.2685 (2.4); 3.2591 (2.4); 3.2431 (2.2); 3.2340 (2.1); 3.1184 (0.8); 3.1061 (0.8); 3.1001 (2.7); 3.0881 (2.7); 3.0819 (2.8); 3.0699 (2.7); 3.0636 (0.9); 3.0517 (0.9); 2.6757 (3.1); 2.6699 (1.2); 2.6652 (0.8); 2.6559 (3.0); 2.6339 (3.5); 2.6141 (3.0); 2.5234 (2.3); 2.5187 (3.5); 2.5100 (55.2); 2.5054 (122.4); 2.5008 (172.0); 2.4961 (118.7); 2.4915 (52.0); 2.4563 (0.8); 2.4517 (0.8); 2.3323 (0.7); 2.3275 (1.0); 2.3229 (0.7); 2.1958 (1.0); 2.1895 (1.2); 2.1807 (0.8); 2.1710 (2.0); 2.1650 (1.7); 2.1568 (1.0); 2.1462 (4.2); 2.1349 (3.1); 2.1222 (0.6); 2.1124 (0.6); 2.1040 (2.2); 2.0929 (2.2); 2.0727 (0.7); 2.0329 (0.5); 2.0156 (1.4); 2.0100 (1.1); 1.9996 (1.8); 1.9945 (1.5); 1.9878 (4.6); 1.9804 (1.4); 1.9716 (1.2); 1.9082 (16.0); 1.6679 (0.7); 1.6521 (2.0); 1.6431 (1.5); 1.6387 (1.9); 1.6276 (3.5); 1.6143 (2.0); 1.6030 (1.6); 1.5879 (0.6); 1.2019 (5.3); 1.1923 (1.2); 1.1837 (11.2); 1.1746 (2.3); 1.1654 (5.1); 1.1567 (1.1); 0.0079 (3.3); 0.0063 (0.9); 0.0055 (1.0); 0.0047 (1.2); 0.0038 (1.6); 0.0022 (4.6); -0.0002 (123.2); -0.0027 (5.5); -0.0044 (2.1); -0.0052 (1.5); -0.0060 (1.3); -0.0068 (1.1); -0.0085 (3.6); -0.0108 (0.6); -0.0116 (0.6) I.4-86: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.4560 (1.8); 8.0198 (1.2); 8.0116 (1.2); 8.0033 (1.2); 7.9953 (1.2); 7.9913 (1.2); 7.9831 (1.1); 7.9749 (1.1); 7.9668 (1.0); 7.2604 (1.2); 7.2473 (1.3); 7.2377 (1.4); 7.2328 (1.3); 7.2247 (1.3); 7.2196 (1.3); 7.2101 (1.3); 7.1970 (1.2); 7.1475 (1.8); 7.1308 (1.7); 6.7720 (0.8); 6.7632 (1.2); 6.7547 (0.9); 6.7522 (0.9); 6.7495 (0.8); 6.7430 (1.4); 6.7348 (0.9); 6.7297 (0.8); 6.7208 (1.0); 6.7122 (0.5); 4.2610 (0.7); 4.2528 (1.0); 4.2436 (1.1); 4.2356 (0.9); 4.2269 (0.7); 4.2056 (0.7); 4.1886 (1.7); 4.1716 (2.3); 4.1546 (1.7); 4.1379 (0.6); 3.6049 (2.4); 3.5885 (2.6); 3.5794 (2.9); 3.5631 (2.6); 3.4651 (8.7); 3.1229 (0.6); 3.1117 (2.4); 3.1042 (3.2); 3.0926 (2.0); 3.0864 (3.8); 3.0776 (2.0); 3.0744 (2.2); 3.0682 (0.7); 3.0562 (0.6); 2.6746 (1.0); 2.6675 (2.7); 2.6478 (2.4); 2.6258 (2.8); 2.6061 (2.4); 2.5234 (2.7); 2.5187 (3.9); 2.5100 (72.7); 2.5054 (162.8); 2.5008 (230.4); 2.4962 (161.8); 2.4916 (72.4); 2.4557 (1.6); 2.4510 (1.9); 2.4464 (1.4); 2.4178 (0.6); 2.3323 (1.0); 2.3276 (1.5); 2.3229 (1.1); 2.1265 (2.2); 2.1158 (2.2); 2.0849 (1.9); 2.0738 (1.9); 1.9082 (16.0); 1.1998 (3.6); 1.1816 (7.6); 1.1633 (3.5); 1.0859 (13.4); 1.0689 (14.2); 1.0650 (14.6); 1.0480 (13.5); -0.0002 (15.6) I.4-87: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.8227 (1.7); 7.8025 (2.0); 7.6052 (2.6); 7.1238 (1.5); 7.1054 (2.4); 7.0862 (1.6); 7.0670 (0.9); 7.0028 (1.0); 6.9861 (0.9); 6.8941 (1.2); 6.8911 (1.2); 6.8756 (2.0); 6.8727 (2.0); 6.8572 (0.9); 6.8541 (0.8); 4.5295 (0.6); 4.5054 (1.1); 4.4818 (0.6); 4.2432 (0.7); 4.0380 (0.5); 4.0202 (0.5); 3.7326 (1.6); 3.7161 (1.7); 3.7074 (1.9); 3.6909 (1.6); 3.5247 (3.0); 3.2714 (1.5); 3.2621 (1.5); 3.2462 (1.4); 3.2370 (1.4); 3.1217 (0.5); 3.1096 (0.6); 3.1034 (1.8); 3.0914 (1.9); 3.0852 (1.9); 3.0731 (1.9); 3.0670 (0.6); 3.0549 (0.6); 2.6755 (2.0); 2.6694 (1.0); 2.6647 (0.7); 2.6556 (1.9); 2.6337 (2.2); 2.6137 (1.9); 2.5230 (2.3); 2.5182 (3.4); 2.5096 (49.4); 2.5050 (108.6); 2.5003 (152.4); 2.4957 (105.1); 2.4911 (46.1); 2.4594 (0.5); 2.4547 (1.0); 2.4501 (1.4); 2.4455 (1.0); 2.3318 (0.7); 2.3271 (0.9); 2.3224 (0.8); 2.2665 (2.1); 2.1964 (0.8); 2.1915 (0.8); 2.1648 (16.0); 2.1535 (2.2); 2.1477 (1.6); 2.1425 (2.5); 2.1117 (1.6); 2.1005 (1.5); 2.0174 (0.8); 2.0010 (1.2); 1.9960 (1.0); 1.9877 (3.4); 1.9727 (0.8); 1.9079 (7.6); 1.6534 (1.3); 1.6403 (1.2); 1.6290 (2.3); 1.6159 (1.2); 1.6045 (1.0); 1.1998 (3.6); 1.1922 (0.9); 1.1816 (7.6); 1.1744 (1.7); 1.1633 (3.5); 1.1566 (0.8); 1.1047 (0.7); 0.0080 (2.7); -0.0002 (103.8); -0.0086 (2.9); -0.0504 (0.8) I.4-88: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 9.3388 (0.6); 8.4265 (4.7); 8.0060 (2.6); 7.9981 (2.4); 7.9897 (2.5); 7.9816 (2.7); 7.9698 (2.3); 7.9612 (2.2); 7.9535 (1.8); 7.2577 (2.3); 7.2446 (2.6); 7.2352 (2.8); 7.2299 (2.6); 7.2224 (2.8); 7.2173 (2.5); 7.2076 (2.4); 7.1946 (2.3); 7.1317 (4.5); 7.1150 (4.1); 6.7699 (1.6); 6.7614 (2.5); 6.7506 (2.2); 6.7409 (3.4); 6.7325 (1.8); 6.7188 (2.1); 6.7101 (0.9); 4.2132 (2.4); 4.2039 (2.4); 4.1955 (2.3); 3.5808 (4.4); 3.5641 (4.5); 3.5557 (5.1); 3.5391 (4.4); 3.3110 (75.4); 3.0629 (4.5); 3.0538 (4.2); 3.0380 (3.9); 3.0287 (3.9); 2.6704 (6.5); 2.6506 (5.9); 2.6299 (5.5); 2.6094 (4.6); 2.5563 (3.6); 2.5516 (3.7); 2.5094 (165.2); 2.5051 (313.8); 2.5007 (409.5); 2.4962 (288.6); 2.4918 (134.0); 2.3277 (2.5); 2.1286 (3.8); 2.1168 (3.8); 2.0862 (3.4); 2.0751 (3.3); 1.9881 (1.3); 1.9077 (16.0); 1.2373 (0.6); 1.1749 (0.8); 1.0474 (5.1); 0.7053 (0.7); 0.6917 (1.7); 0.6756 (3.7); 0.6633 (14.9); 0.6470 (13.1); 0.6280 (5.9); 0.6184 (2.2); 0.6032 (1.7); 0.5925 (1.1); 0.0079 (3.5); -0.0002 (77.4); -0.0084 (3.9) I.4-89: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.4503 (1.4); 8.0212 (0.9); 8.0130 (0.9); 8.0048 (0.8); 7.9968 (0.8); 7.9927 (0.8); 7.9846 (0.8); 7.9764 (0.8); 7.9683 (0.7); 7.2606 (0.9); 7.2475 (0.9); 7.2378 (1.0); 7.2329 (1.0); 7.2249 (1.0); 7.2199 (0.9); 7.2103 (0.9); 7.1973 (0.9); 7.1627 (1.3); 7.1464 (1.2); 6.7742 (0.6); 6.7652 (0.8); 6.7568 (0.7); 6.7544 (0.7); 6.7516 (0.6); 6.7452 (1.0); 6.7370 (0.6); 6.7319 (0.5); 6.7227 (0.7); 4.5222 (0.6); 4.4990 (1.1); 4.4786 (0.6); 4.2621 (0.7); 4.2536 (0.8); 4.2447 (0.7); 3.7394 (1.5); 3.7228 (1.6); 3.7139 (1.8); 3.6975 (1.6); 3.4546 (5.8); 3.2719 (1.5); 3.2628 (1.5); 3.2466 (1.4); 3.2376 (1.3); 3.1058 (0.6); 3.0938 (0.7); 3.0875 (0.6); 3.0756 (0.7); 2.6838 (1.6); 2.6747 (0.6); 2.6699 (0.9); 2.6641 (2.0); 2.6419 (2.0); 2.6221 (1.7); 2.5347 (0.5); 2.5235 (1.7); 2.5188 (2.6); 2.5101 (45.4); 2.5055 (101.1); 2.5009 (142.8); 2.4963 (100.1); 2.4916 (44.6); 2.4741 (0.8); 2.4695 (0.7); 2.4601 (0.5); 2.4555 (0.8); 2.4509 (1.1); 2.4465 (0.8); 2.3323 (0.6); 2.3277 (0.9); 2.3230 (0.6); 2.1965 (0.6); 2.1894 (0.7); 2.1715 (1.2); 2.1647 (1.1); 2.1469 (2.6); 2.1361 (2.2); 2.1048 (1.4); 2.0938 (1.4); 2.0727 (0.6); 2.0153 (0.8); 2.0044 (1.0); 1.9995 (1.1); 1.9879 (1.0); 1.9802 (0.9); 1.9699 (0.7); 1.9082 (16.0); 1.6522 (1.2); 1.6388 (1.2); 1.6277 (2.2); 1.6144 (1.2); 1.6031 (1.0); 1.1993 (1.2); 1.1811 (2.6); 1.1629 (1.2); -0.0002 (8.9) I.4-90: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.2307 (2.2); 8.2245 (2.2); 8.1107 (1.3); 8.1065 (1.3); 8.0900 (2.5); 8.0858 (2.4); 8.0692 (1.3); 8.0650 (1.3); 7.1987 (1.4); 7.1951 (1.5); 7.1784 (1.8); 7.1747 (1.8); 7.1694 (1.4); 7.1658 (1.5); 7.1490 (1.8); 7.1454 (1.9); 7.0982 (1.1); 7.0789 (2.3); 7.0652 (1.9); 7.0599 (1.9); 7.0490 (1.8); 6.9614 (1.2); 6.9571 (1.1); 6.9485 (1.2); 6.9441 (1.4); 6.9384 (1.1); 6.9298 (1.2); 6.9256 (1.2); 6.9180 (0.7); 6.9095 (0.7); 6.9053 (0.6); 5.7538 (0.5); 4.2644 (0.7); 4.2569 (0.9); 4.2482 (1.0); 4.2383 (0.9); 4.2316 (0.6); 3.6503 (2.4); 3.6337 (2.5); 3.6247 (2.9); 3.6082 (2.5); 3.4413 (10.6); 3.1802 (2.2); 3.1710 (2.2); 3.1547 (2.0); 3.1456 (2.0); 3.1213 (0.8); 3.1093 (0.9); 3.1030 (2.8); 3.0910 (2.8); 3.0848 (2.8); 3.0728 (2.8); 3.0666 (0.9); 3.0545 (0.8); 3.0474 (0.7); 3.0286 (0.7); 3.0143 (2.8); 2.9962 (4.9); 2.9787 (2.8); 2.9640 (0.7); 2.9454 (0.7); 2.6954 (1.7); 2.6751 (2.3); 2.6698 (1.2); 2.6651 (0.8); 2.6537 (2.1); 2.6337 (1.9); 2.5233 (2.5); 2.5185 (3.7); 2.5099 (58.2); 2.5053 (128.9); 2.5006 (181.2); 2.4960 (125.4); 2.4914 (55.4); 2.4689 (0.8); 2.4599 (0.9); 2.4553 (1.3); 2.4506 (1.6); 2.4460 (1.1); 2.4416 (0.6); 2.3321 (0.8); 2.3275 (1.1); 2.3230 (0.8); 2.1505 (2.0); 2.1396 (2.0); 2.1089 (1.7); 2.0979 (1.7); 2.0726 (1.2); 1.9879 (0.7); 1.9081 (7.4); 1.8854 (0.6); 1.8676 (1.2); 1.8509 (1.6); 1.8341 (1.3); 1.8173 (0.6); 1.2005 (5.5); 1.1822 (11.6); 1.1746 (0.7); 1.1640 (5.3); 0.8483 (14.8); 0.8354 (16.0); 0.8317 (15.8); 0.8188 (14.4); 0.0081 (3.5); 0.0057 (1.0); 0.0049 (1.2); 0.0041 (1.5); -0.0002 (127.2); -0.0057 (1.2); -0.0065 (1.0); -0.0086 (3.5); -0.0503 (1.0) I.4-91: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 7.8069 (1.8); 7.8043 (1.8); 7.7866 (1.9); 7.7840 (1.9); 7.6131 (2.7); 7.1228 (1.6); 7.1028 (2.4); 7.0830 (1.6); 7.0637 (1.0); 7.0184 (1.0); 7.0029 (0.9); 6.8931 (1.2); 6.8900 (1.2); 6.8746 (2.0); 6.8716 (2.0); 6.8563 (0.9); 6.8529 (0.8); 4.2350 (0.7); 3.6422 (2.5); 3.6258 (3.0); 3.6168 (3.5); 3.6005 (3.9); 3.1868 (1.6); 3.1778 (1.6); 3.1615 (1.5); 3.1525 (1.5); 3.1182 (0.7); 3.1062 (0.8); 3.1000 (2.4); 3.0880 (2.4); 3.0818 (2.4); 3.0698 (2.4); 3.0636 (0.8); 3.0513 (0.9); 3.0159 (2.2); 3.0041 (2.3); 2.9971 (2.4); 2.9856 (2.2); 2.6922 (1.3); 2.6724 (1.6); 2.6650 (0.6); 2.6505 (1.5); 2.6305 (1.4); 2.5231 (2.2); 2.5183 (3.3); 2.5097 (43.9); 2.5051 (94.3); 2.5005 (130.8); 2.4959 (90.9); 2.4913 (40.2); 2.4553 (0.9); 2.4507 (1.2); 2.4461 (0.8); 2.3319 (0.6); 2.3273 (0.8); 2.3226 (0.6); 2.2676 (1.6); 2.1618 (16.0); 2.1492 (1.8); 2.1184 (1.2); 2.1072 (1.3); 1.9877 (0.7); 1.9080 (5.8); 1.8708 (0.9); 1.8539 (1.2); 1.8370 (0.9); 1.2015 (4.8); 1.1833 (10.1); 1.1745 (0.6); 1.1651 (4.7); 0.8504 (10.5); 0.8359 (12.8); 0.8340 (12.6); 0.8196 (10.1); 0.0080 (2.3); -0.0002 (80.5); -0.0086 (2.5); -0.0500 (0.8) I.4-92: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.4647 (1.2); 8.0111 (0.7); 8.0029 (0.7); 7.9946 (0.7); 7.9867 (0.7); 7.9825 (0.7); 7.9745 (0.7); 7.9663 (0.7); 7.9582 (0.6); 7.2594 (0.7); 7.2464 (0.8); 7.2367 (0.8); 7.2318 (0.8); 7.2237 (0.8); 7.2187 (0.8); 7.2092 (0.8); 7.1961 (0.8); 7.1771 (1.0); 7.1603 (1.0); 6.7634 (0.8); 6.7549 (0.6); 6.7524 (0.6); 6.7498 (0.5); 6.7433 (0.9); 6.7351 (0.5); 6.7213 (0.6); 4.2621 (0.6); 4.2528 (0.6); 4.2440 (0.6); 3.6861 (0.7); 3.6563 (1.8); 3.6397 (2.1); 3.6306 (2.4); 3.6141 (2.4); 3.5499 (2.8); 3.1802 (1.3); 3.1714 (1.3); 3.1547 (1.2); 3.1457 (1.1); 3.1015 (1.0); 3.0895 (1.1); 3.0833 (1.0); 3.0713 (1.1); 3.0127 (1.7); 2.9980 (1.9); 2.9940 (2.0); 2.9796 (1.6); 2.7044 (1.0); 2.6844 (1.0); 2.6747 (0.6); 2.6700 (0.8); 2.6627 (1.3); 2.6427 (1.1); 2.5235 (2.2); 2.5188 (3.2); 2.5102 (40.0); 2.5055 (86.6); 2.5009 (120.3); 2.4963 (83.6); 2.4917 (36.8); 2.4557 (0.7); 2.4510 (0.8); 2.4464 (0.6); 2.3324 (0.5); 2.3277 (0.8); 2.3231 (0.5); 2.1517 (1.1); 2.1407 (1.1); 2.1096 (1.0); 2.0988 (1.0); 1.9082 (16.0); 1.8669 (0.7); 1.8502 (0.9); 1.8332 (0.7); 1.2015 (2.0); 1.1833 (4.3); 1.1650 (2.0); 0.8473 (8.3); 0.8345 (9.0); 0.8307 (8.9); 0.8179 (8.1); -0.0002 (7.4) I.4-93: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.1641 (9.2); 8.1603 (9.7); 8.1432 (10.3); 8.1394 (9.9); 7.9649 (13.6); 7.4631 (6.6); 7.4466 (6.7); 7.4106 (10.7); 7.4069 (11.1); 7.3905 (11.8); 7.3869 (11.9); 7.2651 (4.7); 7.2614 (4.6); 7.2465 (6.2); 7.2436 (8.0); 7.2410 (5.4); 7.2259 (5.2); 7.2222 (4.8); 6.9818 (7.6); 6.9779 (8.1); 6.9634 (8.3); 6.9619 (8.3); 6.9595 (8.2); 6.9579 (8.5); 6.9434 (6.6); 6.9395 (6.4); 5.7536 (16.0); 4.5492 (1.1); 4.5262 (2.8); 4.5058 (5.3); 4.4858 (3.0); 4.4822 (2.9); 4.4618 (1.2); 4.2883 (0.7); 4.2788 (1.4); 4.2695 (2.2); 4.2618 (3.1); 4.2528 (3.7); 4.2437 (3.2); 4.2362 (2.3); 4.2269 (1.4); 4.2169 (0.8); 4.0562 (0.6); 4.0384 (2.0); 4.0206 (2.0); 4.0028 (0.6); 3.7414 (6.8); 3.7250 (7.2); 3.7160 (8.3); 3.6997 (6.9); 3.3682 (1.9); 3.3490 (0.7); 3.3185 (408.9); 3.2914 (1.4); 3.2802 (7.0); 3.2713 (7.1); 3.2547 (6.2); 3.2461 (6.1); 3.2360 (0.9); 3.2189 (0.6); 2.6957 (7.3); 2.6758 (8.6); 2.6707 (1.6); 2.6658 (1.0); 2.6538 (9.1); 2.6340 (8.0); 2.5512 (1.2); 2.5240 (3.1); 2.5193 (4.7); 2.5106 (67.1); 2.5060 (147.5); 2.5014 (208.0); 2.4968 (145.4); 2.4922 (64.7); 2.4689 (1.1); 2.4561 (1.2); 2.4515 (1.5); 2.3329 (0.9); 2.3282 (1.3); 2.3235 (0.9); 2.2290 (0.9); 2.2166 (1.1); 2.2036 (2.7); 2.1907 (3.1); 2.1762 (4.8); 2.1716 (3.3); 2.1633 (4.7); 2.1518 (4.6); 2.1433 (9.5); 2.1389 (5.2); 2.1330 (8.3); 2.1144 (1.5); 2.1015 (6.4); 2.0910 (6.4); 2.0496 (0.6); 2.0375 (1.6); 2.0243 (2.8); 2.0197 (3.9); 2.0066 (5.0); 2.0039 (4.6); 1.9989 (4.6); 1.9943 (4.6); 1.9882 (13.1); 1.9789 (3.1); 1.9745 (3.6); 1.9672 (1.8); 1.9568 (1.5); 1.9447 (0.5); 1.9088 (6.3); 1.6701 (1.9); 1.6629 (1.5); 1.6538 (5.6); 1.6451 (4.2); 1.6406 (5.4); 1.6295 (10.2); 1.6162 (5.8); 1.6050 (4.7); 1.5902 (1.7); 1.1925 (2.8); 1.1748 (5.6); 1.1570 (2.7); -0.0002 (10.5) I.4-94: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.1470 (6.1); 8.1431 (6.0); 8.1261 (6.5); 8.1223 (5.9); 7.9495 (7.8); 7.4468 (4.1); 7.4303 (4.0); 7.4074 (6.8); 7.4039 (7.0); 7.3874 (7.3); 7.3838 (7.1); 7.2578 (3.1); 7.2542 (2.9); 7.2391 (4.2); 7.2363 (4.8); 7.2187 (3.4); 7.2150 (2.8); 6.9775 (4.9); 6.9736 (5.2); 6.9591 (5.4); 6.9575 (5.2); 6.9551 (5.2); 6.9536 (5.0); 6.9391 (4.3); 6.9352 (4.0); 4.2254 (1.0); 4.2159 (1.5); 4.2087 (2.1); 4.1996 (2.4); 4.1901 (2.1); 4.1829 (1.5); 4.1738 (0.9); 4.1630 (0.5); 4.0559 (0.9); 4.0382 (2.7); 4.0204 (2.7); 4.0027 (1.0); 3.5827 (5.4); 3.5663 (6.0); 3.5576 (6.7); 3.5412 (5.6); 3.3648 (2.5); 3.3152 (512.3); 3.2659 (5.7); 3.2156 (0.6); 3.0683 (4.4); 3.0593 (4.4); 3.0433 (4.2); 3.0345 (4.1); 2.6909 (1.2); 2.6801 (5.5); 2.6749 (3.5); 2.6700 (3.3); 2.6614 (8.1); 2.6506 (2.2); 2.6457 (2.1); 2.6397 (4.2); 2.6198 (3.6); 2.5465 (2.3); 2.5235 (6.8); 2.5188 (9.6); 2.5101 (131.8); 2.5055 (288.8); 2.5009 (406.7); 2.4963 (284.0); 2.4916 (126.0); 2.4558 (3.8); 2.4512 (5.2); 2.4466 (4.2); 2.4004 (0.9); 2.3324 (1.9); 2.3276 (2.5); 2.3231 (1.9); 2.3183 (1.0); 2.1439 (0.7); 2.1280 (3.7); 2.1171 (3.8); 2.0860 (3.3); 2.0753 (3.2); 1.9880 (13.1); 1.8872 (1.4); 1.1924 (3.8); 1.1745 (7.9); 1.1567 (3.7); 0.8290 (0.7); 0.7098 (0.6); 0.6965 (1.8); 0.6939 (1.8); 0.6834 (1.4); 0.6781 (3.6); 0.6756 (3.5); 0.6666 (16.0); 0.6617 (5.8); 0.6561 (3.7); 0.6520 (8.8); 0.6480 (11.5); 0.6429 (5.3); 0.6412 (5.7); 0.6375 (3.6); 0.6333 (6.3); 0.6198 (1.9); 0.6144 (1.4); 0.6096 (1.9); 0.5971 (1.1); 0.0081 (2.0); -0.0002 (72.5); -0.0086 (2.2) I.4-95: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.1478 (1.9); 8.1439 (1.9); 8.1269 (2.1); 8.1231 (2.0); 7.9804 (2.6); 7.4952 (1.0); 7.4793 (1.0); 7.4085 (2.2); 7.4049 (2.2); 7.3884 (2.4); 7.3848 (2.3); 7.2608 (1.0); 7.2571 (0.9); 7.2421 (1.3); 7.2392 (1.6); 7.2365 (1.0); 7.2216 (1.0); 7.2179 (1.0); 6.9795 (1.6); 6.9755 (1.7); 6.9610 (1.7); 6.9595 (1.6); 6.9571 (1.6); 6.9555 (1.7); 6.9411 (1.4); 6.9371 (1.3); 4.2551 (0.6); 4.2461 (0.6); 4.2372 (0.6); 3.6607 (0.7); 3.6574 (1.8); 3.6411 (1.9); 3.6318 (2.2); 3.6155 (2.0); 3.5289 (1.4); 3.1897 (1.4); 3.1809 (1.4); 3.1641 (1.3); 3.1554 (1.3); 3.0976 (0.8); 3.0855 (0.8); 3.0794 (0.8); 3.0673 (0.8); 3.0167 (2.1); 3.0098 (2.1); 2.9980 (2.2); 2.9912 (2.1); 2.7123 (1.1); 2.6924 (1.2); 2.6706 (1.6); 2.6506 (1.2); 2.5242 (0.7); 2.5195 (1.0); 2.5109 (15.1); 2.5062 (33.3); 2.5016 (47.0); 2.4970 (32.7); 2.4924 (14.3); 2.4518 (0.6); 2.1515 (1.2); 2.1409 (1.2); 2.1097 (1.1); 2.0992 (1.1); 1.9882 (0.5); 1.9089 (16.0); 1.8710 (0.8); 1.8542 (1.0); 1.8374 (0.8); 1.2035 (1.5); 1.1853 (3.2); 1.1670 (1.5); 0.8504 (9.5); 0.8344 (14.2); 0.8185 (9.2); -0.0002 (10.6) I.4-96: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.1578 (3.1); 8.1540 (3.1); 8.1370 (3.4); 8.1331 (3.2); 7.9652 (4.2); 7.4415 (2.1); 7.4250 (2.1); 7.4095 (3.6); 7.4060 (3.7); 7.3895 (3.9); 7.3858 (3.8); 7.2622 (1.5); 7.2585 (1.5); 7.2436 (2.0); 7.2407 (2.6); 7.2380 (1.7); 7.2230 (1.7); 7.2193 (1.5); 6.9800 (2.6); 6.9760 (2.8); 6.9615 (2.9); 6.9600 (2.7); 6.9576 (2.7); 6.9560 (2.8); 6.9416 (2.3); 6.9376 (2.2); 4.2589 (0.8); 4.2512 (1.0); 4.2423 (1.2); 4.2332 (1.0); 4.2258 (0.8); 4.2119 (0.8); 4.1949 (1.8); 4.1779 (2.6); 4.1609 (1.9); 4.1440 (0.8); 3.6055 (2.4); 3.5893 (2.6); 3.5801 (2.9); 3.5639 (2.5); 3.3721 (0.7); 3.3146 (157.1); 3.2646 (1.2); 3.1200 (2.3); 3.1113 (2.3); 3.0946 (2.1); 3.0859 (2.0); 2.6771 (2.7); 2.6700 (0.7); 2.6654 (0.5); 2.6573 (2.9); 2.6355 (3.3); 2.6157 (2.9); 2.5235 (1.7); 2.5188 (2.4); 2.5101 (32.6); 2.5055 (71.6); 2.5009 (100.6); 2.4963 (70.3); 2.4917 (31.1); 2.4557 (0.8); 2.4509 (0.9); 2.4464 (0.7); 2.3277 (0.6); 2.1269 (2.4); 2.1164 (2.4); 2.0853 (2.1); 2.0747 (2.1); 2.0405 (1.0); 1.9880 (0.6); 1.0904 (15.5); 1.0734 (15.8); 1.0669 (16.0); 1.0499 (15.3); 1.0265 (0.5); 0.8728 (0.9); 0.0080 (1.0); -0.0002 (41.1); -0.0086 (1.2) I.4-97: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.1907 (4.0); 8.1849 (3.8); 8.1064 (2.2); 8.1021 (2.3); 8.0856 (4.5); 8.0814 (4.3); 8.0648 (2.4); 8.0606 (2.2); 7.1981 (2.6); 7.1945 (2.6); 7.1777 (3.0); 7.1740 (3.1); 7.1687 (2.5); 7.1651 (2.7); 7.1483 (2.9); 7.1447 (3.1); 7.0957 (1.9); 7.0765 (3.9); 7.0567 (2.4); 7.0145 (3.5); 6.9974 (3.5); 6.9598 (2.0); 6.9555 (2.0); 6.9470 (2.1); 6.9426 (2.6); 6.9368 (2.0); 6.9283 (2.2); 6.9240 (2.2); 6.9224 (2.0); 6.9165 (1.2); 6.9080 (1.2); 6.9037 (1.1); 5.7539 (1.9); 4.2264 (0.8); 4.2206 (1.1); 4.2170 (1.2); 4.2095 (1.8); 4.2003 (2.0); 4.1911 (1.8); 4.1838 (1.2); 4.1799 (1.1); 4.1738 (0.8); 3.5764 (4.9); 3.5598 (5.2); 3.5514 (5.9); 3.5349 (5.0); 3.3642 (1.8); 3.3429 (0.7); 3.3144 (321.0); 3.2841 (0.7); 3.2811 (0.6); 3.2640 (3.0); 3.0599 (4.0); 3.0505 (4.0); 3.0349 (3.8); 3.0257 (3.7); 2.6792 (1.4); 2.6746 (1.3); 2.6697 (2.4); 2.6647 (5.9); 2.6503 (3.1); 2.6457 (4.1); 2.6391 (1.9); 2.6339 (1.7); 2.6233 (4.7); 2.6037 (3.4); 2.5507 (1.7); 2.5466 (1.6); 2.5235 (3.9); 2.5188 (5.6); 2.5101 (74.6); 2.5055 (162.6); 2.5009 (228.6); 2.4962 (159.1); 2.4916 (70.1); 2.4553 (2.1); 2.4507 (2.9); 2.4462 (2.3); 2.3323 (1.0); 2.3277 (1.5); 2.3231 (1.0); 2.1268 (3.4); 2.1155 (3.4); 2.0849 (2.9); 2.0736 (3.1); 1.9880 (0.8); 1.2359 (1.3); 0.7053 (0.5); 0.6917 (1.5); 0.6874 (1.6); 0.6754 (3.7); 0.6681 (3.9); 0.6636 (16.0); 0.6594 (7.1); 0.6505 (6.0); 0.6471 (12.7); 0.6381 (3.1); 0.6363 (3.2); 0.6325 (4.4); 0.6298 (4.3); 0.6264 (4.6); 0.6177 (1.7); 0.6111 (1.4); 0.6028 (1.6); 0.5915 (0.9); 0.0080 (3.2); -0.0002 (110.7); -0.0085 (3.3); -0.0503 (0.9) I.4-98: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.2191 (2.2); 8.2131 (2.2); 8.1217 (1.3); 8.1175 (1.4); 8.1010 (2.6); 8.0968 (2.6); 8.0802 (1.4); 8.0760 (1.3); 7.2006 (1.5); 7.1970 (1.5); 7.1802 (1.7); 7.1766 (1.8); 7.1713 (1.5); 7.1677 (1.6); 7.1509 (1.7); 7.1473 (1.8); 7.0999 (1.1); 7.0799 (2.1); 7.0609 (1.3); 7.0233 (2.0); 7.0064 (2.0); 6.9614 (1.2); 6.9571 (1.3); 6.9486 (1.2); 6.9442 (1.5); 6.9428 (1.4); 6.9411 (1.2); 6.9384 (1.2); 6.9368 (1.2); 6.9299 (1.2); 6.9283 (1.1); 6.9256 (1.2); 6.9239 (1.2); 6.9181 (0.7); 6.9095 (0.7); 6.9053 (0.7); 4.2570 (0.7); 4.2491 (1.0); 4.2404 (1.2); 4.2317 (1.0); 4.2238 (0.8); 4.2076 (0.8); 4.1907 (1.9); 4.1737 (2.6); 4.1567 (1.9); 4.1398 (0.7); 3.6006 (2.4); 3.5842 (2.5); 3.5752 (2.9); 3.5588 (2.5); 3.3648 (0.7); 3.3156 (151.5); 3.2656 (1.8); 3.1097 (2.2); 3.1006 (2.2); 3.0843 (2.0); 3.0753 (2.0); 2.6701 (0.6); 2.6654 (0.5); 2.6605 (2.8); 2.6408 (2.9); 2.6189 (3.3); 2.5992 (2.9); 2.5508 (0.6); 2.5236 (1.3); 2.5189 (2.0); 2.5102 (29.8); 2.5056 (66.2); 2.5010 (93.9); 2.4964 (65.2); 2.4917 (28.7); 2.4602 (0.5); 2.4554 (0.9); 2.4508 (1.2); 2.4462 (0.9); 2.3278 (0.6); 2.1253 (2.4); 2.1144 (2.4); 2.0837 (2.1); 2.0728 (3.1); 1.0866 (15.2); 1.0696 (15.9); 1.0651 (16.0); 1.0481 (15.0); 0.0080 (0.5); -0.0002 (20.3); -0.0086 (0.5) I.4-99: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.2084 (11.7); 8.1129 (5.4); 8.0922 (10.7); 8.0716 (6.1); 7.1959 (6.0); 7.1753 (7.3); 7.1665 (6.8); 7.1461 (8.0); 7.0969 (5.8); 7.0768 (11.1); 7.0574 (7.0); 7.0288 (10.0); 7.0125 (10.5); 6.9565 (4.2); 6.9419 (6.8); 6.9247 (6.0); 6.9087 (3.2); 5.7526 (1.5); 4.3694 (5.0); 4.3502 (7.2); 4.3303 (4.8); 4.2550 (3.8); 4.2463 (4.9); 4.2382 (5.8); 4.2290 (5.2); 3.6346 (8.3); 3.6181 (8.9); 3.6092 (10.3); 3.5930 (8.9); 3.4094 (1.5); 3.3604 (2.4); 3.3076 (733.5); 3.2745 (10.7); 3.2585 (12.7); 3.2479 (2.6); 3.1296 (9.2); 3.1205 (10.3); 3.1040 (10.4); 3.0955 (11.0); 2.6680 (16.5); 2.6479 (9.5); 2.6259 (11.0); 2.6062 (12.0); 2.5625 (3.8); 2.5571 (4.0); 2.5225 (16.2); 2.5046 (1164.6); 2.5001 (1638.1); 2.4956 (1234.1); 2.4913 (632.8); 2.4593 (36.5); 2.4546 (35.2); 2.4500 (32.8); 2.4454 (23.4); 2.4407 (14.8); 2.3269 (9.9); 2.1300 (9.6); 2.1191 (9.8); 2.0879 (8.5); 2.0775 (8.4); 1.7158 (6.4); 1.6871 (7.1); 1.6421 (10.5); 1.5291 (12.6); 1.5121 (16.0); 1.4890 (8.8); 1.4701 (5.4); 1.1941 (4.6); 1.1760 (9.2); 1.1584 (5.2); 0.0080 (3.6); -0.0002 (115.3); -0.0084 (6.1); -0.0504 (2.1) I.4-100: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.4615 (1.4); 8.1425 (2.6); 8.1394 (2.5); 8.1359 (1.9); 8.0429 (1.2); 8.0370 (1.1); 8.0341 (1.2); 8.0276 (1.8); 8.0231 (1.1); 8.0192 (1.4); 8.0134 (1.6); 8.0069 (0.9); 7.9985 (0.8); 7.9904 (0.8); 7.9865 (0.8); 7.9784 (0.7); 7.9702 (0.8); 7.9622 (0.7); 7.6201 (0.5); 7.6096 (5.5); 7.6072 (4.8); 7.6010 (2.4); 7.5976 (2.4); 7.5945 (2.6); 7.5930 (2.5); 7.3042 (1.5); 7.2877 (1.5); 7.2617 (0.8); 7.2488 (0.9); 7.2391 (0.9); 7.2343 (0.8); 7.2259 (0.8); 7.2213 (0.8); 7.2117 (0.9); 7.1986 (0.9); 6.7825 (0.6); 6.7735 (0.8); 6.7628 (0.7); 6.7534 (1.0); 6.7452 (0.6); 6.7312 (0.7); 4.4320 (0.6); 4.4226 (0.7); 4.4135 (0.7); 4.2015 (1.3); 4.1850 (1.3); 4.1759 (1.6); 4.1596 (1.2); 3.7580 (1.2); 3.7489 (1.2); 3.7325 (1.1); 3.7234 (1.0); 3.3138 (57.1); 3.1130 (0.5); 3.1011 (0.5); 3.0949 (0.5); 3.0829 (0.5); 3.0247 (1.3); 3.0049 (1.4); 2.9819 (1.6); 2.9622 (1.4); 2.6742 (0.9); 2.6696 (1.2); 2.6649 (0.9); 2.5232 (2.1); 2.5185 (3.4); 2.5098 (64.7); 2.5052 (144.2); 2.5005 (203.5); 2.4959 (142.6); 2.4913 (63.4); 2.4721 (2.3); 2.4550 (1.0); 2.4505 (1.3); 2.4460 (1.0); 2.4409 (1.5); 2.4296 (1.2); 2.3319 (1.0); 2.3274 (1.3); 2.3228 (0.9); 1.9879 (2.1); 1.9081 (16.0); 1.1957 (1.1); 1.1924 (0.7); 1.1775 (2.3); 1.1746 (1.6); 1.1592 (1.1); 1.1568 (0.8); 0.0080 (1.7); -0.0002 (72.3); -0.0085 (2.2) I.4-101: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.5243 (2.0); 8.0219 (1.2); 8.0138 (1.2); 8.0058 (1.1); 7.9975 (1.2); 7.9937 (1.2); 7.9855 (1.0); 7.9774 (1.1); 7.9692 (1.1); 7.4948 (1.1); 7.4909 (1.2); 7.4753 (2.3); 7.4713 (2.4); 7.4555 (1.4); 7.4515 (1.4); 7.3648 (0.5); 7.3606 (0.7); 7.3575 (1.2); 7.3533 (1.2); 7.3393 (3.4); 7.3328 (4.2); 7.3266 (2.1); 7.3222 (2.1); 7.3172 (2.6); 7.3119 (2.5); 7.3075 (2.4); 7.2909 (1.0); 7.2865 (0.7); 7.2728 (2.1); 7.2689 (2.1); 7.2559 (3.1); 7.2536 (2.0); 7.2507 (1.8); 7.2468 (2.2); 7.2417 (1.4); 7.2363 (2.0); 7.2336 (1.5); 7.2310 (1.5); 7.2289 (1.4); 7.2191 (1.2); 7.2060 (1.2); 6.7822 (0.7); 6.7733 (1.2); 6.7647 (0.8); 6.7623 (1.0); 6.7597 (0.8); 6.7531 (1.4); 6.7450 (0.8); 6.7399 (0.8); 6.7310 (1.0); 6.7224 (0.5); 4.4598 (0.6); 4.4529 (0.9); 4.4433 (1.0); 4.4347 (0.9); 4.4269 (0.6); 4.1121 (1.6); 4.0961 (1.6); 4.0874 (1.8); 4.0720 (1.6); 4.0383 (0.8); 4.0204 (0.7); 3.6057 (1.8); 3.5965 (1.8); 3.5812 (1.8); 3.5717 (1.8); 3.4742 (3.0); 2.9263 (2.0); 2.9068 (2.2); 2.8838 (2.5); 2.8643 (2.2); 2.6744 (0.7); 2.6698 (1.0); 2.6652 (0.8); 2.5232 (2.2); 2.5186 (3.4); 2.5099 (57.4); 2.5053 (126.8); 2.5007 (178.0); 2.4960 (125.1); 2.4914 (55.9); 2.4603 (1.1); 2.4556 (1.4); 2.4511 (1.6); 2.4464 (1.1); 2.3740 (2.0); 2.3628 (2.0); 2.3318 (2.4); 2.3275 (1.4); 2.3205 (2.0); 1.9879 (3.3); 1.9083 (16.0); 1.1974 (0.6); 1.1924 (1.0); 1.1792 (1.4); 1.1747 (2.1); 1.1609 (0.6); 1.1568 (1.0); 0.0080 (1.4); -0.0002 (53.1); -0.0085 (1.6) I.4-102: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.8201 (1.9); 7.7998 (2.0); 7.6822 (3.2); 7.5008 (0.9); 7.4968 (1.0); 7.4813 (1.9); 7.4772 (2.0); 7.4618 (1.1); 7.4575 (1.2); 7.3579 (0.6); 7.3551 (1.0); 7.3508 (1.1); 7.3448 (0.7); 7.3384 (3.1); 7.3348 (2.0); 7.3329 (2.1); 7.3242 (1.4); 7.3198 (1.3); 7.3112 (1.5); 7.3069 (1.9); 7.2905 (0.7); 7.2720 (1.7); 7.2676 (1.0); 7.2658 (1.0); 7.2551 (1.8); 7.2525 (1.5); 7.2498 (1.3); 7.2456 (0.8); 7.2357 (1.4); 7.2301 (0.9); 7.1734 (1.7); 7.1571 (1.7); 7.1330 (1.6); 7.1128 (2.0); 7.0904 (1.6); 7.0712 (1.0); 6.9034 (1.3); 6.9003 (1.3); 6.8849 (2.2); 6.8818 (2.1); 6.8664 (1.0); 6.8634 (0.9); 5.7544 (1.8); 4.4375 (0.7); 4.4284 (0.8); 4.4199 (0.8); 4.4126 (0.5); 4.0998 (1.3); 4.0835 (1.3); 4.0762 (1.5); 4.0600 (1.3); 3.6126 (1.4); 3.6031 (1.4); 3.5881 (1.3); 3.5786 (1.3); 3.3220 (4.6); 3.1236 (0.8); 3.1116 (0.8); 3.1054 (2.4); 3.0934 (2.5); 3.0871 (2.5); 3.0752 (2.5); 3.0690 (0.8); 3.0570 (0.8); 2.9144 (1.7); 2.8947 (1.9); 2.8721 (2.2); 2.8523 (1.9); 2.6698 (0.6); 2.5233 (1.4); 2.5186 (2.0); 2.5099 (32.6); 2.5053 (72.1); 2.5006 (101.1); 2.4960 (70.5); 2.4914 (31.2); 2.4552 (0.8); 2.4506 (1.0); 2.4460 (0.7); 2.3845 (1.6); 2.3731 (1.6); 2.3420 (1.5); 2.3309 (1.7); 2.3229 (0.6); 2.1822 (16.0); 1.9083 (5.5); 1.1987 (5.4); 1.1805 (11.4); 1.1622 (5.2); 0.0080 (1.5); 0.0048 (0.6); 0.0039 (0.8); -0.0002 (50.9); -0.0050 (0.7); -0.0059 (0.6); -0.0085 (1.4) I.4-103: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 7.8273 (1.9); 7.8249 (1.9); 7.8069 (2.1); 7.7411 (0.6); 7.7331 (6.3); 7.7276 (1.8); 7.7159 (2.0); 7.7104 (7.5); 7.7024 (0.7); 7.6111 (3.4); 7.4556 (0.8); 7.4476 (7.7); 7.4420 (2.0); 7.4303 (1.9); 7.4249 (6.6); 7.4168 (0.6); 7.1415 (1.8); 7.1247 (3.2); 7.1049 (2.6); 7.0880 (1.7); 7.0685 (1.0); 6.8978 (1.3); 6.8949 (1.3); 6.8793 (2.1); 6.8763 (2.1); 6.8608 (1.0); 6.8578 (0.9); 4.4030 (0.5); 4.3956 (0.8); 4.3865 (0.9); 4.3779 (0.8); 4.3699 (0.6); 4.1608 (1.5); 4.1447 (1.6); 4.1355 (1.9); 4.1194 (1.5); 3.6857 (1.4); 3.6772 (1.4); 3.6604 (1.3); 3.6521 (1.2); 3.3170 (62.7); 3.2672 (0.5); 2.9877 (1.5); 2.9682 (1.7); 2.9452 (1.9); 2.9257 (1.7); 2.5233 (0.8); 2.5186 (1.2); 2.5099 (22.9); 2.5054 (50.2); 2.5007 (70.2); 2.4961 (49.5); 2.4916 (22.4); 2.4554 (0.6); 2.4508 (0.8); 2.4460 (1.9); 2.4355 (1.5); 2.4032 (1.3); 2.3930 (1.3); 2.1594 (16.0); 1.1956 (0.7); 1.1775 (1.5); 1.1591 (0.7); 0.0080 (0.7); -0.0002 (26.6); -0.0085 (0.8) I.4-104: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.0595 (3.6); 8.0537 (3.6); 7.7377 (3.5); 7.7185 (3.4); 7.7126 (1.1); 7.7062 (3.6); 7.7007 (1.8); 7.6952 (3.8); 7.6888 (1.1); 7.6829 (3.5); 7.3152 (1.8); 7.2990 (1.8); 7.2463 (4.0); 7.2404 (1.0); 7.2289 (1.2); 7.2246 (5.1); 7.2190 (1.1); 7.2074 (1.0); 7.2016 (3.5); 7.1449 (2.3); 7.1434 (2.2); 7.1246 (2.7); 7.1231 (2.7); 6.9170 (2.4); 6.9114 (2.3); 6.8969 (2.0); 6.8913 (2.0); 4.4009 (0.5); 4.3930 (0.7); 4.3843 (0.8); 4.3756 (0.8); 4.3682 (0.6); 4.1717 (1.7); 4.1557 (1.7); 4.1463 (2.1); 4.1304 (1.6); 3.6867 (1.4); 3.6783 (1.4); 3.6613 (1.3); 3.6530 (1.2); 3.3134 (195.8); 3.2634 (1.2); 2.9871 (1.6); 2.9677 (1.7); 2.9447 (2.0); 2.9253 (1.8); 2.6745 (0.6); 2.6698 (0.9); 2.6651 (0.6); 2.5233 (1.7); 2.5186 (2.6); 2.5099 (47.1); 2.5053 (104.7); 2.5007 (147.1); 2.4961 (102.6); 2.4915 (45.4); 2.4553 (1.0); 2.4508 (1.2); 2.4461 (0.9); 2.4278 (1.6); 2.4178 (1.6); 2.3855 (1.3); 2.3755 (1.3); 2.3321 (0.7); 2.3275 (0.9); 2.3228 (0.6); 2.1405 (16.0); 0.0080 (1.1); -0.0002 (39.8); -0.0085 (1.1) I.4-105: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.0479 (3.6); 8.0422 (3.5); 7.8026 (3.5); 7.5001 (0.9); 7.4966 (1.0); 7.4811 (1.9); 7.4770 (1.9); 7.4614 (1.1); 7.4572 (1.2); 7.3570 (1.0); 7.3528 (1.0); 7.3468 (0.8); 7.3402 (3.3); 7.3345 (3.6); 7.3262 (1.7); 7.3218 (1.8); 7.3183 (2.2); 7.3131 (1.9); 7.3086 (2.0); 7.2922 (0.7); 7.2738 (1.7); 7.2693 (0.9); 7.2568 (1.7); 7.2541 (1.4); 7.2375 (1.3); 7.2320 (0.8); 7.1552 (2.4); 7.1348 (2.7); 7.1334 (2.7); 6.9239 (2.3); 6.9182 (2.3); 6.9037 (2.0); 6.8981 (1.9); 4.4467 (0.5); 4.4398 (0.8); 4.4306 (0.8); 4.4216 (0.8); 4.4145 (0.6); 4.1148 (1.2); 4.0989 (1.3); 4.0903 (1.5); 4.0742 (1.2); 3.6149 (1.4); 3.6055 (1.4); 3.5902 (1.3); 3.5811 (1.2); 3.3201 (234.8); 3.2700 (1.1); 2.9326 (1.6); 2.9129 (1.8); 2.8901 (2.1); 2.8705 (1.8); 2.6747 (0.6); 2.6700 (0.8); 2.6654 (0.6); 2.5235 (1.8); 2.5188 (2.7); 2.5101 (42.9); 2.5055 (94.2); 2.5009 (131.9); 2.4963 (91.6); 2.4917 (40.1); 2.4557 (0.7); 2.4512 (0.8); 2.4467 (0.5); 2.3829 (1.6); 2.3719 (1.6); 2.3405 (1.4); 2.3292 (1.7); 2.3231 (0.7); 2.1625 (16.0); 2.0726 (1.6); 1.1772 (0.8); 0.0080 (1.0); -0.0002 (42.0); -0.0085 (1.2) I.4-106: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.4555 (1.5); 8.0082 (0.8); 7.9998 (0.8); 7.9916 (0.8); 7.9836 (0.9); 7.9797 (0.9); 7.9715 (0.8); 7.9636 (0.8); 7.9553 (0.8); 7.9054 (2.8); 7.8997 (1.1); 7.8883 (1.9); 7.8825 (7.8); 7.8780 (1.5); 7.8629 (1.5); 7.8585 (8.0); 7.8526 (1.6); 7.8412 (1.0); 7.8356 (2.8); 7.3073 (1.5); 7.2904 (1.6); 7.2592 (0.9); 7.2463 (0.9); 7.2365 (0.9); 7.2318 (0.9); 7.2235 (0.9); 7.2187 (0.9); 7.2091 (0.9); 7.1960 (0.9); 6.7815 (0.5); 6.7726 (0.8); 6.7617 (0.7); 6.7526 (1.1); 6.7445 (0.6); 6.7302 (0.7); 4.4234 (0.7); 4.4147 (0.7); 4.2087 (1.3); 4.1923 (1.3); 4.1830 (1.7); 4.1666 (1.2); 4.0381 (1.2); 4.0204 (1.2); 3.7565 (1.2); 3.7477 (1.2); 3.7309 (1.1); 3.7220 (1.0); 3.3336 (39.2); 3.0399 (1.3); 3.0204 (1.4); 2.9972 (1.6); 2.9776 (1.4); 2.6742 (0.9); 2.6697 (1.3); 2.6651 (0.9); 2.5231 (3.8); 2.5184 (5.9); 2.5098 (74.2); 2.5052 (160.2); 2.5006 (222.2); 2.4960 (154.5); 2.4914 (69.9); 2.4596 (1.8); 2.4501 (2.0); 2.3321 (1.1); 2.3274 (1.3); 2.3228 (1.0); 2.0726 (0.8); 1.9879 (5.6); 1.9080 (16.0); 1.1956 (0.6); 1.1924 (1.6); 1.1776 (1.5); 1.1746 (3.3); 1.1568 (1.6); 0.0080 (1.8); -0.0002 (59.8); -0.0085 (1.8) I.4-107: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 7.9138 (0.9); 7.7011 (0.9); 7.6888 (1.0); 7.6779 (1.0); 7.6656 (1.0); 7.2384 (1.2); 7.2165 (1.5); 7.1938 (1.0); 7.1151 (1.0); 7.0952 (1.3); 7.0748 (1.0); 7.0592 (0.5); 5.3093 (1.2); 4.1096 (0.6); 3.3770 (1.0); 3.3588 (1.1); 3.3405 (0.5); 3.3153 (78.0); 3.0986 (0.9); 3.0804 (2.8); 3.0621 (2.8); 3.0440 (1.0); 2.8783 (0.6); 2.5236 (0.6); 2.5188 (0.9); 2.5102 (13.2); 2.5056 (29.0); 2.5010 (40.8); 2.4964 (28.9); 2.4918 (13.1); 2.4759 (0.6); 1.2514 (0.9); 1.2333 (1.8); 1.2150 (1.1); 1.2084 (7.7); 1.1902 (16.0); 1.1720 (7.3) I.4-108: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.0482 (3.6); 8.0425 (3.5); 7.7415 (3.2); 7.1805 (1.3); 7.1643 (1.3); 7.1441 (2.4); 7.1426 (2.3); 7.1238 (2.7); 7.1223 (2.6); 6.9123 (2.4); 6.9067 (2.2); 6.8922 (1.9); 6.8865 (1.9); 4.3738 (0.8); 4.3548 (1.2); 4.3348 (0.7); 4.2503 (0.5); 4.2424 (0.7); 4.2338 (0.8); 4.2252 (0.7); 4.0560 (0.6); 4.0382 (1.7); 4.0204 (1.8); 4.0026 (0.6); 3.6382 (1.7); 3.6220 (1.8); 3.6129 (2.0); 3.5968 (1.8); 3.4792 (3.2); 3.1401 (1.6); 3.1314 (1.5); 3.1149 (1.4); 3.1060 (1.7); 2.6823 (1.7); 2.6701 (0.5); 2.6625 (2.0); 2.6406 (2.2); 2.6208 (1.9); 2.5236 (1.3); 2.5188 (1.9); 2.5102 (25.0); 2.5056 (54.3); 2.5010 (76.2); 2.4963 (52.7); 2.4917 (23.0); 2.4510 (0.5); 2.1450 (16.0); 2.1303 (1.8); 2.0991 (1.5); 2.0886 (1.5); 1.9880 (8.2); 1.9084 (6.3); 1.7189 (0.9); 1.7106 (0.9); 1.7066 (0.9); 1.7015 (0.8); 1.6907 (1.0); 1.6719 (0.8); 1.6506 (1.2); 1.6427 (1.5); 1.6287 (1.0); 1.5473 (0.9); 1.5406 (1.2); 1.5298 (1.8); 1.5194 (2.2); 1.5146 (2.4); 1.4912 (1.2); 1.4724 (0.7); 1.1993 (0.6); 1.1924 (2.5); 1.1811 (1.3); 1.1746 (5.0); 1.1629 (0.6); 1.1569 (2.4); 0.0081 (1.6); - 0.0002 (57.4); -0.0086 (1.6) I.4-109: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.5431 (4.5); 7.4852 (3.1); 7.4629 (3.7); 7.4183 (6.8); 7.3961 (9.0); 7.3355 (3.5); 7.3130 (2.7); 7.2706 (9.0); 7.2488 (6.4); 6.6210 (2.7); 6.6023 (2.6); 3.6159 (2.4); 3.3066 (157.2); 3.1717 (2.4); 2.9945 (4.1); 2.9821 (4.2); 2.6694 (4.3); 2.6379 (2.4); 2.6169 (2.5); 2.5962 (2.7); 2.5093 (240.8); 2.5049 (488.2); 2.5004 (646.4); 2.4960 (461.7); 2.4918 (227.0); 2.3278 (3.5); 2.2025 (2.4); 1.1762 (2.5); 0.8441 (13.1); 0.8304 (16.0); 0.8145 (12.6); 0.0008 (104.7); -0.0002 (141.1) I.4-110: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.8350 (0.5); 8.5445 (6.6); 7.4856 (1.0); 7.4632 (1.4); 7.4317 (1.0); 7.4239 (11.7); 7.4185 (3.7); 7.4069 (4.1); 7.4015 (16.0); 7.3938 (1.7); 7.3353 (1.4); 7.3131 (1.0); 7.2803 (1.6); 7.2725 (15.7); 7.2672 (4.2); 7.2555 (3.5); 7.2503 (11.7); 7.2424 (1.1); 6.6189 (3.4); 6.6020 (3.5); 5.7531 (0.5); 4.5364 (0.6); 4.5135 (1.5); 4.4929 (2.7); 4.4730 (1.6); 4.4493 (0.6); 4.2754 (0.7); 4.2704 (0.9); 4.2651 (0.9); 4.2581 (1.6); 4.2487 (1.5); 4.2402 (1.6); 4.2328 (0.9); 4.2279 (1.0); 4.2224 (0.7); 3.7248 (3.4); 3.7077 (3.5); 3.6997 (4.0); 3.6827 (3.4); 3.3085 (65.1); 3.2638 (3.5); 3.2537 (3.4); 3.2388 (3.0); 3.2287 (3.0); 2.6742 (0.8); 2.6696 (1.1); 2.6649 (0.8); 2.6426 (3.5); 2.6223 (3.8); 2.6007 (4.5); 2.5804 (4.1); 2.5230 (3.3); 2.5183 (4.8); 2.5096 (62.4); 2.5051 (133.0); 2.5005 (183.5); 2.4959 (127.9); 2.4914 (57.6); 2.3319 (0.8); 2.3273 (1.1); 2.3227 (0.8); 2.2116 (0.7); 2.1936 (4.6); 2.1865 (3.0); 2.1817 (4.6); 2.1619 (4.3); 2.1518 (4.2); 2.1393 (5.4); 2.1128 (1.0); 2.0195 (1.0); 2.0076 (2.1); 1.9945 (2.6); 1.9885 (2.9); 1.9825 (2.2); 1.9747 (2.6); 1.9694 (1.7); 1.9629 (1.9); 1.9492 (0.8); 1.6619 (1.0); 1.6553 (0.8); 1.6460 (2.9); 1.6368 (2.2); 1.6327 (2.7); 1.6216 (5.2); 1.6082 (2.8); 1.5969 (2.3); 1.5821 (0.8); 0.0080 (3.4); -0.0002 (100.2); -0.0086 (2.7) I.4-111: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.0566 (3.2); 8.0509 (3.2); 7.7183 (3.0); 7.1515 (1.6); 7.1461 (2.6); 7.1445 (2.4); 7.1349 (1.6); 7.1258 (2.6); 7.1242 (2.5); 6.9153 (2.1); 6.9096 (2.1); 6.8953 (1.8); 6.8895 (1.8); 5.7535 (3.4); 4.5290 (0.6); 4.5055 (1.2); 4.4854 (0.6); 4.2643 (0.5); 4.2567 (0.7); 4.2477 (0.8); 4.2387 (0.7); 3.7415 (1.5); 3.7251 (1.6); 3.7162 (1.8); 3.6998 (1.5); 3.3155 (73.7); 3.2787 (1.5); 3.2698 (1.5); 3.2534 (1.4); 3.2446 (1.3); 2.6924 (1.6); 2.6725 (1.9); 2.6505 (2.0); 2.6306 (1.8); 2.5236 (1.0); 2.5189 (1.3); 2.5102 (15.9); 2.5056 (34.3); 2.5010 (47.8); 2.4963 (33.1); 2.4917 (14.4); 2.2024 (0.7); 2.1997 (0.7); 2.1928 (0.8); 2.1750 (1.4); 2.1684 (1.2); 2.1654 (1.1); 2.1525 (2.8); 2.1434 (16.0); 2.1109 (1.4); 2.1001 (1.4); 2.0178 (0.9); 2.0074 (1.0); 2.0024 (1.2); 1.9921 (1.0); 1.9880 (2.3); 1.9830 (1.0); 1.9745 (0.8); 1.9084 (1.1); 1.6543 (1.2); 1.6453 (1.0); 1.6411 (1.2); 1.6299 (2.2); 1.6166 (1.2); 1.6053 (1.0); 1.1747 (0.8); 0.0081 (0.6); -0.0002 (21.8); -0.0086 (0.6) I.4-112: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.0339 (3.4); 8.0282 (3.2); 7.7662 (2.7); 7.2047 (1.4); 7.1880 (1.3); 7.1409 (2.2); 7.1394 (2.1); 7.1206 (2.6); 7.1191 (2.5); 6.9094 (2.2); 6.9039 (2.1); 6.8894 (1.8); 6.8837 (1.8); 5.7542 (5.0); 4.2098 (0.5); 4.2024 (0.7); 4.1933 (0.8); 4.1842 (0.7); 3.5755 (1.9); 3.5590 (2.0); 3.5505 (2.3); 3.5340 (1.9); 3.3137 (41.8); 3.0715 (1.6); 3.0624 (1.6); 3.0465 (1.5); 3.0374 (1.4); 2.6751 (2.0); 2.6698 (1.1); 2.6654 (1.8); 2.6550 (1.9); 2.6490 (0.7); 2.6344 (1.6); 2.6131 (1.3); 2.5234 (1.3); 2.5187 (1.8); 2.5100 (31.4); 2.5054 (69.6); 2.5007 (97.8); 2.4961 (68.3); 2.4915 (30.1); 2.4554 (0.8); 2.4507 (0.9); 2.4461 (0.6); 2.3276 (0.6); 2.1439 (16.0); 2.1299 (1.5); 2.0989 (1.3); 2.0881 (1.3); 1.8026 (0.5); 1.2339 (0.5); 0.6924 (0.8); 0.6740 (1.5); 0.6726 (1.3); 0.6643 (5.0); 0.6579 (2.3); 0.6524 (2.6); 0.6498 (2.2); 0.6461 (3.9); 0.6447 (3.5); 0.6397 (2.9); 0.6340 (2.0); 0.6192 (0.5); 0.6094 (0.6); 0.0080 (1.4); 0.0040 (0.5); -0.0002 (51.5); -0.0050 (0.8); -0.0058 (0.6); -0.0066 (0.6); -0.0085 (1.5) I.4-113: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.0480 (3.5); 8.0423 (3.4); 7.7135 (3.1); 7.1457 (2.5); 7.1442 (2.4); 7.1357 (1.7); 7.1254 (3.1); 7.1239 (3.2); 6.9144 (2.3); 6.9088 (2.2); 6.8943 (1.9); 6.8886 (1.9); 4.2509 (0.5); 4.2433 (0.8); 4.2343 (0.9); 4.2255 (0.8); 4.2177 (0.6); 4.2115 (0.7); 4.1945 (1.4); 4.1775 (1.9); 4.1606 (1.4); 4.1435 (0.5); 3.6037 (1.7); 3.5875 (1.8); 3.5784 (2.1); 3.5622 (1.8); 3.3137 (135.0); 3.2637 (0.9); 3.1190 (1.6); 3.1100 (1.6); 3.0937 (1.5); 3.0848 (1.5); 2.6751 (2.1); 2.6700 (0.6); 2.6553 (2.0); 2.6335 (2.3); 2.6137 (2.0); 2.5233 (1.3); 2.5186 (1.8); 2.5100 (27.0); 2.5054 (59.2); 2.5008 (82.7); 2.4961 (57.5); 2.4915 (25.6); 2.4508 (0.6); 2.3275 (0.5); 2.2530 (0.8); 2.1429 (16.0); 2.1362 (2.6); 2.1251 (1.8); 2.0943 (1.6); 2.0835 (1.6); 1.0880 (11.0); 1.0710 (12.4); 1.0681 (12.5); 1.0510 (10.9); -0.0002 (0.9) I.4-114: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.2242 (3.7); 8.2178 (3.6); 8.1096 (1.9); 8.1055 (2.0); 8.0890 (3.9); 8.0848 (3.7); 8.0683 (2.1); 8.0641 (2.0); 7.7308 (1.5); 7.7227 (13.1); 7.7172 (3.7); 7.7055 (4.3); 7.7000 (15.2); 7.6920 (1.3); 7.4543 (1.8); 7.4463 (16.0); 7.4408 (4.1); 7.4292 (3.9); 7.4237 (13.2); 7.4157 (1.0); 7.1991 (5.0); 7.1953 (3.3); 7.1836 (3.7); 7.1786 (3.3); 7.1748 (2.9); 7.1697 (2.2); 7.1660 (2.2); 7.1493 (2.6); 7.1456 (2.6); 7.1033 (1.7); 7.0845 (3.4); 7.0642 (2.0); 6.9689 (1.5); 6.9646 (1.7); 6.9561 (1.8); 6.9515 (2.2); 6.9457 (1.8); 6.9371 (1.8); 6.9329 (1.8); 6.9256 (0.9); 6.9171 (0.8); 6.9128 (0.8); 4.4108 (1.1); 4.4042 (1.6); 4.3944 (1.8); 4.3854 (1.5); 4.3783 (1.1); 4.1604 (3.2); 4.1441 (3.2); 4.1351 (4.1); 4.1189 (2.9); 4.0381 (1.0); 4.0201 (0.9); 3.6860 (2.7); 3.6770 (2.8); 3.6606 (2.6); 3.6518 (2.5); 3.4317 (0.6); 3.3951 (0.6); 3.3619 (4.1); 3.3482 (0.7); 3.3445 (1.2); 3.3116 (309.1); 3.2842 (1.3); 3.2622 (4.4); 3.2113 (0.6); 2.9836 (3.2); 2.9641 (3.4); 2.9411 (3.8); 2.9216 (3.4); 2.6741 (1.5); 2.6696 (2.3); 2.6650 (1.6); 2.5553 (3.1); 2.5507 (4.4); 2.5461 (3.2); 2.5231 (5.3); 2.5184 (7.7); 2.5098 (128.3); 2.5052 (283.5); 2.5006 (400.5); 2.4959 (283.8); 2.4913 (129.9); 2.4601 (3.2); 2.4554 (5.1); 2.4508 (6.6); 2.4461 (5.3); 2.4419 (5.7); 2.4313 (4.1); 2.4000 (3.7); 2.3890 (3.1); 2.3321 (2.0); 2.3274 (2.5); 2.3226 (1.9); 2.0726 (2.8); 1.9879 (4.5); 1.1923 (1.3); 1.1745 (2.6); 1.1567 (1.4); 0.0499 (1.6); 0.0080 (4.6); -0.0002 (196.3); -0.0085 (7.0); -0.0500 (2.5); - 0.1497 (0.6) I.4-115: 1 H-NMR (400.0 MHz, CDCl 3 ): δ= 8.2947 (2.1); 8.2889 (2.2); 8.2818 (0.8); 8.2758 (0.7); 7.5497 (1.3); 7.5442 (1.2); 7.5384 (1.5); 7.5269 (1.7); 7.5179 (2.6); 7.3557 (0.6); 7.3125 (0.9); 7.2979 (1.1); 7.2882 (1.0); 7.2591 (305.6); 7.2292 (2.6); 7.2081 (0.7); 7.1360 (0.6); 7.1144 (0.6); 7.1082 (0.6); 7.0602 (1.8); 7.0393 (2.6); 7.0175 (1.8); 6.9951 (2.7); 6.9607 (1.3); 6.9547 (1.2); 6.9392 (1.1); 6.9332 (1.1); 5.7406 (0.6); 4.6191 (0.5); 4.2260 (0.6); 4.2104 (0.7); 4.1990 (0.8); 4.1837 (2.4); 3.8671 (0.8); 3.8417 (0.7); 3.0938 (1.0); 3.0749 (0.9); 3.0512 (0.8); 3.0320 (0.7); 2.5295 (0.7); 2.4864 (0.6); 1.5391 (34.9); 1.4150 (1.2); 1.3965 (2.0); 1.3783 (1.1); 1.3321 (11.9); 1.2831 (16.0); 1.2552 (16.0); 0.8800 (2.1); 0.8620 (1.3); 0.0688 (3.2); 0.0079 (4.1); -0.0002 (126.2); -0.0085 (5.3); -0.1498 (0.5) I.4-116: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 9.7619 (2.7); 9.2140 (8.5); 8.3127 (0.3); 8.2370 (3.1); 8.2229 (3.2); 8.1260 (8.6); 8.1118 (8.9); 7.6984 (6.6); 7.6861 (7.2); 7.6809 (4.5); 7.6755 (7.9); 7.6633 (7.4); 7.6523 (4.2); 7.6479 (4.0); 7.6018 (9.9); 7.5975 (10.4); 7.3798 (1.9); 7.3753 (1.9); 7.3658 (1.9); 7.3613 (1.9); 7.2686 (5.1); 7.2641 (5.3); 7.2543 (5.3); 7.2498 (5.7); 7.2397 (7.3); 7.2175 (12.4); 7.1954 (10.8); 7.1797 (4.7); 6.0235 (0.5); 6.0143 (0.4); 5.8449 (0.3); 5.8353 (0.4); 4.5961 (0.3); 4.4274 (1.5); 4.4194 (2.1); 4.4105 (2.3); 4.4015 (2.2); 4.3939 (1.6); 4.3735 (0.5); 4.1597 (3.5); 4.1428 (3.7); 4.1344 (4.4); 4.1175 (3.4); 3.9020 (16.0); 3.7017 (3.7); 3.6924 (3.8); 3.6763 (3.4); 3.6672 (3.4); 3.5087 (1.0); 3.4789 (0.6); 3.4661 (0.7); 3.4579 (0.8); 3.3481 (424.6); 3.2684 (2.3); 3.2523 (1.1); 3.2322 (0.5); 3.2202 (0.5); 3.1702 (11.1); 2.9536 (3.2); 2.9334 (3.4); 2.9110 (4.0); 2.8909 (3.9); 2.6730 (1.3); 2.5435 (1.9); 2.5085 (185.1); 2.5043 (242.2); 2.5000 (182.9); 2.4811 (6.9); 2.4490 (3.5); 2.4379 (3.4); 2.3355 (1.0); 2.3310 (1.3); 1.2347 (1.8); 0.0076 (0.9); -0.0002 (26.0); -0.0081 (1.2) I.4-117: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 7.8771 (1.3); 7.8722 (2.4); 7.8677 (2.1); 7.8523 (1.2); 3.3116 (8.3); 3.0960 (1.9); 3.0778 (6.1); 3.0595 (6.2); 3.0414 (2.1); 2.5232 (1.2); 2.5185 (1.8); 2.5100 (17.2); 2.5055 (34.2); 2.5009 (45.7); 2.4964 (32.1); 2.4919 (14.7); 1.2090 (7.7); 1.1908 (16.0); 1.1725 (7.4); 0.0080 (0.8); -0.0002 (18.9); -0.0085 (0.6) I.4-118: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.6630 (7.7); 7.4744 (0.8); 7.4654 (8.6); 7.4597 (2.9); 7.4530 (9.2); 7.4479 (4.8); 7.4425 (10.2); 7.4359 (3.2); 7.4301 (9.6); 7.4211 (0.9); 7.1426 (0.9); 7.1336 (9.8); 7.1279 (2.8); 7.1208 (1.3); 7.1163 (3.1); 7.1115 (16.0); 7.1062 (3.2); 7.1017 (1.1); 7.0947 (2.7); 7.0890 (8.6); 7.0799 (0.7); 3.3080 (83.7); 2.6741 (0.9); 2.6695 (1.2); 2.6649 (0.8); 2.5342 (0.7); 2.5229 (3.5); 2.5182 (4.9); 2.5096 (65.7); 2.5050 (141.4); 2.5004 (195.6); 2.4958 (137.9); 2.4913 (62.2); 2.3318 (0.8); 2.3272 (1.2); 2.3226 (0.8); 0.0080 (2.1); - 0.0002 (68.1); -0.0085 (1.9) I.4-119: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 11.5869 (4.7); 7.9095 (6.9); 7.8879 (8.1); 7.8622 (7.1); 7.8463 (16.0); 7.8394 (14.5); 7.8267 (14.5); 7.8198 (14.7); 7.8032 (5.5); 7.7327 (6.4); 7.7140 (6.7); 7.6778 (3.9); 7.6609 (6.2); 7.6397 (5.8); 7.6196 (3.0); 7.3531 (3.3); 7.3338 (4.6); 7.1686 (3.2); 4.1729 (3.0); 3.6547 (3.4); 3.5116 (4.3); 3.3121 (1279.9); 2.8937 (3.0); 2.6740 (19.0); 2.6693 (25.2); 2.6648 (18.9); 2.5227 (80.7); 2.5177 (130.0); 2.5093 (1577.5); 2.5048 (3217.1); 2.5003 (4312.8); 2.4958 (3095.8); 2.4914 (1524.0); 2.3317 (20.8); 2.3270 (26.0); 2.3228 (19.2); 2.0720 (6.8); 1.0215 (4.7); 1.0059 (4.8); 0.1463 (2.9); 0.0079 (25.3); -0.0002 (735.5); -0.0085 (35.4); -0.1493 (3.1) I.4-120: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.7114 (16.0); 8.6185 (4.5); 8.1851 (1.8); 8.1670 (2.2); 8.1445 (1.7); 8.1239 (2.5); 8.0587 (6.8); 8.0412 (7.0); 8.0291 (1.7); 8.0099 (2.4); 7.9963 (6.8); 7.8263 (9.7); 7.8059 (11.6); 7.7105 (9.3); 7.6905 (10.0); 7.6604 (5.4); 7.6408 (9.1); 7.6210 (4.5); 7.4474 (0.7); 7.3399 (6.1); 7.3209 (10.2); 7.3014 (4.8); 7.2288 (0.8); 4.2601 (1.8); 4.2424 (5.5); 4.2246 (5.9); 4.2030 (5.7); 4.1852 (5.6); 4.1674 (1.7); 3.3099 (326.0); 3.1150 (1.0); 3.0974 (1.1); 3.0848 (1.1); 2.6740 (4.1); 2.6695 (5.3); 2.6651 (3.8); 2.5093 (371.9); 2.5049 (688.9); 2.5004 (878.4); 2.4959 (608.1); 2.4914 (272.6); 2.4621 (1.2); 2.3316 (3.9); 2.3271 (4.9); 2.3226 (3.6); 2.0722 (0.9); 1.2840 (6.1); 1.2663 (12.8); 1.2487 (11.9); 1.2311 (13.2); 1.2134 (5.8); 1.1948 (2.1); 1.1767 (4.1); 1.1586 (1.9); 1.0226 (0.8); 0.1463 (1.0); 0.0077 (13.5); -0.0002 (249.3); -0.0083 (8.9); - 0.1491 (1.0) I.4-121: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.9959 (8.6); 8.9918 (9.3); 8.9853 (9.3); 8.9811 (8.9); 8.5644 (16.0); 8.5528 (7.5); 8.5490 (7.2); 8.5319 (7.2); 8.5282 (6.8); 8.0947 (9.4); 8.0735 (10.3); 8.0422 (7.9); 8.0390 (8.3); 8.0217 (9.2); 8.0186 (9.1); 7.8235 (7.5); 7.8201 (7.9); 7.8050 (11.3); 7.8017 (10.3); 7.7294 (11.7); 7.7192 (14.3); 7.7151 (12.9); 7.7097 (16.0); 7.6997 (12.2); 7.6957 (11.0); 7.6906 (8.1); 7.6795 (8.1); 7.6687 (7.9); 7.6587 (7.6); 7.6480 (7.5); 7.6207 (4.9); 7.6169 (4.7); 7.5989 (8.4); 7.5809 (4.9); 7.5770 (4.5); 7.1464 (6.1); 7.1445 (5.9); 7.1274 (10.4); 7.1085 (5.4); 7.1066 (5.0); 4.6119 (0.6); 4.5949 (1.9); 4.5828 (3.4); 4.5722 (2.9); 4.5658 (3.4); 4.5532 (2.0); 4.5364 (0.7); 4.3659 (6.3); 4.3491 (6.3); 4.3413 (7.7); 4.3246 (5.8); 3.8771 (6.4); 3.8666 (6.3); 3.8525 (5.9); 3.8421 (5.6); 3.0141 (5.7); 2.9942 (6.2); 2.9719 (7.2); 2.9521 (6.3); 2.6770 (0.7); 2.6724 (1.0); 2.6682 (0.7); 2.5516 (1.2); 2.5256 (5.0); 2.5122 (59.7); 2.5078 (121.2); 2.5035 (162.6); 2.4990 (115.8); 2.4945 (59.0); 2.4633 (5.3); 2.4508 (5.4); 2.3348 (0.8); 2.3303 (1.0); 2.3258 (0.7); 0.0079 (2.1); -0.0002 (46.8); -0.0081 (1.7) I.4-122: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.7168 (2.3); 8.0175 (6.3); 7.9967 (7.0); 7.8315 (1.5); 7.8109 (1.8); 7.7402 (11.0); 7.7198 (9.0); 7.7135 (5.0); 7.7075 (10.7); 7.7023 (6.4); 7.6971 (10.0); 7.6896 (6.1); 7.6850 (9.8); 7.6758 (1.8); 7.6601 (1.8); 7.6271 (12.2); 7.6099 (12.2); 7.5802 (6.4); 7.5607 (3.6); 7.3400 (0.9); 7.3211 (1.5); 7.3020 (0.8); 7.2570 (1.3); 7.2485 (8.8); 7.2433 (3.1); 7.2265 (16.0); 7.2163 (5.6); 7.2095 (4.4); 7.2041 (9.6); 7.1974 (7.4); 7.1785 (3.6); 4.4231 (0.6); 4.4141 (1.2); 4.4057 (2.1); 4.3975 (2.9); 4.3887 (3.2); 4.3802 (3.0); 4.3720 (2.3); 4.3634 (1.4); 4.3543 (0.8); 4.1761 (4.5); 4.1600 (4.6); 4.1508 (5.5); 4.1348 (4.4); 3.6888 (4.7); 3.6806 (4.5); 3.6634 (4.4); 3.6553 (4.2); 3.3164 (21.1); 2.9885 (4.2); 2.9692 (4.4); 2.9461 (5.2); 2.9268 (4.8); 2.5576 (0.6); 2.5533 (0.6); 2.5072 (55.5); 2.5031 (69.5); 2.4991 (50.2); 2.4316 (5.3); 2.4217 (5.1); 2.3891 (4.4); 2.3793 (4.3); 2.3302 (0.5); 1.2357 (2.0); -0.0002 (16.0); -0.0084 (0.8) I.4-123: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 9.3106 (10.7); 8.9537 (7.0); 8.9495 (7.4); 8.9434 (7.6); 8.9391 (7.1); 8.4679 (6.5); 8.4636 (6.5); 8.4471 (7.1); 8.4429 (6.7); 8.2376 (0.8); 8.2236 (0.7); 8.1388 (11.6); 8.1246 (12.3); 8.0003 (6.2); 7.9970 (6.4); 7.9800 (7.4); 7.9766 (7.2); 7.7694 (5.6); 7.7659 (5.7); 7.7509 (9.1); 7.7475 (7.9); 7.6851 (7.8); 7.6659 (9.8); 7.6464 (5.7); 7.6246 (16.0); 7.6225 (15.0); 7.6128 (7.3); 7.6025 (6.7); 7.5920 (6.5); 7.2977 (7.0); 7.2930 (6.6); 7.2835 (7.0); 7.2789 (6.5); 7.2516 (5.9); 7.2344 (6.0); 4.5778 (2.7); 4.5599 (2.9); 4.5477 (1.8); 4.5297 (0.7); 4.3478 (4.8); 4.3306 (5.0); 4.3231 (6.0); 4.3062 (4.7); 4.1007 (1.1); 4.0878 (3.3); 4.0747 (3.4); 4.0619 (1.2); 3.8783 (4.8); 3.8675 (4.8); 3.8536 (4.6); 3.8428 (4.5); 3.3119 (162.2); 3.2801 (1.4); 3.1769 (13.4); 3.1758 (16.7); 3.1638 (13.2); 3.1627 (16.2); 3.0884 (1.0); 2.9716 (4.3); 2.9516 (4.6); 2.9294 (5.5); 2.9096 (5.0); 2.6749 (1.7); 2.6704 (2.2); 2.6660 (1.6); 2.5526 (1.5); 2.5391 (6.0); 2.5250 (10.1); 2.5101 (137.4); 2.5058 (272.4); 2.5013 (357.5); 2.4970 (259.2); 2.4929 (127.5); 2.3328 (1.7); 2.3282 (2.2); 2.3239 (1.6); 2.0730 (2.1); 1.1888 (1.7); 1.1710 (2.9); 1.1533 (1.7); 0.0009 (40.6); -0.0002 (52.5); -0.0085 (2.1) I.4-124: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.7151 (2.2); 8.0209 (6.7); 8.0001 (7.4); 7.8299 (1.4); 7.8095 (1.8); 7.7370 (11.1); 7.7073 (1.7); 7.6882 (12.5); 7.6854 (15.3); 7.6805 (4.5); 7.6661 (16.0); 7.6637 (14.9); 7.6581 (3.0); 7.6369 (7.3); 7.6237 (9.7); 7.6048 (7.4); 7.5785 (5.9); 7.5591 (3.2); 7.4114 (1.6); 7.4065 (10.8); 7.4014 (3.7); 7.3932 (2.2); 7.3879 (14.5); 7.3852 (12.7); 7.3710 (3.9); 7.3664 (11.3); 7.3610 (1.6); 7.3500 (0.5); 7.3392 (1.0); 7.3200 (1.5); 7.3009 (0.7); 7.2139 (3.9); 7.1948 (6.7); 7.1757 (3.4); 7.1679 (3.3); 7.1653 (5.8); 7.1627 (3.6); 7.1468 (9.3); 7.1310 (2.4); 7.1284 (4.1); 7.1258 (2.4); 4.4236 (0.6); 4.4144 (1.2); 4.4061 (2.0); 4.3980 (2.8); 4.3892 (3.1); 4.3805 (2.9); 4.3724 (2.2); 4.3637 (1.4); 4.3547 (0.7); 4.1867 (5.9); 4.1708 (5.8); 4.1611 (7.2); 4.1453 (5.6); 3.6984 (5.1); 3.6904 (5.1); 3.6728 (4.7); 3.6649 (4.6); 3.3133 (24.2); 2.9985 (5.6); 2.9792 (6.0); 2.9561 (6.9); 2.9368 (6.2); 2.6708 (0.5); 2.5242 (1.4); 2.5195 (2.2); 2.5107 (28.2); 2.5062 (61.6); 2.5017 (86.2); 2.4971 (62.0); 2.4926 (28.9); 2.4350 (5.4); 2.4253 (5.4); 2.3926 (4.6); 2.3830 (4.6); 2.3284 (0.5); 1.2350 (2.2); 0.0080 (1.3); -0.0002 (43.3); -0.0085 (1.4) I.4-125: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.6605 (7.9); 8.4457 (4.0); 7.6992 (3.7); 7.6868 (4.0); 7.6816 (2.4); 7.6762 (4.4); 7.6638 (4.1); 7.4649 (8.3); 7.4525 (9.1); 7.4474 (5.0); 7.4421 (9.8); 7.4351 (3.3); 7.4297 (9.3); 7.4058 (3.7); 7.3934 (4.0); 7.3882 (2.1); 7.3829 (4.3); 7.3706 (4.1); 7.2359 (4.3); 7.2137 (6.4); 7.1913 (3.8); 7.1336 (9.5); 7.1278 (2.9); 7.1114 (16.0); 7.0947 (2.6); 7.0890 (8.5); 7.0786 (4.3); 7.0563 (6.8); 7.0338 (3.3); 6.7281 (2.2); 6.7111 (2.2); 4.3855 (1.2); 4.1411 (2.1); 4.1243 (2.0); 4.1163 (2.6); 4.0994 (2.0); 3.6781 (2.1); 3.6682 (2.0); 3.6528 (1.8); 3.6434 (1.7); 3.3574 (2.2); 3.3397 (2.3); 3.3072 (558.8); 3.2575 (1.0); 3.1746 (0.9); 3.1615 (0.9); 2.9329 (2.0); 2.9130 (2.1); 2.8906 (2.5); 2.8709 (2.3); 2.6738 (6.6); 2.6693 (9.1); 2.6647 (6.6); 2.5551 (3.9); 2.5513 (4.5); 2.5228 (26.7); 2.5180 (37.0); 2.5093 (512.2); 2.5048 (1095.1); 2.5002 (1516.1); 2.4957 (1073.3); 2.4911 (493.7); 2.4527 (3.1); 2.4214 (1.9); 2.4103 (2.0); 2.3317 (6.4); 2.3270 (9.2); 2.3225 (6.5); 2.3180 (3.2); 2.0719 (1.3); 0.1462 (2.8); 0.0505 (1.2); 0.0331 (1.6); 0.0079 (21.2); - 0.0002 (689.6); -0.0085 (20.9); -0.1494 (2.6) I.4-126: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.9561 (8.6); 8.9518 (9.3); 8.9457 (9.4); 8.9413 (9.1); 8.6487 (1.6); 8.5274 (11.2); 8.4636 (7.3); 8.4593 (7.5); 8.4427 (8.0); 8.4384 (7.6); 7.9966 (6.8); 7.9930 (7.5); 7.9761 (8.0); 7.9725 (8.1); 7.7685 (7.0); 7.7649 (7.6); 7.7501 (11.3); 7.7464 (10.2); 7.6837 (10.3); 7.6635 (10.7); 7.6449 (6.6); 7.6192 (8.5); 7.6088 (8.3); 7.5985 (8.1); 7.5880 (8.1); 7.4611 (2.0); 7.4582 (2.5); 7.4533 (0.8); 7.4394 (3.2); 7.4367 (2.8); 7.4231 (10.5); 7.4202 (13.2); 7.4153 (4.0); 7.4060 (4.4); 7.4013 (16.0); 7.3987 (13.9); 7.3934 (1.9); 7.2956 (2.2); 7.2905 (0.7); 7.2771 (2.7); 7.2745 (2.2); 7.2603 (1.0); 7.2555 (3.4); 7.2503 (11.7); 7.2454 (3.5); 7.2318 (14.2); 7.2292 (11.8); 7.2151 (3.6); 7.2105 (10.3); 7.2054 (1.3); 6.9855 (0.6); 6.9827 (1.0); 6.9798 (0.6); 6.9643 (1.8); 6.9487 (0.5); 6.9459 (0.9); 6.9431 (0.5); 6.9306 (3.0); 6.9278 (5.6); 6.9249 (3.2); 6.9118 (4.5); 6.9094 (9.4); 6.9071 (4.7); 6.8939 (2.5); 6.8910 (4.5); 6.8882 (2.4); 6.8165 (6.0); 6.7992 (6.1); 4.5954 (0.5); 4.5823 (1.1); 4.5783 (1.4); 4.5714 (1.4); 4.5654 (2.8); 4.5589 (2.1); 4.5543 (2.1); 4.5480 (2.9); 4.5350 (1.6); 4.5307 (1.3); 4.5178 (0.7); 4.3426 (6.0); 4.3257 (6.2); 4.3181 (7.6); 4.3013 (5.6); 3.8545 (5.5); 3.8436 (5.4); 3.8300 (5.1); 3.8191 (4.9); 3.3147 (45.9); 2.9632 (5.4); 2.9433 (6.0); 2.9212 (6.9); 2.9014 (6.0); 2.6706 (0.7); 2.5241 (1.9); 2.5194 (2.9); 2.5107 (38.1); 2.5061 (83.8); 2.5016 (119.0); 2.4969 (82.4); 2.4923 (39.1); 2.4609 (4.8); 2.4479 (4.7); 2.3329 (0.5); 2.3284 (0.7); 2.3237 (0.5); 1.2338 (1.3); 0.0080 (1.0); -0.0002 (35.3); -0.0085 (1.1) I.4-127: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 9.1886 (4.7); 8.6684 (1.3); 8.6553 (1.3); 8.2365 (1.1); 8.2224 (1.1); 8.1255 (6.0); 8.1113 (6.2); 7.8990 (4.3); 7.8935 (1.8); 7.8820 (2.7); 7.8763 (13.0); 7.8525 (13.3); 7.8468 (2.8); 7.8352 (2.0); 7.8299 (4.2); 7.6955 (1.2); 7.6918 (1.4); 7.6534 (1.2); 7.6488 (1.2); 7.5981 (5.9); 7.5935 (6.1); 7.5862 (1.0); 7.5772 (0.9); 7.5728 (0.9); 7.3840 (0.8); 7.3792 (0.7); 7.3699 (0.7); 7.3651 (0.7); 7.2689 (3.6); 7.2641 (3.4); 7.2546 (3.4); 7.2498 (3.4); 7.1902 (2.5); 7.1736 (2.5); 4.4450 (1.1); 4.4361 (1.2); 4.4265 (1.1); 4.4195 (0.8); 4.2048 (2.1); 4.1878 (2.2); 4.1792 (2.6); 4.1622 (2.0); 3.7694 (2.0); 3.7600 (2.0); 3.7439 (1.8); 3.7342 (1.8); 3.7199 (0.8); 3.3613 (0.6); 3.3567 (0.6); 3.3435 (0.6); 3.3088 (186.4); 3.0206 (2.1); 3.0003 (2.3); 2.9776 (2.6); 2.9573 (2.3); 2.6743 (1.5); 2.6696 (2.1); 2.6651 (1.5); 2.5584 (2.3); 2.5472 (3.1); 2.5230 (5.8); 2.5182 (8.9); 2.5096 (118.7); 2.5051 (255.8); 2.5006 (354.0); 2.4960 (250.7); 2.4915 (115.2); 2.4406 (0.6); 2.3320 (1.6); 2.3274 (2.1); 2.3228 (1.5); 2.1959 (0.5); 2.1774 (1.1); 2.1588 (0.6); 1.2358 (16.0); 1.0906 (0.7); 0.8701 (0.6); 0.8623 (0.6); 0.8539 (2.1); 0.8363 (0.9); 0.0080 (1.3); -0.0002 (43.8); -0.0085 (1.4) I.4-127: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 9.8930 (0.7); 9.2858 (3.8); 8.6685 (0.9); 8.6549 (1.0); 8.2350 (1.2); 8.2209 (1.2); 8.1246 (5.1); 8.1104 (5.5); 7.8990 (3.7); 7.8819 (2.2); 7.8763 (11.0); 7.8516 (10.9); 7.8294 (3.6); 7.7046 (1.0); 7.7003 (1.1); 7.6466 (1.1); 7.6419 (1.2); 7.5976 (5.2); 7.5930 (5.6); 7.5819 (0.8); 7.5776 (0.7); 7.3735 (0.7); 7.3689 (0.7); 7.3596 (0.6); 7.3547 (0.7); 7.2698 (3.1); 7.2650 (3.0); 7.2555 (3.1); 7.2507 (3.2); 7.2409 (2.1); 7.2245 (2.1); 4.4350 (1.1); 4.2057 (1.9); 4.1886 (1.9); 4.1800 (2.3); 4.1632 (1.7); 4.0387 (0.8); 4.0210 (0.9); 3.7700 (1.8); 3.7604 (1.7); 3.7442 (1.6); 3.7349 (1.5); 3.3464 (3.2); 3.1215 (1.1); 3.1092 (1.2); 3.1032 (3.5); 3.0912 (3.4); 3.0850 (3.6); 3.0730 (3.5); 3.0670 (1.2); 3.0548 (1.1); 3.0210 (1.8); 3.0007 (2.0); 2.9780 (2.3); 2.9576 (2.1); 2.6707 (0.6); 2.5573 (2.3); 2.5465 (3.0); 2.5241 (2.2); 2.5106 (39.6); 2.5061 (84.0); 2.5016 (116.1); 2.4970 (80.7); 2.4925 (36.2); 2.3287 (0.6); 1.9882 (3.5); 1.9091 (11.3); 1.2352 (4.4); 1.2025 (7.7); 1.1930 (1.5); 1.1843 (16.0); 1.1751 (2.4); 1.1661 (7.5); 1.1573 (1.1); 0.8533 (0.7); 0.0081 (1.3); -0.0002 (39.9); -0.0085 (1.1) I.4-128: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.6633 (7.3); 8.4637 (5.8); 7.8999 (5.6); 7.8770 (16.0); 7.8492 (15.7); 7.8264 (6.1); 7.4652 (7.9); 7.4530 (8.6); 7.4476 (4.8); 7.4424 (10.0); 7.4301 (9.2); 7.4047 (5.2); 7.3925 (5.6); 7.3817 (6.8); 7.3694 (6.1); 7.1336 (9.4); 7.1114 (15.6); 7.0890 (8.4); 7.0781 (6.9); 7.0558 (10.2); 7.0336 (5.5); 6.7475 (3.1); 6.7308 (3.4); 4.1880 (2.8); 4.1706 (3.0); 4.1620 (3.4); 4.1451 (3.2); 3.7455 (3.0); 3.7206 (2.3); 3.7097 (2.3); 3.3080 (256.1); 3.0014 (2.7); 2.9816 (2.9); 2.9587 (3.5); 2.9387 (3.1); 2.6691 (3.5); 2.5555 (2.2); 2.5337 (3.6); 2.5228 (10.4); 2.5183 (11.7); 2.5095 (205.2); 2.5049 (458.1); 2.5003 (647.4); 2.4957 (459.1); 2.4912 (211.7); 2.4505 (3.0); 2.3273 (3.6); 0.0081 (5.0); -0.0002 (169.5); -0.0086 (5.0) I.4-129: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.4363 (6.3); 8.0675 (4.1); 8.0461 (4.3); 7.9110 (5.7); 7.8939 (3.3); 7.8882 (16.0); 7.8611 (15.9); 7.8554 (3.4); 7.8438 (2.3); 7.8384 (5.8); 7.7013 (3.7); 7.6978 (3.9); 7.6821 (3.9); 7.6781 (4.3); 7.6252 (3.2); 7.6091 (5.0); 7.5915 (3.6); 7.5734 (2.1); 7.5694 (1.9); 7.1401 (2.9); 7.1374 (2.8); 7.1187 (4.6); 7.1020 (2.5); 7.0993 (2.4); 4.4259 (1.6); 4.2188 (2.7); 4.2023 (2.8); 4.1929 (3.2); 4.1768 (2.4); 3.7790 (2.4); 3.7709 (2.4); 3.7541 (2.2); 3.7460 (2.2); 3.3107 (160.2); 3.0529 (2.6); 3.0333 (2.9); 3.0101 (3.1); 2.9902 (2.9); 2.6698 (1.4); 2.5400 (4.9); 2.5236 (4.7); 2.5100 (83.8); 2.5054 (182.6); 2.5008 (255.0); 2.4962 (180.0); 2.4917 (81.2); 2.4734 (2.8); 2.3274 (1.5); 2.0725 (2.0); 0.0081 (1.6); -0.0002 (58.8); - 0.0085 (1.6) I.4-130: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.4283 (12.0); 8.0794 (8.4); 8.0584 (8.9); 7.7119 (8.3); 7.6992 (15.5); 7.6890 (10.2); 7.6771 (16.0); 7.6252 (6.2); 7.6088 (9.4); 7.5908 (6.8); 7.5697 (3.7); 7.2468 (8.6); 7.2239 (15.0); 7.2025 (7.9); 7.1348 (5.1); 7.1148 (7.9); 7.0959 (4.2); 4.4066 (3.7); 4.1760 (4.2); 4.1605 (4.9); 4.1501 (5.6); 4.1342 (4.3); 3.7042 (5.3); 3.6791 (5.1); 3.3115 (355.7); 2.9868 (4.3); 2.9669 (5.0); 2.9441 (5.2); 2.9239 (5.0); 2.6700 (3.6); 2.5003 (611.3); 2.4519 (7.0); 2.4423 (6.4); 2.4098 (4.6); 2.3991 (4.7); 2.3278 (3.6); -0.0002 (72.8) I.4-131: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 9.1892 (10.8); 8.1259 (13.9); 8.1117 (14.4); 7.6675 (11.4); 7.6647 (14.5); 7.6455 (16.0); 7.6431 (14.0); 7.6057 (14.5); 7.6012 (14.7); 7.3962 (10.9); 7.3911 (3.7); 7.3775 (14.9); 7.3607 (4.0); 7.3561 (10.8); 7.2716 (8.8); 7.2668 (8.5); 7.2574 (8.4); 7.2526 (8.3); 7.2038 (5.6); 7.1869 (5.6); 7.1580 (5.7); 7.1395 (9.4); 7.1210 (4.1); 4.4338 (1.9); 4.4261 (2.6); 4.4169 (3.1); 4.4080 (2.8); 4.4004 (2.0); 4.3805 (0.7); 4.1715 (5.7); 4.1546 (5.8); 4.1460 (7.0); 4.1292 (5.5); 3.7176 (5.4); 3.7083 (5.3); 3.6922 (4.9); 3.6830 (4.7); 2.9624 (5.5); 2.9422 (5.9); 2.9198 (7.0); 2.8998 (6.3); 2.6716 (0.7); 2.5248 (1.9); 2.5115 (40.1); 2.5070 (87.8); 2.5025 (127.2); 2.4979 (88.3); 2.4933 (44.2); 2.4604 (4.7); 2.4492 (4.9); 2.3297 (0.7); - 0.0002 (9.4) I.4-132: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.4251 (10.2); 8.0863 (6.5); 8.0656 (7.1); 7.6996 (5.8); 7.6959 (6.6); 7.6810 (14.9); 7.6786 (16.0); 7.6769 (14.2); 7.6593 (14.1); 7.6568 (12.0); 7.6511 (1.8); 7.6366 (5.1); 7.6201 (5.2); 7.6122 (4.2); 7.6081 (3.7); 7.5934 (4.4); 7.5901 (5.9); 7.5869 (3.8); 7.5722 (3.6); 7.5682 (3.3); 7.4097 (1.4); 7.4048 (9.7); 7.3996 (3.0); 7.3916 (1.9); 7.3862 (12.8); 7.3833 (10.4); 7.3693 (3.4); 7.3646 (9.8); 7.3592 (1.3); 7.1667 (2.7); 7.1640 (5.0); 7.1614 (2.8); 7.1456 (8.3); 7.1350 (5.0); 7.1323 (5.3); 7.1300 (2.8); 7.1272 (4.0); 7.1245 (2.3); 7.1160 (7.7); 7.1135 (7.6); 7.0970 (4.4); 7.0943 (4.3); 4.4368 (0.5); 4.4270 (1.0); 4.4187 (1.7); 4.4105 (2.3); 4.4019 (2.6); 4.3927 (2.4); 4.3849 (1.8); 4.3760 (1.1); 4.3666 (0.6); 4.1888 (5.1); 4.1728 (5.1); 4.1633 (6.2); 4.1473 (4.8); 3.7169 (4.4); 3.7089 (4.3); 3.6914 (4.0); 3.6834 (3.9); 3.3624 (2.1); 3.3437 (0.6); 3.3119 (343.1); 3.2885 (0.6); 3.2633 (1.4); 2.9976 (4.9); 2.9781 (5.2); 2.9551 (6.0); 2.9357 (5.4); 2.6744 (1.2); 2.6698 (1.7); 2.6652 (1.2); 2.5601 (0.8); 2.5553 (1.2); 2.5507 (1.5); 2.5460 (0.9); 2.5232 (4.7); 2.5186 (6.8); 2.5099 (97.0); 2.5053 (211.0); 2.5007 (294.3); 2.4961 (207.3); 2.4916 (94.6); 2.4591 (5.3); 2.4492 (4.6); 2.4166 (3.8); 2.4068 (4.0); 2.3321 (1.2); 2.3275 (1.7); 2.3228 (1.2); 2.0723 (1.0); 1.9879 (0.8); 1.2352 (0.8); 1.1746 (0.5); 0.0080 (1.6); -0.0002 (53.5); -0.0085 (1.5) I.4-133: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.6353 (1.2); 8.3708 (2.4); 7.4613 (1.6); 7.4585 (1.8); 7.4537 (0.6); 7.4396 (2.1); 7.4370 (1.9); 7.3892 (2.4); 7.3864 (3.1); 7.3816 (0.9); 7.3676 (3.8); 7.3650 (3.3); 7.2949 (1.6); 7.2764 (2.0); 7.2741 (1.6); 7.2597 (0.5); 7.2552 (1.4); 7.2365 (2.7); 7.2315 (0.9); 7.2179 (3.5); 7.2156 (2.8); 7.2103 (0.7); 7.2012 (0.9); 7.1967 (2.3); 6.9821 (0.7); 6.9637 (1.2); 6.9615 (0.6); 6.9453 (0.6); 6.9191 (0.7); 6.9163 (1.3); 6.9135 (0.9); 6.8980 (2.2); 6.8956 (1.1); 6.8824 (0.6); 6.8796 (1.0); 6.8768 (0.5); 6.5411 (1.3); 6.5241 (1.3); 4.2503 (0.7); 4.2416 (0.6); 4.2327 (0.7); 4.1903 (1.1); 4.1733 (1.5); 4.1564 (1.1); 3.5918 (1.4); 3.5749 (1.5); 3.5667 (1.7); 3.5499 (1.5); 3.3282 (0.6); 3.3213 (6.2); 3.1112 (1.4); 3.1012 (1.4); 3.0861 (1.3); 3.0762 (1.3); 2.6329 (1.5); 2.6127 (1.6); 2.5913 (1.8); 2.5711 (1.7); 2.5104 (3.8); 2.5059 (8.2); 2.5013 (11.4); 2.4967 (8.0); 2.4922 (3.7); 2.1717 (1.5); 2.1596 (1.5); 2.1301 (1.3); 2.1180 (1.3); 1.2347 (0.7); 1.1018 (0.5); 1.0805 (9.0); 1.0641 (16.0); 1.0476 (8.7) I.4-134: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 8.6754 (7.9); 7.4657 (8.3); 7.4600 (2.9); 7.4533 (8.8); 7.4481 (4.8); 7.4428 (9.8); 7.4361 (3.2); 7.4305 (9.2); 7.4218 (0.9); 7.1424 (1.0); 7.1335 (9.5); 7.1279 (2.8); 7.1114 (16.0); 7.0946 (2.5); 7.0890 (8.3); 7.0546 (0.6); 3.3091 (56.3); 2.6693 (0.9); 2.5232 (2.4); 2.5184 (3.6); 2.5096 (55.4); 2.5051 (120.2); 2.5005 (167.8); 2.4960 (118.8); 2.4915 (54.5); 2.3275 (0.9); 1.2354 (4.0); 1.0762 (1.0); 1.0600 (1.4); 1.0446 (0.9); 0.0080 (1.3); -0.0002 (43.8); -0.0086 (1.4) I.4-135: 1 H-NMR (400.0 MHz, CDCl3): δ= 8.3320 (3.6); 8.3300 (3.7); 8.3212 (0.6); 8.3098 (3.8); 8.3073 (3.5); 7.7105 (3.8); 7.5480 (1.4); 7.5441 (2.2); 7.5349 (3.7); 7.5305 (5.1); 7.5257 (4.5); 7.5217 (1.6); 7.5155 (4.0); 7.5113 (4.7); 7.5071 (2.8); 7.5031 (1.0); 7.2620 (36.2); 7.1388 (1.6); 7.1229 (1.6); 7.0512 (2.4); 7.0488 (2.4); 7.0323 (3.7); 7.0298 (4.1); 7.0132 (2.1); 7.0107 (2.0); 4.5123 (0.6); 4.4950 (1.4); 4.4816 (1.4); 4.4642 (0.6); 4.4315 (0.7); 4.4145 (1.8); 4.3976 (2.5); 4.3807 (1.8); 4.3637 (0.7); 3.6972 (2.2); 3.6835 (2.3); 3.6702 (2.8); 3.6565 (2.5); 3.4070 (2.6); 3.4029 (2.5); 3.3801 (2.2); 3.3760 (2.1); 2.9208 (2.1); 2.9022 (2.2); 2.8782 (2.6); 2.8597 (2.3); 2.2891 (2.2); 2.2838 (2.2); 2.2466 (2.0); 2.2413 (1.9); 1.1669 (15.6); 1.1579 (15.9); 1.1500 (16.0); 1.1409 (15.1); -0.0002 (13.8) I.4-136: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 9.1709 (0.9); 8.7109 (16.0); 7.8263 (9.3); 7.8057 (11.6); 7.7288 (0.8); 7.7102 (9.3); 7.7073 (9.7); 7.6904 (9.7); 7.6874 (10.3); 7.6601 (5.2); 7.6408 (8.7); 7.6214 (4.4); 7.5493 (0.5); 7.5052 (0.7); 7.4853 (0.6); 7.4551 (0.6); 7.3395 (6.2); 7.3205 (9.9); 7.3014 (4.7); 4.2794 (2.8); 3.3410 (0.5); 3.3075 (184.8); 3.1624 (0.5); 2.6787 (0.8); 2.6741 (1.7); 2.6695 (2.4); 2.6649 (1.7); 2.6602 (0.8); 2.6198 (0.6); 2.5635 (0.5); 2.5365 (1.5); 2.5318 (1.9); 2.5229 (7.8); 2.5182 (10.7); 2.5095 (126.4); 2.5050 (271.8); 2.5004 (378.3); 2.4957 (264.2); 2.4912 (117.7); 2.4498 (0.7); 2.4450 (0.6); 2.3365 (0.7); 2.3319 (1.5); 2.3272 (2.2); 2.3226 (1.5); 2.3180 (0.7); 2.0721 (0.9); 1.2357 (2.0); 1.0202 (0.5); 0.0080 (2.8); -0.0002 (92.7); - 0.0085 (2.6) I.4-137: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 9.1350 (0.7); 9.1302 (0.7); 8.8737 (0.6); 8.8588 (0.6); 7.7353 (0.5); 7.7283 (0.5); 7.7203 (0.5); 7.7132 (0.5); 7.6996 (0.7); 7.6872 (0.8); 7.6787 (1.7); 7.6664 (1.8); 7.6558 (1.7); 7.6436 (1.6); 7.2727 (1.7); 7.2506 (2.7); 7.2392 (1.0); 7.2337 (0.7); 7.2282 (1.6); 7.2171 (1.3); 7.1945 (0.7); 4.2182 (0.5); 4.2079 (0.5); 4.1909 (0.5); 3.7757 (0.6); 3.7474 (0.6); 3.3101 (36.0); 3.1047 (1.9); 3.0865 (6.2); 3.0683 (6.4); 3.0501 (2.1); 3.0229 (0.6); 2.9990 (0.7); 2.9782 (0.6); 2.6742 (0.7); 2.6697 (1.0); 2.6650 (0.7); 2.5605 (0.7); 2.5537 (0.8); 2.5230 (2.9); 2.5182 (4.6); 2.5096 (59.4); 2.5051 (125.4); 2.5005 (172.3); 2.4960 (121.2); 2.4915 (55.0); 2.4450 (0.6); 2.3320 (0.8); 2.3274 (1.0); 2.3227 (0.8); 2.0725 (0.6); 1.2035 (7.7); 1.1853 (16.0); 1.1671 (7.4); 0.0080 (2.3); -0.0002 (67.2); -0.0086 (1.8) I.4-138: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 3.3134 (3.7); 3.0912 (0.8); 3.0735 (2.4); 3.0642 (2.8); 3.0557 (2.6); 3.0462 (2.7); 3.0282 (0.9); 2.5057 (15.3); 2.5013 (20.4); 2.4969 (15.2); 1.2141 (7.9); 1.1959 (16.0); 1.1777 (7.6); -0.0002 (5.5) I.4-139: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 9.3080 (2.9); 8.3646 (0.7); 8.3487 (0.7); 7.6715 (2.2); 7.6518 (2.6); 7.6447 (1.4); 7.6235 (1.1); 7.5008 (2.8); 7.4959 (1.3); 7.4796 (5.4); 7.4748 (1.2); 7.4664 (2.0); 7.4611 (5.2); 7.4557 (0.9); 7.4031 (2.4); 7.3926 (6.4); 7.3894 (8.4); 7.3839 (5.4); 7.3734 (4.6); 7.3707 (5.7); 7.3683 (5.4); 7.3632 (3.4); 7.3524 (2.5); 7.3495 (2.6); 7.3312 (3.5); 7.3158 (1.0); 7.3130 (1.4); 7.2283 (0.8); 7.2098 (1.2); 7.1914 (0.7); 7.1798 (1.0); 7.1735 (5.0); 7.1677 (2.4); 7.1611 (2.0); 7.1550 (5.7); 7.1515 (7.5); 7.1460 (3.1); 7.1401 (3.8); 7.1339 (6.2); 7.1271 (2.0); 7.1205 (1.8); 6.8720 (1.4); 6.7752 (2.5); 6.7728 (2.3); 6.7589 (9.7); 6.7578 (10.0); 6.7434 (3.2); 6.7381 (12.8); 6.7306 (0.8); 6.6296 (0.6); 4.1846 (0.6); 4.1674 (0.6); 4.1591 (0.7); 4.1419 (0.5); 3.7724 (0.8); 3.7639 (0.8); 3.7469 (0.7); 3.7382 (0.6); 3.3160 (2.2); 2.9689 (0.6); 2.9483 (0.6); 2.9259 (0.7); 2.9057 (0.7); 2.7984 (0.7); 2.7926 (0.6); 2.7796 (0.7); 2.5644 (0.7); 2.5540 (0.8); 2.5217 (2.2); 2.5087 (18.2); 2.5044 (35.2); 2.5000 (47.4); 2.4955 (34.3); 2.4910 (16.7); 2.3321 (0.5); 2.3227 (0.6); 2.1837 (2.2); 1.3572 (16.0); 1.0835 (1.5); 1.0655 (3.0); 1.0475 (1.4); 0.0079 (0.9); -0.0002 (19.6); -0.0084 (0.9) I.4-140: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 9.2974 (0.6); 9.1280 (0.7); 9.1209 (0.7); 8.8690 (0.7); 8.8546 (0.7); 7.7300 (0.5); 7.7226 (0.6); 7.7147 (0.5); 7.7076 (0.5); 3.3106 (22.5); 3.1012 (1.3); 3.0848 (3.0); 3.0668 (3.0); 3.0491 (1.1); 2.6697 (0.5); 2.6247 (0.5); 2.5830 (0.6); 2.5097 (28.6); 2.5052 (59.6); 2.5007 (81.0); 2.4962 (57.0); 2.4917 (26.3); 1.2054 (7.7); 1.1872 (16.0); 1.1690 (7.4); 1.0809 (2.5); 1.0641 (4.8); 1.0473 (2.5); 0.0079 (1.1); -0.0002 (32.5); -0.0087 (1.1) I.4-141: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 8.6358 (5.4); 8.4050 (6.1); 7.7035 (5.8); 7.6980 (2.1); 7.6911 (6.0); 7.6857 (3.4); 7.6804 (6.6); 7.6738 (2.2); 7.6680 (6.3); 7.4787 (0.7); 7.4585 (6.5); 7.4557 (8.0); 7.4368 (9.4); 7.4344 (8.4); 7.3925 (5.6); 7.3897 (7.2); 7.3709 (8.8); 7.3684 (7.9); 7.2947 (6.7); 7.2761 (8.8); 7.2550 (6.0); 7.2373 (12.3); 7.2322 (3.8); 7.2156 (16.0); 7.1978 (7.0); 7.1928 (6.8); 6.9821 (3.1); 6.9637 (5.3); 6.9453 (2.4); 6.9199 (2.8); 6.9015 (4.9); 6.8831 (2.2); 6.7300 (3.3); 6.7135 (3.3); 4.4004 (1.6); 4.3915 (1.7); 4.1479 (3.1); 4.1311 (3.2); 4.1227 (3.7); 4.1060 (3.1); 3.6820 (3.0); 3.6727 (2.8); 3.6570 (2.7); 3.6476 (2.6); 3.3453 (1.1); 3.3275 (1.4); 3.3122 (35.1); 2.9412 (3.1); 2.9214 (3.1); 2.8987 (3.6); 2.8789 (3.4); 2.6696 (0.8); 2.5095 (47.3); 2.5050 (100.9); 2.5005 (139.8); 2.4959 (100.0); 2.4914 (46.6); 2.4631 (3.2); 2.4517 (3.2); 2.4208 (2.6); 2.4090 (2.6); 2.3272 (0.9); 1.2353 (6.3); 1.1008 (1.2); 1.0831 (2.7); 1.0654 (1.3); 0.8538 (0.6); 0.0080 (1.4); -0.0002 (38.9); -0.0085 (1.3) I.5-1: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 9.2201 (6.9); 8.7836 (3.8); 7.9418 (2.9); 7.6727 (11.5); 7.6698 (14.2); 7.6507 (16.0); 7.6482 (13.6); 7.6213 (2.5); 7.6022 (2.5); 7.5340 (13.3); 7.5124 (15.7); 7.4075 (11.8); 7.3889 (15.2); 7.3674 (11.3); 7.2935 (4.5); 7.2780 (3.8); 7.1680 (6.1); 7.1495 (9.8); 7.1311 (4.3); 4.9235 (2.1); 4.2620 (5.2); 4.2456 (6.0); 4.2360 (6.5); 4.2193 (5.6); 3.7946 (3.6); 3.7753 (3.3); 3.3103 (443.5); 3.0661 (4.6); 3.0463 (4.9); 3.0231 (6.2); 3.0030 (5.0); 2.6741 (4.9); 2.6694 (7.5); 2.6650 (5.2); 2.5532 (4.5); 2.5229 (19.8); 2.5182 (30.2); 2.5096 (409.3); 2.5050 (881.5); 2.5004 (1225.5); 2.4958 (857.8); 2.4912 (387.8); 2.4511 (1.9); 2.3316 (5.3); 2.3273 (7.2); 2.3226 (5.0); 0.0079 (5.2); -0.0002 (164.3); -0.0087 (4.8) I.5-2: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 9.2290 (4.3); 8.7822 (2.0); 8.7658 (2.0); 7.9321 (1.5); 7.7130 (0.6); 7.7039 (6.5); 7.6980 (2.2); 7.6915 (6.9); 7.6861 (3.5); 7.6806 (7.3); 7.6742 (2.3); 7.6683 (6.9); 7.6591 (0.6); 7.5355 (9.1); 7.5140 (10.9); 7.3027 (2.8); 7.2964 (2.7); 7.2811 (2.3); 7.2748 (2.3); 7.2590 (0.8); 7.2498 (7.4); 7.2440 (2.2); 7.2375 (1.0); 7.2323 (2.5); 7.2279 (10.2); 7.2226 (2.4); 7.2177 (0.9); 7.2110 (2.0); 7.2052 (6.5); 7.1960 (0.5); 5.7536 (10.4); 4.9251 (0.9); 4.2515 (3.0); 4.2350 (3.4); 4.2256 (3.8); 4.2091 (3.0); 4.0559 (1.0); 4.0382 (3.2); 4.0204 (3.2); 4.0026 (1.1); 3.7848 (2.0); 3.7771 (2.0); 3.7589 (1.8); 3.7514 (1.8); 3.3104 (106.0); 3.0552 (2.7); 3.0349 (3.0); 3.0121 (3.4); 2.9920 (3.0); 2.6742 (1.1); 2.6697 (1.5); 2.6650 (1.1); 2.6604 (0.5); 2.5541 (1.6); 2.5452 (1.9); 2.5231 (4.3); 2.5184 (6.6); 2.5098 (84.5); 2.5052 (181.9); 2.5006 (253.4); 2.4959 (175.6); 2.4914 (78.1); 2.4503 (0.6); 2.3367 (0.5); 2.3321 (1.1); 2.3273 (1.5); 2.3227 (1.1); 1.9880 (16.0); 1.2409 (0.5); 1.1923 (4.4); 1.1746 (8.7); 1.1568 (4.2); 0.8583 (0.9); 0.0081 (0.9); -0.0002 (30.6); -0.0086 (0.8) I.5-3: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 9.2489 (6.6); 8.7537 (3.2); 8.7375 (3.0); 7.9037 (2.7); 7.5385 (13.3); 7.5170 (16.0); 7.4953 (6.6); 7.4896 (7.6); 7.4699 (7.5); 7.4644 (6.2); 7.3093 (4.4); 7.3026 (4.1); 7.2876 (4.0); 7.2810 (3.4); 7.0421 (2.5); 7.0246 (2.8); 7.0190 (4.6); 6.9962 (2.8); 4.9496 (1.7); 4.2414 (3.9); 4.2243 (4.3); 4.2149 (4.7); 4.1979 (4.3); 4.0383 (1.8); 4.0202 (1.8); 3.8064 (2.9); 3.7735 (2.8); 3.3594 (1.8); 3.3083 (609.9); 3.2576 (2.8); 3.1119 (4.0); 3.0915 (4.1); 3.0682 (4.4); 3.0481 (4.4); 2.6740 (6.0); 2.6693 (8.4); 2.6647 (6.0); 2.5986 (3.3); 2.5561 (4.0); 2.5228 (28.8); 2.5181 (42.2); 2.5095 (496.7); 2.5049 (1056.8); 2.5003 (1452.4); 2.4957 (1002.6); 2.4910 (442.6); 2.4548 (3.1); 2.4500 (4.2); 2.3317 (5.9); 2.3270 (8.5); 2.3225 (5.9); 2.0721 (2.0); 1.9877 (8.7); 1.2459 (2.4); 1.1922 (2.4); 1.1745 (4.8); 1.1567 (2.3); 0.8584 (4.1); 0.8410 (1.4); -0.0002 (50.0) I.5-5: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 9.2424 (3.5); 8.5766 (0.9); 7.6962 (1.0); 7.6688 (5.8); 7.6628 (5.7); 7.5022 (0.6); 7.4906 (2.9); 7.4849 (3.4); 7.4653 (3.5); 7.4597 (2.9); 7.4218 (3.4); 7.4157 (3.2); 7.4002 (3.0); 7.3941 (2.9); 7.0442 (0.6); 7.0389 (1.0); 7.0212 (1.2); 7.0154 (2.1); 7.0099 (1.0); 6.9981 (0.7); 6.9924 (1.1); 4.9746 (0.6); 4.2310 (1.7); 4.2136 (1.9); 4.2046 (2.2); 4.1873 (1.7); 4.0558 (1.0); 4.0380 (3.3); 4.0203 (3.3); 4.0024 (1.2); 3.7829 (1.2); 3.7749 (1.2); 3.7565 (1.1); 3.7490 (1.0); 3.3114 (79.6); 3.0911 (1.8); 3.0704 (2.0); 3.0476 (2.3); 3.0270 (2.0); 2.6743 (0.9); 2.6696 (1.3); 2.6651 (1.0); 2.5937 (1.1); 2.5847 (1.1); 2.5497 (1.5); 2.5401 (1.6); 2.5231 (4.2); 2.5185 (5.8); 2.5098 (75.4); 2.5052 (163.5); 2.5006 (227.6); 2.4959 (159.4); 2.4913 (71.0); 2.3319 (1.0); 2.3273 (1.3); 2.3227 (1.0); 1.9880 (16.0); 1.2462 (1.2); 1.1923 (4.4); 1.1745 (9.1); 1.1567 (4.5); 0.8754 (0.6); 0.8583 (2.4); 0.8407 (0.8); -0.0002 (8.6) I.5-6: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 9.1549 (3.1); 8.3213 (0.6); 8.1436 (3.0); 8.1406 (3.2); 8.0287 (1.3); 8.0228 (1.3); 8.0199 (1.3); 8.0134 (2.0); 8.0090 (1.2); 8.0050 (1.4); 7.9992 (1.3); 7.6172 (0.7); 7.6140 (0.8); 7.6067 (6.1); 7.6045 (5.7); 7.5981 (2.8); 7.5948 (2.9); 7.5916 (3.3); 7.4133 (2.2); 7.2706 (2.0); 7.2499 (3.8); 7.2121 (2.7); 7.2066 (2.5); 7.1917 (1.3); 7.1862 (1.3); 5.7532 (12.9); 5.0027 (0.5); 4.2658 (1.4); 4.2485 (1.6); 4.2399 (1.8); 4.2227 (1.4); 4.0558 (0.6); 4.0381 (1.9); 4.0203 (1.9); 4.0025 (0.6); 3.8159 (1.1); 3.8072 (1.2); 3.7900 (1.1); 3.7813 (1.0); 3.3103 (74.5); 3.0631 (1.4); 3.0422 (1.6); 3.0197 (1.9); 2.9989 (1.7); 2.6740 (0.6); 2.6695 (0.9); 2.6648 (0.6); 2.6076 (1.2); 2.5972 (1.3); 2.5635 (1.5); 2.5528 (1.6); 2.5475 (1.3); 2.5228 (5.5); 2.5182 (6.9); 2.5095 (52.0); 2.5050 (107.5); 2.5004 (147.1); 2.4958 (103.8); 2.4912 (47.7); 2.4557 (0.9); 2.4511 (1.0); 2.4464 (0.8); 2.3318 (0.7); 2.3272 (0.9); 2.3226 (0.7); 2.1454 (16.0); 1.9878 (8.7); 1.2420 (1.9); 1.1923 (2.4); 1.1745 (4.7); 1.1567 (2.3); 0.8752 (0.7); 0.8583 (2.3); 0.8406 (1.0); -0.0002 (6.2) I.5-7: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 9.1215 (2.8); 8.3354 (0.6); 7.6978 (3.5); 7.6919 (1.2); 7.6855 (3.8); 7.6800 (1.9); 7.6745 (4.1); 7.6681 (1.2); 7.6622 (3.8); 7.4298 (1.7); 7.2670 (2.0); 7.2460 (4.0); 7.2422 (4.4); 7.2362 (1.2); 7.2297 (0.6); 7.2246 (1.4); 7.2202 (5.4); 7.2148 (1.4); 7.2075 (2.8); 7.2023 (3.1); 7.1974 (3.8); 7.1873 (1.5); 7.1815 (1.3); 5.7533 (3.6); 4.2276 (1.5); 4.2104 (1.8); 4.2020 (2.0); 4.1848 (1.6); 3.7605 (1.1); 3.7521 (1.2); 3.7350 (1.0); 3.7265 (1.0); 3.3098 (40.4); 3.0132 (1.5); 2.9924 (1.7); 2.9702 (2.0); 2.9494 (1.8); 2.6694 (0.6); 2.5599 (0.9); 2.5494 (1.0); 2.5229 (2.1); 2.5181 (3.4); 2.5095 (34.5); 2.5050 (73.6); 2.5003 (102.0); 2.4957 (70.9); 2.4911 (31.3); 2.3272 (0.6); 2.1432 (16.0); -0.0002 (13.0) I.5-8: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 9.2171 (3.0); 8.6059 (0.8); 8.5923 (0.8); 7.7078 (0.9); 7.6986 (4.4); 7.6928 (1.9); 7.6863 (4.3); 7.6809 (2.2); 7.6754 (4.3); 7.6689 (1.7); 7.6636 (7.8); 7.6580 (4.8); 7.4179 (3.1); 7.4118 (2.9); 7.3963 (2.7); 7.3902 (2.6); 7.2456 (4.2); 7.2398 (1.2); 7.2332 (0.6); 7.2281 (1.4); 7.2236 (5.9); 7.2183 (1.3); 7.2067 (1.1); 7.2009 (3.7); 5.7539 (16.0); 4.9410 (0.5); 4.2389 (1.7); 4.2219 (1.9); 4.2131 (2.2); 4.1962 (1.7); 4.0561 (0.7); 4.0382 (2.1); 4.0204 (2.2); 4.0026 (0.7); 3.7667 (1.1); 3.7586 (1.1); 3.7408 (1.0); 3.7333 (1.0); 3.3122 (36.2); 3.0340 (1.6); 3.0135 (1.8); 2.9910 (2.1); 2.9706 (1.8); 2.6698 (0.6); 2.5532 (0.9); 2.5440 (1.0); 2.5233 (1.7); 2.5186 (2.6); 2.5099 (32.0); 2.5054 (68.2); 2.5007 (94.9); 2.4961 (65.7); 2.4916 (29.2); 2.3275 (0.6); 1.9881 (10.4); 1.2965 (0.6); 1.2791 (1.5); 1.2667 (1.8); 1.2581 (2.5); 1.2475 (7.1); 1.1924 (3.0); 1.1746 (6.0); 1.1568 (2.9); 0.8752 (3.6); 0.8583 (14.1); 0.8407 (4.8); -0.0002 (13.6) I.5-9: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 9.1522 (2.7); 8.3087 (0.6); 7.5024 (0.5); 7.4907 (2.6); 7.4850 (3.0); 7.4653 (3.1); 7.4597 (2.5); 7.4113 (2.1); 7.4069 (2.2); 7.2714 (2.0); 7.2506 (3.8); 7.2134 (2.8); 7.2079 (2.5); 7.1929 (1.4); 7.1874 (1.3); 7.0382 (0.5); 7.0325 (0.8); 7.0152 (1.0); 7.0095 (1.6); 7.0037 (0.9); 6.9921 (0.6); 6.9863 (0.8); 4.2207 (1.4); 4.2031 (1.6); 4.1945 (1.8); 4.1770 (1.5); 3.7728 (1.1); 3.7641 (1.1); 3.7465 (1.0); 3.7382 (1.0); 3.3102 (45.2); 3.3091 (44.5); 3.0703 (1.5); 3.0492 (1.7); 3.0268 (2.0); 3.0058 (1.7); 2.6742 (0.6); 2.6694 (0.8); 2.6648 (0.6); 2.5986 (1.0); 2.5884 (1.0); 2.5556 (0.9); 2.5441 (0.8); 2.5229 (2.9); 2.5182 (4.1); 2.5096 (50.3); 2.5050 (108.1); 2.5004 (150.2); 2.4958 (104.8); 2.4912 (46.7); 2.3318 (0.6); 2.3272 (0.9); 2.3226 (0.6); 2.1440 (16.0); -0.0002 (6.5) I.5-11: 1 H-NMR (400.0 MHz, CDCl3): δ= 7.6625 (6.0); 7.6076 (4.2); 7.5716 (2.4); 7.5487 (2.3); 7.5381 (2.0); 7.5180 (16.0); 7.4941 (15.0); 7.4346 (2.4); 7.4098 (5.9); 7.3897 (6.6); 7.3683 (4.3); 7.3627 (3.6); 7.3459 (4.0); 7.3192 (15.9); 7.2968 (13.7); 7.2903 (5.5); 7.2832 (4.2); 7.2801 (4.6); 7.2793 (4.4); 7.2784 (4.6); 7.2769 (4.4); 7.2761 (4.7); 7.2753 (5.0); 7.2745 (5.3); 7.2737 (5.5); 7.2729 (5.9); 7.2720 (6.5); 7.2713 (7.2); 7.2704 (7.9); 7.2680 (14.4); 7.2593 (1102.6); 7.2495 (11.3); 7.2487 (11.0); 7.2479 (10.4); 7.2471 (9.8); 7.2463 (9.7); 7.2455 (9.5); 7.2439 (9.3); 7.2335 (10.7); 7.2257 (10.4); 7.2093 (16.7); 7.1171 (1.4); 7.0607 (1.0); 6.9953 (6.8); 6.4725 (2.2); 5.1541 (2.4); 4.2952 (2.9); 4.2799 (3.3); 4.2674 (3.8); 4.2523 (3.7); 4.1625 (0.8); 4.1470 (1.1); 4.1367 (1.1); 4.1296 (1.8); 4.1119 (1.7); 3.9511 (3.9); 3.9243 (3.9); 3.1435 (3.2); 3.1230 (3.2); 3.0993 (3.9); 3.0784 (3.9); 2.9881 (0.8); 2.9694 (0.9); 2.5423 (2.9); 2.4923 (2.5); 2.0427 (6.9); 2.0037 (0.9); 1.5534 (46.1); 1.2758 (3.4); 1.2579 (6.1); 1.2400 (2.7); 0.8989 (1.6); 0.8820 (5.0); 0.8644 (2.0); 0.4368 (1.2); 0.3305 (1.0); 0.2373 (1.6); 0.1568 (2.7); 0.1464 (1.6); 0.1263 (0.9); 0.0501 (1.8); 0.0080 (15.0); -0.0002 (436.7); -0.0085 (16.3); -0.0499 (5.4); -0.1494 (1.8) I.5-12: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 9.1137 (2.2); 8.3451 (0.6); 7.6662 (3.8); 7.6633 (4.7); 7.6442 (5.2); 7.6416 (4.4); 7.4426 (1.7); 7.4005 (3.6); 7.3954 (1.3); 7.3820 (4.6); 7.3791 (3.7); 7.3604 (3.7); 7.2651 (1.9); 7.2444 (3.4); 7.2046 (2.4); 7.1989 (2.2); 7.1841 (1.3); 7.1785 (1.2); 7.1612 (1.9); 7.1585 (1.1); 7.1427 (3.1); 7.1243 (1.4); 5.7538 (0.8); 4.9559 (0.5); 4.2378 (1.6); 4.2208 (1.8); 4.2121 (2.0); 4.1951 (1.6); 3.7789 (1.2); 3.7701 (1.1); 3.7525 (1.1); 3.7442 (1.0); 3.3107 (103.6); 3.0234 (1.6); 3.0029 (1.8); 2.9805 (2.0); 2.9600 (1.8); 2.6740 (1.2); 2.6694 (1.7); 2.6648 (1.2); 2.5695 (1.1); 2.5604 (1.0); 2.5229 (5.2); 2.5181 (7.4); 2.5095 (96.8); 2.5049 (212.2); 2.5003 (297.5); 2.4957 (208.0); 2.4911 (93.4); 2.3317 (1.2); 2.3271 (1.7); 2.3225 (1.3); 2.1432 (16.0); 1.9878 (1.5); 1.1743 (0.8); 0.0079 (1.2); -0.0002 (43.5); -0.0086 (1.4) I.5-13: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 9.2085 (4.3); 8.6230 (1.5); 7.7032 (1.7); 7.6669 (8.9); 7.6640 (11.9); 7.6622 (11.5); 7.6554 (7.5); 7.6450 (11.3); 7.6424 (9.4); 7.4151 (5.1); 7.4089 (5.6); 7.4034 (8.6); 7.3981 (2.9); 7.3934 (5.0); 7.3850 (11.0); 7.3633 (8.1); 7.1642 (4.1); 7.1458 (6.6); 7.1274 (3.0); 5.7538 (16.0); 4.9260 (1.2); 4.2481 (3.3); 4.2313 (3.7); 4.2220 (4.2); 4.2055 (3.5); 3.7765 (2.2); 3.7581 (2.1); 3.7501 (2.1); 3.3114 (268.8); 3.3101 (264.4); 3.2586 (1.0); 3.0436 (2.9); 3.0233 (3.2); 3.0006 (3.8); 2.9801 (3.4); 2.6742 (3.2); 2.6695 (4.4); 2.6648 (3.3); 2.5630 (2.1); 2.5229 (12.3); 2.5182 (18.3); 2.5095 (265.4); 2.5049 (583.8); 2.5003 (820.6); 2.4957 (575.5); 2.4911 (260.0); 2.4495 (2.6); 2.3318 (3.3); 2.3271 (4.9); 2.3226 (3.5); 1.2494 (0.9); 0.8583 (1.3); 0.0080 (3.0); -0.0002 (114.0); -0.0085 (3.5) I.5-14: 1 H-NMR (400.0 MHz, CDCl3): δ= 7.5220 (10.8); 7.5175 (15.6); 7.5030 (5.7); 7.4816 (7.0); 7.3587 (3.2); 7.3410 (8.3); 7.3356 (6.6); 7.3200 (7.7); 7.2591 (1451.9); 7.1844 (3.5); 7.1653 (7.7); 7.1452 (3.5); 6.9951 (8.2); 6.3306 (2.3); 4.2424 (2.9); 4.2272 (2.9); 4.2153 (3.5); 4.2006 (3.0); 4.1304 (3.1); 4.1123 (3.9); 3.8812 (3.4); 3.8526 (2.9); 3.0851 (3.2); 3.0657 (3.5); 3.0403 (3.7); 3.0220 (3.5); 2.5152 (2.9); 2.4643 (2.8); 2.0434 (16.0); 1.5284 (77.9); 1.2764 (5.9); 1.2586 (10.0); 1.2406 (4.6); 0.8821 (4.9); 0.0080 (23.0); -0.0002 (598.4); -0.0085 (19.7) I.5-15: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 9.2028 (2.2); 8.5827 (0.9); 8.5660 (0.9); 7.9203 (0.6); 7.5360 (3.9); 7.5144 (4.6); 7.3008 (1.2); 7.2945 (1.2); 7.2792 (1.0); 7.2729 (1.0); 5.7519 (0.8); 4.1900 (1.1); 4.1730 (1.5); 4.1560 (1.1); 3.6776 (1.1); 3.6607 (1.2); 3.6519 (1.3); 3.6351 (1.2); 3.3063 (39.3); 3.2269 (1.0); 3.2180 (1.0); 3.2013 (0.9); 3.1924 (0.9); 2.7346 (1.3); 2.7140 (1.4); 2.6925 (1.7); 2.6718 (1.6); 2.5228 (1.1); 2.5181 (1.5); 2.5095 (21.8); 2.5049 (47.6); 2.5003 (66.8); 2.4957 (46.9); 2.4911 (21.4); 2.2794 (0.5); 2.2699 (0.5); 1.0861 (8.6); 1.0695 (16.0); 1.0530 (8.5); -0.0002 (2.1) I.5-16: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 9.2522 (3.0); 8.8288 (1.7); 8.8118 (1.7); 7.9403 (0.8); 7.5499 (5.8); 7.5451 (1.9); 7.5349 (6.4); 7.5286 (6.8); 7.5134 (6.2); 7.3008 (1.4); 7.2948 (1.4); 7.2795 (1.2); 7.2732 (1.1); 7.1991 (4.8); 7.1786 (4.4); 5.7574 (0.6); 4.9022 (0.6); 4.2285 (1.6); 4.2120 (1.9); 4.2024 (2.1); 4.1860 (1.7); 3.7603 (1.1); 3.7406 (1.0); 3.4059 (132.8); 3.3562 (2.0); 3.1222 (0.6); 3.1100 (0.6); 3.1038 (1.9); 3.0918 (1.9); 3.0856 (2.0); 3.0736 (1.9); 3.0675 (0.6); 3.0554 (0.6); 3.0438 (1.5); 3.0236 (1.6); 3.0009 (1.9); 2.9807 (1.6); 2.6754 (0.8); 2.6709 (1.2); 2.6664 (0.9); 2.5244 (3.6); 2.5197 (4.7); 2.5110 (54.4); 2.5064 (119.3); 2.5018 (166.6); 2.4972 (116.8); 2.4926 (51.7); 2.4566 (1.5); 2.4519 (1.9); 2.4474 (1.3); 2.3332 (0.9); 2.3286 (1.3); 2.3239 (0.9); 2.2813 (16.0); 2.0744 (0.6); 1.1987 (3.6); 1.1805 (7.6); 1.1622 (3.5); -0.0002 (0.9) I.5-17: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 9.1984 (4.4); 8.6297 (1.7); 8.6137 (1.7); 7.9274 (0.8); 7.5352 (6.9); 7.5136 (8.1); 7.3007 (1.7); 7.2945 (1.7); 7.2790 (1.4); 7.2727 (1.4); 5.7537 (3.2); 4.7744 (0.7); 4.0380 (0.8); 4.0202 (0.8); 3.7237 (2.1); 3.7069 (2.3); 3.6977 (2.6); 3.6810 (2.2); 3.3103 (117.3); 3.2980 (2.1); 3.2806 (1.5); 3.2720 (1.5); 3.2602 (1.0); 3.0166 (2.8); 3.0064 (2.9); 2.9980 (3.2); 2.9878 (2.9); 2.9733 (0.5); 2.7735 (1.5); 2.7530 (1.7); 2.7313 (2.0); 2.7108 (1.8); 2.6740 (0.8); 2.6695 (1.2); 2.6649 (0.8); 2.5230 (2.7); 2.5183 (3.9); 2.5096 (60.5); 2.5050 (134.8); 2.5003 (190.2); 2.4957 (131.7); 2.4911 (58.0); 2.4550 (1.4); 2.4504 (1.7); 2.4458 (1.1); 2.3318 (0.9); 2.3272 (1.2); 2.3225 (0.9); 2.2985 (0.8); 2.2483 (0.7); 1.9878 (3.8); 1.8830 (0.6); 1.8648 (1.2); 1.8479 (1.6); 1.8313 (1.3); 1.8139 (0.6); 1.1922 (1.1); 1.1745 (2.3); 1.1567 (1.2); 0.8583 (0.8); 0.8450 (15.0); 0.8344 (16.0); 0.8284 (15.5); 0.8178 (14.9); 0.0079 (3.6); 0.0063 (0.8); 0.0054 (1.0); 0.0046 (1.2); 0.0037 (1.7); 0.0021 (5.2); -0.0002 (132.1); -0.0028 (5.9); -0.0044 (2.0); -0.0052 (1.5); - 0.0061 (1.2); -0.0069 (1.1); -0.0085 (3.8); -0.0108 (0.6); -0.0116 (0.5); -0.0503 (0.9) I.5-18: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 9.2304 (1.6); 8.7993 (0.8); 8.7828 (0.8); 7.5665 (3.0); 7.5608 (1.0); 7.5492 (1.2); 7.5436 (3.4); 7.5357 (2.3); 7.5142 (2.5); 7.3011 (0.7); 7.2953 (0.7); 7.2797 (0.6); 7.2733 (0.6); 6.9614 (3.3); 6.9558 (1.0); 6.9385 (3.0); 4.2184 (0.7); 4.2018 (0.8); 4.1924 (1.0); 4.1759 (0.8); 3.7437 (16.0); 3.7220 (0.6); 3.3168 (106.8); 3.2668 (0.9); 3.0996 (0.5); 3.0940 (0.5); 3.0817 (0.5); 3.0241 (0.7); 3.0038 (0.7); 2.9811 (0.8); 2.9615 (0.7); 2.6745 (0.6); 2.6696 (0.7); 2.6652 (0.6); 2.5232 (3.6); 2.5097 (44.3); 2.5052 (90.4); 2.5007 (122.9); 2.4961 (87.1); 2.4916 (40.2); 2.4553 (1.1); 2.4507 (1.4); 2.4461 (1.1); 2.3276 (0.8); 1.1947 (1.2); 1.1765 (2.3); 1.1583 (1.1); 0.0080 (1.7); -0.0002 (58.1); -0.0085 (2.3); -0.0501 (0.5) I.5-19: 1H-NMR (400.0 MHz, d6-DMSO): δ= 9.2094 (10.0); 8.6074 (3.8); 8.5906 (3.7); 7.9225 (1.9); 7.7580 (2.2); 7.7517 (2.3); 7.6757 (2.3); 7.6539 (2.9); 7.5590 (0.6); 7.5362 (13.5); 7.5147 (16.0); 7.4912 (2.1); 7.4850 (2.0); 7.4694 (1.6); 7.4632 (1.6); 7.3013 (3.9); 7.2950 (3.8); 7.2798 (3.2); 7.2734 (3.1); 5.7529 (1.5); 4.7815 (1.4); 4.3877 (0.6); 4.3687 (2.4); 4.3495 (3.5); 4.3296 (2.1); 4.3101 (0.6); 3.7125 (3.8); 3.6956 (4.2); 3.6867 (4.7); 3.6699 (4.0); 3.3510 (0.8); 3.3169 (349.3); 3.2666 (2.8); 3.2566 (3.4); 3.2482 (3.4); 3.2310 (2.9); 3.2226 (3.2); 3.1985 (0.6); 3.1123 (0.7); 3.1007 (0.8); 3.0943 (0.7); 3.0824 (0.8); 2.7464 (4.1); 2.7258 (4.6); 2.7042 (5.4); 2.6836 (4.8); 2.6751 (0.9); 2.6704 (0.9); 2.6657 (0.7); 2.5238 (2.5); 2.5191 (3.7); 2.5105 (45.5); 2.5059 (98.1); 2.5013 (137.1); 2.4967 (97.4); 2.4921 (45.3); 2.4559 (1.0); 2.4512 (1.2); 2.4468 (1.0); 2.4057 (0.5); 2.3326 (0.7); 2.3280 (1.0); 2.3234 (0.7); 2.2739 (1.8); 2.2314 (1.6); 1.7437 (1.3); 1.7205 (2.6); 1.7082 (3.3); 1.6898 (3.1); 1.6717 (2.5); 1.6567 (3.6); 1.6500 (3.8); 1.6434 (4.6); 1.6305 (3.1); 1.6088 (1.3); 1.5493 (3.2); 1.5428 (3.8); 1.5314 (6.0); 1.5154 (7.5); 1.4944 (3.7); 1.4755 (2.3); 1.1961 (2.0); 1.1779 (4.0); 1.1597 (1.9); -0.0002 (1.1) I.5-20: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 9.2442 (4.1); 8.7625 (1.9); 8.7464 (1.9); 7.9027 (6.0); 7.8968 (3.2); 7.8857 (3.6); 7.8798 (16.0); 7.8606 (15.8); 7.8546 (2.8); 7.8433 (1.9); 7.8377 (4.4); 7.5340 (7.6); 7.5123 (9.1); 7.3059 (2.6); 7.2996 (2.5); 7.2848 (2.1); 7.2781 (2.1); 5.7512 (6.7); 4.9566 (0.9); 4.2936 (2.2); 4.2769 (2.6); 4.2674 (2.8); 4.2508 (2.2); 4.0563 (0.6); 4.0384 (1.6); 4.0205 (1.6); 4.0027 (0.5); 3.8516 (1.8); 3.8443 (1.8); 3.8261 (1.6); 3.8185 (1.6); 3.3561 (0.6); 3.3375 (0.8); 3.3023 (299.6); 3.2732 (1.0); 3.1225 (2.3); 3.1023 (2.5); 3.0791 (2.8); 3.0588 (2.4); 2.6736 (2.6); 2.6689 (3.7); 2.6643 (2.7); 2.6597 (1.3); 2.6106 (1.6); 2.5659 (1.2); 2.5329 (2.2); 2.5225 (11.2); 2.5177 (16.2); 2.5091 (211.3); 2.5045 (452.6); 2.4999 (627.8); 2.4953 (436.1); 2.4907 (195.0); 2.4686 (1.7); 2.4639 (1.2); 2.4593 (0.8); 2.3313 (2.7); 2.3267 (3.7); 2.3220 (2.6); 2.0713 (0.5); 1.9873 (7.7); 1.1924 (2.0); 1.1746 (4.1); 1.1568 (2.0); -0.0002 (15.7) I.5-22: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 9.2370 (5.5); 8.5857 (1.4); 7.8976 (4.5); 7.8917 (2.1); 7.8806 (3.3); 7.8747 (16.0); 7.8562 (15.9); 7.8504 (3.2); 7.8389 (1.9); 7.8334 (4.4); 7.6934 (1.5); 7.6628 (7.8); 7.6568 (7.7); 7.4178 (4.5); 7.4117 (4.2); 7.3962 (3.8); 7.3902 (3.8); 4.9713 (1.0); 4.2826 (2.2); 4.2655 (2.7); 4.2566 (3.0); 4.2395 (2.3); 4.0558 (0.7); 4.0382 (2.4); 4.0204 (2.5); 4.0027 (0.8); 3.8291 (1.7); 3.8215 (1.9); 3.8033 (1.7); 3.3050 (249.4); 3.2566 (0.7); 3.1025 (2.3); 3.0818 (2.7); 3.0589 (3.0); 3.0384 (2.7); 2.6738 (2.2); 2.6691 (3.2); 2.6646 (2.3); 2.6135 (1.6); 2.6033 (1.6); 2.5603 (1.9); 2.5225 (9.7); 2.5178 (14.7); 2.5092 (180.8); 2.5046 (386.7); 2.5000 (533.6); 2.4955 (379.6); 2.4909 (174.7); 2.4468 (0.8); 2.3314 (2.3); 2.3267 (3.2); 2.3222 (2.3); 2.0718 (0.7); 1.9875 (11.1); 1.2485 (1.1); 1.1923 (3.2); 1.1745 (6.6); 1.1567 (3.1); 0.8750 (0.5); 0.8584 (1.7); 0.8411 (0.6); -0.0002 (15.5) I.5-23: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 9.1369 (16.0); 8.3689 (4.4); 8.3520 (4.4); 7.6901 (2.8); 7.6716 (3.0); 7.6550 (3.3); 7.6507 (2.6); 7.6472 (2.4); 7.6386 (2.3); 7.6371 (2.5); 7.6316 (2.9); 7.5820 (0.5); 7.5703 (2.5); 7.5648 (2.2); 7.5633 (1.9); 7.5547 (2.1); 7.5512 (2.2); 7.5465 (3.0); 7.5359 (0.5); 7.5005 (11.9); 7.4968 (12.1); 7.4806 (14.4); 7.4769 (14.4); 7.4465 (1.1); 7.4414 (1.6); 7.4374 (0.9); 7.4277 (4.4); 7.4227 (4.8); 7.4190 (4.4); 7.4113 (8.1); 7.4038 (3.3); 7.4003 (4.1); 7.3951 (3.2); 7.3815 (1.2); 7.3763 (0.8); 7.3395 (5.7); 7.3357 (6.1); 7.3208 (10.5); 7.3170 (10.0); 7.3011 (8.3); 7.2972 (7.6); 7.2482 (6.0); 7.2441 (6.1); 7.2287 (7.8); 7.2249 (7.7); 7.2097 (3.7); 7.2057 (3.5); 5.7526 (3.2); 4.7941 (2.2); 4.5737 (1.2); 4.5560 (1.2); 4.3870 (1.0); 4.3677 (4.1); 4.3486 (6.1); 4.3287 (3.5); 4.3092 (1.0); 4.1252 (0.6); 4.1075 (0.6); 3.7028 (6.3); 3.6856 (7.1); 3.6773 (7.9); 3.6602 (6.8); 3.3460 (0.6); 3.3171 (495.1); 3.2939 (1.2); 3.2853 (1.3); 3.2811 (0.7); 3.2669 (3.7); 3.2505 (5.6); 3.2412 (5.7); 3.2263 (5.5); 3.2161 (5.3); 3.1980 (1.0); 2.7249 (8.3); 2.7042 (9.3); 2.6828 (11.0); 2.6748 (1.2); 2.6700 (1.5); 2.6621 (9.8); 2.5235 (2.8); 2.5188 (4.0); 2.5102 (60.0); 2.5056 (132.8); 2.5009 (187.4); 2.4963 (130.3); 2.4917 (57.7); 2.4554 (1.4); 2.4508 (1.6); 2.4462 (1.3); 2.4417 (0.8); 2.4104 (0.6); 2.4058 (0.6); 2.3368 (0.5); 2.3324 (1.0); 2.3277 (1.4); 2.3232 (1.0); 2.2900 (3.1); 2.2803 (3.2); 2.2484 (2.6); 2.2379 (2.6); 1.7391 (2.1); 1.7276 (3.3); 1.7199 (4.4); 1.7052 (5.4); 1.6978 (5.0); 1.6881 (4.8); 1.6825 (4.9); 1.6694 (4.2); 1.6551 (5.9); 1.6487 (6.2); 1.6424 (7.4); 1.6273 (5.0); 1.6072 (2.0); 1.5699 (2.1); 1.5477 (5.0); 1.5386 (6.0); 1.5300 (9.3); 1.5167 (11.5); 1.5128 (12.3); 1.4926 (5.5); 1.4734 (3.5); 1.3402 (1.4); 1.3225 (3.0); 1.3048 (1.4); 1.2509 (0.7); 1.2331 (1.6); 1.2154 (0.7); 1.1943 (0.7); 1.1761 (1.3); 1.1578 (0.8); 1.1544 (1.6); 1.1367 (3.2); 1.1190 (1.4); -0.0002 (1.8) I.5-24: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 9.3900 (4.8); 9.3774 (1.9); 8.5873 (1.1); 8.0105 (0.6); 7.8894 (2.9); 7.8832 (3.2); 7.5575 (8.0); 7.5359 (10.0); 7.5301 (5.0); 7.5146 (1.6); 7.5085 (6.6); 7.5031 (4.0); 7.4973 (4.7); 7.4778 (4.3); 7.4721 (3.4); 7.3331 (2.4); 7.3268 (2.4); 7.3116 (2.2); 7.3053 (2.2); 7.3019 (2.6); 7.2954 (2.3); 7.2803 (2.2); 7.2738 (1.9); 7.0451 (0.9); 7.0394 (1.5); 7.0220 (1.8); 7.0163 (2.9); 7.0105 (1.4); 6.9932 (1.5); 4.7183 (0.7); 4.2475 (2.0); 4.2287 (2.2); 4.2224 (2.3); 4.2036 (1.9); 4.0558 (0.6); 4.0381 (1.8); 4.0203 (1.9); 4.0025 (0.7); 3.6492 (2.2); 3.6332 (2.2); 3.6240 (2.0); 3.6083 (1.9); 3.3608 (0.6); 3.3104 (278.1); 3.2603 (1.9); 2.8269 (0.9); 2.8103 (1.3); 2.7918 (0.9); 2.6742 (1.9); 2.6696 (2.6); 2.6648 (1.8); 2.5510 (0.6); 2.5230 (6.8); 2.5184 (9.3); 2.5097 (138.6); 2.5051 (308.8); 2.5004 (435.4); 2.4958 (303.0); 2.4912 (134.8); 2.4664 (1.4); 2.4596 (1.9); 2.4551 (2.7); 2.4505 (3.3); 2.4457 (2.5); 2.4004 (0.8); 2.3319 (2.0); 2.3273 (2.7); 2.3225 (2.0); 1.9879 (8.9); 1.2524 (16.0); 1.2344 (15.7); 1.1961 (1.2); 1.1923 (3.1); 1.1745 (5.5); 1.1567 (2.7); 1.1432 (1.7); 1.1246 (1.8); 0.8752 (0.9); 0.8584 (4.0); 0.8407 (1.4); 0.1458 (0.7); 0.0080 (6.4); 0.0055 (1.3); 0.0047 (1.6); -0.0002 (240.1); -0.0051 (3.8); -0.0059 (3.2); -0.0068 (2.8); -0.0085 (7.4); -0.0503 (1.7); -0.1495 (0.8) I.5-25: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 9.1671 (3.1); 8.5717 (1.1); 8.5560 (1.1); 7.7082 (0.7); 7.6890 (0.7); 7.5567 (0.6); 7.5532 (1.1); 7.5470 (5.8); 7.5423 (1.8); 7.5304 (2.0); 7.5257 (6.5); 7.5194 (0.8); 7.4982 (2.6); 7.4946 (2.6); 7.4783 (3.1); 7.4746 (3.0); 7.4284 (0.7); 7.4233 (0.7); 7.4197 (0.7); 7.4121 (1.2); 7.4010 (0.6); 7.3390 (1.2); 7.3352 (1.2); 7.3202 (2.2); 7.3165 (2.1); 7.3005 (1.7); 7.2967 (1.6); 7.2461 (1.3); 7.2420 (1.3); 7.2265 (1.7); 7.2228 (1.7); 7.2075 (1.0); 7.2036 (1.3); 7.1958 (4.8); 7.1754 (4.3); 5.7553 (0.5); 4.9352 (0.5); 4.2175 (1.6); 4.2006 (1.9); 4.1916 (2.1); 4.1748 (1.7); 3.7571 (1.1); 3.7491 (1.1); 3.7314 (1.0); 3.7236 (1.0); 3.3676 (0.6); 3.3175 (134.2); 3.2672 (0.9); 3.0224 (1.6); 3.0019 (1.8); 2.9795 (2.1); 2.9591 (1.8); 2.6698 (0.6); 2.5460 (1.1); 2.5365 (0.9); 2.5233 (1.7); 2.5186 (2.4); 2.5099 (36.2); 2.5053 (80.0); 2.5007 (112.5); 2.4961 (78.5); 2.4915 (35.0); 2.4552 (0.7); 2.4506 (1.0); 2.4459 (0.7); 2.3321 (0.6); 2.3275 (0.7); 2.3228 (0.5); 2.2802 (16.0); 1.9882 (1.0); 1.1921 (0.9); 1.1743 (1.7); 1.1564 (0.8); 1.1359 (0.5); 0.0080 (1.8); 0.0046 (0.6); -0.0002 (72.0); -0.0052 (1.2); -0.0060 (0.9); -0.0069 (0.8); -0.0085 (2.2); -0.0503 (0.6) I.5-26: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 9.1835 (4.9); 8.5556 (1.5); 8.5392 (1.5); 7.7276 (1.2); 7.7196 (11.4); 7.7141 (3.6); 7.7024 (4.3); 7.6968 (14.8); 7.6888 (2.3); 7.6769 (1.2); 7.6550 (0.8); 7.6508 (0.7); 7.6472 (0.7); 7.6387 (0.6); 7.6371 (0.6); 7.6312 (0.7); 7.5701 (0.6); 7.5547 (0.5); 7.5511 (0.6); 7.5467 (0.7); 7.5461 (0.7); 7.5005 (4.0); 7.4968 (4.1); 7.4806 (4.9); 7.4769 (4.8); 7.4584 (1.4); 7.4503 (14.3); 7.4448 (3.9); 7.4413 (0.9); 7.4395 (0.8); 7.4331 (3.5); 7.4276 (13.4); 7.4225 (1.6); 7.4190 (1.7); 7.4112 (1.9); 7.4036 (0.8); 7.4002 (1.1); 7.3949 (0.8); 7.3421 (1.9); 7.3383 (2.0); 7.3234 (3.6); 7.3196 (3.4); 7.3037 (2.8); 7.2998 (2.6); 7.2505 (2.1); 7.2465 (2.2); 7.2310 (2.7); 7.2272 (2.7); 7.2121 (1.3); 7.2081 (1.2); 5.7551 (12.8); 4.9594 (0.8); 4.2406 (2.5); 4.2236 (2.9); 4.2147 (3.2); 4.1978 (2.6); 4.0561 (1.1); 4.0382 (3.4); 4.0204 (3.4); 4.0026 (1.1); 3.7806 (1.8); 3.7725 (1.8); 3.7548 (1.6); 3.7467 (1.6); 3.3222 (83.2); 3.2723 (0.7); 3.0531 (2.6); 3.0326 (2.9); 3.0100 (3.3); 2.9895 (2.9); 2.5752 (1.4); 2.5653 (1.4); 2.5319 (1.3); 2.5239 (1.8); 2.5195 (1.9); 2.5107 (15.5); 2.5061 (34.2); 2.5015 (48.1); 2.4968 (33.6); 2.4923 (14.9); 1.9887 (16.0); 1.3235 (0.8); 1.1925 (4.8); 1.1747 (9.4); 1.1569 (4.7); 1.1368 (0.9); -0.0002 (4.6) I.5-27: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 9.1289 (4.4); 8.4001 (1.4); 8.3830 (1.4); 7.6788 (0.9); 7.4988 (3.1); 7.4951 (3.2); 7.4789 (3.7); 7.4752 (3.7); 7.3385 (1.5); 7.3348 (1.6); 7.3197 (2.9); 7.3160 (2.8); 7.3001 (2.1); 7.2963 (1.9); 7.2461 (1.6); 7.2421 (1.7); 7.2266 (2.2); 7.2230 (2.2); 7.2076 (1.0); 7.2038 (1.0); 5.7534 (3.5); 4.7886 (0.8); 3.7134 (2.0); 3.6964 (2.2); 3.6877 (2.5); 3.6707 (2.2); 3.3122 (146.8); 3.2927 (2.7); 3.2757 (1.9); 3.2666 (1.7); 3.2615 (1.6); 3.0494 (0.7); 3.0307 (0.8); 3.0161 (3.0); 2.9979 (5.4); 2.9801 (2.9); 2.9652 (0.8); 2.9468 (0.7); 2.7508 (1.7); 2.7300 (1.9); 2.7086 (2.3); 2.6879 (2.1); 2.6741 (0.6); 2.6696 (0.8); 2.6646 (0.5); 2.5229 (2.4); 2.5182 (3.5); 2.5096 (41.6); 2.5050 (89.9); 2.5004 (125.6); 2.4959 (90.5); 2.4913 (43.4); 2.4590 (0.8); 2.4544 (1.1); 2.4499 (1.3); 2.4453 (1.0); 2.3319 (0.7); 2.3273 (0.9); 2.3224 (0.7); 2.3089 (1.0); 2.2999 (1.0); 2.2651 (0.8); 2.2564 (0.8); 1.8798 (0.7); 1.8621 (1.3); 1.8453 (1.8); 1.8284 (1.4); 1.8113 (0.7); 0.8430 (15.0); 0.8345 (16.0); 0.8264 (15.6); 0.8179 (15.3); 0.0080 (0.6); -0.0002 (21.1); - 0.0085 (0.8) I.5-28: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 9.0832 (2.5); 8.1155 (0.6); 7.4065 (1.5); 7.2678 (1.8); 7.2471 (3.4); 7.2077 (2.4); 7.2022 (2.3); 7.1870 (1.1); 7.1819 (1.2); 4.1997 (0.5); 4.1824 (1.4); 4.1655 (1.9); 4.1487 (1.4); 3.6560 (1.2); 3.6384 (1.3); 3.6304 (1.4); 3.6130 (1.3); 3.3365 (1.0); 3.3047 (224.7); 3.2026 (1.4); 3.1928 (1.6); 3.1775 (1.3); 3.1674 (1.2); 2.6863 (1.6); 2.6737 (1.7); 2.6690 (2.5); 2.6649 (3.0); 2.6443 (2.0); 2.6233 (1.6); 2.5225 (6.6); 2.5178 (9.0); 2.5092 (128.3); 2.5046 (280.3); 2.5000 (393.6); 2.4953 (276.4); 2.4908 (125.8); 2.4495 (0.6); 2.3866 (0.6); 2.3360 (0.8); 2.3314 (1.8); 2.3267 (2.4); 2.3222 (1.7); 2.2962 (1.0); 2.2840 (0.9); 2.2539 (1.0); 2.2423 (0.8); 2.1401 (16.0); 1.0737 (10.5); 1.0650 (11.0); 1.0568 (10.8); 1.0481 (11.0); - 0.0002 (1.5) I.5-29: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 9.1654 (1.2); 7.5638 (2.8); 7.5581 (0.9); 7.5466 (0.9); 7.5408 (3.1); 7.5004 (1.0); 7.4966 (1.0); 7.4804 (1.2); 7.4767 (1.2); 7.3218 (0.8); 7.3180 (0.8); 7.3021 (0.7); 7.2982 (0.6); 7.2475 (0.5); 7.2434 (0.5); 7.2276 (0.7); 6.9592 (3.1); 6.9535 (0.9); 6.9420 (0.9); 6.9363 (2.8); 4.2074 (0.6); 4.1905 (0.8); 4.1815 (0.8); 4.1648 (0.7); 3.7431 (16.0); 3.3666 (0.5); 3.3166 (111.2); 3.2665 (1.1); 3.0034 (0.6); 2.9829 (0.7); 2.9604 (0.8); 2.9401 (0.7); 2.6698 (0.7); 2.5232 (4.2); 2.5186 (5.6); 2.5099 (37.4); 2.5053 (77.6); 2.5007 (106.7); 2.4961 (74.8); 2.4915 (33.5); 2.4600 (0.7); 2.4552 (1.0); 2.4506 (1.3); 2.4460 (0.9); 2.3275 (0.7); 1.1756 (0.8); 0.0080 (2.2); 0.0064 (0.8); 0.0056 (0.8); 0.0048 (0.9); 0.0039 (1.1); -0.0002 (65.4); -0.0058 (1.3); -0.0067 (1.1); -0.0085 (2.2); -0.0503 (0.7) I.5-31: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 9.1527 (16.0); 8.3945 (4.1); 8.3779 (4.0); 7.6905 (2.7); 7.6739 (2.9); 7.6563 (2.1); 7.6520 (1.6); 7.6485 (1.4); 7.6399 (1.2); 7.6384 (1.3); 7.6326 (1.5); 7.5892 (0.6); 7.5828 (0.6); 7.5798 (0.6); 7.5771 (0.7); 7.5715 (1.6); 7.5660 (1.5); 7.5561 (1.1); 7.5526 (1.2); 7.5478 (1.5); 7.5371 (0.6); 7.5180 (0.5); 7.5018 (11.4); 7.4981 (11.8); 7.4819 (13.8); 7.4781 (13.9); 7.4617 (0.6); 7.4551 (0.7); 7.4495 (0.9); 7.4468 (0.8); 7.4418 (0.8); 7.4376 (1.4); 7.4280 (2.3); 7.4231 (3.0); 7.4195 (2.4); 7.4118 (4.0); 7.4069 (0.7); 7.4042 (1.6); 7.4008 (2.4); 7.3956 (1.4); 7.3820 (0.6); 7.3769 (0.5); 7.3414 (5.5); 7.3376 (5.9); 7.3226 (10.1); 7.3188 (9.6); 7.3030 (7.9); 7.2991 (7.3); 7.2495 (5.7); 7.2455 (5.8); 7.2300 (7.4); 7.2262 (7.4); 7.2111 (3.5); 7.2071 (3.3); 4.8127 (2.1); 4.5910 (0.7); 4.5733 (2.3); 4.5556 (2.4); 4.5434 (1.3); 4.5380 (0.9); 4.5204 (3.4); 4.5002 (6.5); 4.4799 (3.6); 4.4765 (3.7); 4.4563 (1.8); 4.1662 (0.5); 4.1247 (0.6); 4.1070 (0.6); 3.8105 (6.0); 3.7932 (6.6); 3.7850 (7.5); 3.7677 (6.5); 3.3716 (5.7); 3.3614 (5.7); 3.3452 (5.2); 3.3359 (5.5); 3.3222 (407.6); 3.2903 (0.7); 3.2879 (0.8); 3.2724 (3.7); 3.2226 (0.6); 3.1752 (2.1); 3.1622 (2.1); 3.1105 (0.6); 3.0983 (0.7); 3.0809 (0.6); 2.7356 (7.9); 2.7147 (8.8); 2.6933 (10.4); 2.6724 (9.6); 2.5237 (1.4); 2.5190 (2.0); 2.5102 (50.6); 2.5057 (116.5); 2.5010 (166.9); 2.4964 (118.3); 2.4918 (54.0); 2.4560 (1.7); 2.4512 (2.0); 2.4468 (1.6); 2.4062 (0.6); 2.3324 (1.0); 2.3279 (1.3); 2.3232 (1.0); 2.3186 (0.7); 2.2975 (3.2); 2.2870 (3.2); 2.2553 (2.6); 2.2449 (2.7); 2.2166 (1.6); 2.1915 (5.4); 2.1667 (9.5); 2.1634 (7.3); 2.1422 (7.6); 2.1390 (6.4); 2.1176 (2.5); 2.0732 (0.5); 2.0400 (0.6); 2.0272 (2.1); 2.0133 (4.7); 2.0048 (4.5); 2.0010 (6.4); 1.9959 (6.3); 1.9854 (6.2); 1.9805 (6.2); 1.9704 (4.2); 1.9572 (2.0); 1.9539 (2.0); 1.6691 (2.4); 1.6543 (6.5); 1.6417 (7.1); 1.6299 (12.1); 1.6157 (6.1); 1.6053 (5.7); 1.5951 (1.7); 1.5898 (2.1); 1.3404 (2.5); 1.3227 (5.5); 1.3050 (2.5); 1.2506 (0.8); 1.2329 (1.8); 1.2150 (0.8); 1.1942 (2.1); 1.1761 (4.3); 1.1578 (2.2); 1.1538 (3.2); 1.1360 (6.0); 1.1183 (2.7); -0.0002 (3.6) I.5-32: 1 H-NMR (400.0 MHz, d6-DMSO): δ= 9.1471 (2.6); 8.3182 (0.6); 7.8979 (2.9); 7.8924 (1.2); 7.8808 (1.9); 7.8750 (9.6); 7.8532 (9.3); 7.8475 (2.0); 7.8361 (1.2); 7.8304 (2.9); 7.4074 (2.1); 7.2666 (1.9); 7.2459 (3.8); 7.2090 (2.6); 7.2034 (2.4); 7.1883 (1.3); 7.1829 (1.3); 4.9908 (0.6); 4.2733 (1.3); 4.2561 (1.6); 4.2472 (1.7); 4.2299 (1.4); 4.0561 (1.0); 4.0383 (3.0); 4.0205 (3.1); 4.0028 (1.0); 3.8198 (1.2); 3.8115 (1.1); 3.7945 (1.0); 3.7859 (1.0); 3.3033 (56.2); 3.0832 (1.4); 3.0624 (1.6); 3.0398 (1.9); 3.0188 (1.6); 2.6737 (1.1); 2.6689 (1.4); 2.6644 (1.0); 2.6182 (1.1); 2.6082 (1.2); 2.5735 (1.0); 2.5639 (1.0); 2.5225 (4.0); 2.5178 (5.7); 2.5091 (81.5); 2.5046 (174.7); 2.5000 (242.2); 2.4954 (169.3); 2.4909 (76.2); 2.3313 (0.9); 2.3267 (1.4); 2.3223 (1.0); 2.1390 (16.0); 1.9875 (14.2); 1.2471 (1.2); 1.1923 (3.6); 1.1745 (7.3); 1.1568 (3.5); 0.8754 (0.6); 0.8584 (1.9); 0.8406 (0.6); 0.0080 (3.0); -0.0002 (96.4); -0.0085 (2.7) I.5-33: 1 H-NMR (400.0 MHz, d 6 -DMSO): δ= 9.1803 (3.6); 8.4015 (1.0); 8.3892 (0.9); 7.7070 (0.8); 7.6865 (0.9); 7.6625 (6.1); 7.6565 (6.3); 7.4150 (4.1); 7.4089 (3.9); 7.3933 (3.5); 7.3872 (3.4); 5.7522 (1.2); 4.7987 (0.6); 4.2024 (0.7); 4.1856 (1.8); 4.1687 (2.6); 4.1517 (1.9); 4.1349 (0.7); 3.6664 (1.7); 3.6491 (1.8); 3.6408 (2.0); 3.6237 (1.8); 3.3053 (46.1); 3.2091 (1.5); 3.1995 (1.5); 3.1835 (1.4); 3.1741 (1.4); 2.7097 (2.2); 2.6888 (2.4); 2.6738 (0.6); 2.6676 (3.2); 2.6468 (2.5); 2.5227 (1.9); 2.5180 (2.7); 2.5094 (42.3); 2.5048 (93.1); 2.5002 (131.3); 2.4955 (92.3); 2.4909 (42.1); 2.4685 (0.6); 2.4637 (0.6); 2.4595 (0.6); 2.4554 (0.6); 2.4508 (0.7); 2.3316 (0.6); 2.3269 (0.8); 2.3224 (0.6); 2.2827 (0.9); 2.2715 (0.9); 2.2396 (0.8); 2.2299 (0.7); 1.0787 (14.4); 1.0655 (15.9); 1.0618 (16.0); 1.0486 (14.4); 0.0080 (2.2); -0.0002 (78.0); -0.0085 (2.5) Gegenstand der vorliegenden Erfindung ist die Verwendung mindestens eines Pyrrolidinons der allgemeinen Formel (I), in Kombination mit weiteren agrochemischen Wirkstoffen wie beispielsweise Fungizide, Insektizide, Herbizide, Pflanzenwachstumsregulatoren oder Safener, zur Steigerung der Widerstandsfähigkeit von Pflanzen gegenüber abiotischen Stressfaktoren, bevorzugt Trockenstress, sowie zur Stärkung des Pflanzenwachstums und/oder zur Erhöhung des Pflanzenertrags. Weiterer Gegenstand der vorliegenden Erfindung ist eine Sprühlösung zur Behandlung von Pflanzen, enthaltend eine zur Steigerung der Widerstandsfähigkeit von Pflanzen gegenüber abiotischen Stressfaktoren wirksame Menge von mindestens einer Verbindung, ausgewählt aus der Gruppe, bestehend aus mindestens einem der erfindungsgemäß substituierten Pyrrolidinone, der allgemeinen Formel (I). Zu den dabei relativierbaren abiotischen Stressbedingungen können zum Beispiel Hitze, Dürre, Kälte- und Trockenstress (Stress verursacht durch Trockenheit und/oder Wassermangel), osmotischer Stress, Staunässe, erhöhter Bodensalzgehalt, erhöhtes Ausgesetztsein an Mineralien, Ozonbedingungen, Starklichtbedingungen, beschränkte Verfügbarkeit von Stickstoffnährstoffen, beschränkte Verfügbarkeit von Phosphornährstoffen zählen. In einer Ausführungsform kann beispielsweise vorgesehen sein, dass eine oder mehrere der erfindungsgemäß zu verwendenden Verbindungen, d. h. die entsprechenden erfindungsgemäß substituierten Pyrrolidinone der allgemeinen Formel (I), durch eine Sprühapplikation auf entsprechend zu behandelnde Pflanzen oder Pflanzenteile aufgebracht werden. Die Verwendung der Verbindungen der allgemeinen Formel (I) oder deren Salze erfolgt vorzugsweise mit einer Dosierung zwischen 0,00005 und 3 kg/ha, besonders bevorzugt zwischen 0,0001 und 2 kg/ha, insbesondere bevorzugt zwischen 0,0005 und 1 kg/ha, im Speziellen bevorzugt zwischen 0,001 und 0,25 kg/ha. Unter der Bezeichnung Resistenz bzw. Widerstandsfähigkeit gegenüber abiotischem Stress werden im Rahmen der vorliegenden Erfindung verschiedenartige Vorteile für Pflanzen verstanden. Solche vorteilhaften Eigenschaften äußern sich beispielsweise in den nachfolgend genannten verbesserten Pflanzencharakteristika: verbessertes Wurzelwachstum hinsichtlich Oberfläche und Tiefe, vermehrte Ausläuferbildung oder Bestockung, stärkere und produktivere Ausläufer und Bestockungstriebe, Verbesserung des Sprosswachstums, erhöhte Standfestigkeit, vergrößerte Sprossbasisdurchmesser, vergrößerte Blattfläche, höhere Erträge an Nähr- und Inhaltsstoffen, wie z.B. Kohlenhydrate, Fette, Öle, Proteine, Vitamine, Mineralstoffe, ätherische Öle, Farbstoffe, Fasern, bessere Faserqualität, früheres Blühen, gesteigerte Blütenanzahl, reduzierter Gehalt an toxischen Produkten wie Mycotoxine, reduzierter Gehalt an Rückständen oder unvorteilhaften Bestandteilen jeglicher Art oder bessere Verdaulichkeit, verbesserte Lagerstabilität des Erntegutes, verbesserter Toleranz gegenüber unvorteilhaften Temperaturen, verbesserter Toleranz gegenüber Dürre und Trockenheit, wie auch Sauerstoffmangel durch Wasserüberschuss, verbesserte Toleranz gegenüber erhöhten Salzgehalten in Böden und Wasser, gesteigerte Toleranz gegenüber Ozonstress, verbesserte Verträglichkeit gegenüber Herbiziden und anderen Pflanzenbehandlungsmitteln, verbesserte Wasseraufnahme und Photosyntheseleistung, vorteilhafte Pflanzeneigenschaften, wie beispielsweise Beschleunigung der Reifung, gleichmäßigere Abreife, größere Anziehungskraft für Nützlinge, verbesserte Bestäubung oder andere Vorteile, die einem Fachmann durchaus bekannt sind. Insbesondere zeigt die Verwendung einer oder mehrerer erfindungsgemäßen Verbindungen der allgemeinen Formel (I) in der Sprühapplikation auf Pflanzen und Pflanzenteilen die beschriebenen Vorteile. Die kombinierte Verwendung von erfindungsgemäßen N-Sulfonyl-N‘-aryldiaminoalkanen und N-Sulfonyl-N‘-heteroaryldiaminoalkanen der allgemeinen Formel (I) mit gentechnisch veränderten Sorten in Bezug auf erhöhte abiotische Stresstoleranz ist darüber hinaus ebenfalls möglich. Die weiter oben genannten verschiedenartigen Vorteile für Pflanzen lassen sich bekannterweise partiell zusammenfassen und mit allgemein gültigen Begriffen belegen. Soche Begriffe sind beispielsweise die nachfolgend aufgeführten Bezeichnungen: phytotonischer Effekt, Widerstandsfähigkeit gegenüber Stressfaktoren, weniger Pflanzenstress, Pflanzengesundheit, gesunde Pflanzen, Pflanzenfitness, („Plant Fitness“), „Plant Wellness“, „Plant Concept“, „Vigor Effect“, „Stress Shield“, Schutzschild, „Crop Health“, „Crop Health Properties“, „Crop Health Products“, „Crop Health Management“, „Crop Health Therapy“, „Plant Health“, Plant Health Properties“, Plant Health Products“, „Plant Health Management“, „Plant Health Therapy“, Grünungseffekt („Greening Effect“ oder „Re-greening Effect“), „Freshness“ oder andere Begriffe, die einem Fachmann durchaus bekannt sind. Im Rahmen der vorliegenden Erfindung wird unter einem guten Effekt auf die Widerstandsfähigkeit gegenüber abiotischem Stress nicht beschränkend • mindestens ein um im Allgemeinen 3 %, insbesondere größer als 5 % besonders bevorzugt größer als 10 % verbessertes Auflaufen, • mindestens einen im Allgemeinen 3 %, insbesondere größer als 5 % besonders bevorzugt größer als 10 % gesteigerten Ertrag, • mindestens eine um im Allgemeinen 3 %, insbesondere größer als 5 % besonders bevorzugt größer als 10 % verbesserte Wurzelentwicklung, • mindestens eine um im Allgemeinen 3 %, insbesondere größer als 5 % besonders bevorzugt größer als 10 % ansteigende Sprossgröße, • mindestens eine um im Allgemeinen 3 %, insbesondere größer als 5 % besonders bevorzugt größer als 10 % vergrößerte Blattfläche, • mindestens eine um im Allgemeinen 3 %, insbesondere größer als 5 % besonders bevorzugt größer als 10 % verbesserte Photosyntheseleistung und/oder • mindestens eine um im Allgemeinen 3 %, insbesondere größer als 5 % besonders bevorzugt größer als 10 % verbesserte Blütenausbildung verstanden, wobei die Effekte einzeln oder aber in beliebiger Kombination von zwei oder mehreren Effekten auftreten können. Weiterer Gegenstand der vorliegenden Erfindung ist eine Sprühlösung zur Behandlung von Pflanzen, enthaltend eine zur Steigerung der Widerstandsfähigkeit von Pflanzen gegenüber abiotischen Stressfaktoren wirksame Menge von mindestens einer Verbindung aus der Gruppe der erfindungsgemäß substituierten Pyrrolidinone der allgemeinen Formel (I). Die Sprühlösung kann andere übliche Bestandteile aufweisen, wie Lösungsmittel, Formulierhilfsstoffe, insbesondere Wasser, enthalten. Weitere Bestandteile können unter anderem agrochemische Wirkstoffe sein, welche unten noch weiter beschrieben werden. Weiterer Gegenstand der vorliegenden Erfindung ist die Verwendung von entsprechenden Sprühlösungen zur Steigerung der Widerstandsfähigkeit von Pflanzen gegenüber abiotischen Stressfaktoren. Die nachfolgenden Ausführungen gelten sowohl für die Verwendung einer oder mehrerer erfindungsgemäßer Verbindungen der allgemeinen Formel (I) an sich als auch für die entsprechenden Sprühlösungen. Es wurde darüber hinausgefunden, dass die Anwendung einer oder mehrerer erfindungsgemäßer Verbindungen der allgemeinen Formel (I) in Kombination mit mindestens einem Düngemittel wie weiter unten tehend definiert auf Pflanzen oder in deren Umgebung möglich ist. Düngemittel, die erfindungsgemäß zusammen mit den oben näher erläuterten erfindungsgemäßen Verbindungen der allgemeinen Formel (I) verwendet werden können, sind im Allgemeinen organische und anorganische Stickstoff-haltige Verbindungen wie beispielsweise Harnstoffe, Harnstoff- Formaldehyd-Kondensationsprodukte, Aminosäuren, Ammoniumsalze und -nitrate, Kaliumsalze (bevorzugt Chloride, Sulfate, Nitrate), Phosphorsäuresalze und/oder Salze von Phosphoriger Säure (bevorzugt Kaliumsalze und Ammoniumsalze). Insbesondere zu nennen sind in diesem Zusammenhang die NPK-Dünger, d.h. Düngemittel, die Stickstoff, Phosphor und Kalium enthalten, Kalkammonsalpeter, d.h. Düngemittel, die noch Calcium enthalten, Ammonsulfatsalpeter (Allgemeine Formel (NH4)2SO4 NH4NO3), Ammonphosphat und Ammonsulfat. Diese Düngemittel sind dem Fachmann allgemein bekannt, siehe auch beispielsweise Ullmann's Encyclopedia of Industrial Chemistry, 5. Edition, Vol. A 10, Seiten 323 bis 431, Verlagsgesellschaft, Weinheim, 1987. Die Düngemittel können auch Salze aus Mikronährstoffen (bevorzugt Calcium, Schwefel, Bor, Mangan, Magnesium, Eisen, Bor, Kupfer, Zink, Molybdän und Kobalt) und Phytohormonen (z. B. Vitamin B1 und Indol-(III)essigsäure) oder Gemische davon enthalten. Erfindungsgemäß eingesetzte Düngemittel können auch weitere Salze wie Monoammoniumphosphat (MAP), Diammoniumphosphat (DAP), Kaliumsulfat, Kaliumchlorid, Magnesiumsulfat enthalten. Geeignete Mengen für die sekundären Nährstoffe oder Spurenelemente sind Mengen von 0,5 bis 5 Gew.-%, bezogen auf das gesamte Düngemittel. Weitere mögliche Inhaltsstoffe sind Pflanzenschutzmittel, Insektizide, Fungizide, Safener oder Wachstumsregulatoren oder Gemische davon. Hierzu folgen weiter unten weitergehende Ausführungen. Die Düngemittel können beispielsweise in Form von Pulvern, Granulaten, Prills oder Kompaktaten eingesetzt werden. Die Düngemittel können jedoch auch in flüssiger Form, gelöst in einem wässrigen Medium, eingesetzt werden. In diesem Fall kann auch verdünnter wässriger Ammoniak als Stickstoffdüngemittel eingesetzt werden. Weitere mögliche Inhaltsstoffe für Düngemittel sind beispielsweise in Ullmann's Encyclopedia of Industrial Chemistry, 5. Auflage, 1987, Band A 10, Seiten 363 bis 401, DE-A 4128828, DE-A 1905834 und DE-A 19631764 beschrieben. Die allgemeine Zusammensetzung der Düngemittel, bei welchen es sich im Rahmen der vorliegenden Erfindung um Einzelnährstoff- und/oder Mehrnährstoffdünger handeln kann, beispielsweise aus Stickstoff, Kalium oder Phosphor, kann innerhalb eines breiten Bereichs variieren. Im Allgemeinen ist ein Gehalt von 1 bis 30 Gew.-% Stickstoff (bevorzugt 5 bis 20 Gew.-%), von 1 bis 20 Gew.-% Kalium (bevorzugt 3 bis 15 Gew.-%) und ein Gehalt von 1 bis 20 Gew.-% Phosphor (bevorzugt 3 bis 10 Gew.-%) vorteilhaft. Der Gehalt von Mikroelementen ist üblicherweise im ppm-Bereich, bevorzugt im Bereich von von 1 bis 1000 ppm. Im Rahmen der vorliegenden Erfindung können das Düngemittel sowie eine oder mehrere erfindungsgemäße Verbindungen der allgemeinen Formel (I) zeitgleich verabreicht werden. Es ist jedoch auch möglich, zunächst das Düngemittel und dann eine oder mehrere erfindungsgemäße Verbindungen der allgemeinen Formel (I) oder zunächst eine oder mehrere Verbindungen der allgemeinen Formel (I) und dann das Düngemittel anzuwenden. Bei nicht zeitgleicher Anwendung einer oder mehrerer Verbindungen der allgemeinen Formel (I) und des Düngemittels erfolgt im Rahmen der vorliegenden Erfindung jedoch die Anwendung in funktionellem Zusammenhang, insbesondere innerhalb eines Zeitraums von im Allgemeinen 24 Stunden, bevorzugt 18 Stunden, besonders bevorzugt 12 Stunden, speziell 6 Stunden, noch spezieller 4 Stunden, noch weiter spezieller innerhalb 2 Stunden. In ganz besonderen Ausführungsformen der vorliegenden Erfindung erfolgt die Anwendung einer oder mehrerer erfindungsgemäßer Verbindungen der Formel (I) und des Düngemittels in einem zeitlichen Rahmen von weniger als 1 Stunden, vorzugsweise weniger als 30 Minuten, besonders bevorzugt weniger als 15 Minuten. Bevorzugt ist die Verwendung von erfindungsgemäßen Verbindungen der allgemeinen Formel (I) auf Pflanzen aus der Gruppe der Nutzpflanzen, Zierpflanzen, Rasenarten, allgemein genutzte Bäume, die in öffentlichen und privaten Bereichen als Zierpflanzen Verwendungen finden, und Forstbestand. Der Forstbestand umfasst Bäume für die Herstellung von Holz, Zellstoff, Papier und Produkten die aus Teilen der Bäume hergestellt werden. Der Begriff Nutzpflanzen, wie hier verwendet, bezeichnet Kulturpflanzen, die als Pflanzen für die Gewinnung von Nahrungsmitteln, Futtermitteln, Treibstoffe oder für technische Zwecke eingesetzt werden. Zu den Nutzpflanzen zählen z. B. folgende Pflanzenarten: Triticale, Durum (Hartweizen), Turf, Reben, Getreide, beispielsweise Weizen, Gerste, Roggen, Hafer, Reis, Mais und Hirse; Rüben, beispielsweise Zuckerrüben und Futterrüben; Früchte, beispielsweise Kernobst, Steinobst und Beerenobst, beispielsweise Äpfel, Birnen, Pflaumen, Pfirsiche, Mandeln, Kirschen und Beeren, z. B. Erdbeeren, Himbeeren, Brombeeren; Hülsenfrüchte, beispielsweise Bohnen, Linsen, Erbsen und Sojabohnen; Ölkulturen, beispielsweise Raps, Senf, Mohn, Oliven, Sonnenblumen, Kokos, Castorölpflanzen, Kakaobohnen und Erdnüsse; Gurkengewächse, beispielsweise Kürbis, Gurken und Melonen; Fasergewächse, beispielsweise Baumwolle, Flachs, Hanf und Jute; Citrusfrüchte, beispielsweise Orangen, Zitronen, Pampelmusen und Mandarinen; Gemüsesorten, beispielsweise Spinat, (Kopf)-Salat, Spargel, Kohlarten, Möhren, Zwiebeln, Tomaten, Kartoffeln und Paprika; Lorbeergewächse, beispielsweise Avocado, Cinnamomum, Kampfer, oder ebenso Pflanzen wie Tabak, Nüsse, Kaffee, Aubergine, Zuckerrohr, Tee, Pfeffer, Weinreben, Hopfen, Bananen, Naturkautschukgewächse sowie Zierpflanzen, beispielsweise Blumen, Sträucher, Laubbäume und Nadelbäume wie Koniferen. Diese Aufzählung stellt keine Limitierung dar. Als besonders geeignete Zielkulturen für die Anwendung des erfindungsgemäßen Verfahrens sind folgende Pflanzen anzusehen: Hafer, Roggen, Triticale, Durum, Baumwolle, Aubergine, Turf, Kernobst, Steinobst, Beerenobst, Mais, Weizen, Gerste, Gurke, Tabak, Reben, Reis, Getreide, Birne, Pfeffer, Bohnen, Sojabohnen, Raps, Tomate, Paprika, Melonen, Kohl, Kartoffel und Apfel. Als Bäume, die entsprechend dem erfindungsgemäßen Verfahren verbessert werden können, seien beispielhaft genannt: Abies sp., Eucalyptus sp., Picea sp., Pinus sp., Aesculus sp., Platanus sp., Tilia sp., Acer sp., Tsuga sp., Fraxinus sp., Sorbus sp., Betula sp., Crataegus sp., Ulmus sp., Quercus sp., Fagus sp., Salix sp., Populus sp.. Als bevorzugte Bäume, die entsprechend dem erfindungsgemäßen Verfahren verbessert werden können, können genannt werden: Aus der Baumart Aesculus: A. hippocastanum, A. pariflora, A. carnea; aus der Baumart Platanus: P. aceriflora, P. occidentalis, P. racemosa; aus der Baumart Picea: P. abies; aus der Baumart Pinus: P. radiate, P. ponderosa, P. contorta, P. sylvestre, P. elliottii, P. montecola, P. albicaulis, P. resinosa, P. palustris, P. taeda, P. flexilis, P. jeffregi, P. baksiana, P. strobes; aus der Baumart Eucalyptus: E. grandis, E. globulus, E. camadentis, E. nitens, E. obliqua, E. regnans, E. pilularus. Als besonders bevorzugte Bäume, die entsprechend dem erfindungsgemäßen Verfahren verbessert werden können, können genannt werden: Aus der Baumart Pinus: P. radiate, P. ponderosa, P. contorta, P. sylvestre, P. strobes; aus der Baumart Eucalyptus: E. grandis, E. globulus und E. camadentis. Als besonders bevorzugte Bäume, die entsprechend dem erfindungsgemäßen Verfahren verbessert werden können, können genannt werden: Rosskastanie, Platanengewächs, Linde und Ahornbaum. Die vorliegende Erfindung kann auch an beliebigen Rasenarten („turfgrasses“) durchgeführt werden, einschließlich „cool season turfgrasses“ und „warm season turfgrasses“. Beispiele für Rasenarten für die kalte Jahreszeit sind Blaugräser („blue grasses“; Poa spp.), wie „Kentucky bluegrass“ (Poa pratensis L.), „rough bluegrass“ (Poa trivialis L.), „Canada bluegrass“ (Poa compressa L.), „annual bluegrass“ (Poa annua L.), „upland bluegrass“ (Poa glaucantha Gaudin), „wood bluegrass“ (Poa nemoralis L.) und „bulbous bluegrass“ (Poa bulbosa L.); Straussgräser („Bentgrass“, Agrostis spp.), wie „creeping bentgrass“ (Agrostis palustris Huds.), „colonial bentgrass“ (Agrostis tenuis Sibth.), „velvet bentgrass“ (Agrostis canina L.), „South German Mixed Bentgrass“ (Agrostis spp. einschließlich Agrostis tenius Sibth., Agrostis canina L., und Agrostis palustris Huds.), und „redtop“ (Agrostis alba L.); Schwingel („Fescues“, Festucu spp.), wie „red fescue“ (Festuca rubra L. spp. rubra), „creeping fescue“ (Festuca rubra L.), „chewings fescue“ (Festuca rubra commutata Gaud.), „sheep fescue“ (Festuca ovina L.), „hard fescue“ (Festuca longifolia Thuill.), „hair fescue“ (Festucu capillata Lam.), „tall fescue“ (Festuca arundinacea Schreb.) und „meadow fescue“ (Festuca elanor L.); Lolch („ryegrasses“, Lolium spp.), wie „annual ryegrass“ (Lolium multiflorum Lam.), „perennial ryegrass“ (Lolium perenne L.) und „italian ryegrass“ (Lolium multiflorum Lam.); und Weizengräser (“wheatgrasses”, Agropyron spp..), wie “fairway wheatgrass” (Agropyron cristatum (L.) Gaertn.), „crested wheatgrass“ (Agropyron desertorum (Fisch.) Schult.) und “western wheatgrass” (Agropyron smithii Rydb.). Beispiele für weitere “cool season turfgrasses” sind “beachgrass” (Ammophila breviligulata Fern.), “smooth bromegrass” (Bromus inermis Leyss.), Schilf (“cattails”) wie “Timothy” (Phleum pratense L.), “sand cattail” (Phleum subulatum L.), “orchardgrass” (Dactylis glomerata L.), “weeping alkaligrass” (Puccinellia distans (L.) Parl.) und “crested dog’s-tail” (Cynosurus cristatus L.). Beispiele für “warm season turfgrasses” sind „Bermudagrass“ (Cynodon spp. L. C. Rich), “zoysiagrass” (Zoysia spp. Willd.), „St. Augustine grass“ (Stenotaphrum secundatum Walt Kuntze), „centipedegrass“ (Eremochloa ophiuroides Munro Hack.), „carpetgrass“ (Axonopus affinis Chase), „Bahia grass“ (Paspalum notatum Flugge), „Kikuyugrass“ (Pennisetum clandestinum Hochst. ex Chiov.), „buffalo grass“ (Buchloe dactyloids (Nutt.) Engelm.), “Blue gramma” (Bouteloua gracilis (H.B.K.) Lag. ex Griffiths), „seashore paspalum“ (Paspalum vaginatum Swartz) und „sideoats grama“ (Bouteloua curtipendula (Michx. Torr.). “Cool season turfgrasses” sind für die erfindungsgemäße Verwendung im Allgemeinen bevorzugt. Besonders bevorzugt sind Blaugras, Straussgras und „redtop“, Schwingel und Lolch. Straussgras ist insbesondere bevorzugt. Besonders bevorzugt werden mit den erfindungsgemäßen Verbindungen der allgemeinen Formel (I) Pflanzen der jeweils handelsüblichen oder in Gebrauch befindlichen Pflanzensorten behandelt. Unter Pflanzensorten versteht man Pflanzen mit neuen Eigenschaften ("Traits"), die sowohl durch konven- tionelle Züchtung, durch Mutagenese oder mit Hilfe rekombinanter DNA-Techniken, gezüchtet worden sind. Kulturpflanzen können demnach Pflanzen sein, die durch konventionelle Züchtungs- und Optimierungsmethoden oder durch biotechnologische und gentechnologische Methoden oder Kombinationen dieser Methoden erhalten werden können, einschließlich der transgenen Pflanzen und einschließlich der durch Sortenschutzrechte schützbaren oder nicht schützbaren Pflanzensorten. Das erfindungsgemäße Behandlungsverfahren kann somit auch für die Behandlung von genetisch modifizierten Organismen (GMOs), z. B. Pflanzen oder Samen, verwendet werden. Genetisch modifizierte Pflanzen (oder transgene Pflanzen) sind Pflanzen, bei denen ein heterologes Gen stabil in das Genom integriert worden ist. Der Begriff "heterologes Gen" bedeutet im Wesentlichen ein Gen, das außerhalb der Pflanze bereitgestellt oder assembliert wird und das bei Einführung in das Zellkerngenom, das Chloroplastengenom oder das Hypochondriengenom der transformierten Pflanze dadurch neue oder verbesserte agronomische oder sonstige Eigenschaften verleiht, dass es ein interessierendes Protein oder Polypeptid exprimiert oder dass es ein anderes Gen, das in der Pflanze vorliegt bzw. andere Gene, die in der Pflanze vorliegen, herunterreguliert oder abschaltet (zum Beispiel mittels Antisense-Technologie, Co-suppressionstechnologie oder RNAi-Technologie [RNA Interference]). Ein heterologes Gen, das im Genom vorliegt, wird ebenfalls als Transgen bezeichnet. Ein Transgen, das durch sein spezifisches Vorliegen im Pflanzengenom definiert ist, wird als Transformations- bzw. transgenes Event bezeichnet. Zu Pflanzen und Pflanzensorten, die vorzugsweise mit den erfindungsgemäßen Verbindungen der allgemeinen Formel (I) behandelt werden, zählen alle Pflanzen, die über Erbgut verfügen, das diesen Pflanzen besonders vorteilhafte, nützliche Merkmale verleiht (egal, ob dies durch Züchtung und/oder Biotechnologie erzielt wurde). Pflanzen und Pflanzensorten, die ebenfalls mit den erfindungsgemäßen Verbindungen der allgemeinen Formel (I) behandelt werden können, sind solche Pflanzen, die gegen einen oder mehrere abiotische Stressfaktoren resistent sind. Zu den abiotischen Stressbedingungen können zum Beispiel Hitze, Dürre, Kälte- und Trockenstress,, osmotischer Stress, Staunässe, erhöhter Bodensalzgehalt, erhöhtes Ausgesetztsein an Mineralien, Ozonbedingungen, Starklichtbedingungen, beschränkte Verfügbarkeit von Stickstoffnährstoffen, beschränkte Verfügbarkeit von Phosphornährstoffen oder Vermeidung von Schatten zählen. Pflanzen und Pflanzensorten, die ebenfalls mit den erfindungsgemäßen Verbindungen der allgemeinen Formel (I) behandelt werden können, sind solche Pflanzen, die durch erhöhte Ertragseigenschaften gekennzeichnet sind. Ein erhöhter Ertrag kann bei diesen Pflanzen z. B. auf verbesserter Pflanzenphysiologie, verbessertem Pflanzenwuchs und verbesserter Pflanzenentwicklung, wie Wasserverwertungseffizienz, Wasserhalteeffizienz, verbesserter Stickstoffverwertung, erhöhter Kohlenstoffassimilation, verbesserter Photosynthese, verstärkter Keimkraft und beschleunigter Abreife beruhen. Der Ertrag kann weiterhin durch eine verbesserte Pflanzenarchitektur (unter Stress- und nicht- Stress-Bedingungen) beeinflusst werden, darunter frühe Blüte, Kontrolle der Blüte für die Produktion von Hybridsaatgut, Keimpflanzenwüchsigkeit, Pflanzengröße, Internodienzahl und -abstand, Wurzelwachstum, Samengröße, Fruchtgröße, Schotengröße, Schoten- oder Ährenzahl, Anzahl der Samen pro Schote oder Ähre, Samenmasse, verstärkte Samenfüllung, verringerter Samenausfall, verringertes Schotenplatzen sowie Standfestigkeit. Zu weiteren Ertragsmerkmalen zählen Samenzusammensetzung wie Kohlenhydratgehalt, Proteingehalt, Ölgehalt und Ölzusammensetzung, Nährwert, Verringerung der nährwidrigen Verbindungen, verbesserte Verarbeitbarkeit und verbesserte Lagerfähigkeit. Pflanzen, die ebenfalls mit den erfindungsgemäßen Verbindungen der allgemeinen Formel (I) behandelt werden können, sind Hybridpflanzen, die bereits die Eigenschaften der Heterosis bzw. des Hybrideffekts exprimieren, was im allgemeinen zu höherem Ertrag, höherer Wüchsigkeit, besserer Gesundheit und besserer Resistenz gegen biotische und abiotische Stressfaktoren führt. Solche Pflanzen werden typischerweise dadurch erzeugt, dass man eine ingezüchtete pollensterile Elternlinie (den weiblichen Kreuzungspartner) mit einer anderen ingezüchteten pollenfertilen Elternlinie (dem männlichen Kreuzungspartner) kreuzt. Das Hybridsaatgut wird typischerweise von den pollensterilen Pflanzen geerntet und an Vermehrer verkauft. Pollensterile Pflanzen können manchmal (z. B. beim Mais) durch Entfahnen (d. h. mechanischem Entfernen der männlichen Geschlechtsorgane bzw. der männlichen Blüten), produziert werden; es ist jedoch üblicher, dass die Pollensterilität auf genetischen Determinanten im Pflanzengenom beruht. In diesem Fall, insbesondere dann, wenn es sich bei dem gewünschten Produkt, da man von den Hybridpflanzen ernten will, um die Samen handelt, ist es üblicherweise günstig, sicherzustellen, dass die Pollenfertilität in Hybridpflanzen, die die für die Pollensterilität verantwortlichen genetischen Determinanten enthalten, völlig restoriert wird. Dies kann erreicht werden, indem sichergestellt wird, dass die männlichen Kreuzungspartner entsprechende Fertilitätsrestorergene besitzen, die in der Lage sind, die Pollenfertilität in Hybridpflanzen, die die genetischen Determinanten, die für die Pollensterilität verantwortlich sind, enthalten, zu restorieren. Genetische Determinanten für Pollensterilität können im Cytoplasma lokalisiert sein. Beispiele für cytoplasmatische Pollensterilität (CMS) wurden zum Beispiel für Brassica-Arten beschrieben (WO92/005251, WO95/009910, WO98/27806, WO2005/002324, WO2006/021972 und US6,229,072). Genetische Determinanten für Pollensterilität können jedoch auch im Zellkerngenom lokalisiert sein. Pollensterile Pflanzen können auch mit Methoden der pflanzlichen Biotechnologie, wie Gentechnik, erhalten werden. Ein besonders günstiges Mittel zur Erzeugung von pollensterilen Pflanzen ist in WO 89/10396 beschrieben, wobei zum Beispiel eine Ribonuklease wie eine Barnase selektiv in den Tapetumzellen in den Staubblättern exprimiert wird. Die Fertilität kann dann durch Expression eines Ribonukleasehemmers wie Barstar in den Tapetumzellen restoriert werden (z. B. WO91/002069). Pflanzen oder Pflanzensorten (die mit Methoden der Pflanzenbiotechnologie, wie der Gentechnik, erhalten werden), die ebenfalls mit den erfindungsgemäßen Verbindungen der allgemeinen Formel (I) behandelt werden können, sind herbizidtolerante Pflanzen, d. h. Pflanzen, die gegenüber einem oder mehreren vorgegebenen Herbiziden tolerant gemacht worden sind. Solche Pflanzen können entweder durch genetische Transformation oder durch Selektion von Pflanzen, die eine Mutation enthalten, die solch eine Herbizidtoleranz verleiht, erhalten werden. Herbizidtolerante Pflanzen sind zum Beispiel glyphosatetolerante Pflanzen, d. h. Pflanzen, die gegenüber dem Herbizid Glyphosate oder dessen Salzen tolerant gemacht worden sind. So können zum Beispiel glyphosatetolerante Pflanzen durch Transformation der Pflanze mit einem Gen, das für das Enzym 5-Enolpyruvylshikimat-3-phosphatsynthase (EPSPS) kodiert, erhalten werden. Beispiele für solche EPSPS-Gene sind das AroA-Gen (Mutante CT7) des Bakterium Salmonella typhimurium (Comai et al., Science (1983), 221, 370-371), das CP4-Gen des Bakteriums Agrobacterium sp. (Barry et al., Curr. Topics Plant Physiol. (1992), 7, 139-145), die Gene, die für eine EPSPS aus der Petunie (Shah et al., Science (1986), 233, 478-481), für eine EPSPS aus der Tomate (Gasser et al., J. Biol. Chem. (1988), 263, 4280-4289) oder für eine EPSPS aus Eleusine (WO2001/66704) kodieren. Es kann sich auch um eine mutierte EPSPS handeln, wie sie zum Beispiel in EP-A 0837944, WO2000/066746, WO2000/066747 oder WO2002/026995 beschrieben ist. Glyphosatetolerante Pflanzen können auch dadurch erhalten werden, dass man ein Gen exprimiert, das für ein Glyphosate-Oxidoreduktase-Enzym, wie es in US5,776,760 und US5,463,175 beschrieben ist, kodiert. Glyphosatetolerante Pflanzen können auch dadurch erhalten werden, dass man ein Gen exprimiert, das für ein Glyphosate-acetyltransferase- Enzym, wie es in z. B. WO2002/036782, WO2003/092360, WO2005/012515 und WO2007/024782 beschrieben ist, kodiert. Glyphosatetolerante Pflanzen können auch dadurch erhalten werden, dass man Pflanzen, die natürlich vorkommende Mutationen der oben erwähnten Gene, wie sie zum Beispiel in WO01/024615 oder WO2003/013226 beschrieben sind, enthalten, selektiert. Sonstige herbizidresistente Pflanzen sind zum Beispiel Pflanzen, die gegenüber Herbiziden, die das Enzym Glutaminsynthase hemmen, wie Bialaphos, Phosphinotricin oder Glufosinate, tolerant gemacht worden sind. Solche Pflanzen können dadurch erhalten werden, dass man ein Enzym exprimiert, das das Herbizid oder eine Mutante des Enzyms Glutaminsynthase, das gegenüber Hemmung resistent ist, entgiftet. Solch ein wirksames entgiftendes Enzym ist zum Beispiel ein Enzym, das für ein Phosphinotricin-acetyltransferase kodiert (wie zum Beispiel das bar- oder pat-Protein aus Streptomyces- Arten). Pflanzen, die eine exogene Phosphinotricin-acetyltransferase exprimieren, sind zum Beispiel in US5,561,236; US5,648,477; US5,646,024; US5,273,894; US5,637,489; US5,276,268; US5,739,082; US5,908,810 und US7,112,665 beschrieben. Weitere herbizidtolerante Pflanzen sind auch Pflanzen, die gegenüber den Herbiziden, die das Enzym Hydroxyphenylpyruvatdioxygenase (HPPD) hemmen, tolerant gemacht worden sind. Bei den Hydroxyphenylpyruvatdioxygenasen handelt es sich um Enzyme, die die Reaktion, in der para- Hydroxyphenylpyruvat (HPP) zu Homogentisat umgesetzt wird, katalysieren. Pflanzen, die gegenüber HPPD-Hemmern tolerant sind, können mit einem Gen, das für ein natürlich vorkommendes resistentes HPPD-Enzym kodiert, oder einem Gen, das für ein mutiertes HPPD-Enzym gemäß WO96/038567, WO99/024585 und WO99/024586 kodiert, transformiert werden. Eine Toleranz gegenüber HPPD- Hemmern kann auch dadurch erzielt werden, dass man Pflanzen mit Genen transformiert, die für gewisse Enzyme kodieren, die die Bildung von Homogentisat trotz Hemmung des nativen HPPD- Enzyms durch den HPPD-Hemmer ermöglichen. Solche Pflanzen und Gene sind in WO99/034008 und WO2002/36787 beschrieben. Die Toleranz von Pflanzen gegenüber HPPD-Hemmern kann auch dadurch verbessert werden, dass man Pflanzen zusätzlich zu einem Gen, das für ein HPPD-tolerantes Enzym kodiert, mit einem Gen transformiert, das für ein Prephenatdehydrogenase-Enzym kodiert, wie dies in WO2004/024928 beschrieben ist. Weitere herbizidresistente Pflanzen sind Pflanzen, die gegenüber Acetolactatsynthase (ALS)-Hemmern tolerant gemacht worden sind. Zu bekannten ALS-Hemmern zählen zum Beispiel Sulfonylharnstoff, Imidazolinon, Triazolopyrimidine, Pyrimidinyloxy(thio)benzoate und/oder Sulfonylaminocarbonyl- triazolinon-Herbizide. Es ist bekannt, dass verschiedene Mutationen im Enzym ALS (auch als Acetohydroxysäure-Synthase, AHAS, bekannt) eine Toleranz gegenüber unterschiedlichen Herbiziden bzw. Gruppen von Herbiziden verleihen, wie dies zum Beispiel bei Tranel und Wright, Weed Science (2002), 50, 700-712, jedoch auch in US5,605,011, US5,378,824, US5,141,870 und US5,013,659, beschrieben ist. Die Herstellung von sulfonylharnstofftoleranten Pflanzen und imidazolinontoleranten Pflanzen ist in US5,605,011; US5,013,659; US5,141,870; US5,767,361; US5,731,180; US5,304,732; US4,761,373; US5,331,107; US5,928,937; und US5,378,824; sowie in der internationalen Veröffentlichung WO96/033270 beschrieben. Weitere imidazolinontolerante Pflanzen sind auch in z. B. WO2004/040012, WO2004/106529, WO2005/020673, WO2005/093093, WO2006/007373, WO2006/015376, WO2006/024351 und WO2006/060634 beschrieben. Weitere sulfonylharnstoff- und imidazolinontolerante Pflanzen sind auch in z.B. WO2007/024782 beschrieben. Weitere Pflanzen, die gegenüber ALS-Inhibitoren, insbesondere gegenüber Imidazolinonen, Sulfonylharnstoffen und/oder Sulfamoylcarbonyltriazolinonen tolerant sind, können durch induzierte Mutagenese, Selektion in Zellkulturen in Gegenwart des Herbizids oder durch Mutationszüchtung erhalten werden, wie dies zum Beispiel für die Sojabohne in US5,084,082, für Reis in WO97/41218, für die Zuckerrübe in US5,773,702 und WO99/057965, für Salat in US5,198,599 oder für die Sonnenblume in WO2001/065922 beschrieben ist. Pflanzen oder Pflanzensorten (die nach Methoden der pflanzlichen Biotechnologie, wie der Gentechnik, erhalten wurden), die ebenfalls mit den erfindungsgemäßen Verbindungen der allgemeinen Formel (I) behandelt werden können, sind insektenresistente transgene Pflanzen, d.h. Pflanzen, die gegen Befall mit gewissen Zielinsekten resistent gemacht wurden. Solche Pflanzen können durch genetische Transformation oder durch Selektion von Pflanzen, die eine Mutation enthalten, die solch eine Insektenresistenz verleiht, erhalten werden. Der Begriff "insektenresistente transgene Pflanze" umfasst im vorliegenden Zusammenhang jegliche Pflanze, die mindestens ein Transgen enthält, das eine Kodiersequenz umfasst, die für folgendes kodiert: 1) ein insektizides Kristallprotein aus Bacillus thuringiensis oder einen insektiziden Teil davon, wie die insektiziden Kristallproteine, die von Crickmore et al., Microbiology and Molecular Biology Reviews (1998), 62, 807-813, zusammengestellt wurden, von Crickmore et al. (2005) in der Bacillus thuringiensis-Toxinnomenklatur aktualisiert (online bei: http://www.lifesci.sussex.ac.uk/Home/Neil_Crickmore/Bt/), oder insektizide Teile davon, z.B. Proteine der Cry-Proteinklassen Cry1Ab, Cry1Ac, Cry1F, Cry2Ab, Cry3Ae oder Cry3Bb oder insektizide Teile davon; oder 2) ein Kristallprotein aus Bacillus thuringiensis oder einen Teil davon, der in Gegenwart eines zweiten, anderen Kristallproteins als Bacillus thuringiensis oder eines Teils davon insektizid wirkt, wie das binäre Toxin, das aus den Kristallproteinen Cy34 und Cy35 besteht (Moellenbeck et al., Nat. Biotechnol. (2001), 19, 668-72; Schnepf et al., Applied Environm. Microb. (2006), 71, 1765-1774); oder 3) ein insektizides Hybridprotein, das Teile von zwei unterschiedlichen insektiziden Kristallproteinen aus Bacillus thuringiensis umfasst, wie zum Beispiel ein Hybrid aus den Proteinen von 1) oben oder ein Hybrid aus den Proteinen von 2) oben, z. B. das Protein Cry1A.105, das von dem Mais- Event MON98034 produziert wird (WO2007/027777); oder 4) ein Protein gemäß einem der Punkte 1) bis 3) oben, in dem einige, insbesondere 1 bis 10, Aminosäuren durch eine andere Aminosäure ersetzt wurden, um eine höhere insektizide Wirksamkeit gegenüber einer Zielinsektenart zu erzielen und/oder um das Spektrum der entsprechenden Zielinsektenarten zu erweitern und/oder wegen Veränderungen, die in die Kodier- DNA während der Klonierung oder Transformation induziert wurden, wie das Protein Cry3Bb1 in Mais-Events MON863 oder MON88017 oder das Protein Cry3A im Mais-Event MIR 604; oder 5) ein insektizides sezerniertes Protein aus Bacillus thuringiensis oder Bacillus cereus oder einen insektiziden Teil davon, wie die vegetativ wirkenden insektentoxischen Proteine (vegetative insecticidal proteins, VIP), die unter folgendem Link angeführt sind, z. B. Proteine der Proteinklasse VIP3Aa: http://www.lifesci.sussex.ac.uk/Home/Neil_Crickmore/Bt/vip.h tml oder 6) ein sezerniertes Protein aus Bacillus thuringiensis oder Bacillus cereus, das in Gegenwart eines zweiten sezernierten Proteins aus Bacillus thuringiensis oder B. cereus insektizid wirkt, wie das binäre Toxin, das aus den Proteinen VIP1A und VIP2A besteht (WO94/21795); oder 7) ein insektizides Hybridprotein, das Teile von verschiedenen sezernierten Proteinen von Bacillus thuringiensis oder Bacillus cereus umfasst, wie ein Hybrid der Proteine von 1) oder ein Hybrid der Proteine von 2) oben; oder 8) ein Protein gemäß einem der Punkte 1) bis 3) oben, in dem einige, insbesondere 1 bis 10, Aminosäuren durch eine andere Aminosäure ersetzt wurden, um eine höhere insektizide Wirksamkeit gegenüber einer Zielinsektenart zu erzielen und/oder um das Spektrum der entsprechenden Zielinsektenarten zu erweitern und/oder wegen Veränderungen, die in die Kodier- DNA während der Klonierung oder Transformation induziert wurden (wobei die Kodierung für ein insektizides Protein erhalten bleibt), wie das Protein VIP3Aa im Baumwoll-Event COT 102. Natürlich zählt zu den insektenresistenten transgenen Pflanzen im vorliegenden Zusammenhang auch jegliche Pflanze, die eine Kombination von Genen umfasst, die für die Proteine von einer der oben genannten Klassen 1 bis 8 kodieren. In einer Ausführungsform enthält eine insektenresistente Pflanze mehr als ein Transgen, das für ein Protein nach einer der oben genannten 1 bis 8 kodiert, um das Spektrum der entsprechenden Zielinsektenarten zu erweitern oder um die Entwicklung einer Resistenz der Insekten gegen die Pflanzen dadurch hinauszuzögern, dass man verschiedene Proteine einsetzt, die für dieselbe Zielinsektenart insektizid sind, jedoch eine unterschiedliche Wirkungsweise, wie Bindung an unterschiedliche Rezeptorbindungsstellen im Insekt, aufweisen. Pflanzen oder Pflanzensorten (die nach Methoden der pflanzlichen Biotechnologie, wie der Gentechnik, erhalten wurden), die ebenfalls mit den erfindungsgemäßen Verbindungen der allgemeinen Formel (I) behandelt werden können, sind gegenüber abiotischen Stressfaktoren tolerant. Solche Pflanzen können durch genetische Transformation oder durch Selektion von Pflanzen, die eine Mutation enthalten, die solch eine Stressresistenz verleiht, erhalten werden. Zu besonders nützlichen Pflanzen mit Stresstoleranz zählen folgende: a. Pflanzen, die ein Transgen enthalten, das die Expression und/oder Aktivität des Gens für die Poly(ADP-ribose)polymerase (PARP) in den Pflanzenzellen oder Pflanzen zu reduzieren vermag, wie dies in WO2000/004173 oder EP04077984.5 oder EP06009836.5 beschrieben ist. b. Pflanzen, die ein stresstoleranzförderndes Transgen enthalten, das die Expression und/oder Aktivität der für PARG kodierenden Gene der Pflanzen oder Pflanzenzellen zu reduzieren vermag, wie dies z.B. in WO2004/090140 beschrieben ist; c. Pflanzen, die ein stresstoleranzförderndes Transgen enthalten, das für ein in Pflanzen funktionelles Enzym des Nicotinamidadenindinukleotid-Salvage-Biosynthesewegs kodiert, darunter Nicotinamidase, Nicotinatphosphoribosyltransferase, Nicotinsäuremononukleotid-adenyltransferase, Nicotinamidadenindinukleotidsynthetase oder Nicotinamidphosphoribosyl-transferase, wie dies z. B. in EP04077624.7 oder WO2006/133827 oder PCT/EP07/002433 beschrieben ist. Pflanzen oder Pflanzensorten (die nach Methoden der pflanzlichen Biotechnologie, wie der Gentechnik, erhalten wurden), die ebenfalls mit den erfindungsgemäßen Verbindungen der allgemeinen Formel (I) behandelt werden können, weisen eine veränderte Menge, Qualität und/oder Lagerfähigkeit des Ernteprodukts und/oder veränderte Eigenschaften von bestimmten Bestandteilen des Ernteprodukts auf, wie zum Beispiel: 1) Transgene Pflanzen, die eine modifizierte Stärke synthetisieren, die bezüglich ihrer chemisch- physikalischen Eigenschaften, insbesondere des Amylosegehalts oder des Amylose/Amylopektin- Verhältnisses, des Verzweigungsgrads, der durchschnittlichen Kettenlänge, der Verteilung der Seitenketten, des Viskositätsverhaltens, der Gelfestigkeit, der Stärkekorngröße und/oder Stärkekornmorphologie im Vergleich mit der synthetisierten Stärke in Wildtyppflanzenzellen oder - pflanzen verändert ist, so dass sich diese modifizierte Stärke besser für bestimmte Anwendungen eignet. Diese transgenen Pflanzen, die eine modifizierte Stärke synthetisieren, sind zum Beispiel in EP0571427, WO95/004826, EP0719338, WO96/15248, WO96/19581, WO96/27674, WO97/11188, WO 97/26362, WO97/32985, WO97/42328, WO97/44472, WO97/45545, WO98/27212, WO98/40503, WO99/58688, WO99/58690, WO99/58654, WO2000/008184, WO2000/008185, WO2000/28052, WO2000/77229, WO2001/12782, WO2001/12826, WO2002/101059, WO2003/071860, WO2004/056999, WO2005/030942, WO2005/030941, WO2005/095632, WO2005/095617, WO2005/095619, WO2005/095618, WO2005/123927, WO2006/018319, WO2006/103107, WO2006/108702, WO2007/009823, WO2000/22140, WO2006/063862, WO2006/072603, WO2002/034923, EP06090134.5, EP06090228.5, EP06090227.7, EP07090007.1, EP07090009.7, WO2001/14569, WO2002/79410, WO2003/33540, WO2004/078983, WO2001/19975, WO95/26407, WO96/34968, WO98/20145, WO99/12950, WO99/66050, WO99/53072, US6,734,341, WO2000/11192, WO98/22604, WO98/32326, WO2001/98509, WO2001/98509, WO2005/002359, US5,824,790, US6,013,861, WO94/004693, WO94/009144, WO94/11520, WO95/35026 bzw. WO97/20936 beschrieben. 2) Transgene Pflanzen, die Nichtstärkekohlenhydratpolymere synthetisieren, oder Nichtstärkekohlenhydratpolymere, deren Eigenschaften im Vergleich zu Wildtyppflanzen ohne genetische Modifikation verändert sind. Beispiele sind Pflanzen, die Polyfructose, insbesondere des Inulin- und Levantyps, produzieren, wie dies in EP0663956, WO96/001904, WO96/021023, WO98/039460 und WO99/024593 beschrieben ist, Pflanzen, die alpha-1,4-Glucane produzieren, wie dies in WO95/031553, US2002/031826, US6,284,479, US5,712,107, WO97/047806, WO97/047807, WO97/047808 und WO2000/14249 beschrieben ist, Pflanzen, die alpha-1,6-verzweigte alpha-1,4- Glucane produzieren, wie dies in WO2000/73422 beschrieben ist, und Pflanzen, die Alternan produzieren, wie dies in WO2000/047727, EP06077301.7, US5,908,975 und EP0728213 beschrieben ist. 3) Transgene Pflanzen, die Hyaluronan produzieren, wie dies zum Beispiel in WO06/032538, WO2007/039314, WO2007/039315, WO2007/039316, JP2006/304779 und WO2005/012529 beschrieben ist. Pflanzen oder Pflanzensorten (die nach Methoden der pflanzlichen Biotechnologie, wie der Gentechnik, erhalten wurden), die ebenfalls mit den erfindungsgemäßen Verbindungen der allgemeinen Formel (I) behandelt werden können, sind Pflanzen wie Baumwollpflanzen mit veränderten Fasereigenschaften. Solche Pflanzen können durch genetische Transformation oder durch Selektion von Pflanzen, die eine Mutation enthalten, die solche veränderten Fasereigenschaften verleiht, erhalten werden; dazu zählen: a) Pflanzen wie Baumwollpflanzen, die eine veränderte Form von Cellulosesynthasegenen enthalten, wie dies in WO98/000549 beschrieben ist, b) Pflanzen wie Baumwollpflanzen, die eine veränderte Form von rsw2- oder rsw3-homologen Nukleinsäuren enthalten, wie dies in WO2004/053219 beschrieben ist; c) Pflanzen wie Baumwollpflanzen mit einer erhöhten Expression der Saccharosephosphatsynthase, wie dies in WO2001/017333 beschrieben ist; d) Pflanzen wie Baumwollpflanzen mit einer erhöhten Expression der Saccharosesynthase, wie dies in WO2002/45485 beschrieben ist; e) Pflanzen wie Baumwollpflanzen bei denen der Zeitpunkt der Durchlasssteuerung der Plasmodesmen an der Basis der Faserzelle verändert ist, z. B. durch Herunterregulieren der faserselektiven β-1,3-Glucanase, wie dies in WO2005/017157 beschrieben ist; f) Pflanzen wie Baumwollpflanzen mit Fasern mit veränderter Reaktivität, z. B. durch Expression des N-Acetylglucosamintransferasegens, darunter auch nodC, und von Chitinsynthasegenen, wie dies in WO2006/136351 beschrieben ist. Pflanzen oder Pflanzensorten (die nach Methoden der pflanzlichen Biotechnologie, wie der Gentechnik, erhalten wurden), die ebenfalls mit den erfindungsgemäßen Verbindungen der allgemeinen Formel (I) behandelt werden können, sind Pflanzen wie Raps oder verwandte Brassica-Pflanzen mit veränderten Eigenschaften der Ölzusammensetzung. Solche Pflanzen können durch genetische Transformation oder durch Selektion von Pflanzen, die eine Mutation enthalten, die solche veränderten Öleigenschaften verleiht, erhalten werden; dazu zählen: a) Pflanzen wie Rapspflanzen, die Öl mit einem hohen Ölsäuregehalt produzieren, wie dies zum Beispiel in US5,969,169, US5,840,946 oder US6,323,392 oder US6,063, 947 beschrieben ist; b) Pflanzen wie Rapspflanzen, die Öl mit einem niedrigen Linolensäuregehalt produzieren, wie dies in US6,270828, US6,169,190 oder US5,965,755 beschrieben ist. c) Pflanzen wie Rapspflanzen, die Öl mit einem niedrigen gesättigten Fettsäuregehalt produzieren, wie dies z. B. in US5,434,283 beschrieben ist. Besonders nützliche transgene Pflanzen, die mit den erfindungsgemäßen Verbindungen der allgemeinen Formel (I) behandelt werden können, sind Pflanzen, die Transformations-Events, oder eine Kombination von Transformations-Events, enthalten und die zum Beispiel in den Dateien von verschiedenen nationalen oder regionalen Behörden angeführt sind. Besonders nützliche transgene Pflanzen, die mit den erfindungsgemäßen Verbindungen der allgemeinen Formel (I) behandelt werden können, sind beispielhaft Pflanzen mit einem oder mehreren Genen, die für ein oder mehrere Toxine kodieren, sind die transgenen Pflanzen, die unter den folgenden Handelsbezeichnungen angeboten werden: YIELD GARD ^ (zum Beispiel Mais, Baumwolle, Sojabohnen), KnockOut ^ (zum Beispiel Mais), BiteGard ^ (zum Beispiel Mais), BT-Xtra ^ (zum Beispiel Mais), StarLink ^ (zum Beispiel Mais), Bollgard ^ (Baumwolle), Nucotn ^ (Baumwolle), Nucotn 33B ^ (Baumwolle), NatureGard ^ (zum Beispiel Mais), Protecta ^ und NewLeaf ^ (Kartoffel). Herbizidtolerante Pflanzen, die zu erwähnen sind, sind zum Beispiel Maissorten, Baumwollsorten und Sojabohnensorten, die unter den folgenden Handelsbezeichnungen angeboten werden: Roundup Ready ^ (Glyphosatetoleranz, zum Beispiel Mais, Baumwolle, Sojabohne), Liberty Link ^ (Phosphinotricintoleranz, zum Beispiel Raps), IMI ^ (Imidazolinontoleranz) und SCS ^ (Sylfonylharnstofftoleranz), zum Beispiel Mais. Zu den herbizidresistenten Pflanzen (traditionell auf Herbizidtoleranz gezüchtete Pflanzen), die zu erwähnen sind, zählen die unter der Bezeichnung Clearfield ^ angebotenen Sorten (zum Beispiel Mais). Die erfindungsgemäß zu verwendenden Verbindungen der Formel (I) können in übliche Formulierungen überführt werden, wie Lösungen, Emulsionen, Spritzpulver, wasser- und ölbasierte Suspensionen, Pulver, Stäubemittel, Pasten, lösliche Pulver, lösliche Granulate, Streugranulate, Suspensions- Emulsions-Konzentrate, Wirkstoff-imprägnierte Naturstoffe, Wirkstoff-imprägnierte synthetische Stoffe, Düngemittel sowie Feinstverkapselungen in polymeren Stoffen. Im Rahmen der vorliegenden Erfindung ist es insbesondere bevorzugt, wenn die Verbindungen der allgemeinen Formel (I) in der Form einer Sprühformulieruing verwendet werden. Die vorliegende Erfindung betrifft daher darüber hinaus auch eine Sprühformulierung zur Steigerung der Widerstandsfähigkeit von Pflanzen gegenüber abiotischem Stress. Im Folgenden wird eine Sprühformulierung näher beschrieben: Die Formulierungen zur Sprühapplikation werden in bekannter Weise hergestellt, z.B. durch Ver- mischen der zu verwendenden erfindungsgemäßen Verbindungen der allgmeinen Formel (I) mit Streckmitteln, also flüssigen Lösungsmitteln und/oder festen Trägerstoffen, gegebenenfalls unter Verwendung von oberflächenaktiven Mitteln, also Emulgiermitteln und/oder Dispergiermitteln und/oder schaumerzeugenden Mitteln. Weitere übliche Zusatzstoffe, wie zum Beispiel übliche Streckmittel sowie Lösungs- oder Verdünnungsmittel, Farbstoffe, Netzmittel, Dispergiermittel, Emulgatoren, Entschäumer, Konservierungsmittel, sekundäre Verdickungsmittel, Kleber, Gibberelline und auch Wasser, können gegebenenfalls auch verwendet werden. Die Herstellung der Formulierungen erfolgt entweder in geeigneten Anlagen oder auch vor oder während der Anwendung. Als Hilfsstoffe können solche Stoffe Verwendung finden, die geeignet sind, dem Mittel selbst oder und/oder davon abgeleitete Zubereitungen (z.B. Spritzbrühen) besondere Eigenschaften zu verleihen, wie bestimmte technische Eigenschaften und/oder auch besondere biologische Eigenschaften. Als typische Hilfsmittel kommen in Frage: Streckmittel, Lösemittel und Trägerstoffe. Als Streckmittel eignen sich z.B. Wasser, polare und unpolare organische chemische Flüssigkeiten z.B. aus den Klassen der aromatischen und nicht-aromatischen Kohlenwasserstoffe (wie Paraffine, Alkylbenzole, Alkylnaphthaline, Chlorbenzole), der Alkohole und Polyole (die ggf. auch substituiert, verethert und/oder verestert sein können), der Ketone (wie Aceton, Cyclohexanon), Ester (auch Fette und Öle) und (Poly-)Ether, der einfachen und substituierten Amine, Amide, Lactame (wie N- Alkylpyrrolidone) und Lactone, der Sulfone und Sulfoxide (wie Dimethylsysulfoxid). Im Falle der Benutzung von Wasser als Streckmittel können z.B. auch organische Lösemittel als Hilfslösungsmittel verwendet werden. Als flüssige Lösemittel kommen im wesentlichen in Frage: Aromaten, wie Xylol, Toluol, oder Alkylnaphthaline, chlorierte Aromaten und chlorierte aliphatische Kohlenwasserstoffe, wie Chlorbenzole, Chlorethylene oder Methylenchlorid, aliphatische Kohlen- wasserstoffe, wie Cyclohexan oder Paraffine, z.B. Erdölfraktionen, mineralische und pflanzliche Öle, Alkohole, wie Butanol oder Glykol sowie deren Ether und Ester, Ketone wie Aceton, Methylethylketon, Methylisobutylketon oder Cyclohexanon, stark polare Lösungsmittel, wie Dimethylsulfoxid, sowie Wasser. Es können Farbstoffe wie anorganische Pigmente, z.B. Eisenoxid, Titanoxid, Ferrocyanblau und organische Farbstoffe, wie Alizarin-, Azo- und Metallphthalocyaninfarbstoffe und Spurennährstoffe wie Salze von Eisen, Mangan, Bor, Kupfer, Kobalt, Molybdän und Zink verwendet werden. Als Netzmittel, die in den erfindungsgemäß verwendbaren Formulierungen enthalten sein können, kommen alle zur Formulierung von agrochemischen Wirkstoffen üblichen, die Benetzung fördernden Stoffe in Frage. Vorzugsweise verwendbar sind Alkylnaphthalin-Sulfonate, wie Diisopropyl- oder Diisobutylnaphthalin-Sulfonate. Als Dispergiermittel und/oder Emulgatoren, die in den erfindungsgemäß verwendbaren Formulierungen enthalten sein können, kommen alle zur Formulierung von agrochemischen Wirkstoffen üblichen nichtionischen, anionischen und kationischen Dispergiermittel in Betracht. Vorzugsweise verwendbar sind nichtionische oder anionische Dispergiermittel oder Gemische von nichtionischen oder anionischen Dispergiermitteln. Als geeignete nichtionische Dispergiermittel sind insbesondere Ethylenoxid- Propylenoxid-Blockpolymere, Alkylphenolpolyglykolether sowie Tristryrylphenolpolyglykolether und deren phosphatierte oder sulfatierte Derivate zu nennen. Geeignete anionische Dispergiermittel sind insbesondere Ligninsulfonate, Polyacrylsäuresalze und Arylsulfonat-Formaldehydkondensate. Als Entschäumer können in den erfindungsgemäß verwendbaren Formulierungen alle zur Formulierung von agrochemischen Wirkstoffen üblichen schaumhemmenden Stoffe enthalten sein. Vorzugsweise verwendbar sind Silikonentschäumer und Magnesiumstearat. Als Konservierungsmittel können in den erfindungsgemäß verwendbaren Formulierungen alle für derartige Zwecke in agrochemischen Mitteln einsetzbaren Stoffe vorhanden sein. Beispielhaft genannt seien Dichlorphen und Benzylalkoholhemiformal. Als sekundäre Verdickungsmittel, die in den erfindungsgemäß verwendbaren Formulierungen enthalten sein können, kommen alle für derartige Zwecke in agrochemischen Mitteln einsetzbaren Stoffe in Frage. Vorzugsweise in Betracht kommen Cellulosederivate, Acrylsäurederivate, Xanthan, modifizierte Tone und hochdisperse Kieselsäure. Als Kleber, die in den erfindungsgemäß verwendbaren Formulierungen enthalten sein können, kommen alle üblichen in Beizmitteln einsetzbaren Bindemittel in Frage. Vorzugsweise genannt seien Polyvinylpyrrolidon, Polyvinylacetat, Polyvinylalkohol und Tylose. Als Gibberelline, die in den erfindungsgemäß verwendbaren Formulierungen enthalten sein können, kommen vorzugsweise die Gibberelline A1, A3 (= Gibberellinsäure), A4 und A7 infrage, besonders bevorzugt verwendet man die Gibberellinsäure. Die Gibberelline sind bekannt (vgl. R. Wegler „Chemie der Pflanzenschutz- und Schädlingsbekämpfungsmittel“, Bd.2, Springer Verlag, 1970, S.401-412). Weitere Additive können Duftstoffe, mineralische oder vegetabilische gegebenenfalls modifizierte Öle, Wachse und Nährstoffe (auch Spurennährstoffe), wie Salze von Eisen, Mangan, Bor, Kupfer, Kobalt, Molybdän und Zink sein. Weiterhin enthalten sein können Stabilisatoren wie Kältestabilisatoren, Oxidationsschutzmittel, Lichtschutzmittel oder andere die chemische und / oder physikalische Stabilität verbessernde Mittel. Die Formulierungen enthalten im Allgemeinen zwischen 0,01 und 98 Gew.-%, vorzugsweise zwischen 0,5 und 90 GEw. %, der Verbindung der allgemeinen Formel (I). Die erfindungsgemäßen Verbindungen der allgemeinen Formel (I) können in handelsüblichen Formulierungen sowie in den aus diesen Formulierungen bereiteten Anwendungsformen in Mischung mit anderen Wirkstoffen wie Insektiziden, Lockstoffen, Sterilantien, Bakteriziden, Akariziden, Nematiziden, Fungiziden, wachstumsregulierenden Stoffen, Herbiziden, Safenern, Düngemitteln oder Semiochemicals vorliegen. Ferner lässt sich die beschriebene positive Wirkung der Verbindungen der Formel (I) auf die pflanzeneigenen Abwehrkräfte durch eine zusätzliche Behandlung mit insektziden, fungiziden oder bakteriziden Wirkstoffen unterstützen. Bevorzugte Zeitpunkte für die Applikation der erfindungsgemäßen Verbindungen der allgemeinen Formel (I) oder deren Salze zur Steigerung der Resistenz gegenüber abiotischem Stress sind Boden-, Stamm- und/oder Blattbehandlungen mit den zugelassenen Aufwandmengen. Die erfindungsgemäßen Verbindungen der allgemeinen Formel (I) oder deren Salze können im Allgemeinen darüber hinaus in ihren handelsüblichen Formulierungen sowie in den aus diesen Formulierungen bereiteten Anwendungsformen in Mischungen mit anderen Wirkstoffen, wie Insektiziden, Lockstoffen, Sterilantien, Akariziden, Nematiziden, Fungiziden, Bakteriziden, wachstumsregulierenden Stoffen, die Pflanzenreife beeinflussenden Stoffen, Safenern oder Herbiziden vorliegen. Die Wirkstoffe der allgemeinen Formel (I) können im Allgemeinen darüber hinaus in ihren handelsüblichen Formulierungen sowie in den aus diesen Formulierungen bereiteten Anwendungsformen in Mischungen mit anderen Wirkstoffen, wie Insektiziden, Lockstoffen, Sterilantien, Akariziden, Nematiziden, Fungiziden, Bakteriziden, wachstumsregulierenden Stoffen, die Pflanzenreife beeinflussenden Stoffen, Safenern oder Herbiziden vorliegen. Besonders günstige Mischpartner sind beispielsweise die nachfolgend gruppenweise genannten Wirkstoffe der verschiedenen Klassen, ohne dass durch deren Reihenfolge eine Präferenz gesetzt wird: Fungizide: F1) Inhibitoren der Nucleinsäure Synthese, z. B. Benalaxyl, Benalaxyl-M, Bupirimat, Chiralaxyl, Clozylacon, Dimethirimol, Ethirimol, Furalaxyl, Hymexazol, Metalaxyl, Metalaxyl-M, Ofurace, Oxadixyl, Oxolinsäure; F2) Inhibitoren der Mitose und Zellteilung, z. B. Benomyl, Carbendazim, Diethofencarb, Fuberidazole, Fluopicolid, Pencycuron, Thiabendazol, Thiophanat-methyl, Zoxamid und Chlor-7-(4-methylpiperidin- 1-yl)-6-(2,4,6- Trifluorphenyl [1,2,4]triazolo[1,5-a]pyrimidin; F3) Inhibitoren der Atmungskette Komplex I / II, z. B. Diflumetorim, Bixafen, Boscalid, Carboxin, Diflumethorim Fenfuram, Fluopyram, Flutolanil, Furametpyr, Mepronil, Oxycarboxin, Penflufen, Penthiopyrad, Thifluzamid, N-[2-(1,3-Dimethylbutyl)phenyl]-5-fluor-1,3-dimethyl-1H-pyra zol-4- carboxamid, Isopyrazam, Sedaxan, 3-(Difluormethyl)-1-methyl-N-(3',4',5'-trifluorbiphenyl-2-yl )-1H- pyrazol-4-carboxamid, 3-(Difluormethyl)-1-methyl-N-[2-(1,1,2,2-tetrafluorethoxy)ph enyl]-1H-pyrazol- 4-carboxamid, 3-(Difluormethyl)-N-[4-fluor-2-(1,1,2,3,3,3-hexafluorpropoxy )phenyl]-1-methyl-1H- pyrazol-4-carboxamid, N-[1-(2,4-Dichlorphenyl)-1-methoxypropan-2-yl]-3-(difluormet hyl)-1-methyl- 1H-pyrazol-4-carboxamid und entsprechende Salze; F4) Inhibitoren der Atmungskette Komplex III, z. B.Amisulbrom, Azoxystrobin, Cyazofamid, Dimoxystrobin, Enestrobin, Famoxadon, Fenamidon, Fluoxastrobin, Kresoximmethyl, Metominostrobin, Orysastrobin, Pyraclostrobin, Pyribencarb, Picoxystrobin, Trifloxystrobin, (2E)-2-(2- {[6-(3-Chlor-2-methylphenoxy)-5-fluorpyrimidin-4-yl]oxy}phen yl)-2-(methoxyimino)-N- methylethanamid, (2E)-2-(Ethoxyimino)-N-methyl-2-(2-{[({(1E)-1-[3-(trifluorme thyl)- phenyl]ethyliden}amino)oxy]methyl}phenyl)ethanamid und entsprechende Salze, (2E)-2- (Methoxyimino)-N-methyl-2-{2-[(E)-({1-[3-(trifluormethyl)phe nyl]ethoxy}- imino)methyl]phenyl}ethanamid, (2E)-2-{2-[({[(1E)-1-(3-{[(E)-1-Fluor-2-phenylethenyl]- oxy}phenyl)ethyliden]amino}oxy)methyl]phenyl}-2-(methoxyimin o)-N-methylethanamid, (2E)-2-{2- [({[(2E,3E)-4-(2,6-Dichlorphenyl)but-3-en-2-yliden]amino}oxy )methyl]phenyl}-2-(methoxyimino)-N- methylethanamid, 2-Chlor-N-(1,1,3-trimethyl-2,3-dihydro-1H-inden-4-yl)pyridin -3-carboxamid, 5- Methoxy-2-methyl-4-(2-{[({(1E)-1-[3-(trifluormethyl)phenyl]e thyliden}amino)oxy]methyl}phenyl)- 2,4-dihydro-3H-1,2,4-triazol-3-on, 2-Methyl-{2-[({cyclopropyl[(4-methoxyphenyl)- imino]methyl}sulfanyl)methyl]phenyl}-3-methoxyacrylat, N-(3-Ethyl-3,5,5-trimethylcyclohexyl)-3- (formylamino)-2-hydroxybenzamid und entsprechende Salze; F5) Entkoppler, z. B. Dinocap, Fluazinam; F6) Inhibitoren der ATP Produktion, z. B. Fentinacetat, Fentinchlorid, Fentinhydroxid, Silthiofam F7) Inhibitoren der Aminosäure- und Proteinbiosynthese, z.B. Andoprim, Blasticidin-S, Cyprodinil, Kasugamycin, Kasugamycinhydrochlorid Hydrat, Mepanipyrim, Pyrimethanil F8) Inhibitoren der Signal-Transduktion, z. B. Fenpiclonil, Fludioxonil, Quinoxyfen F9) Inhibitoren der Fett- und Membran Synthese, z. B. Chlozolinat, Iprodion, Procymidon, Vinclozolin, Ampropylfos, Kalium-Ampropylfos, Edifenphos, Iprobenfos (IBP), Isoprothiolan, Pyrazophos, Tolclofos-methyl, Biphenyl, Iodocarb, Propamocarb, Propamocarb hydrochlorid F10) Inhibitoren der Ergosterol Biosynthese, z. B. Fenhexamid, Azaconazol, Bitertanol, Bromuconazol, Diclobutrazol, Difenoconazol, Diniconazol, Diniconazol-M, Etaconazol, Fenbuconazol, Fluquinconazol, Flusilazol, Flutriafol, Furconazol, Furconazol-cis, Hexaconazol, Imibenconazol, Ipconazol, Metconazol, Myclobutanil, Paclobutrazol, Penconazol, Propiconazol, Prothioconazol, Simeconazol, Spiroxamin, Tebuconazol, Triadimefon, Triadimenol, Triticonazol, Uniconazol, Voriconazol, Imazalil, Imazalilsulfat, Oxpoconazol, Fenarimol, Flurprimidol, Nuarimol, Pyrifenox, Triforin, Pefurazoat, Prochloraz, Triflumizol, Viniconazol, Aldimorph, Dodemorph, Dodemorphacetat, Fenpropimorph, Tridemorph, Fenpropidin, Naftifin, Pyributicarb, Terbinafin, 1-(4-Chlorphenyl)-2-(1H- 1,2,4-triazol-1-yl)cycloheptanol, Methyl-1-(2,2-dimethyl-2,3-dihydro-1H-inden-1-yl)-1H-imidazo l-5- carboxylat, N'-{5-(Difluormethyl)-2-methyl-4-[3-(trimethyl-silyl)propoxy ]phenyl}-N-ethyl-N- methylimidoformamid, N-Ethyl-N-methyl-N'-{2-methyl-5-(trifluormethyl)-4-[3- (trimethylsilyl)propoxy]phenyl}imidoformamid und O-{1-[(4-Methoxy-phenoxy)methyl]-2,2- dimethylpropyl}-1H-imidazol-1-carbothioat; F11) Inhibitoren der Zellwand Synthese, z. B. Benthiavalicarb, Bialaphos, Dimethomorph, Flumorph, Iprovalicarb, Polyoxins, Polyoxorim, Validamycin A F12) Inhibitoren der Melanin Biosynthese, z. B. Capropamid, Diclocymet, Fenoxanil, Phtalid, Pyroquilon, Tricyclazol F13) Resistenzinduktion, z. B. Acibenzolar-S-methyl, Probenazol, Tiadinil F14) Multisite, z. B. Captafol, Captan, Chlorthalonil, Kupfersalze wie: Kupferhydroxid, Kupfernaphthenat, Kupferoxychlorid, Kupfersulfat, Kupferoxid, Oxin-Kupfer und Bordeaux Mischung, Dichlofluanid, Dithianon, Dodin, Dodin freie Base, Ferbam, Folpet, Fluorfolpet, Guazatin, Guazatinacetat, Iminoctadin, Iminoctadinalbesilat, Iminoctadintriacetat, Mankupfer, Mancozeb, Maneb, Metiram, Metiram Zink, Propineb, Schwefel und Schwefelpräparate enthaltend Calciumpolysulphid, Thiram, Tolylfluanid, Zineb, Ziram F15) Unbekannter Mechanismus, z. B. Amibromdol, Benthiazol, Bethoxazin, Capsimycin, Carvon, Chinomethionat, Chlorpicrin, Cufraneb, Cyflufenamid, Cymoxanil, Dazomet, Debacarb, Diclomezine, Dichlorphen, Dicloran, Difenzoquat, Difenzoquat Methylsulphat, Diphenylamin, Ethaboxam, Ferimzon, flumetover, Flusulfamid, Fluopicolid, Fluorimid, Fosatyl-Al, Hexachlorbenzol, 8-Hydroxy- chinolinsulfat, Iprodione, Irumamycin, Isotianil, Methasulphocarb, Metrafenon, Methyl Isothiocyanat, Mildiomycin, Natamycin, Nickel dimethyldithiocarbamat, Nitrothal-isopropyl, Octhilinon, Oxamocarb, Oxyfenthiin, Pentachlorphenol und Salze, 2-Phenylphenol und Salze, Piperalin, Propanosin –Natrium, Proquinazid, Pyrrolnitrin, Quintozen, Tecloftalam, Tecnazen, Triazoxid, Trichlamid, Zarilamid und 2,3,5,6-Tetrachlor-4-(methylsulfonyl)-pyridin, N-(4-Chlor-2-nitrophenyl)-N-ethyl-4-methyl- benzenesulfonamid, 2-Amino-4-methyl-N-phenyl-5-thiazolecarboxamid, 2-Chlor-N-(2,3-dihydro-1,1,3- trimethyl-1H-inden-4-yl)-3-pyridincarboxamid, 3-[5-(4-Chlorphenyl)-2,3-dimethylisoxazolidin-3- yl]pyridin, cis-1-(4-Chlorphenyl)-2-(1H-1,2,4-triazol-1-yl)-cycloheptano l, 2,4-Dihydro-5-methoxy-2- methyl-4-[[[[1-[3-(trifluormethyl)-phenyl]-ethyliden]-amino] -oxy]-methyl]-phenyl]-3H-1,2,3-triazol-3- on (185336-79-2), Methyl 1-(2,3-dihydro-2,2-dimethyl-1H-inden-1-yl)-1H-imidazole-5-ca rboxylat, 3,4,5-Trichlor-2,6-pyridindicarbonitril, Methyl 2-[[[cyclopropyl[(4-methoxyphenyl) imino]methyl]thio]methyl]-.alpha.-(methoxymethylen)- benzacetat, 4-Chlor-alpha-propinyloxy-N-[2-[3- methoxy-4-(2-propinyloxy)phenyl]ethyl]-benzacetamide, (2S)-N-[2-[4-[[3-(4-chlorphenyl)-2- propinyl]oxy]-3-methoxyphenyl]ethyl]-3-methyl-2-[(methylsulf onyl)amino]-butanamid, 5-Chlor-7-(4- methylpiperidin-1-yl)-6-(2,4,6-trifluorphenyl)[1,2,4]triazol o[1,5-a]pyrimidin, 5-Chlor-6-(2,4,6- trifluorphenyl)-N-[(1R)-1,2,2-trimethylpropyl][1,2,4]triazol o[1,5-a]pyrimidin-7-amin, 5-Chlor-N-[(1R)- 1,2-dimethylpropyl]-6-(2,4,6-trifluorphenyl) [1,2,4]triazolo[1,5-a]pyrimidin-7-amine, N-[1-(5-Brom-3- chlorpyridin-2-yl)ethyl]-2,4-dichlornicotinamid, N-(5-Brom-3-chlorpyridin-2-yl)methyl-2,4-dichlor- nicotinamid, 2-Butoxy-6-iod-3-propyl-benzopyranon-4-on, N-{(Z)-[(cyclopropylmethoxy) imino][6- (difluormethoxy)-2,3-difluorphenyl]methyl}-2-benzacetamid, N-(3-Ethyl-3,5,5-trimethyl-cyclohexyl)-3- formylamino-2-hydroxy-benzamid, 2-[[[[1-[3(1Fluor-2-phenylethyl)oxy] phenyl] ethyliden]amino]oxy]methyl]-alpha-(methoxyimino)-N-methyl-al phaE-benzacetamid, N-{2-[3-Chlor-5- (trifluormethyl)pyridin-2-yl]ethyl}-2-(trifluormethyl)benzam id, N-(3',4'-dichlor-5-fluorbiphenyl-2-yl)-3- (difluormethyl)-1-methyl-1H-pyrazol-4-carboxamid, N-(6-Methoxy-3-pyridinyl)-cyclopropan carboxamid, 1-[(4-Methoxyphenoxy)methyl]-2,2-dimethylpropyl-1H-imidazol- 1- carbonsäure, O-[1-[(4- Methoxyphenoxy)methyl]-2,2-dimethylpropyl]-1H-imidazol- 1- carbothioic acid, 2-(2-{[6-(3-Chlor-2- methylphenoxy)-5-fluorpyrimidin-4-yl]oxy}phenyl)-2-(methoxyi mino)-N-methylacetamid Bakterizide: Bronopol, Dichlorphen, Nitrapyrin, Nickel-Dimethyldithiocarbamat, Kasugamycin, Octhilinon, Furancarbonsäure, Oxytetracyclin, Probenazol, Streptomycin, Tecloftalam, Kupfersulfat und andere Kupfer-Zubereitungen. Insektizide / Akarizide / Nematizide: Die hier mit ihrem „common name“ genannten Wirkstoffe sind bekannt und beispielsweise im Pestizidhandbuch („The Pesticide Manual“ 14th Ed., British Crop Protection Council 2006) beschrieben oder im Internet recherchierbar (z.B. http://www.alanwood.net/pesticides). (1) Acetylcholinesterase (AChE) Inhibitoren, wie beispielsweise Carbamate, z.B. Alanycarb, Aldicarb, Bendiocarb, Benfuracarb, Butocarboxim, Butoxycarboxim, Carbaryl, Carbofuran, Carbosulfan, Ethiofencarb, Fenobucarb, Formetanate, Furathiocarb, Isoprocarb, Methiocarb, Methomyl, Metolcarb, Oxamyl, Pirimicarb, Propoxur, Thiodicarb, Thiofanox, Triazamate, Trimethacarb, XMC und Xylylcarb oder organophosphate, z.B. Acephate, Azamethiphos, Azinphos-ethyl, Azinphos-methyl, Cadusafos, Chlorethoxyfos, Chlorfenvinphos, Chlormephos, Chlorpyrifos, Chlorpyrifos-methyl, Coumaphos, Cyanophos, Demeton-S-methyl, Diazinon, Dichlorvos/DDVP, Dicrotophos, Dimethoate, Dimethylvinphos, Disulfoton, EPN, Ethion, Ethoprophos, Famphur, Fenamiphos, Fenitrothion, Fenthion, Fosthiazate, Heptenophos, Imicyafos, Isofenphos, Isopropyl O-(methoxyaminothio- phosphoryl) salicylat, Isoxathion, Malathion, Mecarbam, Methamidophos, Methidathion, Mevinphos, Monocrotophos, Naled, Omethoate, Oxydemeton-methyl, Parathion, Parathion-methyl, Phenthoate, Phorate, Phosalone, Phosmet, Phosphamidon, Phoxim, Pirimiphos-methyl, Profenofos, Propetamphos, Prothiofos, Pyraclofos, Pyridaphenthion, Quinalphos, Sulfotep, Tebupirimfos, Temephos, Terbufos, Tetrachlorvinphos, Thiometon, Triazophos, Triclorfon und Vamidothion. (2) GABA-gesteuerte Chlorid-Kanal-Antagonisten, wie beispielsweise Cyclodien-organochlorine, z.B. Chlordane und Endosulfan oder Phenylpyrazole (Fiprole), z.B. Ethiprole und Fipronil. (3) Natrium-Kanal-Modulatoren / Spannungsabhängige Natrium-Kanal-Blocker, wie beispielsweise Pyrethroide, z.B. Acrinathrin, Allethrin, d-cis-trans Allethrin, d-trans Allethrin, Bifenthrin, Bioallethrin, Bioallethrin S-cyclopentenyl Isomer, Bioresmethrin, Cycloprothrin, Cyfluthrin, beta-Cyfluthrin, Cyhalothrin, lambda-Cyhalothrin, gamma-Cyhalothrin, Cypermethrin, alpha-Cypermethrin, beta- Cypermethrin, theta-Cypermethrin, zeta-Cypermethrin, Cyphenothrin [(1R)-trans-Isomere], Deltamethrin, Empenthrin [(EZ)-(1R)-Isomere), Esfenvalerate, Etofenprox, Fenpropathrin, Fenvalerate, Flucythrinate, Flumethrin, tau-Fluvalinate, Halfenprox, Imiprothrin, Kadethrin, Momfluorthrin, Permethrin, Phenothrin [(1R)-trans-Isomer), Prallethrin, Pyrethrine (pyrethrum), Resmethrin, Silafluofen, Tefluthrin, Tetramethrin, Tetramethrin [(1R)- Isomere)], Tralomethrin und Transfluthrin oder DDT oder Methoxychlor. (4) Nikotinerge Acetylcholin-Rezeptor (nAChR) Agonisten, wie beispielsweise Neonikotinoide, z.B. Acetamiprid, Clothianidin, Dinotefuran, Imidacloprid, Nitenpyram, Thiacloprid und Thiamethoxam oder Nikotin oder Sulfoxaflor oder Flupyradifurone. (5) Nikotinerge Acetylcholin-Rezeptor (nAChR) allosterische Aktivatoren, wie beispielsweise Spinosine, z.B. Spinetoram und Spinosad. (6) Chlorid-Kanal-Aktivatoren, wie beispielsweise Avermectine/Milbemycine, z.B. Abamectin, Emamectin-benzoat, Lepimectin und Milbemectin. (7) Juvenilhormon-Imitatoren, wie beispielsweise Juvenilhormon-Analoge, z.B. Hydroprene, Kinoprene und Methoprene oder Fenoxycarb oder Pyriproxyfen. (8) Wirkstoffe mit unbekannten oder nicht spezifischen Wirkmechanismen, wie beispielsweise Alkylhalide, z.B. Methylbromid und andere Alkylhalide; oderChlorpicrin oder Sulfurylfluorid oder Borax oder Brechweinstein. (9) Selektive Fraßhemmer, z.B. Pymetrozine oder Flonicamid. (10) Milbenwachstumsinhibitoren, z.B. Clofentezine, Hexythiazox und Diflovidazin oder Etoxazole. (11) Mikrobielle Disruptoren der Insektendarmmembran, z.B. Bacillus thuringiensis Subspezies israelensis, Bacillus sphaericus, Bacillus thuringiensis Subspezies aizawai, Bacillus thuringiensis Subspezies kurstaki, Bacillus thuringiensis Subspezies tenebrionis und BT Pflanzenproteine: Cry1Ab, Cry1Ac, Cry1Fa, Cry2Ab, mCry3A, Cry3Ab, Cry3Bb, Cry34/35Ab1. (12) Inhibitoren der oxidativen Phosphorylierung, ATP-Disruptoren, wie beispielsweise Diafenthiuron oder organozinnverbindungen, z.B. Azocyclotin, Cyhexatin und Fenbutatin-oxid oder Propargite oder Tetradifon. (13) Entkoppler der oxidativen Phoshorylierung durch Unterbrechung des H-Protongradienten, wie beispielsweise Chlorfenapyr, DNOC und Sulfluramid. (14) Nikotinerge Acetylcholin-Rezeptor-Antagonisten, wie beispielsweise Bensultap, Cartap- hydrochlorid, Thiocyclam und Thiosultap-Natrium. (15) Inhibitoren der Chitinbiosynthese, Typ 0, wie beispielsweise Bistrifluron, Chlorfluazuron, Diflubenzuron, Flucycloxuron, Flufenoxuron, Hexaflumuron, Lufenuron, Novaluron, Noviflumuron, Teflubenzuron und Triflumuron. (16) Inhibitoren der Chitinbiosynthese, Typ 1, wie beispielsweise Buprofezin. (17) Häutungsstörende Wirkstoffe, Dipteran, wie beispielsweise Cyromazine. (18) Ecdyson-Rezeptor Agonisten, wie beispielsweise Chromafenozide, Halofenozide, Methoxyfenozide und Tebufenozide. (19) Oktopaminerge Agonisten, wie beispielsweise Amitraz. (20) Komplex-III-Elektronentransportinhibitoren, wie beispielsweise Hydramethylnon oder Acequinocyl oder Fluacrypyrim. (21) Komplex-I-Elektronentransportinhibitoren, beispielsweise METI-Akarizide, z.B. Fenazaquin, Fenpyroximate, Pyrimidifen, Pyridaben, Tebufenpyrad und Tolfenpyrad oder Rotenone (Derris). (22) Spannungsabhängige Natriumkanal-Blocker, z.B. Indoxacarb oder Metaflumizone. (23) Inhibitoren der Acetyl-CoA-Carboxylase, wie beispielsweise Tetron- und Tetramsäurederivate, z.B. Spirobudiclofen, Spirodiclofen, Spiromesifen und Spirotetramat. (24) Komplex-IV-Elektronentransportinhibitoren, wie beispielsweise Phosphine, z.B. Aluminiumphosphid, Calciumphosphid, Phosphin und Zinkphosphid oder Cyanid. (25) Komplex-II-Elektronentransportinhibitoren, wie beispielsweise Cyenopyrafen und Cyflumetofen. (28) Ryanodinrezeptor-Effektoren, wie beispielsweise Diamide, z.B. Chlorantraniliprole, Cyantraniliprole, Flubendiamide und Tetrachlorantraniliprole. Weitere Wirkstoffe mit unbekanntem oder nicht eindeutigem Wirkmechanismus, wie beispielsweise Afidopyropen, Afoxolaner, Azadirachtin, Benclothiaz, Benzoximate, Bifenazate, Broflanilide, Bromopropylate, Chinomethionat, Cryolite, Cyclaniliprole, Cycloxaprid, Cyhalodiamide Dicloromezotiaz, Dicofol, Diflovidazin, Flometoquin, Fluazaindolizine, Fluensulfone, Flufenerim, Flufenoxystrobin, Flufiprole, Fluhexafon, Fluopyram, Fluralaner, Fluxametamide, Fufenozide, Guadipyr, Heptafluthrin, Imidaclothiz, Iprodione, Lotilaner, Meperfluthrin, Paichongding, Pyflubumide, Pyridalyl, Pyrifluquinazon, Pyriminostrobin, Sarolaner, Tetramethylfluthrin, Tetraniliprole, Tetrachlorantraniliprole, Tioxazafen, Thiofluoximate, Triflumezopyrim und Iodmethane; des weiteren Präparate auf Basis von Bacillus firmus (I-1582, BioNeem, Votivo) , sowie folgende bekannte wirksame Verbindungen: 1-{2-Fluor-4-methyl-5-[(2,2,2-trifluorethyl)sulfinyl]phenyl} -3-(trifluormethyl)-1H- 1,2,4-triazol-5-amin (bekannt aus WO2006/043635), {1'-[(2E)-3-(4-Chlorphenyl)prop-2-en-1-yl]-5- fluorspiro[indol-3,4'-piperidin]-1(2H)-yl}(2-chlorpyridin-4- yl)methanon (bekannt aus WO2003/106457), 2-Chlor-N-[2-{1-[(2E)-3-(4-chlorphenyl)prop-2-en-1-yl]piperi din-4-yl}-4- (trifluormethyl)phenyl]isonicotinamid (bekannt aus WO2006/003494), 3-(2,5-Dimethylphenyl)-4- hydroxy-8-methoxy-1,8-diazaspiro[4.5]dec-3-en-2-on (bekannt aus WO2009/049851), 3-(2,5- Dimethylphenyl)-8-methoxy-2-oxo-1,8-diazaspiro[4.5]dec-3-en- 4-yl-ethylcarbonat (bekannt aus WO2009/049851), 4-(But-2-in-1-yloxy)-6-(3,5-dimethylpiperidin-1-yl)-5-fluorp yrimidin (bekannt aus WO2004/099160), 4-(But-2-in-1-yloxy)-6-(3-chlorphenyl)pyrimidin (bekannt aus WO2003/076415), PF1364 (CAS-Reg.No.1204776-60-2), Methyl-2-[2-({[3-brom-1-(3-chlorpyridin-2-yl)-1H-pyrazol-5- yl]carbonyl}amino)-5-chlor-3-methylbenzoyl]-2-methylhydrazin carboxylat (bekannt aus WO2005/085216), Methyl-2-[2-({[3-brom-1-(3-chlorpyridin-2-yl)-1H-pyrazol-5-y l]carbonyl}amino)-5- cyan-3-methylbenzoyl]-2-ethylhydrazincarboxylat (bekannt aus WO2005/085216), Methyl-2-[2-({[3- brom-1-(3-chlorpyridin-2-yl)-1H-pyrazol-5-yl]carbonyl}amino) -5-cyan-3-methylbenzoyl]-2- methylhydrazincarboxylat (bekannt aus WO2005/085216), Methyl-2-[3,5-dibrom-2-({[3-brom-1-(3- chlorpyridin-2-yl)-1H-pyrazol-5-yl]carbonyl}amino)benzoyl]-2 -ethylhydrazincarboxylat (bekannt aus WO2005/085216), N-[2-(5-Amino-1,3,4-thiadiazol-2-yl)-4-chlor-6-methylphenyl] -3-brom-1-(3- chlorpyridin-2-yl)-1H-pyrazol-5-carboxamid (bekannt aus CN102057925), 4-[5-(3,5-Dichlorphenyl)-5- (trifluormethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methyl-N-(1- oxidothietan-3-yl)benzamid (bekannt aus WO2009/080250), N-[(2E)-1-[(6-Chlorpyridin-3-yl)methyl]pyridin-2(1H)-yliden] -2,2,2- trifluoracetamid (bekannt aus WO2012/029672), 1-[(2-Chlor-1,3-thiazol-5-yl)methyl]-4-oxo-3-phenyl- 4H-pyrido[1,2-a]pyrimidin-1-ium-2-olat (bekannt aus WO2009/099929), 1-[(6-Chlorpyridin-3- yl)methyl]-4-oxo-3-phenyl-4H-pyrido[1,2-a]pyrimidin-1-ium-2- olat (bekannt aus WO2009/099929), 4- (3-{2,6-Dichlor-4-[(3,3-dichlorprop-2-en-1-yl)oxy]phenoxy}pr opoxy)-2-methoxy-6- (trifluormethyl)pyrimidin (bekannt aus CN101337940), N-[2-(tert-Butylcarbamoyl)-4-chlor-6- methylphenyl]-1-(3-chlorpyridin-2-yl)-3-(fluormethoxy)-1H-py razol-5-carboxamid (bekannt aus WO2008/134969), Butyl-[2-(2,4-dichlorphenyl)-3-oxo-4-oxaspiro[4.5]dec-1-en-1 -yl]-carbonat (bekannt aus CN 102060818), 3E)-3-[1-[(6-Chlor-3-pyridyl)methyl]-2-pyridyliden]-1,1,1-tr ifluor-propan-2-on (bekannt aus WO2013/144213), N-(Methylsulfonyl)-6-[2-(pyridin-3-yl)-1,3-thiazol-5-yl]pyri din-2- carboxamid (bekannt aus WO2012/000896), N-[3-(Benzylcarbamoyl)-4-chlorphenyl]-1-methyl-3- (pentafluorethyl)-4-(trifluormethyl)-1H-pyrazol-5-carboxamid (bekannt aus WO2010/051926), 5-Brom- 4-chlor-N-[4-chlor-2-methyl-6-(methylcarbamoyl)phenyl]-2-(3- chlor-2-pyridyl)pyrazole-3-carboxamid (bekannt aus CN103232431), Tioxazafen, 4-[5-(3,5-Dichlorphenyl)-4,5-dihydro-5-(trifluormethyl)-3- isoxazolyl]-2-methyl-N-(cis-1-oxido-3-thietanyl)-benzamid, 4-[5-(3,5-Dichlorphenyl)-4,5-dihydro-5- (trifluormethyl)-3-isoxazolyl]-2-methyl-N-(trans-1-oxido-3-t hietanyl)-benzamid und 4-[(5S)-5-(3,5- Dichlorphenyl)-4,5-dihydro-5-(trifluormethyl)-3-isoxazolyl]- 2-methyl-N-(cis-1-oxido-3-thietanyl) benzamid (bekannt aus WO 2013050317 A1), N-[3-Chlor-1-(3-pyridinyl)-1H-pyrazol-4-yl]-N-ethyl-3- [(3,3,3-trifluorpropyl)sulfinyl]-propanamid, (+)-N-[3-Chlor-1-(3-pyridinyl)-1H-pyrazol-4-yl]-N-ethyl- 3-[(3,3,3-trifluorpropyl)sulfinyl]-propanamid und (-)-N-[3-Chlor-1-(3-pyridinyl)-1H-pyrazol-4-yl]-N- ethyl-3-[(3,3,3-trifluorpropyl)sulfinyl]-propanamid (bekannt aus WO 2013162715 A2, WO 2013162716 A2, US 20140213448 A1), 5-[[(2E)-3-Chlor-2-propen-1-yl]amino]-1-[2,6-dichlor-4- (trifluormethyl)phenyl]-4-[(trifluormethyl)sulfinyl]-1H-pyra zol-3-carbonitril (bekannt aus CN 101337937 A), 3-Brom-N-[4-chlor-2-methyl-6-[(methylamino)thioxomethyl]phen yl]-1-(3-chlor-2- pyridinyl)-1H-pyrazol-5-carboxamid, (Liudaibenjiaxuanan, bekannt aus CN 103109816 A); N-[4- Chlor-2-[[(1,1-dimethylethyl)amino]carbonyl]-6-methylphenyl] -1-(3-chlor-2-pyridinyl)-3- (fluormethoxy)-1H-pyrazol-5-carboxamid (bekannt aus WO 2012034403 A1), N-[2-(5-Amino-1,3,4- thiadiazol-2-yl)-4-chlor-6-methylphenyl]-3-brom-1-(3-chlor-2 -pyridinyl)-1H-pyrazol-5-carboxamid (bekannt aus WO 2011085575 A1), 4-[3-[2,6-Dichlor-4-[(3,3-dichlor-2-propen-1-yl)oxy]phenoxy] propoxy]-2-methoxy-6-(trifluormethyl)-pyrimidin (bekannt aus CN 101337940 A); (2E)- und 2(Z)-2-[2- (4-Cyanophenyl)-1-[3-(trifluormethyl)phenyl]ethylidene]-N-[4 -(difluormethoxy)phenyl]-hydrazine- carboxamid (bekannt aus CN 101715774 A); 3-(2,2-Dichlorethenyl)-2,2-dimethyl-4-(1H-benzimidazol- 2-yl)phenyl-cyclopropan-carbonsäureester (bekannt aus CN 103524422 A); (4aS)-7-Chlor-2,5-dihydro- 2-[[(methoxycarbonyl)[4-[(trifluormethyl)thio]phenyl]amino]c arbonyl]-indeno[1,2-e][1,3,4]oxadiazine- 4a(3H)-carbosäuremethylester (bekannt aus CN 102391261 A). Safener sind vorzugsweise ausgewählt aus der Gruppe bestehend aus: S1) Verbindungen der Formel (S1), wobei die Symbole und Indizes folgende Bedeutungen haben: nA ist eine natürliche Zahl von 0 bis 5, vorzugsweise 0 bis 3; RA 1 ist Halogen, (C 1 -C 4 )-Alkyl, (C 1 -C 4 )-Alkoxy, Nitro oder (C 1 -C 4 )-Haloalkyl; - WA ist ein unsubstituierter oder substituierter divalenter heterocyclischer Rest aus der Gruppe der teilungesättigten oder aromatischen Fünfring-Heterocyclen mit 1 bis 3 Heteroringatomen aus der Gruppe N und O, wobei mindestens ein N-Atom und höchstens ein O-Atom im Ring enthalten ist, vorzugsweise ein Rest aus der Gruppe (WA 1 ) bis (WA 4 ), mA ist 0 oder 1; RA 2 ist ORA 3 , SRA 3 oder NRA 3 RA 4 oder ein gesättigter oder ungesättigter 3- bis 7-gliedriger Heterocyclus mit mindestens einem N-Atom und bis zu 3 Heteroatomen, vorzugsweise aus der Gruppe O und S, der über das N-Atom mit der Carbonylgruppe in (S1) verbunden ist und unsubstituiert oder durch Reste aus der Gruppe (C 1 -C 4 )-Alkyl, (C 1 -C 4 )-Alkoxy oder gegebenenfalls substituiertes Phenyl substituiert ist, vorzugsweise ein Rest der Formel ORA 3 , NHRA 4 oder N(CH 3 ) 2 , insbesondere der Formel OR A 3; R A 3 ist Wasserstoff oder ein unsubstituierter oder substituierter aliphatischer Kohlenwasserstoffrest, vorzugsweise mit insgesamt 1 bis 18 C-Atomen; R A 4 ist Wasserstoff, (C 1 -C 6 )-Alkyl, (C 1 -C 6 )-Alkoxy oder substituiertes oder unsubstituiertes Phenyl; R A 5 ist H, (C 1 -C 8 )-Alkyl, (C 1 -C 8 )-Haloalkyl, (C 1 -C 4 )-Alkoxy(C 1 -C 8 )-Alkyl, Cyano oder COOR A 9 , worin R A 9 Wasserstoff, (C 1 -C 8 )-Alkyl, (C 1 -C 8 )-Haloalkyl, (C 1 -C 4 )-Alkoxy-(C 1 -C 4 )-alkyl, (C 1 -C 6 )-Hydroxyalkyl, (C 3 -C 12 )-Cycloalkyl oder Tri-(C 1 -C 4 )-alkyl-silyl ist; R A 6 , R A 7 , R A 8 sind gleich oder verschieden Wasserstoff, (C 1 -C 8 )-Alkyl, (C 1 -C 8 )-Haloalkyl, (C 3 -C 12 )-Cycloalkyl oder substituiertes oder unsubstituiertes Phenyl; vorzugsweise: a) Verbindungen vom Typ der Dichlorphenylpyrazolin-3-carbonsäure (S1 a ), vorzugsweise Verbindungen wie 1-(2,4-Dichlorphenyl)-5-(ethoxycarbonyl)-5-methyl- 2-pyrazolin-3-carbonsäure, 1-(2,4-Dichlorphenyl)-5-(ethoxycarbonyl)-5-methyl-2-pyrazoli n-3-carbonsäureethylester (S1-1) ("Mefenpyr-diethyl"), und verwandte Verbindungen, wie sie in der WO-A-91/07874 beschrieben sind; b) Derivate der Dichlorphenylpyrazolcarbonsäure (S1 b ), vorzugsweise Verbindungen wie 1-(2,4-Dichlorphenyl)-5-methyl-pyrazol-3-carbonsäureethyles ter (S1-2), 1-(2,4-Di- chlorphenyl)-5-isopropyl-pyrazol-3-carbonsäureethylester (S1-3), 1-(2,4-Dichlor- phenyl)-5-(1,1-dimethyl-ethyl)pyrazol-3-carbonsäureethyl-es ter (S1-4) und verwandte Verbindungen, wie sie in EP-A-333131 und EP-A-269806 beschrieben sind; c) Derivate der 1,5-Diphenylpyrazol-3-carbonsäure (S1 c ), vorzugsweise Verbindungen wie 1-(2,4-Dichlorphenyl)-5-phenylpyrazol-3-carbonsäureethylest er (S1-5), 1-(2-Chlorphenyl)-5-phenylpyrazol-3-carbonsäuremethylester (S1-6) und verwandte Verbindungen wie sie beispielsweise in der EP-A-268554 beschrieben sind; d) Verbindungen vom Typ der Triazolcarbonsäuren (S1 d ), vorzugsweise Verbindungen wie Fenchlorazol(-ethylester), d.h.1-(2,4-Dichlorphenyl)-5-trichlormethyl-(1H)-1,2,4-triazo l-3-carbonsäure- ethylester (S1-7), und verwandte Verbindungen wie sie in EP-A-174562 und EP-A-346620 beschrieben sind; e) Verbindungen vom Typ der 5-Benzyl- oder 5-Phenyl-2-isoxazolin-3- carbonsäure oder der 5,5- Diphenyl-2-isoxazolin-3-carbonsäure (S1 e ), vorzugsweise Verbindungen wie 5-(2,4-Dichlorbenzyl)-2-isoxazolin-3-carbonsäureethylester (S1-8) oder 5-Phenyl-2-isoxazolin-3- carbonsäureethylester (S1-9) und verwandte Verbindungen, wie sie in WO-A-91/08202 beschrieben sind, bzw.5,5-Diphenyl-2-isoxazolin-3-carbonsäure (S1-10) oder 5,5-Diphenyl-2-isoxazolin-3- carbonsäureethylester (S1-11) ("Isoxadifen-ethyl") oder -n-propylester (S1-12) oder der 5-(4-Fluorphenyl)-5-phenyl-2-isoxazolin-3-carbonsäureethyle ster (S1-13), wie sie in der Patentanmeldung WO-A-95/07897 beschrieben sind. S2) Chinolinderivate der Formel (S2), wobei die Symbole und Indizes folgende Bedeutungen haben: RB 1 ist Halogen, (C 1 -C 4 )-Alkyl, (C 1 -C 4 )-Alkoxy, Nitro oder (C 1 -C 4 )-Haloalkyl; nB ist eine natürliche Zahl von 0 bis 5, vorzugsweise 0 bis 3; RB 2 ist ORB 3 , SRB 3 oder NRB 3 RB 4 oder ein gesättigter oder ungesättigter 3- bis 7-gliedriger Heterocyclus mit mindestens einem N-Atom und bis zu 3 Heteroatomen, vorzugsweise aus der Gruppe O und S, der über das N-Atom mit der Carbonylgruppe in (S2) verbunden ist und unsubstituiert oder durch Reste aus der Gruppe (C 1 -C 4 )-Alkyl, (C 1 -C 4 )-Alkoxy oder gegebenenfalls substituiertes Phenyl substituiert ist, vorzugsweise ein Rest der Formel OR B 3 , NHR B 4 oder N(CH 3 ) 2 , insbesondere der Formel OR B 3 ; R B 3 ist Wasserstoff oder ein unsubstituierter oder substituierter aliphatischer Kohlenwasserstoffrest, vorzugsweise mit insgesamt 1 bis 18 C-Atomen; RB 4 ist Wasserstoff, (C 1 -C 6 )-Alkyl, (C 1 -C 6 )-Alkoxy oder substituiertes oder unsubstituiertes Phenyl; TB ist eine (C 1 oder C 2 )-Alkandiylkette, die unsubstituiert oder mit einem oder zwei (C 1 -C 4 )- Alkylresten oder mit [(C 1 -C3)-Alkoxy]-carbonyl substituiert ist; vorzugsweise: a) Verbindungen vom Typ der 8-Chinolinoxyessigsäure (S2 a ), vorzugsweise (5-Chlor-8-chinolinoxy)essigsäure-(1-methylhexyl)ester ("Cloquintocet-mexyl") (S2-1), (5-Chlor-8- chinolinoxy)essigsäure-(1,3-dimethyl-but-1-yl)ester (S2-2), (5-Chlor-8-chinolinoxy)essigsäure-4-allyloxy-butylester (S2-3), (5-Chlor-8-chinolin-oxy)essigsäure-1- allyloxy-prop-2-ylester (S2-4), (5-Chlor-8-chinolinoxy)essigsäure-ethylester (S2-5), (5-Chlor-8- chinolinoxy)essigsäuremethylester (S2-6), (5-Chlor-8-chinolinoxy)essigsäureallylester (S2-7), (5-Chlor- 8-chinolinoxy)essigsäure-2-(2-propyliden-iminoxy)-1-ethyles ter (S2-8), (5-Chlor-8- chinolinoxy)essigsäure-2-oxo-prop-1-ylester (S2-9) und verwandte Verbindungen, wie sie in EP-A-86750, EP-A-94349 und EP-A-191736 oder EP-A-0492366 beschrieben sind, sowie (5-Chlor- 8-chinolinoxy)essigsäure (S2-10), deren Hydrate und Salze, beispielsweise deren Lithium-, Natrium- Kalium-, Kalzium-, Magnesium-, Aluminium-, Eisen-, Ammonium-, quartäre Ammonium-, Sulfonium-, oder Phosphoniumsalze wie sie in der WO-A-2002/34048 beschrieben sind; b) Verbindungen vom Typ der (5-Chlor-8-chinolinoxy)malonsäure (S2 b ), vorzugsweise Verbindungen wie (5-Chlor-8-chinolinoxy)malonsäurediethylester, (5-Chlor- 8-chinolinoxy)malonsäurediallylester, (5-Chlor-8-chinolinoxy)malonsäure-methyl-ethylester und verwandte Verbindungen, wie sie in EP-A-0582198 beschrieben sind. S3) Verbindungen der Formel (S3) wobei die Symbole und Indizes folgende Bedeutungen haben: R C 1 ist (C 1 -C 4 )-Alkyl, (C 1 -C 4 )-Haloalkyl, (C 2 -C 4 )-Alkenyl, (C 2 -C 4 )-Haloalkenyl, (C 3 -C 7 )-Cycloalkyl, vorzugsweise Dichlormethyl; R C 2 , R C 3 sind gleich oder verschieden Wasserstoff, (C 1 -C 4 )-Alkyl, (C 2 -C 4 )-Alkenyl, (C 2 -C 4 )-Alkinyl, (C 1 -C 4 )-Haloalkyl, (C 2 -C 4 )-Haloalkenyl, (C 1 -C 4 )-Alkylcarbamoyl-(C 1 -C 4 )-alkyl, (C 2 - C 4 )-Alkenylcarbamoyl-(C 1 -C 4 )-alkyl, (C 1 -C 4 )-Alkoxy-(C 1 -C 4 )-alkyl, Dioxolanyl-(C 1 -C 4 )-alkyl, Thiazolyl, Furyl, Furylalkyl, Thienyl, Piperidyl, substituiertes oder unsubstituiertes Phenyl, oder R C 2 und R C 3 bilden zusammen einen substituierten oder unsubstituierten heterocyclischen Ring, vorzugsweise einen Oxazolidin-, Thiazolidin-, Piperidin-, Morpholin-, Hexahydropyrimidin- oder Benzoxazinring; vorzugsweise: Wirkstoffe vom Typ der Dichloracetamide, die häufig als Vorauflaufsafener (bodenwirksame Safener) angewendet werden, wie z. B. "Dichlormid" (N,N-Diallyl-2,2-dichloracetamid) (S3-1), "R-29148" (3-Dichloracetyl-2,2,5- trimethyl-1,3-oxazolidin) der Firma Stauffer (S3-2), "R-28725" (3-Dichloracetyl-2,2,-dimethyl- 1,3-oxazolidin) der Firma Stauffer (S3-3), "Benoxacor" (4-Dichloracetyl-3,4-dihydro-3-methyl- 2H-1,4-benzoxazin) (S3-4), "PPG-1292" (N-Allyl-N-[(1,3-dioxolan-2-yl)-methyl]- dichloracetamid) der Firma PPG Industries (S3-5), "DKA-24" (N-Allyl-N- [(allylaminocarbonyl)methyl]-dichloracetamid) der Firma Sagro-Chem (S3-6), "AD-67" oder "MON 4660" (3-Dichloracetyl-1-oxa-3-aza-spiro[4,5]decan) der Firma Nitrokemia bzw. Monsanto (S3-7), "TI-35" (1-Dichloracetyl-azepan) der Firma TRI-Chemical RT (S3-8), "Diclonon" (Dicyclonon) oder "BAS145138" oder "LAB145138" (S3-9) ((RS)-1-Dichloracetyl- 3,3,8a-trimethylperhydropyrrolo[1,2-a]pyrimidin-6-on) der Firma BASF, "Furilazol" oder "MON 13900" ((RS)-3-Dichloracetyl-5-(2-furyl)-2,2-dimethyloxazolidin) (S3-10); sowie dessen (R)-Isomer (S3-11). S4) N-Acylsulfonamide der Formel (S4) und ihre Salze, worin die Symbole und Indizes folgende Bedeutungen haben: XD ist CH oder N; RD 1 ist CO-NRD 5 RD 6 oder NHCO-RD 7 ; RD 2 ist Halogen, (C 1 -C 4 )-Haloalkyl, (C 1 -C 4 )-Haloalkoxy, Nitro, (C 1 -C 4 )-Alkyl, (C 1 -C 4 )-Alkoxy, (C 1 -C 4 )-Alkylsulfonyl, (C 1 -C 4 )-Alkoxycarbonyl oder (C 1 -C 4 )-Alkylcarbonyl; R D 3 ist Wasserstoff, (C 1 -C 4 )-Alkyl, (C 2 -C 4 )-Alkenyl oder (C 2 -C 4 )-Alkinyl; R D 4 ist Halogen, Nitro, (C 1 -C 4 )-Alkyl, (C 1 -C 4 )-Haloalkyl, (C 1 -C 4 )-Haloalkoxy, (C 3 -C 6 )-Cycloalkyl, Phenyl, (C 1 -C 4 )-Alkoxy, Cyano, (C 1 -C 4 )-Alkylthio, (C 1 -C 4 )-Alkylsulfinyl, (C 1 -C 4 )- Alkylsulfonyl, (C 1 -C 4 )-Alkoxycarbonyl oder (C 1 -C 4 )-Alkylcarbonyl; R D 5 ist Wasserstoff, (C 1 -C 6 )-Alkyl, (C 3 -C 6 )-Cycloalkyl, (C 2 -C 6 )-Alkenyl, (C 2 -C 6 )-Alkinyl, (C 5 -C 6 )-Cycloalkenyl, Phenyl oder 3- bis 6-gliedriges Heterocyclyl enthaltend v D Heteroatome aus der Gruppe Stickstoff, Sauerstoff und Schwefel, wobei die sieben letztgenannten Reste durch vD Substituenten aus der Gruppe Halogen, (C 1 -C 6 )-Alkoxy, (C 1 -C 6 )-Haloalkoxy, (C 1 -C 2 )- Alkylsulfinyl, (C 1 -C 2 )-Alkylsulfonyl, (C 3 -C 6 )-Cycloalkyl, (C 1 -C 4 )-Alkoxycarbonyl, (C 1 -C 4 )- Alkylcarbonyl und Phenyl und im Falle cyclischer Reste auch (C 1 -C 4 )-Alkyl und (C 1 -C 4 )- Haloalkyl substituiert sind; RD 6 ist Wasserstoff, (C 1 -C 6 )-Alkyl, (C 2 -C 6 )-Alkenyl oder (C 2 -C 6 )-Alkinyl, wobei die drei letztgenannten Reste durch vD Reste aus der Gruppe Halogen, Hydroxy, (C 1 -C 4 )-Alkyl, (C 1 -C 4 )- Alkoxy und (C 1 -C 4 )-Alkylthio substituiert sind, oder RD 5 und RD 6 gemeinsam mit dem dem sie tragenden Stickstoffatom einen Pyrrolidinyl- oder Piperidinyl- Rest bilden; RD 7 ist Wasserstoff, (C 1 -C 4 )-Alkylamino, Di-(C 1 -C 4 )-alkylamino, (C 1 -C 6 )-Alkyl, (C 3 -C 6 )-Cycloalkyl, wobei die 2 letztgenannten Reste durch vD Substituenten aus der Gruppe Halogen, (C 1 -C 4 )- Alkoxy, (C 1 -C 6 )-Haloalkoxy und (C 1 -C 4 )-Alkylthio und im Falle cyclischer Reste auch (C 1 -C 4 )- Alkyl und (C 1 -C 4 )-Haloalkyl substituiert sind; nD ist 0, 1 oder 2; mD ist 1 oder 2; vD ist 0, 1, 2 oder 3; davon bevorzugt sind Verbindungen vom Typ der N-Acylsulfonamide, z.B. der nachfolgenden Formel (S4 a ), die z. B. bekannt sind aus WO-A-97/45016 worin RD 7 (C 1 -C 6 )-Alkyl, (C 3 -C 6 )-Cycloalkyl, wobei die 2 letztgenannten Reste durch vD Substituenten aus der Gruppe Halogen, (C 1 -C 4 )-Alkoxy, (C 1 -C 6 )-Haloalkoxy und (C 1 -C 4 )-Alkylthio und im Falle cyclischer Reste auch (C 1 -C 4 )-Alkyl und (C 1 -C 4 )-Haloalkyl substituiert sind; RD 4 Halogen, (C 1 -C 4 )-Alkyl, (C 1 -C 4 )-Alkoxy, CF 3 ; mD 1 oder 2; v D ist 0, 1, 2 oder 3 bedeutet; sowie Acylsulfamoylbenzoesäureamide, z.B. der nachfolgenden Formel (S4 b ), die z.B. bekannt sind aus WO-A-99/16744, z.B. solche worin R D 5 = Cyclopropyl und (R D 4 ) = 2-OMe ist ("Cyprosulfamide", S4-1), R D 5 = Cyclopropyl und (R D 4 ) = 5-Cl-2-OMe ist (S4-2), R D 5 = Ethyl und (R D 4 ) = 2-OMe ist (S4-3), R D 5 = Isopropyl und (R D 4 ) = 5-Cl-2-OMe ist (S4-4) und R D 5 = Isopropyl und (R D 4 ) = 2-OMe ist (S4-5). sowie Verbindungen vom Typ der N-Acylsulfamoylphenylharnstoffe der Formel (S4 c ), die z.B. bekannt sind aus der EP-A-365484, worin R D 8 und R D 9 unabhängig voneinander Wasserstoff, (C 1 -C 8 )-Alkyl, (C 3 -C 8 )-Cycloalkyl, (C 3 -C 6 )-Alkenyl, (C 3 -C 6 )-Alkinyl, R D 4 Halogen, (C 1 -C 4 )-Alkyl, (C 1 -C 4 )-Alkoxy, CF 3 mD 1 oder 2 bedeutet; beispielsweise 1-[4-(N-2-Methoxybenzoylsulfamoyl)phenyl]-3-methylharnstoff, 1-[4-(N-2-Methoxybenzoylsulfamoyl)phenyl]-3,3-dimethylharnst off, 1-[4-(N-4,5-Dimethylbenzoylsulfamoyl)phenyl]-3-methylharnsto ff. S5) Wirkstoffe aus der Klasse der Hydroxyaromaten und der aromatisch-aliphatischen Carbonsäurederivate (S5), z.B.3,4,5-Triacetoxybenzoesäureethylester, 3,5-Di-methoxy-4- hydroxybenzoesäure, 3,5-Dihydroxybenzoesäure, 4-Hydroxysalicylsäure, 4-Fluorsalicyclsäure, 2- Hydroxyzimtsäure, 2,4-Dichlorzimtsäure, wie sie in der WO-A-2004/084631, WO-A-2005/015994, WO-A-2005/016001 beschrieben sind. S6) Wirkstoffe aus der Klasse der 1,2-Dihydrochinoxalin-2-one (S6), z.B. 1-Methyl-3-(2-thienyl)-1,2-dihydrochinoxalin-2-on, 1-Methyl-3-(2-thienyl)-1,2-dihydrochinoxalin-2- thion, 1-(2-Aminoethyl)-3-(2-thienyl)-1,2-dihydro-chinoxalin-2-on-h ydrochlorid, 1-(2- Methylsulfonylaminoethyl)-3-(2-thienyl)-1,2-dihydrochinoxa-l in-2-on, wie sie in der WO-A- 2005/112630 beschrieben sind. S7) Verbindungen der Formel (S7), wie sie in der WO-A-1998/38856 beschrieben sind worin die Symbole und Indizes folgende Bedeutungen haben: R E 1 , R E 2 sind unabhängig voneinander Halogen, (C 1 -C 4 )-Alkyl, (C 1 -C 4 )-Alkoxy, (C 1 -C 4 )-Haloalkyl, (C 1 -C 4 )-Alkylamino, Di-(C 1 -C 4 )-Alkylamino, Nitro; AE ist COORE 3 oder COSRE 4 RE 3 , RE 4 sind unabhängig voneinander Wasserstoff, (C 1 -C 4 )-Alkyl, (C 2 -C 6 )-Alkenyl, (C 2 -C 4 )-Alkinyl, Cyanoalkyl, (C 1 -C 4 )-Haloalkyl, Phenyl, Nitrophenyl, Benzyl, Halobenzyl, Pyridinylalkyl und Alkylammonium, nE 1 ist 0 oder 1 nE 2 , nE 3 sind unabhängig voneinander 0, 1 oder 2, vorzugsweise Diphenylmethoxyessigsäure, Diphenylmethoxyessigsäureethylester, Diphenyl- methoxyessigsäuremethylester (CAS-Reg.Nr.41858-19-9) (S7-1). S8) Verbindungen der Formel (S8),wie sie in der WO-A-98/27049 beschrieben sind Worin X F CH oder N, n F für den Fall, dass X F =N ist, eine ganze Zahl von 0 bis 4 und für den Fall, dass X F =CH ist, eine ganze Zahl von 0 bis 5 , R F 1 Halogen, (C 1 -C 4 )-Alkyl, (C 1 -C 4 )-Haloalkyl, (C 1 -C 4 )-Alkoxy, (C 1 -C 4 )-Haloalkoxy, Nitro, (C 1 -C 4 )-Alkylthio, (C 1 -C 4 )-Alkylsulfonyl, (C 1 -C 4 )-Alkoxycarbonyl, ggf. substituiertes. Phenyl, ggf. substituiertes Phenoxy, RF 2 Wasserstoff oder (C 1 -C 4 )-Alkyl RF 3 Wasserstoff, (C 1 -C 8 )-Alkyl, (C 2 -C 4 )-Alkenyl, (C 2 -C 4 )-Alkinyl, oder Aryl, wobei jeder der vorgenannten C-haltigen Reste unsubstituiert oder durch einen oder mehrere, vorzugsweise bis zu drei gleiche oder verschiedene Reste aus der Gruppe, bestehend aus Halogen und Alkoxy substituiert ist; bedeuten, oder deren Salze, vorzugsweise Verbindungen worin XF CH, nF eine ganze Zahl von 0 bis 2, RF 1 Halogen, (C 1 -C 4 )-Alkyl, (C 1 -C 4 )-Haloalkyl, (C 1 -C 4 )-Alkoxy, (C 1 -C 4 )-Haloalkoxy, RF 2 Wasserstoff oder (C 1 -C 4 )-Alkyl, RF 3 Wasserstoff, (C 1 -C 8 )-Alkyl, (C 2 -C 4 )-Alkenyl, (C 2 -C 4 )-Alkinyl, oder Aryl, wobei jeder der vorgenannten C-haltigen Reste unsubstituiert oder durch einen oder mehrere, vorzugsweise bis zu drei gleiche oder verschiedene Reste aus der Gruppe, bestehend aus Halogen und Alkoxy substituiert ist, bedeuten, oder deren Salze. S9) Wirkstoffe aus der Klasse der 3-(5-Tetrazolylcarbonyl)-2-chinolone (S9), z.B. 1,2-Dihydro-4-hydroxy-1-ethyl-3-(5-tetrazolylcarbonyl)-2-chi nolon (CAS-Reg.Nr.219479-18-2), 1,2-Dihydro-4-hydroxy-1-methyl-3-(5-tetrazolyl-carbonyl)-2-c hinolon (CAS-Reg.Nr.95855-00-8), wie sie in der WO-A-1999/000020 beschrieben sind. S10) Verbindungen der Formeln (S10 a ) oder (S10 b ) wie sie in der WO-A-2007/023719 und WO-A-2007/023764 beschrieben sind worin R G 1 Halogen, (C 1 -C 4 )-Alkyl, Methoxy, Nitro, Cyano, CF 3 , OCF 3 Y G , Z G unabhängig voneinander O oder S, n G eine ganze Zahl von 0 bis 4, R G 2 (C 1 -C 16 )-Alkyl, (C 2 -C 6 )-Alkenyl, (C 3 -C 6 )-Cycloalkyl, Aryl; Benzyl, Halogenbenzyl, R G 3 Wasserstoff oder (C 1 -C 6 )-Alkyl bedeutet. S11) Wirkstoffe vom Typ der Oxyimino-Verbindungen (S11), die als Saatbeizmittel bekannt sind, wie z. B. "Oxabetrinil" ((Z)-1,3-Dioxolan-2-ylmethoxyimino(phenyl)acetonitril) (S11-1), das als Saatbeiz-Safener für Hirse gegen Schäden von Metolachlor bekannt ist, "Fluxofenim" (1-(4- Chlorphenyl)-2,2,2-trifluor-1-ethanon-O-(1,3-dioxolan-2-ylme thyl)-oxim) (S11-2), das als Saatbeiz- Safener für Hirse gegen Schäden von Metolachlor bekannt ist, und "Cyometrinil" oder "CGA-43089" ((Z)-Cyanomethoxyimino(phenyl)acetonitril) (S11-3), das als Saatbeiz-Safener für Hirse gegen Schäden von Metolachlor bekannt ist. S12) Wirkstoffe aus der Klasse der Isothiochromanone (S12), wie z.B. Methyl-[(3-oxo-1H-2- benzothiopyran-4(3H)-yliden)methoxy]acetat (CAS-Reg.Nr.205121-04-6) (S12-1) und verwandte Verbindungen aus WO-A-1998/13361. S13) Eine oder mehrere Verbindungen aus Gruppe (S13): "Naphthalic anhydrid" (1,8-Naphthalindicarbonsäureanhydrid) (S13-1), das als Saatbeiz-Safener für Mais gegen Schäden von Thiocarbamatherbiziden bekannt ist, "Fenclorim" (4,6-Dichlor-2-phenylpyrimidin) (S13-2), das als Safener für Pretilachlor in gesätem Reis bekannt ist, "Flurazole" (Benzyl-2-chlor-4-trifluormethyl-1,3- thiazol-5-carboxylat) (S13-3), das als Saatbeiz-Safener für Hirse gegen Schäden von Alachlor und Metolachlor bekannt ist, "CL 304415" (CAS-Reg.Nr.31541-57-8) (4-Carboxy-3,4-dihydro-2H-1- benzopyran-4-essigsäure) (S13-4) der Firma American Cyanamid, das als Safener für Mais gegen Schäden von Imidazolinonen bekannt ist, "MG 191" (CAS-Reg.Nr.96420-72-3) (2-Dichlormethyl-2- methyl-1,3-dioxolan) (S13-5) der Firma Nitrokemia, das als Safener für Mais bekannt ist, "MG-838" (CAS-Reg.Nr.133993-74-5) (2-propenyl 1-oxa-4-azaspiro[4.5]decan-4-carbodithioat) (S13-6) der Firma Nitrokemia, "Disulfoton" (O,O-Diethyl S-2-ethylthioethyl phosphordithioat) (S13-7), "Dietholate" (O,O-Diethyl-O-phenylphosphorothioat) (S13-8), "Mephenate" (4-Chlorphenyl- methylcarbamat) (S13-9). S14) Wirkstoffe, die neben einer herbiziden Wirkung gegen Schadpflanzen auch Safenerwirkung an Kulturpflanzen wie Reis aufweisen, wie z. B. "Dimepiperate" oder "MY-93" (S-1-Methyl-1-phenylethyl-piperidin-1-carbothioat), das als Safener für Reis gegen Schäden des Herbizids Molinate bekannt ist, "Daimuron" oder "SK 23" (1-(1-Methyl-1- phenylethyl)-3-p-tolyl-harnstoff), das als Safener für Reis gegen Schäden des Herbizids Imazosulfuron bekannt ist, "Cumyluron" = "JC-940" (3-(2-Chlorphenylmethyl)-1-(1-methyl-1-phenyl-ethyl)harnstof f, siehe JP-A-60087254), das als Safener für Reis gegen Schäden einiger Herbizide bekannt ist, "Methoxyphenon" oder "NK 049" (3,3'-Dimethyl-4-methoxy-benzophenon), das als Safener für Reis gegen Schäden einiger Herbizide bekannt ist, "CSB" (1-Brom-4-(chlormethylsulfonyl)benzol) von Kumiai, (CAS-Reg.Nr.54091-06-4), das als Safener gegen Schäden einiger Herbizide in Reis bekannt ist. S15) Verbindungen der Formel (S15) oder deren Tautomere wie sie in der WO-A-2008/131861 und WO-A-2008/131860 beschrieben sind worin R H 1 einen (C 1 -C 6 )-Haloalkylrest bedeutet und R H 2 Wasserstoff oder Halogen bedeutet und R H 3 , R H 4 unabhängig voneinander Wasserstoff, (C 1 -C 16 )-Alkyl, (C 2 -C 16 )-Alkenyl oder (C 2 -C 16 )-Alkinyl, wobei jeder der letztgenannten 3 Reste unsubstituiert oder durch einen oder mehrere Reste aus der Gruppe Halogen, Hydroxy, Cyano, (C 1 -C 4 )-Alkoxy, (C 1 -C 4 )-Haloalkoxy, (C 1 -C 4 )-Alkylthio, (C 1 -C 4 )-Alkylamino, Di[(C 1 -C 4 )-alkyl]-amino, [(C 1 -C 4 )-Alkoxy]-carbonyl, [(C 1 -C 4 )- Haloalkoxy]-carbonyl, (C 3 -C 6 )-Cycloalkyl, das unsubstituiert oder substituiert ist, Phenyl, das unsubstituiert oder substituiert ist, und Heterocyclyl, das unsubstituiert oder substituiert ist, substituiert ist, oder (C 3 -C 6 )-Cycloalkyl, (C 4 -C 6 )-Cycloalkenyl, (C 3 -C 6 )-Cycloalkyl, das an einer Seite des Rings mit einem 4 bis 6-gliedrigen gesättigten oder ungesättigten carbocyclischen Ring kondensiert ist, oder (C 4 -C 6 )-Cycloalkenyl, das an einer Seite des Rings mit einem 4 bis 6- gliedrigen gesättigten oder ungesättigten carbocyclischen Ring kondensiert ist, wobei jeder der letztgenannten 4 Reste unsubstituiert oder durch einen oder mehrere Reste aus der Gruppe Halogen, Hydroxy, Cyano, (C 1 -C 4 )-Alkyl, (C 1 -C 4 )-Haloalkyl, (C 1 -C 4 )-Alkoxy, (C 1 -C 4 )- Haloalkoxy, (C 1 -C 4 )-Alkylthio, (C 1 -C 4 )-Alkylamino, Di[(C 1 -C 4 )-alkyl]-amino, [(C 1 -C 4 )Alkoxy]- carbonyl, [(C 1 -C 4 )-Haloalkoxy]-carbonyl, (C 3 -C 6 )-Cycloalkyl, das unsubstituiert oder substituiert ist, Phenyl, das unsubstituiert oder substituiert ist, und Heterocyclyl, das unsubstituiert oder substituiert ist, substituiert ist, bedeutet oder RH 3 (C 1 -C 4 )-Alkoxy, (C 2 -C 4 )-Alkenyloxy, (C 2 -C 6 )-Alkinyloxy oder (C 2 -C 4 )-Haloalkoxy bedeutet und RH 4 Wasserstoff oder (C 1 -C 4 )-Alkyl bedeutet oder RH 3 und RH 4 zusammen mit dem direkt gebundenen N-Atom einen vier- bis achtgliedrigen heterocyclischen Ring, der neben dem N-Atom auch weitere Heteroringatome, vorzugsweise bis zu zwei weitere Heteroringatome aus der Gruppe N, O und S enthalten kann und der unsubstituiert oder durch einen oder mehrere Reste aus der Gruppe Halogen, Cyano, Nitro, (C 1 -C 4 )-Alkyl, (C 1 -C 4 )-Haloalkyl, (C 1 -C 4 )-Alkoxy, (C 1 -C 4 )-Haloalkoxy und (C 1 -C 4 )-Alkylthio substituiert ist, bedeutet. S16) Wirkstoffe, die vorrangig als Herbizide eingesetzt werden, jedoch auch Safenerwirkung auf Kulturpflanzen aufweisen, z.B. (2,4-Dichlorphenoxy)essigsäure (2,4-D), (4-Chlorphenoxy)essigsäure, (R,S)-2-(4-Chlor-o-tolyloxy)propionsäure (Mecoprop), 4-(2,4-Dichlorphenoxy)buttersäure (2,4-DB), (4- Chlor-o-tolyloxy)-essigsäure (MCPA), 4-(4-Chlor-o-tolyloxy)buttersäure, 4-(4-Chlorphenoxy)- buttersäure, 3,6-Dichlor-2-methoxybenzoesäure (Dicamba), 1-(Ethoxycarbonyl)ethyl-3,6-dichlor-2- methoxybenzoat (Lactidichlor-ethyl). Pflanzenreife beeinflussende Stoffe: Als Kombinationspartner für die Verbindungen der allgemeinen Formel (I) in Mischungsformulierungen oder im Tank-Mix sind beispielsweise bekannte Wirkstoffe, die auf einer Inhibition von beispielsweise 1-Aminocyclopropan-1-carboxylatsynthase, 1-aminocyclopropane-1-carboxylatoxidase und den Ethylenrezeptoren, z. B. ETR1, ETR2, ERS1, ERS2 oder EIN4, beruhen, einsetzbar, wie sie z. B. in Biotechn. Adv.2006, 24, 357-367; Bot. Bull. Acad. Sin.199, 40, 1-7 oder Plant Growth Reg.1993, 13, 41-46 und dort zitierter Literatur beschrieben sind. Als bekannte die Pflanzenreife beeinflussende Stoffe, die mit den Verbindungen der allgemeinen Formel (I) kombiniert werden können, sind z.B. folgende Wirkstoffe zu nennen (die Verbindungen sind entweder mit dem "common name" nach der International Organization for Standardization (ISO) oder mit dem chemischen Namen oder mit der Codenummer bezeichnet) und umfassen stets sämtliche Anwendungsformen wie Säuren, Salze, Ester und Isomere wie Stereoisomere und optische Isomere. Dabei sind beispielhaft eine und zum Teil auch mehrere Anwendungsformen genannt: Rhizobitoxin, 2-Amino-ethoxy-vinylglycin (AVG), Methoxyvinylglycin (MVG), Vinylglycin, Aminooxyessigsäure, Sinefungin, S-Adenosylhomocystein, 2-Keto-4-Methylthiobutyrat, (Isopropyliden)-aminooxyessigsäure-2-(methoxy)-2-oxoethyles ter, (Isopropyliden)- aminooxyessigsäure-2-(hexyloxy)-2-oxoethylester, (Cyclohexyliden)-aminooxyessigsäure-2- (isopropyloxy)-2-oxoethylester, Putrescin, Spermidin, Spermin, 1,8-Diamino-4-aminoethyloctan, L- Canalin, Daminozid, 1-Aminocyclopropyl-1-carbonsäure-methylester, N-Methyl-1-aminocyclopropyl-1- carbonsäure, 1-Aminocyclopropyl-1-carbonsäureamid, Substituierte 1-Aminocyclopropyl-1- carbonsäurederivate wie sie in DE3335514, EP30287, DE2906507 oder US5123951 beschrieben werden, 1-Aminocyclopropyl-1-hydroxamsäure, 1-Methylcyclopropen, 3-Methylcyclopropen, 1- Ethylcyclopropen, 1-n-Propylcyclopropen, 1-Cyclopropenyl-Methanol, Carvon, Eugenol, Natriumcycloprop-1-en-1-ylacetat, Natriumcycloprop-2-en-1-ylacetat, Natrium-3-(cycloprop-2-en-1- yl)propanoat, Natrium-3-(cycloprop-1-en-1-yl)propanoat, Jasmonsäure, Jasmonsäuremethylester, Jasmonsäureethylester, Prohydrojasmon, 2-Fluor-N-(3-methoxyphenyl)-9H-purin-6-amin. Pflanzengesundheit und Keimung beeinflussende Stoffe: Als Kombinationspartner für die Verbindungen der allgemeinen Formel (I) in Mischungsformulierungen oder im Tank-Mix sind beispielsweise bekannte Wirkstoffe, die die Pflanzengesundheit oder die Keimung beeinflussen, einsetzbar (die Verbindungen sind entweder mit dem "common name" nach der International Organization for Standardization (ISO) oder mit dem chemischen Namen oder mit der Codenummer bezeichnet und umfassen stets sämtliche Anwendungsformen wie Säuren, Salze, Ester und Isomere wie Stereoisomere und optische Isomere): Sarcosin, Phenylalanin, Tryptophan, N'-Methyl-1- phenyl-1-N,N-diethylaminomethanesulfonamid, Apio-galacturonane wie sie in WO2010017956 beschrieben werden, 4-Oxo-4-[(2-phenylethyl)amino]butansäure, 4-{[2-(1H-Indol-3-yl)ethyl]amino}-4- oxobutansäure, 4-[(3-Methylpyridin-2-yl)amino]-4-oxobutansäure, Allantoin, 5-Aminolevulinsäure, (2S,3R)-2-(3,4-Dihydroxyphenyl)-3,4-dihydro-2H-chromen-3,5,7 -triol und strukturell verwandte Catechine wie sie in WO2010122956 beschrieben werden, 2-Hydroxy-4-(methylsulfanyl)butansäure, (3Ε,3αR,8βS)-3-({[(2R)-4-Methyl-5-oxo-2,5-dihydrofuran-2- yl]oxy}methylen)-3,3α,4,8β-tetrahydro- 2H-indeno[1,2-b]furan-2-on und analoge Lactone wie sie in EP2248421 beschrieben werden, Abscisinsäure, (2Z,4E)-5-[6-Ethinyl-1-hydroxy-2,6-dimethyl-4-oxocyclohex-2- en-1-yl]-3-methylpenta- 2,4-diensäure, Methyl-(2Z,4E)-5-[6-ethinyl-1-hydroxy-2,6-dimethyl-4-oxocycl ohex-2-en-1-yl]-3- methylpenta-2,4-dienoat, 4-Phenylbuttersäure, Natrium-4-phenylbutanoat, Kalium-4-phenylbutanoat. Herbizide oder Pflanzenwachstumsregulatoren: Als Kombinationspartner für die Verbindungen der allgemeinen Formel (I) in Mischungsformulierungen oder im Tank-Mix sind beispielsweise bekannte Wirkstoffe, die auf einer Inhibition von beispielsweise Acetolactat-Synthase, Acetyl-CoA-Carboxylase, Cellulose-Synthase, Enolpyruvylshikimat-3-phosphat- Synthase, Glutamin-Synthetase, p-Hydroxyphenylpyruvat-Dioxygenase, Phytoendesaturase, Photosystem I, Photosystem II, Protoporphyrinogen-Oxidase beruhen oder als Pflanzenwuchsregulatoren wirken, einsetzbar, wie sie z.B. aus Weed Research 26 (1986) 441-445 oder "The Pesticide Manual", 14th edition, The British Crop Protection Council and the Royal Soc. of Chemistry, 2006 und dort zitierter Literatur beschrieben sind. Als bekannte Herbizide oder Pflanzenwachstumsregulatoren, die mit Verbindungen der allgemeinen Formel (I) kombiniert werden können, sind z.B. folgende Wirkstoffe zu nennen (die Verbindungen sind entweder mit dem "common name" nach der International Organization for Standardization (ISO) oder mit dem chemischen Namen oder mit der Codenummer bezeichnet) und umfassen stets sämtliche Anwendungsformen wie Säuren, Salze, Ester und Isomere wie Stereoisomere und optische Isomere. Dabei sind beispielhaft eine und zum Teil auch mehrere Anwendungsformen genannt: Acetochlor, Acifluorfen, Acifluorfen-methyl, Acifluorfen-Natrium, Aclonifen, Alachlor, Allidochlor, Alloxydim, Alloxydim-Natrium, Ametryn, Amicarbazon, Amidochlor, Amidosulfuron, 4-Amino-3- chlor-6-(4-chlor-2-fluor-3-methylphenyl)-5-fluorpyridine-2-c arbonsäure, Aminocyclopyrachlor, Aminocyclopyrachlor-potassium, Aminocyclopyrachlor-methyl, Aminopyralid, Aminopyralid- dimethylammonium, Aminopyralid-tripromine, Amitrole, Ammoniumsulfamate, Anilofos, Asulam, Asulam-Kalium, Asulam-Natrium, Atrazin, Azafenidin, Azimsulfuron, Beflubutamid, (S)-(-)- Beflubutamid, Beflubutamid-M, Benazolin, Benazolin-ethyl, Benazolin-dimethylammonium, Benazolin-Klaium, Benfluralin, Benfuresate, Bensulfuron, Bensulfuron-methyl, Bensulid, Bentazon, Bentazon-Natrium, Benzobicyclon, Benzofenap, Bicyclopyrone, Bifenox, Bilanafos, Bilanafos-Natium, Bipyrazone, Bispyribac, Bispyribac-Natium, Bixlozon, Bromacil, Bromacil-lithium, Bromacil-Natrium, Bromobutid, Bromofenoxim, Bromoxynil, Bromoxynilbutyrat, Bromoxynil-Kalium, Bromoxynil- heptanoat und Bromoxynil-octanoat, Busoxinon, Butachlor, Butafenacil, Butamifos, Butenachlor, Butralin, Butroxydim, Butylat, Cafenstrol, Cambendichlor, Carbetamide, Carfentrazon, Carfentrazon- Ethyl, Chloramben, Chloramben-ammonium, Chloramben-diolamin, Chlroamben-methyl, Chloramben- methylammonium, Chloramben-Natium, Chlorbromuron, Chlorfenac, Chlorfenac-ammonium, Chlorfenac-Natium, Chlorfenprop, Chlorfenprop-methyl, Chlorflurenol, Chlorflurenol-methyl, Chloridazon, Chlorimuron, Chlorimuron-ethyl, Chlorphthalim, Chlortoluron, Chlorosulfuron, Chlorthal, Chlorthal-dimethyl, Chlorthal-monomethyl, Cinidon, Cinidon-ethyl, Cinmethylin, exo-(+)-Cinmethylin, i.e. (1R,2S,4S)-4-isopropyl-1-methyl-2-[(2-methylbenzyl)oxy]-7-ox abicyclo[2.2.1]heptan, exo-(-)- Cinmethylin, i.e. (1R,2S,4S)-4-isopropyl-1-methyl-2-[(2-methylbenzyl)oxy]-7-ox abicyclo[2.2.1]heptan, Cinosulfuron, Clacyfos, Clethodim, Clodinafop, Clodinafop-ethyl, Clodinafop-propargyl, Clomazon, Clomeprop, Clopyralid, Clopyralid-methyl, Clopyralid-olamin, Clopyralid-Kalium, Clopyralid- tripomin, Cloransulam, Cloransulam-methyl, Cumyluron, Cyanamide, Cyanazine, Cycloat, Cyclopyranil, Cyclopyrimorat, Cyclosulfamuron, Cycloxydim, Cyhalofop, Cyhalofop-butyl, Cyprazin, 2,4-D (sowie die Ammonium, Butotyl, Butyl, Cholin, Diethylammonium, Dimethylammonium, Diolamin, Doboxyl, Dodecylammonium, Etexyl, Ethyl, 2-Ethylhexyl, Heptylammonium, Isobutyl, Isooctyl, Isopropyl, Isopropylammonium, Lithium, Meptyl, Methyl, Kalium, Tetradecylammonium, Triethylammonium, Triisopropanolammonium, Tripromin and Trolamin Salze davon), 2,4-DB, 2,4-DB- butyl, 2,4-DB-Dimethylammonium, 2,4-DB-isooctyl, 2,4-DB-Kalium und 2,4-DB-Natrium, Daimuron (Dymron), Dalapon, Dalapon-Calcium, Dalapon-Magnesium, Dalapon-Natium, Dazomet, Dazomet- Natrium, n-Decanol, 7-Deoxy-D-sedoheptulose, Desmedipham, Detosyl-pyrazolat (DTP), Dicamba und seine Salze (z.B. Dicamba-biproamine, Dicamba-N,N-Bis(3-aminopropyl)methylamine, Dicamba- butotyl, Dicamba-choline, Dicamba-Diglycolamine, Dicamba-Dimethylammonium, Dicamba- Diethanolaminemmonium, Dicamba-Diethylammonium, Dicamba-isopropylammonium, Dicamba- methyl, Dicamba-monoethanolamin, Dicamba-olamin, Dicamba-Kalium, Dicamba-Natium, Dicamba- Triethanolamin), Dichlobenil, 2-(2,4-Dichlorbenzyl)-4,4-dimethyl-1,2-oxazolidin-3-on, 2-(2,5- Dichlorbenzyl)-4,4-dimethyl-1,2-oxazolidin-3-one, Dichlorprop, Dichlorprop-butotyl, Dichlorprop- Dimethylammonium, Dichhlorprop-etexyl, Dichlorprop-ethylammonium, Dichlorprop-isoctyl, Dichlorprop-methyl, Dichlorprop-Kalium, Dichlorprop-Natrium, Dichlorprop-P, Dichlorprop-P- Dimethylammonium, Dichlorprop-P-etexyl, Dichlorprop-P-potassium, Dichlorprop-Natrium, Diclofop, Diclofop-methyl, Diclofop-P, Diclofop-P-methyl, Diclosulam, Difenzoquat, Difenzoquat-metilsulfate, Diflufenican, Diflufenzopyr, Diflufenzopyr-Natrium, Dimefuron, Dimepiperate, Dimesulfazet, Dimethachlor, Dimethametryn, Dimethenamid, Dimethenamid-P, Dimetrasulfuron, Dinitramine, Dinoterb, Dinoterb-Acetate, Diphenamid, Diquat, Diquat-Dibromid, Diquat-Dichloride, Dithiopyr, Diuron, DNOC, DNOC-Ammonium, DNOC-Kalium, DNOC-Natrium, Endothal, Endothal- Diammonium, Endothal-Dikalium, Endothal-Dinatrium, Epyrifenacil (S-3100), EPTC, Esprocarb, Ethalfluralin, Ethametsulfuron, Ethametsulfuron-Methyl, Ethiozin, Ethofumesate, Ethoxyfen, Ethoxyfen-Ethyl, Ethoxysulfuron, Etobenzanid, F-5231, i.e. N-[2-Chlor-4-fluor-5-[4-(3-fluorpropyl)- 4,5-dihydro-5-oxo-1H-tetrazol-1-yl]-phenyl]-ethansulfonamid, F-7967, i.e.3-[7-Chlor-5-fluor-2- (trifluormethyl)-1H-benzimidazol-4-yl]-1-methyl-6-(trifluorm ethyl)pyrimidin-2,4(1H,3H)-dion, Fenoxaprop, Fenoxaprop-P, Fenoxaprop-Ethyl, Fenoxaprop-P-Ethyl, Fenoxasulfone, Fenpyrazone, Fenquinotrione, Fentrazamid, Flamprop, Flamprop-Isoproyl, Flamprop-Methyl, Flamprop-M-Isopropyl, Flamprop-M-Methyl, Flazasulfuron, Florasulam, Florpyrauxifen, Florpyrauxifen-benzyl, Fluazifop, Fluazifop-Butyl, Fluazifop-Methyl, Fluazifop-P, Fluazifop-P-Butyl, Flucarbazone, Flucarbazone- sodium, Flucetosulfuron, Fluchloralin, Flufenacet, Flufenpyr, Flufenpyr-Ethyl, Flumetsulam, Flumiclorac, Flumiclorac-Pentyl, Flumioxazin, Fluometuron, Flurenol, Flurenol-Butyl, - Dimethylammonium und -Methyl, Fluorglycofen, Fluorglycofen-Ethyl, Flupropanat, Flupropanat- Natrium, Flupyrsulfuron, Flupyrsulfuron-Methyl, Flupyrsulfuron-Methyl-Natrium, Fluridon, Flurochloridon, Fluroxypyr, Fluroxypyr-Butometyl, Fluroxypyr-Meptyl, Flurtamon, Fluthiacet, Fluthiacet-Methyl, Fomesafen, Fomesafen-Natrium, Foramsulfuron, Foramsulfuron-Natrium, Fosamine, Fosamine-Ammonium, Glufosinat, Glufosinat-Ammonium, Glufosinat-Natrium, L-Glufosinat- Ammonium, L-Glufosinat-Natrium, Glufosinat-P-Natrium, Glufosinat-P-Ammonium, Glyphosat, Glyphosat-Ammonium, Glyphosat-Isopropylammonium, Glyphosat-Diammonium, Glyphosat- Dimethylammonium, Glyphosat-Kalium, Glyphosat-Natrium, Glyphosat-Sesquinatrium und Glyphosat- Trimesium, H-9201, i.e. O-(2,4-Dimethyl-6-nitrophenyl)-O-ethyl-isopropylphosphoramid othioat, Halauxifen, Halauxifen-methyl, Halosafen, Halosulfuron, Halosulfuron-Methyl, Haloxyfop, Haloxyfop- P, Haloxyfop-Ethoxyethyl, Haloxyfop-P-Ethoxyethyl, Haloxyfop-Methyl, Haloxyfop-P-Methyl, Haloxifop-Natrium, Hexazinon, HNPC-A8169, i.e. Prop-2-yn-1-yl (2S)-2-{3-[(5-tert-butylpyridin-2- yl)oxy]phenoxy}propanoat, HW-02, i.e.1-(Dimethoxyphosphoryl)-ethyl-(2,4-dichlorphenoxy)acetat , Hydantocidin, Imazamethabenz, Imazamethabenz-Methyl, Imazamox, Imazamox-Ammonium, Imazapic, Imazapic-Ammonium, Imazapyr, Imazapyr-Isopropylammonium, Imazaquin, Imazaquin- Ammonium, Imazaquin-Methyl, Imazethapyr, Imazethapyr-Ammonium, Imazosulfuron, Indanofan, Indaziflam, Iodosulfuron, Iodosulfuron-Methyl, Iodosulfuron-Methyl-Natrium, Ioxynil, Ioxynil- Lithium, -Octanoat, -Kalium und Natrium, Ipfencarbazon, Isoproturon, Isouron, Isoxaben, Isoxaflutole, Karbutilat, KUH-043, i.e.3-({[5-(Difluormethyl)-1-methyl-3-(trifluormethyl)-1H-py razol-4- yl]methyl}sulfonyl)-5,5-dimethyl-4,5-dihydro-1,2-oxazol, Ketospiradox, Ketospiradox-Kalium, Lactofen, Lenacil, Linuron, MCPA, MCPA-Butotyl, -Butyl, -Dimethylammonium, -Diolamin, -2- Ethylhexyl, -Ethyl, -Isobutyl, Isoctyl, -Isopropyl, -Isopropylammonium, -Methyl, Olamin, -Kalium, – Natrium und -Trolamin, MCPB, MCPB-Methyl, -Ethyl und -Natrium, Mecoprop, Mecoprop-Butotyl, Mecoprop- dimethylammonium, Mecoprop-Diolamin, Mecoprop-Etexyl, Mecoprop-Ethadyl, Mecoprop-Isoctyl, Mecoprop-Methyl, Mecoprop-Kalium, Mecoprop-Natrium, und Mecoprop- Trolamin, Mecoprop-P, Mecoprop-P-Butotyl, -Dimethylammonium, -2-Ethylhexyl und -Kalium, Mefenacet, Mefluidid, Mefluidid-Diolamin, Mefluidid-Kalium, Mesosulfuron, Mesosulfuron-Methyl, Mesosulfuron-Natrium, Mesotrion, Methabenzthiazuron, Metam, Metamifop, Metamitron, Metazachlor, Metazosulfuron, Methabenzthiazuron, Methiopyrsulfuron, Methiozolin, Methyl isothiocyanat, Metobromuron, Metolachlor, S-Metolachlor, Metosulam, Metoxuron, Metribuzin, Metsulfuron, Metsulfuron-Methyl, Molinat, Monolinuron, Monosulfuron, Monosulfuron-Methyl, MT- 5950, i.e. N-[3-Chlor-4-(1-methylethyl)-phenyl]-2-methylpentanamid, NGGC-011, Napropamid, NC- 310, i.e.4-(2,4-Dichlorbenzoyl)-1-methyl-5-benzyloxypyrazol, NC-656, i.e. 3- [(Isopropylsulfonyl)methyl]-N-(5-methyl-1,3,4-oxadiazol-2-yl )-5-(trifluormethyl)[1,2,4]triazolo-[4,3- a]pyridin-8-carboxamid, Neburon, Nicosulfuron, Nonansäure (Pelargonsäure), Norflurazon, Ölsäure (Fettsäuren), Orbencarb, Orthosulfamuron, Oryzalin, Oxadiargyl, Oxadiazon, Oxasulfuron, Oxaziclomefone, Oxyfluorfen, Paraquat, Paraquat-dichlorid, Paraquat-Dimethylsulfat, Pebulat, Pendimethalin, Penoxsulam, Pentachlorphenol, Pentoxazon, Pethoxamid, Petroleumöl, Phenmedipham, Phenmedipham-Ethyl, Picloram, Picloram-dimethylammonium, Picloram-Etexyl, Picloram-Isoctyl, Picloram-Methyl, Picloram-Olamin, Picloram-Kalium, Picloram-Triethylammonium, Picloram- Tripromin, Picloram-Trolamin, Picolinafen, Pinoxaden, Piperophos, Pretilachlor, Primisulfuron, Primisulfuron-Methyl, Prodiamine, Profoxydim, Prometon, Prometryn, Propachlor, Propanil, Propaquizafop, Propazine, Propham, Propisochlor, Propoxycarbazone, Propoxycarbazone-Natrium, Propyrisulfuron, Propyzamid, Prosulfocarb, Prosulfuron, Pyraclonil, Pyraflufen, Pyraflufen-Ethyl, Pyrasulfotol, Pyrazolynat (Pyrazolat), Pyrazosulfuron, Pyrazosulfuron-Ethyl, Pyrazoxyfen, Pyribambenz, Pyribambenz-Isopropyl, Pyribambenz-Propyl, Pyribenzoxim, Pyributicarb, Pyridafol, Pyridat, Pyriftalid, Pyriminobac, Pyriminobac-Methyl, Pyrimisulfan, Pyrithiobac, Pyrithiobac-Natrium, Pyroxasulfon, Pyroxsulam, Quinclorac, Quinclorac-Dimethylammonium, Quinclorac-Methyl, Quinmerac, Quinoclamin, Quizalofop, Quizalofop-Ethyl, Quizalofop-P, Quizalofop-P-Ethyl, Quizalofop-P-Tefuryl, QYM201, i.e.1-{2-Chlor-3-[(3-cyclopropyl-5-hydroxy-1-methyl-1H-pyraz ol-4- yl)carbonyl]-6-(trifluormethyl)phe-nyl}piperidin-2-on, Rimsulfuron, Saflufenacil, Sethoxydim, Siduron, Simazine, Simetryn, SL-261, Sulcotrione, Sulfentrazone, Sulfometuron, Sulfometuron-Methyl, Sulfosulfuron, , SYP-249, i.e.1-Ethoxy-3-methyl-1-oxobut-3-en-2-yl-5-[2-chlor-4- (trifluormethyl)phenoxy]-2-nitrobenzoat, SYP-300, i.e.1-[7-Fluor-3-oxo-4-(prop-2-in-1-yl)-3,4- dihydro-2H-1,4-benzoxazin-6-yl]-3-propyl-2-thioxoimidazolidi n-4,5-dion, 2,3,6-TBA, TCA (Trichloressigsäure) und seine Salze, z.B. TCA-ammonium, TCA-Calcium, TCA-Ethyl, TCA- Magnesium, TCA-Natrium, Tebuthiuron, Tefuryltrione, Tembotrion, Tepraloxydim, Terbacil, Terbucarb, Terbumeton, Terbuthylazine, Terbutryn, Tetflupyrolimet, Thaxtomin, Thenylchlor, Thiazopyr, Thiencarbazone, Thiencarbazon-Methyl, Thifensulfuron, Thifensulfuron-Methyl, Thiobencarb, Tiafenacil, Tolpyralat, Topramezon, Tralkoxydim, Triafamon, Tri-allat, Triasulfuron, Triaziflam, Tribenuron, Tribenuron-Methyl, Triclopyr, Triclopyr-Butotyl, Triclopyr-Cholin, Triclopyr- Ethyl, Triclopyr-Triethylammonium, Trietazine, Trifloxysulfuron, Trifloxysulfuron-Natrium, Trifludimoxazin, Trifluralin, Triflusulfuron, Triflusulfuron-Methyl, Tritosulfuron, Harnstoffsulfat, Vernolat, XDE-848, ZJ-0862, i.e.3,4-Dichlor-N-{2-[(4,6-dimethoxypyrimidin-2-yl)oxy]benzy l}anilin, 3-(2-Chlor-4-fluor-5-(3-methyl-2,6-dioxo-4-trifluormethyl-3, 6-dihydropyrimidin-1(2H)-yl)phenyl)-5- methyl-4,5-dihydroisoxazole-5-carbonsäureethylester, Ethyl-[(3-{2-chlor-4-fluor-5-[3-methyl-2,6- dioxo-4-(trifluormethyl)-3,6-dihydropyrimidin-1(2H)-yl]pheno xy}pyridin-2-yl)oxy]acetat, 3-Chlor-2- [3-(difluormethyl)isoxazolyl-5-yl]phenyl-5-chlorpyrimidin-2- ylether, 2-(3,4-Dimethoxyphenyl)-4-[(2- hydroxy-6-oxocyclohex-1-en-1-yl)carbonyl]-6-methylpyridazine -3(2H)-on, 2-({2-[(2- Methoxyethoxy)methyl]-6-methylpyridin-3-yl}carbonyl)cyclohex ane-1,3-dion, (5-Hydroxy-1-methyl- 1H-pyrazol-4-yl)(3,3,4-trimethyl-1,1-dioxido-2,3-dihydro-1-b enzothiophen-5-yl)methanon, 1-Methyl-4- [(3,3,4-trimethyl-1,1-dioxido-2,3-dihydro-1-benzothiophen-5- yl)carbonyl]-1H-pyrazol-5-yl propan-1- sulfonat, 4-{2-Chlor-3-[(3,5-dimethyl-1H-pyrazol-1-yl)methyl]-4-(methy lsulfonyl)benzoyl}-1-methyl- 1H-pyrazol-5-yl-1,3-dimethyl-1H-pyrazole-4-carboxylat; Cyanomethyl-4-amino-3-chlor-5-fluor-6-(7- fluor-1H-indol-6-yl)pyridine-2-carboxylat, Prop-2-yn-1-yl 4-amino-3-chlor-5-fluor-6-(7-fluor-1H-indol- 6-yl)pyridine-2-carboxylat, Methyl-4-amino-3-chlor-5-fluor-6-(7-fluor-1H-indol-6-yl)pyri dine-2- carboxylat, 4-Amino-3-chlor-5-fluor-6-(7-fluor-1H-indol-6-yl)pyridine-2- carbonsäure, Benzyl-4-amino- 3-chlor-5-fluor-6-(7-fluor-1H-indol-6-yl)pyridine-2-carboxyl at, Ethyl-4-amino-3-chlor-5-fluor-6-(7- fluor-1H-indol-6-yl)pyridine-2-carboxylat, Methyl-4-amino-3-chlor-5-fluor-6-(7-fluor-1-isobutyryl-1H- indol-6-yl)pyridine-2-carboxylat, Methyl 6-(1-acetyl-7-fluor-1H-indol-6-yl)-4-amino-3-chlor-5- fluorpyridine-2-carboxylat, Methyl-4-amino-3-chlor-6-[1-(2,2-dimethylpropanoyl)-7-fluor- 1H-indol-6- yl]-5-fluorpyridine-2-carboxylat, Methyl-4-amino-3-chlor-5-fluor-6-[7-fluor-1-(methoxyacetyl)- 1H- indol-6-yl]pyridine-2-carboxylat, Kalium 4-amino-3-chlor-5-fluor-6-(7-fluor-1H-indol-6-yl)pyridine-2- carboxylat, Natrium-4-amino-3-chlor-5-fluor-6-(7-fluor-1H-indol-6-yl)pyr idine-2-carboxylat, Butyl-4- amino-3-chlor-5-fluor-6-(7-fluor-1H-indol-6-yl)pyridine-2-ca rboxylat, 4-Hydroxy-1-methyl-3-[4- (trifluormethyl)pyridin-2-yl]imidazolidin-2-one, 3-(5-tert-butyl-1,2-oxazol-3-yl)-4-hydroxy-1- methylimidazolidin-2-on, 3-[5-Chlor-4-(trifluormethyl)pyridin-2-yl]-4-hydroxy-1-methy limidazolidin- 2-on, 4-Hydroxy-1-methoxy-5-methyl-3-[4-(trifluormethyl)pyridin-2- yl]imidazolidin-2-on, 6-[(2- Hydroxy-6-oxocyclohex-1-en-1-yl)carbonyl]-1,5-dimethyl-3-(2- methylphenyl)chinazolin-2,4(1H,3H)- dion, 3-(2,6-Dimethylphenyl)-6-[(2-hydroxy-6-oxocyclohex-1-en-1-yl )carbonyl]-1-methylchinazolin- 2,4(1H,3H)-dion, 2-[2-chlor-4-(methylsulfonyl)-3-(morpholin-4-ylmethyl)benzoy l]-3-hydroxycyclohex- 2-en-1-on, 1-(2-carboxyethyl)-4-(pyrimidin-2-yl)pyridazin-1-iumsalz (mit passenden Anionen wie z.B Chlorid, Acetat oder Trifluoracetat), 1-(2-carboxyethyl)-4-(pyridazin-3-yl)pyridazin-1-iumsalz (mit passenden Anionen wie z.B. Chlorid, Acetat oder Trifluoracetat), 4-(Pyrimidin-2-yl)-1-(2- sulfoethyl)pyridazin-1-ium salz iumsalz (mit passenden Anionen wie z.B Chlorid, Acetat oder Trifluoracetat), 4-(Pyridazin-3-yl)-1-(2-sulfoethyl)pyridazin-1-ium salz iumsalz (mit passenden Anionen wie z.B Chlorid, Acetat oder Trifluoracetat). Die Erfindung soll durch die nachfolgenden biologischen Beispiele veranschaulicht werden, ohne sie jedoch darauf einzuschränken. In vivo-Analysen – Teil A Samen von mono- bzw. dikotylen Kulturpflanzen wurden in Holzfaser- oder Plastiktöpfen in sandigem Lehmboden ausgesät, mit Erde oder Sand abgedeckt und im Gewächshaus unter guten Wachstumsbedingungen angezogen. Die Behandlung der Versuchspflanzen erfolgte im frühen Laubblattstadium (BBCH10 – BBCH13). Zur Gewährleistung einer uniformen Wasserversorgung vor Stressbeginn wurden die bepflanzten Töpfe vor Substanzapplikation durch Anstaubewässerung mit Wasser versorgt. Die in Form von benetzbaren Pulvern (WP) formulierten erfindungsgemäßen Verbindungen wurden als wässrige Suspension mit einer Wasseraufwandmenge von umgerechnet 600 l/ha unter Zusatz von 0,2% Netzmittel (z.B. Agrotin) auf die grünen Pflanzenteile gesprüht. Unmittelbar nach Substanzapplikation erfolgte die Stressbehandlung der Pflanzen. Die Holzfasertöpfe wurden dazu in Plastikeinsätze transferiert, um anschließendes, zu schnelles Abtrocknen zu verhindern. Der Trockenstress wurde durch langsames Abtrocknen unter folgenden Bedingungen induziert: „Tag“: 14 Stunden beleuchtet bei ~ 26-30°C „Nacht“: 10 Stunden ohne Beleuchtung bei ~ 18-20°C. Die Dauer der jeweiligen Stressphasen richtete sich hauptsächlich nach dem Zustand der gestressten Kontrollpflanzen. Sie wurde (durch Wiederbewässerung und Transfer in ein Gewächshaus mit guten Wachstumsbedingungen) beendet, sobald irreversible Schäden an den gestressten Kontrollpflanzen zu beobachten waren. Nach Beendigung der Stressphase folgte eine ca.4-7 tägige Erholungsphase, während der die Pflanzen abermals unter guten Wachstumsbedingungen im Gewächshaus gehalten wurden. Die Dauer der Erholungsphase richtete sich hauptsächlich danach, wann die Versuchspflanzen einen Zustand erreicht hatten, der eine visuelle Bonitur potenzieller Effekte ermöglichte, und ist daher variabel. Wenn dieser Zeitpunkt erreicht war, wurden die Schadintensitäten visuell im Vergleich zu unbehandelten, ungestressten Kontrollen gleichen Alters bonitiert. Die Erfassung der Schadintensität erfolgte zunächst in Prozent. Aus diesen Werten wurde sodann der Wirkungsgrad der Testverbindungen nachfolgender Formel ermittelt: WG: Wirkungsgrad (Efficacy) SI s : Schadintensität der gestressten Kontrollpflanzen SI t : Schadintensität der mit Testverbindung behandelten, gestressten Pflanzen Bei den in untenstehenden Tabellen A-1 bis A-3 angegebenen Werten handelt es sich um Mittelwerte aus mindestens einem Versuch mit mindestens zwei Replikaten, wobei die Wirkungen ausgewählter Verbindungen der allgemeinen Formel (I) unter Trockenstress auf verschiedene Kulturpflanzen dargestellt sind. Tabelle A-1

Tabelle A-2 Tabelle A-3 In vivo-Analysen – Teil B Samen von mono- bzw. dikotylen Kulturpflanzen wurden in Plastiktöpfen in sandigem Lehmboden ausgesät, mit Erde oder Sand abgedeckt und im Gewächshaus unter guten Wachstumsbedingungen angezogen. Die Behandlung der Versuchspflanzen erfolgt im frühen Laubblattstadium (BBCH10 – BBCH13). Zur Gewährleistung einer uniformen Wasserversorgung vor Stressbeginn wurden die bepflanzten Töpfe vor Substanzapplikation durch Anstaubewässerung mit Wasser versorgt. Die erfindungsgemäßen Verbindungen wurden zunächst als benetzbare Pulver (WP) formuliert oder in einem Lösungsmittelgemisch gelöst. Die weitere Verdünnung erfolgte mit Wasser unter Zusatz von 0,2% Netzmittel (z.B. Agrotin). Die fertige Spritzbrühe wurde mit einer Wasseraufwandmenge von umgerechnet 600 l/ha auf die grünen Pflanzenteile gesprüht. Unmittelbar nach Substanzapplikation erfolgte die Stressbehandlung der Pflanzen. Der Trockenstress wurde durch langsames Abtrocknen unter folgenden Bedingungen induziert: „Tag“: 14 Stunden beleuchtet bei ~ 26-30°C „Nacht“: 10 Stunden ohne Beleuchtung bei ~ 18-20°C. Die Dauer der jeweiligen Stressphasen richtete sich hauptsächlich nach dem Zustand der gestressten Kontrollpflanzen. Sie wurde (durch Wiederbewässerung und Transfer in ein Gewächshaus mit guten Wachstumsbedingungen) beendet, sobald irreversible Schäden an den gestressten Kontrollpflanzen zu beobachten waren. Nach Beendigung der Stressphase folgte eine ca.4-7 tägige Erholungsphase, während der die Pflanzen abermals unter guten Wachstumsbedingungen im Gewächshaus gehalten wurden. Die Dauer der Erholungsphase richtete sich hauptsächlich danach, wann die Versuchspflanzen einen Zustand erreicht hatten, der eine visuelle Bonitur potenzieller Effekte ermöglichte, und war daher variabel. Wenn dieser Zeitpunkt erreicht war, wurde das Erscheinungsbild der mit Testsubstanzen behandelten Pflanzen im Vergleich zu den gestressten Kontrollpflanzen nachfolgenden Kategorien erfasst: 0 kein positiver Effekt + leicht positiver Effekt ++ deutlich positiver Effekt +++ stark positiver Effekt Um auszuschließen, dass die beobachteten Effekte von der ggf. fungiziden oder insektiziden Wirkung der Testverbindungen beeinflusst wurden, wurde zudem darauf geachtet, dass die Versuche ohne Pilzinfektion oder Insektenbefall abliefen. Bei den in den untenstehenden Tabellen B-1 und B-2 angegebenen Werten handelt es sich um Mittelwerte der Ergebnisse aus mindestens drei Replikaten. Wirkungen ausgewählter Verbindungen der allgemeinen Formel (I) unter Trockenstress gemäß nachstehender Tabellen B-1 und B-2: Tabelle B-1 Tabelle B-2

In den zuvor genannten Tabellen bedeuten: BRSNS = Brassica napus ZEAMX = Zea mays TRZAS = Triticum aestivum




 
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