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Title:
THE USE OF SUCCINATE DERIVATIVE ESTERS FOR THE TREATMENT OF DEMENTIA
Document Type and Number:
WIPO Patent Application WO/2004/058244
Kind Code:
A1
Abstract:
The use of extract form Wangla (coeloglossum viride (L) Hartm. Var. Bracteatum (Willd.) Richter), succinate derivative esters, and a derivative and pharmaceutical acceptable salts thereof, for the manufacture of a pharmaceutical preparation for the treatment of dementia, particularly for the treatment of Alzheimer’ disease and Vascular dementia. Through Animal experiment, it has been demonstrated that, succinate derivative esters can improve learning and memory ability in dementia rats induced by scopolamine and cyclohexenyl imine; improve learning and memory ability in dementia rats induced by β-amyloid; improve learning and memory ability in dementia rats induced by permanent ligation of bilateral carotid; and improve memory ability of normal animals. It has the advantage of high activity, low toxicity and no inhibition to cholinesterase.

Inventors:
ZHANG JIANJUN (CN)
SHI JIANGONG (CN)
WANG YAFANG (CN)
ZHANG DAN (CN)
GAO MEI (CN)
YANG YONGCHUN (CN)
HUANG SHENGYANG (CN)
Application Number:
PCT/CN2003/001155
Publication Date:
July 15, 2004
Filing Date:
December 31, 2003
Export Citation:
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Assignee:
INST MATERIA MEDICA CAMS (CN)
ZHANG JIANJUN (CN)
SHI JIANGONG (CN)
WANG YAFANG (CN)
ZHANG DAN (CN)
GAO MEI (CN)
YANG YONGCHUN (CN)
HUANG SHENGYANG (CN)
International Classes:
A61K31/194; A61K31/222; A61K31/7012; A61K31/7028; A61P25/28; (IPC1-7): A61K31/222; A61K31/194; A61K31/7012; A61K31/7028; A61P25/28
Foreign References:
Other References:
SHENGYANG HUANG ET AL.: "Studies on the chemical constituents of Coeloglossum viride (L.) hartm. ar. Bracteatum (wild.) Rchter.", ACTA PHARMACEUTICA SINICA, vol. 37, no. 3, March 2002 (2002-03-01), pages 199 - 203, XP008099998
SHENGYANG HUANG ET AL.: "Studies on the chemical constituents of tibetan medicine Wangka (Rhizome of Coeloglossum viride Var. Bracteatum)", CHINA JOURNAL OF CHINESE MATERIA MEDICA, vol. 27, no. 2, February 2002 (2002-02-01), pages 551 - 554, XP008100655
SHENGYANG HUANG ET AL.: "Two new isobutyltartrate monoesters from Coeloglossum viride (L) Hartm. Var. Bracteatum (willd.) Richter.", CHINESE CHEMICAL LETTERS, vol. 13, no. 6, June 2002 (2002-06-01), pages 551 - 554, XP008100681
KIZU HARUHISA ET AL.: "Studies on nepalese crude drugs. XXVI. Chemical constituents of panch aunle, the roots of dactylorhiza hatagirea D", DON. CHEM. PHARM. BULL., vol. 47, no. 11, November 1999 (1999-11-01), pages 1618 - 1625, XP008131509
GRAY ROBERT W. ET AL.: "Die konstitution des loroglossins", HELV. CHEM. ACTA, vol. 60, no. 4, April 1977 (1977-04-01), pages 1305, XP008102768
See also references of EP 1582209A4
Attorney, Agent or Firm:
CCPIT PATENT AND TRADEMARK LAW OFFICE (Vantone New World Plaza 2 Fuchengmenwai Street, Beijing 7, CN)
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