Title:
USE OF SWIM-BLADDER-DERIVED HEPARIN MUCOPOLYSACCHARIDE IN PREPARATION OF ANGIOGENESIS INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2022/062101
Kind Code:
A1
Abstract:
Provided is the use of a swim-bladder-derived heparin mucopolysaccharide in the preparation of an angiogenesis inhibitor, which use relates to the technical field of medicine. The swim-bladder-derived heparin mucopolysaccharide has the structural unit of α-ΔGlcUA-[1→3]-GalNAc-4S, and has a strong inhibition effect on angiogenesis. 400 mg/L of the swim-bladder-derived heparin mucopolysaccharide can achieve an inhibition rate of 90.3% for the growth of human umbilical vein vascular endothelial cells; and 1 mg/mL of the swim-bladder-derived heparin mucopolysaccharide has an inhibition rate of 77.15% for the angiogenesis of chicken embryo allantoic membranes.
Inventors:
ZHONG SAIYI (CN)
ZHOU SIYI (CN)
CHEN JING (CN)
CHEN JIANPING (CN)
CHEN SUHUA (CN)
LI RUI (CN)
JIA XUEJING (CN)
LIU XIAOFEI (CN)
ZHOU SIYI (CN)
CHEN JING (CN)
CHEN JIANPING (CN)
CHEN SUHUA (CN)
LI RUI (CN)
JIA XUEJING (CN)
LIU XIAOFEI (CN)
Application Number:
PCT/CN2020/127708
Publication Date:
March 31, 2022
Filing Date:
November 10, 2020
Export Citation:
Assignee:
UNIV GUANGDONG OCEAN (CN)
SHENZHEN INSTITUTE OF GUANGDONG OCEAN UNIV (CN)
SHENZHEN INSTITUTE OF GUANGDONG OCEAN UNIV (CN)
International Classes:
A61K35/60; A61K31/727; A61P43/00; C08B37/00
Domestic Patent References:
| WO2011122321A1 | 2011-10-06 |
Foreign References:
| CN109251255A | 2019-01-22 | |||
| CN106967186A | 2017-07-21 | |||
| JP2017081851A | 2017-05-18 |
Other References:
ZHOU SIYI, ZHONG SAIYI;SU WEIMING;DU ZHENXING;CHEN JIANPING;HONG PENGZHI;ZHANG CHAOHUA: "Isolation, Purification and Structural Identification of Heparinoids from Fish Swim Bladder", FOOD SCIENCE, BEIJING FOOD SCIENCE RESEARCH INSTITUTE, CN, vol. 40, no. 15, 31 December 2019 (2019-12-31), CN , pages 84 - 91, XP055913562, ISSN: 1002-6630, DOI: 10.7506/spkx1002-6630-20180728-351
LIU, Y. ; YANG, H. ; OTAKA, K. ; TAKATSUKI, H. ; SAKANISHI, A.: "Effects of vascular endothelial growth factor (VEGF) and chondroitin sulfate A on human monocytic THP-1 cell migration", COLLOIDS AND SURFACES B: BIOINTERFACES, ELSEVIER AMSTERDAM, NL, vol. 43, no. 3-4, 10 July 2005 (2005-07-10), NL , pages 216 - 220, XP027803485, ISSN: 0927-7765
PALHARES LAIS C.G.F. ET AL.,: "In vitro antitumor and anti-angiogenic activities of a shrimp chondroitin sulfate,", INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,, vol. 162, 15 June 2020 (2020-06-15), XP086280576, DOI: 10.1016/j.ijbiomac.2020.06.100
ZHOU SIYI, QU YI;ZHONG SAI-YI;DU ZHEN-XING;SU WEI-MIN;CHEN SU-HUA;HONG PENG-ZHI;WU XIAO-HE: "Optimization of Extraction Process of Heparinoid From Swim Bladder and Evaluation Its Anticoagulant Activity", SHIPIN YU JIXIE - FOOD AND MACHINERY, GAI KAN BIANJIBU, CHANGSHA, CN, vol. 34, no. 7, 31 July 2018 (2018-07-31), CN , XP055913564, ISSN: 1003-5788, DOI: 10.13652/j.issn.1003-5788.2018.07.032
LIU, Y. ; YANG, H. ; OTAKA, K. ; TAKATSUKI, H. ; SAKANISHI, A.: "Effects of vascular endothelial growth factor (VEGF) and chondroitin sulfate A on human monocytic THP-1 cell migration", COLLOIDS AND SURFACES B: BIOINTERFACES, ELSEVIER AMSTERDAM, NL, vol. 43, no. 3-4, 10 July 2005 (2005-07-10), NL , pages 216 - 220, XP027803485, ISSN: 0927-7765
PALHARES LAIS C.G.F. ET AL.,: "In vitro antitumor and anti-angiogenic activities of a shrimp chondroitin sulfate,", INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,, vol. 162, 15 June 2020 (2020-06-15), XP086280576, DOI: 10.1016/j.ijbiomac.2020.06.100
ZHOU SIYI, QU YI;ZHONG SAI-YI;DU ZHEN-XING;SU WEI-MIN;CHEN SU-HUA;HONG PENG-ZHI;WU XIAO-HE: "Optimization of Extraction Process of Heparinoid From Swim Bladder and Evaluation Its Anticoagulant Activity", SHIPIN YU JIXIE - FOOD AND MACHINERY, GAI KAN BIANJIBU, CHANGSHA, CN, vol. 34, no. 7, 31 July 2018 (2018-07-31), CN , XP055913564, ISSN: 1003-5788, DOI: 10.13652/j.issn.1003-5788.2018.07.032
Attorney, Agent or Firm:
BEIJING GAOWO LAW FIRM (CN)
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