Title:
USE OF TERPENE COMPOUNDS FOR REDUCED RELEASE OF ARACHIDONIC ACID AND OF INFLAMMATION MEDIATORS
Document Type and Number:
WIPO Patent Application WO1994028895
Kind Code:
A3
Abstract:
PCT No. PCT/EP94/01900 Sec. 371 Date Feb. 23, 1995 Sec. 102(e) Date Feb. 23, 1995 PCT Filed Jun. 11, 1994 PCT Pub. No. WO94/28895 PCT Pub. Date Dec. 22, 1994Disclosed is a method of treatment of steroid requiring inflammatory diseases using certain saturated monocyclic and bicyclic terpene compounds. These compounds may be administered in the form of capsules resistant to gastric juice, infusion solutions or intramuscular injection solutions. Because these particular terpene compounds exhibit steroid-like effects but without the harmful side-effects of conventional corticosteroids, the use of corticosteroids is substantially reduced, and in some cases, completely eliminated. Therefore, these terpene compounds are also suitable for long-term therapy and prophylaxis.
Inventors:
JUERGENS UWE R (DE)
Application Number:
PCT/EP1994/001900
Publication Date:
April 06, 1995
Filing Date:
June 11, 1994
Export Citation:
Assignee:
JUERGENS UWE R (DE)
International Classes:
A61K9/08; A61K9/48; A61K31/045; C07D311/00; A61K31/05; A61K31/085; A61K31/10; A61K31/12; A61K31/35; A61K31/352; A61K31/405; A61K31/57; A61K31/573; A61P1/16; A61P3/06; A61P9/00; A61P11/00; A61P13/02; A61P15/00; A61P29/00; A61P37/00; A61P37/08; A61P43/00; (IPC1-7): A61K31/405; A61K31/35; A61K31/605
Foreign References:
| US4775667A | 1988-10-04 |
Other References:
DATABASE MEDLINE US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; June 1991 (1991-06-01), N. SIDELL ET AL.: "Retinoic acid-induced growth inhibition of a human myeloma cell line via down-regulation of Il-6 receptors"
H. GRIMM: "Antiobstruktive Wirksamkeit von Cineol bei Atemwegserkrankungen", THERAPIEWOCHE, vol. 37, no. 45, 1987, pages 4306 - 4311
F. DEWHIRST: "Structure-activity relationshipsfor inhibition of prostaglandin cyclooxygenase by phenolic compounds", PROSTAGLANDINS, vol. 20, no. 2, 1980, pages 204 - 222, XP000654642
DATABASE WPI Section Ch Week 9211, Derwent World Patents Index; Class B05, AN 92-084354
BUNDESVERBAND DER PHARMAZEUTISCHEN INDUSTRIE E.V.: "rote liste 1992", 1992, EDITIO CANTOR, AULENDORF/BRD
H. GRIMM: "Antiobstruktive Wirksamkeit von Cineol bei Atemwegserkrankungen", THERAPIEWOCHE, vol. 37, no. 45, 1987, pages 4306 - 4311
F. DEWHIRST: "Structure-activity relationshipsfor inhibition of prostaglandin cyclooxygenase by phenolic compounds", PROSTAGLANDINS, vol. 20, no. 2, 1980, pages 204 - 222, XP000654642
DATABASE WPI Section Ch Week 9211, Derwent World Patents Index; Class B05, AN 92-084354
BUNDESVERBAND DER PHARMAZEUTISCHEN INDUSTRIE E.V.: "rote liste 1992", 1992, EDITIO CANTOR, AULENDORF/BRD
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