Title:
USE OF THIAZOLYLDIAZONAPHTHOL COMPOUND IN PREPARATION OF DRUG FOR TREATING GLIOBLASTOMA
Document Type and Number:
WIPO Patent Application WO/2023/024337
Kind Code:
A1
Abstract:
The use of a thiazolyldiazonaphthol compound represented by formula I or a pharmaceutically acceptable salt thereof in the preparation of a drug for treating glioblastoma (GBM), in formula I, R1, R2, R3, R4, R5, and R6 being selected from H or C1
-
5alkyl groups. The drug prepared from the thiazolyldiazonaphthol compound represented by formula I or the pharmaceutically acceptable salt thereof has small side effects, high targeting performance, and no obvious systemic toxicity, and can effectively inhibit and kill GBM cells, and has important prospects in the direction of chemotherapeutic drugs for GBM.
Inventors:
CHANG JUNLEI (CN)
YU MIN (CN)
HU XIAOYAN (CN)
YANG SHILUN (CN)
YU MIN (CN)
HU XIAOYAN (CN)
YANG SHILUN (CN)
Application Number:
PCT/CN2021/137746
Publication Date:
March 02, 2023
Filing Date:
December 14, 2021
Export Citation:
Assignee:
SHENZHEN INST ADV TECH (CN)
International Classes:
A61K31/426; A61K45/06; A61P35/00
Foreign References:
| CN113616645A | 2021-11-09 | |||
| CN106459601A | 2017-02-22 | |||
| US20180169074A1 | 2018-06-21 |
Other References:
YU MIN, HU XIAOYAN, YAN JINGYU, WANG YING, LU FEI, CHANG JUNLEI: "RIOK2 Inhibitor NSC139021 Exerts Anti-Tumor Effects on Glioblastoma via Inducing Skp2-Mediated Cell Cycle Arrest and Apoptosis", BIOMEDICINES, vol. 9, no. 9, 1 January 2021 (2021-01-01), pages 1244 - 86, XP093038527, DOI: 10.3390/biomedicines9091244
AHMED A. MOHAMED, CHARLES P XAVIER, GAUTHAMAN SUKUMAR, SHYH-HAN TAN, LAKSHMI RAVINDRANATH, NISHAT SERAJ, VINEET KUMAR, TADURU L SR: "Identification of a small molecule that selectively inhibits ERG-positive cancer cell growth", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, US, pages canres.2949.2017, XP055677968, ISSN: 0008-5472, DOI: 10.1158/0008-5472.CAN-17-2949
READ RENEE D., FENTON TIM R., GOMEZ GERMAN G., WYKOSKY JILL, VANDENBERG SCOTT R., BABIC IVAN, IWANAMI AKIO, YANG HUIJUN, CAVENEE W: "A Kinome-Wide RNAi Screen in Drosophila Glia Reveals That the RIO Kinases Mediate Cell Proliferation and Survival through TORC2-Akt Signaling in Glioblastoma", PLOS GENETICS, vol. 9, no. 2, 14 February 2013 (2013-02-14), pages e1003253, XP093038524, DOI: 10.1371/journal.pgen.1003253
HSING MICHAEL, WANG YUZHUO, RENNIE PAUL S., COX MICHAEL E., CHERKASOV ARTEM: "ETS transcription factors as emerging drug targets in cancer", MEDICINAL RESEARCH REVIEWS, WILEY SUBSCRIPTION SERVICES, INC., A WILEY COMPANY, US, vol. 40, no. 1, 1 January 2020 (2020-01-01), US , pages 413 - 430, XP093038519, ISSN: 0198-6325, DOI: 10.1002/med.21575
SONG YUNNONG, LI CHENG, JIN LEI, XING JINGSONG, SHA ZHUANG, ZHANG TONG, JI DAOFEI, YU RUTONG, GAO SHANGFENG: "RIOK2 is negatively regulated by miR‐4744 and promotes glioma cell migration/invasion through epithelial‐mesenchymal transition", JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, UNIVERSITY PRESS CAROL DAVILA, BUCHAREST, RO, vol. 24, no. 8, 1 April 2020 (2020-04-01), RO , pages 4494 - 4509, XP093038518, ISSN: 1582-1838, DOI: 10.1111/jcmm.15107
AHMED A. MOHAMED, CHARLES P XAVIER, GAUTHAMAN SUKUMAR, SHYH-HAN TAN, LAKSHMI RAVINDRANATH, NISHAT SERAJ, VINEET KUMAR, TADURU L SR: "Identification of a small molecule that selectively inhibits ERG-positive cancer cell growth", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, US, pages canres.2949.2017, XP055677968, ISSN: 0008-5472, DOI: 10.1158/0008-5472.CAN-17-2949
READ RENEE D., FENTON TIM R., GOMEZ GERMAN G., WYKOSKY JILL, VANDENBERG SCOTT R., BABIC IVAN, IWANAMI AKIO, YANG HUIJUN, CAVENEE W: "A Kinome-Wide RNAi Screen in Drosophila Glia Reveals That the RIO Kinases Mediate Cell Proliferation and Survival through TORC2-Akt Signaling in Glioblastoma", PLOS GENETICS, vol. 9, no. 2, 14 February 2013 (2013-02-14), pages e1003253, XP093038524, DOI: 10.1371/journal.pgen.1003253
HSING MICHAEL, WANG YUZHUO, RENNIE PAUL S., COX MICHAEL E., CHERKASOV ARTEM: "ETS transcription factors as emerging drug targets in cancer", MEDICINAL RESEARCH REVIEWS, WILEY SUBSCRIPTION SERVICES, INC., A WILEY COMPANY, US, vol. 40, no. 1, 1 January 2020 (2020-01-01), US , pages 413 - 430, XP093038519, ISSN: 0198-6325, DOI: 10.1002/med.21575
SONG YUNNONG, LI CHENG, JIN LEI, XING JINGSONG, SHA ZHUANG, ZHANG TONG, JI DAOFEI, YU RUTONG, GAO SHANGFENG: "RIOK2 is negatively regulated by miR‐4744 and promotes glioma cell migration/invasion through epithelial‐mesenchymal transition", JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, UNIVERSITY PRESS CAROL DAVILA, BUCHAREST, RO, vol. 24, no. 8, 1 April 2020 (2020-04-01), RO , pages 4494 - 4509, XP093038518, ISSN: 1582-1838, DOI: 10.1111/jcmm.15107
Attorney, Agent or Firm:
BEIJING ZHONG XUN TONG DA INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)
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