Title:
USE OF TRIACETYL-3-HYDROXYPHENYLADENOSINE IN PREPARING PHARMACEUTICALS FOR TREATMENT OF ATHEROSCLEROSIS
Document Type and Number:
WIPO Patent Application WO/2017/157248
Kind Code:
A1
Abstract:
Provided are uses of an adenosine derivative, shown in formula (I), in preparing pharmaceuticals for the prevention and/or treatment of hyperlipidemia-induced monocytosis, and for the prevention and/or treatment of atherosclerosis. The prevention and/or treatment of atherosclerosis refers to the prevention and/or treatment of atherosclerosis-induced inflammatory monocytosis.
Inventors:
ZHU HAIBO (CN)
WANG JING (CN)
WANG JING (CN)
Application Number:
PCT/CN2017/076304
Publication Date:
September 21, 2017
Filing Date:
March 10, 2017
Export Citation:
Assignee:
JIANGSU TASLY DIYI PHARMACEUTICAL CO LTD (CN)
INST MATERIA MEDICA CAMS (CN)
INST MATERIA MEDICA CAMS (CN)
International Classes:
A61K31/7076; A61P9/10; A61P29/00
Foreign References:
| CN102125580A | 2011-07-20 | |||
| CN101712709A | 2010-05-26 | |||
| CN104546887A | 2015-04-29 |
Other References:
WANG, JING ET AL.: "AMPK reduces hypercholesterolemia-associated monocytosis and reduce macrophages in atheromata", PROCEEDINGS OF THE FOURTEEN CHINA PHARMACISTS WEEK AND 2014TH CHINESE PHARMACEUTICAL CONFERENCE, 25 October 2014 (2014-10-25), pages 1 - 3, XP009515402
LIAN, ZEQIN ET AL.: "Target validation on blood-lipid regulation drug candidate target using metabonomics and virtual molecular docking", CHINESE JOURNAL OF PHARMACOLOGY AND TOXICOLOGY, vol. 25, no. Suppl., 23 September 2011 (2011-09-23), CN, pages 131, XP009512526, ISSN: 1000-3002
LI WEI; ZHU HAIBO: "Study on instantaneous weak interaction between a new structure type blood-lipid regulation compound and a target protein", CHINESE JOURNAL OF PHARMACOLOGY AND TOXICOLOGY, vol. 25, no. Suppl., 23 September 2011 (2011-09-23), pages 131 - 132, XP009512527, ISSN: 1000-3002
See also references of EP 3431091A4
LIAN, ZEQIN ET AL.: "Target validation on blood-lipid regulation drug candidate target using metabonomics and virtual molecular docking", CHINESE JOURNAL OF PHARMACOLOGY AND TOXICOLOGY, vol. 25, no. Suppl., 23 September 2011 (2011-09-23), CN, pages 131, XP009512526, ISSN: 1000-3002
LI WEI; ZHU HAIBO: "Study on instantaneous weak interaction between a new structure type blood-lipid regulation compound and a target protein", CHINESE JOURNAL OF PHARMACOLOGY AND TOXICOLOGY, vol. 25, no. Suppl., 23 September 2011 (2011-09-23), pages 131 - 132, XP009512527, ISSN: 1000-3002
See also references of EP 3431091A4
Attorney, Agent or Firm:
BEIJING JOYSHINE INTELLECTUAL PROPERTY OFFICE (CN)
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