Title:
USE OF TRIPTERYGIUM WILFORDII HOOK.F'S EXTRACTS FOR PREPARATION OF MEDICAMENTS FOR PREVENTING AND TREATING NERVOUS SYSTEM DISORDE RS
Document Type and Number:
WIPO Patent Application WO/2002/017931
Kind Code:
A1
Abstract:
This invention relates to the use of one or more extracts of $i(Tripterygium Wilfordii) Hook.f for the preparation of medicaments for preventing and treating nervous system disorders, said $i(Tripterygium) Hook. f's extracts selected from: Triptolide, tripchloride, tripdiolide, triptriolide, 16-hydroxytriptolide, triptolidemol, triptolidenol, tripterine and wilfortrine. These $i(tripterygium wilfordii') extracts have immunosuppressive activity, as well as have significant nutritional effect of dopaminergic (DA) neuron. It can stimulate the growth of mesenphalic nerve cells, and stimulate elongation of process of primary cultured cortical nerve cells, they can antagonized the injury effect of exogenous toxin, endogenous toxin and excitatory nerve toxin on the nerve cells, and have remarkable protection on cell survival.
Inventors:
WANG XIAOMIN (CN)
HAN JISHENG (CN)
LI FENGQIAO (CN)
WU XIAODONG (CN)
MA DUANDUAN (CN)
JIANG YANWEN (CN)
TIAN RUJIN (CN)
HAN JISHENG (CN)
LI FENGQIAO (CN)
WU XIAODONG (CN)
MA DUANDUAN (CN)
JIANG YANWEN (CN)
TIAN RUJIN (CN)
Application Number:
PCT/CN2000/000258
Publication Date:
March 07, 2002
Filing Date:
September 01, 2000
Export Citation:
Assignee:
WANG XIAOMIN (CN)
HAN JISHENG (CN)
LI FENGQIAO (CN)
WU XIAODONG (CN)
MA DUANDUAN (CN)
JIANG YANWEN (CN)
TIAN RUJIN (CN)
HAN JISHENG (CN)
LI FENGQIAO (CN)
WU XIAODONG (CN)
MA DUANDUAN (CN)
JIANG YANWEN (CN)
TIAN RUJIN (CN)
International Classes:
A61K31/56; A61K31/585; A61K36/37; (IPC1-7): A61K31/585; A61K31/56; A61K35/78
Domestic Patent References:
| WO1996018395A1 | 1996-06-20 |
Foreign References:
| US6004999A | 1999-12-21 | |||
| US5972998A | 1999-10-26 |
Other References:
<< J. Combination Medicin of Chinese and Western>> vol. 9, no. 2, 1989, p 98-99, Li chunguang et al. "Histopathological observation for Tripterygium Wilfordi in treatment of experimental allergic encephalomyelitis"
Attorney, Agent or Firm:
CHINA SCIENCES PATENT & TRADEMARK AGENT LIMITED (Zhongke Building 16th floor No. 80 Haidian
Road Haidian District Beijing 0, CN)
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