Title:
USE OF TRP CHANNEL AGONISTS TO TREAT INFECTIONS
Document Type and Number:
WIPO Patent Application WO/2012/012498
Kind Code:
A3
Abstract:
Methods are described for treating or preventing a respiratory infection by administering an effective amount of a TRP channel agonist.
Inventors:
HAVA DAVID L (US)
CLARKE ROBERT W (US)
CLARKE ROBERT W (US)
Application Number:
PCT/US2011/044628
Publication Date:
June 21, 2012
Filing Date:
July 20, 2011
Export Citation:
Assignee:
PULMATRIX INC (US)
HAVA DAVID L (US)
CLARKE ROBERT W (US)
HAVA DAVID L (US)
CLARKE ROBERT W (US)
International Classes:
A61K45/06; A61K31/23; A61K31/235; A61K31/381; A61K31/496; A61P31/04; A61P31/12
Domestic Patent References:
| WO2006038070A2 | 2006-04-13 | |||
| WO2009130560A1 | 2009-10-29 | |||
| WO2008065666A2 | 2008-06-05 | |||
| WO2009044141A1 | 2009-04-09 | |||
| WO2006029209A2 | 2006-03-16 | |||
| WO2011006073A1 | 2011-01-13 |
Foreign References:
| US20070105086A1 | 2007-05-10 | |||
| EP1709961A1 | 2006-10-11 |
Other References:
NILIUS ET AL: "Transient receptor potential cation channels in disease", PHYSIOLOGICAL REVIEWS,, vol. 87, no. 1, 1 January 2007 (2007-01-01), pages 165 - 217, XP008116003, DOI: 10.1152/PHYSREV.00021.2006
GU QIHAI ET AL: "2-Aminoethoxydiphenyl borate stimulates pulmonary C neurons via the activation of TRPV channels", AMERICAN JOURNAL OF PHYSIOLOGY - LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, vol. 288, no. 5, May 2005 (2005-05-01), pages L932 - L941, XP002660864, ISSN: 1040-0605
LINK TIFFANY M ET AL: "TRPV2 has a pivotal role in macrophage particle binding and phagocytosis.", NATURE IMMUNOLOGY, vol. 11, no. 3, March 2010 (2010-03-01), pages 232 - 239+2PP, XP002672738, ISSN: 1529-2916
LIEDTKE WOLFGANG ET AL: "A possible role for TRPV4 receptors in asthma.", AMERICAN JOURNAL OF PHYSIOLOGY. LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, vol. 287, no. 2, August 2004 (2004-08-01), pages L269 - L271, XP002672739, ISSN: 1040-0605
LORENZO IVAN M ET AL: "TRPV4 channel participates in receptor-operated calcium entry and ciliary beat frequency regulation in mouse airway epithelial cells", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 105, no. 34, August 2008 (2008-08-01), pages 12611 - 12616, XP002672740, ISSN: 0027-8424
YANIRÉ N ANDRADE ET AL: "TRPV4 Channel is Involved in the Coupling of Fluid Viscosity Changes to Epithelial Ciliary Activity", THE JOURNAL OF CELL BIOLOGY, vol. 168, no. 6, 14 March 2005 (2005-03-14), ROCKEFELLER UNIVERSITY PRESS, US, pages 869 - 874, XP008130546, ISSN: 0021-9525, DOI: 10.1083/JCB.200408070
EVERAERTS W ET AL: "The vanilloid transient receptor potential channel TRPV4: From structure to disease", PROGRESS IN BIOPHYSICS AND MOLECULAR BIOLOGY, vol. 103, no. 1, 14 October 2010 (2010-10-14), PERGAMON PRESS, OXFORD, GB, pages 2 - 17, XP027181425, ISSN: 0079-6107, [retrieved on 20091014]
VINCENT FABIEN ET AL: "Identification and characterization of novel TRPV4 modulators.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 389, no. 3, 20 November 2009 (2009-11-20), pages 490 - 494, XP002672741, ISSN: 1090-2104
GU QIHAI ET AL: "2-Aminoethoxydiphenyl borate stimulates pulmonary C neurons via the activation of TRPV channels", AMERICAN JOURNAL OF PHYSIOLOGY - LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, vol. 288, no. 5, May 2005 (2005-05-01), pages L932 - L941, XP002660864, ISSN: 1040-0605
LINK TIFFANY M ET AL: "TRPV2 has a pivotal role in macrophage particle binding and phagocytosis.", NATURE IMMUNOLOGY, vol. 11, no. 3, March 2010 (2010-03-01), pages 232 - 239+2PP, XP002672738, ISSN: 1529-2916
LIEDTKE WOLFGANG ET AL: "A possible role for TRPV4 receptors in asthma.", AMERICAN JOURNAL OF PHYSIOLOGY. LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, vol. 287, no. 2, August 2004 (2004-08-01), pages L269 - L271, XP002672739, ISSN: 1040-0605
LORENZO IVAN M ET AL: "TRPV4 channel participates in receptor-operated calcium entry and ciliary beat frequency regulation in mouse airway epithelial cells", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 105, no. 34, August 2008 (2008-08-01), pages 12611 - 12616, XP002672740, ISSN: 0027-8424
YANIRÉ N ANDRADE ET AL: "TRPV4 Channel is Involved in the Coupling of Fluid Viscosity Changes to Epithelial Ciliary Activity", THE JOURNAL OF CELL BIOLOGY, vol. 168, no. 6, 14 March 2005 (2005-03-14), ROCKEFELLER UNIVERSITY PRESS, US, pages 869 - 874, XP008130546, ISSN: 0021-9525, DOI: 10.1083/JCB.200408070
EVERAERTS W ET AL: "The vanilloid transient receptor potential channel TRPV4: From structure to disease", PROGRESS IN BIOPHYSICS AND MOLECULAR BIOLOGY, vol. 103, no. 1, 14 October 2010 (2010-10-14), PERGAMON PRESS, OXFORD, GB, pages 2 - 17, XP027181425, ISSN: 0079-6107, [retrieved on 20091014]
VINCENT FABIEN ET AL: "Identification and characterization of novel TRPV4 modulators.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 389, no. 3, 20 November 2009 (2009-11-20), pages 490 - 494, XP002672741, ISSN: 1090-2104
Attorney, Agent or Firm:
UNDERWOOD, Robert H. et al. (28 State StreetBoston, Massachusetts, US)
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