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Title:
USE OF TRPC6 MRNA LEVELS IN PERIPHERAL BLOOD CELLS FOR EARLY DETECTION/DIAGNOSIS OF SENILE DEMENTIA
Document Type and Number:
WIPO Patent Application WO/2014/117680
Kind Code:
A3
Abstract:
The invention discloses the use of TRPC6 mRNA levels in peripheral blood cells for the early detection/diagnosis of senile dementia. Furthermore, the present invention sets forth the use of a classic transient receptor potential channel 6 (TRPC6) gene or protein thereof in preparing a reagent or test kit for detecting or diagnosing Alzheimer's disease. The present invention further discloses a polypeptide used to prepare a medicament that treats AD, and relates to a composition of said polypeptide.

Inventors:
WANG YIZHENG (CN)
WANG JUNFENG (CN)
LU RUI (CN)
Application Number:
PCT/CN2014/071325
Publication Date:
September 25, 2014
Filing Date:
January 24, 2014
Export Citation:
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Assignee:
SHANGHAI INST BIOL SCIENCES (CN)
International Classes:
A61K38/17; A61P25/28; C07K14/47; C12Q1/68
Domestic Patent References:
WO2005119262A22005-12-15
WO2005074923A12005-08-18
Foreign References:
CN101948912A2011-01-19
CN102100913A2011-06-22
CN1714101A2005-12-28
US20060257500A12006-11-16
EP1527343A22005-05-04
Other References:
CUI, LONGBIAO ET AL.: "The TRPC6 Ion Channel in Central Nervous System", CHINESE JOURNAL OF NEUROANATOMY, vol. 27, no. 5, 31 December 2011 (2011-12-31), pages 565 - 570
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (Building No.1 Universal High-Tech Plaza,958 Zhen Bei Road, Putuo District, Shanghai 3, CN)
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