Title:
USE OF TUMOR-INFILTRATING LYMPHOCYTE IN TREATMENT OF DISEASES
Document Type and Number:
WIPO Patent Application WO/2023/138598
Kind Code:
A1
Abstract:
Use of a tumor-infiltrating lymphocyte in the treatment of diseases, in particular, use of a tumor-infiltrating lymphocyte (TIL) in the preparation of a drug. The drug is used for preventing and/or treating tumors. The TIL is obtained by means of the following culture method: performing at least one stage of in-vitro amplification on a TIL derived from tumor tissue, wherein in a single stage of in-vitro amplification, the in-vitro-amplifed and/or non-in-vitro-amplifed TIL is co-cultured with feeder cells after same comes in contact with a T-cell activator and/or a T-cell growth factor for a certain period of time.
Inventors:
LIU YARONG (CN)
ZHONG MENGYANG (CN)
ZHONG MENGYANG (CN)
Application Number:
PCT/CN2023/072784
Publication Date:
July 27, 2023
Filing Date:
January 18, 2023
Export Citation:
Assignee:
SUZHOU GRIT BIOTECHNOLOGY CO LTD (CN)
SHANGHAI GRIT BIOTECHNOLOGY CO LTD (CN)
ZHUHAI TUOYU BIOTECHNOLOGY CO LTD (CN)
ZHUHAI GRIT BIOTECHNOLOGY CO LTD (CN)
SHANGHAI GRIT BIOTECHNOLOGY CO LTD (CN)
ZHUHAI TUOYU BIOTECHNOLOGY CO LTD (CN)
ZHUHAI GRIT BIOTECHNOLOGY CO LTD (CN)
International Classes:
C12N5/0783; A61K35/17; A61P35/00
Domestic Patent References:
| WO2022166947A1 | 2022-08-11 | |||
| WO2022105816A1 | 2022-05-27 | |||
| WO2022135525A1 | 2022-06-30 | |||
| WO2019136459A1 | 2019-07-11 | |||
| WO2021108455A1 | 2021-06-03 |
Foreign References:
| CN111601883A | 2020-08-28 | |||
| CN106574244A | 2017-04-19 | |||
| CN113272421A | 2021-08-17 | |||
| US20190008899A1 | 2019-01-10 | |||
| US20200164090A1 | 2020-05-28 |
Other References:
FORGET MARIE-ANDRÉE, TAVERA RENÉ J., HAYMAKER CARA, RAMACHANDRAN RENJITH, MALU SHUTI, ZHANG MINYING, WARDELL SETH, FULBRIGHT ORENT: "A Novel Method to Generate and Expand Clinical-Grade, Genetically Modified, Tumor-Infiltrating Lymphocytes", FRONTIERS IN IMMUNOLOGY, vol. 8, XP093079144, DOI: 10.3389/fimmu.2017.00908
Attorney, Agent or Firm:
CHINA SINDA INTELLECTUAL PROPERTY LIMITED (CN)
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