Title:
USE OF VAGINAL MICROFLORA AS OVARIAN CANCER BIOMARKER
Document Type and Number:
WIPO Patent Application WO/2020/096024
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing an early diagnosis method for ovarian cancer. More specifically, the present invention pertains to a method for diagnosing ovarian cancer possibility in a premenopausal subject, wherein, when the composition of the vaginal microflora of the subject is highly similar to the composition of the vaginal microflora of an ovarian cancer patient, then the subject is diagnosed as having ovarian cancer at a high possibility.
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Inventors:
SUTANI TAKASHI (JP)
SHIRAHIGE KATSUHIKO (JP)
OKAMOTO AIKOU (JP)
MORIKAWA ASUKA (JP)
SHIRAHIGE KATSUHIKO (JP)
OKAMOTO AIKOU (JP)
MORIKAWA ASUKA (JP)
Application Number:
PCT/JP2019/043785
Publication Date:
May 14, 2020
Filing Date:
November 08, 2019
Export Citation:
Assignee:
UNIV TOKYO (JP)
THE JIKEI UNIV SCHOOL OF MEDICINE (JP)
THE JIKEI UNIV SCHOOL OF MEDICINE (JP)
International Classes:
C12Q1/04; C12Q1/686; C12N15/09
Domestic Patent References:
| WO2017180909A1 | 2017-10-19 |
Foreign References:
| KR20180098154A | 2018-09-03 |
Other References:
BANERJEE S. ET AL.: "The ovarian cancer oncobiome", ONCOTARGET, vol. 8, no. 22, 2017, pages 36225 - 36245, XP055705477, DOI: 10.18632/oncotarget.16717
MERT I. ET AL.: "Case for a role of the microbiome in gynecologic cancers: Clinician' s perspective", J . OBSTET. GYNAECOL. RES ., vol. 44, no. 9, 2 August 2018 (2018-08-02), pages 1693 - 1704, XP055705518, DOI: 10.1111/jog.13701
MUHLEISEN AL. ET AL.: "Menopause and the vaginal microbiome", MATURITAS, vol. 91, 2016, pages 42 - 50, XP029649867, DOI: 10.1016/j.maturitas.2016.05.015
SUTANI, TAKASHI ET. AL.: "Vaginal microbiome features associated with ovarian cancer patients", THE 41ST ANNUAL MEETING OF THE MOLECULAR BIOLOGY SOCIETY OF JAPAN, 29 November 2018 (2018-11-29)
MERT I. ET AL.: "Case for a role of the microbiome in gynecologic cancers: Clinician' s perspective", J . OBSTET. GYNAECOL. RES ., vol. 44, no. 9, 2 August 2018 (2018-08-02), pages 1693 - 1704, XP055705518, DOI: 10.1111/jog.13701
MUHLEISEN AL. ET AL.: "Menopause and the vaginal microbiome", MATURITAS, vol. 91, 2016, pages 42 - 50, XP029649867, DOI: 10.1016/j.maturitas.2016.05.015
SUTANI, TAKASHI ET. AL.: "Vaginal microbiome features associated with ovarian cancer patients", THE 41ST ANNUAL MEETING OF THE MOLECULAR BIOLOGY SOCIETY OF JAPAN, 29 November 2018 (2018-11-29)
Attorney, Agent or Firm:
OKUHARA Koji et al. (JP)
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