Title:
USES OF ASCL1 IN INDUCING ASTROCYTE TRANSDIFFERENTATION INTO FUNCTIONAL NEURONS
Document Type and Number:
WIPO Patent Application WO/2016/058537
Kind Code:
A1
Abstract:
Uses of an achaete-scute complex homolog-like 1 (Ascl1) gene or a protein thereof or an accelerator thereof: (i) use in preparing a pharmaceutical composition for inducing astrocytes to become functional neuron cells; and/or (ii) use in preparing a pharmaceutical composition for treating neurological disorders such as neurodegenerative pathologies, central nervous system trauma, and so on.
Inventors:
CHENG LEPING (CN)
ZHANG XIAOHUI (CN)
LIU YUEGUANG (CN)
MIAO QINGLONG (CN)
YUAN JIACHENG (CN)
ZHANG XIAOHUI (CN)
LIU YUEGUANG (CN)
MIAO QINGLONG (CN)
YUAN JIACHENG (CN)
Application Number:
PCT/CN2015/091944
Publication Date:
April 21, 2016
Filing Date:
October 14, 2015
Export Citation:
Assignee:
SHANGHAI INST BIOL SCIENCES (CN)
International Classes:
A61K48/00; A61K38/17; A61K45/00; A61P25/00; C12N5/10; C12N15/63; C12Q1/02; C12Q1/68
Domestic Patent References:
| WO2013025963A2 | 2013-02-21 | |||
| WO2011091048A1 | 2011-07-28 |
Foreign References:
| CN102796696A | 2012-11-28 | |||
| CN103773771A | 2014-05-07 |
Other References:
DING, DAOFANG ET AL.: "Mash1 efficiently reprograms rat astrocytes into neurons", NEURAL REGENERATION RESEARCH, vol. 9, 31 January 2014 (2014-01-31), pages 25 - 32, ISSN: 1876-7958
PATTYN, A. ET AL.: "Ascl1/Mash1 is required for the development of central serotonergic neruons", NATURE NEUROSCIENCE, vol. 7, no. 6, 9 May 2004 (2004-05-09), pages 589 - 595
ZHANG, ZHIYUAN ET AL.: "The role of Mash 1 in the neuronal differentiation of the neural stem cells in SVZa", CHINESE JOURNAL OF NEUROMEDICINE, vol. 5, no. 5, 30 May 2006 (2006-05-30), pages 471 - 474, ISSN: 1671-8925
PATTYN, A. ET AL.: "Delays in neuronal differentiation in Mash1/Ascl1 mutants", DEVELOPMENTAL BIOLOGY, vol. 295, 4 May 2006 (2006-05-04), pages 67 - 75, ISSN: 1095-564X
PATTYN, A. ET AL.: "Ascl1/Mash1 is required for the development of central serotonergic neruons", NATURE NEUROSCIENCE, vol. 7, no. 6, 9 May 2004 (2004-05-09), pages 589 - 595
ZHANG, ZHIYUAN ET AL.: "The role of Mash 1 in the neuronal differentiation of the neural stem cells in SVZa", CHINESE JOURNAL OF NEUROMEDICINE, vol. 5, no. 5, 30 May 2006 (2006-05-30), pages 471 - 474, ISSN: 1671-8925
PATTYN, A. ET AL.: "Delays in neuronal differentiation in Mash1/Ascl1 mutants", DEVELOPMENTAL BIOLOGY, vol. 295, 4 May 2006 (2006-05-04), pages 67 - 75, ISSN: 1095-564X
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
上海一平知识产权代理有限公司 (CN)
上海一平知识产权代理有限公司 (CN)
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