Title:
USES OF CYCLIC PEPTIDES FOR TREATING AND PREVENTING ATHEROSCLEROSIS
Document Type and Number:
WIPO Patent Application WO/2014/165563
Kind Code:
A3
Abstract:
The present invention provides cyclic compounds that are useful in preventing or treating atherosclerosis or related disorders. The invention also provides therapeutic methods for treating or preventing various diseases or disorders associated with or mediated by atherosclerosis. Further provided in the invention are methods of screening for anti-atherosclerotic cyclic peptides with improved properties.
Inventors:
GHADIRI M REZA (US)
LEMAN LUKE J (US)
ZHAO YANNAN (US)
MARYANOFF BRUCE E (US)
LEMAN LUKE J (US)
ZHAO YANNAN (US)
MARYANOFF BRUCE E (US)
Application Number:
PCT/US2014/032620
Publication Date:
January 22, 2015
Filing Date:
April 02, 2014
Export Citation:
Assignee:
SCRIPPS RESEARCH INST (US)
GHADIRI M REZA (US)
LEMAN LUKE J (US)
ZHAO YANNAN (US)
MARYANOFF BRUCE E (US)
GHADIRI M REZA (US)
LEMAN LUKE J (US)
ZHAO YANNAN (US)
MARYANOFF BRUCE E (US)
International Classes:
A61K38/12; A61K38/00; A61K38/08; A61P3/04; A61P25/00; A61P25/28
Foreign References:
| US20130005644A1 | 2013-01-03 |
Other References:
DE VRIES ET AL.: "Complement factor C5a as mast cell activator mediates vascular remodelling in vein graft disease.", CARDIOVASC RES., vol. 97, no. 2, 2012, pages 311 - 20, XP055292097
MONTERO ET AL.: "Self-Assembling Peptide Nanotubes with Antiviral Activity against Hepatitis C Virus.", CHEM BIOL., vol. 18, no. 11, 2011, pages 1453 - 1462, XP055292098
See also references of EP 2981277A4
MONTERO ET AL.: "Self-Assembling Peptide Nanotubes with Antiviral Activity against Hepatitis C Virus.", CHEM BIOL., vol. 18, no. 11, 2011, pages 1453 - 1462, XP055292098
See also references of EP 2981277A4
Attorney, Agent or Firm:
FITTING, Thomas et al. (10550 North Torrey Pines Road TPC-, La Jolla CA, US)
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