Title:
USES OF DKK-1 PROTEIN IN DIAGNOSIS OF CANCERS
Document Type and Number:
WIPO Patent Application WO/2007/104181
Kind Code:
A1
Abstract:
DKK-1 protein or nucleic acid sequence can be used in the manufacturing of reagents
or kits for diagnosis of cancers which are selected from the group of liver cancer,
lung cancer, breast cancer and glioma. Specific antibodies against DKK-1 protein
or specific nucleic acid probes capable of hybridizing to DKK-1 which act as reagents
for diagnosis of cancers, are made react with cell samples. The binding amount
of the antibodies or probes can be obtained by dint of detecting the detectable
labels which couple the antibodies or probes. Then the binding amount can be compared
with a standard from normal cells.
Inventors:
QIN, Wenxin (No.25, 2200 Xie-Tu Road, 2 Shanghai, Shanghai, CN)
覃文新 (中国上海市斜土路2200弄25号, Shanghai 2, Shanghai, CN)
ZHANG, Haitao (No.25, 2200 Xie-Tu Road, 2 Shanghai, Shanghai, CN)
张海涛 (中国上海市斜土路2200弄25号, Shanghai 2, Shanghai, CN)
YU, Yanjun (No.25, 2200 Xie-Tu Road, 2 Shanghai, Shanghai, CN)
余艳军 (中国上海市斜土路2200弄25号, Shanghai 2, Shanghai, CN)
YOU, Haiyan (No.25, 2200 Xie-Tu Road, 2 Shanghai, Shanghai, CN)
游海燕 (中国上海市斜土路2200弄25号, Shanghai 2, Shanghai, CN)
YANG, Shengli (25/Ln 2200 Xie-Tu Road, 2 Shanghai, Shanghai, CN)
覃文新 (中国上海市斜土路2200弄25号, Shanghai 2, Shanghai, CN)
ZHANG, Haitao (No.25, 2200 Xie-Tu Road, 2 Shanghai, Shanghai, CN)
张海涛 (中国上海市斜土路2200弄25号, Shanghai 2, Shanghai, CN)
YU, Yanjun (No.25, 2200 Xie-Tu Road, 2 Shanghai, Shanghai, CN)
余艳军 (中国上海市斜土路2200弄25号, Shanghai 2, Shanghai, CN)
YOU, Haiyan (No.25, 2200 Xie-Tu Road, 2 Shanghai, Shanghai, CN)
游海燕 (中国上海市斜土路2200弄25号, Shanghai 2, Shanghai, CN)
YANG, Shengli (25/Ln 2200 Xie-Tu Road, 2 Shanghai, Shanghai, CN)
Application Number:
CN2006/000382
Publication Date:
September 20, 2007
Filing Date:
March 13, 2006
Export Citation:
Assignee:
SHANGHAI CANCER INSTITUTE (QIN Wenxin, No. 25 2200 Xie-Tu Road, 2 Shanghai, Shanghai, CN)
上海市肿瘤研究所 (中国上海市斜土路2200弄25号, Shanghai 2, Shanghai, CN)
QIN, Wenxin (No.25, 2200 Xie-Tu Road, 2 Shanghai, Shanghai, CN)
覃文新 (中国上海市斜土路2200弄25号, Shanghai 2, Shanghai, CN)
ZHANG, Haitao (No.25, 2200 Xie-Tu Road, 2 Shanghai, Shanghai, CN)
张海涛 (中国上海市斜土路2200弄25号, Shanghai 2, Shanghai, CN)
YU, Yanjun (No.25, 2200 Xie-Tu Road, 2 Shanghai, Shanghai, CN)
余艳军 (中国上海市斜土路2200弄25号, Shanghai 2, Shanghai, CN)
YOU, Haiyan (No.25, 2200 Xie-Tu Road, 2 Shanghai, Shanghai, CN)
游海燕 (中国上海市斜土路2200弄25号, Shanghai 2, Shanghai, CN)
上海市肿瘤研究所 (中国上海市斜土路2200弄25号, Shanghai 2, Shanghai, CN)
QIN, Wenxin (No.25, 2200 Xie-Tu Road, 2 Shanghai, Shanghai, CN)
覃文新 (中国上海市斜土路2200弄25号, Shanghai 2, Shanghai, CN)
ZHANG, Haitao (No.25, 2200 Xie-Tu Road, 2 Shanghai, Shanghai, CN)
张海涛 (中国上海市斜土路2200弄25号, Shanghai 2, Shanghai, CN)
YU, Yanjun (No.25, 2200 Xie-Tu Road, 2 Shanghai, Shanghai, CN)
余艳军 (中国上海市斜土路2200弄25号, Shanghai 2, Shanghai, CN)
YOU, Haiyan (No.25, 2200 Xie-Tu Road, 2 Shanghai, Shanghai, CN)
游海燕 (中国上海市斜土路2200弄25号, Shanghai 2, Shanghai, CN)
International Classes:
C12Q1/68; C07K14/47; C12N15/12; G01N33/15; G01N33/50; G01N33/53; G01N33/574; C12Q1/68; C07K14/435; C12N15/12; G01N33/15; G01N33/50; G01N33/53; G01N33/574
Attorney, Agent or Firm:
SHANGHAI PATENT & TRADEMARK LAW OFFICE, LLC. (TAO Jiarong, 435 Guiping Road, 3 Shanghai, Shanghai, CN)