Title:
USES OF PDCD5 POLYPEPTIDE FOR TUMOR CHEMOTHERAPY AND ORGAN PROTECTION
Document Type and Number:
WIPO Patent Application WO/2009/092323
Kind Code:
A1
Abstract:
Provided are uses of PDCD5 polypeptide or polynucleotide encoding it for preparing
tumor chemo-sensitizer and protecting normal or diseased tissues and organs
from injury or further damage. Drug combinations comprising chemotherapeutic
drugs and effective amount of PDCD5 polypeptide or polynucleotide encoding
it for sensitization are also provided.
Inventors:
WANG YING (CN)
MA DALONG (CN)
SONG QUANSHENG (CN)
ZHANG YINGMEI (CN)
LOU YAXIN (CN)
KE XIAOYAN (CN)
SHI LIN (CN)
WANG YANFANG (CN)
MA DALONG (CN)
SONG QUANSHENG (CN)
ZHANG YINGMEI (CN)
LOU YAXIN (CN)
KE XIAOYAN (CN)
SHI LIN (CN)
WANG YANFANG (CN)
Application Number:
PCT/CN2009/070174
Publication Date:
July 30, 2009
Filing Date:
January 16, 2009
Export Citation:
Assignee:
UNIV BEIJING (CN)
WANG YING (CN)
MA DALONG (CN)
SONG QUANSHENG (CN)
ZHANG YINGMEI (CN)
LOU YAXIN (CN)
KE XIAOYAN (CN)
SHI LIN (CN)
WANG YANFANG (CN)
WANG YING (CN)
MA DALONG (CN)
SONG QUANSHENG (CN)
ZHANG YINGMEI (CN)
LOU YAXIN (CN)
KE XIAOYAN (CN)
SHI LIN (CN)
WANG YANFANG (CN)
International Classes:
A61K38/17; A61K48/00; A61P35/00; A61P39/00
Foreign References:
| CN1869242A | 2006-11-29 | |||
| CN1218833A | 1999-06-09 | |||
| CN101214371A | 2008-07-09 | |||
| CN1218833A | 1999-06-09 |
Other References:
LI, H.P. ET AL.: "Effect of rhTFAR19 protein on cell apoptosis of 7721 liver cancer cells induced by hydroxy camptothecin.", JOURNAL OF BEIJING MEDICAL UNIVERSITY, vol. 32, no. 5, October 2000 (2000-10-01), pages 408 - 410
GU, L. ET AL.: "Effects ofTFAR19 gene on the in vivo biorheological properties and pathogenicity of mouse erythroleukemia cell line MEL.", SCIENCE IN CHINA SERIES C: LIFE SCIENCES, vol. 50, no. 1, February 2007 (2007-02-01), pages 111 - 119, XP019485671
YU, J. ET AL.: "Cooperation of protein TFAR19 and mifepristone on apoptosis of human prostate cancer cells PC-3M.", CHINESE PHARMACOLOGICAL BULLETIN, vol. 24, no. 7, July 2008 (2008-07-01), pages 919 - 923, XP008137709
ZHANG, D. ET AL.: "RhPDCD5 protein can enhance the apoptosis of SiHa ceivical cells induced by IFN Y .", CHIN. J. CLIN. OBSTET. GYNECOL., vol. 5, no. 4, July 2004 (2004-07-01), pages 286 - 289, XP008139322
WANG, Y. ET AL.: "Cellular uptake of exogenous human PDCD5 protein.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 281, no. 34, August 2006 (2006-08-01), pages 24803 - 24817, XP008137706
LIU ET AL., BIOCHEM. BIOPHYS. RES. COMMUN., vol. 254, 1999, pages 203 - 210
CHEN ET AL., FEBS LETT., vol. 509, 2001, pages 191 - 196
RUI ET AL., LIFE SCI., vol. 71, 2002, pages 1771 - 1778
GREEN; LOEWENSTEIN, CELL, vol. 55, 1988, pages 1179 - 1188
DEROSSI ET AL., J. BIOL. CHEM., vol. 269, 1994, pages 10444 - 10450
WANG ET AL., J. BIOL. CHEM., vol. 281, 2006, pages 24803 - 24817
LI ET AL., J. BEIJING MED. UNIV., vol. 32, no. 5, 2000, pages 408 - 410
ZHANG ET AL., CHIN. J.CLIN. OBSTET. GYNECOL., vol. 5, no. 4, 2004, pages 286 - 289
SMITH; WATERMAN, ADV. APPL. MATH., vol. 2, 1981, pages 482
NEEDLEMAN; WUNSCH, J. MOL. BIOL., vol. 48, 1970, pages 443
PEARSON; LIPMAN, PROC. NATL. ACAD. SCI., USA, vol. 85, 1988, pages 2444
MASSEYEFF R.F. ET AL., METHODS IMMUNOLOGY ANALYSIS, vol. 3, 1993, pages 237 - 238
YING WANG ET AL., JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 281, no. 34, 2006, pages 24803 - 24817
GU, L. ET AL.: "Effects ofTFAR19 gene on the in vivo biorheological properties and pathogenicity of mouse erythroleukemia cell line MEL.", SCIENCE IN CHINA SERIES C: LIFE SCIENCES, vol. 50, no. 1, February 2007 (2007-02-01), pages 111 - 119, XP019485671
YU, J. ET AL.: "Cooperation of protein TFAR19 and mifepristone on apoptosis of human prostate cancer cells PC-3M.", CHINESE PHARMACOLOGICAL BULLETIN, vol. 24, no. 7, July 2008 (2008-07-01), pages 919 - 923, XP008137709
ZHANG, D. ET AL.: "RhPDCD5 protein can enhance the apoptosis of SiHa ceivical cells induced by IFN Y .", CHIN. J. CLIN. OBSTET. GYNECOL., vol. 5, no. 4, July 2004 (2004-07-01), pages 286 - 289, XP008139322
WANG, Y. ET AL.: "Cellular uptake of exogenous human PDCD5 protein.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 281, no. 34, August 2006 (2006-08-01), pages 24803 - 24817, XP008137706
LIU ET AL., BIOCHEM. BIOPHYS. RES. COMMUN., vol. 254, 1999, pages 203 - 210
CHEN ET AL., FEBS LETT., vol. 509, 2001, pages 191 - 196
RUI ET AL., LIFE SCI., vol. 71, 2002, pages 1771 - 1778
GREEN; LOEWENSTEIN, CELL, vol. 55, 1988, pages 1179 - 1188
DEROSSI ET AL., J. BIOL. CHEM., vol. 269, 1994, pages 10444 - 10450
WANG ET AL., J. BIOL. CHEM., vol. 281, 2006, pages 24803 - 24817
LI ET AL., J. BEIJING MED. UNIV., vol. 32, no. 5, 2000, pages 408 - 410
ZHANG ET AL., CHIN. J.CLIN. OBSTET. GYNECOL., vol. 5, no. 4, 2004, pages 286 - 289
SMITH; WATERMAN, ADV. APPL. MATH., vol. 2, 1981, pages 482
NEEDLEMAN; WUNSCH, J. MOL. BIOL., vol. 48, 1970, pages 443
PEARSON; LIPMAN, PROC. NATL. ACAD. SCI., USA, vol. 85, 1988, pages 2444
MASSEYEFF R.F. ET AL., METHODS IMMUNOLOGY ANALYSIS, vol. 3, 1993, pages 237 - 238
YING WANG ET AL., JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 281, no. 34, 2006, pages 24803 - 24817
Attorney, Agent or Firm:
UNITALEN ATTORNEYS AT LAW (Scitech PlaceNo.22, Jian Guo Men Wai Ave., Chao Yang District, Beijing 4, CN)
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