Title:
USES OF TRITERPENOID MIXTURE FOR TREATING MULTIPLE SCLEROSIS
Document Type and Number:
WIPO Patent Application WO/2018/082034
Kind Code:
A1
Abstract:
Disclosed herein is a novel use of a triterpenoid mixture for the treatment of multiple sclerosis (MS). The triterpenoid mixture consists of, ganoderic acid A (GAA), ganoderic acid B (GAB), ganoderic acid C (GAC), ganoderic acid C5 (GAC5), ganoderic acid C6 (GAC6), ganoderic acid D (GAD), ganoderic acid E (GAE), ganoderic acid G (GAG), and ganoderenic acid D. The triterpenoid mixture may be administered to a subject suffering from MS in a dose of about 1 to 10 mg/Kg to ameliorate or alleviate symptoms associated with MS.
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Inventors:
CHEN TENG-HAI (CN)
HUNAG CHENG-PO (CN)
CHEN KUANG-DEE (CN)
CHEN MON-TARNG (CN)
CHAO I-SHUAN (CN)
WANG CHIEN-YUAN (CN)
HUANG SHIN HUEI (CN)
TSAO CHENG CHIU (CN)
HUNAG CHENG-PO (CN)
CHEN KUANG-DEE (CN)
CHEN MON-TARNG (CN)
CHAO I-SHUAN (CN)
WANG CHIEN-YUAN (CN)
HUANG SHIN HUEI (CN)
TSAO CHENG CHIU (CN)
Application Number:
PCT/CN2016/104681
Publication Date:
May 11, 2018
Filing Date:
November 04, 2016
Export Citation:
Assignee:
TRINEO BIOTECHNOLOGY CO LTD (CN)
International Classes:
A61K31/575; A61K31/569; A61P25/00; A61P25/28
Foreign References:
| CN106074566A | 2016-11-09 | |||
| US7390512B2 | 2008-06-24 | |||
| EP2260851A1 | 2010-12-15 | |||
| CN1520300A | 2004-08-11 | |||
| CN102574890A | 2012-07-11 | |||
| US20130303607A1 | 2013-11-14 |
Other References:
PAREEK, T.K. ET AL.: "Triterpenoid modulation of IL-17 and Nrf-2 expression ameliorates neuroinflammation and promotes remyelination in autoimmune encephalomyelitis", SCIENTIFIC REPORTS, vol. 1, no. 201, 19 December 2011 (2011-12-19), pages 1 - 11, XP055501651
DUDHGAONKAR, S. ET AL.: "Suppression of the inflammatory response by triterpenes isolated from the mushroom Ganoderma lucidum", INTERNATIONAL IMMUNOPHARMACOLOGY, vol. 9, no. 11, 31 December 2009 (2009-12-31), pages 1272 - 1280, XP026614221
See also references of EP 3509602A4
DUDHGAONKAR, S. ET AL.: "Suppression of the inflammatory response by triterpenes isolated from the mushroom Ganoderma lucidum", INTERNATIONAL IMMUNOPHARMACOLOGY, vol. 9, no. 11, 31 December 2009 (2009-12-31), pages 1272 - 1280, XP026614221
See also references of EP 3509602A4
Attorney, Agent or Firm:
CHINA ZHENGHE INTELLECTUAL PROPERTY AGENCY (CN)
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