Title:
USING HEAT SHOCK PROTEINS TO IMPROVE THE THERAPEUTIC BENEFIT OF A NON-VACCINE TREATMENT MODALITY
Document Type and Number:
WIPO Patent Application WO2003090686
Kind Code:
A3
Abstract:
The present invention relates to methods of improving a treatment outcome comprising administering a heat shock protein (HSP) preparation or an a-2-macro globulin (a2M) preparation with a non-vaccine treatment modality. In particular, an HSP preparation or an a2M preparation is administered in conjunction with a non-vaccine treatment modality for the treatment of cancer or infectious diseases. In the practice of the invention, a preparation comprising HSPs such as but not limited to, hsp70, hsp90 and gp96 alone or in combination with each other, noncovalently or covalently bound to antigenic molecules or a2M, noncovalently or covalently bound to antigenic molecules is administered in conjunction with a non-vaccine treatment modality.
Inventors:
SRIVASTAVA PRAMOD K (US)
Application Number:
PCT/US2003/012802
Publication Date:
March 02, 2006
Filing Date:
April 25, 2003
Export Citation:
Assignee:
UNIV CONNECTICUT HEALTH CT (US)
SRIVASTAVA PRAMOD K (US)
SRIVASTAVA PRAMOD K (US)
International Classes:
A61K38/55; A61K31/496; A61K31/7048; A61K38/02; A61K45/06; A61P35/00; A61P35/02; (IPC1-7): A61K39/00; A61K39/385
Other References:
DRUKER B.J. ET AL: "Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome", NEW ENGLAND JOURNAL OF MEDICINE, vol. 344, no. 14, 5 April 2001 (2001-04-05), pages 1038 - 1042, XP009053343
TODRYK S. ET AL: "Heat shock protein 70 induced during tumor cell killing induces Th1 cytokines and targets immature dendritic cell precursors to enhance antigen uptake", JOURNAL OF IMMUNOLOGY, vol. 163, no. 3, 1 August 1999 (1999-08-01), pages 1398 - 1408, XP002195363
BRELOER M. ET AL: "In vivo and in vitro activation of cells after administration of Agnegative heat shock proteins", JOURNAL OF IMMUNOLOGY, vol. 162, no. 6, 15 March 1999 (1999-03-15), pages 3141 - 3147, XP002143655
MOLLDREM J.J. ET AL: "Evidence that specific T lymphocytes may participate in the elimination of chronic myelogenous leukemia", NATURE MEDICINE, vol. 6, no. 9, September 2000 (2000-09-01), pages 1018 - 1023, XP002993663
GALLUCCI S., LOLKEMA M. AND MATZINGER P.: "Natural adjuvants: endogenous activators of dendritic cells", NATURE MEDICINE, vol. 5, no. 11, November 1999 (1999-11-01), pages 1249 - 1255, XP002908497
TAMURA Y. ET AL: "Immunotherapy of tumors with autologous tumor-derived heat shock protein preparations", SCIENCE, vol. 278, no. 5335, 3 October 1997 (1997-10-03), pages 117 - 120, XP002118457
DATABASE MEDLINE [online] HOOVER S. ET AL: "Cyclophosphamide and abrogation of tumor-induced suppressor T cell activity", XP002993664, accession no. STN Database accession no. (NLM 2138931)
BANCHEREAU J. AND STEINMAN R.M.: "Dendritic cells and the control of immunity", NATURE, vol. 392, no. 6673, 19 March 1998 (1998-03-19), pages 245 - 252, XP002134557
NISHIMURA T. ET AL: "The critical role of Th1-dominant immunity in tumor immunology", CANCER CHEMOTHER. PHARMACOL., vol. 46, July 2000 (2000-07-01), pages S52 - S61, XP002993665
TODRYK S. ET AL: "Heat shock protein 70 induced during tumor cell killing induces Th1 cytokines and targets immature dendritic cell precursors to enhance antigen uptake", JOURNAL OF IMMUNOLOGY, vol. 163, no. 3, 1 August 1999 (1999-08-01), pages 1398 - 1408, XP002195363
BRELOER M. ET AL: "In vivo and in vitro activation of cells after administration of Agnegative heat shock proteins", JOURNAL OF IMMUNOLOGY, vol. 162, no. 6, 15 March 1999 (1999-03-15), pages 3141 - 3147, XP002143655
MOLLDREM J.J. ET AL: "Evidence that specific T lymphocytes may participate in the elimination of chronic myelogenous leukemia", NATURE MEDICINE, vol. 6, no. 9, September 2000 (2000-09-01), pages 1018 - 1023, XP002993663
GALLUCCI S., LOLKEMA M. AND MATZINGER P.: "Natural adjuvants: endogenous activators of dendritic cells", NATURE MEDICINE, vol. 5, no. 11, November 1999 (1999-11-01), pages 1249 - 1255, XP002908497
TAMURA Y. ET AL: "Immunotherapy of tumors with autologous tumor-derived heat shock protein preparations", SCIENCE, vol. 278, no. 5335, 3 October 1997 (1997-10-03), pages 117 - 120, XP002118457
DATABASE MEDLINE [online] HOOVER S. ET AL: "Cyclophosphamide and abrogation of tumor-induced suppressor T cell activity", XP002993664, accession no. STN Database accession no. (NLM 2138931)
BANCHEREAU J. AND STEINMAN R.M.: "Dendritic cells and the control of immunity", NATURE, vol. 392, no. 6673, 19 March 1998 (1998-03-19), pages 245 - 252, XP002134557
NISHIMURA T. ET AL: "The critical role of Th1-dominant immunity in tumor immunology", CANCER CHEMOTHER. PHARMACOL., vol. 46, July 2000 (2000-07-01), pages S52 - S61, XP002993665
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