Title:
USP30 INHIBITORS
Document Type and Number:
WIPO Patent Application WO/2018/213150
Kind Code:
A8
Abstract:
The application relates to phenyl- or naphthylsulfonamide derivatives of the structural formula (I). The compounds are described as inhibitors of USP30 (ubiquitin specific peptidase 30) useful for the treatment of conditions involving mitochondrial defects including neurodegenerative diseases such as Alzheimer's and Parkinson's or a neoplastic disease such as leukemia.
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Inventors:
KLUGE ARTHUR (US)
LAGU BHARAT (US)
MAITI PRANAB (IN)
PANIGRAHI SUNIL (IN)
LAGU BHARAT (US)
MAITI PRANAB (IN)
PANIGRAHI SUNIL (IN)
Application Number:
PCT/US2018/032486
Publication Date:
January 23, 2020
Filing Date:
May 14, 2018
Export Citation:
Assignee:
MITOBRIDGE INC (US)
International Classes:
C07D213/81; A61K31/18; A61K31/63; A61P9/00; A61P25/00; A61P25/16; A61P25/28; A61P35/00; C07C311/46; C07D207/16; C07D207/34; C07D213/56; C07D233/64; C07D237/24; C07D239/28; C07D263/34; C07D277/56; C07D307/24; C07D307/68; C07D309/04; C07D309/08; C07D333/24; C07D333/38; C07D409/12
Attorney, Agent or Firm:
DAVIS, Steven, G. et al. (US)
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