V TYPE AND/OR X TYPE sPLA2 INHIBITORS

Title:

V TYPE AND/OR X TYPE sPLA2 INHIBITORS

Document Type and Number:

WIPO Patent Application WO/2001/026653

Kind Code:

A1

Abstract:

V type and/or X type sPLA¿2? inhibitors which contain as the active ingredient compounds represented by general formulae (A), (B), (C), prodrugs thereof, pharmaceutically acceptable salts of the same or solvates of the same, wherein R?1¿, R?2¿, R?3¿ and R?4¿ independently represent each hydrogen, a non-interfering substituent, etc.; R?5¿ represents a carbon ring, a heterocycle, etc.; R?6¿ represents hydrogen, C¿1-3? alkyl, etc.; R?A¿ represents -COCONH¿2?, etc.; and R?B¿ represents -CONH¿2?, etc.

Inventors:

ONO TAKASHI (JP)
UENO MASAHIKO (JP)
HANASAKI KOHJI (JP)

Application Number:

PCT/JP2000/007024

Publication Date:

April 19, 2001

Filing Date:

October 10, 2000

Export Citation:

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Assignee:

SHIONOGI & CO (JP)
ONO TAKASHI (JP)
UENO MASAHIKO (JP)
HANASAKI KOHJI (JP)

International Classes:

A61K31/403; A61K31/404; A61K31/4045; A61K31/437; A61K31/4985; A61K31/5025; A61P29/00; A61P37/08; A61P43/00; C07D209/22; C07D209/88; C07D405/04; C07D471/04; C07D487/04; (IPC1-7): A61K31/403; A61K31/404; A61K31/437; A61K31/4985; A61K31/5025; A61P29/00; A61P37/08; A61P43/00; C07D209/12; C07D209/88; C07D405/04; C07D471/04; C07D487/04

Domestic Patent References:

WO1999025340A1	1999-05-27
WO1999051605A1	1999-10-14
WO1998037069A1	1998-08-27
WO1996003383A1	1996-02-08
WO1996003376A1	1996-02-08
WO1996003120A1	1996-02-08

Foreign References:

EP0675110A1	1995-10-04
EP0620214A1	1994-10-19
EP0620215A1	1994-10-19

Other References:

SAWADA H. ET AL.: "Regulation of type V phospholipase A2 expression and function by proinflammatory stimuli", EUR. J. BIOCHEM., vol. 263, 1999, pages 826 - 833, XP002934346

Attorney, Agent or Firm:

Yamauchi, Hideaki (Ltd. Intellectual Property Department 12-4 Sagisu 5-chom, Fukushima-ku Osaka-shi Osaka, JP)

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