Title:
VACCINE ADJUVANT AND MICRONEEDLE PREPARATION
Document Type and Number:
WIPO Patent Application WO/2019/021954
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a novel vaccine adjuvant. To solve this problem, provided is a vaccine adjuvant comprising dextran sulfate or a derivative thereof.
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Inventors:
TAKADA KANJI
Application Number:
PCT/JP2018/027247
Publication Date:
January 31, 2019
Filing Date:
July 20, 2018
Export Citation:
Assignee:
BIOSERENTACH CO LTD (JP)
International Classes:
A61K39/39; A61K9/00; A61K39/00; A61K47/36; A61M37/00
Domestic Patent References:
WO2014142135A1 | 2014-09-18 | |||
WO2009066763A1 | 2009-05-28 |
Foreign References:
US20110098651A1 | 2011-04-28 | |||
JP2007537783A | 2007-12-27 | |||
JP2009502261A | 2009-01-29 |
Other References:
HAN, H. R. ET AL.: "Effects of Adjuvants on the Immune Response of Staphylococcal Alpha Toxin and Capsular Pol ysaccharide (CPS) in Rabbit", J. VET. MED. SCI., vol. 62, no. 3, 2000, pages 237 - 241, XP055571856
WELDON, W. C. ET AL.: "Effect of Adjuvants on Responses to Skin Immunization by Microneedles Coated with Influenza Subunit Vaccine", PLOS ONE, vol. 7, no. 7, 25 July 2012 (2012-07-25), pages e41501, XP055056960
HILGERS, L. A. T. ET AL.: "Immunomodulating Properties of Two Synthetic Adjuvants: Dependence upon Type of Antigen, Dose, and Time of Administration", CELL . IMMUNOL., vol. 86, no. 2, July 1984 (1984-07-01), pages 393 - 401, XP024003558
WELDON, W. C. ET AL.: "Effect of Adjuvants on Responses to Skin Immunization by Microneedles Coated with Influenza Subunit Vaccine", PLOS ONE, vol. 7, no. 7, 25 July 2012 (2012-07-25), pages e41501, XP055056960
HILGERS, L. A. T. ET AL.: "Immunomodulating Properties of Two Synthetic Adjuvants: Dependence upon Type of Antigen, Dose, and Time of Administration", CELL . IMMUNOL., vol. 86, no. 2, July 1984 (1984-07-01), pages 393 - 401, XP024003558
Attorney, Agent or Firm:
YAMAO, Norihito et al. (JP)
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