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Title:
VACCINE AGAINST PATHOGENIC GRAM-NEGATIVE BACTERIA
Document Type and Number:
WIPO Patent Application WO/2018/147265
Kind Code:
A1
Abstract:
The present invention provides a vaccine against pathogenic gram-negative bacteria, the vaccine comprising a V antigen of a type III secretion system, a homolog protein thereof, a part thereof, or a gene encoding the V antigen, and a CpG oligodeoxynucleotide (CpG ODN) adjuvant.

Inventors:
SAWA, Teiji (465 Kajii-cho, Kawaramachi-dori Hirokoji-agaru, Kamigyo-ku, Kyoto-sh, Kyoto 66, 〒6028566, JP)
ISHII, Ken (Health and Nutrition 7-6-8, Saito-Asagi, Ibaraki-sh, Osaka 85, 〒5670085, JP)
HAMAOKA, Saeko (465 Kajii-cho, Kawaramachi-dori Hirokoji-agaru, Kamigyo-ku, Kyoto-sh, Kyoto 66, 〒6028566, JP)
NAITO, Yoshifumi (465 Kajii-cho, Kawaramachi-dori Hirokoji-agaru, Kamigyo-ku, Kyoto-sh, Kyoto 66, 〒6028566, JP)
Application Number:
JP2018/003991
Publication Date:
August 16, 2018
Filing Date:
February 06, 2018
Export Citation:
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Assignee:
KYOTO PREFECTURAL PUBLIC UNIVERSITY CORPORATION (465 Kajii-cho, Kawaramachi-dori Hirokoji-agaru Kamigyo-ku, Kyoto-sh, Kyoto 66, 〒6028566, JP)
NATIONAL INSTITUTES OF BIOMEDICAL INNOVATION, HEALTH AND NUTRITION (7-6-8, Saito-Asagi Ibaraki-sh, Osaka 85, 〒5670085, JP)
International Classes:
A61K39/104; A61K39/39; A61P31/04
Domestic Patent References:
WO2015041318A12015-03-26
Foreign References:
JP2015028066A2015-02-12
Other References:
SAWA T.: "???", JOURNAL OF KYOTO PREFECTURAL UNIVERSITY OF MEDICINE, vol. 120, no. 9, 25 September 2011 (2011-09-25), pages 659 - 671
SAWA, TEIJI ET AL.: "Active and passive immunization with the Pseudomonas V antigen protects against type III intoxication and lung injury", NATURE MEDICINE, vol. 5, no. 4, April 1999 (1999-04-01), pages 392 - 398, XP002142838, ISSN: 1546-170X
KRIEG A. M.: "Antiinfective Applications of Toll-like Receptor 9 Agonists", PROCEEDINGS OF THE AMMERICAN THORACIC SOCIETY, vol. 4, no. 3, July 2007 (2007-07-01), pages 289 - 294, XP055533121, ISSN: 2329-6933
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (Kitahama TNK Building, 1-7-1 Doshomachi, Chuo-ku, Osaka-sh, Osaka 45, 〒5410045, JP)
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