Title:
VACCINE COMPOSITION FOR PREVENTING AND TREATING MIDDLE EAST RESPIRATORY SYNDROME-CORONAVIRUS
Document Type and Number:
WIPO Patent Application WO/2022/030702
Kind Code:
A1
Abstract:
The present invention relates to a method for producing an antigen for preventing MERS-CoV infections and a vaccine composition produced by method, more specifically to a vaccine composition comprising a protein in which n-Coronavirus spike protein or S1 domain is bound with human fragment crystallization (Fc) domain, and to inducing immune responses and preventing viral infections by means of the vaccine composition.
Inventors:
JANG HYUN (KR)
JUNG BO-KYOUNG (KR)
AN YONG-HEE (KR)
JANG JIN-JU (KR)
KANG MIN-KYEONG (KR)
JUNG BO-KYOUNG (KR)
AN YONG-HEE (KR)
JANG JIN-JU (KR)
KANG MIN-KYEONG (KR)
Application Number:
PCT/KR2020/018033
Publication Date:
February 10, 2022
Filing Date:
December 10, 2020
Export Citation:
Assignee:
LIBENTECH CO LTD (KR)
International Classes:
C12N15/62; A61K39/00; A61K39/215; A61P31/14; C07K14/005; C12N15/85
Domestic Patent References:
| WO2016138160A1 | 2016-09-01 |
Foreign References:
| US20190328865A1 | 2019-10-31 |
Other References:
CHUN JUNGMIN, CHO YEONDONG, PARK KI HOON, CHOI HANUL, CHO HANSAM, LEE HEE-JUNG, JANG HYUN, KIM KYUNG HYUN, OH YU-KYOUNG, KIM YOUNG: "Effect of Fc Fusion on Folding and Immunogenicity of Middle East Respiratory Syndrome Coronavirus Spike Protein", JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, HAN'GUG MI'SAENGMUL SAENGMYEONG GONG HAGHOE,KOREAN SOCIETY FOR MICROBIOLOGY AND BIOTECHNOLOGY, KOREA, vol. 29, no. 5, 28 May 2019 (2019-05-28), Korea, pages 813 - 819, XP055895118, ISSN: 1017-7825, DOI: 10.4014/jmb.1903.03043
DATABASE NUCLEOTIDE 2 September 2015 (2015-09-02), ANONYMOUS: "Middle East respiratory syndrome coronavirus isolate MERS-CoV/KOR/KNIH/002_05_2015, complete genome", XP055811624, retrieved from NCBI Database accession no. KT029139
DATABASE NUCLEOTIDE 1 August 2016 (2016-08-01), ANONYMOUS : "Homo sapiens immunoglobulin gamma-2 heavy chain (IgH), immunoglobulin gamma-4 heavy chain (IgH), immunoglobulin epsilon chain constant region (IgH), and immunoglobulin alpha2 heavy chain (IgH) genes, partial cds", XP055895126, retrieved from NCBI Database accession no. AH005273
DATABASE NUCLEOTIDE 2 September 2015 (2015-09-02), ANONYMOUS: "Middle East respiratory syndrome coronavirus isolate MERS-CoV/KOR/KNIH/002_05_2015, complete genome", XP055811624, retrieved from NCBI Database accession no. KT029139
DATABASE NUCLEOTIDE 1 August 2016 (2016-08-01), ANONYMOUS : "Homo sapiens immunoglobulin gamma-2 heavy chain (IgH), immunoglobulin gamma-4 heavy chain (IgH), immunoglobulin epsilon chain constant region (IgH), and immunoglobulin alpha2 heavy chain (IgH) genes, partial cds", XP055895126, retrieved from NCBI Database accession no. AH005273
Attorney, Agent or Firm:
WIE, Byoung-Gap (KR)
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