Title:
VACCINE COMPOSITION FOR PREVENTING TUBERCULOSIS CONTAINING RV3112, MTBK 20620 OR MTBK 24820 PROTEIN
Document Type and Number:
WIPO Patent Application WO/2016/013873
Kind Code:
A1
Abstract:
The present invention relates to a vaccine composition for preventing tuberculosis containing Rv3112, MTBK 20620 or MTBK 24820 protein. When using Rv3112, MTBK 20620 or MTBK 24820 protein according to the present invention as an antigen, high IFN-γ producing ability is exhibited in the spleen and lung of an animal model in which infection by Mycobacterium tuberculosis has been induced, and tuberculosis can be effectively prevented by maintaining the formation of a quickly acquired protective immunity and memorization of T cell. Also, Rv3112, MTBK 20620 or MTBK 24820 protein according to the present invention can be used in the treatment of tuberculosis, and thus can be usefully used for preventing the relapse or reinfection of highly pathogenic tuberculosis having a high recurrence rate and for increasing the treatment efficiency thereof.
Inventors:
SHIN SUNG JAE (KR)
HAN SEUNG JUNG (KR)
CHA SEUNG BIN (KR)
KIM WOO SIK (KR)
KIM JONG SEOK (KR)
KIM HONG MIN (KR)
KWON KEE WOONG (KR)
CHO SANG NAE (KR)
HAN SEUNG JUNG (KR)
CHA SEUNG BIN (KR)
KIM WOO SIK (KR)
KIM JONG SEOK (KR)
KIM HONG MIN (KR)
KWON KEE WOONG (KR)
CHO SANG NAE (KR)
Application Number:
PCT/KR2015/007631
Publication Date:
January 28, 2016
Filing Date:
July 22, 2015
Export Citation:
Assignee:
UNIV YONSEI IACF (KR)
International Classes:
A61K38/16; A61K48/00; A61P31/06
Domestic Patent References:
| WO2012031752A2 | 2012-03-15 |
Other References:
RYOO, S. W. ET AL.: "Comparative Proteomic Analysis of Virulent Korean Mycobacterium tuberculosis K-strain with Other Mycobacteria Strain Following Infection of U-937 Macrophage", JOURNAL OF MICROBIOLOGY, vol. 45, 2007, pages 268 - 271
SHIN, A-R. ET AL.: "Improved Sensitivity of Diagnosis of Tuberculosis in Patients in Korea via a Cocktail Enzyme-Linked Immunosorbent Assay Containing the Abundantly Expressed Antigens of the K Strain of Mycobacterium tuberculosis", CLINICAL AND VACCINE IMMUNOLOGY, vol. 15, 2008, pages 1788 - 1795
DATABASE NCBI 29 August 2013 (2013-08-29), Database accession no. WP_003907828.1
DATABASE NCBI 29 August 2013 (2013-08-29), Database accession no. WP_003899918.1
DATABASE GenBank 5 June 2014 (2014-06-05), Database accession no. AIB49026.1
SHIN, A-R. ET AL.: "Improved Sensitivity of Diagnosis of Tuberculosis in Patients in Korea via a Cocktail Enzyme-Linked Immunosorbent Assay Containing the Abundantly Expressed Antigens of the K Strain of Mycobacterium tuberculosis", CLINICAL AND VACCINE IMMUNOLOGY, vol. 15, 2008, pages 1788 - 1795
DATABASE NCBI 29 August 2013 (2013-08-29), Database accession no. WP_003907828.1
DATABASE NCBI 29 August 2013 (2013-08-29), Database accession no. WP_003899918.1
DATABASE GenBank 5 June 2014 (2014-06-05), Database accession no. AIB49026.1
Attorney, Agent or Firm:
KIM, SOON WOONG (KR)
김순웅 (KR)
김순웅 (KR)
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