Title:
VACCINE COMPOSITIONS AND METHODS
Document Type and Number:
WIPO Patent Application WO2004058188
Kind Code:
A3
Abstract:
Methods of enhancing antigenic presentation or increasing immunogenicity of a polypeptide by modifying the three dimensional structure of a polypeptide.
Inventors:
SHNEIDER ALEXANDER M (US)
SHERMAN MICHAEL (US)
SHERMAN MICHAEL (US)
Application Number:
PCT/US2003/041350
Publication Date:
February 10, 2005
Filing Date:
December 22, 2003
Export Citation:
Assignee:
CURELAB INC (US)
SHNEIDER ALEXANDER M (US)
SHERMAN MICHAEL (US)
SHNEIDER ALEXANDER M (US)
SHERMAN MICHAEL (US)
International Classes:
A61K39/12; A61K39/145; A61K39/38; C07K5/103; C07K14/11; C07K17/00; C12N15/74; A61K38/00; A61K39/00; A61K; (IPC1-7): A61K39/145; A61K39/00; A61K39/12; C12N15/74; C07K17/00
Other References:
BERGMANN, C.C. ET AL: "Flanking residues alter antigenicity and immunogenicity of multi-unit CL epitopes", JOURNAL OF IMMUNOLOGY, vol. 157, no. 8, 1996, pages 3242 - 3249, XP002904287
YELLEN-SHAW. A.J. ET AL: "Point mutation flanking a CTL epitope ablates in vitro and in vivo recognition of a full-length viral protein", JOURNAL OF IMMUNOLOGY, vol. 158, no. 7, 1997, pages 3227 - 3234, XP002904288
YELLEN-SHAW. A.J. ET AL: "Point mutation flanking a CTL epitope ablates in vitro and in vivo recognition of a full-length viral protein", JOURNAL OF IMMUNOLOGY, vol. 158, no. 7, 1997, pages 3227 - 3234, XP002904288
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